Experimental processing methods, devices, controllers and storage media for immunoassay development

Abstract

The present application relates to the technical field of automated development of immune reagents, and provides an experimental processing method, device, controller, storage medium and program product for immune reagent development, which can reduce the number of reagent bottles used and save reagent components. In the present application, the reagent components contained in different reagent bottles are different in at least one of the type and formation method; the method includes: obtaining the target reagent ship number and the target slot order according to the corresponding relationship, the type of target immune reagent component forming the target immune reagent and the formation method; controlling the liquid extractor to move to the target reagent ship corresponding to the target reagent ship number, controlling the liquid extractor to move to the target slot of the target reagent ship that matches the target slot order, controlling the liquid extractor to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form the target immune reagent according to the obtained target immune reagent component, and conducting a development experiment for the target immune reagent.

Description

Technical Field

[0001] The present application relates to the technical field of automated development of immune reagents, and in particular to an experimental processing method, device, controller, storage medium and computer program product for immune reagent development. Background Art

[0002] The immunoassay development process requires the arrangement and combination of different types of reagent components with different formation methods to form an immunoassay, and then experiments on the formed immunoassay to complete the development of the immunoassay.

[0003] The arrangement and combination of immune reagents is related to the number of formation methods of reagent components and the types of reagent components. For example, if the number of formation methods of reagent components is 4 and the types of reagent components are 3, there are at least 4×3=12 arrangement and combination methods.

[0004] In the traditional reagent boat configuration method, the reagent components required to form each arrangement and combination are placed in different reagent bottles. According to this configuration method, if there are 12 arrangements and combinations, 12×3=36 reagent bottles are required. However, a small amount of reagent components in the reagent bottle cannot be taken out by the liquid extractor, and the reagent bottle has a dead space problem. Therefore, the more reagent bottles are used, the more reagent components are wasted. Summary of the invention

[0005] Based on this, it is necessary to provide an experimental processing method, device, controller, storage medium and computer program product for the development of immune reagents to address the above technical problems.

[0006] The present application provides an experimental processing method for developing an immunological reagent. When the same type of reagent components are formed in different ways or the types of the reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components in different reagent bottles are different in at least one of the type and the formation mode; the formation mode includes a formula and a preparation process; the method includes:

[0007] According to the development experimental task for the target immune reagent, determining the type and formation method of the target immune reagent components forming the target immune reagent;

[0008] Obtaining a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0009] According to the corresponding relationship, the type of target immune reagent component and the formation method, the target reagent ship number and the target slot order are obtained;

[0010] For the target reagent ship corresponding to the target reagent ship number, the liquid extractor is controlled to move to the target slot of the target reagent ship that matches the target slot sequence, and the liquid extractor is controlled to take out the target immune reagent component from the reagent bottle placed in the target slot to form the target immune reagent according to the obtained target immune reagent component, and a development experiment for the target immune reagent is carried out.

[0011] The present application provides an experimental processing device for developing immunological reagents. When the same type of reagent components are formed in different ways or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components loaded in different reagent bottles are different in at least one of the types and the formation methods. The device comprises:

[0012] A reagent component determination module, used to determine the type and formation method of the target immune reagent components forming the target immune reagent according to the development experiment task for the target immune reagent;

[0013] A correspondence acquisition module is used to acquire a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots containing the reagent bottle among the slots of the reagent ship; and the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0014] A positioning module, used to obtain the target reagent ship number and the target slot order according to the corresponding relationship, the type of the target immune reagent component and the formation method;

[0015] The control module is used to control the liquid extractor to move to the target slot of the target reagent ship corresponding to the target reagent ship number and to control the liquid extractor to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form the target immune reagent according to the obtained target immune reagent component, and to carry out the development experiment for the target immune reagent.

[0016] The present application provides a controller, including a memory and a processor, wherein the memory stores a computer program, and the processor executes the following steps:

[0017] According to the development experimental task for the target immune reagent, determining the type and formation method of the target immune reagent components forming the target immune reagent;

[0018] Obtaining a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0019] According to the corresponding relationship, the type of target immune reagent component and the formation method, the target reagent ship number and the target slot order are obtained;

[0020] For a target reagent ship corresponding to the target reagent ship number, control the liquid taker to move to a target slot of the target reagent ship that matches the sequence between the target slots, control the liquid taker to take out a target immune reagent component from a reagent bottle placed in the target slot, so as to form a target immune reagent according to the obtained target immune reagent component, and perform a development experiment for the target immune reagent;

[0021] When the same type of reagent components are formed in different ways or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles so that the reagent components in different reagent bottles are different in at least one of the types and the formation methods.

[0022] The present application provides a computer-readable storage medium having a computer program stored thereon, wherein the computer program is executed by a processor to perform the following steps:

[0023] According to the development experimental task for the target immune reagent, determining the type and formation method of the target immune reagent components forming the target immune reagent;

[0024] Obtaining a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0025] According to the corresponding relationship, the type of target immune reagent component and the formation method, the target reagent ship number and the target slot order are obtained;

[0026] For a target reagent ship corresponding to the target reagent ship number, control the liquid taker to move to a target slot of the target reagent ship that matches the sequence between the target slots, control the liquid taker to take out a target immune reagent component from a reagent bottle placed in the target slot, so as to form a target immune reagent according to the obtained target immune reagent component, and perform a development experiment for the target immune reagent;

[0027] When the same type of reagent components are formed in different ways or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles so that the reagent components in different reagent bottles are different in at least one of the types and the formation methods.

[0028] The present application provides a computer program product having a computer program stored thereon, wherein the computer program is executed by a processor to perform the following steps:

[0029] According to the development experimental task for the target immune reagent, determining the type and formation method of the target immune reagent components forming the target immune reagent;

[0030] Obtaining a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0031] According to the corresponding relationship, the type of target immune reagent component and the formation method, the target reagent ship number and the target slot order are obtained;

[0032] For a target reagent ship corresponding to the target reagent ship number, control the liquid taker to move to a target slot of the target reagent ship that matches the sequence between the target slots, control the liquid taker to take out a target immune reagent component from a reagent bottle placed in the target slot, so as to form a target immune reagent according to the obtained target immune reagent component, and perform a development experiment for the target immune reagent;

[0033] When the same type of reagent components are formed in different ways or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles so that the reagent components in different reagent bottles are different in at least one of the types and the formation methods.

[0034] In the present application, when the formation methods of reagent components of the same type are different, or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components in different reagent bottles are different in at least one of the types and formation methods. In this way, in the case of multiple permutations and combinations, the number of reagent bottles used can be reduced and reagent components can be saved; on the basis that the reagent components in different reagent bottles are different in at least one of the types and formation methods, according to the development experimental tasks for the target immune reagent, the type and formation method of the target immune reagent components that form the target immune reagent are determined, and then according to the correspondence between the pre-constructed first information and the second information, The type and formation method of the target immune reagent component are obtained, and the target reagent ship number and the target slot order are obtained; wherein, the first information includes: the reagent ship number where the reagent bottle is located and the slot order of the slot containing the reagent bottle in the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle; for the target reagent ship corresponding to the target reagent ship number, the liquid extractor is controlled to move to the target slot of the target reagent ship that matches the target slot order, and the liquid extractor is controlled to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form the target immune reagent according to the obtained target immune reagent component, and carry out development experiments for the target immune reagent, so as to realize automated development experiments and improve efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 is a schematic diagram of a reagent boat in one embodiment;

[0036] Figure 2 A schematic diagram of a process flow diagram of an experimental processing method developed for an immunological reagent in one embodiment;

[0037] Figure 3 The relative positions of the reagent turntable, the reagent boat and the liquid extraction point in one embodiment are shown;

[0038] Figure 4 A block diagram of the experimental processing device developed for an immunological reagent in one embodiment;

[0039] Figure 5 FIG. 4 is a diagram showing the internal structure of a controller in one embodiment. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0041] Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described in this application may be combined with other embodiments.

[0042] In the experimental processing method for the development of immunological reagents provided in the present application, when the formation methods of reagent components of the same type are different, or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components loaded in different reagent bottles are different in at least one of the types and formation methods. Among them, the formation method includes the formula and the preparation process. The reagent components are divided into types, including: magnetic bead antibodies, blocking agents, marker antibodies and biotin antibodies.

[0043] Taking the reagent components including: magnetic bead antibodies, blocking agents, marker antibodies and biotin antibodies, and the formation methods are 2 as an example, based on the number of types of reagent components and the number of formation methods, there are 8 permutations and combinations, each of which requires 4 reagent bottles, so 32 reagent bottles are required. If the method provided in this application is followed, only 8 reagent bottles are required, such as Figure 1As shown, the reagent boat 101 holds 4 reagent bottles, and the reagent boat 102 holds 4 reagent bottles. The reagent components in each reagent bottle are different in at least one of the type and the formation method. For example, magnetic bead antibody 1 and magnetic bead antibody 2 are of the same type, but are from different manufacturers and have different formation methods. Another example is magnetic bead antibody 1 and blocking agent 1. Although they are from the same manufacturer, they are of different types. In this way, the number of reagent bottles used is reduced and the amount of reagent components wasted is reduced.

[0044] The method provided in this application can be executed by a controller, such as Figure 2 As shown, the method comprises the following steps:

[0045] Step S201, according to the development experiment task for the target immune reagent, determine the type and formation method of the target immune reagent components forming the target immune reagent.

[0046] Step S202, obtaining the correspondence between the pre-constructed first information and the second information.

[0047] The first information includes: the reagent ship number where the reagent bottle is located and the order of the slots containing the reagent bottle among the slots in the reagent ship; the second information includes: the type and formation method of the reagent component contained in the reagent bottle.

[0048] The order of the slot among the slots of the reagent ship is used to indicate which slot the slot is in the reagent ship.

[0049] Step S203, obtaining the target reagent ship number and the target slot order according to the corresponding relationship, the type of the target immune reagent component and the formation method.

[0050] Step S204, for the target reagent ship corresponding to the target reagent ship number, control the liquid extractor to move to the target slot of the target reagent ship that matches the target slot sequence, control the liquid extractor to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form a target immune reagent according to the obtained target immune reagent component, and conduct a development experiment for the target immune reagent.

[0051] In the present application, when the formation methods of reagent components of the same type are different, or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components in different reagent bottles are different in at least one of the types and formation methods. In this way, in the case of multiple permutations and combinations, the number of reagent bottles used can be reduced and reagent components can be saved; on the basis that the reagent components in different reagent bottles are different in at least one of the types and formation methods, according to the development experimental task for the target immune reagent, the type and formation method of the target immune reagent components that form the target immune reagent are determined, and then according to the correspondence between the pre-constructed first information and the second information, the target immune reagent is determined. The type and formation method of the immune reagent component are obtained to obtain the target reagent ship number and the target slot order; wherein, the first information includes: the reagent ship number where the reagent bottle is located and the slot order of the slot containing the reagent bottle in the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle; the liquid extractor is controlled to move to the target reagent ship corresponding to the target reagent ship number, the liquid extractor is controlled to move to the target slot of the target reagent ship that matches the target slot order, the liquid extractor is controlled to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form the target immune reagent according to the obtained target immune reagent component, and carry out development experiments for the target immune reagent, so as to realize automated development experiments and improve efficiency.

[0052] Furthermore, for the target reagent ship corresponding to the target reagent ship number, when the controller controls the liquid picker to move to the target slot of the target reagent ship that matches the target slot order, the controller can specifically perform the following steps: control the liquid picker to move to the reset point, control the reagent turntable to rotate so that the target reagent ship is at the liquid picking position; determine the target distance based on the correspondence between the pre-configured slot order and the distance, and the target slot order; after controlling the liquid picker to move the target distance from the reset point, determine that the liquid picker moves to the target slot of the target reagent ship that matches the target slot order.

[0053] The liquid taking position corresponds to the bottom of the liquid taking device after it moves to the reset point. The reagent boat is placed on the reagent turntable. By rotating the reagent turntable, the corresponding reagent boat can be placed at the liquid taking position. Figure 3 shown.

[0054] In the above manner, by rotating the reagent turntable, the corresponding reagent boat is located at the liquid extraction position, and the liquid extractor does not need to move between different reagent boats in a large range, but only needs to move between the tanks in a small range.

[0055] Furthermore, the target immune reagent component includes a first immune reagent component and a second immune reagent component; when the first immune reagent component and the second immune reagent component are located in the same reagent ship, for the target reagent ship corresponding to the target reagent ship number, the controller controls the liquid extractor to move to the target tank of the target reagent ship that matches the target tank sequence, and controls the liquid extractor to take out the target immune reagent component from the reagent bottle placed in the target tank. Specifically, the following steps can be performed: according to the correspondence between the pre-configured tank sequence and the distance, the first target tank sequence and the second target tank sequence, the first target tank sequence is determined respectively. target distance and second target distance; control the liquid picker to move to the reset point, control the reagent turntable to rotate so that the target reagent boat is at the liquid picking position; control the liquid picker to move the first target distance from the reset point, determine that the liquid picker moves to the first target slot that matches the sequence between the first target slots; control the liquid picker to take out the first target immune reagent component from the first target slot, add it to the reaction cup, control the liquid picker to move the second target distance from the reset point, determine that the liquid picker moves to the second target slot that matches the sequence between the second target slots, control the liquid picker to take out the second target immune reagent component from the second target slot, and add it to the reaction cup.

[0056] Furthermore, the target immune reagent component includes a third immune reagent component and a fourth immune reagent component; the third immune reagent component and the fourth immune reagent component are located in different reagent boats, wherein the reagent boat where the third immune reagent component is located is a third target reagent boat, and the reagent boat where the fourth immune reagent component is located is a fourth target reagent boat.

[0057] For the target reagent ship corresponding to the target reagent ship number, the controller controls the liquid picker to move to the target slot of the target reagent ship that is consistent with the target slot sequence, and controls the liquid picker to take out the target immune reagent component from the reagent bottle placed in the target slot. Specifically, the following steps may be included: according to the correspondence between the pre-configured slot sequence and the distance, the third target slot sequence and the fourth target slot sequence, respectively determine the third target distance and the fourth target distance; control the liquid picker to move to the reset point, control the reagent turntable to rotate so that the third target reagent ship is at the liquid taking position; after controlling the liquid picker to move the third target distance from the reset point, determine that the liquid picker moves to the third target slot that is consistent with the third target slot sequence; control the liquid picker to take out the third target immune reagent component from the third target slot; control the liquid picker to move to the reset point, control the reagent turntable to rotate so that the fourth target reagent ship is at the liquid taking position; after controlling the liquid picker to move the fourth target distance from the reset point, determine that the liquid picker moves to the fourth target slot that is consistent with the fourth target slot sequence; control the liquid picker to take out the fourth immune reagent component from the fourth target slot and add it to the reaction cup.

[0058] Exemplarily, the reagent components include: A1, B1, C1, D1, A2, B2, C2 and D2; these reagent components are placed in two reagent boats, the first reagent boat is A1-B1-C1-D1, and the second reagent boat is A2-B2-C2-D2.

[0059] If in the development experiment task, there are three groups of test agent component combinations: ①A1-B1-C1-D1; ②A2-B2-C2-D2; ③A1-B1-C2-D2.

[0060] When testing combination ①, control Figure 3 The reagent turntable shown rotates to place the first reagent boat at the liquid taking position, controls the liquid taker to move to the slot containing A1, takes A1 from the reagent bottle in the slot, adds it to the reaction cup, controls the liquid taker to move to the slot containing B1, takes B1 from the reagent bottle in the slot, controls the liquid taker to move to the slot containing C1, takes C1 from the reagent bottle in the slot, controls the liquid taker to move to the slot containing D1, takes D1 from the reagent bottle in the slot, after adding it to the reaction cup.

[0061] When testing combination ②, control Figure 3 The reagent turntable shown rotates to place the second reagent boat at the liquid taking position, controls the liquid taker to move to the slot containing A2, takes A2 from the reagent bottle in the slot, adds it to the reaction cup, controls the liquid taker to move to the slot containing B2, takes B2 from the reagent bottle in the slot, controls the liquid taker to move to the slot containing C2, takes C2 from the reagent bottle in the slot, controls the liquid taker to move to the slot containing D2, takes D2 from the reagent bottle in the slot, after adding it to the reaction cup.

[0062] When testing combination ③, control Figure 3 The reagent turntable shown rotates to rotate the first reagent boat to the liquid taking position, controls the liquid taker to move to the tank containing A1, takes A1 from the reagent bottle in the tank, adds it to the reaction cup, controls the liquid taker to move to the tank containing B1, takes B1 from the reagent bottle in the tank, adds it to the reaction cup, and controls Figure 3 The reagent turntable shown rotates to rotate the second reagent boat to the liquid taking position, and the liquid taker is controlled to the tank containing C2 to take C2 from the reagent bottle in the tank. After adding it to the reaction cup, the liquid taker is controlled to the tank containing D2 to take D2 from the reagent bottle in the tank.

[0063] It should be understood that, although the various steps in the flowcharts involved in the above-mentioned embodiments are displayed in sequence according to the indication of the arrows, these steps are not necessarily executed in sequence according to the order indicated by the arrows. Unless there is a clear explanation in this article, the execution of these steps does not have a strict order restriction, and these steps can be executed in other orders. Moreover, at least a part of the steps in the flowcharts involved in the above-mentioned embodiments can include multiple steps or multiple stages, and these steps or stages are not necessarily executed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a part of the steps or stages in other steps.

[0064] In one embodiment, Figure 4 As shown, an experimental processing device for developing immunological reagents is provided. When the same type of reagent components are formed in different ways or the types of reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components in different reagent bottles are different in at least one of the type and the formation method; the formation method includes a formula and a preparation process; the device includes:

[0065] The reagent component determination module 401 is used to determine the type and formation method of the target immune reagent components that form the target immune reagent according to the development experiment task for the target immune reagent;

[0066] The corresponding relationship acquisition module 402 is used to acquire the corresponding relationship between the pre-constructed first information and the second information; wherein the first information includes: the reagent ship number where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship; the second information includes: the type and formation method of the reagent component contained in the reagent bottle;

[0067] A positioning module 403 is used to obtain the target reagent ship number and the target slot order according to the corresponding relationship, the type of the target immune reagent component and the formation method;

[0068] The control module 404 is used to control the liquid extractor to move to the target slot of the target reagent ship corresponding to the target reagent ship number that matches the target slot sequence, control the liquid extractor to take out the target immune reagent component from the reagent bottle placed in the target slot, so as to form a target immune reagent according to the obtained target immune reagent component, and conduct a development experiment for the target immune reagent.

[0069] In one embodiment, the control module 304 is also used to control the liquid picker to move to a reset point, control the reagent turntable to rotate so that the target reagent ship is under the liquid picker; determine the target distance according to the correspondence between the pre-configured slot order and the distance, and the target slot order; after controlling the liquid picker to move the target distance from the reset point, determine that the liquid picker moves to the target slot of the target reagent ship that matches the target slot order.

[0070] In one embodiment, the target immune reagent component includes a first immune reagent component and a second immune reagent component; when the first immune reagent component and the second immune reagent component are located in the same reagent boat, the control module 304 is further used to determine the first target distance and the second target distance respectively according to the correspondence between the pre-configured slot order and the distance, the first target slot order and the second target slot order; control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the target reagent boat is at the liquid taking position; after controlling the liquid dispenser to move the first target distance from the reset point, determine that the liquid dispenser moves to the first target slot that matches the first target slot order; control the liquid dispenser to take out the first target immune reagent component from the first target slot, add it to the reaction cup, control the liquid dispenser to move the second target distance from the reset point, determine that the liquid dispenser moves to the second target slot that matches the second target slot order, and control the liquid dispenser to take out the second target immune reagent component from the second target slot and add it to the reaction cup.

[0071] In one embodiment, the target immune reagent component includes a third immune reagent component and a fourth immune reagent component; the third immune reagent component and the fourth immune reagent component are located in different reagent boats, wherein the reagent boat where the third immune reagent component is located is a third target reagent boat, and the reagent boat where the fourth immune reagent component is located is a fourth target reagent boat; the control module 304 is also used to determine the third target distance and the fourth target distance respectively according to the correspondence between the pre-configured slot order and the distance, the third target slot order and the fourth target slot order; control the liquid extractor to move to the reset point, and control the reagent turntable to rotate So that the third target reagent boat is at the liquid taking position; after controlling the liquid picker to move the third target distance from the reset point, determine that the liquid picker moves to the third target slot that matches the order between the third target slots; control the liquid picker to take out the third target immune reagent component from the third target slot and add it to the reaction cup; control the liquid picker to move to the reset point, control the reagent turntable to rotate so that the fourth target reagent boat is at the liquid taking position; after controlling the liquid picker to move the fourth target distance from the reset point, determine that the liquid picker moves to the fourth target slot that matches the order between the fourth target slots; control the liquid picker to take out the fourth immune reagent component from the fourth target slot and add it to the reaction cup.

[0072] In one embodiment, the reagent components include, by type: magnetic bead antibodies, blocking agents, marker antibodies, and biotin antibodies.

[0073] For the specific definition of the experimental processing device for immune reagent development, please refer to the definition of the experimental processing method for immune reagent development mentioned above, which will not be repeated here. Each module in the above-mentioned experimental processing device for immune reagent development can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the controller in hardware form, or can be stored in the memory in the controller in software form, so that the processor can call and execute the operations corresponding to the above modules.

[0074] In one embodiment, a controller is provided, whose internal structure diagram can be as follows: Figure 5 As shown. The controller includes a processor, a memory and a network interface connected via a system bus. Among them, the processor of the controller is used to provide computing and control capabilities. The memory of the controller includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The database of the controller is used to store experimental processing data for immune reagent development. The network interface of the controller is used to communicate with an external terminal via a network connection. The controller also includes an input and output interface, which is a connection circuit for exchanging information between the processor and an external device. They are connected to the processor via a bus, referred to as an I / O interface. When the computer program is executed by the processor, an experimental processing method for immune reagent development is implemented.

[0075] Those skilled in the art will understand that Figure 5 The structure shown in the figure is merely a block diagram of a partial structure related to the scheme of the present application, and does not constitute a limitation on the controller to which the scheme of the present application is applied. The specific controller may include more or fewer components than shown in the figure, or combine certain components, or have a different arrangement of components.

[0076] In one embodiment, a controller is provided, including a memory and a processor, wherein the memory stores a computer program, and the processor implements the steps in the above-mentioned various method embodiments when executing the computer program.

[0077] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0078] In one embodiment, a computer program product is provided, on which a computer program is stored, and the computer program is used by a processor to execute the steps in the above-mentioned various method embodiments.

[0079] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the above-mentioned computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0080] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0081] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. An experimental processing method for developing an immune reagent, characterized in that: When the same type of reagent components are formed in different ways, or the types of the reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components loaded in different reagent bottles are different in at least one of the types and the formation methods; The forming method includes a formula and a preparation process; the method includes: According to the development experimental task for the target immune reagent, determining the type and formation method of the target immune reagent components forming the target immune reagent; Obtaining a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots where the reagent bottle is placed among the slots of the reagent ship, and the second information includes: the type and formation method of the reagent component contained in the reagent bottle; According to the corresponding relationship, the type of target immune reagent component and the formation method, the target reagent ship number and the target slot order are obtained; Control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the target reagent boat is at the liquid dispensing position; the liquid dispensing position corresponds to the bottom of the liquid dispenser after it moves to the reset point; Determining a target distance according to a correspondence between a pre-configured slot order and a distance and the target slot order; After controlling the liquid taker to move the target distance from the reset point, determining that the liquid taker moves to a target tank of the target reagent ship that matches the target tank sequence, controlling the liquid taker to take out a target immune reagent component from a reagent bottle placed in the target tank, so as to form a target immune reagent according to the obtained target immune reagent component, and conducting a development experiment for the target immune reagent; When the target immune reagent component includes a third immune reagent component and a fourth immune reagent component, and the third immune reagent component and the fourth immune reagent component are located in different reagent boats, Determining the target distance according to the correspondence between the pre-configured inter-slot ordering and the distance, and the target inter-slot ordering, includes: determining the third target distance and the fourth target distance respectively according to the correspondence between the pre-configured inter-slot ordering and the distance, the third target inter-slot ordering and the fourth target inter-slot ordering.

2. The method according to claim 1, characterized in that The target immune reagent component includes a first immune reagent component and a second immune reagent component; in the case where the first immune reagent component and the second immune reagent component are located in the same reagent vessel; Determining the target distance according to the correspondence between the pre-configured slot order and the distance and the target slot order, including: determining the first target distance and the second target distance respectively according to the correspondence between the pre-configured slot order and the distance, the first target slot order and the second target slot order; After controlling the liquid picker to move the target distance from the reset point, determining that the liquid picker moves to the target slot of the target reagent boat that matches the sequence between the target slots, and controlling the liquid picker to take out the target immune reagent component from the reagent bottle placed in the target slot, including: after controlling the liquid picker to move the first target distance from the reset point, determining that the liquid picker moves to the first target slot that matches the sequence between the first target slots; controlling the liquid picker to take out the first target immune reagent component from the first target slot and add it to the reaction cup, controlling the liquid picker to move the second target distance from the reset point, determining that the liquid picker moves to the second target slot that matches the sequence between the second target slots, and controlling the liquid picker to take out the second target immune reagent component from the second target slot and add it to the reaction cup.

3. The method according to claim 1, characterized in that The reagent boat where the third immune reagent component is located is a third target reagent boat, and the reagent boat where the fourth immune reagent component is located is a fourth target reagent boat; Controlling the liquid taker to move to a reset point, controlling the reagent turntable to rotate so that the target reagent boat is at a liquid taking position, and controlling the liquid taker to move the target distance from the reset point, determining that the liquid taker moves to a target tank of the target reagent boat that matches the sequence between target tanks, and controlling the liquid taker to take out a target immune reagent component from a reagent bottle placed in the target tank, including: Control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the third target reagent boat is at the liquid dispensing position; After controlling the liquid picker to move the third target distance from the reset point, determining that the liquid picker moves to the third target tank that matches the sequence between the third target tanks; Controlling the liquid taking device to take out the third target immune reagent component from the third target tank and add it to the reaction cup; Control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the fourth target reagent boat is at the liquid dispensing position; After controlling the liquid picker to move a fourth target distance from the reset point, determining that the liquid picker moves to a fourth target tank that matches the order of the fourth target tanks; The liquid extractor is controlled to take out the fourth immune reagent component from the fourth target tank and add it to the reaction cup.

4. The method according to any one of claims 1 to 3, characterized in that: By type, reagent components include: magnetic bead antibodies, blocking agents, marker antibodies and biotin antibodies.

5. An experimental processing device for developing immune reagents, characterized in that: When the same type of reagent components are formed in different ways, or the types of the reagent components are different, the corresponding reagent components are loaded into different reagent bottles, so that the reagent components loaded in different reagent bottles are different in at least one of the types and the formation methods; The forming method includes a formula and a preparation process; the device includes: A reagent component determination module, used to determine the type and formation method of the target immune reagent components forming the target immune reagent according to the development experiment task for the target immune reagent; A correspondence acquisition module is used to acquire a correspondence between pre-constructed first information and second information; wherein the first information includes: the number of the reagent ship where the reagent bottle is located and the order of the slots containing the reagent bottle among the slots of the reagent ship; and the second information includes: the type and formation method of the reagent component contained in the reagent bottle; A positioning module, used to obtain the target reagent ship number and the target slot order according to the corresponding relationship, the type of the target immune reagent component and the formation method; A control module, used to control the liquid extractor to move to a reset point, and control the reagent turntable to rotate so that the target reagent boat is at a liquid extraction position; the liquid extraction position corresponds to the bottom of the liquid extractor after it moves to the reset point; The control module is further used to determine the target distance according to the correspondence between the pre-configured slot order and the distance and the target slot order; The control module is further used to control the liquid taker to move the target distance from the reset point, determine that the liquid taker moves to the target tank of the target reagent ship that matches the target tank sequence, control the liquid taker to take out the target immune reagent component from the reagent bottle placed in the target tank, so as to form a target immune reagent according to the obtained target immune reagent component, and perform a development experiment for the target immune reagent; When the target immune reagent component includes a third immune reagent component and a fourth immune reagent component, and the third immune reagent component and the fourth immune reagent component are located in different reagent boats, When the control module determines the target distance based on the correspondence between the pre-configured inter-slot ordering and the distance, and the target inter-slot ordering, it is specifically used to: determine the third target distance and the fourth target distance respectively based on the correspondence between the pre-configured inter-slot ordering and the distance, the third target inter-slot ordering, and the fourth target inter-slot ordering.

6. The device according to claim 5, characterized in that The target immune reagent component includes a first immune reagent component and a second immune reagent component; in the case where the first immune reagent component and the second immune reagent component are located in the same reagent vessel; When the control module determines the target distance according to the correspondence between the pre-configured slot order and the distance and the target slot order, the control module is specifically used to: determine the first target distance and the second target distance respectively according to the correspondence between the pre-configured slot order and the distance, the first target slot order and the second target slot order; The control module is specifically used to: after controlling the liquid picker to move the target distance from the reset point, determine that the liquid picker moves to the target slot of the target reagent boat that is consistent with the sequence between the target slots, and control the liquid picker to take out the target immune reagent component from the reagent bottle placed in the target slot, and is specifically used to: after controlling the liquid picker to move the first target distance from the reset point, determine that the liquid picker moves to the first target slot that is consistent with the sequence between the first target slots; after controlling the liquid picker to take out the first target immune reagent component from the first target slot and add it to the reaction cup, control the liquid picker to move the second target distance from the reset point, determine that the liquid picker moves to the second target slot that is consistent with the sequence between the second target slots, and control the liquid picker to take out the second target immune reagent component from the second target slot and add it to the reaction cup.

7. The device according to claim 5, characterized in that The reagent boat where the third immune reagent component is located is a third target reagent boat, and the reagent boat where the fourth immune reagent component is located is a fourth target reagent boat; The control module controls the liquid dispensing device to move to the reset point, controls the reagent turntable to rotate so that the target reagent boat is at the liquid dispensing position, and controls the liquid dispensing device to move the target distance from the reset point, determines that the liquid dispensing device moves to the target tank of the target reagent boat that matches the sequence between the target tanks, and controls the liquid dispensing device to take out the target immune reagent component from the reagent bottle placed in the target tank, specifically for: Control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the third target reagent boat is at the liquid dispensing position; After controlling the liquid picker to move the third target distance from the reset point, determining that the liquid picker moves to the third target tank that matches the sequence between the third target tanks; Controlling the liquid taking device to take out the third target immune reagent component from the third target tank and add it to the reaction cup; Control the liquid dispenser to move to the reset point, and control the reagent turntable to rotate so that the fourth target reagent boat is at the liquid dispensing position; After controlling the liquid picker to move a fourth target distance from the reset point, determining that the liquid picker moves to a fourth target tank that matches the order of the fourth target tanks; The liquid extractor is controlled to take out the fourth immune reagent component from the fourth target tank and add it to the reaction cup.

8. A controller comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the method according to any one of claims 1 to 4 is implemented.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method according to any one of claims 1 to 4 is implemented.

10. A computer program product, comprising a computer program, characterized in that When the computer program is executed by a processor, the method according to any one of claims 1 to 4 is implemented.

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