An amide extraction resin material, a preparation method and application thereof

Abstract

The amide extraction resin material disclosed in this invention is composed of a solid support material and ligands loaded thereon. The solid support material is a polyacrylate resin, and the structural formula of the ligands loaded thereon is as follows: This invention also discloses a method for preparing the above-mentioned amide extraction resin material and its applications. The extraction resin material disclosed in this invention has a loose and porous surface with uniform particles, exhibiting excellent adsorption and desorption kinetics, and can rapidly achieve… 99m TcO4 ‑ The adsorption and desorption of anions significantly shortens the concentration time and avoids the effects of... 99m The short half-life of Tc radionuclides leads to a decrease in their radioactivity, which is detrimental to their diagnostic imaging applications in human tissues, organs, and even lesions. The amide extraction resin material disclosed in this invention is simple, mature to prepare, and easy to control and industrialize.

Description

Technical Field

[0001] This invention belongs to the technical field of materials for the separation and purification of radionuclides, as well as their preparation and application. Specifically, it relates to an amide extraction resin, its preparation method, and its application. This extraction resin material can be used for concentrated gel-type... 99 Mo- 99m Technetium-99m in the eluent from the Tc generator. Background Technology

[0002] Technetium-99m( 99m Tc nuclides have a short half-life of only 6.02 hours, and emit appropriately energetic gamma rays (E) during their decay process. γ =140.5keV), which can be widely used for diagnostic imaging of human tissues, organs, and even lesions, such as myocardial perfusion imaging, myocardial metabolism imaging, cerebral blood flow perfusion imaging, bone imaging, and tumor imaging. In the global field of nuclear medicine diagnostic imaging, compared with other diagnostic drugs, 99m Tc radionuclide drugs are used most frequently, up to 30 million times per year, providing more than 85% of nuclear medicine diagnostics. In the United States, 99m Tc has the largest usage, accounting for about 44% of the world's total, followed by Europe at 22%, Japan at 12%, and Canada at 4%.

[0003] because 99m Tc is molybdenum-99 ( 99 The daughter nuclide of Mo, and the parent nuclide 99 The half-life of Mo (66 hours) is greater than 99m Tc, during decay process 99 Mohe 99m Tc can achieve a temporary equilibrium of radioactive decay, which provides 99m Favorable conditions were provided for the preparation of Tc. Currently, 99m Tc mainly through 99 Mo- 99m Tc generator acquisition. Commercialization. 99 Mo- 99m There are two main types of Tc generators: fission type. 99 Mo- 99m Tc generator and gel type 99 Mo- 99m Tc generator. Fission type. 99 Mo- 99m Tc generator 99 Mo is obtained through uranium-235 ( 235 It is prepared by the fission reaction of U, and its specific activity is greater than 10000 Ci / g; gel type 99 Mo- 99m Tc generator 99 Mo is activated by reactor thermal neutrons.98 The molybdenum (Mo) was prepared with a specific activity less than 10 Ci / g. Clearly, the former has a much higher specific activity than the latter, and therefore is more widely used globally. 99 Mo- 99m Tc generators are mainly fission type.

[0004] However, preparation through highly enriched uranium-235 99 Mo is restricted by the Nuclear Non-Proliferation Treaty, while low-enriched uranium-235 is being produced. 99 Mo costs about 20% more than highly enriched uranium-235. These two methods differ in their preparation... 99 The process of separating molybdenum (Mo) is not only difficult but also generates a large amount of nuclear waste, which, if not properly disposed of, will inevitably pose a potential threat to human health and the ecological environment. Furthermore, planned reactor shutdowns for maintenance or decommissioning, as well as unplanned shutdowns due to reactor malfunctions or nuclear accidents, will all cause global [nuclear disasters / hazards]. 99 Mo / 99m Tc shortage. In contrast, thermal neutron activation 98 Mo preparation with low specific activity 99 Mo has the advantages of low nuclear waste generation and simple preparation, but its corresponding gel type 99 Mo- 99m The Tc generator, however, exists 99m Tc exhibits problems such as low elution efficiency, broad elution peaks, and large eluent volume (Zhou Sai; Li Long; Liu Yishu. Gel-type). 99 Mo- 99m Current Status of Tc Generator Research. Isotopes, 2019, 32(03), 171-177.), causing the eluent to contain... 99m The low concentration of Tc radioactivity leads to 99m The preparation of Tc-labeled drugs is difficult. Therefore, the development of novel solid-phase adsorption materials for concentration is crucial. 99m Tc eluent is used to enhance gel-type... 99 Mo- 99m The key to the performance of the Tc generator lies in its ability to generate high-performance components. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of existing gel-type... 99 Mo- 99m To address the problems existing in Tc generators, the first step is to provide an amide extraction resin material that can be used for rapid and efficient concentration. 99m Tc eluent, reduce eluent volume, improve 99m Tc radioactivity concentration.

[0006] Another object of the present invention is to provide a method for preparing the above-mentioned amide extract resin material.

[0007] Another object of the present invention is to provide the application of the above-mentioned amide-extractable resin material.

[0008] The amide extraction resin material provided by this invention is characterized in that the material is composed of a solid support material and ligands loaded thereon, and the structural formula of the ligands loaded thereon is as follows:

[0009]

[0010] The solid support material mentioned above is a polyacrylate resin, such as Amberchrom CG-71M resin, Amberchrom CG-71C resin, or Amberlite XAD-7 resin.

[0011] The preparation method of the above-mentioned amide extraction resin material provided by the present invention includes the following process steps and conditions:

[0012] 1) Soak and swell the solid support material in an organic solvent for 30-60 minutes, then sonicate it at room temperature for 10-30 minutes, filter out the solvent, and obtain the pretreated solid support material.

[0013] 2) First, dissolve the ligand in an organic solvent to obtain a ligand solution with a concentration of 14-72 mmol / L. Then, add the pretreated solid support material, stir and mix, and sonicate for 30-60 minutes. Then, rotate and oscillate at room temperature for 1-6 hours at a speed of 10-50 rpm to ensure that the ligand is completely immersed in the pores of the solid support material.

[0014] 3) The amide extract resin material can be obtained by drying to remove the organic solvent.

[0015] The solid support material mentioned in the above method is a polyacrylate resin, specifically Amberchrom CG-71M resin, Amberchrom CG-71C resin, or Amberlite XAD-7 resin.

[0016] The organic solvent mentioned in the above methods is methanol, ethanol, or acetone.

[0017] The ligand mentioned in the above method is N,N-diethyl-N',N',N”,N”-tetraoctylazinetriacetamide.

[0018] The mass ratio of the solid support material to the ligand in the above method is 2-10, preferably 5-8.

[0019] The application of the above-mentioned amide extract resin material provided by the present invention is for concentrated gel-type... 99 Mo- 99m Tc generator 99m Tc eluent.

[0020] The amide extraction resin material provided by this invention is used for concentrated gel-type... 99 Mo- 99m The specific method for treating the eluent in the Tc generator is as follows:

[0021] 1) The amide extraction resin is packed into a chromatography column to obtain an extraction resin column;

[0022] 2) The dilute hydrochloric acid solution was fed into the above extraction resin column at a flow rate of 0.5-2.0 mL / min to obtain the activated extraction resin column;

[0023] 3) Gel type 99 Mo- 99m Tc generator rinse 99m Tc eluent is fed into the activated extraction resin column at a flow rate of 0.5-2.0 mL / min, and the eluent is collected. 99m Tc adsorption process;

[0024] 4) Flow the alkaline solution into the resin column at a flow rate of 0.5-2.0 mL / min, and collect the effluent. 99m Tc desorption process.

[0025] The specific application methods described above 99m The chemical form of Tc is Na. 99m TcO4 can be used for organ perfusion imaging or, after reduction, can be labeled on small molecules, peptides, and antibodies as targeted diagnostic drugs.

[0026] The concentration of the dilute hydrochloric acid mentioned in the above method is 1.0-10 mmol / L.

[0027] The alkaline solution mentioned in the above methods is a sodium carbonate or sodium hydroxide solution.

[0028] The concentration of the alkaline solution mentioned in the above method is 0.10-100 mmol / L.

[0029] Compared with the prior art, the present invention has the following advantages:

[0030] 1. Because the branched chain of the nitrogen-containing triacetamide extractant molecule provided by this invention is composed of 4 n-octyl substituents and 2 ethyl substituents, compared with the branched chain composed of 6 n-octyl substituents or 4 n-octyl substituents and 2 butyl substituents, its steric hindrance is smaller, thus being beneficial in aqueous phase. 99m TcO4 - Anions are transferred and adsorbed onto the solid support material.

[0031] 2. Because the amide extraction resin material provided by this invention has a loose and porous surface and uniform particles, it possesses excellent adsorption kinetics properties, thus enabling rapid adsorption. 99m TcO4 - This greatly shortens the concentration time and avoids the effects of... 99m The short half-life of Tc nuclides leads to a decrease in their radioactivity.

[0032] 3. Because the ligands of the amide extraction resin material provided by this invention contain tertiary amine nitrogen atoms, they will undergo protonation (NH4+) in hydrochloric acid solution. + ) and form cation-anion pairs with chloride ions [NH + ]·[Cl - ], making pertechnetate ( 99m TcO4 - ) can interact with Cl - Rapid anion exchange occurs, making it easier to adsorb onto the extraction resin, resulting in high adsorption efficiency.

[0033] 4. Due to the adsorption properties of the amide extraction resin material provided by this invention... 99m TcO4 - The driving force is the protonation of its ligands in hydrochloric acid solution; therefore, by neutralizing the protons with an alkaline solution, it can be quickly converted into hydrogen. 99m TcO4 - The material can be desorbed and used as soon as possible for diagnostic imaging of human tissues, organs, or even lesions.

[0034] 5. Because the amide extraction resin material provided by this invention does not require acidity adjustment of the eluent before adsorption and elution, only pretreatment of the extraction resin column with dilute hydrochloric acid solution is needed to quickly adsorb and elute the eluent. 99m TcO4 - It is adsorbed onto the extraction resin, making it more convenient to use.

[0035] 6. Since the amide extraction resin material provided by this invention contains only four elements, C, H, O and N, it can be completely incinerated after disposal, and basically does not generate secondary solid waste, which is very environmentally friendly.

[0036] 7. Because the amide extraction resin material provided by this invention is simple and mature to prepare, it is easy to control and carry out industrial production. Attached Figure Description

[0037] Figure 1 Field emission scanning electron microscope (FESEM) images of the amide extraction resin material provided by the present invention. As can be seen from Figures (a) and (b), the resin material consists of spherical particles of very uniform size with a porous and loose surface.

[0038] Figure 2The nitrogen adsorption-desorption isotherms of the resin and amide-extractable resin materials provided by this invention are shown in the figure. As can be seen from the figure, the specific surface area and pore volume of the resin decrease after loading the amide ligand, indicating that the amide ligand has successfully entered the pores of the resin.

[0039] Figure 3 The Fourier transform infrared spectrum of the amide extractable resin material provided by this invention is shown in the figure. It can be seen from the figure that the amide extractable resin material exhibits high activity at 2859, 2931, and 2963 cm⁻¹. -1 The stretching vibration of the carbon-hydrogen bond (CH) was observed at 1643 cm⁻¹. -1 and 1150cm -1 Stretching vibrations of the carbon-oxygen double bond (C=O) and carbon-nitrogen single bond (CN) of the amide functional group were observed at the specified locations. These characteristic adsorption peaks are all attributed to the vibrations of the amide ligand functional groups, indicating that the amide ligands have been successfully loaded onto the resin material.

[0040] Figure 4 Thermogravimetric curve of the amide extraction resin material provided by the present invention. The figure shows that the material exhibits excellent thermal stability at temperatures below 272°C.

[0041] Figure 5 The adsorption-desorption elution curve of the amide extraction resin material provided by the present invention, wherein c0 in the figure represents gel type. 99 Mo- 99m The radioactivity concentration of the Tc generator eluent, where c represents the radioactivity concentration of the column effluent (Na+). 99m The radioactivity concentration of TcO4 is expressed in Bq / mL. The graph shows that during the desorption phase, Na... 99m TcO4 was mainly present in 3 mL of eluent, indicating that 10 mL of eluent was concentrated at least 3 times and the recovery rate was 85% or higher.

[0042] Figure 6 The adsorption-desorption elution curve of the amide extraction resin material provided by the present invention, wherein c0 in the figure represents gel type. 99 Mo- 99m The radioactivity concentration of the Tc generator eluent, where c represents the radioactivity concentration of the column effluent (Na+). 99m The radioactivity concentration of TcO4 is expressed in Bq / mL. The graph shows that during the desorption phase, Na... 99m TcO4 was mainly present in 3 mL of eluent, indicating that 10 mL of eluent was concentrated at least 3 times and the recovery rate reached 82% or higher.

[0043] Figure 7 The adsorption-desorption elution curve of the amide extraction resin material provided by the present invention, wherein c0 in the figure represents gel type. 99Mo- 99m The radioactivity concentration of the Tc generator eluent, where c represents the radioactivity concentration of the column effluent (Na+). 99m The radioactivity concentration of TcO4 is expressed in Bq / mL. The graph shows that during the desorption phase, Na... 99m TcO4 was mainly present in 3 mL of eluent, indicating that 10 mL of eluent was concentrated at least 3 times and the recovery rate was 80% or higher. Detailed Implementation

[0044] The following embodiments are provided to further illustrate the present invention. It should be noted that the following embodiments should not be construed as limiting the scope of protection of the present invention. If those skilled in the art make some non-essential improvements and adjustments to the present invention based on the above description, they shall still fall within the scope of protection of the present invention.

[0045] It is worth noting that, 1) the ligands used in the embodiments and comparative embodiments of this application were all prepared according to the method reported in the literature (Li, L.; Hu, X.; Wang, Z.; et al. Structure-activity relationship approach toward the improved separation of actinides(III) over lanthanides(III) using amine-triamide ligands. Sep. Purif. Technol., 2024, 330, 125545-125557.), specifically N,N-diethyl-N',N',N”,N”-tetraoctylazinetriacetamide (L I N,N-dibutyl-N',N',N”,N”-tetraoctylazinetriacetamide (L II ) and N,N,N',N',N”,N”-hexoctylazinetriacetamide (L III 1) These three nitrogen-containing triacetamide ligands. 2) To investigate the effects of these three prepared ligands on... 99m The extraction ability of Tc, the inventors of this application prepared the above-mentioned ligand L I L II and L III Dissolved separately in n-dodecane to obtain an extractable organic phase with a concentration of 5 mmol / L, and then reacted with the extract containing... 99m Equal volumes of an aqueous solution of Tc (pH 2.0) were mixed and stirred at 500 rpm for 30 minutes at room temperature using a magnetic stirrer. The organic and aqueous phases were then removed and measured separately. 99m The radioactivity concentration of Tc in the organic and aqueous phases 99m The ratio of the radioactive concentrations of Tc is the partition coefficient. The results show that L...I L II and L III The allocation coefficients are 18.5, 14.6, and 11.2, respectively. Clearly, L... I The largest partition coefficient indicates the strongest extraction ability; therefore, this invention selects N,N-diethyl-N',N',N”,N”-tetraoctylazinetriacetamide (L... I ) as the ligand in the technical solution of this application. 3) The solid support materials used in the following examples are all commercially available, of which Amberchrom CG-71M and Amberchrom CG-71C resins are produced by DuPont, Inc., USA, and Amberlite XAD-7 is produced by Acros Organics, Inc., USA.

[0046] Example 1

[0047] Five grams of commercially available Amberchrom CG-71M resin were soaked and swollen in 50 ml of methanol for 30 minutes, then sonicated at room temperature for 30 minutes. The solvent was removed by filtration to obtain the pretreated solid support material. One gram of the self-made N,N-diethyl-N',N',N”,N”-tetraoctyltriacetamide ligand was dissolved in 50 ml of methanol to make the ligand concentration 29 mmol / L. Then, the pretreated solid support material Amberchrom CG-71M was added and stirred. The mixture was sonicated for 30 minutes and then rotated at room temperature for 6 hours at 50 rpm to ensure that the ligand was completely immersed in the pores of the solid support material. The organic solvent was removed by drying to obtain 5.5 grams (92%) of amide extraction resin material.

[0048] The above materials were analyzed by field emission scanning electron microscopy, nitrogen adsorption-desorption isotherms, and Fourier transform infrared spectroscopy, which showed that the ligands were successfully loaded onto the macroporous resin (see attached figure). Figure 1 , Figure 2 , Figure 3 The material is spherical with a porous surface, indicating a large specific surface area and pore volume. Additionally, the thermogravimetric curve of this material (…) Figure 4 This indicates that it has excellent thermal stability at temperatures below 272℃.

[0049] Example 2

[0050] Five grams of commercially available Amberchrom CG-71M solid support material were soaked and swollen in 50 ml of ethanol for 60 minutes. The mixture was then sonicated at room temperature for 10 minutes, and the solvent was removed by filtration to obtain the pretreated solid support material. One gram of the self-made N,N-diethyl-N',N',N”,N”-tetraoctyltriacetamide ligand was dissolved in 50 ml of ethanol to achieve a ligand concentration of 29 mmol / L. The pretreated solid support material Amberchrom CG-71M was then added and stirred. The mixture was sonicated for 60 minutes and then rotated at room temperature for 1 hour at 10 rpm to ensure complete ligand penetration into the pores of the solid support material. The organic solvent was removed by drying to obtain 5.4 grams (92%) of amide extraction resin material.

[0051] Example 3

[0052] Five grams of commercially available Amberlite XAD-7 solid support material were soaked and swollen in 50 ml of acetone for 45 minutes, then sonicated at room temperature for 25 minutes. The solvent was removed by filtration to obtain the pretreated solid support material. Two 2.5 grams of the self-made N,N-diethyl-N',N',N”,N”-tetraoctyltriacetamide ligand were dissolved in 50 ml of ethanol to a ligand concentration of 72 mmol / L. The pretreated solid support material Amberlite XAD-7 was then added and stirred. The mixture was sonicated for 40 minutes and then rotated at room temperature for 3 hours at 30 rpm to ensure the ligand was completely immersed in the pores of the solid support material. The organic solvent was removed by drying to obtain 6.9 grams (92%) of amide extraction resin material.

[0053] Example 4

[0054] Five grams of commercially available Amberchrom CG-71C solid support material were soaked and swollen in 50 ml of methanol solvent for 60 minutes. After ultrasonic treatment at room temperature for 30 minutes, the solvent was removed by filtration to obtain the pretreated solid support material. 0.5 grams of the self-made N,N-diethyl-N',N',N”,N”-tetraoctyltriacetamide ligand was dissolved in 50 ml of acetone solvent to a ligand concentration of approximately 14 mmol / L. The pretreated solid support material Amberchrom CG-71C was then added and stirred. After ultrasonic treatment for 30 minutes, the mixture was rotated at room temperature for 3 hours at 50 rpm to ensure complete ligand penetration into the pores of the solid support material. The organic solvent was removed by drying to obtain 4.9 grams (89%) of amide extraction resin material.

[0055] Application Example 1

[0056] 1) Accurately weigh 50 mg of the amide extraction resin prepared in Example 1 and place it in a chromatography column to obtain a fully packed extraction resin column; 2) Flow 10 mL of a 1.0 mmol / L dilute hydrochloric acid solution into the extraction resin column at a flow rate of 0.5 mL / min to obtain an activated extraction resin column; 3) [The text abruptly ends here, likely due to an incomplete sentence or missing information.] 99 Mo- 99m The Tc generator produced a 10 ml rinsing volume. 99m Tc eluent is fed into the activated extraction resin column at a flow rate of 1.0 mL / min, and the eluent is collected. 99m TcO4 - Anions are adsorbed onto the extraction resin; 4) A 10 mmol / L sodium hydroxide solution (20 mL) is introduced into the extraction resin column at a flow rate of 1.0 mL / min, and an equal volume of effluent is collected. 99m TcO4 - It desorbed from the resin column.

[0057] After adsorption and desorption 99m The Tc effluent was measured using a gamma spectroscopy instrument. 99m The radioactive concentration of Tc (in Bq / mL) was obtained from the attached... Figure 5 The adsorption-desorption elution curves are shown. From these curves, it can be seen that during the desorption stage... 99m Tc was mainly present in 3 ml of eluent, indicating that 10 ml of... 99m The Tc eluent was concentrated at least three times, and the recovery rate reached 85% or higher.

[0058] Application Example 2

[0059] 1) Accurately weigh 50 mg of the amide extraction resin prepared in Example 3 and place it in a chromatography column to obtain a fully packed extraction resin column; 2) Flow 10 mL of a 10 mmol / L dilute hydrochloric acid solution into the above extraction resin column at a flow rate of 1.0 mL / min to obtain an activated extraction resin column; 3) [The text abruptly ends here, likely due to an incomplete sentence or missing information.] 99 Mo- 99m The Tc generator produced a 10 ml rinsing volume. 99m Tc eluent is fed into the activated extraction resin column at a flow rate of 0.5 mL / min, and the eluent is collected. 99m TcO4 - Anions are adsorbed onto the extraction resin; 4) A 20 mL solution of 100 mmol / L sodium carbonate is introduced into the resin column at a flow rate of 2.0 mL / min, and an equal volume of effluent is collected. 99m TcO4 - Anions desorb from the resin column.

[0060] After adsorption and desorption 99m The Tc effluent was measured using a gamma spectroscopy instrument. 99m The radioactive concentration of Tc (in Bq / mL) was obtained from the attached... Figure 6 The adsorption-desorption elution curves are shown. From these curves, it can be seen that during the desorption stage... 99m Tc was mainly present in 3 ml of eluent, indicating that 10 ml of... 99m The Tc eluent was concentrated at least three times, and the recovery rate reached 82% or higher.

[0061] Application Example 3

[0062] 1) Accurately weigh 50 mg of the amide extraction resin prepared in Example 4 and place it in a chromatography column to obtain a fully packed extraction resin column; 2) Flow 10 mL of a 5.0 mmol / L dilute hydrochloric acid solution into the extraction resin column at a flow rate of 1.0 mL / min to obtain an activated extraction resin column; 3) [The text abruptly ends here, likely due to an incomplete sentence or missing information.] 99 Mo- 99m The Tc generator produced a 10 ml rinsing volume. 99m Tc eluent was flowed into the activated extraction resin column at a flow rate of 2.0 mL / min, and the eluent was collected. 99m TcO4 - Anions are adsorbed onto the extraction resin; 4) A 0.10 mmol / L sodium hydroxide solution (20 mL) is added to the resin column at a flow rate of 0.5 mL / min, and the effluent is collected in equal volumes. 99m TcO4 - Desorbed from the resin column;

[0063] After adsorption and desorption 99m The Tc effluent was measured using a gamma spectroscopy instrument. 99m The radioactive concentration of Tc (in Bq / mL) was obtained from the attached... Figure 7 The adsorption-desorption elution curves are shown. From these curves, it can be seen that during the desorption stage... 99m Tc was mainly present in 3 ml of eluent, indicating that 10 ml of... 99m The Tc eluent was concentrated at least three times, and the recovery rate reached 80% or more.

Claims

1. An amide-extractable resin material, characterized in that... This material consists of a solid support material and ligands loaded thereon. The solid support material is a polyacrylate resin, and the structural formula of the ligands loaded thereon is as follows: 。 2. The amide extraction resin material according to claim 1, characterized in that... The polyacrylate resins mentioned in this material are Amberchrom CG-71M resin, Amberchrom CG-71C resin, or Amberlite XAD-7 resin.

3. A method for preparing the amide extraction resin material according to claim 1 or 2, wherein the process steps and conditions of the method are as follows: 1) The solid support material is soaked and swollen in an organic solvent for 30-60 minutes, then sonicated at room temperature for 10-30 minutes, and the solvent is removed by filtration to obtain the pretreated solid support material. 2) First, dissolve the ligand in an organic solvent to obtain a ligand solution with a concentration of 14–72 mmol / L. Then, add the pretreated solid support material and stir to mix. Sonicate the mixture for 30–60 minutes, and then rotate and oscillate at room temperature for 1–6 hours at a speed of 10–50 rpm to ensure that the ligand is completely immersed in the pores of the solid support material. 3) The amide extraction resin material can be obtained by drying to remove the organic solvent. The solid support material mentioned above is a polyacrylate resin.

4. The method for preparing the amide extraction resin material according to claim 3, characterized in that... The solid support material in this method is a polyacrylate resin; the ligand is... N , N -diethyl- N' , N' , N'' , N'' -Tetraoctylnitrotriacetamide; and the mass ratio of the solid support material to the ligand is 2−10.

5. The method for preparing the amide-extractable resin material according to claim 4, characterized in that... The polyacrylate resin mentioned in this method is Amberchrom CG-71M resin, Amberchrom CG-71C resin, or Amberlite XAD-7 resin.

6. The method for preparing the amide extraction resin material according to any one of claims 3-5, characterized in that... The organic solvent used in this method is methanol, ethanol, or acetone.

7. The application of the amide-extractable resin material according to any one of claims 1 or 2, characterized in that... This application is for concentrated gel types. 99 Mo- 99m Tc generator 99m The solid support material of the amide extraction resin used in the Tc eluent is a polyacrylate resin.

8. The application of the amide-extractable resin material according to claim 7, characterized in that... The application described is for concentrated gel types 99 Mo- 99m The specific method for treating the eluent in the Tc generator is as follows: 1) The amide extraction resin is packed into a chromatography column to obtain an extraction resin column; 2) A dilute hydrochloric acid solution was fed into the above extraction resin column at a flow rate of 0.5–2.0 mL / min to obtain an activated extraction resin column; 3) Gel type 99 Mo- 99m Tc generator rinse 99m Tc eluent was flowed into the activated extraction resin column at a flow rate of 0.5–2.0 mL / min, and the effluent was collected. 99m Tc adsorption process; 4) Flow the alkaline solution into the resin column at a flow rate of 0.5–2.0 mL / min, and collect the effluent. 99m Tc desorption process.

9. The application of the amide-extractable resin material according to claim 8, characterized in that... The concentration of the dilute hydrochloric acid used in this application is 1.0–10 mmol / L; the alkaline solution is a sodium carbonate or sodium hydroxide solution with a concentration of 0.10–100 mmol / L.

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