Methods of evaluating local or whole-body bone density using bioimpedance vector analysis

Abstract

The present invention discloses a method for evaluating local or whole-body bone density using a bioimpedance vector analysis technique, comprising: step (a) measuring the resistance and reactance of a subject by a bioimpedance measuring instrument, and obtaining the height of the subject, and then dividing the height of the subject by the resistance to obtain a first value, and dividing the height of the subject by the reactance to obtain a second value; step (b) comparing the first value and the second value with a bioimpedance vector analysis diagram, so as to evaluate the local or whole-body bone density of the subject, and the method is convenient in use.

Description

Technical Field

[0001] The present invention relates to bone density assessment technology, and in particular to a method for assessing local or whole body bone density using bioimpedance vector analysis technology. Background Art

[0002] Most bone density examination methods currently use dual energy X-ray absorptiometry (DXA) to measure bone density in terms of mineral mass (g / cm 2 ) is widely accepted to express bone mineral density (BMD).

[0003] However, although the DXA method for measuring BMD is accepted by everyone, it is expensive and must be measured in a hospital or related professional institution, so it cannot be used in home health care. In addition, each DXA measurement takes dozens of minutes. Therefore, the current method of measuring bone density with DXA is costly and time-consuming, and is not convenient to use. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] The main purpose of the present invention is to provide a method for evaluating local or whole-body bone density using bioimpedance vector analysis technology. Compared with the prior art, the present invention is low-cost, fast, and easy to use.

[0006] (II) Technical solution

[0007] In order to achieve the above-mentioned purpose, the present invention provides a method for evaluating local or whole body bone density using bioimpedance vector analysis technology, which comprises:

[0008] Step (a) measures the resistance (R) and reactance (Xc) of a subject by a bioimpedance meter, obtains the height of the subject, divides the height of the subject by the resistance to obtain a first value, and divides the height of the subject by the reactance to obtain a second value.

[0009] Step (b) compares the first value and the second value with a bioimpedance vector analysis diagram, thereby evaluating the local or whole body bone density of the subject.

[0010] (III) Beneficial effects

[0011] Therefore, the method provided by the present invention for evaluating local or whole-body bone density using a bioimpedance vector analysis technique only requires obtaining the height, resistance and reactance of the subject, and obtaining the first value and the second value, and then comparing the bioimpedance vector analysis graph to evaluate the partial or whole-body bone density of the subject. Compared with the prior art, the present invention is low-cost, fast, and easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 is a flow chart of an embodiment of the present invention.

[0013] Figure 2 is a block diagram of an embodiment of the present invention.

[0014] Figure 3a This is a bioimpedance vector analysis diagram according to an embodiment of the present invention, showing that the bone density of the subjects is divided into six groups.

[0015] Figure 3b This is a bioimpedance vector analysis diagram according to an embodiment of the present invention, showing that the bone density of the lumbar spine of the subjects is divided into six groups.

[0016] Figure 3c This is a bioimpedance vector analysis diagram according to an embodiment of the present invention, showing that the bone density of the right upper limb of the test subject is divided into six groups.

[0017] Figure 4 This is a GLM regression analysis diagram of an embodiment of the present invention.

[0018] 10: Bioimpedance vector analysis technique for assessing local or whole-body bone density

[0019] 20: Bioimpedance meter

[0020] 21: Electrode Group

[0021] 23: Sensing electrode

[0022] 25: Current electrode DETAILED DESCRIPTION

[0023] In order to explain the technical features of the present invention in detail, the following embodiment is now described with reference to the attached Figure 1-4 The description is as follows, wherein: the method 10 of the present invention for evaluating local or whole body bone density using the bioimpedance vector analysis technology comprises (such as Figure 1 shown):

[0024] Step (a) measures the resistance (R) and reactance (Xc) of a subject by a bioimpedance meter 20, and obtains the height of the subject, then divides the height of the subject by the resistance to obtain a first value, and divides the height of the subject by the reactance to obtain a second value.

[0025] Step (b) compares the first value and the second value with a bioimpedance vector analysis diagram, thereby evaluating the local or whole body bone density of the subject.

[0026] In this embodiment, the height of the subject is measured by a height ruler and then manually input into the bioimpedance measuring instrument 20, and the accuracy of the height ruler is taken to 0.5 cm (but not limited thereto), so that the height that best matches the current situation of the subject can be obtained to improve the accuracy of the evaluation result of the present invention. In other preferred embodiments, other instruments that can measure the resistance and reactance of the subject can also be used for measurement, and the subject can directly provide his height, and transmit it to the bioimpedance measuring instrument 20 in an automatic and wired / wireless manner, so the selection of the bioimpedance measuring instrument 20 and the way in which the bioimpedance measuring instrument 20 obtains the height of the subject are not limited to this preferred embodiment.

[0027] In this preferred embodiment, the bioimpedance measuring instrument 20 obtains the whole body (BMD total ), lumbar spine (BMD LS ) and right upper limb (BMD right arm ), a total of three parts of resistance and reactance. In other preferred embodiments, the measurement parts of the subject can be increased or decreased according to demand, so the measurement parts of the subject are not limited to the preferred embodiment.

[0028] like Figure 2As shown, in this preferred embodiment, the bioimpedance meter 20 measures the resistance and reactance of the subject. The subject is in a supine position to perform the bioimpedance meter 20 measurement, thereby reducing the error of the evaluation. The bioimpedance meter 20 has a plurality of electrode groups 21, the number of which is two for example. The plurality of electrode groups 21 contact the right hand and right foot of the subject to form a measurement circuit. Each of the electrode groups 21 has a sensing electrode 23 and a current electrode 25. The sensing electrode 23 and the current electrode 25 are 5 cm apart. Based on the characteristics of the bioimpedance measurement, the accuracy of the evaluation of the present invention can be improved. In other preferred embodiments, the subject can also be measured by the bioimpedance meter 20 in a standing or sitting position, and the plurality of electrode groups 21 can also be measured by contacting the subject's hands, feet, right hand to left foot, left hand to right foot, left hand to left foot, etc., respectively. In addition, under different measurement modes, the number of the plurality of electrode groups 21 can also exceed two, and the sensing electrode 23 and the current electrode 25 can also be between 1-5 cm or 5-10. Therefore, the number of the plurality of electrode groups 21 and the way in which the subject's resistance and reactance are measured by the bioimpedance meter 20 are not limited to the present preferred embodiment.

[0029] like Figure 3a -c, the bioimpedance vector analysis diagram in this preferred embodiment is a diagram for measuring the whole body (such as Figure 3a ), lumbar spine (such as Figure 3b ) and right upper limb (such as Figure 3c ), the resistance and reactance of the three parts are calculated and the impedance (R 2 +Xc 2 ) 0.5 , respectively obtain the bone density of the whole body, lumbar spine, and right upper limb, and then divide the three parts into six groups (I, II, III, IV, V, VI) according to the measured bone density. In this way, the subject only needs to obtain the height, resistance, and reactance through the bioimpedance measuring instrument 20, and after obtaining the first value and the second value, the whole body, lumbar spine, and right upper limb of the subject correspond to Figure 3a , Figure 3b and Figure 3c , that is, it is possible to know which group the bone density of the subject's measured part belongs to, and then evaluate the subject's bone density. In other preferred embodiments, the test subject's measurement parts can be increased or decreased as needed, and the size of the bone density can be divided into more or fewer groups as needed. Therefore, the use of the bioimpedance vector analysis diagram is not limited to this preferred embodiment.

[0030] In order to verify the accuracy of the method of the present invention in assessing bone density, the whole body, lumbar spine and right upper limb of the above-mentioned subjects were measured by DXA, and the average value of the bone density was taken and compared with the average value of the bone density measured by the present invention. Figure 4 As shown in the figure, the weight coefficient and correlation corresponding to the generalized linear model regression analysis (GLM regression analysis) show that the values ​​of R / H and Xc / H of the subject are positively correlated with the values ​​of the whole body, lumbar spine and right upper limb of the subject measured by DXA.

[0031] In other preferred embodiments, to verify the accuracy of the present invention, the bioimpedance vector analysis diagram can also be obtained by measuring with instruments such as quantitative ultrasound, quantitative computed tomography or traditional X-ray examination. Therefore, the acquisition of the bioimpedance vector analysis diagram is not limited to this preferred embodiment.

[0032] Therefore, the method provided by the present invention for evaluating local or whole-body bone density by using a bioimpedance vector analysis technique only needs to obtain the height, resistance and reactance of the subject, and after obtaining the first value and the second value, the bone density of the subject can be evaluated by comparing the bioimpedance vector analysis graph. Compared with the prior art, the present invention is low-cost, fast, and easy to use.

[0033] In addition, the present invention provides a method for evaluating local or whole-body bone density using a bioimpedance vector analysis technique, such as obtaining the height, resistance, and reactance of a subject at different time points, and obtaining a first value and a second value at each time point, and then comparing the bioimpedance vector analysis graph to evaluate changes in the subject's bone density, which is also convenient to use.

[0034] The specific embodiments described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A method for evaluating local or whole body bone density using bioimpedance vector analysis technology, characterized in that: The following steps are involved: (a) measuring the resistance and reactance of a subject by a bioimpedance meter, obtaining the height of the subject, dividing the height of the subject by the resistance to obtain a first value, and dividing the height of the subject by the reactance to obtain a second value; (b) The first value and the second value are compared with a bioimpedance vector analysis diagram to evaluate the local or whole body bone density of the subject.

2. The method for evaluating local or whole body bone density using bioimpedance vector analysis technology according to claim 1, characterized in that: In step (a), the bioimpedance meter measures the resistance and reactance of the subject by placing a plurality of electrode groups of the bioimpedance meter in contact with the hands and feet, hands or feet of the subject to form a measurement circuit, each of the electrode groups having a sensing electrode and a current electrode, and the sensing electrode and the current electrode are 1-10 cm apart.

3. The method for evaluating local or whole body bone density using bioimpedance vector analysis technology according to claim 1, characterized in that: In step (a), the subject is measured by the bioimpedance measuring instrument in a supine, standing or sitting position.

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