A craniotomy device for behavioral data collection in non-human primates

Abstract

The application discloses a craniotomy device for collecting behavior data of non-human primates, which comprises a craniotomy device body and a master control center, wherein the master control center is arranged outside the craniotomy device body and is used for controlling the action of the craniotomy device body; the craniotomy device body comprises a base and a craniotomy mechanism; the base is annular, a craniotomy positioning hole is formed in the center of the base, the base comprises two layers of shelf plates arranged oppositely and a measuring layer arranged between the two layers of shelf plates, a plurality of distance measuring sensors are arranged in the measuring layer at intervals with a preset distance, the detection heads of the distance measuring sensors are arranged towards the craniotomy positioning hole, and a guide rail is arranged on the shelf plate layer at the top end of the base along the craniotomy positioning hole; and the craniotomy mechanism is slidably arranged on the guide rail. The craniotomy device can grasp the cutting depth and effectively avoid damaging the brain tissue during cutting.

Description

Technical Field

[0001] This invention relates to the field of non-human primate behavioral data acquisition equipment, and in particular to a craniotomy device for non-human primate behavioral data acquisition. Background Technology

[0002] In medical experiments investigating specific diseases, collecting research data using laboratory animals is a crucial step, such as in studies of spinal cord injury. Monkeys are particularly suitable laboratory animals for spinal cord injury, and because acute spinal cord injury involves neurological aspects, data collection on nerve conduction status is also essential. Currently, nerve conduction detection primarily involves transcranial stimulation motor evoked potential (TCP) testing using a motor evoked potential electrophysiological analyzer. By comparing pre- and post-operative data, the detected nerve conduction status is used to assess nerve function recovery. After the testing is completed, craniotomy is performed on the monkeys used as laboratory animals to remove and preserve the brain.

[0003] However, current craniotomy surgeries generally use craniotomy cutting machines or high-frequency cutting knives. Both craniotomy cutting machines and high-frequency cutting knives require manual craniotomy. Before manual craniotomy, the size of the monkey's head is measured by the naked eye, and the depth of craniotomy is controlled based on the perceived size. However, measurements by the naked eye are prone to inaccuracy, making it difficult to control the cutting depth and easily damaging brain tissue. Summary of the Invention

[0004] The purpose of this invention is to provide a craniotomy device for collecting behavioral data of non-human primates.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A craniotomy device for collecting behavioral data of non-human primates includes a main body and a main control center. The main control center is located outside the main body and is used to control the movement of the main body. The main body includes a base and a craniotomy mechanism. The base is annular with a circular craniotomy positioning hole at its center. The base includes two opposing frame layers and a measuring layer between the two frame layers. Several ranging sensors are arranged at predetermined intervals along the ring line on the periphery of the measuring layer. The probes of the ranging sensors face into the craniotomy positioning hole. An annular guide rail is provided on the top frame layer of the base along the craniotomy positioning hole. The craniotomy mechanism is slidably mounted on the guide rail so that the craniotomy device can slide along the guide rail to perform craniotomy. After the non-human primate's head is inserted into the craniotomy positioning hole, the ranging sensors measure the head and transmit signals to the main control center. The main control center controls the craniotomy mechanism to perform craniotomy based on the measurement data.

[0007] As a further technical solution of the present invention: the craniotomy mechanism includes a base and a first driving mechanism. The bottom end of the base is provided with a first slider that is matched and installed with the guide rail, so that the base slides along the guide rail; the first driving mechanism is disposed on the base and is used to drive the base to slide along the guide rail.

[0008] As a further technical solution of the present invention: a rack is provided on the outer side of the guide rail, the rotating shaft of the first drive mechanism extends through the base and extends below the base, and a drive wheel that meshes with the rack is provided on the rotating shaft of the first drive mechanism. When the rotating shaft of the first drive mechanism rotates, the drive wheel and the rack cooperate to drive the base to move along the guide rail.

[0009] As a further technical solution of the present invention: the craniotomy mechanism includes a saw blade driving mechanism and a second driving mechanism; the top surface of the base is provided with a first slide rail extending toward the craniotomy positioning hole, the saw blade driving mechanism is slidably disposed on the first slide rail, and the end of the saw blade driving mechanism facing the craniotomy positioning hole is provided with a rotatable saw blade, which drives the saw blade to rotate; the second driving mechanism is disposed on the base and is used to drive the saw blade driving mechanism to slide back and forth along the first slide rail toward the craniotomy positioning hole.

[0010] As a further technical solution of the present invention: the second driving mechanism includes a first lead screw rotatably disposed on the top surface of the base and a first driving motor for driving the first lead screw to rotate. The first lead screw is disposed parallel to the first slide rail. A first movable block is screwed onto the first lead screw. The first movable block is connected to the saw blade driving mechanism. The first drive motor drives the first lead screw to rotate, thereby driving the saw blade driving mechanism to slide along the first slide rail.

[0011] As a further technical solution of the present invention: the craniotomy mechanism includes a longitudinal lifting platform, a lifting drive mechanism, a transverse slide rail seat, a grinding head drive mechanism, and a slide rail drive mechanism. The longitudinal lifting platform is erected on a base platform. The transverse slide rail seat is horizontally mounted on the longitudinal lifting platform and can be lifted and lowered. The lifting drive mechanism is mounted on the longitudinal lifting platform to drive the transverse slide rail seat to slide up and down on the longitudinal lifting platform. The grinding head drive mechanism is slidably erected on the transverse slide rail seat and the slide rail drive mechanism is mounted on the transverse slide rail seat to allow the grinding head drive mechanism to slide on the transverse slide rail seat. The lower end of the grinding head drive mechanism facing the craniotomy positioning hole is provided with a rotatable craniotomy grinding head, which is driven to rotate by the grinding head drive mechanism.

[0012] As a further technical solution of the present invention: the longitudinal lifting platform is provided with a lifting rail on the side facing the craniotomy positioning hole, and the lifting drive mechanism includes a second lead screw rotatably mounted on the longitudinal lifting platform and a second drive motor for driving the second lead screw to rotate. The second lead screw is arranged parallel to the lifting rail, and a slidable second movable block is provided on the second lead screw. The second movable block is connected to the transverse slide rail seat. The second drive motor drives the second lead screw to rotate, driving the transverse slide rail seat to rise and fall along the lifting rail.

[0013] As a further technical solution of the present invention: a second slider is provided on the side of the transverse slide rail facing the longitudinal lifting platform, and the second slider is slidably disposed on the lifting rail so that the transverse slide rail can move up and down along the lifting rail; a second slide rail is provided transversely on the side of the transverse slide rail away from the longitudinal lifting platform, and the grinding head drive mechanism is slidably disposed on the transverse slide rail along the second slide rail.

[0014] As a further technical solution of the present invention: the slide rail drive mechanism includes a third lead screw disposed on a transverse slide rail seat and a third drive motor for driving the third lead screw to rotate. The third lead screw is disposed parallel to the second slide rail. A slidable third movable block is provided on the third lead screw. The third movable block is connected to the grinding head drive mechanism. The third drive motor drives the third lead screw to rotate, thereby driving the grinding head drive mechanism to slide laterally along the second slide rail.

[0015] As a further technical solution of the present invention: the measuring layer is made of a buffer material.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: The present invention proposes a craniotomy device for collecting behavioral data of non-human primates. Through the cooperation between the main body of the craniotomy device and the main control center, a ranging sensor measures the skull and transmits signals to the main control center. When the craniotomy mechanism performs craniotomy on the monkey's head, the rotating shaft of the first drive mechanism rotates, driving the base to slide along the guide rail. While the base slides along the guide rail, the main control center controls the action of the craniotomy mechanism according to the measurement data. The craniotomy mechanism performs craniotomy on the monkey's head, thereby controlling the cutting depth and effectively avoiding damage to the brain tissue during cutting. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the craniotomy device used for collecting behavioral data from non-human primates in Example 1.

[0018] Figure 2 This is a sectional view of the base.

[0019] Figure 3 This is a schematic diagram of the craniotomy device used for collecting behavioral data from non-human primates in Example 2. Detailed Implementation

[0020] The specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for illustration and explanation only and are not intended to limit the scope of protection of the present invention.

[0021] Please see Figure 1 , Figure 2 and Figure 3 A craniotomy device for collecting behavioral data in non-human primates includes a main body 10 and a central control unit 20. The central control unit 20 is located outside the main body 10 and is used to control the movement of the main body 10. The main body 10 includes a base 11 and a craniotomy mechanism 12. The base 11 is annular, with a circular craniotomy positioning hole 101 formed at its center. The base 11 includes two opposing frame layers 111 and a measuring layer 112 disposed between the two frame layers 111. The measuring layer 112 is positioned at predetermined intervals along the annular line on its periphery. A plurality of ranging sensors 102 are provided, with the probes of the ranging sensors 102 facing into the craniotomy positioning hole 101. The base 11 has an annular guide rail 113 on the top shelf layer 111 along the craniotomy positioning hole 101. The craniotomy mechanism 12 is slidably mounted on the guide rail 113 for the craniotomy device to perform craniotomy. After the non-human primate head is inserted into the craniotomy positioning hole 101 and positioned, the plurality of ranging sensors 102 measure the head and transmit signals to the main control center 20. The main control center 20 controls the craniotomy mechanism 12 to operate according to the measurement data, and the craniotomy is performed through the craniotomy mechanism 12.

[0022] Furthermore, the measuring layer 112 is made of a buffer material to reduce the impact of vibration on the ranging sensor 102 during craniotomy by the craniotomy mechanism 12.

[0023] Furthermore, the craniotomy mechanism 12 includes a base 121 and a first drive mechanism 122. The bottom end of the base 121 is provided with a first slider that matches and is installed with the guide rail 113, so that the base 121 can slide along the guide rail 113. The first drive mechanism 122 is disposed on the base 121 and is used to drive the base 121 to slide along the guide rail 113.

[0024] Furthermore, a rack 303 is provided on the outer side of the guide rail 113. The rotating shaft of the first drive mechanism 122 extends through the base 121 and extends below the base 121. A drive wheel that meshes with the rack 303 is provided on the rotating shaft of the first drive mechanism 122. When the rotating shaft of the first drive mechanism 122 rotates, the drive wheel and the rack 303 cooperate, driving the base 121 to move along the guide rail 113.

[0025] Furthermore, the craniotomy structure of the craniotomy mechanism 12 can be flexibly designed. Different implementations exist depending on the design. This application provides two preferred embodiments.

[0026] Example 1:

[0027] See Figure 1 The craniotomy mechanism 12 further includes a saw blade driving mechanism 123 and a second driving mechanism 124; the top surface of the base 121 is provided with a first slide rail 301 extending toward the craniotomy positioning hole 101, the saw blade driving mechanism 123 is slidably disposed on the first slide rail 301, and a rotatable saw blade 302 is rotatably disposed at one end of the saw blade driving mechanism 123 toward the craniotomy positioning hole 101, and the saw blade 302 is driven to rotate by the saw blade driving mechanism 123; the second driving mechanism 124 is disposed on the base 121 and is used to drive the saw blade driving mechanism 123 to slide back and forth along the first slide rail 301 toward the craniotomy positioning hole 101.

[0028] Furthermore, the second drive mechanism 124 includes a first lead screw 31 rotatably mounted on the top surface of the base 121 and a first drive motor 32 for driving the first lead screw 31 to rotate. The first lead screw 31 is arranged parallel to the first slide rail 301. The first lead screw 31 is provided with a first movable block 33 that slides along the first lead screw 31 as it rotates. The first movable block 33 is connected to the saw blade drive mechanism 123. The first drive motor 32 drives the first lead screw 31 to rotate, thereby driving the saw blade drive mechanism 123 to slide along the first slide rail 301.

[0029] Understandably, the craniotomy method of the craniotomy device for collecting non-human primate behavioral data in Example 1 is as follows: The craniotomy device is used in conjunction with a limiting fixation mechanism to fix the monkey. After the monkey is fixed by the limiting fixation mechanism and its head is inserted into the craniotomy positioning hole 101, several ranging sensors 102 measure the head and transmit signals to the main control center 20. The main control center 20 controls the craniotomy mechanism 12 to operate based on the measurement data. The craniotomy mechanism 12 performs craniotomy on the monkey's head. The rotating shaft of the first drive mechanism 122 rotates, causing the base 121 to slide along the guide rail 113. While the base 121 slides along the guide rail 113, the main control center 20 controls the operation of the second drive mechanism 124 based on the measurement data. The first drive motor 32 drives the first lead screw 31 to rotate, adjusting the range of the drive saw blade drive mechanism 123 sliding along the first slide rail 301, thereby controlling the cutting depth and effectively avoiding damage to brain tissue during cutting.

[0030] Example 2:

[0031] See Figure 3The craniotomy mechanism 12 includes a longitudinal lifting platform 41, a lifting drive mechanism 42, a transverse slide rail 43, a grinding head drive mechanism 44, and a slide rail drive mechanism 45. The longitudinal lifting platform 41 is erected on a base. The transverse slide rail 43 is slidably and vertically mounted on the longitudinal lifting platform 41. The lifting drive mechanism 42 is mounted on the longitudinal lifting platform 41 to drive the transverse slide rail 43 to slide up and down on the longitudinal lifting platform 41. The grinding head drive mechanism 44 is erected on the transverse slide rail 43 and can slide back and forth toward the longitudinal lifting platform 41. The slide rail drive mechanism 45 is mounted on the transverse slide rail 43 to allow the grinding head drive mechanism 44 to slide back and forth toward the longitudinal lifting platform 41 on the transverse slide rail 43. The lower end of the grinding head drive mechanism 44 facing the craniotomy positioning hole 101 is provided with a rotatable craniotomy grinding head 441, which is driven to rotate by the grinding head drive mechanism 44.

[0032] Furthermore, the longitudinal lifting platform 41 is provided with lifting rails 411 on the side facing the craniotomy positioning hole 101 and the side facing the transverse slide rail seat 43, respectively. The transverse slide rail seat 43 is slidably mounted on the longitudinal lifting platform 41 along the lifting rails 411. The lifting drive mechanism 42 includes a second lead screw 421 rotatably mounted on the side of the longitudinal lifting platform 41 facing the craniotomy positioning hole 101 and a second drive motor 422 for driving the second lead screw 421 to rotate. The second lead screw 421 is parallel to the lifting rail 411 on the side of the longitudinal lifting platform 41 facing the craniotomy positioning hole 101. The second lead screw 421 is provided with a second movable block that slides along the second lead screw 421 as it rotates. The second movable block is connected to the transverse slide rail seat 43. The second drive motor 422 drives the second lead screw 421 to rotate, thereby driving the transverse slide rail seat 43 to slide up and down along the lifting rails 411.

[0033] Furthermore, a second slider is provided on the side of the transverse slide rail 43 facing the longitudinal lifting platform 41. The second slider is slidably mounted on the lifting rail 411, allowing the transverse slide rail 43 to slide up and down along the lifting rail 411. A second slide rail 431 is provided transversely on the side of the transverse slide rail 43 away from the longitudinal lifting platform 41. The grinding head drive mechanism 44 is slidably mounted on the transverse slide rail 43 along the second slide rail 431. The slide rail drive mechanism 45 includes components rotatably mounted on the side of the transverse slide rail 43 away from the longitudinal lifting platform 41. A third lead screw 451 is located on the side of the longitudinal lifting platform 41, and a third drive motor 452 is used to drive the third lead screw 451 to rotate. The third lead screw 451 is arranged opposite to the second slide rail 431. A third movable block is provided on the third lead screw 451, which rotates with the third lead screw 451 and slides along the third lead screw 451. The third movable block is connected to the grinding head drive mechanism 44. The third drive motor 452 drives the third lead screw 451 to rotate, thereby driving the grinding head drive mechanism 44 to slide laterally along the second slide rail 431.

[0034] Understandably, the craniotomy method of the craniotomy device for collecting non-human primate behavioral data in Example 2 is as follows: The craniotomy device is used in conjunction with a limiting and fixing mechanism to fix the monkey. After the monkey is fixed by the limiting and fixing mechanism and its head is inserted into the craniotomy positioning hole 101, several ranging sensors 102 measure the head and transmit signals to the main control center 20. The main control center 20 controls the horizontal slide rail 43 to slide up and down along the longitudinal lifting platform 41 and the grinding head drive mechanism 44 to slide laterally along the horizontal slide rail 43, moving the grinding head drive mechanism 44 to the center point of the monkey's head, establishing a zero point, forming a three-dimensional coordinate system in the main control center 20, and measuring the craniotomy. The coordinates of the position relative to the zero point are input into the main control center 20. The main control center 20 controls the craniotomy mechanism 12 to perform craniotomy on the monkey's head. The first drive mechanism 122 rotates, causing the base 121 to slide along the guide rail 113. While the base 121 slides along the guide rail 113, the main control center 20 controls the transverse slide rail seat 43 to slide up and down along the longitudinal lifting platform 41 and the grinding head drive mechanism 44 to slide laterally along the transverse slide rail seat 43 according to the measurement data. The craniotomy grinding head 441 of the grinding head drive mechanism 44 is adjusted to slide along the input track, thereby controlling the cutting area and depth and effectively avoiding damage to brain tissue during cutting.

[0035] In summary, the craniotomy device for collecting behavioral data of non-human primates of the present invention, through the cooperation between the main body 10 of the craniotomy device and the main control center 20, uses the ranging sensor 102 to measure the skull and transmit signals to the main control center 20. When the craniotomy mechanism 12 performs craniotomy on the monkey's head, the rotating shaft of the first drive mechanism 122 rotates, driving the base 121 to slide along the guide rail 113. While the base 121 slides along the guide rail 113, the main control center 20 controls the action of the craniotomy mechanism 12 according to the measurement data. By performing craniotomy on the monkey's head through the craniotomy mechanism 12, the cutting depth can be controlled, effectively avoiding damage to brain tissue during cutting.

[0036] Any combination of various embodiments of the present invention, provided it does not violate the inventive concept of the present invention, shall be regarded as the content disclosed by the present invention; within the scope of the technical concept of the present invention, any simple modifications to the technical solution and any combination of different embodiments that do not violate the inventive concept of the present invention shall be within the protection scope of the present invention.

Claims

1. A craniotomy device for collecting behavioral data in non-human primates, characterized in that: The device includes a craniotomy device body (10) and a main control center (20). The main control center (20) is located outside the craniotomy device body (10) and is used to control the movement of the craniotomy device body (10). The craniotomy device body (10) includes a base (11) and a craniotomy mechanism (12). The base (11) is ring-shaped, and a circular craniotomy positioning hole (101) is formed in the center of the base (11). The base (11) includes two layers of support plates (111) arranged opposite each other and a measuring layer (112) arranged between the two layers of support plates (111). Several distance measuring sensors (102) are arranged at preset distances along the ring line on the periphery of the measuring layer (112). The probe of the device (102) faces the craniotomy positioning hole (101). The base (11) has an annular guide rail (113) on the top shelf layer (111) along the craniotomy positioning hole (101). The craniotomy mechanism (12) can be slidably set on the guide rail (113) so that the craniotomy device can slide along the guide rail (113) to perform craniotomy. After the non-human primate head is inserted into the craniotomy positioning hole (101) for positioning, several distance sensors (102) measure the head and transmit signals to the main control center (20). The main control center (20) controls the craniotomy mechanism (12) to operate according to the measurement data and performs craniotomy through the craniotomy mechanism (12). The craniotomy mechanism (12) includes a base (121) and a first drive mechanism (122). The bottom end of the base (121) is provided with a first slider that matches and is installed with a guide rail (113), so that the base (121) slides along the guide rail (113). The first drive mechanism (122) is set on the base (121) to drive the base (121) to slide along the guide rail (113). A rack (303) is provided on the outer side of the guide rail (113). The shaft of the first drive mechanism (122) passes through the base (121) and extends to the bottom of the base (121). The shaft of the first drive mechanism (122) is provided with a drive wheel that meshes with the rack (303). When the shaft of the first drive mechanism (122) rotates, the drive wheel and the rack (303) cooperate to drive the base (121) to move along the guide rail (113). The craniotomy mechanism (12) includes a saw blade drive mechanism (123) and a second drive mechanism (124); the top surface of the base (121) is provided with a first slide rail (301) extending toward the craniotomy positioning hole (101), the saw blade drive mechanism (123) is slidably mounted on the first slide rail (301), and the end of the saw blade drive mechanism (123) facing the craniotomy positioning hole (101) is provided with a rotatable saw blade (302), which is driven to rotate by the saw blade drive mechanism (123); the second drive mechanism (124) is mounted on the base (121) and is used to drive the saw blade drive mechanism (123) to slide back and forth along the first slide rail (301) toward the craniotomy positioning hole (101); or, the craniotomy mechanism (12) includes a longitudinal lifting platform (41), a lifting drive mechanism (42), and a transverse slide rail seat (43). 43) Grinding head drive mechanism (44) and slide rail drive mechanism (45). The longitudinal lifting platform (41) is erected on the base (121). The transverse slide rail seat (43) is horizontally mounted on the longitudinal lifting platform (41) and the lifting drive mechanism (42) is mounted on the longitudinal lifting platform (41) to drive the transverse slide rail seat (43) to slide up and down on the longitudinal lifting platform (41). The grinding head drive mechanism (44) is slidably erected on the transverse slide rail seat (43). The slide rail drive mechanism (45) is mounted on the transverse slide rail seat (43) to allow the grinding head drive mechanism (44) to slide on the transverse slide rail seat (43). The lower end of the grinding head drive mechanism (44) facing the craniotomy positioning hole (101) is provided with a rotatable craniotomy grinding head (441). The craniotomy grinding head (441) is driven to rotate by the grinding head drive mechanism (44).

2. The craniotomy device according to claim 1, characterized in that: The second drive mechanism (124) includes a first lead screw (31) rotatably mounted on the top surface of the base (121) and a first drive motor (32) for driving the first lead screw (31) to rotate. The first lead screw (31) is arranged parallel to the first slide rail (301). A first movable block (33) is screwed onto the first lead screw (31). The first movable block (33) is connected to the saw blade drive mechanism (123). The first drive motor (32) drives the first lead screw (31) to rotate, thereby driving the saw blade drive mechanism (123) to slide along the first slide rail (301).

3. The craniotomy device according to claim 1, characterized in that: The longitudinal lifting platform (41) is provided with a lifting rail (411) on the side facing the craniotomy positioning hole (101). The lifting drive mechanism (42) includes a second lead screw (421) rotatably mounted on the longitudinal lifting platform (41) and a second drive motor (422) for driving the second lead screw (421) to rotate. The second lead screw (421) is arranged parallel to the lifting rail (411). The second lead screw (421) is provided with a slidable second movable block. The second movable block is connected to the transverse slide rail seat (43). The second drive motor (422) drives the second lead screw (421) to rotate, thereby driving the transverse slide rail seat (43) to rise and fall along the lifting rail (411).

4. The craniotomy device according to claim 1, characterized in that: The transverse slide rail seat (43) has a second slider on the side facing the longitudinal lifting platform (41). The second slider is slidably mounted on the lifting rail (411) so that the transverse slide rail seat (43) can move up and down along the lifting rail (411). The transverse slide rail seat (43) has a second slide rail (431) on the side away from the longitudinal lifting platform (41). The grinding head drive mechanism (44) is slidably mounted on the transverse slide rail seat (43) along the second slide rail (431).

5. The craniotomy device according to claim 4, characterized in that: The slide rail drive mechanism (45) includes a third lead screw (451) mounted on a transverse slide rail seat (43) and a third drive motor (452) for driving the third lead screw (451) to rotate. The third lead screw (451) is arranged parallel to the second slide rail (431). The third lead screw (451) is provided with a slidable third movable block. The third movable block is connected to the grinding head drive mechanism (44). The third drive motor (452) drives the third lead screw (451) to rotate, thereby driving the grinding head drive mechanism (44) to slide laterally along the second slide rail (431).

6. The craniotomy device according to claim 1, characterized in that: The measuring layer (112) is made of a cushioning material.

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