Additive composition and use of pyruvic acid or pyruvic acid salt

Abstract

An additive composition and use of pyruvic acid or pyruvic acid salt. The present specification relates to an additive composition for preventing oxidation of vitamin C or vitamin C derivatives in a cosmetic composition containing vitamin C or vitamin C derivatives. The additive composition disclosed herein contains pyruvic acid or pyruvic acid salt as an active ingredient, thereby showing a higher effect of preventing oxidation of vitamin C or vitamin C derivatives even at a lower dosage than that of the oxidation prevention agent used in the past.

Description

Technical Field

[0001] The present invention provides an additive composition for preventing oxidation of vitamin C in a cosmetic composition containing vitamin C. Background Art

[0002] Vitamin C provides antioxidant effect to human body, improves immune function, and is mostly used as health food. It provides anti-aging and whitening effects to skin by promoting collagen generation and skin regeneration effect, and is also widely used as an effective ingredient of cosmetics. However, when vitamin C is exposed under external environments such as oxygen, light, heat, pH, it is easily oxidized and deteriorates. For this reason, glutathione is used as an antioxidant for preventing vitamin C from oxidizing, but glutathione is difficult to contain more than a certain content in a cosmetic composition because of its own peculiar smell. Therefore, it is required to develop a vitamin C antioxidant that can replace glutathione.

[0003] [Prior art literature]

[0004] [Patent Document]

[0005] (Patent Document 1) Korean Patent Publication No. 10-1815225 Summary of the invention

[0006] From one viewpoint, the problem to be solved by the invention disclosed in the present disclosure is to provide an additive composition for preventing oxidation of a composition containing vitamin C or a vitamin C derivative.

[0007] In order to solve the above problems, the present disclosure provides an additive composition for preventing oxidation of vitamin C or a vitamin C derivative in a cosmetic composition containing vitamin C or a vitamin C derivative, wherein the additive composition contains pyruvic acid or a pyruvate as an active ingredient.

[0008] The invention disclosed herein can prevent oxidation of vitamin C or vitamin C derivatives, and is useful as an additive for stabilizing vitamin C or vitamin C derivatives. The pyruvic acid or pyruvic acid salt contained in the invention disclosed herein can exhibit a higher effect of preventing oxidation of vitamin C or vitamin C derivatives even at a lower amount than that of the oxidation inhibitors used in the past. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 This is a graph comparing the antioxidant effects of sodium pyruvate as an example of the present disclosure, glutathione (GSH) as a comparative example, and glyoxylic acid, starting from the left.

[0010] Figure 2The figure shows a standard curve obtained by measuring the degree of oxidation of vitamin C over time.

[0011] Figure 3 The photographs are, starting from the left, comparing the antioxidant effects of vitamin C of sodium pyruvate as an embodiment of the present disclosure, glutathione (GSH) as a comparative example, and glyoxylic acid.

[0012] Figure 4 The graph is a comparison of the antioxidant effects of vitamin C of sodium pyruvate as an embodiment of the present disclosure, glutathione (GSH) as a comparative example, and glyoxylic acid (glyoxylic acid), starting from the left.

[0013] Figure 5 This is a photograph comparing the antioxidant effect of vitamin C based on the content of sodium pyruvate as an embodiment of the present disclosure.

[0014] Figure 6 This is a chart comparing the antioxidant effects of vitamin C based on the content of sodium pyruvate as an embodiment of the present disclosure.

[0015] Figure 7 This is a photograph comparing the antioxidant effects of vitamin C based on the types of pyruvate derivatives as one embodiment of the present disclosure.

[0016] Figure 8 This is a graph comparing the antioxidant effects of vitamin C based on the types of pyruvate derivatives as one embodiment of the present disclosure.

[0017] Fig. 9 This is a graph comparing the dosage form stability of compositions based on the content of sodium pyruvate as one embodiment of the present disclosure.

[0018] Fig.10 This is a photograph comparing the antioxidant effect of vitamin C based on the content of vitamin C and the content of sodium pyruvate as an example of the present disclosure.

[0019] Fig.11 This is a graph comparing the antioxidant effect of vitamin C based on the content of vitamin C and the content of sodium pyruvate as one embodiment of the present disclosure. DETAILED DESCRIPTION

[0020] Hereinafter, the embodiments of the present disclosure will be described in more detail with reference to the accompanying drawings. However, the technology disclosed in the present application is not limited to the embodiments described herein, and may also be embodied in other forms. The embodiments introduced herein are only provided to make the disclosed content thorough and complete, and to fully convey the idea of ​​the present application to those skilled in the art. As long as one has common knowledge in the art, the idea of ​​the present application may be embodied in other various forms without departing from the technical idea of ​​the present application.

[0021] One embodiment of the present disclosure provides an additive composition for preventing oxidation of vitamin C or a vitamin C derivative in a cosmetic composition containing vitamin C or a vitamin C derivative, wherein the additive composition contains pyruvic acid or pyruvate as an active ingredient.

[0022] An embodiment of the present disclosure provides a cosmetic composition, including: vitamin C or a vitamin C derivative; and the additive composition.

[0023] In the present disclosure, "vitamin C" is also referred to as ascorbic acid, and includes both natural vitamin C and synthetic vitamin C.

[0024] In the present disclosure, the ascorbic acid derivative refers to a compound that, when acting on the human body, is converted into vitamin C in the body. The ascorbic acid derivative included in the cosmetic composition of the present disclosure is not limited, but may specifically be a water-soluble ascorbic acid derivative. More specifically, the vitamin C derivative may include one or more selected from the group consisting of sodium ascorbyl phosphate (SAP), magnesium ascorbyl phosphate (MAP), calcium ascorbyl phosphate, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl stearate, ascorbyl glucoside and ascorbyl ethylsilanol pectinate.

[0025] In one embodiment, the vitamin C or vitamin C derivative not only has an antioxidant effect, but also protects the skin from ultraviolet rays, inhibits the activity of damaged tyrosinase, thereby preventing pigmentation and providing skin whitening effects. In addition, vitamin C can promote skin regeneration and improve skin wrinkles or elasticity by forming collagen.

[0026] In the present disclosure, the pyruvate may include one or more selected from the group consisting of sodium pyruvate, methyl pyruvate, and ethyl pyruvate.

[0027] In the present disclosure, one embodiment may provide a use of pyruvic acid or pyruvic acid salt, wherein the pyruvic acid or pyruvic acid salt is used as an effective ingredient to prepare an additive composition for preventing oxidation of vitamin C or vitamin C derivatives in a cosmetic composition containing vitamin C or vitamin C derivatives. In another embodiment, a method for preventing oxidation of vitamin C or vitamin C derivatives may be provided, comprising: adding pyruvic acid or pyruvic acid salt in an effective dose to a cosmetic composition containing vitamin C or vitamin C derivatives. In another embodiment, a pyruvic acid or pyruvic acid salt may be provided for preventing oxidation of vitamin C or vitamin C derivatives in a cosmetic composition containing vitamin C or vitamin C derivatives. In another embodiment, a pyruvic acid or pyruvic acid salt may be provided, wherein the pyruvic acid or pyruvic acid salt is used as an effective ingredient in an additive composition, wherein the additive composition is used to prevent oxidation of vitamin C or vitamin C derivatives in a cosmetic composition containing vitamin C or vitamin C derivatives.

[0028] In the present disclosure, as an embodiment, the pyruvic acid or pyruvic acid salt can be added in an amount of 0.001 wt % to 10 wt % relative to the total weight of the cosmetic composition. In the present disclosure, as an embodiment, the pyruvic acid or pyruvic acid salt can be added in an amount of 0.01 wt % to 1 wt % relative to the total weight of the cosmetic composition. Specifically, as an embodiment, the pyruvic acid or pyruvic acid salt can be added in an amount of 0.001 wt %, 0.01 wt %, 0.02 wt %, 0.03 wt %, 0.04 wt %, 0.05 wt %, 0.06 wt %, 0.07 wt %, 0.08 wt %, 0.09 wt %, 0.1 wt %, 0.2 wt %, 0.3 wt %, 0.4 wt %, 0.5 wt %, 0.6 wt %, 0.7 wt %, 0.8 wt %, 0.9 wt %, 1 wt %, 2 wt %, 3 wt %, 4 wt %, 5 wt %, 6 wt %, 7 wt %, 8 wt %, 9 wt %, or 9.99 wt % or more relative to the total weight of the cosmetic composition. In addition, as an embodiment, the pyruvic acid or pyruvic acid salt can be added in an amount of 10 wt % or less, 9 wt % or less, 8 wt % or less, 7 wt % or less, 6 wt % or less, 5 wt % or less, 4 wt % or less, 3 wt % or less, 2 wt % or less, 1 wt % or less, 0.99 wt % or less, 0.9 wt % or less, 0.8 wt % or less, 0.7 wt % or less, 0.6 wt % or less, 0.5 wt % or less, 0.4 wt % or less, 0.3 wt % or less, 0.2 wt % or less, 0.15 wt % or less, 0.1 wt % or less, 0.09 wt % or less, 0.08 wt % or less, 0.07 wt % or less, 0.06 wt % or less, 0.05 wt % or less, 0.04 wt % or less, 0.03 wt % or less, 0.02 wt % or less, or 0.01 wt % or less, relative to the total weight of the cosmetic composition. When the pyruvic acid or pyruvic acid salt is added in an amount exceeding 10% by weight relative to the total weight of the cosmetic composition, the dosage form stability of the cosmetic composition may be reduced, and when the amount is less than 0.001% by weight, the antioxidant effect of vitamin C or vitamin C derivatives may be insufficient.

[0029] In the present disclosure, the additive composition is added to a cosmetic composition containing vitamin C or a vitamin C derivative, thereby preventing oxidation of vitamin C or a vitamin C derivative even with a smaller amount of antioxidant than that used in the past. Therefore, the efficacy and quality of the cosmetic composition containing vitamin C or a vitamin C derivative can be maintained for a long time.

[0030] In the present disclosure, as an embodiment, the cosmetic composition may contain 1 to 30 wt% of vitamin C or a vitamin C derivative relative to the total weight of the cosmetic composition. Specifically, the cosmetic composition may contain 1 wt% or more, 2 wt% or more, 3 wt% or more, 4 wt% or more, 5 wt% or more, 6 wt% or more, 7 wt% or more, 8 wt% or more, 9 wt% or more, 10 wt% or more, 11 wt% or more, 12 wt% or more, 13 wt% or more, 14 wt% or more, 15 wt% or more, 16 wt% or more, 17 wt% or more, 18 wt% or more, 19 wt% or more, 20 wt% or more, 21 wt% or more, 22 wt% or more, 23 wt% or more, 24 wt% or more, 25 wt% or more, 26 wt% or more, 27 wt% or more, 28 wt% or more, or 29 wt% or more of vitamin C or a vitamin C derivative relative to the total weight of the cosmetic composition. In addition, as an embodiment, the cosmetic composition may contain 30% by weight or less, 29% by weight or less, 28% by weight or less, 27% by weight or less, 26% by weight or less, 25% by weight or less, 24% by weight or less, 23% by weight or less, 22% by weight or less, 21% by weight or less, 20% by weight or less, 19% by weight or less, 18% by weight or less, 17% by weight or less, 16% by weight or less, 15% by weight or less, 14% by weight or less, 13% by weight or less, 12% by weight or less, 11% by weight or less, 10% by weight or less, 9% by weight or less, 8% by weight or less, 7% by weight or less, 6% by weight or less, 5% by weight or less, 4% by weight or less, 3% by weight or less, 2% by weight or less, or 1% by weight of vitamin C or a vitamin C derivative, relative to the total weight of the cosmetic composition.

[0031] In the present disclosure, as an embodiment, the weight ratio of vitamin C or vitamin C derivatives to pyruvic acid or pyruvic acid salt contained in the cosmetic composition may be 5 to 30: 0.01 to 1. Specifically, as an embodiment, the weight ratio of vitamin C or vitamin C derivatives to pyruvic acid or pyruvic acid salt contained in the cosmetic composition may be 10 to 20: 0.01 to 1. Specifically, as an embodiment, the weight ratio of vitamin C or vitamin C derivatives to pyruvic acid or pyruvic acid salt contained in the cosmetic composition may be 10 to 20: 0.01 or more, 10 to 20: 0.05 or more, 10 to 20: 0.1 or more, 10 to 20: 0.2 or more, 10 to 20: 0.3 or more, 10 to 20: 0.4 or more, 10 to 20: 0.5 or more, 10 to 20: 0.6 or more, 10 to 2 The weight ratio of vitamin C or vitamin C derivatives can be 0:0.7 or more, 10 to 20:0.8 or more, or 10 to 20:0.9 or more, and can be 10 to 20:1 or less, 10 to 20:0.9 or less, 10 to 20:0.8 or less, 10 to 20:0.7 or less, 10 to 20:0.6 or less, 10 to 20:0.5 or less, 10 to 20:0.4 or less, 10 to 20:0.3 or less, 10 to 20:0.2 or less, or 10 to 20:0.1 or less. Within the weight ratio range, the antioxidant efficiency of vitamin C or vitamin C derivatives can be improved while the dosage form of the cosmetic composition becomes stable.

[0032] In the present disclosure, as an embodiment, the cosmetic composition can be used for skin anti-oxidation, skin whitening, improvement of skin wrinkles or improvement of skin elasticity. In the present disclosure, "skin" refers to the tissue covering the body surface of an animal, not only the tissue covering the body surface of the face or body, but also the broadest concept including scalp and hair.

[0033] In one embodiment of the present disclosure, the cosmetic composition may contain a cosmetically or dermatologically acceptable medium or matrix to form a dosage form. As all dosage forms suitable for topical use, it can be provided as: such as a solution, gel, solid, anhydrous paste, an emulsion obtained by dispersing an oil phase in an aqueous phase, a suspension, a microemulsion, a microcapsule, a microparticle ball, or an ionic (liposome) and non-ionic vesicle dispersion, or a cream, a lotion, an emulsion, a powder, an ointment, a spray or a concealer stick. In addition, it can also be used in the form of a foam or an aerosol composition further containing a compressed propellant. These compositions can be prepared by methods commonly used in the art.

[0034] In one embodiment of the present disclosure, the cosmetic composition and the active ingredient preferably contain other ingredients that produce synergistic effects on the main effect within the scope of not destroying the main effect. In addition to the active ingredients of the present invention, according to the dosage form or purpose of use of other cosmetic compositions, it is not difficult for those skilled in the art to select and prepare other ingredients. In addition, as an embodiment, the cosmetic composition of the present invention, together with the ingredients, may include other ingredients prepared in general cosmetic compositions as needed. For example, moisturizers, lubricants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH regulators, alcohol, pigments, spices, blood circulation promoters, cooling agents, antiperspirants, purified water, etc. can be cited. Other formulation ingredients that may be included in the cosmetic composition of the present invention are not limited thereto, and the formulation amount of the ingredients may be within the scope of not destroying the purpose and effect of the present invention.

[0035] In one embodiment of the present disclosure, the composition to which the additive composition is added may be a food composition. For example, it may be processed into functional foods such as fermented oil, cheese, yogurt, juice, probiotics and health foods containing the active ingredients, and in addition, it may be used as a variety of food additives. As one embodiment, the composition may be a composition for health food. As one embodiment, the composition for health food may be formulated into pills, capsules, tablets, granules, caramel or beverages, etc. As another embodiment, it may also be processed into forms such as liquids, powders, granules, tablets or tea bags. The composition may be administered by a variety of methods such as simple drinking, injection, spraying or extrusion. The cosmetic composition may contain other ingredients that produce synergistic effects on the main effects within the scope of not destroying the main effects. For example, in order to improve the physical properties, additives such as spices, pigments, bactericides, antioxidants, preservatives, moisturizers, thickeners, inorganic dyes, emulsifiers and synthetic polymers may also be included. In addition, auxiliary ingredients such as water-soluble vitamins, fat-soluble vitamins, polymer peptides, polymer polysaccharides and seaweed extracts may also be included. The components can be appropriately selected and formulated by those skilled in the art according to the dosage form or the purpose of use, and the amount thereof can be selected within the range that does not damage the purpose and effect of the present invention. For example, the amount of the components added can be 0.0001 wt % to 99.9 wt % based on the total weight of the composition.

[0036] In one embodiment of the present disclosure, the composition to which the additive composition is added may be a pharmaceutical composition. The pharmaceutical composition may further contain pharmaceutical adjuvants such as preservatives, stabilizers, wettable powders or emulsifiers, salts for regulating osmotic pressure and / or buffers, and other therapeutically useful substances.

[0037] As an embodiment, the pharmaceutical composition can be an oral dosage form, and the oral dosage form includes, for example, tablets, pills, hard capsules or soft capsules, liquids, suspensions, emulsifiers, syrups, powders, granules, granules, micropills, etc. In addition to the active ingredients, these dosage forms can contain surfactants, diluents (for example, lactose, glucose, sucrose, mannitol, sorbitol, cellulose or glycine), lubricants (for example, silicon dioxide, talc, stearic acid and its magnesium or calcium salts and polyethylene glycol). Tablets can also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth gum, methylcellulose, sodium carboxymethylcellulose and polyvinyl pyrrolidone. Depending on the circumstances, pharmaceutical additives such as disintegrants, absorbents, colorants, flavoring agents and sweeteners such as starch, agar, alginic acid or its sodium salt can be contained. The tablets can be prepared by conventional mixing, granulation or coating methods.

[0038] As an example, the pharmaceutical composition may be a non-oral dosage form, and the non-oral dosage form may be a rectal, topical, subcutaneous, or transdermal dosage form, such as an injection, a drip, an ointment, an emulsion, a gel, a cream, a spray, a suspension, an oil, a suppository, a patch, etc., but is not limited thereto.

[0039] As an embodiment, the dosage of the pharmaceutical composition can be different according to the age, sex, weight and specific disease to be treated or pathological condition of the subject to be treated, the severity of the disease or pathological condition, the route of administration and the judgment of the prescriber. Taking these factors into account, the dosage is determined within the scope of the level of those skilled in the art. For example, the dosage can be 1mg / kg / to 10g / kg / day or 5mg / kg / to 100mg / kg / day range, but the dosage does not limit the scope of this specification in any way.

[0040] Hereinafter, the present disclosure will be described in detail with reference to embodiments, comparative examples and experimental examples, which are provided only as examples for the purpose of more specifically describing the present disclosure, and a person with ordinary knowledge in the art should understand that the scope of the present disclosure is not limited by the embodiments, comparative examples and experimental examples.

[0041] [Experimental Example 1] Comparison of Antioxidant Effects

[0042] The antioxidant efficacy of sodium pyruvate (product name: P5280, manufacturer: Sigma Aldrich) of one embodiment of the present disclosure and glutathione (GSH, product name: G6013, manufacturer: Sigma Aldrich) and glyoxylic acid (product name: 260150, manufacturer: Sigma Aldrich) as antioxidants were compared and evaluated. The antioxidant efficacy was evaluated by the FOX (Ferrous Oxidation-Xylenol Orange) 2 analysis method to evaluate the H2O2 removal ability. The antioxidant efficacy using the FOX2 analysis method was determined by the following method: H2O2 and Fe 2+ The Fe generated by the reaction 3+ Combines with xylenol orange to form Fe 3+ -xylenol orange complex, and the yellow color changes to purple. If it is an antioxidant substance, the purple color change will weaken when H2O2 is removed. Sodium pyruvate, glutathione and glyoxylic acid were added to 100μM H2O2 at concentrations of 10ppm, 20ppm, 50ppm and 100ppm, respectively, and reacted at 37°C for 1 hour. Then, after reacting it using a peroxide analysis kit (23285, Thermo Scientific), the absorbance was measured to determine the remaining H2O2 amount.

[0043] The results, such as Figure 1 As shown, at concentrations of 10 ppm, 20 ppm, 50 ppm, and 100 ppm, sodium pyruvate, glutathione, and glyoxylic acid all have excellent H2O2 removal capabilities, thereby showing similar antioxidant effects.

[0044] [Experimental Example 2] Comparison of the antioxidant effects of vitamin C according to the type of antioxidant

[0045] The antioxidant effects of sodium pyruvate, an embodiment of the present disclosure, which were confirmed to have similar antioxidant effects by Experimental Example 1, and glutathione (GSH) and glyoxylic acid as antioxidants were compared and evaluated. Once oxidized, vitamin C changes color to yellow and its potency decreases. Therefore, a spectrophotometer (product name: SPECTROstar) was used to measure the antioxidant effects of vitamin C. Absorbance Plate Reader, manufacturer: BMG LABTECH) was used to measure the absorbance at 560nm to confirm the color change of vitamin C, so as to compare the antioxidant effect of vitamin C. Specifically, after adding 200μl of vitamin C solution (product name: A4403, manufacturer: Sigma Aldrich) to a 96-well plate, a fresh 10% vitamin C aqueous solution was prepared as a blank for standby use. The 10% vitamin C aqueous solution was stored at 40°C for 8 weeks, and the absorbance changes after 0 weeks, 1 week, 2 weeks, 4 weeks and 8 weeks were measured at 560nm using a spectrophotometer to obtain Figure 2 The results of OD (optical density) were used as the standard curve in the following experiments.

[0046] Then, each solution was prepared according to the composition in the following table, stored at 40° C. for 4 weeks, and the change in absorbance after 4 weeks was measured.

[0047] [Table 1]

[0048]

[0049]

[0050] (Unit: weight %)

[0051] As a result, in Experimental Example 1, sodium pyruvate, glutathione, and glyoxylic acid all showed excellent antioxidant activity. However, glyoxylic acid, unlike glutathione and sodium pyruvate, promoted the oxidation of vitamin C (refer to Figure 3 as well as Figure 4 ). This means that not all substances that simply serve as antioxidants can prevent the oxidation of vitamin C, and the antioxidant effect of vitamin C, that is, the stability effect of vitamin C, is a special effect of pyruvate as an active ingredient of the present invention.

[0052] In addition, Comparative Example 1 containing 0.05 wt% of glutathione hardly exhibited the antioxidant effect of vitamin C, whereas Example 1 containing 0.05 wt% of sodium pyruvate, which is the active ingredient of the present invention, had a higher effect of preventing the oxidation of vitamin C than Comparative Example 2 containing 0.2 wt% of glutathione. This indicates that even if the amount of pyruvate, which is the active ingredient of the present invention, is smaller than that of glutathione used as a conventional vitamin C antioxidant, it exhibits an excellent vitamin C antioxidant effect.

[0053] [Experimental Example 3] Comparison of the antioxidant effect of vitamin C based on pyruvate concentration

[0054] As an example of the present disclosure, the antioxidant efficacy of vitamin C based on the pyruvate concentration was compared and evaluated.

[0055] In the same manner as in Experimental Example 2, compositions containing 10 wt % of natural vitamin C and 0 wt %, 0.01 wt %, 0.02 wt %, 0.05 wt %, 0.2 wt % or 1 wt % of sodium pyruvate, respectively, relative to the total weight of the composition were prepared, and the antioxidant efficacy of vitamin C was compared.

[0056] The results, such as Figure 5 as well as Figure 6 As shown in the graph, the antioxidant effect of vitamin C was fully confirmed at 0.01 wt % to 1 wt % of sodium pyruvate, and when the content of sodium pyruvate was 0.2 wt % or more, the increase in the antioxidant effect of vitamin C tended to decrease.

[0057] [Experimental Example 4] Comparison of the antioxidant effects of vitamin C based on the types of pyruvate derivatives

[0058] The antioxidant effects of vitamin C based on pyruvate derivatives as one embodiment of the present disclosure were compared and evaluated.

[0059] In the same manner as in Experimental Example 2, compositions containing 10 wt % of natural vitamin C and 0.05 wt % or 0.2 wt % of sodium pyruvate, methyl pyruvate or ethyl pyruvate were prepared relative to the total weight of the composition, and the antioxidant effect of vitamin C was compared.

[0060] The results, such as Figure 7 as well as Figure 8 As shown, all three pyruvates showed efficacy in preventing vitamin C oxidation.

[0061] [Experimental Example 5] Comparison of dosage form stability of compositions based on pyruvate content

[0062] The dosage form stability of the composition based on the pyruvate content as one embodiment of the present disclosure was compared and evaluated.

[0063] Using vitamin C solution (product name: A4403, manufacturer: Sigma Aldrich) and sodium pyruvate (product name: P5280, manufacturer: Sigma Aldrich), emulsion compositions were prepared according to the components in the following table, and the viscosity of each composition was measured at 30°C for 2 minutes using a Brookfield viscometer LVF. The measured value was expressed as a ratio relative to the composition not containing pyruvate, and was expressed as Fig. 9 Shown in.

[0064] [Table 2]

[0065]

[0066]

[0067] (Unit: weight %)

[0068] As a result, when the content of pyruvate was 0.5 wt % or more, the viscosity of the dosage form decreased, and it was confirmed that when the weight of pyruvate was less than 0.5 wt % relative to 10 wt % of vitamin C, the dosage form was stable.

[0069] [Experimental Example 6] Comparison of the antioxidant effect of vitamin C based on vitamin C content

[0070] As one embodiment of the present disclosure, the antioxidant efficacy of vitamin C based on the vitamin C content was compared and evaluated.

[0071] In the same manner as in Experimental Example 2, compositions containing 10 wt % of natural vitamin C and 0 wt %, 0.05 wt %, 0.2 wt % or 1 wt % of sodium pyruvate relative to the total weight of the composition were prepared, and the antioxidant efficacy of vitamin C was compared.

[0072] The results, such as Fig.10 as well as Fig.11 As shown, at 10 wt % and 20 wt % vitamin C, the vitamin C antioxidant effect of pyruvate was fully demonstrated.

[0073] As an embodiment of the present disclosure, the following implementation modes may be provided.

[0074] In a first embodiment, there is provided an additive composition for preventing oxidation of vitamin C or a vitamin C derivative in a cosmetic composition containing vitamin C or a vitamin C derivative, wherein the additive composition contains pyruvic acid or pyruvate as an active ingredient.

[0075] A second embodiment is the additive composition according to the first embodiment, wherein the vitamin C derivative includes at least one selected from the group consisting of sodium ascorbyl phosphate (SAP), magnesium ascorbyl phosphate (MAP), calcium ascorbyl phosphate, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl stearate, ascorbyl glucoside and ascorbyl ethylsilanol pectinate.

[0076] A third embodiment is the additive composition according to one or more of the first and second embodiments, wherein the pyruvate includes at least one selected from the group consisting of sodium pyruvate, methyl pyruvate, and ethyl pyruvate.

[0077] A fourth embodiment is the additive composition according to one or more of the first to third embodiments, wherein the pyruvic acid or pyruvic acid salt is added in an amount of 0.001 wt % to 10 wt % based on the total weight of the cosmetic composition.

[0078] A fifth embodiment is the additive composition according to one or more of the first to fourth embodiments, wherein the pyruvic acid or pyruvic acid salt is added in an amount of 0.01 wt % to 1 wt % based on the total weight of the cosmetic composition.

[0079] A sixth embodiment is the additive composition according to one or more of the first to fifth embodiments, wherein the weight ratio of vitamin C or a vitamin C derivative to pyruvic acid or a pyruvic acid salt contained in the cosmetic composition is 5 to 30:0.01 to 1.

[0080] A seventh embodiment is the additive composition according to one or more of the first to sixth embodiments, wherein the weight ratio of vitamin C or a vitamin C derivative to pyruvic acid or a pyruvate salt contained in the cosmetic composition is 10 to 20:0.01 to 1.

[0081] An eighth embodiment provides a cosmetic composition including vitamin C or a vitamin C derivative and one or more additive compositions according to the first to seventh embodiments.

[0082] A ninth embodiment provides a use of pyruvic acid or pyruvate, wherein in one or more of the first to eighth embodiments, the pyruvic acid or pyruvate is used as an active ingredient in the preparation of an additive for preventing oxidation of vitamin C or a vitamin C derivative in a cosmetic composition containing vitamin C or a vitamin C derivative.

[0083] A tenth embodiment provides a use according to one or more of the first to ninth embodiments, wherein the vitamin C derivative includes one or more selected from the group consisting of sodium ascorbyl phosphate (SAP), magnesium ascorbyl phosphate (MAP), calcium ascorbyl phosphate, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl stearate, ascorbyl glucoside, and ascorbyl ethylsilanolpectinate.

[0084] An eleventh embodiment provides a use, wherein in one or more of the first to tenth embodiments, the pyruvate includes one or more selected from the group consisting of sodium pyruvate, methyl pyruvate, and ethyl pyruvate.

[0085] A twelfth embodiment provides a use, wherein in one or more of the first to eleventh embodiments, the pyruvic acid or pyruvic acid salt is added in an amount of 0.001 wt % to 10 wt % relative to the total weight of the cosmetic composition.

[0086] A thirteenth embodiment provides a use, wherein in one or more of the first to twelfth embodiments, the pyruvic acid or pyruvic acid salt is added in an amount of 0.01 wt % to 1 wt % relative to the total weight of the cosmetic composition.

[0087] A fourteenth embodiment provides a use, wherein in one or more of the first to thirteenth embodiments, the weight ratio of vitamin C or a vitamin C derivative to pyruvic acid or a pyruvate salt contained in the cosmetic composition is 5 to 30:0.01 to 1.

[0088] A fifteenth embodiment provides a use, wherein in one or more of the first to fourteenth embodiments, the weight ratio of vitamin C or a vitamin C derivative to pyruvic acid or a pyruvate salt contained in the cosmetic composition is 10 to 20:0.01 to 1.

[0089] The following describes an example of a dosage form of a composition according to an embodiment of the present disclosure. However, it can also be applied in various other dosage forms. It is only used for specific description and is not used to limit this specification.

[0090] [Dosage Form Example 1]

[0091] According to the components described in the following table, a cosmetic composition of a cream was prepared by a conventional method.

[0092] [Table 3]

[0093]

[0094]

[0095]

[0096] The embodiments are disclosed for the purpose of illustrating the present disclosure, and the description is not intended to limit the scope of the present disclosure. Therefore, various modifications, variations and substitutions may be made by a person skilled in the art without departing from the meaning and scope of the present disclosure.

Claims

1. Use of pyruvic acid or pyruvic acid salt, wherein the pyruvic acid or pyruvic acid salt is used as an effective ingredient for preparing an additive for preventing oxidation of vitamin C in a cosmetic composition containing vitamin C, The pyruvate salt includes at least one selected from the group consisting of sodium pyruvate, methyl pyruvate, and ethyl pyruvate.

2. The use according to claim 1, wherein The pyruvic acid or pyruvic acid salt is added in an amount of 0.001 wt % to 10 wt % relative to the total weight of the cosmetic composition.

3. The use according to claim 1, wherein The pyruvic acid or pyruvic acid salt is added in an amount of 0.01 wt % to 1 wt % relative to the total weight of the cosmetic composition.

4. The use according to claim 1, wherein The weight ratio of vitamin C to pyruvic acid or pyruvic acid salt contained in the cosmetic composition is 5-30:0.01-1.

5. The use according to claim 1, wherein The weight ratio of vitamin C to pyruvic acid or pyruvic acid salt contained in the cosmetic composition is 10-20:0.01-1.

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