Implantable stimulators and stimulation systems

Abstract

The present application provides an implantable stimulator and a stimulation system, the implantable stimulator is arranged in the patient's body, and the implantable stimulator includes a first stimulation generation module to an Nth stimulation generation module, a first stimulation transmission module to an Mth stimulation transmission module, and a first stimulation release module to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; the i-th stimulation generation module is used to generate an electrical stimulation with an i-th stimulation parameter combination; the j-th stimulation release module is used to be close to the position of the j-th release position group in the patient's skull, connected to the k-th stimulation generation module, receive the k-th electrical stimulation and release the energy corresponding to the k-th electrical stimulation to the position of the j-th release position group, j is each positive integer not greater than M, and k is any positive integer not greater than N. The present application solves the problem that a patient needs to implant multiple stimulators to meet multiple stimulation needs by performing at least two types of stimulation at the same time with the same stimulator.

Description

Technical Field

[0001] The present application relates to the technical field of implantable medical devices, and in particular to an implantable stimulator and a stimulation system. Background Art

[0002] Among implantable medical devices, stimulators can effectively control the symptoms of functional and mental illnesses by providing chronic electrical stimulation to patients. Therefore, the treatment method of implanted stimulators can be applied to the treatment of a variety of diseases.

[0003] Existing implantable stimulators often implant the same electrode in patients. However, some patients may suffer from multiple diseases that require stimulation treatment, or the same patient may have different nuclei (or brain tissues) of the same disease that require different degrees of stimulation treatment, which requires multiple stimulators to be implanted in the patient's body, increasing the patient's financial burden and the pain of having multiple stimulators implanted in the body. Summary of the invention

[0004] The purpose of the present application is to provide an implantable stimulator and a stimulation system, which can simultaneously perform at least two types of stimulation by the same stimulator, thereby solving the problem that patients need to implant multiple stimulators to meet multiple stimulation needs.

[0005] The purpose of this application is achieved by the following technical solutions:

[0006] In a first aspect, the present application provides an implantable stimulator, which is arranged in a patient's body, and includes a first stimulation generation module to an Nth stimulation generation module, a first stimulation transmission module to an Mth stimulation transmission module, and a first stimulation release module to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; the i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; the j-th stimulation release module is used to approach one or more positions of the j-th release position group in the patient's skull, and the j-th stimulation release module is used to be connected to the k-th stimulation generation module through the j-th stimulation transmission module, receive the k-th electrical stimulation and release the energy corresponding to the k-th electrical stimulation to one or more positions of the j-th release position group, the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N.

[0007] The beneficial effect of this technical solution is that for patients with multiple diseases that require electrical stimulation treatment, at least two types of stimulation can be performed on the patient at the same time through the same implantable stimulator, reducing the economic burden on the patient and alleviating the pain of having multiple stimulators implanted in the patient's body. In addition, the same implantable stimulator can assist doctors in executing different stimulation instructions for different diseases or symptoms at the same time, and doctors have more treatment options based on the patient's condition.

[0008] In some optional embodiments, the i-th stimulation generation module is used to receive a program-controlled instruction sent by a program-controlled device, and determine the i-th stimulation parameter combination based on the program-controlled instruction. The beneficial effect of this technical solution is that when a doctor treats a patient who needs multiple electrical stimulation treatments, he can configure the stimulation parameters required for the treatment through the program-controlled device and implement different stimulation treatment plans.

[0009] In some optional embodiments, N=2, M=4; the first stimulation release module is used to connect to the first stimulation generation module through the first stimulation transmission module; the second stimulation release module is used to connect to the first stimulation generation module through the second stimulation transmission module; the third stimulation release module is used to connect to the second stimulation generation module through the third stimulation transmission module; the fourth stimulation release module is used to connect to the second stimulation generation module through the fourth stimulation transmission module. The beneficial effect of this technical solution is that it can meet the doctor's requirements for electrical stimulation treatment of two nuclei (or brain tissues) according to the patient's needs.

[0010] In some optional embodiments, the first stimulation release module is used for one or more positions of the first release position group near the left brain of the patient; the second stimulation release module is used for one or more positions of the second release position group near the right brain of the patient; the third stimulation release module is used for one or more positions of the third release position group near the left brain of the patient; the fourth stimulation release module is used for one or more positions of the fourth release position group near the right brain of the patient. The beneficial effect of this technical solution is that it can meet the needs of doctors who need simultaneous and identical electrical stimulation treatment of the left and right brains of patients for many diseases.

[0011] In some optional embodiments, N=2, M=3; the first stimulus release module is used to connect to the first stimulus generation module through the first stimulus transmission module; the second stimulus release module is used to connect to the first stimulus generation module through the second stimulus transmission module; the third stimulus release module is used to connect to the second stimulus generation module through the third stimulus transmission module. The beneficial effect of this technical solution is that it can meet the situation where doctors only need to stimulate one nucleus (or brain tissue) for many diseases of patients.

[0012] In some optional embodiments, the implantable stimulator also includes the first EEG acquisition module to the Qth EEG acquisition module, the first EEG transmission module to the Qth EEG transmission module and an EEG receiving module, Q is a positive integer; the pth EEG acquisition module is used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module through the pth EEG transmission module, and the value of p is each positive integer not greater than Q. The beneficial effect of this technical solution is that doctors can selectively treat patients according to the collected EEG information and the diseases that require electrical stimulation treatment, which reduces the pain of patients and improves the effect of treatment.

[0013] In some optional embodiments, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module. The beneficial effect of this technical solution is that more accurate data feedback is obtained during the electrical stimulation treatment, which can assist doctors in making targeted adjustments to the electrical stimulation parameters of the implantable stimulator.

[0014] In a second aspect, the present application provides an implantable stimulator, which is arranged in a patient's body, and includes a first stimulation generation module to an Nth stimulation generation module and a first stimulation release module to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; the i-th stimulation generation module is used to be arranged in the patient's skull, and the i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; the j-th stimulation release module is used to be close to one or more positions of the j-th release position group in the patient's skull, and the j-th stimulation release module is used to be connected to the k-th stimulation generation module, receive the k-th electrical stimulation and release the energy corresponding to the k-th electrical stimulation to one or more positions of the j-th release position group, the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N.

[0015] In some optional embodiments, the i-th stimulation generating module is used to receive a program-controlled instruction sent by a program-controlled device, and determine the i-th stimulation parameter combination based on the program-controlled instruction.

[0016] In some optional embodiments, N=2, M=4; the first stimulation release module is used to connect to the first stimulation generation module; the second stimulation release module is used to connect to the first stimulation generation module; the third stimulation release module is used to connect to the second stimulation generation module; the fourth stimulation release module is used to connect to the second stimulation generation module.

[0017] In some optional embodiments, the first stimulation release module is used for one or more positions of the first release position group near the patient's left intracranial brain; the second stimulation release module is used for one or more positions of the second release position group near the patient's right intracranial brain; the third stimulation release module is used for one or more positions of the third release position group near the patient's left intracranial brain; and the fourth stimulation release module is used for one or more positions of the fourth release position group near the patient's right intracranial brain.

[0018] In some optional embodiments, N=2, M=3; the first stimulation release module is used to connect to the first stimulation generation module; the second stimulation release module is used to connect to the first stimulation generation module; the third stimulation release module is used to connect to the second stimulation generation module.

[0019] In some optional embodiments, the implantable stimulator also includes the first to Qth EEG acquisition modules and an EEG receiving module, where Q is a positive integer; the pth EEG acquisition module is used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module, and the value of p is each positive integer not greater than Q.

[0020] In some optional embodiments, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module.

[0021] In a third aspect, the present application provides a stimulation system, which includes an implantable stimulator as described in any one of the above items; the stimulation system also includes a programmable device, which is used to receive programmable configuration operations, generate programmable instructions and send them to the implantable stimulator.

[0022] In some optional embodiments, the programmable device includes a doctor device and a programmer; the doctor device is used to receive the programmable configuration operation, generate the programmable instruction and send it to the programmer; the programmer is used to send the programmable instruction to the implantable stimulator. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The present application is further described below in conjunction with the accompanying drawings and embodiments.

[0024] Figure 1 is a structural schematic diagram of an implantable stimulator provided in an embodiment of the present application;

[0025] Figure 2 is a schematic structural diagram of another implantable stimulator provided in an embodiment of the present application;

[0026] Figure 3 is a structural schematic diagram of another implantable stimulator provided in an embodiment of the present application;

[0027] Figure 4 is a structural schematic diagram of another implantable stimulator provided in an embodiment of the present application;

[0028] Figure 5 is a structural schematic diagram of another implantable stimulator provided in an embodiment of the present application;

[0029] Figure 6 is a structural schematic diagram of another implantable stimulator provided in an embodiment of the present application;

[0030] Figure 7 It is a partial structural schematic diagram of an implantable stimulator provided in an embodiment of the present application;

[0031] Figure 8 is a structural schematic diagram of another implantable stimulator provided in an embodiment of the present application;

[0032] Fig. 9 It is a structural schematic diagram of a stimulation system provided in an embodiment of the present application.

[0033] Illustration: 100, implantable stimulator; 200, programmable device; 110, stimulation generation module; 120, stimulation transmission module; 130, stimulation release module; 160, EEG receiving module; 111-115, first stimulation generation module to fifth stimulation generation module; 121-128, first stimulation transmission module to eighth stimulation transmission module; 131-138, first stimulation release module to eighth stimulation release module; 141-144, first EEG acquisition module to fourth EEG acquisition module; 151-154, first EEG transmission module to fourth EEG transmission module; 210, doctor's equipment; 220, programmable device. DETAILED DESCRIPTION

[0034] Below, the present application is further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0035] The terms "first", "second", "third", "fourth", etc. (if any) in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein, for example. In addition, the terms "including" and "corresponding to" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0036] See also Figures 1 to 6 Embodiment 1 provides an implantable stimulator 100, which is arranged in the patient's body, and includes a first stimulation generation module 111 to an Nth stimulation generation module, a first stimulation transmission module 121 to an Mth stimulation transmission module, and a first stimulation release module 131 to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; the i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; the j-th stimulation release module is used to approach one or more positions of the j-th release position group in the patient's skull, and the j-th stimulation release module is used to be connected to the k-th stimulation generation module through the j-th stimulation transmission module, receive the k-th electrical stimulation and release the energy corresponding to the k-th electrical stimulation to one or more positions of the j-th release position group, the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N.

[0037] In the embodiment of the present application, each stimulus release module corresponds to a stimulus transmission module, and each stimulus release module is connected to one of the stimulus generation modules via a stimulus release module. Each stimulus generation module may correspond to 0, 1 or more stimulus release modules.

[0038] Each release position group may include one or more positions, such as 2, 3, 4, 6, 8, 12, etc.

[0039] The implantable stimulator 100 may be any one of an implantable neural electrical stimulation device, an implantable cardiac electrical stimulation system (also known as a pacemaker), an implantable drug delivery system (IDDS) and a lead switching device. Examples of implantable neural electrical stimulation devices include a deep brain stimulation system (DBS), an implantable cortical nerve stimulation system (CNS), an implantable spinal cord stimulation system (SCS), an implantable sacral nerve stimulation system (SNS), an implantable vagus nerve stimulation system (VNS), and the like. Stimulator parameters include frequency (the number of pulses per unit time 1s, in Hz), pulse width (duration of each pulse, in μs) and amplitude (generally expressed in voltage, i.e., the intensity of each pulse, in V). In specific applications, the various parameters of the stimulator can be adjusted in current mode or voltage mode. The stimulation transmission module 120 can be a module such as a filamentary wire or a ribbon wire that can realize electrical stimulation transmission; the stimulation release module 130 can be a single electrode or an electrode group composed of multiple electrodes. Doctors can use the implantable stimulator 100 to stimulate and treat different brain tissue locations corresponding to diseases or symptoms such as Parkinson's tremor, Parkinson's abdominal pain, obsessive-compulsive disorder, and depression. The embodiment of the present application does not limit the number of stimulator parameters configured by the doctor in one configuration operation. The doctor can configure one or more stimulator parameters at one time.

[0040] To achieve the purpose of stimulating different brain tissue locations, the ratio of the stimulation generation module 110 and the stimulation release module 130 acting on the patient for stimulation therapy may include but is not limited to 2:2, 2:3, 2:4, 3:6, 5:8.

[0041] In a specific implementation, N is, for example, 2, 3, or 4. When N=2, M is, for example, 2, 3, 4, or 5. When N=3, M is, for example, 3, 4, 5, or 6. When N=4, M is, for example, 4, 5, 6, 7, 8, or 9.

[0042] See also Figure 4In a specific application scenario, N=3, M=5. At this time, the values ​​of i are 1, 2, 3, respectively, the values ​​of j are 1, 2, 3, 4, 5, respectively, and the values ​​of k can be, for example, 1, 2, 3. The doctor performs electrical stimulation treatment on patient A who needs treatment for depression, obsessive-compulsive disorder and bipolar disorder at the same time, and implants an implantable stimulator 100 in the body of patient A. The implantable stimulator 100 includes three stimulation generation modules, five stimulation transmission modules and five stimulation release modules.

[0043] The first stimulation generating module 111 is used to generate an electrical stimulation with a voltage of 1.5 V, a frequency of 110 Hz, and a pulse width of 70 μs, which is recorded as the first electrical stimulation and is used to treat depression of patient A.

[0044] The second stimulation generating module 112 is used to generate an electrical stimulation with a voltage of 1.8 V, a frequency of 90 Hz, and a pulse width of 95 μs, which is recorded as the second electrical stimulation and is used to treat the obsessive-compulsive disorder of patient A.

[0045] The third stimulation generating module 113 is used to generate an electrical stimulation with a voltage of 1.8 V, a frequency of 120 Hz, and a pulse width of 80 μs, which is recorded as the third electrical stimulation and is used to treat the patient's bipolar disorder.

[0046] The first stimulation release module 131 is used to be close to one or more positions of the first release position group in the patient's skull. The first stimulation release module 131 is used to be connected to the first stimulation generation module 111 through the first stimulation transmission module 121, receive the first electrical stimulation and release the energy corresponding to the first electrical stimulation to one or more positions of the first release position group.

[0047] The second stimulation release module 132 is used to be close to one or more positions of the second release position group in the patient's skull. The second stimulation release module 132 is used to be connected to the first stimulation generation module 111 through the second stimulation transmission module 122, receive the first electrical stimulation and release the energy corresponding to the first electrical stimulation to one or more positions of the second release position group.

[0048] The third stimulation release module 133 is used to be close to one or more positions of the third release position group in the patient's skull. The third stimulation release module 133 is used to be connected to the second stimulation generation module 112 through the third stimulation transmission module 123, receive the second electrical stimulation and release the energy corresponding to the second electrical stimulation to one or more positions of the third release position group.

[0049] The fourth stimulation release module 134 is used to be close to one or more positions of the fourth release position group in the patient's skull. The fourth stimulation release module 134 is used to be connected to the third stimulation generation module 113 through the fourth stimulation transmission module 124, receive the third electrical stimulation and release the energy corresponding to the third electrical stimulation to one or more positions of the fourth release position group.

[0050] The fifth stimulation release module 135 is used to be close to one or more positions of the fifth release position group in the patient's skull. The fifth stimulation release module 135 is used to be connected to the third stimulation generation module 115 through the fifth stimulation transmission module 125, receive the fifth electrical stimulation and release the energy corresponding to the third electrical stimulation to one or more positions of the fifth release position group.

[0051] Therefore, doctors can use a single implantable stimulator 100 to simultaneously treat depression, obsessive-compulsive disorder, and bipolar disorder in patients.

[0052] Thus, for patients with multiple diseases that require electrical stimulation treatment, at least two types of stimulation can be performed on the patient at the same time through the same implantable stimulator 100, which greatly reduces the economic burden on the patient and alleviates the pain of implanting multiple stimulators in the patient's body. The same implantable stimulator 100 can assist doctors in executing different stimulation instructions for different diseases or symptoms at the same time, giving doctors more treatment options according to the patient's condition.

[0053] In some embodiments, the i-th stimulation generation module can be used to receive the program control instructions sent by the program control device 200, and determine the i-th stimulation parameter combination based on the program control instructions. Wherein, the program control device 200 includes at least one of the following: an in vitro program controller, an in vitro program controller, a tablet computer, a laptop computer, a desktop computer, a mobile phone, and an intelligent wearable device. In an embodiment of the present application, the program control device 200 is used to receive the doctor's configuration operation on the stimulator parameters, and the program control information can be the identification and parameter value of one or more stimulator parameters corresponding to the configuration operation. The in vitro program controller is, for example, the in vitro program controller disclosed in patent CN105709336B, or the implantable neural stimulator program controller disclosed in patent CN207412517U. The in vitro program controller is, for example, a program controller in an implantable neural electrical pulse stimulation system disclosed in patent CN100469401C, or a doctor program controller with security and confidentiality functions disclosed in patent CN201894778U.

[0054] Each stimulation parameter combination in the embodiments of the present application may include the identifier and parameter value of one or more stimulation parameters. The stimulation parameters may include at least one of the following: voltage, current, frequency, and pulse width. In a specific application scenario, a stimulation parameter combination is, for example, the voltage is 1.0V; the frequency is 90Hz. In another specific application scenario, a stimulation parameter combination is, for example, the voltage is 1.1V; the frequency is 110Hz; the pulse width is 80μs.

[0055] At this time, the i-th stimulation parameter combination can be different combinations of current or voltage amplitude, and pulse rate and pulse width in the case of stimulation pulses. Therefore, when a doctor treats a patient who needs multiple electrical stimulation treatments, he can configure the stimulation parameters required for the treatment through the program-controlled device 200 and implement different stimulation treatment plans.

[0056] See also Figure 2 In some implementations, N=2, M=4. At this time, the values ​​of i are 1 and 2, the values ​​of j are 1, 2, 3, and 4, and the values ​​of k can be 1 and 2, for example.

[0057] The first stimulus releasing module 131 is used to be connected to the first stimulus generating module 111 through the first stimulus transmitting module 121;

[0058] The second stimulus releasing module 132 is used to be connected to the first stimulus generating module 111 through the second stimulus transmitting module 122;

[0059] The third stimulus releasing module 133 is used to be connected to the second stimulus generating module 112 via the third stimulus transmitting module 123;

[0060] The fourth stimulus releasing module 134 is configured to be connected to the second stimulus generating module 112 via the fourth stimulus transmitting module 124 .

[0061] In a specific application scenario, a doctor treats a patient B who suffers from depression and Parkinson's disease. It is necessary to electrically stimulate two nuclei related to the treatment of depression and two nuclei related to the treatment of Parkinson's disease. The first stimulation generation module 111 of the implantable stimulator 100 in the patient's body is used to receive the treatment instruction for Parkinson's disease sent by the program-controlled device 200 to generate the first electrical stimulation and transmit it to the first stimulation release module 131 and the third stimulation release module 133. The second stimulation generation module 112 is used to receive the treatment instruction for depression sent by the program-controlled device 200 to generate the second electrical stimulation and transmit it to the second stimulation release module 132 and the fourth stimulation release module 134, so as to achieve the treatment of Parkinson's disease and depression for the patient B at the same time. In this way, the doctor's requirement for stimulation treatment of two nuclei (or brain tissues) according to the patient's needs can be met.

[0062] In some embodiments, the first stimulation release module 131 can be used for one or more positions of the first release position group near the patient's left intracranial brain; the second stimulation release module 132 can be used for one or more positions of the second release position group near the patient's right intracranial brain; the third stimulation release module 133 can be used for one or more positions of the third release position group near the patient's left intracranial brain; the fourth stimulation release module 134 can be used for one or more positions of the fourth release position group near the patient's right intracranial brain.

[0063] In a specific application scenario, a doctor treats a patient who suffers from both depression and Parkinson's disease. The doctor needs to perform electrical stimulation of 1.1V voltage, 110Hz frequency and 90μs pulse width on two nuclei related to Parkinson's disease in the left and right brain of the patient to treat Parkinson's disease, and perform electrical stimulation of 1.3V voltage and 90Hz frequency on two nuclei related to depression in the left and right brain of the patient. In this way, the doctor's needs for simultaneous and identical electrical stimulation of the left and right brains of patients with many diseases can be met.

[0064] See also Figure 3 In some embodiments, N=2, M=3; in this case, the values ​​of i are 1 and 2, the values ​​of j are 1, 2, and 3, and the values ​​of k can be, for example, 1 and 2. The first stimulus releasing module 131 can be used to connect to the first stimulus generating module 111 through the first stimulus transmitting module 121; the second stimulus releasing module 132 can be used to connect to the first stimulus generating module 111 through the second stimulus transmitting module 122; the third stimulus releasing module 133 can be used to connect to the second stimulus generating module 112 through the third stimulus transmitting module 123.

[0065] In a specific application scenario, a doctor treats a patient with obsessive-compulsive disorder and Parkinson's disease. According to the diagnostic information, the doctor needs to perform electrical stimulation of two nuclei related to the treatment of Parkinson's disease in the left and right brains of the patient with a voltage of 1.1V, a frequency of 110Hz, and a pulse width of 90μs to treat Parkinson's disease; and perform electrical stimulation of a nucleus related to the treatment of obsessive-compulsive disorder in the left brain of the patient with a voltage of 1.3V and a frequency of 90Hz to treat obsessive-compulsive disorder. In this way, the doctor's needs for simultaneous and identical electrical stimulation of the left and right brains of patients with many diseases can be met. In this way, the doctor's needs for treating patients with many diseases who only need to stimulate one nucleus (or brain tissue) can be met.

[0066] In some embodiments, the implantable stimulator 100 may also include a first EEG acquisition module 141 to a Qth EEG acquisition module, a first EEG transmission module 151 to a Qth EEG transmission module and an EEG receiving module 160, where Q is a positive integer; the pth EEG acquisition module can be used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module 160 through the pth EEG transmission module, and the value of p is each positive integer not greater than Q.

[0067] See also Figure 7 In a specific application scenario, Q=4, and the values ​​of p are 1, 2, 3, and 4 respectively. The EEG information collected by the first EEG acquisition module 141 in the first acquisition position group is sent to the EEG receiving module 160 through the first EEG transmission module 151; the EEG information collected by the first EEG acquisition module 142 in the first acquisition position group is sent to the EEG receiving module 160 through the first EEG transmission module 152; the EEG information collected by the first EEG acquisition module 143 in the first acquisition position group is sent to the EEG receiving module 160 through the first EEG transmission module 153; the EEG information collected by the first EEG acquisition module 144 in the first acquisition position group is sent to the EEG receiving module 160 through the first EEG transmission module 154.

[0068] The doctor treats patients with Parkinson's disease and obsessive-compulsive disorder. The doctor can judge that the first acquisition position group and the second acquisition position group are suitable for treatment according to the treatment plan for Parkinson's disease, and the third acquisition position group and the fourth acquisition position group are suitable for treatment according to the treatment plan for obsessive-compulsive disorder based on the received EEG information. The doctor performs electrical stimulation treatment for Parkinson's disease in the first acquisition position group and the second acquisition position group, and performs electrical stimulation treatment for obsessive-compulsive disorder in the third acquisition position group and the fourth acquisition position group based on the judgment result of the patient's condition and the EEG information collected by the EEG acquisition module. Thus, the doctor can selectively perform treatment based on the collected EEG information and the disease that the patient needs electrical stimulation treatment for, thereby alleviating the patient's pain and improving the effect of treatment.

[0069] In some embodiments, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module. The EEG signals of the brain area acted upon by each stimulation release module can be mastered by the doctor, and the doctor can provide targeted treatment to the patient based on the mastered EEG signals. Thus, more accurate data feedback can be obtained during the stimulation treatment process, which can assist the doctor in making targeted adjustments to the electrical stimulation parameters of the implantable stimulator 100.

[0070] In a specific implementation, the stimulation release module 130 and the EEG acquisition module can be integrated into one. The stimulation release module 130 can be a macroelectrode with a larger size, and the EEG acquisition module can be a microelectrode with a smaller size. The microelectrode can be arranged inside (at a central position or a non-central position) or around the macroelectrode. Figure 1 In some implementations, N=2, M=2. At this time, the values ​​of i are 1 and 2, the values ​​of j are 1 and 2, and the values ​​of k can be 1 and 2, for example.

[0071] The first stimulus releasing module 131 is used to be connected to the first stimulus generating module 111 through the first stimulus transmitting module 121 .

[0072] The second stimulus releasing module 132 is used to be connected to the second stimulus generating module 112 through the second stimulus transmitting module 122 .

[0073] See also Figure 5 In some implementations, N=5, M=8. At this time, the values ​​of i are 1, 2, 3, 4, 5, respectively, the values ​​of j are 1, 2, 3, 4, 5, 6, 7, 8, respectively, and the values ​​of k can be, for example, 1, 2, 3, 4.

[0074] The first stimulus releasing module 131 is used to be connected to the first stimulus generating module 111 through the first stimulus transmitting module 121 .

[0075] The second stimulus releasing module 132 is used to be connected to the second stimulus generating module 112 through the second stimulus transmitting module 122 .

[0076] The third stimulus releasing module 133 is used to be connected to the second stimulus generating module 112 through the third stimulus transmitting module 123 .

[0077] The fourth stimulus releasing module 134 is used to be connected to the third stimulus generating module 113 via the fourth stimulus transmitting module 124 .

[0078] The fifth stimulus releasing module 135 is used to be connected to the third stimulus generating module 113 via the fifth stimulus transmitting module 125 .

[0079] The sixth stimulus releasing module 136 is configured to be connected to the fourth stimulus generating module 114 via the sixth stimulus transmitting module 126 .

[0080] The seventh stimulus releasing module 137 is used to be connected to the fourth stimulus generating module 114 via the seventh stimulus transmitting module 127 .

[0081] The eighth stimulus releasing module 138 is configured to be connected to the fifth stimulus generating module 115 via the eighth stimulus transmitting module 128 .

[0082] See also Figure 8 Embodiment 2 provides an implantable stimulator 100, which is arranged in the patient's body, and the implantable stimulator 100 includes a first stimulation generation module 111 to an Nth stimulation generation module and a first stimulation release module 131 to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; the i-th stimulation generation module is used to be arranged in the patient's skull, and the i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; the j-th stimulation release module is used to approach one or more positions of the j-th release position group in the patient's skull, and the j-th stimulation release module is used to connect to the k-th stimulation generation module, receive the k-th electrical stimulation and release the energy corresponding to the k-th electrical stimulation to one or more positions of the j-th release position group, and the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N.

[0083] Figure 8 An implantable stimulator 100 is shown with N=3, M=6.

[0084] In some implementations, the i-th stimulation generating module may be configured to receive a program control instruction sent by the program control device 200, and determine the i-th stimulation parameter combination based on the program control instruction.

[0085] In some embodiments, N=2, M=4; the first stimulus release module 131 can be connected to the first stimulus generation module 111; the second stimulus release module 132 can be connected to the first stimulus generation module 111; the third stimulus release module 133 can be connected to the second stimulus generation module 112; the fourth stimulus release module 134 can be connected to the second stimulus generation module 112.

[0086] In some embodiments, the first stimulation release module 131 can be used for one or more positions of the first release position group near the patient's left intracranial brain; the second stimulation release module 132 can be used for one or more positions of the second release position group near the patient's right intracranial brain; the third stimulation release module 133 can be used for one or more positions of the third release position group near the patient's left intracranial brain; the fourth stimulation release module 134 can be used for one or more positions of the fourth release position group near the patient's right intracranial brain.

[0087] In some embodiments, N=2, M=3; the first stimulus releasing module 131 can be connected to the first stimulus generating module 111; the second stimulus releasing module 132 can be connected to the first stimulus generating module 111; the third stimulus releasing module 133 can be connected to the second stimulus generating module 112.

[0088] In some embodiments, the implantable stimulator 100 may also include a first EEG acquisition module 141 to a Qth EEG acquisition module and an EEG receiving module 160, where Q is a positive integer; the pth EEG acquisition module is used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module 160, and the value of p is each positive integer not greater than Q.

[0089] In some embodiments, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module.

[0090] See also Fig. 9 Embodiment 3 provides a stimulation system, which includes the implantable stimulator 100 described in any one of the above items; the stimulation system also includes a program-controlled device 200, which is used to receive program-controlled configuration operations, generate program-controlled instructions and send them to the implantable stimulator 100.

[0091] In some embodiments, the program-controlled device 200 may include a doctor device 210 and a programmer 220; the doctor device 210 is used to receive the program-controlled configuration operation, generate the program-controlled instruction and send it to the programmer 220; the programmer 220 is used to send the program-controlled instruction to the implantable stimulator 100. The doctor device 210 is, for example, a mobile phone, a tablet computer, a computer, a smart wearable device or other smart terminal device, and the doctor device 210 may run an app for configuring stimulator parameters, and a plurality of function buttons may be set in the app, and these function buttons are used to receive control operations to change the parameter configuration interface, thereby changing the stimulation parameters.

[0092] The control operation may include at least one of the following: start, pause, continue, stop, reset and gesture operation. The gesture operation may include contact gesture operation and / or air gesture operation.

[0093] The contact gesture operation may include, for example, at least one of the following: a contact gesture swiping upward; a contact gesture swiping downward; a short press; a long press; a contact gesture sliding inward from the (top, bottom, left or right) edge.

[0094] The air gesture operation may, for example, include at least one of the following: an air grab gesture; an air gesture swipe to the left, an air gesture swipe to the right, an air gesture swipe up, and an air gesture swipe down.

[0095] For example, when the contact gesture operation is a contact gesture of swiping upwards, the parameter value of the selected configuration parameter in the parameter configuration interface is increased; when the contact gesture operation is a contact gesture of swiping downwards, it returns to the previous operation; when the air gesture operation is a grabbing gesture, the current configuration parameters are saved; when the air gesture operation is a short press, the configuration page is opened.

[0096] Therefore, when doctors treat patients who need multiple electrical stimulation treatments, they only need one implantable stimulator to receive programming instructions, and can configure the stimulation parameters required for the treatment through the programmable device 200 to implement different stimulation treatment plans.

[0097] This application is explained from the perspectives of purpose of use, effectiveness, progress and novelty, and has met the functional enhancement and usage requirements emphasized by the Patent Law. The above description and drawings of this application are only the preferred embodiments of this application, and are not intended to limit this application. Therefore, all structures, devices, features, etc. that are similar or identical to this application, that is, all equivalent replacements or modifications made in accordance with the scope of the patent application of this application, should fall within the scope of protection of the patent application of this application.

Claims

1. An implantable stimulator, characterized in that: The implantable stimulator is disposed in the patient's body, and includes a first stimulation generation module to an Nth stimulation generation module, a first stimulation transmission module to an Mth stimulation transmission module, and a first stimulation release module to an Mth stimulation release module, N is a positive integer greater than 1, and M is a positive integer not less than N; The i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, which is recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; The jth stimulation release module is used to be close to one or more positions of the jth release position group in the patient's skull, and the jth stimulation release module is used to be connected to the kth stimulation generation module through the jth stimulation transmission module, receive the kth electrical stimulation and release the energy corresponding to the kth electrical stimulation to one or more positions of the jth release position group, the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N; Each stimulus release module corresponds to a stimulus transmission module, each stimulus release module is connected to one of the stimulus generation modules via a stimulus release module, and each stimulus generation module can correspond to 0, 1 or more stimulus release modules; The implantable stimulator also includes a first EEG acquisition module to a Qth EEG acquisition module, a first EEG transmission module to a Qth EEG transmission module and an EEG receiving module, where Q is a positive integer; The pth EEG acquisition module is used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module through the pth EEG transmission module, and the value of p is each positive integer not greater than Q; Wherein, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module; The implantable stimulator stimulates and treats different brain tissue locations corresponding to Parkinson's hand tremor, Parkinson's abdominal pain, obsessive-compulsive disorder, and depression.

2. The implantable stimulator according to claim 1, characterized in that The i-th stimulation generating module is used to receive a program control instruction sent by a program control device, and determine the i-th stimulation parameter combination based on the program control instruction.

3. The implantable stimulator according to claim 1, characterized in that N=2, M=4; The first stimulus releasing module is used to be connected to the first stimulus generating module via the first stimulus transmitting module; The second stimulus releasing module is used to be connected to the first stimulus generating module via the second stimulus transmitting module; The third stimulus releasing module is used to be connected to the second stimulus generating module via the third stimulus transmitting module; The fourth stimulus releasing module is used to be connected to the second stimulus generating module via the fourth stimulus transmitting module.

4. The implantable stimulator according to claim 3, characterized in that The first stimulation release module is used to be close to one or more positions of a first release position group of the left brain of the patient; The second stimulation release module is used to be close to one or more positions of a second release position group of the right brain of the patient; The third stimulation release module is used to be close to one or more positions of a third release position group of the left brain of the patient; The fourth stimulation release module is used to be close to one or more positions of a fourth release position group of the patient's intracranial right brain.

5. The implantable stimulator according to claim 1, characterized in that N=2, M=3; The first stimulus releasing module is used to be connected to the first stimulus generating module via the first stimulus transmitting module; The second stimulus releasing module is used to be connected to the first stimulus generating module via the second stimulus transmitting module; The third stimulus releasing module is used to be connected to the second stimulus generating module through the third stimulus transmitting module.

6. An implantable stimulator, characterized in that: The implantable stimulator is disposed in the patient's body, and includes a first stimulation generation module to an Nth stimulation generation module and a first stimulation release module to an Mth stimulation release module, where N is a positive integer greater than 1, and M is a positive integer not less than N; The i-th stimulation generation module is used to be arranged in the patient's skull, and the i-th stimulation generation module is used to generate an electrical stimulation having an i-th stimulation parameter combination, which is recorded as the i-th electrical stimulation, and the value of i is each positive integer not greater than N; The jth stimulation release module is used to be close to one or more positions of the jth release position group in the patient's skull, and the jth stimulation release module is used to be connected to the kth stimulation generation module, receive the kth electrical stimulation and release the energy corresponding to the kth electrical stimulation to one or more positions of the jth release position group, the value of j is each positive integer not greater than M, and the value of k is any positive integer not greater than N; Each stimulus release module corresponds to a stimulus transmission module, each stimulus release module is connected to one of the stimulus generation modules via a stimulus release module, and each stimulus generation module can correspond to 0, 1 or more stimulus release modules; The implantable stimulator also includes a first EEG acquisition module to a Qth EEG acquisition module, a first EEG transmission module to a Qth EEG transmission module and an EEG receiving module, where Q is a positive integer; The pth EEG acquisition module is used to collect EEG information of one or more positions of the pth acquisition position group, recorded as the pth EEG information, and send the pth EEG information to the EEG receiving module through the pth EEG transmission module, and the value of p is each positive integer not greater than Q; Wherein, Q=M, the i-th EEG acquisition module is close to the i-th stimulation release module, and the i-th EEG acquisition module is insulated from the i-th stimulation release module; The implantable stimulator stimulates and treats different brain tissue locations corresponding to Parkinson's hand tremor, Parkinson's abdominal pain, obsessive-compulsive disorder, and depression.

7. A stimulation system, characterized in that: The stimulation system comprises the implantable stimulator according to any one of claims 1 to 5 or the implantable stimulator according to claim 6; The stimulation system also includes a program-controlled device, which is used to receive program-controlled configuration operations, generate program-controlled instructions, and send them to the implantable stimulator.

8. The stimulation system according to claim 7, characterized in that The program-controlled device includes a doctor's device and a programmer; The doctor device is used to receive the program control configuration operation, generate the program control instruction and send it to the programmer; The programmer is used to send the programming instructions to the implantable stimulator.

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