Active magnetic stimulation neural modulation device

Abstract

The present invention discloses an active magnetic stimulation nerve modulation device, the modulation device comprises an intracranial magnetic source module and a magnetic stimulation module, the intracranial magnetic source module utilizes mature intracranial cavities such as arteries, veins, and cerebrospinal fluid as implantation channels, the intracranial magnetic source module comprises a magnetic bracket, a magnetic component is arranged on the magnetic bracket, the magnetic stimulation module comprises a fixing mechanism and a magnetic field generating module, the magnetic field generating module generates a magnetic field to cooperate with the magnetic bracket on the intracranial magnetic source module to modulate nerves, the magnetic component comprises a magnetic material, and the magnetic material is covered on the magnetic bracket. The modulation device of the present invention is accurately delivered through interventional surgery to increase the targeting of treatment, by increasing the intracranial active magnetic field, setting a plurality of endogenous magnetic fields, and increasing the focusing of magnetic stimulation for different targets, due to the existence of the endogenous magnetic field, the stimulation time is prolonged, and continuous stimulation can be performed, and active magnetic stimulation makes up for the shortcomings of existing TMS and improves the efficacy of neurological disease treatment.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, in particular to an active magnetic stimulation nerve modulation device. Background Art

[0002] Transcranial magnetic stimulation, as a non-invasive and non-intrusive neuromodulation technology, has important applications in the exploration of the causes of mental disorders and the treatment of mental illnesses. The performance of the TMS system directly affects the neuromodulation effect, but there is still a contradiction between the performance level of the existing TMS system and the performance requirements of clinical applications and scientific research that needs to be resolved. The traditional TMS coil has the problems of insufficient intracranial induced electric field stimulation intensity, low focus, and poor targeting. In addition, the existing magnetic stimulation mechanism also has the problems of large required magnetic field strength, short action distance, insufficient accuracy, and inconvenient use.

[0003] In view of the above existing problems, an active magnetic stimulation neural modulation device is designed. Summary of the invention

[0004] The purpose of the present invention is to provide an active magnetic stimulation neural modulation device to solve the problems of insufficient intracranial induced electric field stimulation intensity, low focusing, poor targeting, large required magnetic field intensity, short action distance and insufficient accuracy in existing transcranial magnetic stimulation.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] An active magnetic stimulation neural modulation device comprises an intracerebral magnetic source module and a magnetic stimulation module.

[0007] The intra-brain magnetic source module comprises a magnetic bracket, on which a magnetic piece is arranged.

[0008] The magnetic stimulation module includes a fixing mechanism and a magnetic field generating module. The magnetic field generating module generates a magnetic field and cooperates with the magnetic bracket on the intracerebral magnetic source module to modulate the nerves.

[0009] Furthermore, the magnetic member includes magnetic material, the magnetic material is covered on the magnetic support, and the magnetic material includes magnetic material particles, magnetic nano-hydrogel particles and magnetic nano-hydrogel particle strips.

[0010] Furthermore, the magnetic stent comprises a micro-electromagnetic device with a magnetic material as a skeleton, covered with a biocompatible material on the outside, and delivered into a blood vessel, and the magnetic stent is made of a degradable material;

[0011] The magnetic stent is directly used to block some unimportant blood vessels deep in the brain. As an internal magnetic source, the magnetic stent produces neuromodulation effects by generating electricity, magnetism, and heat alone. Two or more magnetic stents are set up to target different targets and achieve multi-target stimulation to improve the therapeutic effect.

[0012] Furthermore, the fixing mechanism includes a first support link and a second support link, the first support link is fastened to the second support link, the magnetic field generating module includes a first magnetic stimulation member, a first magnetic stimulation block, a second magnetic stimulation member and a second magnetic stimulation block, and the magnetic stimulation module is fixed to the patient's head through the fixing mechanism.

[0013] Furthermore, a first magnetic stimulation component is provided on one side of the first supporting link, and an array-distributed first magnetic stimulation block is provided on the first magnetic stimulation component; a connecting seat is provided on the second supporting link, a mounting block is fastened to one side of the connecting seat, and a second magnetic stimulation component is fastened to the other side, a second magnetic stimulation block is fastened to one side of the mounting block, and a symmetrically distributed fixing block is provided on one side of the second magnetic stimulation block.

[0014] The first magnetic stimulation member, the first magnetic stimulation block, the second magnetic stimulation member and the second magnetic stimulation block are electromagnetic devices capable of generating a magnetic field.

[0015] Furthermore, the magnetic field generating module includes a coil assembly, a pulsed electromagnetic field driving circuit and an electric pulse generator.

[0016] Furthermore, the magnetic stimulation module includes a shell, a processor is arranged in the shell, a coil assembly for generating a pulsed electromagnetic field is arranged in the shell, a power supply for supplying power to the coil assembly is arranged in the shell, and the coil assembly is electrically connected to the power supply.

[0017] The magnetic stimulation module includes a system regulator, a system voltage regulator, a pulse electromagnetic field drive circuit, and a pulse electromagnetic field voltage regulator. The system voltage regulator is provided with a user interface for user input convenience.

[0018] The magnetic stimulation module includes an electric pulse generator for generating current pulses and an electromagnetic coil. The electromagnetic coil adopts an eight-shaped symmetrical coil for transcranial magnetic stimulation, and the electromagnetic coil is electrically connected to the electric pulse generator.

[0019] The electromagnetic coil is formed by twisting Litz wires, and adjacent Litz wires are electrically connected.

[0020] Furthermore, the magnetic stimulation module is a magnetic cap made of magnetic material and is easy to wear.

[0021] Furthermore, the intracerebral magnetic source module utilizes mature intracranial cavities as implantation channels.

[0022] Furthermore, by changing the position of the magnetic source module in the brain and moving the fixed position of the magnetic stimulation module, magnetic stimulation can be performed on different nerve locations in the patient's head to treat different diseases.

[0023] Beneficial effects of the present invention:

[0024] 1. The modulation device of the present invention accurately delivers through minimally invasive technology, increases the targeting of treatment, reduces side effects, increases the focus of magnetic stimulation by increasing the intracranial active magnetic field, and has high accuracy. Due to the existence of the endogenous magnetic field, it reduces the requirements for external stimulation equipment, reduces the intensity required for stimulation, and has a short action distance;

[0025] 2. The modulation device of the present invention can have multiple endogenous magnetic fields, which can increase the focusing of magnetic stimulation for different targets, reduce side effects, and prolong the stimulation time, allowing continuous stimulation. Active magnetic stimulation makes up for the shortcomings of existing TMS, improves the efficacy of neuropsychiatric diseases, requires a small magnetic field, and is easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The present invention will be further described below in conjunction with the accompanying drawings.

[0027] Figure 1 It is a schematic diagram of the structure of the modulation device of the present invention;

[0028] Figure 2 The present invention Figure 1 The enlarged structural diagram at A in the middle;

[0029] Figure 3 It is a partial structural schematic diagram of the magnetic stimulation module of the present invention;

[0030] Figure 4 It is a schematic diagram of the structure of the modulation device of the present invention;

[0031] Figure 5 It is a schematic diagram of the structure of the modulation device of the present invention.

[0032] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0033] 1-brain magnetic source module, 2-magnetic stimulation module, 3-magnetic bracket, 4-first magnetic stimulation element, 5-first supporting rod, 6-second supporting rod, 7-connecting seat, 8-mounting block, 9-second magnetic stimulation block, 10-fixing block, 11-second magnetic stimulation element, 12-first magnetic stimulation block. DETAILED DESCRIPTION

[0034] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] An active magnetic stimulation neuromodulation device, such as Figure 1 , Figure 2As shown, the modulation device includes an intracerebral magnetic source module 1 and a magnetic stimulation module 2. The intracerebral magnetic source module 1 uses mature intracranial cavities such as arteries, veins, and cerebrospinal fluid as implantation channels, and uses interventional minimally invasive surgery to place the intracerebral magnetic source module 1 into blood vessels and deliver it to specific areas of the brain through blood vessels. Interventional minimally invasive surgery includes atherectomy, rotational atherectomy, ablation, angioplasty, stenting, and biological vascular stenting.

[0036] The intracerebral magnetic source module 1 comprises a magnetic support 3 , on which a magnetic material is covered. The magnetic material comprises magnetic material particles, magnetic nano-hydrogel particles and magnetic nano-hydrogel particle strips.

[0037] The magnetic bracket 3 may be made of a magnetic material as a framework and covered with a biocompatible material on the outside.

[0038] The magnetic support 3 can also be made of degradable materials, and can degrade by itself after completing the neuromodulation treatment to reduce the impact on the human body.

[0039] The magnetic stent 3 may also be a miniature electromagnetic device delivered into a blood vessel.

[0040] There can be multiple magnetic brackets 3 at the same time, targeting different targets, to achieve multi-target stimulation to improve the therapeutic effect.

[0041] The magnetic stent 3 is directly used to block some unimportant blood vessels deep in the brain. As an internal magnetic source, the magnetic stent 3 produces neuromodulatory effects by generating electricity, magnetism, and heat alone.

[0042] like Figure 3 As shown, the magnetic stimulation module 2 is a comfortable transcranial magnetic stimulation head cover, and can also be a comfortable transcranial magnetic stimulation ear cover. The magnetic stimulation module 2 includes a shell, which is in the shape of a hat. A processor is arranged in the shell, a coil assembly for generating a pulsed electromagnetic field is arranged in the shell, and a power supply for powering the coil assembly is arranged in the shell, wherein the coil assembly is electrically connected to the power supply. After the coil assembly is powered by the power supply, the coil assembly can generate a pulsed electromagnetic field. When the coil assembly is activated, the generated pulsed electromagnetic field interacts with the magnetic source module 1 in the brain to enhance the neural modulation effect.

[0043] The magnetic stimulation module 2 includes a first supporting link 5 for fixing the magnetic stimulation module 2, one side of the first supporting link 5 is fastened with a second supporting link 6, one side of the first supporting link 5 is provided with a first magnetic stimulation component 4, the first magnetic stimulation component 4 is provided with an array-distributed first magnetic stimulation block 12, the second supporting link 6 is provided with a connecting seat 7, one side of the connecting seat 7 is provided with a mounting block 8, and the other side is fastened with a second magnetic stimulation component 11, one side of the mounting block 8 is provided with a second magnetic stimulation block 9, and the other side is fastened with the connecting seat 7, one side of the second magnetic stimulation block 9 is provided with symmetrically distributed fixing blocks 10, and the other side is fastened with the mounting block 8.

[0044] The first magnetic stimulation element 4, the first magnetic stimulation block 12, the second magnetic stimulation element 11 and the second magnetic stimulation block 9 can be permanent magnetic stimulation mechanisms or electromagnetic mechanisms capable of generating magnetic fields. The electromagnetic mechanisms can generate magnetic fields of different frequencies and intensities through adjustment.

[0045] The magnetic stimulation module 2 includes a system regulator, a system voltage regulator, a pulsed electromagnetic field drive circuit, and a pulsed electromagnetic field voltage regulator. The system voltage regulator is provided with a user interface for the user to program the microcontroller to generate a desired electrical output signal to drive the coil assembly and adjust the magnetic field strength and frequency of the magnetic stimulation module 2 to promote neural modulation.

[0046] like Figure 4 , Figure 5 As shown, the magnetic stimulation module 2 includes an electric pulse generator and an electromagnetic coil. The electric pulse generator is used to generate current pulses. The electromagnetic coil adopts an eight-shaped symmetrical coil of transcranial magnetic stimulation to provide an exogenous magnetic field. The electromagnetic coil is electrically connected to the electric pulse generator and fixedly arranged on the patient's head to perform magnetic stimulation on the patient's head, change the position of the magnetic source module 1 in the brain, and move the fixed position of the magnetic stimulation module 2 at the same time to perform magnetic stimulation on different nerve positions of the patient's head to treat different diseases.

[0047] The electromagnetic coil is formed by twisting Litz wires, and any adjacent Litz wires are electrically connected.

[0048] The magnetic stimulation module 2 can be a magnetic cap made of magnetic material that is easy to wear and generates different magnetic field intensities to provide long-term neuromodulation treatment for patients.

[0049] The following embodiments are listed to further explain the active magnetic stimulation nerve modulation device of the present invention:

[0050] Example 1: Place the intracerebral magnetic source module 1 in the bilateral prefrontal cortex, biased towards the left side, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), bipolar disorder, and negative symptoms of schizophrenia.

[0051] Example 2: Placing the intracerebral magnetic source module 1 in the medial prefrontal lobe and orbitofrontal cortex, combined with an external magnetic stimulation device, both enhance the neuromodulation effect, for the treatment of autism and Asperger's syndrome.

[0052] Example 3: Place the intracerebral magnetic source module 1 in the bilateral insula and prefrontal cortex, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of tobacco and alcohol addiction.

[0053] Example 4: Place the intracerebral magnetic source module 1 in the bilateral prefrontal cortex, basal ganglia and other deep brain nuclei, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of Parkinson's disease.

[0054] Example 5: Place the intracerebral magnetic source module 1 into the unilateral prefrontal lobe (either left or right), and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), geriatric diseases, and schizophrenia-delusional symptoms.

[0055] Example 6: Placing the intracerebral magnetic source module 1 into the medial prefrontal lobe, including the anterior cingulate cortex (ACC), combined with an external magnetic stimulation device, both enhance the neuromodulation effect for the treatment of obsessive-compulsive disorder (OCD), migraine, blepharospasm, tourette syndrome, chronic pain, and cocaine addiction.

[0056] Example 7: Placing the intracerebral magnetic source module 1 in the insula (left, right or bilateral) and combining it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of obesity.

[0057] Example 8: The intracerebral magnetic source module 1 is placed in the bilateral parietal cortex, including the posterior cingulate cortex (PCC), and combined with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of Alzheimer's disease and mild cognitive impairment (MCI).

[0058] Example 9: Placing the intracerebral magnetic source module 1 into the motor-related cortex and combining it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of chronic neuropathic pain, multiple sclerosis, and rehabilitation of stroke patients.

[0059] Example 10: Place the intracerebral magnetic source module 1 at a relevant position next to the tumor, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect, which is used to treat tumors or modulate the blood-brain barrier for drug release in brain tumor patients.

[0060] Example 11: Place the intracerebral magnetic source module 1 in the bilateral insular circles, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of anorexia nervosa.

[0061] Example 12: Place the intracerebral magnetic source module 1 in the lateral temporal cortex (left or right), and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of childhood epilepsy.

[0062] Example 13: Place the intracerebral magnetic source module 1 in the left and right temporal cortices, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of low-functioning autism in children.

[0063] Example 14: The intracerebral magnetic source module 1 is placed in the cerebellum and motor cortex, and combined with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of Machado-Joseph disease (MJD).

[0064] Example 15: Place the intracerebral magnetic source module 1 in the basal ganglia of the cerebral artery M1, and combine it with an external magnetic stimulation device to enhance the neuromodulation effect for the treatment of Parkinson's disease and other diseases.

[0065] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0066] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.

Claims

1. An active magnetic stimulation neural modulation device, characterized in that: The modulation device comprises an intracerebral magnetic source module (1) and a magnetic stimulation module (2); The intracerebral magnetic source module (1) comprises a magnetic bracket (3), and a magnetic member is provided on the magnetic bracket (3); The magnetic stimulation module (2) comprises a fixing mechanism and a magnetic field generating module, wherein the magnetic field generating module generates a magnetic field which cooperates with a magnetic bracket (3) on the intracerebral magnetic source module (1) to modulate nerves; The fixing mechanism comprises a first supporting link (5) and a second supporting link (6), the first supporting link (5) and the second supporting link (6) are tightly connected, the magnetic field generating module comprises a first magnetic stimulation member (4), a first magnetic stimulation block (12), a second magnetic stimulation member (11) and a second magnetic stimulation block (9), and the magnetic stimulation module (2) is fixed to the patient's head via the fixing mechanism; The magnetic field generating module comprises a coil assembly, a pulsed electromagnetic field driving circuit and an electric pulse generator; The magnetic stimulation module (2) comprises a housing, a processor is arranged in the housing, a coil assembly for generating a pulsed electromagnetic field is arranged in the housing, a power supply for supplying power to the coil assembly is arranged in the housing, and the coil assembly is electrically connected to the power supply; The magnetic stimulation module (2) comprises a system regulator, a system voltage regulator, a pulse electromagnetic field drive circuit, and a pulse electromagnetic field voltage regulator, wherein the system voltage regulator is provided with a user interface for convenient user input; The magnetic stimulation module (2) comprises an electric pulse generator for generating current pulses and an electromagnetic coil, wherein the electromagnetic coil is an eight-shaped symmetrical coil for transcranial magnetic stimulation, and the electromagnetic coil is electrically connected to the electric pulse generator; The electromagnetic coil is formed by twisting Litz wires, and adjacent Litz wires are electrically connected.

2. The active magnetic stimulation neural modulation device according to claim 1, characterized in that: The magnetic member comprises a magnetic material, the magnetic material is covered on a magnetic support (3), and the magnetic material comprises magnetic material particles, magnetic nano-hydrogel particles and magnetic nano-hydrogel particle strips.

3. The active magnetic stimulation neural modulation device according to claim 2, characterized in that: The magnetic stent (3) comprises a micro-electromagnetic device with a magnetic material as a skeleton, an external coating of a biocompatible material, and delivered into a blood vessel. The magnetic stent (3) is made of a degradable material. The magnetic stent (3) is directly used to block some unimportant blood vessels deep in the brain. As an internal magnetic source, the magnetic stent (3) produces a neuromodulatory effect by generating electricity, magnetism, and heat alone. Two or more magnetic stents (3) are provided to achieve multi-target stimulation for different target points to improve the therapeutic effect.

4. The active magnetic stimulation neural modulation device according to claim 1, characterized in that: A first magnetic stimulation member (4) is provided on one side of the first supporting link (5), and a first magnetic stimulation block (12) distributed in an array is provided on the first magnetic stimulation member (4); a connecting seat (7) is provided on the second supporting link (6), a mounting block (8) is fastened to one side of the connecting seat (7), and a second magnetic stimulation member (11) is fastened to the other side; a second magnetic stimulation block (9) is fastened to one side of the mounting block (8), and a symmetrically distributed fixing block (10) is provided on one side of the second magnetic stimulation block (9); The first magnetic stimulation element (4), the first magnetic stimulation block (12), the second magnetic stimulation element (11) and the second magnetic stimulation block (9) are electromagnetic devices capable of generating a magnetic field.

5. The active magnetic stimulation neural modulation device according to claim 1, characterized in that: The magnetic stimulation module (2) is a magnetic cap made of magnetic material and is easy to wear.

6. The active magnetic stimulation neural modulation device according to claim 1, characterized in that: The intracerebral magnetic source module (1) utilizes a mature cavity in the skull as an implantation channel.

7. An active magnetic stimulation neural modulation device according to any one of claims 1 to 6, characterized in that: By changing the position of the magnetic source module (1) in the brain and moving the fixed position of the magnetic stimulation module (2), magnetic stimulation is performed on different nerve positions on the patient's head.

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