A micro-pill preparation device and preparation method based on automatic roundness adjustment compensation

Abstract

The present invention discloses a micro-pill preparation device and preparation method based on automatic roundness adjustment compensation, belonging to the technical field of micro-pill preparation, comprising a preparation body, a feeding cavity is arranged on the top, a discharging cavity is arranged on the bottom, a vibration device is arranged inside, a material dividing device is arranged inside the feeding cavity, comprising a rotating column rotatably connected with the preparation body, the vibration device comprises a vibration plate, the material dividing device divides the blank pill cores transported into the feeding cavity, the blank pill cores are subjected to micro-pill preparation treatment in the preparation body, so that the drug powder is attached to the outer wall of the blank pill core, after being treated by the preparation body, the blank pill cores form micro-pills, and then the micro-pills move to the side close to the vibration device, the vibration device shakes off the drug powder that is not bonded to the surface of the micro-pills, and then the unbonded drug powder is separated from the surface of the micro-pills and transported to the preparation body again for adhesion treatment. The present invention is applied to the micro-pill production of pharmaceutical capsule preparations, which can improve the micro-pill preparation quality and drug powder utilization rate.

Description

Technical Field

[0001] The invention relates to the technical field of micro-pill preparation, and in particular to a micro-pill preparation device and a preparation method based on automatic roundness adjustment and compensation. Background Art

[0002] Micropellets are spherical or quasi-spherical solid dosage forms with a diameter of 0.5 to 1.0 mm. They can also be loaded into capsules, compressed into tablets, or made into other preparations. Micropellets are a multi-unit oral dosage form. Usually, a single dose of the drug consists of dozens to hundreds of small pellets. They can be made into different types of micropellets such as sustained-release and enteric-coated micropellets. Common micropellet preparation processes include extrusion spheronization, hot-melt extrusion (spheronization), spherical agglomeration, condensation granulation, freeze-drying granulation, powder layering, etc. Capsules such as clarithromycin sustained-release capsules, ibuprofen sustained-release capsules, doxycycline hydrochloride capsules, and gliclazide sustained-release capsules are all micropellet products;

[0003] The existing micro-pill preparation device cannot adjust the roundness of the micro-pills during the micro-pill production process, which leads to differences in the shapes of the micro-pills, thereby affecting the quality of micro-pill production. Summary of the invention

[0004] The object of the present invention is to provide a micro-pill preparation device and preparation method based on automatic adjustment and compensation of roundness, so as to solve the problems raised in the above-mentioned background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A pellet preparation device based on automatic roundness adjustment and compensation comprises: a preparation body, a feeding cavity is arranged above the preparation body, a discharging cavity is arranged below the preparation body, a material distribution device is arranged in the feeding cavity, a vibration device is arranged in the preparation body, the material distribution device comprises: a rotating column, the rotating column is rotatably connected to the preparation body, and the vibration device comprises: a vibration plate;

[0007] The staff transports the blank pill cores into the feed chamber, and then the controller controls the dividing device to start. The dividing device divides the blank pill cores transported into the feed chamber, and transports the divided blank pill cores through the feed chamber to the preparation body. The blank pill cores are then processed for micro-pellets in the preparation body, so that the drug powder adheres to the outer wall of the blank pill core. After being processed by the preparation body, the blank pill cores form micro-pellets, and then the micro-pellets move to the side close to the vibration device. When the micro-pellets fall on the surface of the vibration device, the vibration device shakes off the drug powder that is not adhered to the surface of the micro-pellets, and then the unadhered drug powder is detached from the surface of the micro-pellets, and then transported to the preparation body again for adhesion treatment.

[0008] Preferably, a No. 1 motor is provided in the preparation body, a driving shaft of the No. 1 motor is connected to a rotating column, a dispersion plate and a blocking plate are provided on the rotating column, the dispersion plate is located above the blocking plate, and the blocking plate is located on a side of the dispersion plate close to the preparation body.

[0009] Preferably, a plurality of flow grooves are provided between the dispersion plate and the blocking plate, the plurality of flow grooves are arranged around the axis of the rotating column, the flow grooves are connected to the rotating column through a bracket, the flow grooves are rotatably connected to the feed chamber, the flow grooves are spiral-shaped, the side of the flow grooves away from the preparation body is arc-shaped, and a slope is provided on the top of the dispersion plate.

[0010] Preferably, the preparation body consists of an inner column and an outer ring, the outer ring is arranged outside the inner column, and a plurality of processing tubes are arranged at the junction of the inner column and the outer ring. The plurality of processing tubes are arranged around the axis of the preparation body, and the number of the processing tubes is equal to the number of the flow grooves.

[0011] Preferably, a cleaning chamber, a bonding chamber and an adhesion chamber are arranged inside the inner column from top to bottom; an air pump No. 1 is arranged in the cleaning chamber, and a plurality of nozzles are arranged on the inner wall of the processing tube. The air pump No. 1 is connected to the nozzles through pipelines, and the nozzles are inclined toward the side close to the feed chamber.

[0012] Preferably, a section of the processing tube near the bonding cavity is provided with a plurality of delivery ports, a pressure block is provided in the delivery port, a micro spring is provided between the pressure block and the delivery port, a delivery path is provided in the pressure block, the delivery port is connected to the bonding cavity through a pipeline, the bonding cavity is filled with adhesive, the adhesion cavity is filled with drug powder, a section of the processing tube near the adhesion cavity is provided with a plurality of spray ports, a delivery pump is provided in the adhesion cavity, the delivery pump is connected to the spray ports through a pipeline, and abrasive particles are provided on the inner wall of the section of the processing tube near the adhesion cavity.

[0013] Preferably, a movable groove is provided on the inner wall of the discharge chamber, the vibration plate is slidably connected to the movable groove, a plurality of vibration springs are provided on the top and bottom of the vibration plate, the plurality of vibration springs are arranged around the axis of the vibration plate, and the other end of the vibration spring is connected to the side wall of the movable groove.

[0014] Preferably, a cavity is provided on the vibration plate, a No. 2 air pump is provided in the cavity, a plurality of output ports are further provided on the vibration plate, the plurality of output ports are arranged around the axis of the vibration plate, a plurality of filter holes are provided on the inner wall of the output port, the filter holes are connected with the cavity, a bellows is provided between the vibration plate and the preparation body, one end of the bellows is connected with the No. 2 air pump, and the other end of the bellows is connected with the adhesion cavity through a pipeline, and a spiral plate is provided in the discharge cavity;

[0015] A preparation method of a micro-pellet preparation device based on automatic roundness adjustment compensation,

[0016] The preparation method comprises the following specific steps:

[0017] S1, transporting the blank pellet core to the feeding chamber;

[0018] S2, the flow channel diverts the blank pellets;

[0019] S3, the blank pellets after diversion flow in the treatment tube;

[0020] S4, blank pellet cores are sequentially cleaned, bonded, and adhered;

[0021] S5, grinding the blank pellet cores with drug powder adhered thereto to form micropellets;

[0022] S6. The pellets are output to the discharge chamber.

[0023] Before the blank pill core is conveyed to the feed chamber, the controller controls the No. 1 motor to start, and the driving shaft of the No. 1 motor drives the rotating column to rotate, and the rotating column drives the dispersion plate and the blocking plate to rotate. When the blank pill core enters the feed chamber, since the top of the dispersion plate is provided with an inclined surface, and the dispersion plate generates centrifugal force when it rotates, the blank pill core rolls from the center of the dispersion plate to the edge of the dispersion plate. When the blank pill core moves to the edge of the dispersion plate, the blank pill core immediately rolls into the flow groove. Since the diameter of the flow groove is equal to the diameter of the blank pill core, when the blank pill core flows on the flow groove, only one blank pill core is allowed to pass, and due to the restriction of the blocking plate, the blank pill core can only move along the flow groove;

[0024] When the blank pill core moves from the top of the flow groove to the bottom of the flow groove, the blank pill core moves to the bottom of the feed chamber, and then the blank pill core moves under the driving action of the flow groove, and then the blank pill core passes through the flow groove into the processing tube;

[0025] Before the blank pill core enters the processing tube, the controller controls the No. 1 air pump to start, and the No. 1 air pump extracts air. The air is transported by the No. 1 air pump and transported to the nozzle in the processing tube through the pipeline. Since the nozzle is inclined to the side close to the feed chamber, the gas ejected from the nozzle flows in the processing tube. The gas flows from the processing tube to the feed chamber. During the gas flow, the gas cleans the surface of the blank pill core and blows away the impurities on the surface of the blank pill core, thereby improving the cleanliness of the surface of the blank pill core, thereby improving the quality of subsequent drug powder adhesion;

[0026] Since the diameter of the blank pill core is smaller than the diameter of the processing tube, and the space of the processing tube can only allow one blank pill core to pass through, the blank pill core is cleaned by the gas in turn; the cleaned blank pill core moves to a section of the processing tube close to the bonding cavity, and when the blank pill core moves to the section of the processing tube, the blank pill core encounters a pressing block during the movement, and the blank pill core pushes the pressing block, and the pressing block moves to the side close to the conveying port, and the pressing block drives the conveying path to move when the pressing block moves, and when the pressing block shrinks into the conveying port, the conveying path is connected with the conveying port, and the adhesive is then conveyed to the conveying path through the conveying port, and finally conveyed to the processing tube through the conveying path, and the blank pill core contacts with the adhesive when moving, and the adhesive is adhered to the surface of the blank pill core, and then the blank pill core with the adhesive attached is conveyed to the side close to the adhesion cavity;

[0027] During the transportation of the blank pill core, the controller controls the delivery pump to start, the delivery pump extracts the drug powder and delivers it to the spray port through the pipeline, the drug powder is sprayed to the processing tube through the spray port, and when the blank pill core is transported to the processing tube close to one side of the adhesion chamber, the sprayed drug powder is immediately adhered to the surface of the blank pill core, and the sprayed drug powder is continuously adhered to the surface of the blank pill core to form micro-pills, so that the drug powder wrapped in the blank pill core is continuously increased, and the diameter of the micro-pill is continuously increased, so that the diameter of the micro-pill is equal to the diameter of the processing tube, and the micro-pill continues to move along the processing tube after adhesion, and because abrasive particles are arranged in the processing tube, the micro-pill contacts the abrasive particles when moving, so that the abrasive particles grind the surface of the micro-pill, thereby improving the roundness of the micro-pill, thereby improving the preparation quality of the micro-pill, and the micro-pills after grinding are dropped onto the vibration plate through the processing tube;

[0028] Since the vibration plate is slidably connected along the moving groove, and a vibration spring is arranged between the vibration plate and the moving groove, the micro-pills fall on the surface of the vibration plate, causing the vibration plate to vibrate and shake, and the vibration plate transmits the vibration and shaking to the surface of the micro-pills, thereby causing the drug powder that is not completely adhered to the surface of the micro-pills to fall off, and then the micro-pills with the drug powder falling off are transported to the discharge chamber through the output port, and then the micro-pills move along the spiral plate in the discharge chamber, and then the spiral plate presses the surface of the micro-pills, further improving the quality of micro-pill preparation, and finally discharged through the discharge chamber;

[0029] While the micro-pellets are being output, the controller starts the No. 2 air pump, which extracts the gas in the discharge chamber. The gas in the discharge chamber is then transported together with the detached drug powder. The gas mixed with the drug powder is transported into the cavity through the filter holes. Then the gas mixed with the drug powder moves to the adhesion chamber through the bellows, thereby realizing the recovery of the drug powder, reducing the waste of the drug powder, and improving the utilization rate of the drug powder.

[0030] Compared with the prior art, the beneficial effects achieved by the present invention are:

[0031] 1. During the transportation of the blank pill core, the controller controls the delivery pump to start, the delivery pump extracts the drug powder and delivers it to the spray port through the pipeline, the drug powder is sprayed to the processing tube through the spray port, and when the blank pill core is transported to the processing tube close to the side of the adhesion chamber, the sprayed drug powder is immediately adhered to the surface of the blank pill core. Since the sprayed drug powder continuously adheres to the surface of the blank pill core, micro-pills are formed, so that the drug powder wrapped in the blank pill core continues to increase, and then the diameter of the micro-pills continues to increase, so that the diameter of the micro-pills is equal to the diameter of the processing tube. After adhesion, the micro-pills continue to move along the processing tube. Since abrasive particles are arranged in the processing tube, the micro-pills contact the abrasive particles when moving, so that the abrasive particles grind the surface of the micro-pills, thereby improving the roundness of the micro-pills, thereby improving the preparation quality of the micro-pills.

[0032] 2. While the micro-pellets are being output, the controller starts the No. 2 air pump, which extracts the gas in the discharge chamber. The gas in the discharge chamber is then mixed with the detached drug powder for transportation. The gas mixed with the drug powder is transported to the cavity through the filter holes, and then the gas mixed with the drug powder moves to the adhesion chamber through the bellows, thereby realizing the recovery of the drug powder, thereby reducing the waste of drug powder and improving the utilization rate of drug powder. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0034] Figure 1 is a stereogram of the present invention;

[0035] Figure 2 It is a schematic diagram of the internal structure of the present invention;

[0036] Figure 3 is a schematic diagram of the structure of the prepared body;

[0037] Figure 4 It is a structural schematic diagram of a material distribution device;

[0038] Figure 5 is a schematic diagram of the structure of the vibration device;

[0039] Figure 6 It is a schematic diagram of the structure of the conveying port and the briquetting;

[0040] Figure 7 is a cross-sectional view of the conveying port and the briquette;

[0041] In the figure: 1, preparation body; 11, feeding chamber; 12, discharging chamber; 13, inner column; 14, outer ring; 15, processing tube; 16, cleaning chamber; 17, bonding chamber; 171, conveying port; 172, pressing block; 173, conveying channel; 18, adhesion chamber;

[0042] 2. material distribution device; 21. rotating column; 22. dispersion plate; 23. blocking plate; 24. flow trough;

[0043] 3. Vibration device; 31. Vibration plate; 32. Moving groove; 33. Cavity; 34. Delivery port; 341. Filter hole; 35. Bellows. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] See also Figure 1-Figure 7 , the present invention provides a technical solution:

[0046] A pellet preparation device based on automatic roundness adjustment compensation comprises: a preparation body 1, a feed chamber 11 is arranged above the preparation body 1, a discharge chamber 12 is arranged below the preparation body 1, a material distribution device 2 is arranged in the feed chamber 11, a vibration device 3 is arranged in the preparation body 1, the material distribution device 2 comprises: a rotating column 21, the rotating column 21 is rotatably connected to the preparation body 1, and the vibration device 3 comprises: a vibration plate 31.

[0047] As a specific embodiment of the present invention, a No. 1 motor is provided in the preparation body 1, and the driving shaft of the No. 1 motor is connected to the rotating column 21. A dispersion plate 22 and a blocking plate 23 are provided on the rotating column 21. The dispersion plate 22 is located above the blocking plate 23, and the blocking plate 23 is located on the side of the dispersion plate 22 close to the preparation body 1.

[0048] As a specific embodiment of the present invention, a plurality of flow grooves 24 are arranged between the dispersion plate 22 and the blocking plate 23, and the plurality of flow grooves 24 are arranged around the axis of the rotating column 21. The flow grooves 24 are connected to the rotating column 21 through a bracket, and the flow grooves 24 are rotatably connected to the feed chamber 11. The flow grooves 24 are spiral-shaped, and the side of the flow grooves 24 away from the preparation body 1 is arc-shaped, and the top of the dispersion plate 22 is provided with an inclined surface.

[0049] As a specific embodiment of the present invention, the preparation body 1 is composed of an inner column 13 and an outer ring 14, the outer ring 14 is arranged outside the inner column 13, and a plurality of processing tubes 15 are arranged at the intersection of the inner column 13 and the outer ring 14. The plurality of processing tubes 15 are arranged around the axis of the preparation body 1, and the number of the processing tubes 15 is equal to the number of the flow grooves 24.

[0050] As a specific embodiment of the present invention, the interior of the inner column 13 is provided with a cleaning chamber 16, a bonding chamber 17 and an adhesion chamber 18 from top to bottom; a No. 1 air pump is provided in the cleaning chamber 16, and a plurality of nozzles are provided on the inner wall of the processing tube 15. The No. 1 air pump is connected to the nozzle through a pipeline, and the nozzle is inclined toward the side close to the feed chamber 11.

[0051] As a specific embodiment of the present invention, a section of the processing tube 15 near the bonding chamber 17 is provided with a plurality of delivery ports 171, a pressure block 172 is provided in the delivery port 171, a micro spring is provided between the pressure block 172 and the delivery port 171, a delivery path 173 is provided in the pressure block 172, the delivery port 171 is connected to the bonding chamber 17 through a pipeline, the bonding chamber 17 is filled with adhesive, the adhesion chamber 18 is filled with drug powder, a section of the processing tube 15 near the adhesion chamber 18 is provided with a plurality of spray ports, a delivery pump is provided in the adhesion chamber 18, the delivery pump is connected to the spray port through a pipeline, and abrasive particles are provided on the inner wall of the section of the processing tube 15 near the adhesion chamber 18.

[0052] As a specific embodiment of the present invention, a movable groove 32 is arranged on the inner wall of the discharge chamber 12, and the vibration plate 31 is slidably connected to the movable groove 32. A plurality of vibration springs are arranged on the top and bottom of the vibration plate 31, and the plurality of vibration springs are arranged around the axis of the vibration plate 31, and the other end of the vibration spring is connected to the side wall of the movable groove 32.

[0053] As a specific embodiment of the present invention, a cavity 33 is provided on the vibration plate 31, and a No. 2 air pump is provided in the cavity 33. A plurality of output ports 34 are also provided on the vibration plate 31, and the plurality of output ports 34 are arranged around the axis of the vibration plate 31. A plurality of filter holes 341 are provided on the inner wall of the output port 34, and the filter holes 341 are connected to the cavity 33. A bellows 35 is provided between the vibration plate 31 and the preparation body 1, and one end of the bellows 35 is connected to the No. 2 air pump, and the other end of the bellows 35 is connected to the adhesion chamber 18 through a pipeline. A spiral plate is provided in the discharge chamber 12.

[0054] A method for preparing a pellet preparation device based on automatic roundness adjustment and compensation, the preparation method comprising the following specific steps:

[0055] S1, conveying blank pellet cores to the feeding chamber 11;

[0056] S2, flow channel 24 diverts the blank pellet cores;

[0057] S3, the blank pellets after diversion flow in the processing tube 15;

[0058] S4, blank pellet cores are sequentially cleaned, bonded, and adhered;

[0059] S5, grinding the blank pellet cores with drug powder adhered thereto to form micropellets;

[0060] S6. The pellets are output to the discharge chamber 12.

[0061] Working principle of the present invention:

[0062] Before the blank pill core is conveyed to the feed chamber 11, the controller controls the No. 1 motor to start, and the driving shaft of the No. 1 motor drives the rotating column 21 to rotate. When the rotating column 21 rotates, it drives the dispersion plate 22 and the blocking plate 23 to rotate. When the blank pill core enters the feed chamber 11, since the top of the dispersion plate 22 is provided with an inclined surface, and the dispersion plate 22 generates centrifugal force when it rotates, the blank pill core rolls from the center of the dispersion plate 22 to the edge of the dispersion plate 22. When the blank pill core moves to the edge of the dispersion plate 22, the blank pill core immediately rolls into the flow groove 24. Since the diameter of the flow groove 24 is equal to the diameter of the blank pill core, when the blank pill core flows on the flow groove 24, only one blank pill core is allowed to pass. Due to the restriction of the blocking plate 23, the blank pill core can only move along the flow groove 24.

[0063] When the blank pill core moves from the top of the flow groove 24 to the bottom of the flow groove 24, the blank pill core moves to the bottom of the feed chamber 11, and then the blank pill core moves under the driving action of the flow groove 24, and then the blank pill core passes through the flow groove 24 into the processing tube 15;

[0064] Before the blank pill core enters the processing tube 15, the controller controls the No. 1 air pump to start, and the No. 1 air pump extracts air. The air is transported by the No. 1 air pump and transported to the nozzle in the processing tube 15 through the pipeline. Since the nozzle is inclined to the side close to the feed chamber 11, the gas ejected from the nozzle flows in the processing tube 15. The gas flows from the processing tube 15 to the feed chamber 11. During the flow of the gas, the gas cleans the surface of the blank pill core and blows away the impurities on the surface of the blank pill core, thereby improving the cleanliness of the surface of the blank pill core, thereby improving the quality of subsequent drug powder adhesion;

[0065] Since the diameter of the blank pill core is smaller than the diameter of the processing tube 15, and the space of the processing tube 15 can only allow one blank pill core to pass through, the blank pill cores are cleaned by the gas in turn; the cleaned blank pill core moves to a section of the processing tube 15 close to the bonding chamber 17, and when the blank pill core moves to the section of the processing tube 15, the blank pill core encounters the pressing block 172 during the movement, and the blank pill core pushes the pressing block 172, and the pressing block 172 moves to the side close to the delivery port 171, and the pressing block 172 drives the delivery path 173 to move when the pressing block 172 moves, and when the pressing block 172 shrinks into the delivery port 171, the delivery path 173 is connected with the delivery port 171, and the adhesive is then transported to the delivery path 173 through the delivery port 171, and finally transported to the processing tube 15 through the delivery path 173, and the blank pill core contacts with the adhesive when moving, and the adhesive is adhered to the surface of the blank pill core, and then the blank pill core with the adhesive attached is transported to the side close to the adhesion chamber 18;

[0066] During the transportation of the blank pill core, the controller controls the transportation pump to start, and the transportation pump extracts the drug powder and transports it to the spray port through the pipeline. The drug powder is sprayed to the processing tube 15 through the spray port. When the blank pill core is transported to the processing tube 15 close to the adhesion chamber 18, the sprayed drug powder is immediately adhered to the surface of the blank pill core. Since the sprayed drug powder is continuously adhered to the surface of the blank pill core, micro-pills are formed, so that the drug powder wrapped in the blank pill core is continuously increased, and the diameter of the micro-pill is continuously increased, so that the diameter of the micro-pill is equal to the diameter of the processing tube 15. After adhesion, the micro-pill continues to move along the processing tube 15. Since abrasive particles are arranged in the processing tube 15, the micro-pill contacts the abrasive particles when moving, so that the abrasive particles grind the surface of the micro-pill, thereby improving the roundness of the micro-pill, thereby improving the preparation quality of the micro-pill, and the micro-pill after grinding is dropped onto the vibration plate 31 through the processing tube 15;

[0067] Since the vibration plate 31 is slidably connected along the moving groove 32, and a vibration spring is arranged between the vibration plate 31 and the moving groove 32, the pellets fall on the surface of the vibration plate 31, causing the vibration plate 31 to vibrate and shake, and the vibration plate 31 transmits the vibration and shaking to the surface of the pellets, thereby causing the drug powder that is not completely adhered to the surface of the pellets to fall off, and then the pellets with the drug powder falling off are transported to the discharge chamber 12 through the output port 34, and then the pellets move along the spiral plate in the discharge chamber 12, and then the spiral plate presses the surface of the pellets, further improving the quality of the pellet preparation, and finally discharged through the discharge chamber 12;

[0068] While the pellets are being output, the controller controls the second air pump to start, and the second air pump extracts the gas in the discharge chamber 12, and the gas in the discharge chamber 12 is then mixed with the fallen drug powder for transportation, and the gas mixed with the drug powder is transported to the cavity 33 through the filter hole 341, and then the gas mixed with the drug powder moves to the adhesion chamber 18 through the bellows 35. The present invention is applied to the production of pellets of pharmaceutical capsule preparations, thereby realizing the recovery of drug powder, thereby reducing the waste of drug powder, and thereby improving the utilization rate of drug powder.

[0069] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0070] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A pellet preparation device based on automatic roundness adjustment and compensation, characterized in that: include: A preparation body (1), wherein a feed chamber (11) is arranged above the preparation body (1), and a discharge chamber (12) is arranged below the preparation body (1). A material distribution device (2) is arranged in the feed chamber (11), and a vibration device (3) is arranged in the preparation body (1). The material distribution device (2) comprises: a rotating column (21), and the rotating column (21) is rotatably connected to the preparation body (1). The vibration device (3) comprises: a vibration plate (31); A first motor is arranged in the preparation body (1), a driving shaft of the first motor is connected to a rotating column (21), a dispersion plate (22) and a blocking plate (23) are arranged on the rotating column (21), the dispersion plate (22) is located above the blocking plate (23), and the blocking plate (23) is located on a side of the dispersion plate (22) close to the preparation body (1); A plurality of flow grooves (24) are arranged between the dispersion plate (22) and the blocking plate (23), the plurality of flow grooves (24) are arranged around the axis of the rotating column (21), the flow grooves (24) are connected to the rotating column (21) through a bracket, the flow grooves (24) are rotatably connected to the feed chamber (11), the flow grooves (24) are spiral-shaped, and the side of the flow grooves (24) away from the preparation body (1) is arc-shaped, and the top of the dispersion plate (22) is provided with an inclined surface; The preparation body (1) is composed of an inner column (13) and an outer ring (14), wherein the outer ring (14) is arranged outside the inner column (13), and a plurality of processing tubes (15) are arranged at the intersection of the inner column (13) and the outer ring (14), and the plurality of processing tubes (15) are arranged around the axis of the preparation body (1), and the number of the processing tubes (15) is equal to the number of the flow grooves (24); The inner column (13) is provided with a cleaning chamber (16), a bonding chamber (17) and an adhesion chamber (18) from top to bottom; a No. 1 air pump is provided in the cleaning chamber (16), and a plurality of nozzles are provided on the inner wall of the processing tube (15); the No. 1 air pump is connected to the nozzles through pipelines, and the nozzles are inclined toward a side close to the feeding chamber (11); A section of the processing tube (15) near the bonding chamber (17) is provided with a plurality of delivery ports (171), a pressing block (172) is provided in the delivery port (171), a micro spring is provided between the pressing block (172) and the delivery port (171), a delivery path (173) is provided in the pressing block (172), the delivery port (171) is connected to the bonding chamber (17) through a pipeline, the bonding chamber (17) is filled with adhesive, the adhesion chamber (18) is filled with drug powder, a section of the processing tube (15) near the adhesion chamber (18) is provided with a plurality of drug spraying ports, a delivery pump is provided in the adhesion chamber (18), the delivery pump is connected to the drug spraying ports through a pipeline, and abrasive particles are provided on the inner wall of the section of the processing tube (15) near the adhesion chamber (18); A movable groove (32) is provided on the inner wall of the discharge chamber (12), the vibration plate (31) is slidably connected to the movable groove (32), a plurality of vibration springs are provided on the top and bottom of the vibration plate (31), the plurality of vibration springs are arranged around the axis of the vibration plate (31), and the other end of the vibration spring is connected to the side wall of the movable groove (32); The vibration plate (31) is provided with a cavity (33), a No. 2 air pump is provided in the cavity (33), a plurality of output ports (34) are also provided on the vibration plate (31), the plurality of output ports (34) are arranged around the axis of the vibration plate (31), a plurality of filter holes (341) are provided on the inner wall of the output port (34), the filter holes (341) are connected with the cavity (33), a bellows (35) is provided between the vibration plate (31) and the preparation body (1), one end of the bellows (35) is connected with the No. 2 air pump, and the other end of the bellows (35) is connected with the adhesion chamber (18) through a pipeline, and a spiral plate is provided in the discharge chamber (12).

2. A method for preparing a pellet preparation device based on automatic roundness adjustment and compensation as claimed in claim 1, characterized in that: The preparation method comprises the following specific steps: S1, transporting blank pellets to the feeding chamber (11); S2, the flow channel (24) diverts the blank pellet core; S3, the blank pellets after diversion flow in the processing tube (15); S4, blank pellet cores are sequentially cleaned, bonded, and adhered; S5, grinding the blank pellet cores with drug powder adhered thereto to form micropellets; S6. The pellets are output to the discharge chamber (12).

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