Fully automatic smear preparation and film reading machine

By designing a fully automatic smear preparation and smear reading machine, integrating smear dyeing and smear reading functions, the problems of large space occupied by equipment and low detection efficiency in the existing technology are solved, and fast and efficient acquisition of detection results is achieved.

CN112284857BActive Publication Date: 2025-02-11URIT MEDICAL ELECTRONICS CO LTD
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Patent Information

Application Number
CN202011219629.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-11-03
Publication Date
2025-02-11
Estimated Expiration
2040-11-03

AI Technical Summary

Technical Problem

The lack of medical devices integrating the functions of pushing and reading tablets in the prior art leads to large space occupancy and low detection efficiency.

Method used

A fully automatic smear preparation and smear reading machine is designed, including a slide translation module, a slide push module, a staining module and a microscope module. Automatic slide pushing, staining and microscopic examination of the slides are realized through a robot.

Benefits of technology

The integration of the functions of pushing and reading films is realized, reducing the equipment space occupied, improving detection efficiency, quickly obtaining test results, and reducing the waiting time for doctors and patients.

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Abstract

The present invention discloses a fully automatic smear preparation and film reading integrated machine, comprising a machine body frame, and a slide translation module, a slide pushing module, a staining module and a microscope module arranged on the machine body frame. Through the cooperation between the above modules, the functions of the two instruments can be integrated, not only integrating the functions of slide pushing, staining and film reading into one, but also one instrument occupies less space in the hospital than two instruments, and the sample conveying mechanism required by the two instruments is omitted in the middle of the instrument. The stained blood smear can be directly examined under a microscope in one instrument, and the test results can be obtained more quickly, reducing the time for doctors and patients to wait for the results, which has a positive effect on the detection of diseases.
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Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a fully automatic smear preparation and film reading integrated machine. Background Art

[0002] The current existing medical products are two instruments for slide staining and slide reading. The slide staining machine is used for smear preparation and staining, and the slide reading machine is used for microscopic examination of smears. However, there is currently no instrument on the market that integrates the functions of slide staining and slide reading. Therefore, it is very necessary to provide a fully automatic smear preparation and slide reading machine. Summary of the invention

[0003] The purpose of the present invention is to provide a fully automatic smear preparation and film reading machine, aiming to solve the technical problem in the prior art that there is no instrument integrating the functions of film pushing, staining and film reading on the market.

[0004] To achieve the above-mentioned purpose, the present invention adopts a fully automatic smear preparation and film reading integrated machine, comprising a machine body frame, and a glass slide translation module, a slide pushing module, a staining module and a microscope module arranged on the machine body frame, the glass slide translation module comprising a glass slide box sample feeding component for driving glass slides to be fed in, a glass slide box sample discharging component for driving glass slides to be discharged, a glass slide clamping manipulator component and a glass slide box translation support, the glass slide box translation support is arranged between the glass slide box sample feeding component and the glass slide box sample discharging component, the glass slide clamping manipulator component is arranged above the glass slide box translation support, and the lever is arranged on one side of the glass slide box translation support;

[0005] The slide pushing module comprises a sample dropping component, a push knife component, a slide transfer component, a slide information reading and writing component and a slide pushing base, wherein the sample dropping component is arranged on the slide pushing base, the slide pushing base is arranged on the body frame, and the push knife component, the slide transfer component and the slide information reading and writing component are all arranged on one side of the sample dropping component;

[0006] The dyeing module comprises a dyeing pool component and a first air-drying component, wherein the dyeing pool component is arranged on the body frame, and the first air-drying component is located on one side of the dyeing pool component;

[0007] The microscope module includes a microscope barrel, an illumination component, a CCD camera component, a glass slide flipping component, a glass slide shifting component and an XY platform component. The illumination component is arranged below the microscope barrel, the CCD camera component is arranged above the microscope barrel, the XY platform component is placed below the microscope barrel, the glass slide flipping component is arranged above the side of the XY platform component, and the glass slide shifting component is arranged above the glass slide flipping component.

[0008] Wherein, the glass slide clamping robot component includes a first base, an X-direction motor, a Y-direction motor, a Z-direction motor, an X-direction guide, a Y-direction guide, a Z-direction guide, a mechanical claw, a mechanical claw fixing plate, a Y-direction motor guide fixing plate, and a Z-direction motor guide fixing plate. The X-direction motor and the X-direction guide are respectively fixedly connected to the first base, the Y-direction motor and the Y-direction guide are respectively fixedly connected to the Y-direction motor guide fixing plate, the Z-direction motor and the Z-direction guide are respectively fixedly connected to the Z-direction motor guide fixing plate, the mechanical claw is fixedly connected to the mechanical claw fixing plate, the mechanical claw fixing plate is slidably connected to the Y-direction motor guide fixing plate, the Y-direction motor guide fixing plate is slidably connected to the Z-direction motor guide fixing plate, and the Z-direction motor guide fixing plate is slidably connected to the first base.

[0009] Among them, the sample dropping component is composed of a sample dropping tube, a first cleaning sleeve and a sample dropping motor, the push knife component is composed of a push knife longitudinal motor, a push knife transverse motor, a push knife base and a push knife moving block, and the glass slide transfer component is composed of a glass slide flipping assembly and a push knife cleaning component.

[0010] Wherein, the slide pushing module further comprises a flip guide plate and a second air-drying component, wherein the flip guide plate is arranged on one side of the slide transferring component, and the second air-drying component is arranged on one side of the sample dropping component.

[0011] Wherein, the dyeing pool component is composed of a dyeing pool, a dyeing pool fixing seat, a dyeing pool needle tube fixing seat, a long needle tube, a short needle tube, a plastic tube and a cable fixing seat.

[0012] The microscope barrel comprises a barrel body, an eyepiece and an objective lens, wherein the eyepiece and the objective lens are arranged in sequence from top to bottom along the axial line direction of the barrel body, and the lighting component consists of an LED light source board, an aperture and a lighting base.

[0013] Among them, the glass slide flipping component includes a flipping transverse motor, a flipping component base, a first synchronous belt, a synchronous belt pressure plate, a first synchronous wheel, a guide rail, a flipping bearing base and a glass slide flipping seat, the guide rail and the flipping transverse motor are respectively fixedly connected to the flipping component base, the flipping bearing base is fixedly connected to the guide rail, the flipping bearing base is rotatably connected to the glass slide flipping seat, the synchronous belt pressure plate is fixedly connected to the flipping bearing base, the first synchronous belt is fixedly connected to the flipping bearing base via the synchronous belt pressure plate, and the first synchronous belt is rotatably connected to the flipping transverse motor via the first synchronous wheel.

[0014] The beneficial effects of the present invention are as follows: a clean glass slide is placed in a glass slide box, and is sent from the glass slide box sample introduction component to the entrance of the glass slide box translation support, and is dialed into the working position inside the instrument by the lever, the glass slide clamping manipulator component first clamps a glass slide to the working position of the glass slide information reading and writing module in the slide pushing module, and reads the glass slide information, including bar code information and radio frequency card information, and then the glass slide clamping manipulator component sends the glass slide to the working position of the glass slide transfer component of the slide pushing module, and the glass slide transfer component sends the glass slide to the working position of the sample dropping component in turn, and the working position of the push knife component After the slide pushing action is completed, the slide clamping manipulator component sends the slide to the working position of the staining pool component in the staining module. After the slide staining action is completed, the slide clamping manipulator component sends the slide to the working position of the slide flipping component of the microscope module. The slide flipping component sends the pushed and stained slide to the working position of the XY platform component to perform a microscope examination of the slide. After that, the slide clamping manipulator component sends the slide back to the slide box located on the slide box translation support. Finally, the lever sends the slide box to the slide box sample output component. The above structure sets the functions of the two instruments into one, which not only integrates the functions of slide pushing, staining and reading, but also occupies less space in the hospital than two instruments. The sample transmission mechanism required by the two instruments is missing in the middle of the instrument. The stained blood smear can be directly examined by a microscope in one instrument, and the test results can be obtained more quickly, reducing the time for doctors and patients to wait for the results, which has a positive effect on the detection of diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0016] Figure 1 It is the overall assembly diagram of the fully automatic smear preparation and film reading integrated machine of the present invention.

[0017] Figure 2 It is a schematic diagram of the structure of the puncture and mixing module of the present invention.

[0018] Figure 3 It is a structural schematic diagram of the slide translation module of the present invention.

[0019] Figure 4 It is a structural schematic diagram of the film pushing module of the present invention.

[0020] Figure 5 It is a structural schematic diagram of the dyeing module of the present invention.

[0021] Figure 6 It is a structural schematic diagram of the microscope module of the present invention.

[0022] Figure 7 It is a schematic diagram of the structure of the glass slide clamping robot components of the present invention.

[0023] 1-microscope module, 2-staining module, 3-control circuit component, 4-slide translation module, 5-slide box, 6-body frame, 7-slide push module, 8-puncture mixing module, 101-microscope tube, 102-illumination component, 103-XY platform component, 104-slide flip component, 105-slide toggle component, 106-CCD camera component, 1041-flip horizontal motor, 1042-flip component base, 1043-first synchronous belt, 1044-synchronous belt pressure plate, 1045-first synchronous wheel, 1046-guide rail, 1047-flip bearing base, 1048-slide flip seat, 1049-flip guide block, 201-staining pool component, 202-first air drying component, 201 1-staining pool fixing seat, 2012-staining pool, 2013-staining pool needle tube fixing seat, 2014-short needle tube, 2015-long needle tube, 2016-cable fixing seat, 401-slide box sample inlet component, 4001-slide box sample outlet component, 402-slide clamping manipulator component, 403-slide box translation component, 404-push rod, 405-slide box translation bracket, 4011-inlet and outlet rotating motor, 4012-coupling, 4013-driving wheel, 4014-large driven wheel, 4015-small driven wheel, 4016-synchronous belt, 4023-first base, 4021-X direction motor, 4026-Y direction motor, 4024-Z direction motor, 4022-X direction guide rail, 4027 -Y-direction guide rail, 4028-Z-direction guide rail, 40211-mechanical claw, 40210-mechanical claw fixing plate, 4025-Y-direction motor guide rail fixing plate, 4029-Z-direction motor guide rail fixing plate, 701-second air-drying component, 702-sample dripping component, 703-push knife component, 704-slide information reading and writing component, 705-slide transfer component, 706-flip guide plate, 707-push slide base, 70512-slide flip assembly, 70513-push knife cleaning component, 7021-sample dripping tube, 7022-first cleaning set, 7023-sample dripping motor, 7031-push knife moving block, 7032-longitudinal motor drag plate, 7033-push knife longitudinal motor, 7034-push knife transverse motor, 7035-push knife base, 7036-bearing, 7037-push knife, 7051-slide transfer motor, 7052-slide transfer synchronous belt, 7053-slide transfer guide rail, 7054-push knife drying cotton mounting plate, 7055-push knife cleaning component base, 7056-push knife cleaning tank, 7057-bolt type bearing, 7058-slide flip base, 7059-slide flip shaft, 70510-slide flip tank, 70511-slide transfer synchronous wheel assembly, 801-sampling component, 802-manipulator mixing component, 803-second base, 804-barcode reader drive component, 8011-sampling needle, 8014-sampling arm, 8012-second cleaning cover, 8013-cleaning cover fixing bracket,80110-first motor, 8019-second motor, 8015-first slide rail, 8017-guide rod, 8016-sampling support plate, 8018-sampling longitudinal base, 8021-third motor, 8022-fourth motor, 8027-fifth motor, 8028-vertical support plate, 8029-second slide rail, 8025-upper and lower sliders, 8026-mixing motor fixing parts, 8023-test tube, 8024-test tube clamp fixing block, 8043-scanner fixing plate, 8049 -The third slide rail, 8044-barcode reader, 8045-slide rail mounting plate, 8047-sixth motor, 8048-two-head screw, 80410-nut fixing block, 8042-mixing head bracket, 8041-barcode reader synchronous wheel rotating head assembly, 8046-second synchronous wheel, 80210-vertical motor bracket, 80211-horizontal motor fixing plate, 80212-longitudinal guide rod, 80213-mixing slider, 80214-test tube clamp, 80411-second synchronous belt. , DETAILED DESCRIPTION

[0024] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0025] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, in the description of the present invention, "multiple" means two or more, unless otherwise clearly and specifically defined.

[0026] See also Figures 1 to 7The present invention provides a fully automatic smear preparation and film reading integrated machine, comprising a machine frame 6, and a glass slide translation module 4, a slide pushing module 7, a staining module 2 and a microscope module 1 arranged on the machine frame 6, the glass slide translation module 4 comprising a glass slide box sample introduction component 401 for driving glass slides to be introduced, a glass slide box sample discharging component 4001 for driving glass slides to be discharged, a glass slide clamping manipulator component 402, a glass slide box translation support 405 and a lever 404, the glass slide box translation support 405 is arranged between the glass slide box sample introduction component 401 and the glass slide box sample discharging component 4001, the glass slide clamping manipulator component 402 is arranged above the glass slide box translation support 405, and the lever 404 is arranged on one side of the glass slide box translation support 405;

[0027] The slide pushing module 7 includes a sample dropping component 702, a knife pushing component 703, a slide transfer component 705, a slide information reading and writing component 704 and a slide pushing base 707. The sample dropping component 702 is arranged on the slide pushing base 707, and the slide pushing base 707 is arranged on the body frame 6. The knife pushing component 703, the slide transfer component 705 and the slide information reading and writing component 704 are all arranged on one side of the sample dropping component 702.

[0028] The dyeing module 2 includes a dyeing pool component 201 and a first air-drying component 202, wherein the dyeing pool component 201 is disposed on the body frame 6, and the first air-drying component 202 is located on one side of the dyeing pool component 201;

[0029] The microscope module 1 includes a microscope barrel 101, an illumination component 102, a CCD camera component 106, a glass slide flipping component 104, a glass slide shifting component 105 and an XY platform component 103. The illumination component 102 is arranged below the microscope barrel 101, the CCD camera component 106 is arranged above the microscope barrel 101, the XY platform component 103 is placed below the microscope barrel 101, the glass slide flipping component 104 is arranged on the upper side of the XY platform component 103, and the glass slide shifting component 105 is arranged above the glass slide flipping component 104.

[0030] The slide clamping robot component 402 includes a first base 4023, an X-direction motor 4021, a Y-direction motor 4026, a Z-direction motor 4024, an X-direction guide rail 4022, a Y-direction guide rail 4027, a Z-direction guide rail 4028, a mechanical claw 40211, a mechanical claw fixing plate 40210, a Y-direction motor guide rail fixing plate 4025, and a Z-direction motor guide rail fixing plate 4029. The X-direction motor 4021 and the X-direction guide rail 4022 are fixedly connected to the first base 4023 respectively, and the Y-direction motor 4026 and the Y-direction guide rail 4027 are respectively It is fixedly connected to the Y-direction motor guide rail fixing plate 4025, the Z-direction motor 4024 and the Z-direction guide 4028 are respectively fixedly connected to the Z-direction motor guide rail fixing plate 4029, the mechanical claw 40211 is fixedly connected to the mechanical claw fixing plate 40210, the mechanical claw fixing plate 40210 is slidably connected to the Y-direction motor guide rail fixing plate 4025, the Y-direction motor guide rail fixing plate 4025 is slidably connected to the Z-direction motor guide rail fixing plate 4029, and the Z-direction motor guide rail fixing plate 4029 is slidably connected to the first base 4023.

[0031] The sample dropping component 702 is composed of a sample dropping tube 7021, a first cleaning sleeve 7022 and a sample dropping motor 7023. The push knife component 703 is composed of a push knife longitudinal motor 7033, a push knife transverse motor 7034, a push knife base 7035 and a push knife moving block 7031. The glass slide transfer component 705 is composed of a glass slide turning assembly 70512 and a push knife cleaning component 70513.

[0032] The slide pushing module 7 further includes a flip guide plate 706 and a second air-drying component 701 . The flip guide plate 706 is disposed on one side of the slide transferring component 705 , and the second air-drying component 701 is disposed on one side of the sample dropping component 702 .

[0033] The dyeing pool component 201 is composed of a dyeing pool 2012, a dyeing pool fixing seat 2011, a dyeing pool needle tube fixing seat 2013, a long needle tube 2015, a short needle tube 2014, a plastic tube and a cable fixing seat 2016.

[0034] The microscope barrel 101 includes a barrel body, an eyepiece and an objective lens, and the eyepiece and the objective lens are arranged in sequence from top to bottom along the axial line direction of the barrel body. The lighting component 102 is composed of an LED light source board, an aperture and a lighting base.

[0035] The glass slide flipping component 104 includes a flipping transverse motor 1041, a flipping component base 1042, a first synchronous belt 1043, a synchronous belt pressure plate 1044, a first synchronous wheel 1045, a guide rail 1046, a flip bearing base 1047 and a glass slide flipping seat 1048. The guide rail 1046 and the flipping transverse motor 1041 are respectively fixedly connected to the flipping component base 1042, the flip bearing base 1047 is fixedly connected to the guide rail 1046, the flip bearing base 1047 is rotatably connected to the glass slide flipping seat 1048, the synchronous belt pressure plate 1044 is fixedly connected to the flip bearing base 1047, the first synchronous belt 1043 is fixedly connected to the flip bearing base 1047 through the synchronous belt pressure plate 1044, and the first synchronous belt 1043 is rotatably connected to the flipping transverse motor 1041 through the first synchronous wheel 1045.

[0036] The fully automatic smear preparation and film reading machine also includes a puncture mixing module 8, which includes the sampling component 801, a manipulator mixing component 802, a second base 803 and a barcode reader driving component 804. The sampling component 801 includes a sampling needle 8011, a sampling arm 8014, a second cleaning sleeve 8012, a cleaning sleeve fixing frame 8013, a first motor 80110, a second motor 8019, a guide rod 8017, a sampling support plate 8016 and a sampling longitudinal base 8018. The sampling needle 8011 and the sampling arm 8014 are fixedly connected. The guide rod 8017 and the first motor 80110 are respectively fixedly connected to the sampling support plate 8016, the second cleaning cover 8012 and the cleaning cover fixing frame 8013 are respectively fixedly connected to the sampling support plate 8016, the second motor 8019 is fixedly connected to the sampling longitudinal base 8018, the sampling longitudinal base 8018 is provided with a first slide rail 8015, the sampling longitudinal base 8018 is slidably connected to the sampling support plate 8016 through the guide rod 8017, and the sampling arm 8014 is slidably connected to the sampling longitudinal base 8018.

[0037] The manipulator mixing component 802 includes a third motor 8021, a fourth motor 8022, a fifth motor 8027, a vertical support plate 8028, a vertical motor bracket 80210, a horizontal motor fixing plate 80211, a second slide rail 8029, a longitudinal guide rod 80212, an upper and lower sliders 8025, a mixing slider 80213, a mixing motor fixing piece 8026, a test tube clamp 80214 and a test tube clamp fixing block 8024, the vertical support plate 8028 is fixedly connected to the horizontal motor fixing plate 80211, the third motor 8021 and the second slide rail 8029 are respectively fixedly connected to the horizontal motor fixing plate 80211, and the mixing The slider 80213 is slidably connected to the horizontal motor fixing plate 80211, and the mixing slider 80213 is fixedly connected to the vertical motor bracket 80210, the fourth motor 8022 and the longitudinal guide rod 80212 are respectively fixedly connected to the vertical motor bracket 80210, the upper and lower sliders 8025 are slidably connected to the vertical motor bracket 80210, the upper and lower sliders 8025 and the fifth motor 8027 are respectively fixedly connected to the mixing motor fixing piece 8026, the fifth motor 8027 is rotatably connected to the test tube clamp fixing block 8024, and the test tube clamp 80214 is fixedly connected to the test tube clamp fixing block 8024.

[0038] The barcode reader driving component 804 includes a scanner fixing plate 8043, a third slide rail 8049, a barcode reader 8044, a slide rail mounting plate 8045, a sixth motor 8047, a two-head screw 8048, a nut fixing block 80410, a mixing head bracket 8042, a barcode reader synchronous wheel rotating head assembly 8041, a second synchronous wheel 8046 and a second synchronous belt 80411. The third slide rail 8049 and the barcode reader 8044 are fixedly connected to the scanner fixing plate 8043 respectively, and the slide rail mounting plate 8045 They are respectively fixedly connected to the third slide rail 8049, the mixing head bracket 8042 and the sixth motor 8047, the barcode reader synchronous wheel rotating head assembly 8041 is meshed with the second synchronous wheel 8046 through the second synchronous belt 80411, the sixth motor 8047 is fixedly connected to the two-head screw 8048 through the coupling 4012, the nut fixing block 80410 is fixedly connected to the nut of the two-head screw 8048, and the nut fixing block 80410 is fixedly connected to the scanner fixing plate 8043.

[0039] In this embodiment, a clean glass slide is placed in the glass slide box 5, and is sent from the glass slide box sample introduction component 401 to the entrance of the glass slide box translation bracket 405, and is dialed into the working position inside the instrument by the lever 404. The glass slide clamping robot component 402 first clamps a glass slide to the working position of the glass slide information reading and writing module in the slide pushing module 7 to read the glass slide information, including bar code information and radio frequency card information. Then, the glass slide clamping robot component 402 sends the glass slide to the working position of the glass slide transfer component 705 of the slide pushing module 7, and the glass slide transfer component 705 successively sends the glass slide to the working position of the sample dropping component 702 and the working position of the knife pushing component 703, completing the process. After the slide is pushed, the slide clamping robot component 402 sends the slide to the working position of the staining pool component 201 in the staining module 2. After the staining of the slide is completed, the slide clamping robot component 402 sends the slide to the working position of the slide flipping component 104 of the microscope module 1. The slide flipping component 104 sends the pushed and stained slide to the working position of the XY platform component 103 for microscope examination. After that, the slide clamping robot component 402 sends the slide back to the slide box 5 located on the slide box translation bracket 405. Finally, the lever 404 sends the slide box 5 to the slide box sample output component 4001. Through the above-mentioned structural setting, the functions of the two instruments are integrated into one, which not only integrates the functions of film pushing, staining and film reading, but also one instrument occupies less space in the hospital than two instruments. The sample transfer mechanism required by the two instruments is omitted in the middle of the instrument. The stained blood smear can be directly examined under a microscope in one instrument, and the test results can be obtained more quickly, reducing the waiting time for doctors and patients for the results, which has a positive effect on disease detection.

[0040] The dyeing pool component 201 is composed of a dyeing pool 2012, a dyeing pool fixing seat 2011, a dyeing pool needle tube fixing seat 2013, a long needle tube 2015, a short needle tube 2014, a plastic tube and a cable fixing seat 2016; the dyeing pool fixing seat 2011 is fixed to the body frame 6, and the dyeing pool needle tube fixing seat 2013 is fixedly connected to the dyeing pool fixing seat 2011 by bolts, and the dyeing pool needle tube fixing seat 2013 and the internal groove of the dyeing pool fixing seat 2011 jointly form a limiting groove for limiting the dyeing pool 2012, and the dyeing pool 2012 can be quickly disassembled by removing the bolts; the long needle tube 2015 and the short needle tube 2014 are respectively connected to the dyeing pool needle tube fixing seat 2011. The fixed seat 2013 is fixedly connected, and the number of the dyeing pools 2012 is multiple, and the multiple dyeing pools 2012 are arranged in parallel in the limiting groove formed by the dyeing pool fixing seat 2011 and the dyeing pool needle tube fixing seat 2013. The number of the long needle tubes 2015 and the short needle tubes 2014 is multiple, and each of the long needle tubes 2015 and the short needle tubes 2014 is respectively adapted to a dyeing pool 2012, and the short needle tubes 2014 transport the dye solution and the cleaning solution to the inner cavity of the dyeing pool 2012, and the long needle tubes 2015 drain the used dye solution and the cleaning solution; the dyeing pool 2012 is used to place glass slides and dye solution, and the dyeing pool 2012 can be quickly disassembled for easy cleaning.

[0041] The slide holding robot component 402 includes a first base 4023, an X-direction motor 4021, a Y-direction motor 4026, a Z-direction motor 4024, an X-direction guide rail 4022, a Y-direction guide rail 4027, a Z-direction guide rail 4028, a mechanical claw 40211, a mechanical claw fixing plate 40210, a Y-direction motor guide rail fixing plate 4025, and a Z-direction motor guide rail fixing plate 4029. The X-direction motor 4021 and the X-direction guide rail 4022 are separated. The Y-direction motor 4026 and the Y-direction guide rail 4027 are respectively fixedly connected to the Y-direction motor guide rail fixing plate 4025, the Z-direction motor 4024 and the Z-direction guide rail 4028 are respectively fixedly connected to the Z-direction motor guide rail fixing plate 4029, the mechanical claw 40211 is fixedly connected to the mechanical claw fixing plate 40210, and the mechanical claw fixing plate 40210 is connected to the Y-direction guide rail 4027. The Y-direction motor guide rail fixing plate 4025 is slidably connected, the Y-direction motor guide rail fixing plate 4025 is slidably connected through the Z-direction guide rail 4028 and the Z-direction motor guide rail fixing plate 4029, and the Z-direction motor guide rail fixing plate 4029 is slidably connected to the base 4023 through the X-direction guide rail 4022; the Y-direction motor 4026 rotates to drive the mechanical claw 40211 to move forward and backward in the Y direction; the Z-direction motor 4024 rotates to drive the Y-direction motor guide rail fixing plate 4025 to move up and down in the Z direction, and at the same time drives the mechanical claw 40211 to move up and down in the Z direction; the X-direction motor 4021 rotates to drive the Z-direction motor guide rail fixing plate 4029 to move left and right in the X direction, and at the same time drives the mechanical claw 40211 to move left and right in the X direction; the glass slide clamping robot component 402 realizes movement in three directions of X, Y, and Z, so that it has the function of transporting glass slides to each of the working positions.

[0042] The fully automatic smear preparation and film reading machine further comprises a control circuit component, and the control circuit component is electrically connected to the slide translation module 4, the slide pushing module 7, the staining module 2 and the microscope module 1 respectively.

[0043] The puncture mixing module 8 is mainly composed of the sampling component 801, the manipulator mixing component 802, and the barcode reader driving component 804. The sampling component 801 is used to take samples and clean the sampling needle 8011, the manipulator mixing component 802 is used to mix the test tube 8023 containing the sample, and the barcode reader driving component 804 is used to read the barcode attached to the test tube 8023.

[0044] Among them, the fully automatic smear preparation and film reading machine also includes a puncture mixing module 8, which includes the sampling component 801, the manipulator mixing component 802, the barcode reader driving component 804 and the second base 803, and these components are fixed on the second base 803 to form a module; the sampling component 801 includes a sampling needle 8011, a sampling arm 8014, a second cleaning cover 8012, a cleaning cover fixing frame 8013, a first motor 80110, a second motor 8019, a guide rod 8017, a sampling support plate 8016 and a sampling longitudinal base 8018; the sampling needle 8011 and the sampling arm 8014 are fixedly connected, the guide rod 8017 and the first motor 80110 are fixedly connected to the sampling support plate 8016 respectively, the second cleaning cover 8012 and the cleaning cover fixing frame 8013 are fixedly connected, and the The cleaning sleeve fixing frame 8013 is fixedly connected to the sampling support plate 8016, the second motor 8019 is fixedly connected to the sampling longitudinal base 8018, a first slide rail 8015 is arranged on the sampling longitudinal base 8018, the sampling arm 8014 is slidably connected to the slider of the first slide rail 8015, the second motor 8019 rotates to drive the sampling arm 8014 to move up and down, the sampling arm 8014 moves up and down to drive the sampling needle 8011 to move up and down, when moving downward, the puncture sampling function is realized, and when moving upward, the sampling needle 8011 is retracted in the second cleaning sleeve 8012 to clean the sampling needle 8011; the sampling longitudinal base 8018 is slidably connected to the sampling support plate 8016 through the guide rod 8017, the first motor 80110 rotates to drive the sampling needle 8011 to move back and forth, and change the sampling position.

[0045] When the mechanism moves downward, the sampling needle 8011 performs a puncture sampling action, and moves upward to cause the sampling needle 8011 to retract into the second cleaning sleeve 8012 to clean the sampling needle 8011; the manipulator mixing component 802 includes a third motor 8021, a fourth motor 8022, a fifth motor 8027, a vertical support plate 8028, a vertical motor bracket 80210, a horizontal motor fixing plate 80211, a second slide rail 8029, a longitudinal guide rod 80212, an upper and lower slider 8025, a mixing slider 80213, a mixing motor fixing part 8026, a test tube clamp 80214 and a test tube clamp fixing block 8024.

[0046] The fifth motor 8027 is rotatably connected to the test tube clamp fixing block 8024, and the test tube clamp 80214 is fixedly connected to the test tube clamp fixing block 8024. The rotation of the fifth motor 8027 drives the test tube clamp 80214 and the test tube clamp fixing block 8024 to rotate. The test tube clamp 80214 holds a test tube 8023. When the test tube clamp 80214 is rotated, the test tube 8023 will also rotate, thereby mixing the blood sample in the test tube 8023; the third motor 8021 is fixedly connected to the vertical motor bracket 80210, the upper and lower sliders 8025 and the fifth motor 8027 are respectively fixedly connected to the mixing motor fixing piece 8026, the third motor 8021 is slidably connected to the upper and lower sliders 8025, and the rotation of the third motor 8021 drives the upper and lower sliders 8025 to slide, thereby driving the The test tube clamp 80214 moves up and down, simulating the action of manually taking the test tube 8023 from the test tube rack 8023. The longitudinal guide rod 80212 is fixedly connected to the vertical motor bracket 80210 and is slidably connected to the upper and lower sliders 8025, so as to make the upper and lower sliders 8025 slide smoothly; the vertical motor bracket 80210 is fixedly connected to the slider of the second slide rail 8029, the slide rail of the second slide rail 8029 is fixedly connected to the vertical support plate 8028, the vertical motor bracket 80210 is slidably connected to the vertical support plate 8028, the fourth motor 8022 is fixedly connected to the vertical support plate 8028, and the fourth motor 8022 rotates to drive the vertical motor bracket 80210 to move forward and backward, thereby driving the test tube clamp 80214 to move forward and backward, simulating the action of manually clamping the test tube 8023. The third motor 8021 and the fourth motor 8022 rotate to drive the test tube clamp 80214 to move forward and backward and up and down, so that the test tube clamp 80214 clamps the test tube 8023; the fifth motor 8027 rotates to drive the test tube clamp 80214 to rotate, so that the test tube clamp 80214 drives the test tube 8023 to rotate and mix;

[0047] The barcode reader driving component 804 includes a scanner fixing plate 8043, a third slide rail 8049, a barcode reader 8044, a slide rail mounting plate 8045, a sixth motor 8047, a two-head screw 8048, a nut fixing block 80410, a mixing head bracket 8042, a barcode reader synchronous wheel rotating head assembly 8041, a second synchronous wheel 8046 and a second synchronous belt 80411. The third slide rail 8049 and the barcode reader 8044 are fixedly connected to the scanner fixing plate 8043 respectively, and the slide rail mounting plate 8045 is fixedly connected to the third The slide rail 8049, the mixing head bracket 8042 and the sixth motor 8047 are fixedly connected, the barcode reader synchronous wheel rotating head assembly 8041 cooperates with the second synchronous wheel 8046, and the second synchronous wheel 8046 is meshed with the second synchronous belt 80411, the sixth motor 8047 is fixedly connected with the two-head screw 8048 through the coupling 4012, the nut fixing block 80410 is fixedly connected with the nut of the two-head screw 8048, and the nut fixing block 80410 is fixedly connected with the scanner fixing plate 8043. The rotation of the sixth motor 8047 drives the two-head screw 8048 to rotate, and drives the barcode reader synchronous wheel rotating head assembly 8041 to rotate through the synchronous belt 4016, thereby driving the test tube 8023 to rotate, and the barcode reader 8044 reads the barcode sticker attached to the wall of the test tube 8023, and reads the information of the test tube 8023.

[0048] The barcode reader driving component 804 includes a scanner fixing plate 8043, a third slide rail 8049, a barcode reader 8044, a slide rail mounting plate 8045, a sixth motor 8047, a two-head screw 8048, a nut fixing block 80410, a mixing head bracket 8042, a barcode reader synchronous wheel rotating head assembly 8041, a second synchronous wheel 8046 and a second synchronous belt 80411; the third slide rail 8049 and the barcode reader 8044 are respectively fixedly connected to the scanner fixing plate 8043, the slide rail mounting plate 8045 is respectively fixedly connected to the third slide rail 8049, the mixing head bracket 8042 and the sixth motor 8047, the barcode reader synchronous wheel rotating head assembly 8041 cooperates with the second synchronous wheel 8046, and the second synchronous wheel 8046 is meshed with the second synchronous belt 80411. The sixth motor 8047 is fixedly connected to the two-head screw 8048 through the coupling 4012, the nut fixing block 80410 is fixedly connected to the nut of the two-head screw 8048, and the nut fixing block 80410 is fixedly connected to the scanner fixing plate 8043. The sixth motor 8047 rotates to drive the mixing head bracket 8042 and the barcode reader synchronous wheel rotating head assembly 8041 to move up and down, driving the second synchronous wheel 8046 to rotate, and the second synchronous wheel 8046 drives the barcode reader synchronous wheel rotating head assembly 8041 to rotate. When the barcode reader synchronous wheel rotating head assembly 8041 moves downward, it will rotate, and will contact the test tube 8023 when it moves downward for a certain distance, and drive the test tube 8023 to rotate, so that the barcode reader 8044 scans the barcode attached to the wall of the test tube 8023.

[0049] The slide box sample inlet component 401 and the slide box sample outlet component 4001 are both used to transport the slide box 5, and the slide box 5 is used to load slides.

[0050] The slide box sample inlet component 401 and the slide box sample outlet component 4001 both include a sample inlet and outlet rotating motor 4011, a coupling 4012, a driving wheel 4013, a large driven wheel 4014, a small driven wheel 4015 and a synchronous belt 4016; the driving wheel 4013 is fixedly connected to the sample inlet and outlet rotating motor 4011 through the coupling 4012, and the sample inlet and outlet rotating motor 4011 rotates to drive the driving wheel 4013 to rotate, and the synchronous belt 4016 is slidingly connected to the large driven wheel 4014 and the small driven wheel 4015, and there are S2M-shaped teeth on the inner side of the synchronous belt 4016 and the outer side of the driving wheel 4013, and the synchronous belt 4016 is meshed with the driving wheel 4013, and the rotation of the driving wheel 4013 drives the synchronous belt 4016 to rotate, and the slide box 5 is placed on the synchronous belt 4016 and moves back and forth driven by the synchronous belt 4016. The slide clamping robot component 402 is used to transfer a single slide between the slide information reading and writing workstation, the staining workstation and the flipping workstation. The controller controls the motor to move the mechanical claw 40211 in the X, Y and Z directions; the slide box translation bracket 405 is located inside the instrument and is used to place the slide box 5 channel during work.

[0051] The sample dropping component 702 is used to drop the sample to be tested onto a clean glass slide, and the first cleaning sleeve 7022 is used to clean the sample dropping tube 7021; the push knife component 703 is used to control the height and angle of the push knife 7037, including a push knife longitudinal motor 7033, a push knife transverse motor 7034, a push knife base 7035, and a push knife moving block 7031; the glass slide transfer component 705 is composed of a glass slide flipping component 70512 and a push knife cleaning component 70513, the glass slide flipping component 70512 and the flipping guide plate 706 are used to change the glass slide into a vertical state or a horizontal state, the push knife cleaning component 70513 is used to clean the push knife 7037 on the push knife component 703, the push knife cleaning component 70513 simplifies the liquid circuit module, and the function of drying the push knife 7037 is convenient and reliable. The glass slide transfer component 705 is used to transport the glass slide to the sample dropping component 702, the pusher component 703 and the second air-drying component 701 for processing respectively. The glass slide transfer component 705 and the pusher component 703 jointly complete the sample smoothing operation; the glass slide information reading and writing component 704 includes a radio frequency card reader, a radio frequency card reader mounting slot, a glass slide positioning box, and a barcode reader 8044. The radio frequency card reader is used to read and write glass slide information, and the barcode reader 8044 is used to read the barcode information on the glass slide, so as to facilitate doctors to identify patient sample information; the second air-drying component 701 includes a fan mounting plate and a turbo fan for fixing the fan. The turbo fan dries the glass slide that has completed the sample smoothing operation by blowing air. The sample dropping component 702 is composed of a sample dropping tube 7021, a first cleaning sleeve 7022 and a sample dropping motor 7023. The sample dropping tube 7021 is slidably connected to the first cleaning sleeve 7022, and the sample dropping tube 7021 is fixedly connected to the sample dropping motor 7023. The sample dropping motor 7023 controls the sample dropping tube 7021 to move up and down. When moving downward, the sample dropping tube 7021 is in a sample dropping state. When moving upward, the sample dropping tube 7021 shrinks in the first cleaning sleeve 7022 and cleans the sample dropping tube 7021. The push knife component 703 is composed of a push knife moving block 7031, a longitudinal motor drag plate 7032, a push knife longitudinal motor 7033, a push knife transverse motor 7034, and a push knife base 7035. 035, bearing 7036 and push knife 7037. The controller controls the push knife longitudinal motor 7033 to rotate, so that the longitudinal motor drag plate 7032 moves up and down. The longitudinal motor drag plate 7032 is fixedly connected to the push knife base 7035, thereby driving the push knife 7037 to move up and down, and adjusting the height of the push knife 7037; the controller controls the push knife transverse motor 7034 to move transversely, driving the push knife moving block 7031 to move left and right, and the push knife 7037 is rotationally connected to the push knife base 7035. The bearing 7036 is fixedly connected to the push knife 7037 and is slidably connected to the push knife moving block 7031. Therefore, when the push knife moving block 7031 moves left and right, the push knife 7037 rotates around the fixed axis, thereby changing the angle of the push knife 7037;The glass slide transfer component 705 is composed of a glass slide flipping assembly 70512, a push knife cleaning component 70513, a glass slide transfer guide rail 7053, a glass slide transfer motor 7051, a glass slide transfer timing belt 7052, a flip guide plate 706 and a glass slide transfer timing wheel assembly. The glass slide flipping assembly 70512 is fixed on the slider of the glass slide transfer guide rail 7053, the glass slide transfer timing belt 7052 is rotationally connected to the glass slide transfer motor 7051 through the glass slide transfer timing wheel assembly, and the glass slide transfer timing belt 7052 is connected to the slide transfer motor 7051. The slide flip assembly 70512 is fixedly connected. When the slide transfer motor 7051 rotates, it drives the slide flip assembly 70512 to move forward and backward along the guide rail 1046. The slide flip assembly 70512 is composed of a bolt-type bearing 7057, a slide flip base 7058, a slide flip shaft 7059, and a slide flip groove 70510. The slide flip groove 70510 is rotatably connected to the slide flip base 7058 through the slide flip shaft 7059. The bolt-type bearing 7057 is connected to the slide flip base 7058. The slide turning groove 70510 is fixedly connected. When the slide turning assembly 70512 moves along the slide transfer guide rail 7053 toward the turning guide plate 706, the bolt-type bearing 7057 engages with the guide groove of the turning guide plate 706, so that the slide turning groove 70510 rotates along the slide turning axis 7059, so that the slide placed in the slide turning groove 70510 changes from a horizontal state to a vertical state; the push knife cleaning component 70513 is composed of the push knife drying cotton mounting plate 7054 and the push knife cleaning component base 70 55. The push knife cleaning tank 7056 is composed of the push knife cleaning tank 7056; the push knife cleaning tank 7056 and the push knife drying cotton mounting plate 7054 are installed on the push knife cleaning component base 7055, the push knife cleaning component base 7055 and the glass slide turning base 7058 are fixedly connected, the upper end joint of the push knife cleaning tank 7056 inputs the cleaning liquid, and the bottom joint draws out the cleaning liquid. After the push knife 7037 is placed in the push knife cleaning tank 7056 and cleaned for a certain period of time, it is wiped dry by the cotton cloth on the push knife drying cotton mounting plate 7054, so as to obtain a clean push knife 7037. ;

[0052] The glass slide flipping component 104 includes a flipping transverse motor 1041, a flipping component base 1042, a first synchronous belt 1043, a synchronous belt pressure plate 1044, a first synchronous wheel 1045, a guide rail 1046, a flip bearing base 1047, a glass slide flip seat 1048 and a flip guide block 1049. The guide rail 1046 and the flipping transverse motor 1041 are respectively fixedly connected to the flipping component base 1042, the flip bearing base 1047 is fixedly connected to the guide rail 1046, the flip bearing base 1047 is rotatably connected to the glass slide flip seat 1048, the synchronous belt pressure plate 1044 is fixedly connected to the flip bearing base 1047, the first synchronous belt 1043 is fixedly connected to the flip bearing base 1047 through the synchronous belt pressure plate 1044, and the first synchronous belt 1043 is connected to the first synchronous wheel 104 5 is rotationally connected with the flipping transverse motor 1041, the flipping transverse motor 1041 drives the first synchronous belt 1043 to rotate, the first synchronous belt 1043 drives the slider of the guide rail 1046 and the flip bearing base 1047 fixed on the slider to move forward and backward, the side of the glass slide flip seat 1048 close to the flip guide block 1049 is installed with a bearing 7036, and the bearing 7036 is a bolt-type bearing, the side of the flip guide block 1049 close to the glass slide flip seat 1048 is designed with a guide groove, when the flip bearing base 1047 moves backward, the bearing 7036 of the glass slide flip seat 1048 cooperates with the guide groove of the flip guide block 1049, the glass slide flip seat 1048 is changed from a horizontal state to a vertical state, the glass slide is placed in the groove designed on the glass slide flip seat 1048, and the flip function of the glass slide is realized.

[0053] The manipulator mixing component 802 includes a third motor 8021, a fourth motor 8022, a fifth motor 8027, a vertical support plate 8028, a vertical motor bracket 80210, a horizontal motor fixing plate 80211, a second slide rail 8029, a longitudinal guide rod 80212, upper and lower sliders 8025, a mixing slider 80213, a mixing motor fixing piece 8026, a test tube clamp 80214 and a test tube clamp fixing block 8024; the fifth motor 8027 is rotatably connected to the test tube clamp fixing block 8024, and the test tube The clamp 80214 is fixedly connected to the test tube clamp fixing block 8024, and the fifth motor 8027 rotates to drive the test tube clamp 80214 and the test tube clamp fixing block 8024 to rotate. The test tube clamp 80214 holds a test tube 8023. When the test tube clamp 80214 is rotated, the test tube 8023 will also rotate, thereby mixing the blood sample in the test tube 8023; the third motor 8021 is fixedly connected to the vertical motor bracket 80210, and the upper and lower sliders 8025 and the fifth motor 8027 are respectively connected to the test tube clamp 80214 and the test tube clamp fixing block 8024. The mixing motor fixing part 8026 is fixedly connected, the third motor 8021 is slidably connected to the upper and lower sliders 8025, the third motor 8021 rotates to drive the upper and lower sliders 8025 to slide, thereby driving the test tube clamp 80214 to move up and down, simulating the action of manually taking the test tube 8023 from the test tube 8023 rack, the longitudinal guide rod 80212 is fixedly connected to the vertical motor bracket 80210, and is slidably connected to the upper and lower sliders 8025, so as to make the upper and lower sliders 8025 slide smoothly; the vertical The motor bracket 80210 is fixedly connected to the slider of the second slide rail 8029, the slide rail of the second slide rail 8029 is fixedly connected to the vertical support plate 8028, the vertical motor bracket 80210 is slidably connected to the vertical support plate 8028, the fourth motor 8022 is fixedly connected to the vertical support plate 8028, and the fourth motor 8022 rotates to drive the vertical motor bracket 80210 to move forward and backward, thereby driving the test tube clamp 80214 to move forward and backward, simulating the action of manually clamping the test tube 8023.

[0054] The first air-drying component 202 is composed of a fan support plate and a turbo fan. There are three dyeing pools 2012 placed on the dyeing pool fixing seat 2011, and there are three long needle tubes 2015 and short needle tubes 2014, one end of which is connected to the plastic tube for transporting dye and cleaning liquid, and the other end is fixed on the dyeing pool needle tube fixing seat 2013. When the dyeing pool needle tube fixing seat 2013 is fixed with screws, the three dyeing pools 2012 will be limited at the same time, so that they are fixed on the dyeing pool fixing seat 2011. When the fixing screws are removed, the long and short needle tubes 2014 and the liquid pipelines connected to them can be separated from the dyeing pool 2012, so as to achieve the purpose of quickly removing the dyeing pool 2012; the blood smear is first placed in the first dyeing pool, and the first dyeing pool is removed from the first dyeing pool. The short needle 2014 injects dye solution A, and after dyeing for a certain period of time, the long needle 2015 draws away the waste liquid of dye solution A, and then the blood smear is transferred to the second dyeing tank, and the second dyeing tank injects dye solution B from the short needle 2014. After dyeing for a certain period of time, the long needle 2015 draws away the waste liquid of dye solution B, and then the blood smear is transferred to the third dyeing tank, and the third dyeing tank injects cleaning solution from the short needle 2014. After cleaning for a certain period of time, the long needle 2015 draws away the waste liquid of cleaning solution, and finally the blood smear is transferred to the air-drying module for drying; the first air-drying component 202 has two turbo fans installed opposite to each other on the fan support plate, which can effectively air-dry one side of the blood sample slide and the back side thereof.

[0055] There are two microscope tubes 101 and two lighting components 102, one microscope is a high-magnification microscope of 100 times, and the other is a low-magnification microscope of 20 times; the CCD camera component 106 is used to collect cell image information on the glass slide, and the CCD camera component 106 includes a CCD camera, a guide rail 1046, a fixed seat, etc. The CCD camera can move to collect cell image information of high and low-magnification microscopes; the glass slide flipping component 104 includes a flipping horizontal motor 1041, a flipping component base 1042, a first synchronous belt 1043, a synchronous belt pressure plate 1044, a first synchronous wheel 1045, a guide rail 1046, a flip bearing base 1047 and a glass slide flipping seat 1048, the guide rail 1046 and the flipping horizontal motor 1041 are respectively fixedly connected to the flipping component base 1042, the flipping bearing base 1047 is fixedly connected to the guide rail 1046, and the flipping bearing base 1047 is fixedly connected to the guide rail 1046. The glass slide flip seat 1048 is rotatably connected, the synchronous belt pressure plate 1044 is fixedly connected to the flip bearing base 1047, the first synchronous belt 1043 is fixedly connected to the flip bearing base 1047 through the synchronous belt pressure plate 1044, and the first synchronous belt 1043 is rotatably connected to the flip horizontal motor 1041 through the first synchronous wheel 1045, thereby driving the sliding of the flip bearing base 1047 and the guide rail 1046. When moving in the direction of the flip horizontal motor 1041, the bearing 7036 moves along the trajectory of the flip guide plate 706, causing the glass slide flip seat 1048 to rotate, thereby changing the horizontal state and vertical state of the glass slide; the glass slide shifting component 105 is used to transfer the position of the glass slide between the XY platform component 103 and the flipping component; the XY platform component 103 provides a relatively horizontal working position for glass slide scanning, and moves the glass slide to obtain a suitable scanning trajectory.

[0056] To sum up: the fully automatic smear preparation and film reading machine has the functions of smear preparation of pushing and staining, and also has the function of reading film under microscope examination of glass slides. The functions of the two instruments are integrated into one. One instrument occupies less space in the hospital than two instruments. The sample transfer mechanism required by the two instruments is missing in the middle of the instrument. The stained blood smear can be directly examined under a microscope in one instrument, so the test results can be obtained more quickly, reducing the waiting time for doctors and patients for the results, which has a positive effect on disease detection.

[0057] What is disclosed above is only a preferred embodiment of the present invention, and it certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.

Claims

1. A fully automatic smear preparation and film reading machine, characterized in that: The invention comprises a machine frame, and a slide translation module, a slide pushing module, a staining module and a microscope module arranged on the machine frame, wherein the slide translation module comprises a slide box sample feeding component for driving the slide to be sampled, a slide box sample discharging component for driving the slide to be sampled, a slide clamping manipulator component, a slide box translation support and a lever, wherein the slide box translation support is arranged between the slide box sample feeding component and the slide box sample discharging component, the slide clamping manipulator component is arranged above the slide box translation support, and the lever is arranged at one side of the slide box translation support; The slide pushing module comprises a sample dropping component, a push knife component, a slide transfer component, a slide information reading and writing component and a slide pushing base, wherein the sample dropping component is arranged on the slide pushing base, the slide pushing base is arranged on the body frame, and the push knife component, the slide transfer component and the slide information reading and writing component are all arranged on one side of the sample dropping component; The dyeing module comprises a dyeing pool component and a first air-drying component, wherein the dyeing pool component is arranged on the body frame, and the first air-drying component is located on one side of the dyeing pool component; The microscope module comprises a microscope barrel, an illumination component, a CCD camera component, a glass slide flipping component, a glass slide shifting component and an XY platform component, wherein the illumination component is arranged below the microscope barrel, the CCD camera component is arranged above the microscope barrel, the XY platform component is placed below the microscope barrel, the glass slide flipping component is arranged above the side of the XY platform component, and the glass slide shifting component is arranged above the glass slide flipping component; The fully automatic smear preparation and film reading machine also includes a control circuit component, and the control circuit component is electrically connected to the slide translation module, the slide pushing module, the staining module and the microscope module respectively; There are two microscope tubes and two lighting components, one microscope is a 100-fold high-power microscope, and the other is a 100-fold low-power microscope; the CCD camera component is used to collect cell image information on the glass slide, and the CCD camera component includes a CCD camera, a guide rail, and a fixed seat. The CCD camera can move to collect cell image information of high- and low-power microscopes; the glass slide flipping component includes a flipping transverse motor, a flipping component base, a first synchronous belt, a synchronous belt pressure plate, a first synchronous wheel, a guide rail, a flipping bearing base and a glass slide flipping seat, the guide rail and the flipping transverse motor are respectively fixedly connected to the flipping component base, the flipping bearing base is connected to the guide rail. The guide rail is fixedly connected, the flip bearing base is rotationally connected to the glass slide flip seat, the synchronous belt pressure plate is fixedly connected to the flip bearing base, the first synchronous belt is fixedly connected to the flip bearing base through the synchronous belt pressure plate, and the first synchronous belt is rotationally connected to the flip transverse motor through the first synchronous wheel, thereby driving the sliding of the flip bearing base and the guide rail. When moving in the direction of the flip transverse motor, the bearing moves along the track of the flip guide plate, so that the glass slide flip seat rotates, thereby changing the horizontal state and vertical state of the glass slide; the glass slide shifting component is used to transfer the position of the glass slide between the XY platform component and the flip component; The XY stage assembly provides a relatively horizontal working position for slide scanning and moves the slide to obtain a suitable scanning trajectory.

2. The fully automatic smear preparation and film reading machine according to claim 1, characterized in that: The glass slide clamping robot component includes a first base, an X-direction motor, a Y-direction motor, a Z-direction motor, an X-direction guide rail, a Y-direction guide rail, a Z-direction guide rail, a mechanical claw, a mechanical claw fixing plate, a Y-direction motor guide fixing plate, and a Z-direction motor guide fixing plate. The X-direction motor and the X-direction guide rail are respectively fixedly connected to the first base, the Y-direction motor and the Y-direction guide rail are respectively fixedly connected to the Y-direction motor guide fixing plate, the Z-direction motor and the Z-direction guide rail are respectively fixedly connected to the Z-direction motor guide fixing plate, the mechanical claw is fixedly connected to the mechanical claw fixing plate, the mechanical claw fixing plate is slidably connected to the Y-direction motor guide fixing plate, the Y-direction motor guide fixing plate is slidably connected to the Z-direction motor guide fixing plate, and the Z-direction motor guide fixing plate is slidably connected to the first base.

3. The fully automatic smear preparation and film reading machine according to claim 1, characterized in that: The sample dropping component is composed of a sample dropping tube, a first cleaning sleeve and a sample dropping motor; the knife pusher component is composed of a knife pusher longitudinal motor, a knife pusher transverse motor, a knife pusher base and a knife pusher moving block; and the slide transfer component is composed of a slide flipping assembly and a knife pusher cleaning component.

4. The fully automatic smear preparation and film reading machine according to claim 3, characterized in that: The slide pushing module further comprises a flip guide plate and a second air drying component. The flip guide plate is arranged on one side of the slide transferring component, and the second air drying component is arranged on one side of the sample dropping component.

5. The fully automatic smear preparation and film reading machine according to claim 1, characterized in that: The dyeing tank component consists of a dyeing tank, a dyeing tank fixing seat, a dyeing tank needle tube fixing seat, a long needle tube, a short needle tube, a plastic tube and a cable fixing seat.

6. The fully automatic smear preparation and film reading machine according to claim 1, characterized in that: The microscope barrel comprises a barrel body, an eyepiece and an objective lens, wherein the eyepiece and the objective lens are arranged in sequence from top to bottom along the axial line direction of the barrel body, and the lighting component consists of an LED light source plate, an aperture and a lighting base.

Citation Information

Patent Citations

  • Full-automatic smear preparation and reading all-in-one machine

    CN214121740U