A high-efficiency transdermal dressing and preparation method thereof

Abstract

The invention relates to the technical field of dressings, and discloses a dressing for efficient transdermal transmission and a preparation method thereof. The invention comprises the following steps: adding quaternary ammonium salt modified silicone rubber, camellia seed oil, tocopherol, chitosan-hyaluronic acid gel, sodium hyaluronate, polyvinyl alcohol, epoxy nano-silica, poloxamer and deionized water into a stirrer, stirring the mixture, and obtaining the dressing for efficient transdermal transmission after stirring. During the stirring process, the epoxy group of the epoxy nano-silica reacts with the amino group in the chitosan, and the epoxy group forms a hydroxyl group, which further forms a hydrogen bond with the nitrogen-hydrogen bond of the quaternary ammonium salt modified silicone rubber, and is firmly adsorbed on the surface of the skin, thereby promoting the absorption of the dressing and increasing the penetration rate. The ferrocene contained in the silicone rubber can help the skin to restore smoothness and remove wrinkles. The silicone rubber has good biocompatibility, and the synergistic effect with the quaternary ammonium salt and chitosan promotes the skin care and antibacterial effects on the skin.

Description

Technical Field

[0001] The invention relates to the technical field of dressings, in particular to a dressing for efficient transdermal transmission and a preparation method thereof. Background Art

[0002] Dressing refers to auxiliary materials used in addition to the main ingredients of an item, mainly referring to hemostatic gauze. Traditional dressings are mainly dry gauze and oil gauze. Modern wound dressings include interactive wound dressings, calcium alginate dressings, silver dressings, hydrocolloid dressings and hydrogel dressings, etc. For example, patent CN115040688A discloses a medical dressing for promoting transdermal absorption of drugs and a preparation method thereof, which is applied to a medical dressing system, improves the transdermal absorption capacity of the material, and significantly improves the effect of the drug, but does not improve the antibacterial effect. Therefore, the present invention further optimizes the effect of its dressing. Summary of the invention

[0003] 1. Technical issues to be resolved

[0004] In view of the deficiencies of the prior art, the present invention provides a highly efficient transdermal dressing and a preparation method thereof, which has a good penetration rate and skin care and antibacterial effects, and promotes wound recovery.

[0005] (II) Technical solution

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a highly efficient transdermal transmission dressing, comprising the following components by weight: 2-4 parts by weight of quaternary ammonium salt modified silicone rubber, 5-10 parts by weight of camellia seed oil, 1-2 parts by weight of tocopherol, 4-5 parts by weight of chitosan-hyaluronic acid gel, 10-20 parts by weight of sodium hyaluronate, 5-12 parts by weight of polyvinyl alcohol, 4-6 parts by weight of epoxy nano-silica, 5-8 parts by weight of poloxamer, and 15-20 parts by weight of deionized water.

[0007] Preferably, the preparation method of the quaternary ammonium salt modified silicone rubber is:

[0008] (1) Add lauric acid to a reactor, heat to 60-80°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, introduce nitrogen while stirring, react at 140-170°C for 8-12 hours, cool to room temperature after reaction, and purify to obtain intermediate 1;

[0009] (2) Under nitrogen conditions, the intermediate 1 is added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane is added thereto, reacted at 50-80° C. for 3-6 hours, and the solvent is removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0010] (3) Add methanol solvent, inhibitor butylhydroxytoluene, catalyst chloroplatinic acid tetrahydrofuran solution, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinated lauric acid into the reactor, ultrasonically disperse for 30-40 minutes, then add silicone rubber, react at 60-80°C for 3-8 hours, cool, centrifuge and wash to obtain quaternary ammonium salt modified silicone rubber.

[0011] Preferably, the mass ratio of lauric acid to dimethylaminopropylamine in (1) is 1:1.1-1.3.

[0012] Preferably, the mass ratio of the intermediate 1 to vinyltrichlorosilane in (2) is 1.5-2.2:1.

[0013] Preferably, the mass ratio of the polymerization inhibitor butylated hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinated lauric acid to silicone rubber in (3) is 0.01-0.02:0.02-0.04:1:1.1-1.3:0.8-1.2.

[0014] Preferably, the preparation method of the chitosan-hyaluronic acid gel is:

[0015] S1. Add ferrocene formaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 60-90°C for 5-8h, then continue to add hydrogen-terminated dimethylsiloxane, react at 70-100°C for 7-10h, and then distill under reduced pressure, wash with ether, and recrystallize to obtain 1-modified ferrocene;

[0016] S2. Add modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, stir evenly, react at 70-100°C for 20-30h, filter, wash and dry to obtain ferrocene-modified chitosan;

[0017] S3. Add 6-8 parts by weight of ferrocene-modified chitosan and 5-7 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 2-4% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 22-26°C for 20-25h to obtain chitosan-hyaluronic acid gel.

[0018] Preferably, the mass ratio of ferrocenecarboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane in S1 is 1:1.1-1.3:0.9-1.2.

[0019] Preferably, the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan in S2 is 1.2-1.3:1:1.1-1.4.

[0020] Preferably, the preparation method of the highly efficient transdermal dressing comprises the following steps: adding quaternary ammonium salt-modified silicone rubber, camellia seed oil, tocopherol, chitosan-hyaluronic acid gel, sodium hyaluronate, polyvinyl alcohol, epoxy nano-silica, poloxamer, and deionized water into a stirrer, stirring at 20-40° C. for 25-40 minutes, and obtaining a highly efficient transdermal dressing after stirring; the dressing is in a gel state.

[0021] 3. Beneficial technical effects

[0022] The invention adds quaternary ammonium salt modified silicone rubber, camellia seed oil, tocopherol, chitosan-hyaluronic acid gel, sodium hyaluronate, polyvinyl alcohol, epoxy nano-silicon dioxide, poloxamer and deionized water into a stirrer, and stirs to obtain a dressing with high efficiency in transdermal transmission.

[0023] During the stirring process, the epoxy groups of epoxy nano-silica will react with the amino groups in chitosan, open the ring to form hydroxyl groups, and further form hydrogen bonds with the nitrogen-hydrogen bonds of the quaternary ammonium salt-modified silicone rubber, firmly adsorbing on the surface of the skin, promoting the absorption of the dressing and increasing the penetration rate; the ferrocene contained in it can help the skin restore smoothness and remove wrinkles; silicone rubber has good biocompatibility, and works synergistically with quaternary ammonium salts and chitosan to promote skin care and antibacterial effects. DETAILED DESCRIPTION

[0024] Example 1

[0025] (1) Add lauric acid to a reactor, heat to 60°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, wherein the mass ratio of lauric acid to dimethylaminopropylamine is 1:1.1, introduce nitrogen under stirring, react at 140°C for 8 hours, cool to room temperature after completion, and purify to obtain intermediate 1;

[0026] (2) Under nitrogen conditions, the intermediate 1 was added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane was added thereto, wherein the mass ratio of the intermediate 1 to vinyl trichlorosilane was 1.5:1, and the reaction was carried out at 50° C. for 3 h, and the solvent was removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0027] (3) Add methanol solvent, inhibitor dibutyl hydroxytoluene, tetrahydrofuran solution of catalyst chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically disperse for 30 minutes, and then add silicone rubber, wherein the mass ratio of inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber is 0.01:0.02:1:1.1:0.8, react at 60°C for 3 hours, cool, centrifuge and wash to obtain quaternary ammonium salt modified silicone rubber;

[0028] (4) Add ferrocene carboxaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 60°C for 5 hours, then continue to add hydrogen-terminated dimethylsiloxane, wherein the mass ratio of ferrocene carboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane is 1:1.1:0.9, react at 70°C for 7 hours, and then perform vacuum distillation after completion, wash with ether, and recrystallize to obtain modified ferrocene;

[0029] (5) adding modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, wherein the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan is 1.2:1:1.1, stirring evenly, reacting at 70°C for 20h, filtering, washing and drying to obtain ferrocene-modified chitosan;

[0030] (6) Add 6 parts by weight of ferrocene-modified chitosan and 5 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 2% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 22° C. for 20 h to obtain chitosan-hyaluronic acid gel;

[0031] (7) Add 2 parts by weight of quaternary ammonium salt-modified silicone rubber, 5 parts by weight of camellia seed oil, 1 part by weight of tocopherol, 4 parts by weight of ferrocene-modified chitosan, 10 parts by weight of sodium hyaluronate, 5 parts by weight of polyvinyl alcohol, 4 parts by weight of epoxy nanosilica, 5 parts by weight of poloxamer, and 15 parts by weight of deionized water into a blender and stir at 20°C for 25 minutes to obtain a dressing with high efficiency in transdermal transmission.

[0032] Example 2

[0033] (1) Add lauric acid to a reactor, heat to 80°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, wherein the mass ratio of lauric acid to dimethylaminopropylamine is 1:1.3, introduce nitrogen under stirring, react at 170°C for 12 hours, cool to room temperature after completion, and purify to obtain intermediate 1;

[0034] (2) Under nitrogen conditions, the intermediate 1 was added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane was added thereto, wherein the mass ratio of the intermediate 1 to vinyl trichlorosilane was 2.2:1, and the reaction was carried out at 80° C. for 6 h. The solvent was removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0035] (3) Adding methanol solvent, inhibitor dibutyl hydroxytoluene, tetrahydrofuran solution of catalyst chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically dispersing for 40 minutes, and then adding silicone rubber, wherein the mass ratio of inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber is 0.02:0.04:1:1.3:1.2, reacting at 80°C for 8 hours, cooling, centrifuging, and washing to obtain quaternary ammonium salt modified silicone rubber;

[0036] (4) Add ferrocene carboxaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 90°C for 8 hours, then continue to add hydrogen-terminated dimethylsiloxane, wherein the mass ratio of ferrocene carboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane is 1:1.3:1.2, react at 100°C for 10 hours, and then distill under reduced pressure, wash with ether, and recrystallize to obtain modified ferrocene;

[0037] (5) adding modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, wherein the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan is 1.3:1:1.4, stirring evenly, reacting at 100°C for 30h, filtering, washing and drying to obtain ferrocene-modified chitosan;

[0038] (6) Add 8 parts by weight of ferrocene-modified chitosan and 7 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 4% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 26° C. for 25 h to obtain chitosan-hyaluronic acid gel;

[0039] (7) 4 parts by weight of quaternary ammonium salt-modified silicone rubber, 10 parts by weight of camellia seed oil, 2 parts by weight of tocopherol, 5 parts by weight of ferrocene-modified chitosan, 20 parts by weight of sodium hyaluronate, 12 parts by weight of polyvinyl alcohol, 6 parts by weight of epoxy nanosilica, 8 parts by weight of poloxamer, and 20 parts by weight of deionized water are added into a blender and stirred at 40° C. for 40 min. After the stirring, a dressing with high efficiency in transdermal transmission is obtained.

[0040] Example 3

[0041] (1) Add lauric acid to a reactor, heat to 70°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, wherein the mass ratio of lauric acid to dimethylaminopropylamine is 1:1.2, introduce nitrogen under stirring, react at 155°C for 10 hours, cool to room temperature after completion, and purify to obtain intermediate 1;

[0042] (2) Under nitrogen conditions, the intermediate 1 was added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane was added thereto, wherein the mass ratio of the intermediate 1 to vinyl trichlorosilane was 1.85:1, and the reaction was carried out at 65° C. for 4.5 h. The solvent was removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0043] (3) Add methanol solvent, inhibitor dibutyl hydroxytoluene, tetrahydrofuran solution of catalyst chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically disperse for 35 minutes, and then add silicone rubber, wherein the mass ratio of inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber is 0.015:0.03:1:1.2:1.0, react at 70°C for 5.5 hours, cool, centrifuge and wash to obtain quaternary ammonium salt modified silicone rubber;

[0044] (4) Add ferrocene carboxaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 75°C for 6.5 hours, then continue to add hydrogen-terminated dimethylsiloxane, wherein the mass ratio of ferrocene carboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane is 1:1.2:1.05, react at 85°C for 8.5 hours, and then perform vacuum distillation after completion, wash with ether, and recrystallize to obtain modified ferrocene;

[0045] (5) adding modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, wherein the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan is 1.25:1:1.25, stirring evenly, reacting at 85°C for 25h, filtering, washing and drying to obtain ferrocene-modified chitosan;

[0046] (6) Add 7 parts by weight of ferrocene-modified chitosan and 6 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 3% by weight acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 24° C. for 22.5 hours to obtain chitosan-hyaluronic acid gel;

[0047] (7) Add 3 parts by weight of quaternary ammonium salt modified silicone rubber, 7.5 parts by weight of camellia seed oil, 1.5 parts by weight of tocopherol, 4.5 parts by weight of ferrocene modified chitosan, 15 parts by weight of sodium hyaluronate, 8.5 parts by weight of polyvinyl alcohol, 5 parts by weight of epoxy nano-silica, 6.5 parts by weight of poloxamer, and 17.5 parts by weight of deionized water into a blender, and stir at 30°C for 32.5 minutes to obtain a dressing with high efficiency in transdermal transmission.

[0048] Example 4

[0049] (1) Add lauric acid to a reactor, heat to 60°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, wherein the mass ratio of lauric acid to dimethylaminopropylamine is 1:1.1, introduce nitrogen under stirring, react at 140°C for 8 hours, cool to room temperature after completion, and purify to obtain intermediate 1;

[0050] (2) Under nitrogen conditions, the intermediate 1 was added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane was added thereto, wherein the mass ratio of the intermediate 1 to vinyl trichlorosilane was 1.5:1, and the reaction was carried out at 50° C. for 3 h, and the solvent was removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0051] (3) Adding methanol solvent, inhibitor dibutyl hydroxytoluene, tetrahydrofuran solution of catalyst chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically dispersing for 40 minutes, and then adding silicone rubber, wherein the mass ratio of inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber is 0.02:0.04:1:1.3:1.2, reacting at 80°C for 8 hours, cooling, centrifuging, and washing to obtain quaternary ammonium salt modified silicone rubber;

[0052] (4) Add ferrocene carboxaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 90°C for 8 hours, then continue to add hydrogen-terminated dimethylsiloxane, wherein the mass ratio of ferrocene carboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane is 1:1.3:1.2, react at 100°C for 10 hours, and then distill under reduced pressure, wash with ether, and recrystallize to obtain modified ferrocene;

[0053] (5) adding modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, wherein the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan is 1.25:1:1.25, stirring evenly, reacting at 85°C for 25h, filtering, washing and drying to obtain ferrocene-modified chitosan;

[0054] (6) Add 6 parts by weight of ferrocene-modified chitosan and 5 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 2% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 22° C. for 20 h to obtain chitosan-hyaluronic acid gel;

[0055] (7) Add 3 parts by weight of quaternary ammonium salt modified silicone rubber, 7.5 parts by weight of camellia seed oil, 1.5 parts by weight of tocopherol, 4.5 parts by weight of ferrocene modified chitosan, 15 parts by weight of sodium hyaluronate, 8.5 parts by weight of polyvinyl alcohol, 5 parts by weight of epoxy nano-silica, 8 parts by weight of poloxamer, and 17.5 parts by weight of deionized water into a blender, and stir at 30°C for 32.5 minutes to obtain a dressing with high efficiency in transdermal transmission.

[0056] Example 5

[0057] (1) Add lauric acid to a reactor, heat to 80°C to dissolve, stir evenly, then continue to add dimethylaminopropylamine, wherein the mass ratio of lauric acid to dimethylaminopropylamine is 1:1.3, introduce nitrogen under stirring, react at 170°C for 12 hours, cool to room temperature after completion, and purify to obtain intermediate 1;

[0058] (2) Under nitrogen conditions, the intermediate 1 was added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane was added thereto, wherein the mass ratio of the intermediate 1 to vinyl trichlorosilane was 2.2:1, and the reaction was carried out at 80° C. for 6 h. The solvent was removed by rotary evaporation and dried to obtain olefinated lauric acid;

[0059] (3) Add methanol solvent, inhibitor dibutyl hydroxytoluene, tetrahydrofuran solution of catalyst chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically disperse for 35 minutes, and then add silicone rubber, wherein the mass ratio of inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber is 0.015:0.03:1:1.2:1.0, react at 70°C for 5.5 hours, cool, centrifuge and wash to obtain quaternary ammonium salt modified silicone rubber;

[0060] (4) Add ferrocene carboxaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 75°C for 6.5 hours, then continue to add hydrogen-terminated dimethylsiloxane, wherein the mass ratio of ferrocene carboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane is 1:1.2:1.05, react at 85°C for 8.5 hours, and then perform vacuum distillation after completion, wash with ether, and recrystallize to obtain modified ferrocene;

[0061] (5) adding modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, wherein the mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan is 1.2:1:1.1, stirring evenly, reacting at 70°C for 20h, filtering, washing and drying to obtain ferrocene-modified chitosan;

[0062] (6) Add 7 parts by weight of ferrocene-modified chitosan and 6 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 2% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 22° C. for 20 h to obtain chitosan-hyaluronic acid gel;

[0063] (7) Add 2 parts by weight of quaternary ammonium salt-modified silicone rubber, 5 parts by weight of camellia seed oil, 1 part by weight of tocopherol, 4 parts by weight of ferrocene-modified chitosan, 10 parts by weight of sodium hyaluronate, 5 parts by weight of polyvinyl alcohol, 4 parts by weight of epoxy nanosilica, 5 parts by weight of poloxamer, and 15 parts by weight of deionized water into a blender and stir at 20°C for 25 minutes to obtain a dressing with high efficiency in transdermal transmission.

[0064] Comparative Example 1

[0065] The difference between this comparative example and Example 5 is that no quaternary ammonium salt-modified silicone rubber is added.

[0066] Comparative Example 2

[0067] The difference between this comparative example and Example 5 is that no chitosan-hyaluronic acid gel is added.

[0068] Skin care performance test: 140 volunteers were selected and divided into 7 groups of 20 people each. Each group of volunteers tried the dressing prepared by Examples 1-5 or Comparative Examples 1-2 respectively. After continuous use for 30 days, the changes in skin physiological indicators of each group were statistically analyzed.

[0069] Table 1: Skin care tests.

[0070] project Skin improvement Transepidermal water loss Example 1 Skin plumpness 18% reduction Example 2 Skin plumpness 19% reduction Example 3 Skin plumpness 18% reduction Example 4 Skin plumpness 17% reduction Example 5 Skin plumpness 18% reduction Comparative Example 1 The skin has a few wrinkles 13% reduction Comparative Example 2 The skin has a few wrinkles 11% reduction

[0071] As can be seen from Table 1, the high-efficiency transdermal dressing embodiments 1-5 of the present invention have better recovery and skin care effects than comparative examples 1-2.

[0072] An in vitro transdermal absorption experiment was conducted using an intelligent transdermal diffusion tester. 40 mg of the sample was evenly applied on the surface of rat ex vivo skin, and its penetration rate was calculated.

[0073] Table 2: Permeation rate testing.

[0074] project Permeation rate (ug / (cm2·h)) Example 1 106.18 Example 2 115.69 Example 3 112.74 Example 4 110.58 Example 5 109.84 Comparative Example 1 78.32 Comparative Example 2 72.68

[0075] As can be seen from Table 2, the high-efficiency transdermal dressing embodiments 1-5 of the present invention have better penetration rates than comparative examples 1-2, and can quickly promote wound recovery.

[0076] The dressing containing high-efficiency transdermal transmission was dissolved and cast into a film to make a thin sheet with a radius of 1 cm; then the bacteria were transferred to a sterile culture medium using an inoculation loop to culture, making a bacterial suspension with a concentration of 106 CFU / mL, and then 0.5 mL of the bacterial suspension was transferred dropwise to a culture dish containing beef extract peptone culture medium, shaken evenly and then added to the thin sheet, and cultured in a constant temperature incubator. The diameter of the inhibition zone was measured after 48 h of culture.

[0077] Table 3: Antimicrobial testing.

[0078] project Escherichia coli (mm) Staphylococcus aureus (mm) Example 1 13.5 14.9 Example 2 18.6 17.8 Example 3 16.7 16.1 Example 4 15.1 15.7 Example 5 16.5 15.9 Comparative Example 1 6.1 7.1 Comparative Example 2 6.3 6.5

[0079] As can be seen from Table 2, the high-efficiency transdermal dressing embodiments 1-5 of the present invention have better antibacterial effects than comparative examples 1-2.

[0080] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A highly efficient transdermal dressing, characterized in that: The invention comprises the following components by weight: 2-4 parts by weight of quaternary ammonium salt modified silicone rubber, 5-10 parts by weight of camellia seed oil, 1-2 parts by weight of tocopherol, 4-5 parts by weight of chitosan-hyaluronic acid gel, 10-20 parts by weight of sodium hyaluronate, 5-12 parts by weight of polyvinyl alcohol, 4-6 parts by weight of epoxy nano-silica, 5-8 parts by weight of poloxamer, and 15-20 parts by weight of deionized water; The preparation method of the quaternary ammonium salt modified silicone rubber is: (1) Add lauric acid to a reactor, heat to 60-80° C. to dissolve, stir evenly, then continue to add dimethylaminopropylamine, introduce nitrogen under stirring, react at 140-170° C. for 8-12 hours, cool to room temperature after completion, purify, and obtain intermediate 1; (2) Under nitrogen conditions, the intermediate 1 is added to an ethanol solvent, stirred and dispersed, and then vinyl trichlorosilane is added thereto, reacted at 50-80° C. for 3-6 hours, and the solvent is removed by rotary evaporation and dried to obtain olefinated lauric acid; (3) adding methanol solvent, inhibitor butylhydroxytoluene, catalyst chloroplatinic acid tetrahydrofuran solution, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to the reactor, ultrasonically dispersing for 30-40 minutes, then adding silicone rubber, reacting at 60-80° C. for 3-8 hours, cooling, centrifuging, and washing to obtain quaternary ammonium salt modified silicone rubber; The preparation method of the chitosan-hyaluronic acid gel is: S1. Add ferrocene formaldehyde and dimethylaminopropylamine to N,N-dimethylformamide solvent, react at 60-90°C for 5-8h, then continue to add hydrogen-terminated dimethylsiloxane, react at 70-100°C for 7-10h, and then distill under reduced pressure, wash with ether, and recrystallize to obtain modified ferrocene; S2. Add modified ferrocene, 2-chlorobenzyl chloride and chitosan to N,N-dimethylformamide, stir evenly, react at 70-100°C for 20-30h, filter, wash and dry to obtain ferrocene-modified chitosan; S3. Add 6-8 parts by weight of ferrocene-modified chitosan and 5-7 parts by weight of hyaluronic acid into deionized water, stir evenly, then slowly add 2-4% by weight of acetic acid, stir to dissolve, continue to add glutaraldehyde crosslinking agent, and let stand at 22-26°C for 20-25h to obtain chitosan-hyaluronic acid gel.

2. The high-efficiency transdermal dressing according to claim 1, characterized in that: The mass ratio of lauric acid to dimethylaminopropylamine in (1) is 1:1.1-1.

3.

3. The high-efficiency transdermal dressing according to claim 1, characterized in that: The mass ratio of the intermediate 1 to vinyltrichlorosilane in (2) is 1.5-2.2:

1.

4. The high-efficiency transdermal dressing according to claim 1, characterized in that: The mass ratio of the polymerization inhibitor dibutyl hydroxytoluene, chloroplatinic acid, 1-ferrocenyl-3-phenylprop-2-en-1-one and olefinic lauric acid to silicone rubber in (3) is 0.01-0.02:0.02-0.04:1:1.1-1.3:0.8-1.

2.

5. The high-efficiency transdermal dressing according to claim 1, characterized in that: The mass ratio of ferrocenecarboxaldehyde, dimethylaminopropylamine and hydrogen-terminated dimethylsiloxane in S1 is 1:1.1-1.3:0.9-1.

2.

6. The high-efficiency transdermal dressing according to claim 1, characterized in that: The mass ratio of modified ferrocene, 2-chlorobenzyl chloride and chitosan in S2 is 1.2-1.3:1:1.1-1.

4.

7. A method for preparing a highly efficient transdermal dressing as claimed in any one of claims 1 to 6, characterized in that: The preparation method of the highly efficient transdermal dressing comprises the following steps: adding quaternary ammonium salt-modified silicone rubber, camellia seed oil, tocopherol, chitosan-hyaluronic acid gel, sodium hyaluronate, polyvinyl alcohol, epoxy nano-silica, poloxamer, and deionized water into a stirrer, stirring at 20-40° C. for 25-40 minutes, and obtaining the highly efficient transdermal dressing after stirring.