Manipulation device and macro-micro electrode with the same

Abstract

This application provides a manipulation device and a macro-microelectrode having the device. The device includes: a housing defining a cavity for accommodating an electrode bundle passing through a first tube of a macroelectrode and a second tube of a microelectrode; a surface marked with graduations; a slider slidably connected to the housing, the slider having at least: a fixed portion located within the cavity, the fixed portion defining a channel distributed along the extension direction of the electrode bundle, the electrode bundle being movable within the first and second tubes under the action of the slider; and a marking portion exposed from the surface. This application can prevent the electrode bundle from twisting or bending within the macroelectrode tube during movement, avoiding any impact on the accuracy of the measurement results.

Description

Technical Field

[0001] Embodiments of this application relate to the field of medical device technology, and more particularly to a manipulator and a macro-microelectrode having the device. Background Technology

[0002] Microelectrodes are a tool used in medicine to study cells. The most common method for obtaining in vivo neuronal activity is to perform extracellular recording by placing microfilaments (<60μm) close to intact neurons. Macroelectrodes utilize macroelectrodes implanted within tissues. While the macroelectrode receives macroscopic clinical information, the microelectrode is moved under micromanipulation. When the microelectrode is close enough to a neuron, it can obtain the activity of a single cell, completing the extracellular neuronal recording. If this is not possible, it is still possible to record the activity of multiple cell units from a larger cluster of cells near the recording point. Currently, most macroelectrodes and microelectrodes are assembled in separate units. After assembly, the electrode bundle has a short range of motion, and there is a possibility that the electrode bundle may be twisted or bent, thus affecting signal reception. Summary of the Invention

[0003] To address the technical problems mentioned above, embodiments of this application provide a manipulation device and a macro / micro electrode having the device.

[0004] In a first aspect of this application, a control device is provided, comprising: a control device comprising:

[0005] The housing, the housing defining:

[0006] A cavity for accommodating the electrode bundle passing through the first tube of the macro electrode and the second tube of the micro electrode;

[0007] A surface marked with graduations;

[0008] The slider is slidably connected to the housing, and the slider has at least the following characteristics:

[0009] The fixing part is located within the cavity and defines a channel distributed along the extension direction of the electrode bundle. The electrode bundle can move within the first tube and the second tube under the action of the slider.

[0010] The markings are exposed from the surface.

[0011] In one possible implementation, the housing includes a base and a panel, the base having a groove, the panel being disposed on the upper surface of the base to cover the groove, the upper surface of the panel forming the plane, and the panel and the groove together defining the cavity.

[0012] In one possible implementation, a slide is provided on the opposite sidewall of the groove, and the slider is slidably disposed in the slide.

[0013] In one possible implementation, the slider is provided with a sub-slider, which is slidably disposed within the slide rail.

[0014] In one possible implementation, the cavity is filled with a filler for fixing the electrode bundle.

[0015] In one possible implementation, the electrode bundle is secured within the cavity by a clamping or locking device.

[0016] In one possible implementation, a reinforcing tube is also included, with a portion of the reinforcing tube disposed within the first tube body and a portion of the reinforcing tube fixed within the cavity, and the electrode bundle passing through the reinforcing tube.

[0017] In one possible implementation, the housing has a slide rail that matches the scale, and the slider has a sub-slider that cooperates with the slide rail, the sub-slider being disposed within the slide rail.

[0018] In a second aspect of this application, a macro-microelectrode is provided, comprising:

[0019] The aforementioned operating device;

[0020] The macroelectrode and microelectrode are connected to the housing of the control device. The cavity of the control device, the first tube of the macroelectrode, and the second tube of the microelectrode together define a channel for the movement of the electrode bundle.

[0021] In one possible implementation, the first tube is disposed on one side of the housing, and the second tube is disposed on the other side of the housing; and the first tube and the second tube are disposed facing each other.

[0022] In the manipulation device and macro / microelectrode with the device provided in the embodiments of this application, the housing defines a cavity and a surface with a scale. The slider has a fixed part and a marking part. The fixed part is located in the cavity and defines a channel distributed along the extension direction of the electrode bundle. The electrode bundle can move in the first tube and the second tube under the drive of the slider. The marking part is exposed from the surface. The distance the electrode bundle moves can be known according to the scale on the surface. Furthermore, due to the fixed part on the slider, the electrode bundle can be prevented from twisting or bending in the macroelectrode tube during movement, thus avoiding the influence on the accuracy of the measurement results.

[0023] It should be understood that the description in the Summary Section is not intended to limit the key or essential features of the embodiments of this application, nor is it intended to restrict the scope of this application. Other features of this application will become readily apparent from the following description. Attached Figure Description

[0024] The above and other features, advantages, and aspects of the embodiments of this application will become more apparent from the accompanying drawings and the following detailed description. In the drawings, the same or similar reference numerals denote the same or similar elements, wherein:

[0025] Figure 1 A schematic diagram of the structure in which the manipulation device and macro / micro electrodes are fitted together according to an embodiment of this application is shown.

[0026] Figure 2 It shows Figure 1 Cross-sectional view along the AA direction.

[0027] in:

[0028] 10. Shell; 11. Cavity; 12. Flat surface; 101. Base; 102. Panel; 103. Groove; 104. Slide rail;

[0029] 20. Slider; 21. Marking part; 22. Fixing part; 23. Cavity; 201. Sub-slider;

[0030] 31. First tube body; 32. Reinforcing tube; 33. Second tube body; 34. Electrode bundle. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0032] In this application, a macro-microelectrode is implanted into human tissue using a macroelectrode. While the macroelectrode receives macroscopic clinical information, the electrode bundle of the microelectrode moves under the action of a manipulation device. When the electrode bundle of the microelectrode moves to the vicinity of a complete neuron, the activity of a single cell can be obtained, completing the recording of extracellular neurons, or the activity of multiple cell units can be recorded from a larger cell aggregation point near the recording point. The manipulation device may include a housing 10 and a slider 20. The slider 20 can fix the electrode bundle 34 in the macro-microelectrode. Under the action of the slider 20, the electrode bundle 34 can be moved to the vicinity of a complete neuron to record cell activity. During the movement of the electrode bundle 34, the movement distance of the electrode bundle 34 can be controlled by the cooperation of the housing 10 and the slider 20, while also preventing the electrode bundle 34 from twisting or bending during its movement within the macroelectrode tube.

[0033] See Figure 1 The housing 10 defines a cavity 11 inside and a plane 12 on its outer surface. The slider 20 is slidably connected to the housing 10. In one possible implementation, the slider 20 slides along the extension direction of the electrode bundle 34. See also [link to another implementation]. Figure 2 The housing 10 can be formed by a base 101 and a panel 102. A groove 103 is provided on the base 101. The panel 102 is provided on the upper surface of the base 103 to cover the groove 103. The upper surface of the panel forms a plane 12. The cavity 11 is defined by the panel 102 and the groove 103. A slide rail 104 is provided on two opposite side walls of the groove 103. A sub-slider 201 is provided on the slider 20. The sub-slider 201 is disposed in the slide rail 104. Through the cooperation of the sub-slider 201 and the slide rail 104, the relative sliding of the slider 20 and the housing 10 can be realized.

[0034] The slider 20 has at least a fixed portion 22 and a marking portion 21. The fixed portion 22 is located within a cavity 11, the size of which is adapted to allow the fixed portion 22 to move within it. The marking portion 21 protrudes from the surface of the housing 10 and has graduations on a plane 12. These graduations on the plane 12 indicate the distance the slider 20 slides relative to the housing 10. The fixed portion 22 defines a channel 23 distributed along the extension direction of the electrode bundle 34. The electrode bundle 34 is fixed within the channel 23 and is movable as the slider 20 moves.

[0035] See also Figure 1One side of the housing 10 can be connected to the first tube 31 of the macro electrode, and the other side can be connected to the second tube 33 of the micro electrode. Both the first tube 31 and the second tube 33 have portions located within the cavity 11, thus defining a channel for the movement of the electrode bundle. That is, the electrode bundle 34 is distributed among the first tube 31, the cavity 11, and the second tube 33. The electrode bundle 34 located within the cavity 11 passes through the channel 23 on the fixing portion 22 of the slider 20. To fix the electrode bundle 34 within the channel 23 so that it can move with the slider 20, a filler can be added to the channel 23 to fix the electrode bundle 34 within it. In one possible embodiment, the channel 23 can be filled with filler adhesive to fix the electrode bundle 34. In other possible embodiments, the electrode bundle 34 can be fixed by other means, such as by a clamping or locking device. Furthermore, the first tube 31 and the second tube 33 are arranged opposite each other, so that the electrode bundle 34 can move linearly along its extension direction, and the part of the electrode bundle 34 located in the first tube 31 is prevented from twisting or bending when it moves in the channel where it can move.

[0036] Because the distance the internal space of cavity 11 moves relative to the electrode bundle 34 is relatively large, the electrode bundle 34 may be twisted or bent within the first tube 31 as it moves with the slider. To avoid this, a reinforcing tube 32 can be provided within the first tube 31. Specifically, one end of the reinforcing tube 32 extends into the portion of the first tube 31 near cavity 11, and the other end extends into and is fixed to the cavity 23 of the slider 20. The electrode bundle 34 passes through the reinforcing tube 32, preventing it from twisting or bending as the slider 20 moves it.

[0037] In one possible implementation, the fixed portion of the slider 20 can be configured with both the surface facing the first tube 31 and the surface facing the second tube 33 as arc-shaped surfaces, i.e. Figure 1 In the direction shown, the width of the fixed part 22 gradually decreases from top to bottom. This arrangement can prevent the slider 20 from touching the first tube 31 or the second tube 33 during sliding, thereby increasing the movement distance of the slider 20 in the cavity 11.

[0038] According to an embodiment of this application, the housing defines a cavity and a surface with graduations. The slider has a fixed portion and a marking portion. The fixed portion is located inside the cavity and defines a channel distributed along the extension direction of the electrode bundle. The electrode bundle can move in the first tube and the second tube under the action of the slider. The marking portion is exposed from the surface. The distance the electrode bundle has moved can be determined according to the graduations on the surface. Furthermore, due to the fixed portion on the slider, the electrode bundle can be prevented from twisting or bending in the macro electrode tube during movement, thus avoiding any impact on the accuracy of the measurement results.

[0039] The above description is merely a preferred embodiment of this application and an explanation of the technical principles employed. Those skilled in the art should understand that the scope of this application is not limited to technical solutions formed by specific combinations of the above-described technical features, but should also cover other technical solutions formed by arbitrary combinations of the above-described technical features or their equivalents without departing from the foregoing application concept. For example, technical solutions formed by substituting the above features with (but not limited to) technical features with similar functions claimed in this application.

Claims

1. A control device, characterized in that, The device includes: a housing defining a cavity for accommodating an electrode bundle passing through a first tube of a macroelectrode and a second tube of a microelectrode; a surface marked with graduations; and a slider slidably connected to the housing, the slider having at least: a fixing portion located within the cavity, the fixing portion defining a channel distributed along the extension direction of the electrode bundle, the channel being filled with a filler for fixing the electrode bundle, the electrode bundle being movable within the first tube and the second tube under the action of the slider; and a marking portion exposed from the surface. It also includes a reinforcing tube, part of which is disposed in the first tube body and part of which is fixed in the cavity, and the electrode bundle passes through the reinforcing tube.

2. The operating device according to claim 1, characterized in that, The housing includes a base and a panel. The base has a groove, and the panel is provided on the upper surface of the base to cover the groove. The upper surface of the panel forms a plane, and the panel and the groove together define the cavity.

3. The operating device according to claim 2, characterized in that, A slide rail is provided on the opposite side wall of the groove, and the slider is slidably disposed in the slide rail.

4. The operating device according to claim 3, characterized in that, The slider is provided with a sub-slider, which is slidably disposed within the slide rail.

5. The operating device according to claim 1, characterized in that, The electrode bundle is fixed inside the cavity by a clamping or locking device.

6. The operating device according to claim 1, characterized in that, The housing has a slide rail that matches the scale, and the slider has a sub-slider that cooperates with the slide rail. The sub-slider is disposed in the slide rail.

7. A macro-microelectrode, characterized in that, include: The operating device as described in any one of claims 1 to 5; The macroelectrode and microelectrode are connected to the housing of the control device. The cavity of the control device, the first tube of the macroelectrode, and the second tube of the microelectrode together define a channel for the movement of the electrode bundle.

8. The macro-microelectrode according to claim 7, characterized in that, The first tube is disposed on one side of the housing, and the second tube is disposed on the other side of the housing; and the first tube and the second tube are disposed opposite each other.

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