Drug release capsules

Abstract

The present invention discloses a drug-releasing capsule, comprising: a shell formed with an inner cavity, a drug-releasing shrapnel arranged in the inner cavity, and a control mechanism, wherein the shell has a drug-releasing port connecting the inner and outer cavity, and the drug-releasing shrapnel is provided with a drug-releasing portion opposite to the drug-releasing port; wherein the drug-releasing shrapnel has an initial state and a drug-releasing state, and in the initial state, the drug-releasing portion of the drug-releasing shrapnel is protruded in a direction away from the drug-releasing port; in the drug-releasing state, the drug-releasing shrapnel is deformed under the action of the control mechanism so that the drug-releasing portion moves toward the drug-releasing port. The present invention drives the drug to be released from the drug-releasing port through the driving force generated by the drug-releasing shrapnel during the deformation process, which is convenient for control, and the shrapnel can play a catapulting role on the drug, so that the drug has a greater initial velocity at the moment of ejection, and the drug-releasing efficiency is higher, and if the drug to be released is a drug-containing microneedle, the drug can be deeply inserted into the subcutaneous part of the lesion area after release, so that the drug administration effect is better.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, in particular to a drug-releasing capsule. Background Art

[0002] The controlled release of drugs can improve the therapeutic effect of drugs and reduce side effects, especially for the difficult-to-reach sections of the digestive tract. The use of capsule drug delivery has received more and more attention. It has the advantages of being non-destructive, painless, having a wide coverage range, and precise drug release.

[0003] At present, there are some design schemes for drug release capsules. Generally, a soft capsule is arranged inside the capsule, and the soft capsule is used to store drugs. At the same time, the soft capsule is placed in the inner cavity of the shell. During the drug release process, pressurized gas is released into the inner cavity to change the air pressure of the inner cavity. The increase in the air pressure of the inner cavity compresses the soft capsule, thereby achieving drug delivery. In the existing scheme, the drug wrapped in the soft capsule is squeezed out mainly by controlling the change of the pressure difference between the inside and outside of the soft capsule. This drug release method has low drug release efficiency. Summary of the invention

[0004] The object of the present invention is to provide a drug-releasing capsule which can eject drugs by means of shrapnel, so that the initial velocity of the drugs at the moment of ejection is greater and the drug-releasing efficiency is higher.

[0005] The drug-releasing capsule provided by the present invention comprises: a shell having an inner cavity, a drug-releasing spring arranged in the inner cavity, and a control mechanism, wherein the shell has a drug-releasing opening communicating with the inner and outer cavity, and the drug-releasing spring is provided with a drug-releasing portion opposite to the drug-releasing opening;

[0006] Among them, the drug releasing spring has an initial state and a drug releasing state. In the initial state, the drug releasing portion of the drug releasing spring is protruded in the direction away from the drug releasing port; in the drug releasing state, the drug releasing spring is deformed under the action of the control mechanism so that the drug releasing portion moves in the direction close to the drug releasing port.

[0007] Furthermore, the drug releasing spring has a spring body, both ends of which are respectively fixed on the shell, and in an initial state, the spring body is arched in a direction away from the drug releasing port and is located at a first bending position; in a drug releasing state, the spring body is arched in the direction of the drug releasing port and is located at a second bending position, and the drug releasing portion is arranged on the spring body.

[0008] Further, the shell has a columnar structure and includes a top wall, a bottom wall and a side wall connecting the top wall and the bottom wall which are arranged opposite to each other along the axial direction of the shell, and the drug release port is arranged on the side wall of the shell;

[0009] Two ends of the spring body are respectively fixed on the top wall and the side wall, and a gap is formed between the spring body and the shell in an initial state.

[0010] Furthermore, a mounting portion protruding toward the inner cavity is provided on the side wall of the shell, and the first end of the spring body is fixed on the mounting portion;

[0011] The top wall is provided with a top mounting portion protruding toward the inner cavity, and the second end of the spring body is fixed on the top mounting portion. After the spring body is fixed, the distance between the second end of the spring body and the plane where the drug release port is located is greater than the distance between the first end of the spring body and the plane where the drug release port is located.

[0012] Furthermore, in the initial state, the spring body has a first curved piece and a second curved piece, and the first curved piece and the second curved piece are both bent away from the drug release port to generate elastic deformation, and the drug release portion is arranged at the junction of the first curved piece and the second curved piece.

[0013] Another embodiment of the present invention further discloses a drug-releasing capsule, comprising: a shell having an inner cavity, a drug-releasing spring disposed in the inner cavity, and a control mechanism, wherein the shell has a drug-releasing port communicating with the inner and outer portions of the inner cavity;

[0014] The drug-releasing spring has an initial state and a drug-releasing state. In the initial state, the drug-releasing spring has a first curved piece that is bent in a direction away from the drug-releasing opening and elastically deformed, and a drug-releasing portion is formed on the first curved piece at a position opposite to the drug-releasing opening.

[0015] In the drug releasing state, the first curved piece is reset and swung under the action of the control mechanism to make the drug releasing portion move toward the direction close to the drug releasing port.

[0016] Furthermore, the drug-releasing spring has a second curved piece. In an initial state, the second curved piece cooperates with the first curved piece to limit the resetting swing of the drug-releasing spring.

[0017] Furthermore, in the initial state, the second bending piece bends in a direction away from the drug release port and produces elastic deformation, and the second bending piece and the first bending piece squeeze each other to form an arch at the joint away from the drug release port; in the drug release state, the second bending piece is reset and swung synchronously with the drug release spring.

[0018] Furthermore, the control mechanism includes a pushing member and a driving assembly for driving the pushing member to move, wherein the pushing member is arranged on a side of the drug releasing spring away from the drug releasing port, and drives the drug releasing spring to move and deform during the movement of the pushing member.

[0019] Further, the driving assembly includes a compression spring disposed in the inner cavity, the compression spring having a spring fixing end for fixing the compression spring and an extension end disposed opposite to the spring fixing end, and the pushing member is fixed on the extension end;

[0020] The compression spring has a compressed state and an extended state. In the compressed state, the compression spring is compressed and accumulates resilience. In the extended state, the accumulated resilience of the compression spring is released and drives the extended end to move in a direction away from the spring fixed end.

[0021] Furthermore, the control mechanism also includes a compression second bending piece and a compression release piece for maintaining the compression spring in a compressed state, the compression second bending piece includes a fusible wire, the compression release piece is used to heat the fusible wire and melt the fusible wire, and the fusible wire cooperates with the extension end before melting to limit the movement of the extension end.

[0022] Furthermore, the drive assembly includes an elastically deformable chamber body having a gas cavity and an air inlet channel connected to the gas cavity; the gas cavity is used to accommodate pressurized gas, and the elastically deformable chamber body is configured to expand and stretch under the action of the pressurized gas to drive the pushing member to move toward the direction close to the drug release spring.

[0023] Furthermore, an air storage chamber is formed in the shell, the air intake passage is communicated with the air storage chamber, and the drive assembly also has a valve body assembly for controlling the opening or closing of the air intake passage.

[0024] Furthermore, the valve body assembly includes a hot-melt film for blocking the air inlet passage and a film heating element for heating the hot-melt film.

[0025] Furthermore, the moving direction of the pushing member is perpendicular to the opening direction of the drug releasing port; the drug releasing port is opened along the radial direction of the drug releasing capsule, and the pushing member moves along the axial direction of the drug releasing capsule.

[0026] Furthermore, the shell is provided with a plurality of drug release ports, each of which is provided with a corresponding drug release spring, the control mechanism controls the plurality of drug release springs simultaneously, and the plurality of drug release ports are arranged in a ring shape along the circumference of the drug release capsule.

[0027] Furthermore, the shell is also provided with an ejection guide portion, which is arranged in the inner cavity and located at the edge of the drug release port, and a drug release channel is formed in the middle of the ejection guide portion opposite to the drug release port.

[0028] Furthermore, a gap portion for storing the substance to be released is formed between the exit guide portion and the drug releasing spring, and the drug releasing capsule also has drug-containing microneedles arranged in the gap portion, part of the drug-containing microneedles extend in the drug exit channel, and the drug-containing microneedles are opposite to the drug releasing portion.

[0029] Furthermore, the drug-releasing capsule also has a protective film for sealing the drug-releasing port, and the protective film is a biocompatible component.

[0030] Furthermore, the drug-releasing capsule also has an endoscope mechanism disposed in the inner cavity.

[0031] The beneficial effects of the present invention are: the driving force generated by the drug-releasing shrapnel during the deformation process drives the drug to be released from the drug release port, which is convenient for control, and the shrapnel can play a catapulting role on the drug, so that the initial velocity of the drug at the moment of ejection is greater, and the drug release efficiency is higher. If the drug to be released is a drug-containing microneedle, the drug can be deeply inserted into the subcutaneous tissue of the lesion area after release, so that the drug administration effect is better. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a schematic structural diagram of the first drug-releasing capsule disclosed in an embodiment of the present invention before drug release;

[0033] Figure 2 It is a schematic structural diagram of the first drug-releasing capsule in the drug-releasing process disclosed in an embodiment of the present invention;

[0034] Figure 3 It is a schematic diagram of the deformation process of the drug-releasing spring of the drug-releasing capsule disclosed in an embodiment of the present invention from a first bending position to a second bending position;

[0035] Figure 4 It is a schematic structural diagram of a drug-releasing capsule disclosed in an embodiment of the present invention, which is provided with multiple groups of drug-releasing ports;

[0036] Figure 5 It is a schematic diagram of the internal loading structure of the drug-releasing capsule disclosed in the embodiment of the present invention, which is provided with multiple groups of drug-releasing ports;

[0037] Figure 6 is a schematic structural diagram of the second drug-releasing capsule disclosed in an embodiment of the present invention before drug release;

[0038] Figure 7 It is a structural schematic diagram of a valve body assembly in a second drug-releasing capsule disclosed in an embodiment of the present invention;

[0039] Description of reference numerals: 1-shell, 10-inner cavity, 101-top wall, 102-bottom wall, 103-side wall, 11-drug release port, 12-emission guide portion, 120-emission channel, 13-gap space, 14-gas storage cavity, 15-installation portion, 16-top installation portion,

[0040] 2-drug-releasing shrapnel, 21-first curved piece, 22-second curved piece,

[0041] 3-control mechanism, 31-pushing member, 32-driving assembly, 320-gas chamber, 321-compression spring, 3211-spring fixing end, 3212-stretching end, 322-compression second bending piece, 323-compression release member, 324-elastically deformable chamber, 325-air inlet channel, 326-valve body assembly, 3261-hot-melt film, 3262-film heating element, 327-waterproof film,

[0042] 4-Medicated microneedles, 5-Endoscope mechanism,

[0043] 100-first bending position, 200-second bending position. DETAILED DESCRIPTION

[0044] The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, but should not be construed as limiting the present invention.

[0045] The embodiment of the present invention discloses a drug-releasing capsule, wherein the drug-releasing capsule stores a drug, and the drug is stored in the drug-releasing capsule and enters the drug-releasing area with the drug-releasing capsule, and is released when reaching the drug-releasing area, i.e., the lesion area. After entering the lesion area, the drug-releasing outlet is aligned with the lesion, so that the drug is ejected from the drug-releasing capsule and sprayed on the lesion, thereby achieving accurate drug delivery.

[0046] like Figure 1-5 As shown, the drug-releasing capsule disclosed in this embodiment comprises: a shell 1 formed with an inner cavity 10, a drug-releasing spring 2 disposed in the inner cavity 10, and a control mechanism 3, wherein the shell 1 has a drug-releasing opening 11 communicating with the inner and outer portions of the inner cavity 10, and the drug-releasing spring 2 is provided with a drug-releasing portion opposite to the drug-releasing opening 11;

[0047] Among them, the drug releasing spring 2 has an initial state and a drug releasing state. In the initial state, the drug releasing portion of the drug releasing spring 2 protrudes in the direction away from the drug releasing port; in the drug releasing state, the drug releasing spring 2 is deformed under the action of the control mechanism so that the drug releasing portion moves in the direction close to the drug releasing port.

[0048] In the use state, the medicine to be released is placed in the inner cavity. It should be noted that in the present embodiment, before the medicine is released, the medicine is placed on the moving track of the medicine releasing part when it moves in the medicine releasing state, and the object to be released is opposite to the position of the medicine releasing port 11. Therefore, in the medicine releasing state, the control mechanism drives the medicine releasing spring 2 to deform, and drives the medicine releasing part to move toward the medicine releasing port during the deformation of the medicine releasing spring 2, and drives the medicine releasing part to release from the medicine releasing port during the movement.

[0049] In this embodiment, the drug is released from the drug release port by the driving force generated by the drug release spring during the deformation process, which is convenient for control. The spring can also eject the drug, so that the initial velocity of the drug at the moment of ejection is greater and the drug release efficiency is higher. If the drug to be released is a drug-containing microneedle, the drug can be deeply inserted into the subcutaneous part of the lesion area after release, so that the drug administration effect is better.

[0050] During use, some drugs, such as some macromolecular drugs, can only be injected subcutaneously due to the characteristics of their biochemical composition. These macromolecular drugs can be made into drug-containing microneedles through soluble films and then taken orally using drug-release capsule technology. The drugs are then ejected by drug-release shrapnel and injected under the mucosa of the digestive tract, which can protect the drugs from being damaged by the enzyme environment in the digestive tract, achieving an effect similar to subcutaneous injection and improving patient compliance.

[0051] In this embodiment, the drug releasing spring 2 has a spring body, both ends of which are respectively fixed on the shell 1, and both ends of the spring body are respectively fixed on the shell 1. In the initial state, the spring body is arched in the direction away from the drug releasing port 11 and is located at the first bending position 100; in the drug releasing state, the spring body is arched in the direction toward the drug releasing port 11 and is located at the second bending position 200, and the drug releasing portion is arranged on the spring body.

[0052] The control mechanism 3 drives the spring body to deform and move from the first bending position 100 to the second bending position 200. During the movement of the spring body, the drug release portion arranged on the spring body moves toward the drug release opening 11 and drives the drug to be released to be released from the drug release opening 11 during the movement.

[0053] The housing 1 has a columnar structure and includes a top wall 101, a bottom wall 102 and a side wall 103 connecting the top wall and the bottom wall, which are arranged opposite to each other in the axial direction of the housing 1. The drug release port 11 is arranged on the side wall 103 of the housing 1.

[0054] The two ends of the spring body are respectively fixed on the top wall 101 and the side wall 103, and in the initial state, a gap is formed between the spring body and the housing 1. The gap space forms a space between the spring body and the side wall 103 of the housing 1, and the space can provide a movable space for the spring body when it bends to the second bending position.

[0055] Specifically, a mounting portion 15 protruding toward the inner cavity is provided on the side wall 103 of the housing 1, and the first end of the spring body is fixed on the mounting portion 15;

[0056] like Figure 1 As shown, the top wall 101 is provided with a top mounting portion 16 protruding into the inner cavity, and the second end of the spring body is fixed on the top mounting portion 16. After the spring body is fixed, the distance L2 between the second end of the spring body and the plane where the drug release port 11 is located is greater than the distance L1 between the first end of the spring body and the plane where the drug release port 11 is located.

[0057] By providing the top mounting portion 16 and the mounting portion 15, the installation and fixation of the spring body can be easily achieved. Moreover, since the mounting portion 15 and the top mounting portion 16 both protrude from the inner wall of the shell 1 to the inner cavity, the gap space formed between the spring body 2 and the shell 1 after installation and fixation is large enough, thereby avoiding interference of the shell 1 in the deformation process of the spring body, thereby affecting the activity of the spring body.

[0058] The mounting portion 15 and the top mounting portion 16 may both be mounting posts or mounting blocks disposed on the inner side wall of the housing 1 .

[0059] Furthermore, in order to better realize the ejection release of the drug, in the initial state, the spring body has a first bending piece 21 and a second bending piece 22, the first bending piece 21 and the second bending piece 22 are integrally formed, and the first bending portion 21 and the second bending portion 22 can be formed by bending a spring.

[0060] The drug release portion is arranged at the junction of the first curved piece 21 and the second curved piece 22, and the first curved piece 21 and the second curved piece 22 are both bent in the direction away from the drug release port 11 to generate elastic deformation, and the first curved piece 21 and the second curved piece 22 squeeze each other and generate a force that mutually restricts the restoration of their respective elastic deformations.

[0061] In the present embodiment, the first curved piece 21 and the second curved piece 22 constituting the drug-releasing spring piece 2 are both bent and elastically deformed in the initial state, and the first curved piece 21 and the second curved piece 22 are both stored with a rebound force, which can drive the drug-releasing portion at the junction of the first curved piece 21 and the second curved piece 22 to move toward the drug-releasing port 11. Thus, when the control mechanism 3 pushes the drug-releasing spring piece 2 to deform, the rebound force stored in the first curved piece 21 and the second curved piece 22 also acts on the drug and drives the drug to be released, so that the drug has a sufficiently large initial velocity in the initial stage of release, and the drug is more efficient during the release process.

[0062] Of course, in another embodiment, the first curved piece 21 and the second curved piece 22 may not produce elastic deformation, that is, no rebound force is accumulated, and the drug releasing spring 2 is simply a spring that is arched in the direction away from the drug releasing port. After the spring is subjected to a force on the side away from the drug releasing port, the spring is deformed to move the drug releasing portion toward the drug releasing port 11. After being pushed, the spring is deformed and arched in the opposite direction, and in the process promotes the release of the drug.

[0063] In this embodiment, in order to better realize the effect on the drug releasing spring 2, the control mechanism 3 includes a pushing member 31 and a driving component 32 for driving the pushing member 31 to move. The pushing member 31 is arranged on the side of the drug releasing spring 2 away from the drug releasing port 11. The pushing member 31 pushes the drug releasing spring 2 to move and deform during the movement.

[0064] In a specific embodiment, the driving assembly 32 includes a compression spring 321 disposed in the inner cavity, the compression spring 321 having a spring fixing end 3211 for fixing the compression spring 321 and an extension end 3212 disposed opposite to the spring fixing end 3211, and the pushing member 31 is fixed on the extension end 3212; in this embodiment, the spring fixing end 3211 is fixed on the housing 1;

[0065] The compression spring 321 has a compressed state and an extended state. In the compressed state, the compression spring 321 is compressed and accumulates resilience. In the extended state, the resilience accumulated by the compression spring 321 is released and drives the extended end 3212 to move away from the spring fixed end 3211.

[0066] The compression spring 321 is pre-compressed to accumulate resilience. When releasing the drug, the accumulated resilience of the compression spring 321 is controlled to be released so as to drive the pusher 31. The pusher 31 pushes and deforms the drug-releasing spring 2 during the movement.

[0067] In order to better control the release of the drug, the control mechanism 3 further comprises a compression second curved piece 322 and a compression release member 323. The compression second curved piece 322 is used to control the compression spring 321 to maintain in a compressed state.

[0068] The compressed second bending piece 322 includes a fusible wire, and the compressed release piece 323 is used to heat the fusible wire and blow the fusible wire. Before blowing, the fusible wire cooperates with the extension end 3212 to limit the movement of the extension end 3212. The fusible wire has a low melting point, such as nylon, low melting point metal, etc., and softens quickly when heated.

[0069] When the compression spring 321 is in a compressed state, one end of the fusible wire can be connected and fixed to the extension end 3212, and the other end of the fusible wire can be fixed to the spring fixing end 3211, or the other end of the fusible wire can be directly fixed to the housing 1. The fusible wire pulls the extension end 3212, and the pulling force of the fusible wire on the extension end 3212 is opposite to the direction of the resetting resilience force of the compression spring 321 on the extension end 3212.

[0070] When the resilience accumulated by the compression spring 321 is released, it is only necessary to cancel the pulling force of the fusible wire on the extension end 3212. In order to facilitate the control, the present embodiment heats the fusible wire by compressing the release member 323 to melt the fusible wire.

[0071] Specifically, the compression release member 323 includes a heating wire arranged beside the fusible wire and an electric control unit connected and fixed to the heating wire, the electric control unit is used to control the heating wire to heat, and the heating wire heats the fusible wire so that the fusible wire melts. The electric control unit is arranged in the housing 1, and the release of the spring accumulated resilience can be achieved more conveniently through the cooperation of the heating component and the fusible wire.

[0072] In another embodiment, in order to better control the fusible wire, the fusible wire is directly connected and fixed to the compression release member 323, and the compression release member 323 is fixed to the housing, so that during the heating process, heat can be directly released to the fusible wire, thereby achieving melting of the fusible wire. The compression release member 323 can be a heating wire or a heating disk.

[0073] It is understandable that in order to prevent the fuse and the related electronic control unit from being affected by digestive fluid, etc., the compression spring 321 is also coated with a waterproof membrane 327, and the waterproof membrane 327 can be set to be retractable. When the compression spring 321 is stretched, the waterproof membrane 327 also expands and stretches synchronously. Of course, in another embodiment, the length of the waterproof membrane 327 is set to be not less than the height of the compression spring after stretching, so that a good waterproof effect can still be achieved after the compression spring is stretched.

[0074] The pushing member 31 can move along the opening direction of the drug release port to push the drug release spring 2. In this case, the drug is actually released under the dual elastic force of the compression spring 321 and the drug release spring 2. The rebound force of the compression spring 321 acts on the drug release spring 2, and the drug release spring 2 is deformed again to achieve the release of the drug. This method can make the drug have a higher initial velocity at the moment of release, thereby better achieving the release of the drug.

[0075] In this embodiment, the drug releasing capsule is cylindrical in shape and has an axial direction, and the cross section of the drug releasing capsule is circular. The moving direction of the pushing member 31 is perpendicular to the opening direction of the drug releasing port 11; the drug releasing port 11 opens along the radial direction of the drug releasing capsule, and the pushing member 31 moves along the axial direction of the drug releasing capsule.

[0076] Correspondingly, the stretching direction of the compression spring 321 during the stretching process is along the axial direction of the drug releasing capsule. In this embodiment, the drug release is achieved through the cooperation of the compression spring 321 and the drug releasing shrapnel 2. The setting of the drug releasing shrapnel 2 converts the thrust of the compression spring 321 in the axial direction into the elastic force for releasing the drug in the radial direction, so that the drug release time is shorter and the initial velocity is greater during the release process, and the control of drug release is also more convenient.

[0077] In this embodiment, the shell 1 is provided with a plurality of drug release ports 11, each of which is provided with a corresponding drug release spring 2. The plurality of drug release ports 11 can enable the drug release capsule to release drugs at multiple locations at the same time and in multiple directions.

[0078] In order to better control the multiple drug-releasing shrapnels 2, the pusher 31 in the control mechanism 3 that drives the drug-releasing shrapnel 2 to deform is arranged to move along the axial direction of the drug-releasing capsule, and the drug-releasing shrapnel 2 moves along the radial direction of the drug-releasing capsule when ejecting the drug to release the drug. Therefore, it is possible to achieve that the control mechanism 3 controls the multiple drug-releasing shrapnels 2 to deform simultaneously and push the drug to be released.

[0079] Furthermore, the plurality of drug release openings 11 are arranged in a ring shape along the circumference of the drug release capsule. The drug release openings 11 are arranged in a ring shape along the circumference of the drug release capsule so that the heights of the drug release openings 11 in the axial direction are consistent, so that when the pusher 31 moves in the vertical direction, it can act on all drug release springs 2 at the same time, thereby achieving synchronization of drug release.

[0080] In addition, since the drug release opening 11 is arranged in the circumferential direction of the drug release capsule, the drug release capsule can release drugs in multiple directions. Multiple different types of drugs can be stored in one drug release capsule, so that one drug release capsule can release multiple drugs.

[0081] Furthermore, in order to better control the direction of drug release in this embodiment, an exit guide portion 12 is also provided on the shell. The exit guide portion 12 is arranged in the inner cavity 10 and is located at the edge of the drug release port 11. A drug outlet channel 120 is formed in the middle of the exit guide portion 12 opposite to the drug release port 11.

[0082] The ejection guide 12 is used to guide the drug during its ejection process, to prevent the drug from deviating from the drug release port 11 before exiting the inner cavity 10 , and to allow the drug to move along the drug outlet channel 120 before reaching the drug release port 11 .

[0083] In this embodiment, a gap portion for storing the substance to be released is formed between the exit guide portion 12 and the two drug releasing springs. The drug releasing capsule also has a drug-containing microneedle 4 arranged in the gap portion 13. Part of the drug-containing microneedle 4 extends in the drug outlet channel 120, and the drug-containing microneedle 4 is opposite to the drug releasing portion.

[0084] In this embodiment, drug-containing microneedles 4 are used to load drugs, and the drug-releasing shrapnel 2 ejects the drug-containing microneedles 4 from the drug-releasing port 11. The drug-containing microneedles 4 can be inserted into the subcutaneous tissue after being ejected at a relatively large initial velocity. The drug-containing microneedles 4 are wrapped with a layer of soluble film. After the drug-containing microneedles 4 are injected into the subcutaneous tissue, the film wrapping the drug melts, thereby achieving subcutaneous drug administration.

[0085] Pre-positioning the drug-containing microneedle 4 in the gap 13 and extending part of the drug-containing microneedle 4 in the drug outlet channel 120 can effectively guide the drug-containing microneedle 4 during the drug release process. It is understandable that the drug-containing microneedle 4 is opposite to the drug release portion, so that it can be easily ejected by the drug release shrapnel.

[0086] The drug-containing microneedles 4 can also be loaded during use. Specifically, when in use, first obtain a drug-releasing capsule, then load the drug-containing microneedles 4 into the gap 13 of the drug-releasing capsule, and after loading, send the drug-releasing capsule into the intestine to release the drug.

[0087] After the drug-containing microneedles 4 are loaded, the drug-releasing capsule also has a protective film for blocking the drug-releasing opening 11, and the protective film is a biocompatible component. Covering the drug-releasing opening 11 with a layer of biocompatible film can effectively protect the drug.

[0088] In this embodiment, the heating element is controlled to melt the fusible wire, and the rebound force accumulated in the compression spring is released at the moment when the fusible wire is blown. When released, the compression spring drives the pusher to move and acts on the drug releasing spring 2, so that the spring originally protruding away from the drug releasing port 11 is deformed and protruded toward the drug releasing port 11, so that the drug releasing part on the drug releasing spring 2 moves from a position away from the drug releasing port 11 to the drug releasing port 11, and the drug is released during the movement. Moreover, since the spring used has a reset rebound force, the drug is ejected by the elastic force of the spring at the moment of release, so that the drug has a larger initial velocity at the moment of release, which can make the drug-containing microneedle penetrate into the subcutaneous tissue after being ejected from the drug releasing capsule, thereby better achieving drug administration.

[0089] In this embodiment, the drug-releasing capsule further comprises an endoscope mechanism 5 disposed in the inner cavity, and the endoscope mechanism 5 can obtain image information outside the drug-releasing capsule, thereby achieving accurate drug administration.

[0090] It can be understood that the endoscope mechanism 5 includes a camera module, a power supply unit, a communication module and a control unit arranged in the housing 1. In order to conveniently obtain image information outside the drug-releasing capsule, the housing 1 is set as a transparent body, the power supply unit supplies power to the camera module, the communication module and the control unit, the communication module is used to establish communication with the outside world to facilitate the control of the drug-releasing capsule, and the camera module is used to collect image information outside the capsule after entering the digestive tract. It should be noted that the specific working method of the specific endoscope mechanism 5 is a prior art and will not be repeated here.

[0091] In the above embodiment, a compression spring is used as the driving member to move. Figure 6-7 As shown, in another embodiment, the driving assembly 32 includes an elastically deformable chamber 324 having a gas chamber 320 and an air inlet channel 325 connected to the gas chamber 320; the gas chamber 320 is used to contain pressurized gas, and the elastically deformable chamber 324 is configured to expand and stretch under the action of the pressurized gas to drive the pusher 31 to move toward the direction close to the drug-releasing shrapnel 2. It can be understood that the pusher 31 is fixed on the elastically deformable chamber 324, so as to facilitate the pushing of the pusher 31 when the elastically deformable chamber 324 expands and stretches.

[0092] In the above embodiment, the pressurized gas can enter the gas chamber 320 through the air inlet channel 325. After entering the gas chamber 320, the pressurized gas can expand and stretch the elastically deformable chamber body 324, and drive the movement of the pusher 31 when the elastically deformable chamber body 324 expands and stretches. Therefore, the movement of the pusher 31 can be controlled by controlling the pressurized gas entering the gas chamber 30, thereby conveniently controlling the release of the drug by the drug-releasing shrapnel 2.

[0093] The housing 1 is formed with a gas storage chamber 14, the gas inlet passage 325 is in communication with the gas storage chamber 14, and the driving assembly 32 further comprises a valve assembly 326 for controlling the opening or closing of the gas inlet passage 325. The gas entering the gas chamber 320 can be pre-filled in the gas storage chamber 14 in the housing 1, and when the drug needs to be released, the valve assembly 326 is controlled to open the gas inlet passage 325, and the pressurized gas enters the gas chamber 320 from the gas outlet chamber 14, and then deforms the elastically deformable chamber body 324 and drives the pusher 31.

[0094] In order to facilitate control, the valve body assembly 326 includes a hot melt film 3261 for blocking the air inlet channel 325 and a film heating element 3262 for heating the hot melt film 3261. In the initial state, the hot melt film 3261 blocks the air inlet channel 325. In the drug release state, the hot melt film 3261 is heated and melted by the film heating element 3262 to achieve the conduction of the air inlet channel 325, so that the pressurized gas can flow from the air outlet cavity 14 to the gas cavity 320.

[0095] like Figure 1 The present invention discloses a drug-releasing capsule, comprising a shell 1 with an inner cavity 10, a drug-releasing shrapnel 2 disposed in the inner cavity 10, and a control mechanism 3. The shell 1 has a drug-releasing port 11 communicating with the inner and outer portions of the inner cavity 10.

[0096] The drug releasing spring 2 has an initial state and a drug releasing state. In the initial state, the drug releasing spring 2 has a first bending piece 21 that is bent in a direction away from the drug releasing opening 11 and generates elastic deformation. A drug releasing portion is formed on the first bending piece 21 at a position opposite to the drug releasing opening 11.

[0097] In the drug releasing state, the first curved piece 21 is reset and swung under the action of the control mechanism 3 so that the drug releasing portion moves toward the direction close to the drug releasing port 11 .

[0098] In this embodiment, the first bending piece 21 is pre-bent to accumulate resilience, and the medicine is released under the action of the restoring resilience of the elastic deformation.

[0099] It is understandable that in order to enable the drug releasing spring 2 to maintain elastic deformation in the initial state, the drug releasing capsule further has a second curved piece 22. In the initial state, the second curved piece 22 cooperates with the first curved piece 21 to limit the reset swing of the drug releasing spring 2.

[0100] In this embodiment, the second bending piece 22 is a spring piece connected and fixed to the first bending piece 21. In the initial state, the second bending piece 22 bends in the direction away from the drug release port 11 and produces elastic deformation. The second bending piece 22 and the drug release spring piece 2 squeeze each other to form an arch away from the drug release port 11 at the joint; in the drug release state, the second bending piece 22 resets and swings synchronously with the first bending piece 21.

[0101] The second curved piece 22 and the first curved piece 21 can be integrally formed, and are formed by bending a spring sheet. The first end of the first curved piece 21 is fixed to the housing 1, and the second end of the first curved piece 21 connected to the second curved piece 22 moves in a direction away from the drug release port 11 with the elastic deformation of the first curved piece 21 and moves in a direction close to the drug release port 11 with the reset swing of the first curved piece 21. The first end of the second curved piece 22 is fixed to the housing 1, and the second end of the second curved piece 22 is connected and fixed to the second end of the first curved piece 21. Since the second curved piece 22 is also an elastic spring sheet, it can be deformed with the deformation of the first curved piece 21, and the second end of the second curved piece 22 and the second end of the first curved piece 21 can move synchronously.

[0102] In the initial state, the second bending piece 22 and the first bending piece 21 are both bent and elastically deformed in the direction away from the drug release port 11. The second bending piece 22 and the first bending piece 21 are squeezed against each other to form a mutual restraint to avoid reset swinging. The second bending piece 22 can be regarded as a spring piece supported on the reset swinging path of the first bending piece 21.

[0103] In this embodiment, the second curved piece 22 swings synchronously with the first curved piece 21 when the first curved piece 21 is reset and swung. In other embodiments, the second curved piece 22 can also avoid the first curved piece 21 when the first curved piece 21 is reset and moved, so that the first curved piece 21 is unobstructed when it is reset and swung. In this case, the first curved piece 21 and the second curved piece 22 are split. In the initial state, the second curved piece 22 abuts against the first curved piece 21, so that the second curved piece 22 is supported between the first curved piece 21 and the housing 1. In the drug release state, the second curved piece 22 is separated from the first curved piece 21 and deviates from the reset movement track of the first curved piece 21.

[0104] It is understandable that the drive assembly 32 can adopt the structure of the above embodiment, which will not be described in detail. Under the driving action of the drive assembly 32, the balance between the first curved piece 21 and the second curved piece is broken, and after being broken, the first curved piece 21 can be reset and swung toward the direction of the drug release port 11.

[0105] The above describes in detail the structure, features and effects of the present invention based on the embodiments shown in the drawings. The above is only a preferred embodiment of the present invention, but the present invention is not limited to the scope of implementation shown in the drawings. Any changes made according to the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the description and drawings, should be within the protection scope of the present invention.

Claims

1. A drug-releasing capsule, characterized in that: include: A shell body having an inner cavity, a drug releasing spring sheet disposed in the inner cavity, and a control mechanism, wherein the shell body has a drug releasing port communicating with the inner and outer cavity, and the drug releasing spring sheet is provided with a drug releasing portion opposite to the drug releasing port; Among them, the drug releasing spring has an initial state and a drug releasing state. In the initial state, the drug releasing portion of the drug releasing spring is protruded in the direction away from the drug releasing port; in the drug releasing state, the drug releasing spring is deformed under the action of the control mechanism so that the drug releasing portion moves in the direction close to the drug releasing port.

2. The drug-releasing capsule according to claim 1, characterized in that: The drug releasing spring has a spring body, both ends of which are respectively fixed on the shell. In the initial state, the spring body is arched in the direction away from the drug releasing port and is located at a first bending position. In the drug releasing state, the spring body is arched in the direction of the drug releasing port and is located at a second bending position, and the drug releasing portion is arranged on the spring body.

3. The drug-releasing capsule according to claim 2, characterized in that: The shell has a columnar structure and includes a top wall, a bottom wall and a side wall connecting the top wall and the bottom wall which are arranged opposite to each other in the axial direction of the shell, and the drug release port is arranged on the side wall of the shell; Two ends of the spring body are respectively fixed on the top wall and the side wall, and a gap is formed between the spring body and the shell in an initial state.

4. The drug-releasing capsule according to claim 3, characterized in that: A mounting portion protruding toward the inner cavity is provided on the side wall of the shell, and the first end of the spring body is fixed on the mounting portion; The top wall is provided with a top mounting portion protruding toward the inner cavity, and the second end of the spring body is fixed on the top mounting portion. After the spring body is fixed, the distance between the second end of the spring body and the plane where the drug release port is located is greater than the distance between the first end of the spring body and the plane where the drug release port is located.

5. The drug-releasing capsule according to claim 2, characterized in that: In the initial state, the spring body has a first curved piece and a second curved piece, and the first curved piece and the second curved piece are both bent away from the drug release port to generate elastic deformation, and the drug release portion is arranged at the junction of the first curved piece and the second curved piece.

6. A drug-releasing capsule, characterized in that: include: A shell body having an inner cavity, a drug-releasing spring arranged in the inner cavity, and a control mechanism, wherein the shell body has a drug-releasing port communicating with the inner and outer portions of the inner cavity; The drug-releasing spring has an initial state and a drug-releasing state. In the initial state, the drug-releasing spring has a first curved piece that is bent in a direction away from the drug-releasing opening and elastically deformed, and a drug-releasing portion is formed on the first curved piece at a position opposite to the drug-releasing opening. In the drug releasing state, the first curved piece is reset and swung under the action of the control mechanism to make the drug releasing portion move toward the direction close to the drug releasing port.

7. The drug-releasing capsule according to claim 6, characterized in that: The drug-releasing spring piece also has a second curved piece. In an initial state, the second curved piece cooperates with the first curved piece to limit the resetting swing of the drug-releasing spring piece.

8. The drug-releasing capsule according to claim 7, characterized in that: In the initial state, the second bending piece bends in the direction away from the drug release port and produces elastic deformation, and the second bending piece and the first bending piece squeeze each other to form an arch away from the drug release port at the joint; in the drug release state, the second bending piece resets and swings synchronously with the drug release spring piece.

9. The drug-releasing capsule according to any one of claims 1 to 8, characterized in that: The control mechanism includes a pusher and a driving assembly for driving the pusher to move. The pusher is arranged on a side of the drug-releasing spring away from the drug-releasing port, and drives the drug-releasing spring to move and deform during the movement of the pusher.

10. The drug-releasing capsule according to claim 9, characterized in that: The driving assembly comprises a compression spring disposed in the inner cavity, the compression spring having a spring fixing end for fixing the compression spring and an extension end disposed opposite to the spring fixing end, and the pushing member is fixed on the extension end; The compression spring has a compressed state and an extended state. In the compressed state, the compression spring is compressed and accumulates resilience. In the extended state, the accumulated resilience of the compression spring is released and drives the extended end to move in a direction away from the spring fixed end.

11. The drug-releasing capsule according to claim 10, characterized in that: The control mechanism also includes a compression second bending piece and a compression release piece for maintaining the compression spring in a compressed state, the compression second bending piece includes a fusible wire, the compression release piece is used to heat the fusible wire and melt the fusible wire, and the fusible wire cooperates with the extension end before melting to limit the movement of the extension end.

12. The drug-releasing capsule according to claim 9, characterized in that: The drive assembly includes an elastically deformable chamber body having a gas cavity and an air inlet channel connected to the gas cavity; the gas cavity is used to accommodate pressurized gas, and the elastically deformable chamber body is configured to expand and stretch under the action of the pressurized gas to drive the pushing member to move toward the direction close to the drug release spring.

13. The drug-releasing capsule according to claim 12, characterized in that: An air storage chamber is formed in the shell, the air intake passage is communicated with the air storage chamber, and the drive assembly also has a valve body assembly for controlling the opening or closing of the air intake passage.

14. The drug-releasing capsule according to claim 13, characterized in that: The valve body assembly includes a hot-melt film for blocking the air inlet passage and a film heating element for heating the hot-melt film.

15. The drug-releasing capsule according to claim 9, characterized in that: The moving direction of the pushing member is perpendicular to the opening direction of the drug releasing port; the drug releasing port is opened along the radial direction of the drug releasing capsule, and the pushing member moves along the axial direction of the drug releasing capsule.

16. The drug-releasing capsule according to claim 15, characterized in that: The shell is provided with a plurality of drug release openings, each of which is provided with a corresponding drug release spring, the control mechanism controls the plurality of drug release springs simultaneously, and the plurality of drug release openings are arranged in a ring shape along the circumference of the drug release capsule.

17. The drug-releasing capsule according to any one of claims 1 to 8, characterized in that: The shell is also provided with an ejection guide part, which is arranged in the inner cavity and located at the edge of the drug release port, and a drug release channel is formed in the middle of the ejection guide part opposite to the drug release port.

18. The drug-releasing capsule according to claim 17, characterized in that: A gap portion for storing the substance to be released is formed between the exit guide portion and the drug releasing spring. The drug releasing capsule also has drug-containing microneedles arranged in the gap portion. Part of the drug-containing microneedles extends in the drug exit channel, and the drug-containing microneedles are opposite to the drug releasing portion.

19. The drug-releasing capsule according to claim 18, characterized in that: The drug-releasing capsule also has a protective film for sealing the drug-releasing port, and the protective film is a biocompatible component.

20. The drug-releasing capsule according to any one of claims 1 to 8, characterized in that: The drug-releasing capsule also has an endoscope mechanism disposed in the inner cavity.

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