Electric pulse device for treating tumors

Abstract

The present disclosure relates to an electric pulse device for treating tumors. The device includes a DC power supply, a conversion circuit and a control circuit. The conversion circuit is coupled to the DC power supply and is operable to convert a DC voltage from a DC voltage into a bipolar pulse voltage. The conversion circuit includes a drive circuit, a first inverter branch and a second inverter branch connected in parallel with the first inverter branch. The first inverter branch includes a first IGBT and a second IGBT connected in series. The second inverter branch includes a third IGBT and a fourth IGBT4. The control circuit is coupled to the conversion circuit and is operable to cause the drive circuit to alternately apply a first pair of positive drive signals and a negative drive signal to the first IGBT and the second IGBT, and alternately apply a second pair of positive drive signals and a negative drive signal to the third IGBT and the fourth IGBT, so that the conversion circuit generates a bipolar pulse voltage. By using an electric pulse device according to the present disclosure, the service life of the device can be extended and possible medical accidents can be prevented.

Description

Technical Field

[0001] The present disclosure relates to the field of electronics, and more particularly to electronic medical devices. Background Art

[0002] Tumors, especially malignant tumors, are major diseases that endanger human health. Traditional tumor treatments and newly developed treatments are thermal ablation physical therapies characterized by minimally invasive ablation. Due to restrictions on indications, contraindications, treatment side effects, thermal effects and other factors, its clinical application has certain limitations. In recent years, with the continuous development of pulsed bioelectrics, electric field pulses have attracted the attention of researchers with their non-thermal and minimally invasive biomedical effects. Among them, irreversible electroporation for tumor treatment has attracted widespread attention from researchers in the field of bioelectrics at home and abroad with its advantages and characteristics such as rapidity, controllability, visibility, selectivity and non-thermal mechanism, and has gradually been applied to the clinical treatment of tumors.

[0003] Conventional devices for treating tumors output unipolar pulses, which are prone to cause muscle contraction when acting on human tissues, increasing the pain of patients and the difficulty of treatment. In addition, the electric field of unipolar pulses is uneven, resulting in ablation blind spots, which makes the ablation effect less than ideal.

[0004] In addition, conventional devices for treating tumors also have the risk of short device life and medical accidents caused by outputting unintended electrical pulses. Summary of the invention

[0005] According to an embodiment of the present disclosure, an improved apparatus for treating a tumor is provided.

[0006] In one aspect of the present disclosure, an electric pulse device for treating tumors is provided. The device includes a DC power supply, a conversion circuit and a control circuit. The conversion circuit is coupled to the DC power supply and is operable to convert a DC voltage from a DC voltage into a bipolar pulse voltage. The conversion circuit includes a drive circuit, a first inverter branch and a second inverter branch connected in parallel with the first inverter branch. The first inverter branch includes a first insulated gate bipolar transistor (IGBT) and a second IGBT connected in series. The second inverter branch includes a third IGBT and a fourth IGBT connected in series. The control circuit is coupled to the conversion circuit and is operable to cause the drive circuit to alternately apply a first pair of positive drive signals and a negative drive signal to the first IGBT and the second IGBT, and alternately apply a second pair of positive drive signals and a negative drive signal to the third IGBT and the fourth IGBT, so that the conversion circuit generates a bipolar pulse voltage. By using an electric pulse device according to the present disclosure, the service life of the device can be extended and possible medical accidents can be prevented.

[0007] It should be understood that the contents described in the summary of the invention are not intended to limit the key or important features of the embodiments of the present disclosure, nor are they intended to limit the scope of the present disclosure. Other features of the present disclosure will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. In the accompanying drawings, the same or similar reference numerals represent the same or similar elements, wherein:

[0009] Figure 1 A schematic diagram illustrating an example environment in which embodiments of the present disclosure may be implemented;

[0010] Figure 2 A partial schematic diagram according to an embodiment of the present disclosure is shown;

[0011] Figure 3 shows a conventional pulse signal schematic diagram; and

[0012] Figure 4 A pulse signal schematic diagram according to an embodiment of the present disclosure is shown. DETAILED DESCRIPTION

[0013] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments described herein, which are instead provided for a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0014] In the description of the embodiments of the present disclosure, the term "including" and similar terms should be understood as open inclusion, that is, "including but not limited to". The term "based on" should be understood as "based at least in part on". The term "one embodiment" or "the embodiment" should be understood as "at least one embodiment". The terms "first", "second", etc. may refer to different or the same objects. Other explicit and implicit definitions may also be included below.

[0015] Generally speaking, electric pulse devices used to treat tumors usually use unipolar pulses to irreversibly destroy tumor tissue. The voltage applied to the tumor tissue is usually a high voltage pulse such as 3000V, and the applied voltage value and pulse frequency can be selected accordingly based on factors such as the type, shape, size, and malignancy of the tumor.

[0016] However, conventional electric pulse devices for treating tumors have problems such as overtreatment, unsatisfactory treatment effects, and even treatment accidents. The inventors have found through research that the electric pulse signal output by conventional electric pulse devices has a spike waveform at the edge of the pulse, for example, see Figure 3 For devices used to treat tumors, these spike waveforms cause the electrical pulse device to output a voltage that exceeds the predetermined value. For treatment voltages as high as thousands of volts, these spikes may cause the peak voltage to exceed the predetermined value by hundreds of volts, which will lead to unsatisfactory treatment effects and, in severe cases, may even cause medical accidents such as irreversible damage to normal tissues.

[0017] Hereinafter, embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. Figure 1 A schematic diagram of an example environment 100 is shown in which embodiments of the present disclosure may be implemented. The example environment 100 is shown as an electrical pulse device 100 for treating a tumor.

[0018] The electric pulse device 100 includes a host computer 2, a control circuit 4, a high voltage DC power supply 6, a conversion circuit 8, a switching board 10, electrode needles 22 and 24, an auxiliary circuit, etc. Figure 1 In the figure, multiple components or circuits are schematically shown, but it is understood that this is only for illustration and does not limit the scope of the present disclosure. Figure 1 In the embodiment of the present invention, other components may be added between the components, or Figure 1 In the embodiments, some components are reduced.

[0019] The host computer 2 may be a computing device such as a computer and a tablet computer. In some examples, the host computer 2 may only include a display screen and an input device. In other examples, the host computer may only include an input device.

[0020] The control circuit 4 may include a CPU or an ARM processor. In some examples, the control circuit 4 may also be referred to as a lower circuit board or lower board relative to the upper computer 2. The control circuit 4 may be coupled to various components in the electric pulse device 100 in a wired or wireless manner as needed to receive, process and send data signals, thereby controlling various components in the electric pulse device 100.

[0021] The high-voltage DC power supply 6 can generate a required DC voltage based on a signal from the control circuit 4. For example, the high-voltage DC power supply 6 can convert a 220V AC mains voltage into a DC voltage of 800V to 3000V based on a signal from the control circuit 4. In other examples, the high-voltage DC power supply 6 can convert the AC mains voltage into a DC voltage lower than 800V such as 300V, 400V, 500V, 600V, or 700V, or convert the AC mains voltage into a DC voltage higher than 3000V such as 3100V, 3300V, 3500V, 3700V, or 4000V.

[0022] The conversion circuit 8 can convert the DC voltage from the high-voltage DC power supply 6 into a pulse voltage based on the signal from the control circuit 4. In one example, the pulse voltage is a bipolar pulse voltage. By using a bipolar pulse voltage, the problems of uneven electric field, blind ablation area, and poor ablation effect caused by a unipolar pulse voltage can be overcome, and it will not cause muscle atrophy, painful treatment, and other problems.

[0023] For example, the pulse voltage may be a bipolar pulse voltage with an amplitude of 800V and a frequency of 100Hz. In another example, the pulse voltage may be a bipolar pulse voltage with an amplitude of 3000V and a frequency of 1000Hz. In one example, a storage capacitor C1 may be provided between the conversion circuit 8 and the high-voltage DC power supply 6 so that the conversion circuit 8 obtains stable electrical energy.

[0024] Although two specific bipolar pulse voltages are schematically shown above, it is understood that this is only for illustration and does not limit the scope of the present disclosure. For example, the amplitude and frequency of the bipolar pulse voltage can be selected based on factors such as the type, shape, size, and malignancy of the tumor being targeted.

[0025] The switching board 10 is coupled to the conversion circuit 8 and the control circuit 4 via the load resistor R2, and selectively switches the pulse voltage between the electrode needles 22 and 24 according to the control signal of the control circuit 4. The switching board 10 includes a first plate 102 and a second plate 104. Different potentials are applied between the first plate 102 and the second plate 104, so that a voltage is formed between the two. The direction between the first plate 102 and the second plate 104 can be reversed according to the pulse waveform as needed.

[0026] The switching board 10 includes a first switch 106 and a second switch 108. The first switch 106 and the second switch 108 are coupled to the control circuit 4 and controlled by the control circuit 4. In one example, the first switch 106 and the second switch 108 can be relays. By connecting the first switch 106 and the second switch 108 to boards with different potentials, a high voltage electric field can be formed between the electrode needles 22 and 24.

[0027] Although in Figure 1 Only two electrode needles are shown in the embodiment, but it is understood that this is only an example and not a limitation on the scope of the present disclosure. Based on factors such as the type, shape, size, and malignancy of the tumor being targeted, more electrode needles can be selected, such as four electrode needles, including two electrode needles with high potential and two electrode needles with low potential. In another example, five, seven, or eight electrode needles can be selected, and the potential of each electrode needle can be different.

[0028] exist Figure 1 In the embodiment of the present invention, the electric pulse device 100 further has a discharge resistor R1. The discharge resistor R1 is coupled between the high-voltage DC power supply 6 and the conversion circuit 8, and is operable to discharge the accumulated energy in the event of an emergency stop. During the operation of the electric pulse device 100, a doctor or user may need to perform an emergency stop operation, i.e., an emergency stop, on the electric pulse device 100 with high voltage electricity due to an emergency.

[0029] Therefore, in one embodiment of the present disclosure, the electric pulse device 100 also has an emergency stop switch device. The emergency stop switch device may include, for example, a first switch S1, a second switch S2, a third switch S3, and a fourth switch S4. The emergency stop switch device is coupled to a high-voltage DC power supply through the fourth switch S4, coupled to a discharge resistor through the first switch S1, and coupled to the conversion circuit 8 through the second switch S2 and the third switch S4.

[0030] The emergency stop switch device is operable to disconnect the electrical connection between the high-voltage DC power supply 6 and the conversion circuit 8 by disconnecting the second switch S2 and the third switch S3 in response to the emergency stop switch being turned on (for example, the mechanical button is pressed), shut down the high-voltage DC power supply 6 by closing the fourth switch S4, and discharge the energy by closing the first switch S1 to turn on the discharge resistor R1. In one example, the discharge resistor R1 can be turned on by closing the first switch S1 after a certain period of time after the high-voltage DC power supply 6 is turned off to discharge the energy.

[0031] exist Figure 1In the example, the electric pulse device 100 also includes a foot switch S5 coupled between the switching board 10 and the conversion circuit 8. When a doctor or user uses the electric pulse therapy device, it is not desired that the electrode needle always applies an electric field, but only applies the electric field during treatment. In some examples, even during treatment, it is not desired that the electrode needle always applies an electric field, but only applies the electric field when the electrode needle is in place (for example, inserted into a specific position in human tissue). Therefore, a switch is needed to control the application of the electric field. Compared to conventional hand-pressed switches, the use of a foot switch S5 can prevent the doctor from touching the switch with his hand during treatment, resulting in bacterial contamination, thereby avoiding the risk of infection to the wound. In addition, by using the foot switch S5, the doctor does not need to rely on an outsider to control the switch, making treatment more convenient.

[0032] Figure 2 A partial schematic diagram of an embodiment of the present disclosure is shown. For ease of understanding and description, Figure 1 Some components in the present invention are not shown here to avoid affecting the description of important components. Figure 1 Some of the components in Figure 2 In the embodiments, it does not exist or can be omitted.

[0033] The high voltage DC power supply 6 provides a DC voltage V to the conversion circuit 8. A The conversion circuit 8 includes a drive circuit 80 and an inverter circuit. The inverter circuit includes a first inverter branch and a second inverter branch. The first inverter branch includes a high voltage terminal V A and ground voltage terminal V B The first IGBT S1 and the second IGBT S2 are coupled in series, and the second inverter branch includes a high voltage terminal V A and ground voltage terminal V B The third IGBT S3 and the fourth IGBT S4 are coupled in series therebetween.

[0034] The control circuit 4 sends a control signal to the drive circuit 80, so that the drive circuit 80 controls the turning on and off of the IGBTs in the inverter circuit. For example, at one moment, the drive circuit 80 turns on the first IGBT S1 and the fourth IGBT S4, and turns off the second IGBT S2 and the third IGBT S3, so that a high voltage is applied to the first board of the switching board 10, and a low voltage is applied to the first board of the switching board 10. At the next moment, the drive circuit turns on the second IGBT S2 and the third IGBT S3, and turns off the first IGBT S1 and the fourth IGBT S4, so that a low voltage is applied to the first board of the switching board 10, and a high voltage is applied to the first board of the switching board 10.

[0035] However, the inventors have found through research that when the IGBT is switched, there is a situation where the upper IGBT and the lower IGBT are turned on simultaneously for a short time. For example, the first IGBT S1 and the second IGBT S2 are turned on simultaneously, which causes a short circuit in the first inverter branch. This is because the parasitic capacitance between the gate and the collector of the IGBT will produce a very high transient voltage change (dv / dt) during the IGBT shutdown period, which will cause the voltage between the gate and the collector to increase and turn on the IGBT.

[0036] Although this short circuit is relatively short-lived, it will still cause glitches or spikes in the waveform output by the electrode needle. Figure 3 A schematic diagram of this type of conventional pulse signal is shown in FIG. Figure 3 It can be seen from the figure that at the beginning of the pulse jump, there is a small pulse spike. This small pulse spike can be hundreds or even thousands of volts in high voltage applications such as electric pulse tumor therapeutic devices. This unexpected high voltage may cause normal cells to be irreversibly damaged.

[0037] In addition, for the electric pulse therapy device, since the upper and lower IGBTs are turned on at the same time to form a short circuit, the short circuit will generate considerable heat, thereby affecting the service life of the inverter circuit. In severe cases, the short circuit may even cause the IGBT to crash and cannot continue to be used.

[0038] In response to the above problem, in one embodiment of the present disclosure, the drive circuit 80, in response to the control signal of the control circuit 4, alternately applies the first pair of positive drive signals and negative drive signals to the first IGBT S1 and the second IGBT S2, and alternately applies the second pair of positive drive signals and negative drive signals to the third IGBT S3 and the fourth IGBT S4, so that the conversion circuit generates a bipolar pulse voltage.

[0039] For example, at one moment, the drive circuit 80 provides a voltage of +15V to the first IGBT S1, a voltage of -5V to the second IGBT S2, a voltage of -5V to the third IGBT S3, and a voltage of +15V to the fourth IGBT S4. At the next moment when the pulse signal jumps, the drive circuit 80 provides a voltage of -5V to the first IGBT S1, a voltage of +15V to the second IGBT S2, a voltage of +15V to the third IGBT S3, and a voltage of -5V to the fourth IGBT S4, and thus alternately reciprocates.

[0040] Although +15V and -5V are used as examples for explanation above, this is only for illustration and not for limiting the scope of the present disclosure. In one example, the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range of 0V to +18V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from the range of 0V to -8V.

[0041] In another example, the positive drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to +15V, and the negative drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to -5V.

[0042] In yet another example, the positive drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to +15V, and the negative drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to -8V.

[0043] In yet another example, the positive drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to +18V, and the negative drive signal in the first pair of positive and negative drive signals is selected from a range from 0V to -5V.

[0044] By using a pair of positive and negative drive signals to apply to the inverter branch, the short circuit problem caused by the upper IGBT and the lower IGBT being turned on at the same time can be effectively prevented, and the pulse waveform output by the electrode needle can be more ideal accordingly. Figure 4 As shown, the pulse waveform is smooth and complete without any transient glitches or spikes.

[0045] Although in the embodiments of the present disclosure, a pair of positive and negative drive signals are applied to the inverter branch to prevent the short circuit problem caused by the upper IGBT and the lower IGBT being turned on at the same time, it can be understood that this is only an example and does not limit the scope of the present disclosure. In some other examples, the short circuit problem caused by the upper IGBT and the lower IGBT being turned on at the same time can be prevented by increasing the gate resistance of the IGBT, the capacitance between the gate and the collector of the IGBT, or providing an additional transistor between the gate and the emitter of the IGBT.

[0046] In addition, the control circuit 4 is operable to receive a first input indicating a voltage, and adjust the DC power supply to generate an adjusted DC voltage based on the received first input. For example, for a specific type of tumor, a voltage value can be input to the control circuit 4 through the host computer 2 accordingly, and the control circuit 4 receives the input, and based on the received input, the conversion circuit 8 adjusts the value of the bipolar pulse voltage, for example, from 1000V to 1500V.

[0047] In one example, the conversion circuit 80 further includes a voltage detection device 82. The voltage detection device 82 is operable to detect a DC voltage. Figure 2 The conversion circuit 80 is shown to include a voltage detection device 82 , but it is understood that this is only for illustration and does not limit the protection scope of the present disclosure. The voltage detection device 82 may exist independently of the conversion circuit 80 .

[0048] For example, a separate voltage detection device 82 may be provided to detect the DC voltage of the emitter and collector of the IGBT, and transmit the detected voltage to the control circuit 4. The control circuit 4 is operable to receive the detected DC voltage, determine that the detected DC voltage exceeds a threshold value, and in response to the detected DC voltage exceeding the threshold value, cause the drive circuit 80 to turn off the first IGBT S1, the second IGBT S2, the third IGBT S3, and the fourth IGBT S4.

[0049] For example, when the detected DC voltage exceeds the 7V threshold, the voltage detection device 82 determines that the DC voltage exceeds the threshold and a short circuit exists in this case. The drive circuit 80 turns off the first IGBT S1, the second IGBT S2, the third IGBT S3 and the fourth IGBT S4 to protect the inverter circuit from collapse.

[0050] Although in Figure 2 In the example of FIG. 8 , the protection circuit is shown as a part of the drive circuit, but it can be understood that this is only an example and not a limitation of the protection scope of the present disclosure. In some other examples, a separate protection circuit can be provided, and when the voltage detection device 82 determines that the DC voltage exceeds the threshold and there is a short circuit in this case, the drive circuit 80 enables the separate protection circuit to turn off the first IGBT S1, the second IGBT S2, the third IGBT S3 and the fourth IGBT S4 to protect the inverter circuit from collapse.

[0051] In one example, the control circuit 4 is operable to receive a second input indicating a frequency, and based on the received second input, the conversion circuit 8 adjusts the frequency of the bipolar pulse voltage. For example, for a specific type of tumor, the frequency value can be input to the control circuit 4 through the host computer 2 accordingly, and the control circuit 4 receives the input, and based on the received input, the conversion circuit 8 adjusts the frequency of the bipolar pulse voltage, for example, from 100 Hz to 150 Hz.

[0052] The above generally describes the electric pulse device for treating tumors according to the embodiments of the present disclosure. Some exemplary embodiments according to the present disclosure are listed below.

[0053] Item 1: An electric pulse device for treating tumors is provided. The electric pulse device includes a DC power supply; a conversion circuit coupled to the DC power supply and operable to convert a DC voltage from a DC voltage into a bipolar pulse voltage, the conversion circuit includes a drive circuit, a first inverter branch and a second inverter branch connected in parallel with the first inverter branch, the first inverter branch includes a first IGBT and a second IGBT connected in series, and the second inverter branch includes a third IGBT and a fourth IGBT; and a control circuit coupled to the conversion circuit and operable to enable the drive circuit to alternately apply a first pair of positive drive signals and a negative drive signal to the first IGBT and the second IGBT, and alternately apply a second pair of positive drive signals and a negative drive signal opposite to the first pair of positive drive signals and negative drive signals to the third IGBT and the fourth IGBT4, so that the conversion circuit generates a bipolar pulse voltage.

[0054] Item 2: An electric pulse device according to Item 1, wherein the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range of 0V to +18V, and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from the range of 0V to -8V.

[0055] Item 3: An electric pulse device according to Item 1, wherein the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +15V; and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to -5V.

[0056] Item 4: An electric pulse device according to Item 1, wherein the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +15V; and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to -8V.

[0057] Item 5: An electric pulse device according to Item 1, wherein the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +18V; and the negative drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to -5V.

[0058] Item 6: The electro-pulse device of Item 1, wherein the control circuit is operable to receive a first input indicative of a voltage, and to adjust the DC power source to generate a regulated DC voltage based on the received first input.

[0059] Item 7: An electric pulse device according to Item 1, wherein the conversion circuit further comprises a voltage detection device, the voltage detection device being operable to detect a DC voltage.

[0060] Item 8: An electric pulse device according to Item 7, wherein the control circuit is operable to: receive a detected DC voltage; determine that the detected DC voltage exceeds a threshold; and in response to the detected DC voltage exceeding the threshold, cause the drive circuit to turn off the first insulated gate bipolar transistor, the second insulated gate bipolar transistor, the third insulated gate bipolar transistor, and the fourth insulated gate bipolar transistor.

[0061] Item 9. The electrical pulse device of Item 6, wherein the control circuit is operable to receive a second input indicative of a frequency, and to cause the conversion circuit to adjust the frequency of the bipolar pulse voltage based on the received second input.

[0062] Item 10. The electric pulse device according to Item 1 further comprises: a discharge resistor coupled between the DC power supply and the conversion circuit and operable to discharge energy in the event of an emergency stop; and an emergency stop switch device coupled to the DC power supply, the discharge resistor and the conversion circuit, and the emergency stop switch device is operable to disconnect the electrical connection between the DC power supply and the converted circuit in response to the emergency stop switch being turned on; turn off the DC power supply; and discharge the energy through the discharge resistor.

[0063] Although the subject matter has been described in language specific to structural features and / or methodological logical actions, it should be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or actions described above. On the contrary, the specific features and actions described above are merely example forms of implementing the claims.

Claims

1. An electric pulse device for treating tumors, comprising: DC power supply (6); A conversion circuit (8) coupled to the DC power supply and operable to convert a DC voltage from the DC power supply into a bipolar pulse voltage, the conversion circuit comprising a drive circuit (80), a first inverter branch and a second inverter branch connected in parallel with the first inverter branch, the first inverter branch comprising a first insulated gate bipolar transistor IGBT1 and a second insulated gate bipolar transistor IGBT2 connected in series, the second inverter branch comprising a third insulated gate bipolar transistor IGBT3 and a fourth insulated gate bipolar transistor IGBT4 connected in series; as well as A control circuit (4) is coupled to the conversion circuit and is operable to cause the drive circuit to alternately apply a first pair of positive drive signals and a negative drive signal to the first insulated gate bipolar transistor IGBT1 and the second insulated gate bipolar transistor IGBT2, and to alternately apply a second pair of positive drive signals and a negative drive signal opposite to the first pair of positive drive signals and the negative drive signal to the third insulated gate bipolar transistor IGBT3 and the fourth insulated gate bipolar transistor IGBT4, so that the conversion circuit (8) generates the bipolar pulse voltage.

2. The electric pulse device according to claim 1, wherein the positive drive signal in the first pair of positive drive signals and negative drive signals is selected from the range from 0V to +18V, and The negative driving signal of the first pair of positive driving signal and negative driving signal is selected from a range from 0V to -8V.

3. The electric pulse device according to claim 1, wherein the positive drive signal in the first pair of positive drive signal and negative drive signal is selected from the range from 0V to +15V; and The negative driving signal of the first pair of positive driving signal and negative driving signal is selected from a range from 0V to -5V.

4. The electric pulse device according to claim 1, wherein the positive drive signal in the first pair of positive drive signal and negative drive signal is selected from the range from 0V to +15V; and The negative driving signal of the first pair of positive driving signal and negative driving signal is selected from a range from 0V to -8V.

5. The electric pulse device according to claim 1, wherein the positive drive signal in the first pair of positive drive signal and negative drive signal is selected from the range from 0V to +18V; and The negative driving signal of the first pair of positive driving signal and negative driving signal is selected from a range from 0V to -5V.

6. The electropulse device of claim 1, wherein the control circuit is operable to receive a first input indicative of a voltage and to adjust the DC power source to generate the adjusted DC voltage based on the received first input.

7. The electric pulse device according to claim 1, wherein the conversion circuit further comprises a voltage detection device, the voltage detection device being operable to detect the DC voltage.

8. The electrical pulse device of claim 6, wherein the control circuit is operable to: receiving the detected DC voltage; determining that the detected DC voltage exceeds a threshold; and In response to the detected DC voltage exceeding a threshold value, the drive circuit turns off the first insulated gate bipolar transistor IGBT1 , the second insulated gate bipolar transistor IGBT2 , the third insulated gate bipolar transistor IGBT3 and the fourth insulated gate bipolar transistor IGBT4 .

9. The electrical pulse device of claim 6, wherein the control circuit is operable to receive a second input indicative of a frequency, and to cause the conversion circuit to adjust the frequency of the bipolar pulse voltage based on the received second input.

10. The electric pulse device according to claim 1, further comprising: a discharge resistor coupled between the DC power supply and the conversion circuit and operable to discharge energy in the event of an emergency stop; as well as An emergency stop switch device is coupled to the DC power supply, the bleeder resistor and the conversion circuit, and the emergency stop switch device can be operated as follows: In response to the emergency stop switch being turned on, disconnecting the electrical connection between the DC power supply and the converted circuit; Turning off the DC power supply; and The energy is discharged through the discharge resistor.

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