A degassing container and filling system for high-viscosity liquids

Abstract

A high-viscosity liquid degassing container and filling system include: a liquid storage container for containing liquid, with a liquid outlet at the bottom; a piston plate detachably connected to the liquid storage container, the piston plate being movably disposed within the liquid storage container to push the liquid out through the liquid outlet; a first cover detachably connected to the liquid storage container, the first cover having a vent for degassing and / or pushing the piston plate; and a protective shell for housing the liquid storage container, the protective shell having an opening for placing the liquid storage container, and an opening at the bottom of the protective shell that can connect to the liquid outlet. The centrifugal container of this invention can be used in both centrifuges and filling systems, retaining the advantages of high efficiency in centrifugal degassing, and solving the technical problems of potential bubble generation and operational difficulties during liquid transport. Furthermore, the protective shell reduces the weight of the liquid storage container, effectively increasing the amount of liquid processed by the centrifuge at one time and improving work efficiency.

Description

Technical Field

[0001] This invention relates to the field of liquid filling technology, and more particularly to degassing containers and filling systems for high-viscosity liquids. Background Technology

[0002] The size of air bubbles in the filling of high-viscosity pharmaceutical solutions is a crucial performance indicator for equipment. Existing high-viscosity pharmaceutical solutions undergo defoaming treatment before filling. Defoaming methods include vacuuming the filling system to remove air bubbles, which is convenient but time-consuming, typically one to two hours; and centrifugation, which is quick, taking only a few minutes. However, the centrifuged solution needs to be transferred to the filling system's storage container, which is cumbersome due to its high viscosity and generates air bubbles during the transfer process.

[0003] Therefore, pharmaceutical companies urgently need a defoaming filling method that has a short defoaming time and is easy to operate. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a defoaming container and filling system for high viscosity liquids with short defoaming time and convenient operation.

[0005] To solve the above technical problems, the present invention adopts the following technical solution: a degassing container for high-viscosity liquids, comprising:

[0006] A liquid storage container for holding liquid, with a liquid outlet at the bottom;

[0007] A piston plate is detachably connected to the liquid storage container. The piston plate is movably disposed inside the liquid storage container to push the liquid out of the outlet.

[0008] The first cover is detachably connected to the liquid storage container, and the first cover is provided with a vent for degassing and / or pushing the piston plate;

[0009] A protective shell for accommodating a liquid storage container, the protective shell having an opening for placing the liquid storage container, and an opening at the bottom of the protective shell for connecting to a liquid outlet.

[0010] The liquid storage container, piston plate, first cover, and protective shell can all be detachably installed. When centrifugation is required, the liquid storage container is filled with the liquid, the first cover is closed, and the container is placed in the centrifuge. During centrifugation, a vacuum pump evacuates the centrifuge, and the air inside the liquid storage container is discharged through the vent of the first cover. Vacuuming improves degassing efficiency. After degassing, the liquid storage container is removed from the centrifuge, the piston plate is added to the container, and the container is fixed to the protective shell. The outlet at the bottom of the container is opened and connected to the filling system pipeline. This method prevents the generation of air bubbles during transport. Furthermore, due to the protective shell, the strength of the liquid storage container is not a concern during the process of pushing the piston plate to discharge the liquid. The container can be made of a relatively low-strength but relatively lightweight material. As a result, due to the light weight of the container, a larger amount of liquid can be processed in one centrifugation cycle. Since the centrifuge has a maximum centrifugation weight, the weight to be centrifuged must not exceed the maximum centrifugation weight.

[0011] Furthermore, the liquid storage container and the first cover are made of plastic, while the protective outer shell is made of metal. Plastic is lightweight, while metal is strong.

[0012] Furthermore, the outlet and / or opening are equipped with a connector for connection to a pipeline and an openable / closable valve body. During centrifugation, the valve body closes to prevent the liquid from flowing out of the outlet at the bottom; when used in a filling system, the connector can be quickly connected to the pipeline of the filling system, such as a clamp.

[0013] Furthermore, the outlet at the bottom of the liquid storage container is a constricted outlet, which facilitates the discharge of the liquid from the outlet. Also, the thickness of the bottom of the liquid storage container is greater than the thickness of the side wall, and the force on the bottom is greater than that on the side wall.

[0014] Furthermore, the piston plate is provided with an exhaust port for degassing. The piston plate can be added to the liquid storage container in advance during centrifugation. After centrifugation, only the liquid storage container needs to be transferred. There is no need to open the first cover, which reduces the risk of contamination, reduces the operation after degassing, and reduces the possibility of generating bubbles.

[0015] Furthermore, it includes a second cover, which is detachably connected to the liquid storage container or protective shell. The first cover can be made of a relatively lightweight material and is used during centrifugation. However, a second cover needs to be added during filling to ensure the overall strength during filling and pressurization.

[0016] A high-viscosity liquid filling system includes a filling needle, a pump, a dispensing assembly, and a protective housing. The protective housing houses a liquid storage container. The filling needle and pump are connected via a pipeline. The pump has a pipeline that connects to the liquid storage container. The dispensing assembly works in conjunction with the pump to deliver the liquid from the storage container to the filling needle. In the filling system, the filling needle, pump, dispensing assembly, and protective housing are all mounted on a filling machine. During filling, a liquid storage container is placed inside the protective housing. The storage container is connected to the pump body via a pipeline, and the dispensing assembly is connected to the storage container.

[0017] Furthermore, the liquid pushing component is either an air blowing component or a linear drive, and the air blowing component pushes the piston plate to move by applying pressure.

[0018] Furthermore, the liquid storage container is provided with a second cover.

[0019] Furthermore, the protective outer shell is provided with a second cover, and the liquid storage container is provided with a first cover.

[0020] Compared with the prior art, the advantages of the present invention are as follows: the centrifugal container of the present invention can be used in both centrifuges and filling systems, retaining the advantages of high efficiency in centrifugation and degassing, and solving the technical problems of possible bubble generation and cumbersome operation during drug transfer. Furthermore, the protective shell reduces the weight of the storage container, effectively increasing the amount of drug that the centrifuge can process at one time and improving work efficiency. Attached Figure Description

[0021] Figure 1 —A schematic diagram of the present invention used for degassing in a centrifuge;

[0022] Figure 2 —A cross-sectional view of the present invention during degassing;

[0023] Figure 3 —A second cross-sectional view of the present invention during degassing;

[0024] Figure 4 —A cross-sectional view of the present invention during filling;

[0025] Figure 5 —A partial cross-sectional view of the present invention during filling;

[0026] Figure 6 —Diagram of the filling system of this invention.

[0027] The labels in the diagram represent: 1-liquid storage container; 11-liquid outlet; 12-connector; 13-valve body; 2-piston plate; 21-vent; 3-first cover; 31-vent; 4-protective shell; 41-opening; 5-second cover; 6-filling needle; 7-pump; 8-liquid pushing assembly. Detailed Implementation

[0028] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0029] Reference Figures 1-6 A high-viscosity liquid degassing container includes: a liquid storage container 1 for containing liquid, with a liquid outlet 11 at the bottom; a piston plate 2 detachably connected to the liquid storage container 1, which is movably disposed within the liquid storage container 1 to push the liquid out of the liquid outlet 11; a first cover 3 detachably connected to the liquid storage container 1, with a vent 31 on the first cover 3 for degassing and / or pushing the piston plate 2; and a protective shell 4 for containing the liquid storage container 1, with an opening 41 on the protective shell 4 for placing the liquid storage container 1, and an opening 41 at the bottom of the protective shell 4 that can be connected to the liquid outlet 11.

[0030] The liquid storage container 1, piston plate 2, first cover 3, and protective shell 4 can all be detachably installed. When centrifugation is required, the liquid storage container 1 is filled with the liquid, the first cover 3 is closed, and it is placed in the centrifuge. During centrifugation, the vacuum pump 7 evacuates the centrifuge, and the air in the liquid storage container 1 is discharged through the vent 31 of the first cover 3. Vacuuming can improve the degassing efficiency. After degassing, the liquid storage container 1 is removed from the centrifuge, the piston plate 2 is added to the liquid storage container 1, and the liquid storage container 1 is fixed to the protective shell 4. The liquid outlet 11 at the bottom of the liquid storage container 1 is opened and connected to the filling system pipeline. This way, no air bubbles are generated during transport. Furthermore, during the entire process, due to the protective shell 4, there is no need to worry about the strength of the liquid storage container 1 when pushing the piston plate 2 to discharge the liquid. The liquid storage container 1 can be made of a material with relatively low strength but relatively light weight. Thus, during centrifugation, because the liquid storage container 1 is light in weight, a larger amount of liquid can be processed in one centrifugation. Since the centrifuge has a maximum centrifugation weight, the weight to be centrifuged cannot exceed the maximum centrifugation weight.

[0031] The liquid storage container 1 and the first cover 3 are made of plastic, while the protective outer shell 4 is made of metal. Plastic is lightweight, while metal is strong. In other embodiments, the first cover 3 is made of metal, the piston plate 2 is made of plastic, the piston plate 2 is placed in the liquid storage container 1 during centrifugal degassing, and the first cover 3 provides protection during filling.

[0032] The outlet 11 and / or opening 41 are provided with a connector 12 for connection to a pipeline and an openable and closable valve body 13. During centrifugation, the valve body 13 is closed to prevent the liquid from flowing out of the outlet 11 at the bottom. When used in a filling system, the connector 12 can be quickly connected to the pipeline of the filling system, such as with a clamp.

[0033] The outlet 11 at the bottom of the liquid storage container 1 is a constricted opening, which facilitates the discharge of the liquid from the outlet 11. Furthermore, the bottom thickness of the liquid storage container 1 is greater than the sidewall thickness, resulting in greater stress on the bottom compared to the sidewalls. In other embodiments, the protective outer shell 4 can be manufactured into a container that conforms to the shape of the liquid storage container 1.

[0034] The piston plate 2 is provided with an exhaust port 21 for degassing. The piston plate 2 can be added to the liquid storage container 1 in advance during centrifugation. After centrifugation, only the liquid storage container 1 needs to be transferred. There is no need to open the first cover 3, which reduces the risk of contamination, reduces the operation after degassing, and reduces the possibility of generating bubbles.

[0035] It also includes a second cover 5, which is detachably connected to the liquid storage container 1 or the protective shell 4. The first cover 3 can be made of a relatively lightweight material and is used during centrifugation. When filling, the second cover 5 needs to be added to ensure the overall strength during filling and pressurization. The second cover 5 is made of metal.

[0036] A sealing ring is provided between the first cover 3 and the liquid storage container 1, and a sealing ring is also provided on the side of the piston plate 2. The second cover 5 is connected to the protective shell 4 by bolts. The liquid storage container 1 and the protective shell 4 are cylinders with a top opening 41. The piston plate 2 is circular and can pass through the top opening 41 of the liquid storage container 1.

[0037] A high-viscosity liquid filling system includes a filling needle 6, a pump 7, a liquid pushing assembly 8, and a protective housing 4. The protective housing 4 houses a liquid storage container 1. The filling needle 6 and the pump 7 are connected via a pipeline. The pump 7 has a pipeline that can connect to the liquid storage container 1. The liquid pushing assembly 8 works with the pump 7 to deliver the liquid medicine in the liquid storage container 1 to the filling needle 6. In the filling system, the filling needle 6, pump 7, liquid pushing assembly 8, and protective housing 4 are all mounted on a filling machine. During filling, the liquid storage container 1 is housed inside the protective housing 4. The liquid storage container 1 is connected to the pump 7 via a pipeline, and the liquid pushing assembly 8 is connected to the liquid storage container 1.

[0038] The liquid pushing component 8 is either an air blowing component or a linear drive. The air blowing component pushes the piston plate 2 to move by applying pressure, while the linear drive is a cylinder or the like.

[0039] While the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the invention. Any person skilled in the art can make many possible variations and modifications to the technical solutions of the present invention, or modify them into equivalent embodiments, without departing from the scope of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention, without departing from the scope of the present invention, should fall within the protection scope of the present invention.

Claims

1. A degassing container for high-viscosity liquids, characterized in that, include: A liquid storage container (1) is used to hold liquid, and a liquid outlet (11) is provided at the bottom of the liquid storage container (1). Piston plate (2) is detachably connected to liquid storage container (1). Piston plate (2) is movably disposed in liquid storage container (1) to push liquid out from liquid outlet (11). The first cover (3) is detachably connected to the liquid storage container (1), and the first cover (3) is provided with a vent (31) for degassing and / or pushing the piston plate (2). The protective shell (4) is used to accommodate the liquid storage container (1). The protective shell (4) has an opening for placing the liquid storage container (1), and the bottom of the protective shell (4) has an opening (41) that can be connected to the liquid outlet (11).

2. The high-viscosity liquid degassing container according to claim 1, characterized in that: The liquid storage container (1) and the first cover (3) are made of plastic, and the protective shell (4) is made of metal.

3. The high-viscosity liquid degassing container according to claim 1, characterized in that: The outlet (11) and / or opening (41) are provided with a connector (12) for connection to a pipeline and an openable and closable valve body (13).

4. The high-viscosity liquid degassing container according to claim 1, characterized in that: The liquid outlet (11) at the bottom of the liquid storage container (1) is a constricted outlet.

5. The high-viscosity liquid degassing container according to claim 1, characterized in that: The piston plate (2) is provided with an exhaust port (21) for degassing.

6. The high-viscosity liquid degassing container according to claim 1, characterized in that: It includes a second cover (5), which is detachably connected to the liquid storage container (1) or the protective shell (4).

7. A high-viscosity liquid filling system, characterized in that: The device includes an injection needle (6), a pump (7), a liquid pushing assembly (8), and a high-viscosity liquid degassing container as described in any one of claims 1 to 6. The protective shell (4) is used to accommodate the liquid storage container (1). The injection needle (6) and the pump (7) are connected by a pipeline. The pump (7) is provided with a pipeline that can be connected to the liquid storage container (1). The liquid pushing assembly (8) is used to cooperate with the pump (7) to deliver the liquid medicine in the liquid storage container (1) to the injection needle (6).

8. A high-viscosity liquid filling system according to claim 7, characterized in that: The liquid pushing component (8) is either an air blowing component or a linear drive.

9. A high-viscosity liquid filling system according to claim 7, characterized in that: The liquid storage container (1) is provided with a second cover (5).

10. A high-viscosity liquid filling system according to claim 7, characterized in that: The protective shell (4) is provided with a second cover (5), and the liquid storage container (1) is provided with a first cover (3).

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