An automatic processing device for sample extraction and separation

Abstract

The present application discloses an automatic processing device for sample extraction and separation, comprising: a base, which is hollow inside to form a accommodating chamber; a gas delivery block, which is installed in the top area of ​​the base; a first transfer assembly, which is arranged in the accommodating chamber; and a second transfer assembly, which is arranged in the accommodating chamber, and the second transfer assembly is transmission-connected to the first transfer assembly; wherein the first deep-well plate is placed on the first transfer assembly, and the second deep-well plate is placed on the second transfer assembly, and under the action of the first transfer assembly and the second transfer assembly, the first deep-well plate is located directly below the second deep-well plate, and the second deep-well plate is contact-connected with the gas delivery block. According to the present application, it realizes movement with multiple degrees of freedom through two transfer assemblies, which reduces costs while ensuring functionality, and at the same time, the overall structure is compact, saves space, and ensures the adaptability of the overall device.

Description

Technical Field

[0001] The present application relates to the field of automation engineering, and more specifically, to an automatic processing device for sample extraction and separation. Background Art

[0002] In many fields such as chemical analysis, life science analysis, and clinical testing, the pretreatment of samples is a very important link and also the most time-consuming step. Often 70% of the time is spent on sample pretreatment. With the continuous development of industrial technology, the automation of sample pretreatment has become a popular development direction.

[0003] Currently, independent equipment is available for sample pre-treatment, but it still requires manual intervention and is difficult to integrate into an automated liquid handling workstation.

[0004] In view of this, it is necessary to develop an automatic processing device for sample extraction and separation to solve the above problems. Summary of the invention

[0005] In view of the shortcomings in the prior art, the main purpose of this application is to provide an automatic processing device for sample extraction and separation, which realizes multi-degree-of-freedom movement of the sample through two transfer components, thereby reducing costs while ensuring functionality. At the same time, the overall structure is compact, saves space, and ensures the adaptability of the overall device.

[0006] In order to achieve these purposes and other advantages according to the present application, an automatic processing device for sample extraction and separation is provided, comprising: a base, the interior of which is hollow to form a receiving chamber;

[0007] a gas delivery block mounted to a top region of the base;

[0008] A first transfer assembly is arranged in the accommodating chamber; and

[0009] A second transfer assembly is arranged in the accommodating chamber, and the second transfer assembly is transmission-connected to the first transfer assembly;

[0010] Wherein, the first deep-hole plate is placed on the first transfer assembly, and the second deep-hole plate is placed on the second transfer assembly.

[0011] Under the action of the first transfer assembly and the second transfer assembly, the first deep hole plate is located directly below the second deep hole plate, and the second deep hole plate is in contact and connected with the gas delivery block.

[0012] Preferably, the first transfer assembly comprises: a transfer driver fixedly mounted on the bottom area of ​​the accommodating chamber;

[0013] A screw transmission unit, which is transmission-connected to the power output end of the transfer driver;

[0014] an adapter plate fixedly connected to the movable part of the screw transmission unit; and

[0015] A supporting block, which is detachably connected to the adapter plate;

[0016] Among them, the screw transmission unit is sequentially provided with a loading station, a transfer station and a driving station along its transmission direction. Under the action of the transfer driver and the screw transmission unit, the supporting block reciprocates between the loading station and the transfer station, and the adapter plate reciprocates between the loading station, the transfer station and the driving station.

[0017] Preferably, a connecting piece is provided on the supporting block, a connecting portion is provided on the top area of ​​the adapter plate, and the connecting piece is detachably connected to the connecting portion.

[0018] Preferably, the first transfer assembly further comprises: a separation member fixedly mounted on the side wall of the base,

[0019] Under the action of the separating member, the connecting member is disconnected from the connecting portion.

[0020] Preferably, the second transfer assembly comprises: a transmission unit;

[0021] an adapter, which is fixedly connected to the transmission unit; and

[0022] A sample delivery unit, which is fixedly connected to the adapter;

[0023] When the adapter plate reaches the driving station, the adapter plate contacts the transmission unit to drive the sample transport unit to reciprocate in the vertical direction.

[0024] Preferably, the transmission unit comprises: a first transmission member and a second transmission member, the first transmission member and the second transmission member are both wedge-shaped, the first transmission member is transmission-connected to the second transmission member, and the second transmission member is fixedly connected to the adapter.

[0025] Preferably, a first slide rail is arranged between the first transmission member and the bottom wall of the base, and the first transmission member is fixedly connected to the movable part of the first slide rail.

[0026] A second slide rail is arranged between the second transmission member and the side wall of the base, and the second transmission member is fixedly connected to the movable part of the second slide rail.

[0027] Preferably, the sample delivery unit comprises: a support frame fixedly connected to the adapter;

[0028] A micro-actuator fixedly mounted on the support frame; and

[0029] A synchronous pulley unit is arranged in the support frame, and the synchronous pulley unit is transmission-connected to the power output end of the micro-driver.

[0030] Preferably, the gas delivery block is provided with gas outlet holes, the number of the gas outlet holes is no less than two, and the gas outlet holes are arranged in an array in the same layer along an array direction;

[0031] A connecting gas path is provided inside the gas delivery block, one end of the connecting gas path is connected to the gas outlet, and the other end of the connecting gas path is connected to an external gas source device.

[0032] Preferably, a sealing ring is arranged at the air outlet.

[0033] One of the above technical solutions has the following advantages or beneficial effects: the present application realizes movement with multiple degrees of freedom through two transfer components, thereby reducing costs while ensuring functionality. At the same time, the overall structure is compact, space-saving, and the adaptability of the overall device is ensured.

[0034] Other advantages, objectives and features of the present application will be reflected in part through the following description, and in part will be understood by those skilled in the art through study and practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings of the embodiments are briefly introduced below. Obviously, the drawings described below only relate to some embodiments of the present application, but are not intended to limit the present application, wherein:

[0036] Figure 1 A three-dimensional structural view of an automatic processing device for sample extraction and separation according to one embodiment of the present application;

[0037] Figure 2 A three-dimensional structural view of a hidden base and a gas delivery block for an automatic processing device for sample extraction and separation according to one embodiment of the present application;

[0038] Figure 3 A three-dimensional structural view of a gas delivery block according to one embodiment of the present application;

[0039] Figure 4 A three-dimensional structural view of a first transfer component according to one embodiment of the present application;

[0040] Figure 5 A three-dimensional structural view of a sample transport unit according to one embodiment of the present application. DETAILED DESCRIPTION

[0041] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0042] In the drawings, the shapes and dimensions may be exaggerated for clarity, and the same reference numerals will be used throughout to designate the same or like components.

[0043] Unless otherwise defined, the technical terms or scientific terms used herein shall have the usual meanings understood by persons of ordinary skill in the field to which this application belongs. The words "first", "second" and similar words used in the patent application specification and claims of this application do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, words such as "one", "one" or "the" do not indicate a quantitative limitation, but indicate the existence of at least one. Words such as "include" or "comprise" and similar words mean that the elements or objects appearing before "include" or "comprise" include the elements or objects listed after "include" or "comprise" and their equivalents, and do not exclude other elements or objects. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0044] In the following description, words such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc. are defined relative to the structure shown in the drawings. In particular, "height" is equivalent to the dimension from top to bottom, "width" is equivalent to the dimension from left to right, and "depth" is equivalent to the dimension from front to back. They are relative concepts and may change accordingly according to their different positions and different usage states. Therefore, these or other directions should not be interpreted as restrictive terms.

[0045] Terms related to attachment, coupling and the like (eg, "connected" and "attached") refer to a relationship in which structures are directly or indirectly fixed or attached to each other through intermediate structures, as well as a relationship in which they are movable or rigidly attached, unless expressly stated otherwise.

[0046] According to one embodiment of the present application, Figure 1As shown in FIG. 1 , it can be seen that the automatic processing device 100 for sample extraction and separation comprises: a base 110 , the interior of which is hollow to form a receiving chamber 111 ;

[0047] a gas delivery block 120 mounted on a top region of the base 110;

[0048] A first transfer assembly 130, which is arranged in the accommodating cavity 111; and

[0049] A second transfer assembly 140 is arranged in the accommodating chamber 111, and the second transfer assembly 140 is transmission-connected to the first transfer assembly 130;

[0050] The first deep-hole plate 150 is placed on the first transfer assembly 130 , and the second deep-hole plate 160 is placed on the second transfer assembly 140 .

[0051] Under the action of the first transfer assembly 130 and the second transfer assembly 140 , the first deep hole plate 150 is located directly below the second deep hole plate 160 , and the second deep hole plate 160 is in contact and connected with the gas delivery block 120 .

[0052] Further, the first transfer assembly 130 includes: a transfer driver 131, which is fixedly installed in the bottom area of ​​the accommodating chamber 111;

[0053] A screw transmission unit 132, which is transmission-connected to the power output end of the transfer driver 131;

[0054] an adapter plate 133 fixedly connected to the movable portion of the screw transmission unit 132; and a supporting block 134 detachably connected to the adapter plate 133;

[0055] Among them, the screw transmission unit 132 is sequentially provided with a loading station, a transfer station and a driving station along its transmission direction. Under the action of the transfer driver 131 and the screw transmission unit 132, the supporting block 134 reciprocates between the loading station and the transfer station, and the adapter plate 133 reciprocates between the loading station, the transfer station and the driving station.

[0056] Specifically, the transfer driver 131 drives the screw transmission unit 132 to move, so as to drive the adapter plate 133 and the supporting block 134 to the loading station, and the first deep hole plate 150 is placed on the supporting block 134. The transfer driver 131 drives the first deep hole plate 150 to the transfer station, and the adapter plate 133 is separated from the supporting block 134. The transfer driver 131 drives the adapter plate 133 to the driving station, so that the adapter plate 133 contacts the second transfer component 140, thereby driving the second transfer component 140 to move.

[0057] Furthermore, a connecting piece 135 is disposed on the supporting block 134 , a connecting portion 1331 is disposed on the top area of ​​the adapter plate 133 , and the connecting piece 135 is detachably connected to the connecting portion 133 .

[0058] Furthermore, the first transfer assembly 130 further includes: a separation member 136 , which is fixedly mounted on the side wall of the base 110 . Under the action of the separation member 136 , the connection member 135 is disconnected from the connection portion 1331 .

[0059] Specifically, when the transfer driver 131 drives the supporting block 134 to the transfer station, the connecting member 135 contacts the separating member 136. Under the action of the separating member 136, the connecting member 135 rotates so that the connecting member 135 is disconnected from the connecting portion 1331, and the adapter plate 133 is separated from the supporting block 134.

[0060] In the embodiment of the present application, a magnet 137 is further provided in the accommodating cavity 111 of the base 110 , and the magnet is arranged at the transfer station.

[0061] Further, the second transfer assembly 140 includes: a transmission unit 141; an adapter 142, which is fixedly connected to the transmission unit 141; and a sample delivery unit 143, which is fixedly connected to the adapter 142;

[0062] When the adapter plate 133 reaches the driving position, the adapter plate 133 contacts the transmission unit 141 to drive the sample transport unit 143 to reciprocate in the vertical direction.

[0063] In the embodiment of the present application, the second deep well plate 160 is placed on the sample transport unit 143 .

[0064] Furthermore, the transmission unit 141 includes: a first transmission member 1411 and a second transmission member 1412 , the first transmission member 1411 and the second transmission member 1412 are both wedge-shaped, and the first transmission member 1411 is transmission-connected to the second transmission member 1412 , and the second transmission member 1412 is fixedly connected to the adapter 142 .

[0065] Furthermore, a first slide rail 1413 is arranged between the first transmission member 1411 and the bottom wall of the base 110 , and the first transmission member 1411 is fixedly connected to a movable portion of the first slide rail 1413 .

[0066] A second slide rail 1414 is arranged between the second transmission member 1412 and the side wall of the base, and the second transmission member 1412 is fixedly connected to a movable portion of the second slide rail 1414 .

[0067] Specifically, the transfer driver 131 drives the adapter plate 133 to the driving station so that the adapter plate 133 contacts the first transmission member 1411. The transfer driver 131 further drives the adapter plate 133 to move, so as to cause relative displacement between the first transmission member 1411 and the second transmission member 1412, thereby driving the sample delivery unit 143 and the second deep well plate 160 to move in the vertical direction, so as to control the contact and connection between the second deep well plate 160 and the gas delivery block 120.

[0068] Further, the sample delivery unit 143 includes: a support frame 1431 , which is fixedly connected to the adapter 142 ;

[0069] A micro driver 1432, which is fixedly mounted on the support frame 1431; and

[0070] The synchronous pulley unit 1433 is disposed in the support frame 1431 , and the synchronous pulley unit 1433 is transmission-connected to the power output end of the micro-driver 1432 .

[0071] It can be understood that the second deep hole plate 160 is placed on the synchronous pulley unit 1433, and the micro driver 1432 drives the synchronous pulley unit 1433 to move, and synchronously drives the second deep hole plate 160 to move, so that the second deep hole plate 160 is accurately connected to the gas delivery block 120.

[0072] Furthermore, the gas delivery block 120 is provided with gas outlet holes 121, and the number of the gas outlet holes 121 is no less than two, and the gas outlet holes 121 are arranged in an array in the same layer along an array direction;

[0073] A connecting gas path is provided inside the gas delivery block 120 , one end of the connecting gas path is connected to the gas outlet 121 , and the other end of the connecting gas path is connected to an external gas source device.

[0074] Furthermore, a sealing ring 122 is arranged at the gas outlet 121 to ensure the air tightness when the second deep hole plate 160 contacts the gas delivery block 120 so as to provide positive pressure.

[0075] In an embodiment of the present application, the second deep well plate 160 may be configured with a filter membrane to achieve magnetic bead filtration and protein precipitation. The second deep well plate 160 may also be configured with different fillers to achieve the functions of solid phase extraction and supported liquid-liquid extraction.

[0076] It can be understood that, under the action of an external gas source device, the gas delivery block 120 provides gas to the second deep hole plate 160 to provide positive pressure, thereby pressing the liquid in the second deep hole plate 160 into the first deep hole plate 150 .

[0077] The number of devices and processing scales described here are used to simplify the description of this application. Applications, modifications and variations of this application are obvious to those skilled in the art.

[0078] Although the embodiments of the present application have been disclosed as above, they are not limited to the applications listed in the specification and the embodiments. It can be fully applied to various fields suitable for the present application. For those familiar with the art, additional modifications can be easily realized. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present application is not limited to the specific details and the illustrations shown and described here.

Claims

1. An automatic processing device for sample extraction and separation, characterized in that: include: A base (110) having a hollow interior to form a receiving cavity (111); a gas delivery block (120) mounted on a top region of the base (110); A first transfer assembly (130) arranged in the accommodating chamber (111); as well as a second transfer assembly (140), which is arranged in the accommodating chamber (111), and the second transfer assembly (140) is transmission-connected to the first transfer assembly (130); The first deep-hole plate (150) is placed on the first transfer assembly (130), and the second deep-hole plate (160) is placed on the second transfer assembly (140). Under the action of the first transfer assembly (130) and the second transfer assembly (140), the first deep hole plate (150) is located directly below the second deep hole plate (160), and the second deep hole plate (160) is in contact and connected with the gas delivery block (120); The first transfer assembly (130) comprises: a transfer driver (131) fixedly mounted on the bottom area of ​​the accommodating chamber (111); A screw drive unit (132) which is in driving connection with the power output end of the transfer drive (131); an adapter plate (133) fixedly connected to the movable part of the screw transmission unit (132); and A supporting block (134) which is detachably connected to the adapter plate (133); The screw transmission unit (132) is provided with a loading station, a transfer station and a driving station in sequence along its transmission direction; under the action of the transfer driver (131) and the screw transmission unit (132), the support block (134) reciprocates between the loading station and the transfer station, and the adapter plate (133) reciprocates between the loading station, the transfer station and the driving station; The transfer driver (131) drives the screw drive unit (132) to move, so as to drive the adapter plate (133) and the supporting block (134) to the loading station, the first deep hole plate (150) is placed on the supporting block (134), the transfer driver (131) drives the first deep hole plate (150) to the transfer station, the adapter plate (133) is separated from the supporting block (134), and the transfer driver (131) drives the adapter plate (133) to the driving station, so that the adapter plate (133) contacts the second transfer assembly (140), thereby driving the second transfer assembly (140) to move; The supporting block (134) is provided with a connecting piece (135), the top area of ​​the adapter plate (133) is provided with a connecting portion (1331), and the connecting piece (135) is detachably connected to the connecting portion (1331); The first transfer assembly (130) further comprises: a separation member (136) fixedly mounted on a side wall of the base (110); When the transfer driver (131) drives the supporting block (134) to the transfer station, the connecting member (135) contacts the separating member (136), and under the action of the separating member (136), the connecting member (135) rotates, so that the connecting member (135) is disconnected from the connecting portion (1331), and the adapter plate (133) is separated from the supporting block (134); The second transfer assembly (140) comprises: a transmission unit (141); An adapter (142) fixedly connected to the transmission unit (141); and A sample delivery unit (143), which is fixedly connected to the adapter (142); When the adapter plate (133) reaches the driving station, the adapter plate (133) contacts the transmission unit (141) to drive the sample delivery unit (143) to reciprocate in a vertical direction; the second deep-hole plate (160) is placed on the sample delivery unit (143); The transmission unit (141) comprises: a first transmission member (1411) and a second transmission member (1412), the first transmission member (1411) and the second transmission member (1412) are both wedge-shaped, the first transmission member (1411) and the second transmission member (1412) are transmission-connected, and the second transmission member (1412) is fixedly connected to the adapter member (142); A first slide rail (1413) is arranged between the first transmission member (1411) and the bottom wall of the base (110), and the first transmission member (1411) is fixedly connected to a movable portion of the first slide rail (1413); A second slide rail (1414) is arranged between the second transmission member (1412) and the side wall of the base, and the second transmission member (1412) is fixedly connected to a movable portion of the second slide rail (1414); The transfer driver (131) drives the adapter plate (133) to the driving station so that the adapter plate (133) contacts the first transmission member (1411). The transfer driver (131) further drives the adapter plate (133) to move, so as to cause relative displacement between the first transmission member (1411) and the second transmission member (1412), thereby driving the sample delivery unit (143) and the second deep-well plate (160) to move in a vertical direction, so as to control the second deep-well plate (160) to contact and connect with the gas delivery block (120).

2. The automatic processing device for sample extraction and separation according to claim 1, characterized in that: The sample transport unit (143) comprises: a support frame (1431) fixedly connected to the adapter (142); A micro-driver (1432) fixedly mounted on the support frame (1431); and A synchronous pulley unit (1433) is arranged in the support frame (1431), and the synchronous pulley unit (1433) is transmission-connected to the power output end of the micro-driver (1432); the second deep hole plate (160) is placed on the synchronous pulley unit (1433), and the micro-driver (1432) drives the synchronous pulley unit (1433) to move, thereby synchronously driving the second deep hole plate (160) to move, so that the second deep hole plate (160) is accurately connected to the gas delivery block (120).

3. The automatic processing device for sample extraction and separation according to claim 1, characterized in that: The gas delivery block (120) is provided with gas outlet holes (121), and at least two gas outlet holes (121) are provided, and the gas outlet holes (121) are arranged in an array in the same layer along an array direction; A connecting gas path is provided inside the gas delivery block (120), one end of the connecting gas path is connected to the gas outlet (121), and the other end of the connecting gas path is connected to an external gas source device.

4. The automatic processing device for sample extraction and separation according to claim 3, characterized in that: A sealing ring (122) is arranged at the air outlet hole (121).

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