A device and method for microneedle patch injection and detachment

Abstract

The application discloses a device and method for microneedle patch injection and peeling, and relates to the technical field of microneedle patch application devices, which comprises a shell, a sliding groove is arranged on the side wall of the shell; an injection mechanism is arranged in the shell and comprises a hollow spring push rod, a spring guide rod is arranged on the top of the spring push rod, the spring guide rod is fixed on the top of the shell, and the spring guide rod is sleeved with a spring on the side of the top of the spring push rod; a clamping mechanism is fixed on the bottom of the spring push rod and comprises a sliding rail, a pair of clamping blocks are symmetrically arranged on the sliding rail, the clamping blocks are connected with an adjusting mechanism to realize the approaching or moving away of the clamping blocks, the sliding rail penetrates through the sliding groove and is connected with a pusher, the clamping mechanism is compressed and locked through the pusher, the pusher is released, and the microneedle patch in the clamping block is pushed through the action of the spring; the device can uniformly penetrate the drug-loaded tip of the microneedle patch into the skin through external force and peel the microneedle patch or the base of the microneedle patch from the surface of the skin.

Description

Technical Field

[0001] This invention relates to the field of microneedle patch application device technology, and in particular to a device and method for microneedle patch injection and removal. Background Technology

[0002] Common types of microneedle patches include: metal microneedles, silica microneedles, hydrogel microneedles, and dissolvable microneedles. During use, pressure is typically applied by hand to press the microneedle patch into the skin, causing the drug-loaded tips to pierce the stratum corneum. After the drug at the tips dissolves, the microneedle patch is then peeled off the skin surface.

[0003] Microneedles have extremely fine tips, making them highly susceptible to breakage during application. To ensure successful insertion into the skin, the smoothness of the insertion surface and the pressure and speed of application are crucial. Manual pressing ignores the impact of skin surface smoothness and cannot guarantee even pressure, significantly increasing the risk of tip breakage. Furthermore, frequent contact between the hands and the treated area greatly increases the risk of bacterial infection, significantly reducing the effectiveness of microneedling.

[0004] For microneedles made of hard materials like metals and silica, which are insoluble, the drug is usually attached to the drug-carrying tip via a coating. Therefore, the entire microneedle patch needs to be peeled off the skin after drug delivery. For some microneedles with soluble tips, the supporting substrate still needs to be peeled off the skin surface after use. Because the microneedle patch is extremely small and tightly embedded in the skin, peeling it off after drug delivery is very inconvenient. For fully soluble microneedles, the drug-carrying tip needs to be dissolved before the solution is introduced separately. The solution dissolves the substrate, allowing the microneedle patch to separate from the skin. However, this process is cumbersome, and improper solution introduction can significantly reduce user comfort. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the present invention aims to provide an apparatus and method for microneedle patch injection and removal. This apparatus can provide external force to uniformly insert the drug-loaded tip of the microneedle patch into the skin and remove the microneedle patch or its base from the skin surface. Using this apparatus for microneedle patch injection and removal can greatly reduce bacterial contamination of the affected area and improve the injection efficiency of microneedles.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solution:

[0007] In a first aspect, a device for injecting and peeling microneedle patches includes:

[0008] The housing has a sliding groove at the bottom of its side wall.

[0009] The injection mechanism is located inside the housing and includes a hollow spring push rod. The top of the spring push rod is nested with a spring guide rod. The spring guide rod is fixed to the top of the housing, and a spring is sleeved around the periphery of the spring guide rod at the top of the spring push rod.

[0010] The clamping mechanism is fixed to the bottom of the spring push rod and includes a slide rail. A pair of clamping blocks are symmetrically arranged on the slide rail. The clamping blocks are connected to an adjustment mechanism to move the clamping blocks closer or further away. The two ends of the slide rail pass through the sliding groove and are connected to the pusher. The pusher drives the clamping mechanism to compress the spring and lock it. The pusher is released and the micro-needle patch inside the clamping block is pushed by the spring.

[0011] As a further implementation, the bottom of the housing is open, including an outer shell, which is inverted and U-shaped, with side baffles connected to both sides of the outer shell, and the sliding groove is provided on the side baffles.

[0012] As a further implementation, the spring guide rod has a T-shaped cross-section, with its bottom rod-shaped structure passing through the outer shell and sleeved with the spring push rod, and its top plate-shaped structure supported by the top surface of the outer shell. A solution channel is provided inside the spring guide rod, and the top of the solution channel is connected to an end cap.

[0013] As a further implementation, the clamping mechanism includes a clamping housing, an opening at the bottom of the clamping housing, a drip hole on the clamping housing, and a sliding plate inside the clamping housing.

[0014] As a further implementation, the slide rail passes through clamping blocks at both ends and through the housing to be fixedly engaged with the pusher. The slide rail is located at the bottom of the sliding plate and is arranged parallel to the sliding plate.

[0015] As a further implementation, a drip outlet is provided in the middle of the sliding plate, and clamping block grooves with opposite inclination directions are provided on both sides of the drip outlet, with the top of the clamping block cooperating with the clamping block groove.

[0016] As a further implementation, the adjustment mechanism includes a threaded guide rod that engages with the side wall of the sliding plate, and an inverted T-shaped groove on the housing. The threaded guide rod passes through the T-shaped groove and engages with the adjustment knob. Rotating the adjustment knob enables the sliding plate to move laterally, and the two clamping blocks move closer or further apart through the clamping block groove.

[0017] As a further implementation, the drip outlet is located on the axis of the solution channel, and the threaded guide rod is set perpendicular to the slide rail.

[0018] As a further implementation, the clamping mechanism, spring guide rod, and spring push rod are located on the same axis.

[0019] Secondly, a method for operating a device for microneedle patch injection and removal, characterized in that it employs any of the above-described devices for microneedle patch injection and removal, comprising the following steps:

[0020] Rotate the adjustment knob to control the two clamping blocks to clamp the microneedle patch;

[0021] The upward pushing component drives the slide rail to move along the sliding groove, thereby moving the clamping mechanism upward and compressing the spring;

[0022] The device is moved to the skin surface where the microneedles will be applied. The pusher is released, and the microneedle patch is inserted into the skin under the action of the spring.

[0023] After the drug delivery tip of the microneedle patch has completed injection, continue to rotate the adjustment knob in the same direction to increase the clamping force of the clamping block on the microneedle patch, push the pusher upward to peel the microneedle patch off the skin; or, control the threaded guide rod to move laterally along the T-groove by adjusting the knob until there is no resistance in the process, then push the pusher upward to peel off the base of the microneedle patch.

[0024] Rotate the adjustment knob in the opposite direction to release the microneedle patch.

[0025] The beneficial effects of the present invention are as follows:

[0026] 1. This invention uses a pusher to move the clamping mechanism upward along the sliding groove and compress the spring. After the pusher is released, the spring force is used to insert the microneedle patch inside the clamping block into the skin, which can greatly reduce bacterial contamination of the affected area and improve the injection efficiency of the microneedle. After the drug delivery tip of the microneedle patch has completed the injection, the clamping block is further clamped by the adjustment mechanism, which can realize the peeling of the microneedle patch or the microneedle patch base from the skin surface.

[0027] 2. The present invention has an inverted T-shaped groove on the shell, a threaded guide rod passing through the T-shaped groove and cooperating with the adjustment knob, and a corresponding long groove on the clamping shell baffle. After the drug delivery tip of the microneedle patch has completed injection, the adjustment knob can be moved horizontally left and right along the T-shaped groove to achieve the peeling of the microneedle patch or microneedle patch base from the skin surface.

[0028] 3. The solution channel, drip nozzle, and drip hole of this invention enable the solution to act directly on the bottom of the microneedle patch from the drip nozzle, accelerating its dissolution speed and greatly alleviating the discomfort caused to patients due to the prolonged adhesion of the substrate to the skin. Attached Figure Description

[0029] The accompanying drawings, which form part of this invention, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an improper limitation of the invention.

[0030] Figure 1 This is a schematic diagram of the overall structure of a microneedle patch injection and peeling device according to an embodiment of the present invention.

[0031] Figure 2 This is a cross-sectional structural diagram of a microneedle patch injection and peeling device according to an embodiment of the present invention.

[0032] Figure 3 This is an exploded structural diagram of a microneedle patch injection and peeling device according to an embodiment of the present invention.

[0033] Figure 4 This is a schematic diagram of the clamping mechanism in an embodiment of the present invention.

[0034] Figure 5 This is a front view of the clamping mechanism in an embodiment of the present invention.

[0035] Figure 6 This is a front view of the sliding plate in an embodiment of the present invention.

[0036] The diagram exaggerates the spacing or dimensions between parts to show their positions; the diagram is for illustrative purposes only.

[0037] Wherein: 1-Adjusting knob, 2-Outer shell, 3-Spring guide rod, 4-End cap, 5-Side baffle, 6-Pushing component, 7-Spring, 8-Spring push rod, 9-Clamping mechanism, 10-Solution channel; 5-1-Sliding groove, 9-1-Clamping outer shell, 9-1-1-Drip hole, 9-2-Sliding plate, 9-2-1-Drip outlet, 9-2-2-Clamping block groove, 9-3-Threaded guide rod, 9-4-Threaded rod, 9-5-Slide rail, 9-6-Clamping block, 9-7-Clamping outer shell baffle. Detailed Implementation

[0038] It should be noted that the following detailed description is illustrative and intended to provide further explanation of the invention. Unless otherwise specified, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0039] Example 1

[0040] In a typical embodiment of the present invention, reference is made to Figures 1-6 As shown, a device for injecting and peeling microneedle patches includes a housing and an injection mechanism and a clamping mechanism 9 disposed inside the housing. The clamping mechanism 9 is fixed to the bottom of the injection mechanism and is used to clamp the microneedle patch. The injection mechanism drives the clamping mechanism 9 to move along the axial direction of the housing so that the microneedle patch held in the clamping mechanism 9 can be inserted into the human skin.

[0041] like Figures 1-3As shown, the housing has an opening at the bottom and includes an inverted, U-shaped outer shell 2 made of transparent acrylic material. The outer shell 2 includes two side panels and a top connecting the side panels, with side baffles connecting to close the outer shell on both sides. Figure 3 Taking the view direction as an example, the side baffles 5 are set on the left and right sides of the outer shell, and the two side plates of the outer shell are the front and rear sides. The bottom of the two side baffles 5 is provided with sliding grooves 5-1, which are set along the length of the side baffles.

[0042] like Figure 2 and Figure 3 As shown, a circular opening is provided in the middle of the top plate for the spring guide rod 3 to pass through. The spring guide rod 3 has a T-shaped cross-section. Its bottom rod-shaped structure (a round rod of a set length) passes through the top plate of the outer shell and is sleeved with the spring push rod 8. Its top plate-shaped structure (a square support plate) is supported by the top surface of the outer shell. A solution channel 10 is provided in the axial direction inside the spring guide rod 3. The solution channel 10 passes through the round rod and the support plate. A circular groove is provided in the middle of the top of the support plate. An end cap 4 is provided at the circular groove.

[0043] Understandably, the support plate is fixed to the top plate of the outer casing at the four corners by screws.

[0044] The injection mechanism includes a spring guide rod 3 and a spring push rod 8. The spring push rod 8 is cylindrical and hollow inside, which also forms a solution channel 10. The top of the spring push rod 8 is nested around the spring guide rod 3, so that the spring push rod 8 and the spring guide rod 3 are slidably connected.

[0045] Spring 7 is sleeved around the spring guide rod 3. One end of spring 7 abuts against the top surface of spring push rod 8, and the other end abuts against the bottom surface of the top plate of the outer casing. When spring push rod 8 moves upward, spring 7 is compressed. After spring push rod 8 is released, spring 7 pushes spring guide rod 3 to move downward quickly under the action of spring 7.

[0046] like Figures 3-5 As shown, the clamping mechanism 9 is located at the bottom of the injection mechanism. The clamping mechanism 9 includes a clamping housing 9-1 with an opening at the bottom. The clamping housing 9-1 is also U-shaped, with clamping housing baffles 9-7 on both sides. A drip hole 9-1-1 is provided in the middle of the top plate of the clamping housing. The drip hole 9-1-1 is corresponding to the bottom opening of the spring push rod 8. The top plate of the clamping housing 9-1 is fixedly connected to the bottom of the spring push rod 8 so that the spring push rod 8 can drive the clamping housing 9-1 to move up and down.

[0047] The two side plates of the clamping housing 9-1 are connected by slide rails 9-5. In this embodiment, the two side plates of the clamping housing 9-1 are arranged parallel to the two side baffles 5 of the housing, and the baffles of the clamping housing 9-1 are arranged parallel to the two side plates of the housing 2.

[0048] A pair of clamping blocks 9-6 are symmetrically arranged on the slide rail 9-5. The slide rail 9-5 and the two clamping blocks 9-6 are slidably arranged. The clamping blocks 9-6 are connected to the adjustment mechanism to make the clamping blocks 9-6 move closer or further away. The two ends of the slide rail pass through the sliding groove and are connected to the pusher. The pusher 6 drives the clamping mechanism 9 to compress the spring and lock it. When the pusher 6 is released, the microneedle patch in the clamping block is inserted into the skin by the action of the spring.

[0049] Specifically, the slide rail 9-5 passes through the clamping block at both ends and through the sliding groove 5-1 on the side baffle to be fixedly engaged with the pusher. The clamping housing 9-1 is provided with a sliding plate 9-2 inside. The sliding plate 9-2 is located at the bottom of the clamping housing 9-1 and is parallel to the top plate of the clamping housing 9-1. The slide rail 9-5 is located at the bottom of the sliding plate 9-2 and is parallel to the sliding plate 9-2.

[0050] The clamping blocks 9-6 are T-shaped, and the two clamping blocks 9-6 are set opposite each other.

[0051] A drip nozzle 9-2-1 is provided in the middle of the sliding plate 9-2. The drip nozzle 9-2-1 is corresponding to the drip hole 9-1-1. The drip nozzle 9-2-1 is located on the axis of the solution channel 10. In this embodiment, the drip nozzle 9-2-1 is oblong, so that after the sliding plate 9-2 moves laterally, the solution flowing out of the drip hole 9-1-1 can still pass through the drip nozzle 9-2-1.

[0052] Furthermore, clamping block grooves 9-2-2 with opposite inclination directions are provided on both sides of the drip outlet. In this embodiment, the inclination angle of the two clamping block grooves 9-2-2 is 45°, and the top of the clamping block 9-6 cooperates with the clamping block groove 9-2-2 through a guide rod.

[0053] The adjustment mechanism includes a threaded guide rod 9-3 that fits into the side wall of the sliding plate 9-2. The threaded guide rod 9-3 is set perpendicularly to the slide rail 9-5. An inverted T-shaped groove is set at the bottom of the outer shell side plate. A corresponding long groove is set on the clamping outer shell baffle 9-7. After the threaded guide rod passes through the long groove and the T-shaped groove, it engages with the adjustment knob 1. Rotating the adjustment knob 1 enables the sliding plate to move laterally, and the two clamping blocks 9-6 move closer or further away through the clamping block slide groove 9-2-2.

[0054] The sliding plate 9-2 is also provided with a threaded rod 9-4 on its side wall. The threaded rod and the threaded guide rod are respectively located near the two ends of the sliding plate side wall. The outer shell side plate is also provided with a T-shaped groove corresponding to the threaded rod.

[0055] In this embodiment, the clamping mechanism, spring guide rod, and spring push rod are located on the same axis.

[0056] Understandably, the slide rail 9-5 consists of two long cylindrical rods, therefore two sliding grooves 5-1 are provided on the two side baffles, and grooves are provided on both ends of the slide rail 9-5. The pushing component 6 includes a fixed plate, and two insert rods are provided on one side of the fixed plate for engaging with the grooves. The two insert rods are inserted into the ends of the slide rail, and by pinching the two fixed plates and pushing the slide rail upward, the spring can be compressed.

[0057] In another example, the pusher 6 includes a fixing plate with two grooves on one side, through which the fixing plate engages with two slide rails.

[0058] In actual operation, first turn the adjustment knob to control the sliding plate to slide back and forth, thereby clamping the microneedle patch with the clamping block. Then, pinch the two pushers and push them up to compress the spring. The device moves to the skin surface where the microneedle is to be applied. Release the pushers, and under the action of the spring, push the spring push rod and clamping mechanism to move downward quickly, thereby allowing the microneedle patch to pierce the human skin.

[0059] Example 2

[0060] A method for operating a device for microneedle patch injection and removal, employing the device for microneedle patch injection and removal described in Example 1, includes the following steps:

[0061] This embodiment is applicable to the single injection of various types of microneedle patches. When using it, the single microneedle patch first needs to be fixedly clamped in the clamping block 9-6 of the clamping mechanism 9.

[0062] When fixing the microneedle patch, ensure that the tip of the microneedle patch is facing down and the back of the substrate is in close contact with the upper surface of the clamping block 9-6. After the microneedle patch is placed in the appropriate position, rotate the adjusting knob 1. The adjusting knob 1 will drive the threaded guide rod 9-3 to rotate, which in turn will drive the sliding plate 9-2 to move back and forth.

[0063] As the sliding plate 9-4 moves back and forth, it drives the clamping block 9-6 in the clamping block groove 9-2-2 to move left and right along the slide rail 9-5, clamping or releasing the microneedle patch. Turning the adjusting knob 1 clockwise moves the sliding plate 9-2 forward and the clamping block 9-6 towards the center of the device, clamping the microneedle patch.

[0064] The upward movement of push rod 6 causes clamping mechanism 9 and spring push rod 8 to move upward along spring guide rod 3, and slide rail moves along sliding groove, compressing spring 7 mounted on the upper end of spring push rod 8. Pushing push rod 6 upward until locked moves the device to the skin surface where the microneedle is to be applied. Pushing push rod 6 downward unlocks the device, and spring push rod 8 accelerates downward under the action of spring force, allowing the microneedle patch to pierce the skin.

[0065] The injection process of the microneedle patch can be observed through the transparent casing of the device. After the drug delivery tip of the microneedle patch has completed injection, rotate the adjusting knob 1 clockwise again to ensure that the microneedle patch is firmly clamped, and push the push rod 6 upward to peel the microneedle patch off the skin. Remove the device from the skin surface, rotate the adjusting knob 1 counterclockwise, and the microneedle patch will be released, completing one microneedle patch injection and removal cycle.

[0066] In this embodiment, the microneedle patch is made of insoluble metal microneedles or silica microneedles. After the drug applied to the tip of the microneedle is delivered, the entire microneedle patch needs to be peeled off from the skin surface. This requires the clamping mechanism to provide a large clamping force. Therefore, the step of rotating the adjustment knob clockwise again after the microneedle is inserted into the skin is crucial and cannot be ignored.

[0067] It should be noted that the threaded guide rod and sliding plate, which convert rotational motion into linear motion in this device, can also be replaced by isomorphic gear and rack meshing structures. Since the above two structures are conventional mechanical transmission mechanisms, they are not shown in detail in this embodiment.

[0068] Example 3

[0069] A method for operating a device for microneedle patch injection and removal, employing the device for microneedle patch injection and removal described in Example 1, includes the following steps:

[0070] The fixation, clamping, and injection of the microneedle patch in this embodiment are basically the same as in Embodiment 2. The difference is that after the microneedle patch is injected into the skin, the adjustment knob 1 is no longer rotated to adjust the clamping degree of the clamping blocks 9-6. Instead, the adjustment knob 1 needs to be moved horizontally left and right along the T-shaped groove on the housing 2. When there is almost no resistance when moving the adjustment knob 1, the pusher 6 is pushed up to peel the microneedle patch base off the skin. The device is then removed from the skin surface, and the adjustment knob 1 is rotated counterclockwise to release the microneedle patch base, completing one injection and peeling of the microneedle patch.

[0071] In this embodiment, the drug-carrying tip of the microneedle patch is made of a soluble biocompatible material, while the base is made of an insoluble material. Therefore, it is necessary to separate the microneedle base from the drug-carrying tip after the microneedle tip is inserted into the skin, and peel the microneedle base off the skin.

[0072] The connection between the microneedle substrate and the drug-loaded tip of this type of microneedle is usually achieved by mechanical structural chains or material adhesive bonding. Therefore, only a small shear force needs to be applied in the horizontal direction at the root of the microneedle to separate the substrate from the drug-loaded tip.

[0073] In this embodiment, the adjustment knob provides shearing force by moving back and forth in a small range in the horizontal direction, which can separate the substrate from the drug-loaded microneedles. Pushing the pusher separates the substrate from the skin, and the drug-loaded tip remaining in the skin can still deliver drugs continuously, avoiding the problem of discomfort caused by the microneedle patch substrate being attached to the skin for a long time.

[0074] Example 4

[0075] A method for operating a device for microneedle patch injection and removal, employing the device for microneedle patch injection and removal described in Example 1.

[0076] The method of fixing, clamping and injecting the microneedle patch in this embodiment is basically the same as that in embodiment two. The difference is that after the microneedle patch is injected into the skin, a solution needs to be injected into the microneedle patch base through the solution channel 10 located in the injection device.

[0077] A removable end cap 4 is installed on the upper end of the spring guide rod 3. After removing the end cap 4, the solution channel 10 located inside the injection device can be seen. A dropper containing an aqueous solution can be placed in the solution channel 10. The solution in the dropper can reach the microneedle patch substrate through the drip hole 9-1-1 on the clamping housing 9-1 and the drip outlet 9-2-1 on the sliding plate 9-2, and dissolve it. After the microneedle patch substrate has been fully dissolved, push the pusher 6 upward to lift the clamping mechanism 9 and remove the device from the skin surface.

[0078] In this embodiment, both the drug-carrying tip and the substrate of the microneedle patch are made of soluble biocompatible materials. Therefore, after the injection of the microneedle patch is completed, the device needs to remain on the skin surface for a period of time to allow the drug-carrying tip to dissolve and release the drug before injecting an aqueous solution into the microneedle patch substrate through the solution channel to dissolve it.

[0079] Using a dropper to draw an aqueous solution to dissolve the microneedle base allows for convenient selection and control of the type and amount of solution. The solution is applied directly to the bottom of the microneedle patch from a concentrated drip nozzle, which can accelerate the dissolution rate and greatly alleviate the discomfort caused to patients due to prolonged adhesion of the base to the skin.

[0080] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A device for injecting and peeling microneedle patches, characterized in that, include: The housing has sliding grooves on its side walls; The injection mechanism is located inside the housing and includes a hollow spring push rod. The top of the spring push rod is nested with a spring guide rod. The spring guide rod is fixed to the top of the housing, and a spring is sleeved around the periphery of the spring guide rod at the top of the spring push rod. The clamping mechanism is fixed to the bottom of the spring push rod and includes a slide rail. A pair of clamping blocks are symmetrically arranged on the slide rail. The clamping blocks are connected to the adjustment mechanism to make the clamping blocks move closer or further away. The two ends of the slide rail pass through the sliding groove and are connected to the pusher. The pusher drives the clamping mechanism to compress the spring and lock it. The pusher is released and the micro-needle patch inside the clamping block is pushed by the spring. The clamping mechanism includes a clamping housing with a drip hole and an opening at the bottom. A sliding plate is provided inside the clamping housing. The slide rail passes through the clamping blocks at both ends and through the housing to be fixedly engaged with the pusher. The slide rail is located at the bottom of the sliding plate and is parallel to the sliding plate. The sliding plate has a drip outlet in the middle, and clamping block grooves with opposite inclination directions are provided on both sides of the drip outlet. The top of the clamping block cooperates with the clamping block groove. The adjustment mechanism includes a threaded guide rod that fits into the side wall of the sliding plate. An inverted T-shaped groove is provided on the housing. The threaded guide rod passes through the T-shaped groove and engages with the adjustment knob. Rotating the adjustment knob enables the sliding plate to move laterally, and the two clamping blocks move closer or further apart through the clamping block groove.

2. The device for microneedle patch injection and peeling according to claim 1, characterized in that, The bottom opening of the housing includes an outer shell, which is inverted and U-shaped. Side baffles are connected to both sides of the outer shell, and the sliding groove is provided on the side baffles.

3. The device for microneedle patch injection and peeling according to claim 2, characterized in that, The spring guide rod has a T-shaped cross-section. Its bottom rod-shaped structure passes through the outer shell and is sleeved with the spring push rod. Its top plate-shaped structure is supported by the top surface of the outer shell. A solution channel is provided inside the spring guide rod, and the top of the solution channel is connected to an end cap.

4. The device for microneedle patch injection and peeling according to claim 1, characterized in that, The drip outlet is located on the axis of the solution channel, and the threaded guide rod is set perpendicular to the slide rail.

5. The device for microneedle patch injection and peeling according to claim 1, characterized in that, The clamping mechanism, spring guide rod, and spring push rod are located on the same axis.

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