A personalized corneal cross-linking system

Abstract

A personalized corneal cross-linking system includes an information acquisition module, a personalized cross-linking scheme selection module, a multi-level corneal personalized customization module, and an eyeball clock position calibration module; the information acquisition module collects the patient's preoperative detection information and intraoperative eyeball clock position information, the preoperative detection information includes a corneal topography quadruple map and corneal OCT detection data, the personalized cross-linking scheme selection module selects a corresponding personalized cross-linking scheme according to the patient's treatment needs, the multi-level corneal cross-linking personalized customization module generates a personalized cross-linking pattern and a cross-linking energy distribution topography map according to the selected personalized cross-linking scheme and the information collected by the information acquisition module, and determines the cross-linking treatment method, and the eyeball clock position calibration module provides intraoperative eyeball clock position calibration to rotate the personalized cross-linking image to a corresponding angle according to the intraoperative eyeball rotation angle in the plane. The system has the advantages of high customization, adjustable according to actual needs, high accuracy, wide application range, and convenient operation.

Description

Technical Field

[0001] The invention relates to ophthalmic medical surgical equipment, in particular to a personalized corneal cross-linking system. Background Art

[0002] The cornea is a transparent tissue at the front of the eyeball. It plays an important role in the eye. It contributes more than 60% to the refractive power of the eyeball system. Changes in the shape of the cornea can cause significant changes in vision. Myopia, hyperopia, astigmatism and keratoconus are all eye diseases that involve changes in the tissues of the eyeball system. By changing the refractive power of the cornea, the condition can be alleviated and have a certain effect on improving vision.

[0003] Corneal collagen cross-linking is the latest corneal shaping technology used in clinical practice in the early 21st century. Riboflavin is used as a photosensitizer to locally irradiate the cornea with 370nm ultraviolet light to increase the hardness of the cornea. Corneal cross-linking has been gradually carried out in China in recent years, and has shown good efficacy in preventing the progression of keratoconus. Corneal cross-linking is the use of light to trigger the cross-linking reaction of collagen in corneal tissue. Corneal tissue includes a large amount of collagen, mainly type I collagen. Existing findings show that collagen tissue will undergo collagen reaction under optical catalysis. Collagen cross-linking will promote the enhancement of the tissue properties of collagen tissue, and will have a corresponding effect on the tissue structure and mechanical properties of the cornea, thereby affecting the refractive properties of the cornea.

[0004] It should be noted that the information disclosed in the above background technology section is only used for understanding the background of the present application, and therefore may include information that does not constitute prior art known to ordinary technicians in the field. Summary of the invention

[0005] The main purpose of the present invention is to provide a personalized corneal cross-linking system to address the problems existing in the above-mentioned background technology.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A personalized corneal cross-linking system comprises an information acquisition module, a personalized cross-linking scheme selection module, a multi-level corneal personalized customization module and an eye clock position calibration module; wherein the information acquisition module is used to acquire the patient's preoperative detection information and intraoperative eye clock position information, the preoperative detection information comprises a corneal topography quadruple map and corneal OCT detection data, the personalized cross-linking scheme selection module is used to select a corresponding personalized cross-linking scheme according to the patient's treatment needs, the multi-level corneal cross-linking personalized customization module is used to generate a personalized cross-linking pattern and a cross-linking energy distribution topography map according to the selected personalized cross-linking scheme and the corneal topography quadruple map and the corneal OCT detection data acquired by the information acquisition module, and determine the cross-linking treatment method, and the eye clock position calibration module is used to provide intraoperative eye clock position calibration to rotate the personalized cross-linking image by a corresponding angle according to the intraoperative rotation angle of the eye in the plane.

[0008] Further:

[0009] The multi-level corneal cross-linking personalized customization module processes the corneal topography, obtains the cross-linking energy distribution map from the corneal topography characterizing the corneal thickness in the corneal topography quadruple map, generates the personalized cross-linking pattern from the corneal anterior surface curvature topography and the corneal posterior surface curvature topography in the corneal topography quadruple map, and determines the cross-linking method based on the cross-linking energy distribution map and the personalized cross-linking pattern; wherein, the cross-linking energy distribution map represents the maximum energy that can be used at each position of the patient's cornea, and the personalized cross-linking pattern corresponds to the patient's corneal lesion area, i.e., the treatment area.

[0010] The personalized cross-linking scheme selection module also includes providing a honeycomb pattern or a bird's nest pattern for selection, using the selected pattern as the basis of the personalized cross-linking scheme, and combining the information collected by the information collection module to generate the personalized cross-linking pattern.

[0011] The multi-level corneal cross-linking personalized customization module is also used to generate a personalized treatment enhancement plan, wherein the personalized treatment enhancement plan is based on the corneal topography. Figure 4 The anterior corneal surface curvature topography and the posterior corneal surface curvature topography in the joint image are processed to obtain the personalized treatment enhancement plan, including the area where the corneal curvature is too large in the local position and needs to be treated intensively.

[0012] The selectable personalized cross-linking schemes specifically include: a cross-linking treatment method that is personalized only with the cross-linking pattern, a cross-linking treatment method that is dual-personalized with the cross-linking pattern and the cross-linking energy, and a fully personalized cross-linking treatment method. The cross-linking treatment method that is personalized only with the cross-linking pattern is a cross-linking treatment method that only uses the generated personalized cross-linking pattern, the cross-linking treatment method that is dual-personalized with the cross-linking pattern and the cross-linking energy is a method that uses the sum of the generated cross-linking energy distribution map and the personalized cross-linking pattern, and the fully personalized cross-linking treatment method is a method that uses the sum of the generated cross-linking energy distribution map, the personalized cross-linking pattern, and the treatment enhancement personalized plan.

[0013] The eye clock position calibration module automatically identifies the rotation angle of the eyeball in the plane during the operation according to the preoperative and intraoperative eye clock position information collected by the information collection module, and controls the personalized cross-linking image to rotate to the same angle.

[0014] Feature points are set for the image of the eyeball when the patient is in a normal position, and the eyeball clock position calibration module captures the corresponding feature points in real time during the intraoperative treatment position, calculates the corresponding clock position angle, and controls the generated personalized cross-linking pattern to rotate to a corresponding angle to adapt to the rotation of the eyeball.

[0015] The eyeball clock position calibration module controls the personalized cross-linking image to rotate to a corresponding angle according to the eyeball clock position rotation information input by the user.

[0016] The information acquisition module performs real-time pupil tracking, and determines the rotation angle of the eyeball in a plane through real-time pupil rotation measurement, which serves as a basis for the eyeball clock position calibration module to perform eyeball clock position calibration.

[0017] The corneal OCT detection data includes anterior segment OCT detection data.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The personalized corneal cross-linking system of the present invention supports doctors to select different personalized customization methods according to the actual needs of patients. The data acquired by the information acquisition system generates customized cross-linking patterns, cross-linking energy distribution, and cross-linking methods. In addition, by introducing a mechanism for real-time calibration of the ocular clock rotation, the accuracy of personalized corneal cross-linking is improved. The personalized corneal cross-linking system has the advantages of high degree of customization, adjustable according to actual needs, high accuracy, wide application range, and convenient operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 4 is a structural block diagram of a personalized corneal cross-linking system according to an embodiment of the present invention.

[0021] Figure 2Schematic diagram of a multi-level cornea personalized customization module according to an embodiment of the present invention.

[0022] Figure 3 Schematic diagram of eye clock position calibration according to an embodiment of the present invention.

[0023] Figure 4 Examples of patterns that can be selected to generate a personalized corneal cross-linking pattern. DETAILED DESCRIPTION

[0024] The following is a detailed description of the embodiments of the present invention. It should be emphasized that the following description is only exemplary and is not intended to limit the scope and application of the present invention.

[0025] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element. In addition, connection can be used for fixing as well as for coupling or communication.

[0026] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0027] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the embodiments of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0028] See also Figures 1 to 3In one embodiment, a personalized corneal cross-linking system includes an information acquisition module, a personalized cross-linking scheme selection module, a multi-level corneal personalized customization module, and an eye clock position calibration module; wherein the information acquisition module is used to collect the patient's preoperative detection information and intraoperative eye clock position information, the preoperative detection information includes a corneal topography quadruple map and corneal OCT detection data, the personalized cross-linking scheme selection module is used to select a corresponding personalized cross-linking scheme according to the patient's treatment needs, the multi-level corneal cross-linking personalized customization module is used to generate a personalized cross-linking pattern and a cross-linking energy distribution topography map according to the selected personalized cross-linking scheme and the corneal topography quadruple map and the corneal OCT detection data collected by the information acquisition module, and determine the cross-linking treatment method by the personalized cross-linking pattern, or determine the cross-linking treatment method by the personalized cross-linking pattern & cross-linking energy distribution topography together, and the eye clock position calibration module is used to provide intraoperative eye clock position calibration, so as to rotate the personalized cross-linking image by the same angle according to the intraoperative eye rotation angle in the plane, and calibrate the eye rotation to ensure the accuracy of personalized corneal cross-linking.

[0029] In a preferred embodiment, the multi-level corneal cross-linking personalized customization module processes the corneal topography, obtains the cross-linking energy distribution map from the corneal topography characterizing the corneal thickness in the corneal topography quadruple map, generates the personalized cross-linking pattern from the corneal anterior surface curvature topography and the corneal posterior surface curvature topography in the corneal topography quadruple map, and determines the cross-linking mode by the cross-linking energy distribution map and the personalized cross-linking pattern; wherein, the cross-linking energy distribution map represents the maximum energy that can be used at each position of the patient's cornea, and the personalized cross-linking pattern corresponds to the patient's corneal lesion area, i.e., the treatment area.

[0030] See also Figure 2 In a preferred embodiment, the multi-level corneal cross-linking personalized customization module is also used to generate a personalized treatment enhancement plan, wherein the personalized treatment enhancement plan is based on the corneal topography. Figure 4 The anterior corneal surface curvature topography and the posterior corneal surface curvature topography in the joint image are processed to obtain the personalized treatment enhancement plan, including the area where the corneal curvature is too large in the local position and needs to be treated intensively.

[0031] like Figure 2As shown, in a preferred embodiment, the selectable personalized cross-linking schemes specifically include: a cross-linking treatment method that is personalized only for the cross-linking pattern, a cross-linking treatment method that is dual-personalized for the cross-linking pattern and the cross-linking energy, and a fully personalized cross-linking treatment method. The cross-linking treatment method that is personalized only for the cross-linking pattern is a cross-linking treatment method that only uses the generated personalized cross-linking pattern, the cross-linking treatment method that is dual-personalized for the cross-linking pattern and the cross-linking energy is a method that uses the sum of the generated cross-linking energy distribution map and the personalized cross-linking pattern, and the fully personalized cross-linking treatment method is a method that uses the sum of the generated cross-linking energy distribution map, the personalized cross-linking pattern, and the treatment enhancement personalized scheme.

[0032] In a preferred embodiment, the eye clock position calibration module automatically calculates and identifies the intraoperative rotation angle of the eye in the plane based on the preoperative and intraoperative eye clock position information collected by the information collection module, and controls the personalized cross-linking image to rotate to the same angle.

[0033] See also Figure 3 In a more preferred embodiment, feature points are set for the image of the eyeball when the patient is in a normal position, and the eyeball clock position calibration module captures the corresponding feature points in real time during the intraoperative treatment position, calculates the corresponding clock position angle, and controls the generated personalized cross-linking pattern to rotate to a corresponding angle to adapt to the rotation of the eyeball.

[0034] In another embodiment, the eye clock position calibration module may also control the personalized cross-linking image to rotate to a corresponding angle according to the eye clock position rotation information input by a user (such as a doctor).

[0035] In a preferred embodiment, the information acquisition module performs real-time pupil tracking, determines the rotation angle of the eyeball in a plane through real-time pupil rotation measurement, and serves as a basis for the eyeball clock position calibration module to perform eyeball clock position calibration.

[0036] See also Figure 4 In a preferred embodiment, the personalized cross-linking scheme selection module also includes providing a honeycomb pattern or a bird's nest pattern for selection, using the selected pattern as the basis of the personalized cross-linking scheme, and combining the information collected by the information collection module to generate the personalized cross-linking pattern.

[0037] The corneal OCT detection data may include anterior segment OCT detection data.

[0038] The following further describes specific embodiments of the present invention and its medical applications by way of examples.

[0039] like Figure 1As shown, the personalized corneal cross-linking system of the embodiment of the present invention includes a multi-level corneal cross-linking personalized customization module 11, a personalized cross-linking scheme selection module 12, an eyeball clock position calibration module 13 and an information collection module 14. In the embodiment of the present invention, the doctor can import the patient's preoperative test results in advance through the information collection module 14, and select personalized cross-linking schemes of different levels through the personalized cross-linking scheme selection module 12. The multi-level corneal cross-linking personalized customization module 12 generates a corresponding personalized corneal cross-linking scheme, and the eyeball clock position calibration module 13 is responsible for calibrating the eyeball rotation during the treatment process to ensure the accuracy of personalized corneal cross-linking.

[0040] like Figure 1 As shown, the information acquisition module 14 collects the patient's corneal topography, corneal OCT and other detection data before the operation, and collects the clock position information of the eyeball rotation in real time during the operation.

[0041] like Figure 1 and Figure 2 As shown, the multi-level corneal cross-linking personalized customization module 11 can generate a cross-linking energy distribution map 21, a personalized cross-linking pattern 22 and a personalized treatment enhancement plan 23 based on the corneal topography, corneal OCT and other data obtained from the information acquisition module 14. The cross-linking energy distribution map 21 is composed of the corneal topography, Figure 4 The corneal thickness topography in the joint image is processed, and the personalized cross-linking pattern 22 and the personalized treatment enhancement plan 23 are obtained by the corneal topography. Figure 4 The anterior corneal surface curvature topography and the posterior corneal surface curvature topography in the joint image are processed.

[0042] like Figure 2 As shown, the cross-linking energy distribution topography 21 is the maximum energy that can be used at each position of the patient's cornea, which is determined by the corneal topography. Figure 4 The corneal thickness topography in the joint image is processed to show that the thicker the cornea, the greater the maximum energy allowed, and the thinner the cornea, the smaller the maximum energy allowed.

[0043] like Figure 2 , Figure 4 As shown, the personalized cross-linking pattern 22 is the patient's corneal lesion area, that is, the treatment area, which is determined by the corneal topography. Figure 4 The anterior corneal curvature topography and the posterior corneal curvature topography in the combined image are processed, and the area with excessive corneal curvature is the lesion area, such as the circular area in the cornea in the figure. When generating a personalized corneal cross-linking pattern, the doctor can use the "honeycomb" 41, "bird's nest" 42 and other patterns attached to the system.

[0044] like Figure 2 As shown, treatment enhancement and personalized regimen 23 are determined by corneal topography Figure 4The anterior corneal curvature topography and posterior corneal curvature topography in the joint image are processed to show the area where the corneal curvature is too large and needs to be treated intensively, as shown in the black solid part of the cornea.

[0045] The personalized cross-linking scheme selection module 12 supports doctors to select personalized cross-linking schemes of different degrees according to the patient's treatment needs, etc. The personalized cross-linking schemes are divided into three levels according to the patient's disease location, condition and treatment needs, namely, the treatment method of personalized pattern only, the dual personalized treatment of cross-linking pattern & cross-linking energy and the full personalized treatment.

[0046] The first-level personalized pattern-only treatment method is a method that uses only the generated personalized cross-linking pattern 21 .

[0047] The second level cross-linking pattern & cross-linking energy dual personalized treatment 24 is a method of adding the generated cross-linking energy distribution topography and the personalized cross-linking pattern.

[0048] The third level of fully personalized treatment 25 is a combination of the generated cross-linking energy distribution topography, the personalized cross-linking pattern and the personalized treatment enhancement plan.

[0049] The eye clock position calibration module 13 is designed to address the corneal rotation problem caused by the different positions of the patient during preoperative examination and intraoperative treatment. The eye clock position calibration module supports manual and automatic modes of eye clock position calibration.

[0050] The automatic mode can automatically identify the rotation angle of the eyeball in the plane according to the intraoperative eyeball clock position information collected by the information acquisition module, and control the personalized cross-linking image to rotate to the same angle. In the manual mode, when the doctor independently measures the eyeball clock position rotation information and inputs it into the system, the system controls the personalized cross-linking image to rotate to the corresponding angle.

[0051] The automatic mode of the eye clock position calibration module will automatically set the feature points 31 when the patient is in a normal position. In some embodiments, the feature points may be set in other distribution modes.

[0052] The automatic mode of the eye clock position calibration module will capture the corresponding feature points 32 in real time during the treatment position, calculate the corresponding clock position angle 33, and control the generated personalized corneal cross-linking scheme to rotate the corresponding angle to adapt to the eye rotation, thereby ensuring the accuracy of personalized treatment.

[0053] The background section of the present invention may contain background information about the problem or environment of the present invention, but does not necessarily describe the prior art. Therefore, the content included in the background section is not an admission by the applicant that the prior art is available.

[0054] The above content is a further detailed description of the present invention in combination with specific / preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, without departing from the concept of the present invention, it can also make several substitutions or modifications to these described embodiments, and these substitutions or modifications should be regarded as belonging to the protection scope of the present invention. In the description of this specification, the description of the reference terms "an embodiment", "some embodiments", "preferred embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily target the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In the absence of mutual contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples. Although the embodiments of the present invention and their advantages have been described in detail, it should be understood that various changes, substitutions and modifications can be made herein without departing from the scope of protection of the patent application.

Claims

1. A personalized corneal cross-linking system, characterized in that: It includes an information acquisition module, a personalized cross-linking scheme selection module, a multi-level corneal personalized customization module and an eyeball clock position calibration module; wherein the information acquisition module is used to collect the patient's preoperative detection information and intraoperative eyeball clock position information, the preoperative detection information includes a corneal topography quadruple map and corneal OCT detection data, the personalized cross-linking scheme selection module is used to select a corresponding personalized cross-linking scheme according to the patient's treatment needs, the multi-level corneal cross-linking personalized customization module is used to generate a personalized cross-linking pattern and a cross-linking energy distribution topography map according to the selected personalized cross-linking scheme and the corneal topography quadruple map and the corneal OCT detection data collected by the information acquisition module, and determine the cross-linking treatment method, the eyeball clock position The calibration module is used to provide intraoperative eye clock position calibration so as to rotate the personalized cross-linking image by a corresponding angle according to the rotation angle of the eye in the plane during the operation. The multi-level corneal cross-linking personalized customization module processes the corneal topography, obtains the cross-linking energy distribution map from the corneal topography characterizing the corneal thickness in the corneal topography quadruple map, generates the personalized cross-linking pattern from the corneal anterior surface curvature topography and the corneal posterior surface curvature topography in the corneal topography quadruple map, and determines the cross-linking mode by the cross-linking energy distribution map and the personalized cross-linking pattern; wherein, the cross-linking energy distribution map represents the maximum energy that can be used at each position of the patient's cornea, and the personalized cross-linking pattern corresponds to the patient's corneal lesion area, i.e., the treatment area.

2. The personalized corneal cross-linking system according to claim 1, characterized in that: The personalized cross-linking scheme selection module also includes providing a honeycomb pattern or a bird's nest pattern for selection, using the selected pattern as the basis of the personalized cross-linking scheme, and combining the information collected by the information collection module to generate the personalized cross-linking pattern.

3. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The multi-level corneal cross-linking personalized customization module is also used to generate a personalized treatment enhancement plan, which is obtained by processing the anterior corneal surface curvature topography map and the posterior corneal surface curvature topography map in the corneal topography quadruple map. The personalized treatment enhancement plan includes areas where the corneal curvature is too large in local locations and needs to be treated intensively.

4. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The selectable personalized cross-linking schemes specifically include: a cross-linking treatment method that is personalized only with the cross-linking pattern, a cross-linking treatment method that is dual-personalized with the cross-linking pattern and the cross-linking energy, and a fully personalized cross-linking treatment method. The cross-linking treatment method that is personalized only with the cross-linking pattern is a cross-linking treatment method that only uses the generated personalized cross-linking pattern, the cross-linking treatment method that is dual-personalized with the cross-linking pattern and the cross-linking energy is a method that uses the sum of the generated cross-linking energy distribution map and the personalized cross-linking pattern, and the fully personalized cross-linking treatment method is a method that uses the sum of the generated cross-linking energy distribution map, the personalized cross-linking pattern, and the treatment enhancement personalized plan.

5. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The eye clock position calibration module automatically identifies the rotation angle of the eyeball in the plane during the operation according to the preoperative and intraoperative eye clock position information collected by the information collection module, and controls the personalized cross-linking image to rotate to the same angle.

6. The personalized corneal cross-linking system according to claim 5, characterized in that: Feature points are set for the image of the eyeball when the patient is in a normal position, and the eyeball clock position calibration module captures the corresponding feature points in real time during the intraoperative treatment position, calculates the corresponding clock position angle, and controls the generated personalized cross-linking pattern to rotate to a corresponding angle to adapt to the rotation of the eyeball.

7. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The eyeball clock position calibration module controls the personalized cross-linking image to rotate to a corresponding angle according to the eyeball clock position rotation information input by the user.

8. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The information acquisition module performs real-time pupil tracking, and determines the rotation angle of the eyeball in a plane through real-time pupil rotation measurement, which serves as a basis for the eyeball clock position calibration module to perform eyeball clock position calibration.

9. The personalized corneal cross-linking system according to any one of claims 1 to 2, characterized in that: The corneal OCT detection data includes anterior segment OCT detection data.

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