Traditional Chinese medicine composition for treating pleural effusion and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating pleural effusion and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 25 parts of radix codonopsis, 10 to 20 parts of raw rhizoma atractylodis macrocephalae, 10 to 20 parts of poria cocos, 4 to 8 parts of honey-fried licorice root, 8 to 12 parts of rhizoma alismatis, 10 to 14 parts of fried semen lepidii, 8 to 12 parts of fructus ziziphi jujubae, 8 to 12 parts of fried semen brassicae, 4 to 8 parts of pericarpium citri reticulatae, 25 to 35 parts of radix astragali preparata, 15 to 25 parts of radix bupleuri, 8 to 12 parts of rhizoma pinelliae, 8 to 12 parts of rhizoma zingiberis recens, 8 to 12 parts of radix scutellariae and 15 to 21 parts of raw semen coicis. According to the traditional Chinese medicine composition for treating pleural effusion, the traditional dialectical treatment is taken as a criterion, the effects of invigorating spleen to eliminate dampness, regulating qi to relieve chest stuffiness, promoting blood circulation to remove meridian obstruction, clearing damp and promoting diuresis are achieved, monarch, minister, assistant and guide are clear, the formula is proper, and dialectical treatment and disease distinguishing are combined. The traditional Chinese medicines are used for invigorating spleen to eliminate dampness, regulating qi, relieving chest stuffiness, promoting blood circulation to dredge collaterals, clearing damp and promoting diuresis so as to improve blood circulation, promote hydrops absorption and eliminate hydrops without water drawing and drainage. The formula is particularly reliable in curative effect and obvious in effect on pathogen attacking chest and lung diseases.

Description

Technical Field

[0001] The present application relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating pleural effusion and a preparation method thereof. Background Art

[0002] Pleural effusion is a common clinical symptom, usually manifested by chest pain, dyspnea, cough and general weakness. The disease can be caused by a variety of reasons, including infection, tumors, tuberculosis, heart failure, etc. Traditional treatment methods mainly include drug therapy and surgical drainage, but these methods usually have certain side effects or operation risks, and the efficacy is not ideal. In recent years, with the development of traditional Chinese medicine, more and more studies have shown that traditional Chinese medicine has significant efficacy in the treatment of pleural effusion, with less toxic side effects.

[0003] In the prior art, there are various traditional Chinese medicine treatments for pleural effusion, but there are generally problems such as unstable efficacy and unreasonable drug formula. In addition, there is currently a lack of a traditional Chinese medicine composition that can comprehensively regulate the spleen and stomach, regulate qi and relieve chest tightness, promote blood circulation and dredge collaterals, and has a good diuretic and dampness-inducing effect on the market. Therefore, the development of a traditional Chinese medicine composition with definite efficacy, small toxic and side effects, and reasonable formula has become a topic that technicians in this field need to solve urgently. Summary of the invention

[0004] The present application solves the technical problem by adopting the following technical solution.

[0005] The embodiment of the present application provides a traditional Chinese medicine composition for treating pleural effusion, comprising the following raw materials in parts by weight: 15-25 parts of Codonopsis pilosula, 10-20 parts of raw Atractylodes macrocephala, 10-20 parts of Poria cocos, 4-8 parts of roasted Licorice root, 8-12 parts of Alisma orientalis, 10-14 parts of stir-fried Lepidium sativum seeds, 8-12 parts of jujubes, 8-12 parts of stir-fried Sinapis alba, 4-8 parts of dried tangerine peel, 25-35 parts of roasted Astragalus membranaceus, 15-25 parts of Bupleurum chinense, 8-12 parts of Pinellia ternata, 8-12 parts of ginger, 8-12 parts of Scutellaria baicalensis, and 15-21 parts of raw Coix seeds.

[0006] Furthermore, the invention comprises the following raw materials in parts by weight: 15-20 parts of Codonopsis pilosula, 10-15 parts of raw Atractylodes macrocephala, 10-15 parts of Poria cocos, 4-6 parts of roasted Licorice root, 8-10 parts of Alisma orientalis, 10-12 parts of stir-fried Lepidium sativum seeds, 8-10 parts of jujubes, 8-10 parts of stir-fried Sinapis alba seeds, 4-10 parts of dried tangerine peel, 25-30 parts of roasted Astragalus membranaceus, 15-20 parts of Bupleurum chinense, 8-10 parts of Pinellia ternata, 8-10 parts of ginger, 8-10 parts of Scutellaria baicalensis, and 15-18 parts of raw Coix seeds.

[0007] Furthermore, the invention comprises the following raw materials in parts by weight: 20-25 parts of Codonopsis pilosula, 15-20 parts of raw Atractylodes macrocephala, 15-20 parts of Poria cocos, 6-8 parts of roasted Licorice root, 10-12 parts of Alisma orientalis, 12-14 parts of stir-fried Lepidium sativum seeds, 10-12 parts of jujubes, 10-12 parts of stir-fried Sinapis alba seeds, 6-8 parts of dried tangerine peel, 30-35 parts of roasted Astragalus membranaceus, 20-25 parts of Bupleurum chinense, 10-12 parts of Pinellia ternata, 10-12 parts of ginger, 10-12 parts of Scutellaria baicalensis, and 18-21 parts of raw Coix seeds.

[0008] Further, the invention comprises the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 15 parts of raw Atractylodes macrocephala, 15 parts of Poria cocos, 6 parts of roasted Licorice root, 10 parts of Alisma orientalis, 12 parts of stir-fried Lepidium officinale seeds, 10 parts of jujube, 10 parts of stir-fried Sinapis alba, 6 parts of dried tangerine peel, 30 parts of roasted Astragalus membranaceus, 20 parts of Bupleurum chinense, 10 parts of Pinellia ternata, 10 parts of ginger, 10 parts of Scutellaria baicalensis, and 18 parts of raw Coix seeds.

[0009] The present application also provides a method for preparing a Chinese medicine composition for treating pleural effusion, which is used to prepare any of the above-mentioned Chinese medicine compositions for treating pleural effusion, and the preparation method comprises the following steps:

[0010] Step 1: Place raw materials such as Codonopsis pilosula, raw Atractylodes macrocephala, Poria cocos, roasted Licorice root, Alisma orientalis, stir-fried Lepidium tiliaceum seeds, jujube, stir-fried white mustard seeds, dried orange peel, stir-fried Astragalus membranaceus, Bupleurum chinense, Pinellia tuber, ginger, Scutellaria baicalensis, and raw Coix seeds on the screening table to remove impurities, insect-eaten parts, and other non-medicinal parts from the medicinal materials;

[0011] Step 2: Rinse the selected medicinal materials in running water to remove dust, sand and other dirt on the surface;

[0012] Step 3: Crush the medicinal materials according to their properties;

[0013] Step 4: Spread the crushed herbs flat on a drying rack and place them in a cool and ventilated environment to dry naturally or dry the crushed herbs at low temperature;

[0014] Step 5: Put the dried or baked medicinal materials into a grinder for crushing;

[0015] Step 6: Weigh and proportion the crushed medicinal materials according to any of the aforementioned Chinese medicine compositions, add them into a mixer, and mix for 10-20 minutes.

[0016] Furthermore, in the step three, the codonopsis pilosula, atractylodes macrocephala, astragalus membranaceus, and bupleurum are cut into 3-5 mm thin slices, the ginger is cut into 1-2 mm thin slices, the poria is cut into 5-10 mm thick slices, the jujube is pitted and cut into 2-3 mm thin slices, and the oriental water chestnut is cut into 2-4 mm thin slices; the pinellia and licorice are processed and cut into 3 mm thin slices; the fried scutellaria baicalensis seeds and fried white mustard seeds are crushed with a pestle and mortar; the tangerine peel is broken into blocks with a side length of 3-5 mm; the scutellaria baicalensis and coix seeds do not need to be processed.

[0017] Furthermore, in the step 4, the coix seeds and sliced ​​ginger are placed in a dryer and dried at a temperature between 40-60° C. until the moisture content drops below 10%, and the other crushed medicinal materials are spread on a drying rack and placed in a cool and ventilated environment to dry naturally.

[0018] Furthermore, the method further comprises the following steps:

[0019] Step 7: Put the evenly mixed medicinal powder into a mixer, gradually add the adhesive solution, and stir;

[0020] Step 8: The moistened soft material is squeezed through a sieve or granulator with a pore size of 2-3 mm to form granules;

[0021] Step 9: Spread the prepared wet granules evenly on a baking tray, put them into a dryer, and dry them at 50-60°C until the moisture content of the granules is less than 5%;

[0022] Step 10: Screen the dried particles, retain the qualified particles, and re-crush and granulate the unqualified particles.

[0023] Furthermore, the binder is sodium carboxymethyl cellulose, the mass concentration of the binder is 2%-5%, and the mass ratio of the binder to the medicinal material powder is 10-15%.

[0024] Furthermore, in the step 10, the dried particles are sieved through a 1.2 mm or 1.5 mm sieve.

[0025] Based on the above technical scheme, the Chinese medicine composition of the present invention makes full use of the synergistic effect of various medicinal materials through scientific and reasonable formula design, and achieves the comprehensive curative effect of strengthening the spleen and eliminating dampness, regulating qi and widening the chest, promoting blood circulation and unblocking collaterals, and promoting water and dampness. Clinical application shows that the composition can not only significantly relieve the symptoms of patients with pleural effusion, such as chest tightness, shortness of breath, pain, etc., but also promote the natural absorption of effusion, and reduce the necessity of relying on invasive treatment methods. In addition, the Chinese medicine composition is based on traditional medicinal materials with the same origin of medicine and food, has high safety, no obvious toxic and side effects, is suitable for long-term use, and has a wide range of promotion and application value. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to the conventional conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0027] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to specific embodiments.

[0028] The embodiment of the present application provides a traditional Chinese medicine composition for treating pleural effusion, comprising the following raw materials in parts by weight: 15-25 parts of Codonopsis pilosula, 10-20 parts of raw Atractylodes macrocephala, 10-20 parts of Poria cocos, 4-8 parts of roasted Licorice root, 8-12 parts of Alisma orientalis, 10-14 parts of stir-fried Lepidium sativum seeds, 8-12 parts of jujubes, 8-12 parts of stir-fried Sinapis alba, 4-8 parts of dried tangerine peel, 25-35 parts of roasted Astragalus membranaceus, 15-25 parts of Bupleurum chinense, 8-12 parts of Pinellia ternata, 8-12 parts of ginger, 8-12 parts of Scutellaria baicalensis, and 15-21 parts of raw Coix seeds.

[0029] The three herbs in the composition, namely, Codonopsis pilosula, roasted Astragalus membranaceus and Chinese jujube, play the role of replenishing Qi and strengthening the body. Codonopsis pilosula can replenish Qi and strengthen the spleen, and is a commonly used herb for patients with weak spleen and stomach, shortness of breath and fatigue, and can enhance the overall immunity of patients. Roasted Astragalus membranaceus can replenish Qi and raise Yang, consolidate the exterior and stop sweating, which can enhance the patient's disease resistance and help eliminate excess water in the body. Chinese jujube not only has the effects of replenishing the spleen and Qi, nourishing blood and calming the mind, but also can reconcile the medicinal properties, alleviate the side effects that may be caused by other drugs, and improve the patient's physical fitness.

[0030] Raw Atractylodes macrocephala, Poria cocos and raw coix seed can strengthen the spleen and eliminate dampness, and promote the excretion of dampness in the body. Raw Atractylodes macrocephala can improve the symptoms of edema caused by spleen deficiency by strengthening the spleen and eliminating dampness; Poria cocos has a significant diuretic effect while strengthening the spleen and calming the mind, helping to eliminate excess water in the body; raw coix seed, with its characteristics of clearing heat and draining pus, strengthening the spleen and eliminating dampness, further promotes the elimination of dampness in the body and improves the overall health of patients.

[0031] Bupleurum, dried tangerine peel, pinellia and ginger can regulate qi, relieve chest tightness, resolve phlegm and relieve cough. Among them, bupleurum can relieve liver qi and depression, raise yang and lift depression, effectively relieve chest and flank pain caused by liver qi stagnation, and regulate qi; dried tangerine peel regulates qi and strengthens spleen, dries dampness and resolves phlegm, and helps prevent phlegm and dampness from stagnation in the chest cavity; pinellia plays a major role in drying dampness and resolving phlegm, and can reduce adverse reactions and stop vomiting, eliminate lumps and resolve knots; ginger can resolve the exterior and dissipate cold, warm the middle and stop vomiting, strengthen the effect of regulating qi and resolving phlegm, and prevent cold and dampness from blocking the chest cavity.

[0032] Alisma, stir-fried scutellaria seeds and stir-fried white mustard seeds can clear the lungs, promote water circulation and reduce swelling. Alisma can clear away dampness and heat, and remove excess water from the body; stir-fried scutellaria seeds can help reduce the formation of pleural effusion by clearing the lungs and relieving asthma, promoting water circulation and reducing swelling; stir-fried white mustard seeds can warm the lungs and eliminate phlegm, promote qi circulation and disperse nodules, and are suitable for patients with cold phlegm blocking the lungs, further relieving the stuffy pain in the chest.

[0033] As a representative medicinal material for clearing heat and drying dampness, Scutellaria baicalensis can purge fire and detoxify, and is especially suitable for patients with symptoms of damp-heat, helping to clear phlegm and heat in the body; while roasted licorice improves the overall palatability of the prescription by invigorating qi, tonifying the middle and harmonizing various medicines, enhancing the effect of invigorating qi and moistening the lungs, ensuring that patients can use the medicine for a long time without increasing the burden on their body.

[0034] The Chinese medicine composition provided in the embodiment of the present application is a reliable formula obtained by the inventor after 20 years of clinical trials. The embodiment of the present application takes the traditional dialectical treatment as the criterion, invigorates the spleen and eliminates dampness, regulates qi and relieves chest tightness, activates blood circulation and unblocks meridians, promotes diuresis and eliminates dampness, and the monarch, minister, assistant and envoy are clearly distinguished. The formula is just right, and the dialectical treatment is combined with the disease differentiation. Chinese medicine is used to invigorate the spleen and eliminate dampness, regulate qi, relieve chest tightness, activate blood circulation and unblock meridians, promote diuresis and eliminate dampness, so as to improve blood circulation and promote the absorption of effusion, and eliminate effusion without pumping or drainage. This formula is especially effective for evil chest and lung diseases, and the effect is obvious.

[0035] Furthermore, the invention comprises the following raw materials in parts by weight: 15-20 parts of Codonopsis pilosula, 10-15 parts of raw Atractylodes macrocephala, 10-15 parts of Poria cocos, 4-6 parts of roasted Licorice root, 8-10 parts of Alisma orientalis, 10-12 parts of stir-fried Lepidium sativum seeds, 8-10 parts of jujubes, 8-10 parts of stir-fried Sinapis alba seeds, 4-10 parts of dried tangerine peel, 25-30 parts of roasted Astragalus membranaceus, 15-20 parts of Bupleurum chinense, 8-10 parts of Pinellia ternata, 8-10 parts of ginger, 8-10 parts of Scutellaria baicalensis, and 15-18 parts of raw Coix seeds.

[0036] Furthermore, the invention comprises the following raw materials in parts by weight: 20-25 parts of Codonopsis pilosula, 15-20 parts of raw Atractylodes macrocephala, 15-20 parts of Poria cocos, 6-8 parts of roasted Licorice root, 10-12 parts of Alisma orientalis, 12-14 parts of stir-fried Lepidium sativum seeds, 10-12 parts of jujubes, 10-12 parts of stir-fried Sinapis alba seeds, 6-8 parts of dried tangerine peel, 30-35 parts of roasted Astragalus membranaceus, 20-25 parts of Bupleurum chinense, 10-12 parts of Pinellia ternata, 10-12 parts of ginger, 10-12 parts of Scutellaria baicalensis, and 18-21 parts of raw Coix seeds.

[0037] Further, the invention comprises the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 15 parts of raw Atractylodes macrocephala, 15 parts of Poria cocos, 6 parts of roasted Licorice root, 10 parts of Alisma orientalis, 12 parts of stir-fried Lepidium officinale seeds, 10 parts of jujube, 10 parts of stir-fried Sinapis alba, 6 parts of dried tangerine peel, 30 parts of roasted Astragalus membranaceus, 20 parts of Bupleurum chinense, 10 parts of Pinellia ternata, 10 parts of ginger, 10 parts of Scutellaria baicalensis, and 18 parts of raw Coix seeds.

[0038] The present application also provides a method for preparing a Chinese medicine composition for treating pleural effusion, which is used to prepare any of the above-mentioned Chinese medicine compositions for treating pleural effusion, and the preparation method comprises the following steps:

[0039] Step 1: Place raw materials such as Codonopsis pilosula, raw Atractylodes macrocephala, Poria cocos, roasted Licorice root, Alisma orientalis, stir-fried Lepidium tiliaceum seeds, jujube, stir-fried white mustard seeds, dried orange peel, stir-fried Astragalus membranaceus, Bupleurum chinense, Pinellia tuber, ginger, Scutellaria baicalensis, and raw Coix seeds on the screening table to remove impurities, insect-eaten parts, and other non-medicinal parts from the medicinal materials;

[0040] Step 2: Rinse the selected medicinal materials in running water to remove dust, sand and other dirt on the surface;

[0041] Step 3: Crush the medicinal materials according to their properties;

[0042] Step 4: Spread the crushed herbs flat on a drying rack and place them in a cool and ventilated environment to dry naturally or dry the crushed herbs at low temperature;

[0043] Step 5: Put the dried or baked medicinal materials into a grinder for crushing;

[0044] Step 6: Weigh and proportion the crushed medicinal materials according to any of the aforementioned Chinese medicine compositions, add them into a mixer, and mix for 10-20 minutes.

[0045] Through this preparation method, each medicinal material is fully cleaned, screened, crushed and dried during the processing, ensuring the purity of the raw medicinal materials and the retention of the effective ingredients. The crushed medicinal materials are accurately mixed in proportion to ensure the consistency of each batch of drugs, maximize the therapeutic effect of the composition, and ensure the safety of the preparation and the stability of quality.

[0046] Furthermore, in the step three, the codonopsis pilosula, atractylodes macrocephala, astragalus membranaceus, and bupleurum are cut into 3-5 mm thin slices, the ginger is cut into 1-2 mm thin slices, the poria is cut into 5-10 mm thick slices, the jujube is pitted and cut into 2-3 mm thin slices, and the oriental water chestnut is cut into 2-4 mm thin slices; the pinellia and licorice are processed and cut into 3 mm thin slices; the fried scutellaria baicalensis seeds and fried white mustard seeds are crushed with a pestle and mortar; the tangerine peel is broken into blocks with a side length of 3-5 mm; the scutellaria baicalensis and coix seeds do not need to be processed.

[0047] By treating different medicinal materials differently, each medicinal material can release its active ingredients to the maximum extent during the processing, while maintaining the physical properties of the medicinal materials, which is conducive to the uniformity of subsequent processing and mixing. Different cutting methods for different medicinal materials can optimize the absorption and utilization of the medicinal materials and improve the overall efficacy of the composition.

[0048] Furthermore, in the step 4, the coix seeds and sliced ​​ginger are placed in a dryer and dried at a temperature between 40-60° C. until the moisture content drops below 10%, and the other crushed medicinal materials are spread on a drying rack and placed in a cool and ventilated environment to dry naturally.

[0049] By controlling the drying temperature and moisture content, the active ingredients in the medicinal materials are retained, avoiding the loss of active ingredients in the medicinal materials caused by excessively high temperatures. In addition, low-temperature drying can also prevent the medicinal materials from deteriorating or being over-dried, thereby improving the stability of the preparation and the durability of the efficacy.

[0050] Furthermore, the method further comprises the following steps:

[0051] Step 7: Put the evenly mixed medicinal powder into a mixer, gradually add the adhesive solution, and stir;

[0052] Step 8: The moistened soft material is squeezed through a sieve or granulator with a pore size of 2-3 mm to form granules;

[0053] Step 9: Spread the prepared wet granules evenly on a baking tray, put them into a dryer, and dry them at 50-60°C until the moisture content of the granules is less than 5%;

[0054] Step 10: Screen the dried particles, retain the qualified particles, and re-crush and granulate the unqualified particles.

[0055] By making the powder of medicinal materials into granules, the granules are uniform in size and have a moderate water content, which is convenient for patients to use and improves the appearance and taste of the medicine. The formation of granular dosage form not only improves the convenience of taking the medicine, but also makes the medicine easier to dissolve and absorb in the gastrointestinal tract, thereby improving the efficacy.

[0056] Furthermore, the binder is sodium carboxymethyl cellulose, the mass concentration of the binder is 2%-5%, and the mass ratio of the binder to the medicinal material powder is 10-15%.

[0057] Using sodium carboxymethyl cellulose as a binder not only improves the formability and stability of the particles, but also ensures good release of the drug in the body due to its good solubility and biocompatibility in the drug. A reasonable binder ratio ensures that the hardness of the drug particles is moderate, which is convenient for patients to swallow and avoids the discomfort caused by the particles being too hard during the administration process.

[0058] Furthermore, in the step 10, the dried particles are sieved through a 1.2 mm or 1.5 mm sieve.

[0059] The Chinese medicine composition of the present invention makes full use of the synergistic effect of various medicinal materials through scientific and reasonable formula design, and achieves the comprehensive curative effect of strengthening the spleen and eliminating dampness, regulating qi and widening the chest, promoting blood circulation and unblocking collaterals, and promoting water and removing dampness. Clinical application shows that the composition can not only significantly relieve the symptoms of patients with pleural effusion, such as chest tightness, shortness of breath, pain, etc., but also promote the natural absorption of effusion and reduce the necessity of relying on invasive treatment methods. In addition, the Chinese medicine composition is based on traditional medicinal materials with the same origin as medicine and food, has high safety, no obvious toxic and side effects, is suitable for long-term use, and has a wide range of promotion and application value.

[0060] The features and performance of the present application are further described in detail below in conjunction with the embodiments.

[0061] Example 1

[0062] In this embodiment, the raw materials are placed on a screening table to remove impurities, insect-eaten parts and other non-medicinal parts from the medicinal materials; the screened medicinal materials are rinsed in running water to remove dust, sand and other dirt on the surface, and then Codonopsis, Atractylodes, Astragalus, and Bupleurum are cut into 3 mm slices, ginger is cut into 1 mm slices, Poria is cut into 7 mm thick slices, jujube is pitted and cut into 3 mm slices, and Alisma is cut into 3 mm slices; Pinellia and Licorice are processed and cut into 3 mm slices; the fried Lepi and white mustard seeds are crushed with a pestle and mortar; the dried orange peel is broken into blocks with a side length of 4 mm; Scutellaria and Coix seeds are not processed. Process; then put the coix seeds and sliced ​​ginger into a dryer, dry them at a temperature of 50°C until the moisture content drops below 10%, spread the other crushed medicinal materials flat on a drying rack, place them in a cool and ventilated environment to dry naturally and crush them; finally weigh step six: weigh the crushed medicinal materials 15 grams of Codonopsis pilosula, 10 grams of raw Atractylodes macrocephala, 10 grams of Poria cocos, 4 grams of roasted Licorice root, 8 grams of Alisma orientalis, 10 grams of stir-fried Lepidium japonicum seeds, 8 grams of jujube, 8 grams of stir-fried white mustard seeds, 4 grams of tangerine peel, 25 grams of roasted Astragalus membranaceus, 15 grams of Bupleurum chinense, 8 grams of Pinellia ternata, 8 grams of ginger, 8 grams of Scutellaria baicalensis, 15 grams of raw coix seeds, add them into a mixer, and mix for 15 minutes.

[0063] Mash 10 grams of garlic and 10 grams of scallion into a paste. Take 2 grams of the mixed powder and mix it with the mashed garlic and scallion to make a paste. Apply it to the Shenque point. Change the dressing every 12 hours and use it continuously for 15 days.

[0064] Case 1: Ms. Han, 60 years old, local, had severe pain in the left chest and flank, fatigue, poor appetite. After relevant examinations at the local hospital, there was effusion in the left pleural cavity. She was diagnosed with exudative pleurisy. She was treated with intravenous infusion, cephalosporins, and levofloxacin for ten days in hospital, but there was no improvement and the pleural effusion did not decrease. She came to see a doctor after being introduced by a friend! The diagnosis showed pain in the left chest and flank, low fever in the afternoon, night sweats, alternating cold and heat, dry cough with little sputum, chest tightness and poor appetite, fatigue, red tongue with little coating, and weak pulse. The evil was half-exterior and half-interior. The treatment should be to reconcile Shaoyang and promote lung qi. Use 30 doses of the above with additions and subtractions according to symptoms. Completely cured, and no recurrence after one year of follow-up.

[0065] Example 2

[0066] In this embodiment, the raw materials are placed on a screening table to remove impurities, insect-eaten parts and other non-medicinal parts in the medicinal materials; the screened medicinal materials are rinsed in running water to remove dust, sand and other dirt on the surface, and then Codonopsis pilosula, Atractylodes macrocephala, Astragalus membranaceus, and Bupleurum chinense are cut into 3 mm thin slices, ginger is cut into 1 mm thin slices, Poria cocos is cut into 7 mm thick slices, jujube is pitted and cut into 3 mm thin slices, and Alisma orientalis is cut into 3 mm thin slices; Pinellia ternata and Licorice root are processed and cut into 3 mm thin slices; the fried Lepi seed and the fried White Mustard seed are crushed with a pestle and mortar; the dried orange peel is broken into blocks with a side length of 4 mm; Scutellaria baicalensis and Coix seeds do not need to be processed; then Then put the coix seeds and sliced ​​ginger into the dryer and dry them at a temperature of 50°C until the moisture content drops below 10%. Spread the other crushed medicinal materials on the drying rack and place them in a cool and ventilated environment to dry naturally and crush them. Finally, weigh the step six: weigh the crushed medicinal materials: 20 grams of Codonopsis pilosula, 15 grams of raw Atractylodes macrocephala, 15 grams of Poria cocos, 6 grams of roasted Licorice root, 10 grams of Alisma orientalis, 12 grams of stir-fried Lepidium japonicum seeds, 10 grams of jujube, 10 grams of stir-fried white mustard seeds, 6 grams of dried tangerine peel, 30 grams of roasted Astragalus membranaceus, 20 grams of Bupleurum chinense, 10 grams of Pinellia ternata, 10 grams of ginger, 10 grams of Scutellaria baicalensis, 18 grams of raw coix seeds, add them into the mixer and mix for 15 minutes.

[0067] Mash 10 grams of garlic and 10 grams of scallion into a paste. Take 3 grams of the mixed powder and mix it with the mashed scallion and garlic to make a paste. Apply it to the Shenque point. Change the dressing every 12 hours and use it continuously for 15 days.

[0068] Case 2: Mr. Li, 55 years old, suffered from chest tightness and shortness of breath for a long time, especially after fatigue, the symptoms worsened, occasionally accompanied by cough and slight fever. After examination in the hospital, he was diagnosed with exudative pleurisy. After treatment with the above-mentioned Chinese medicine composition, the symptoms gradually eased, the pleural effusion was significantly reduced, and no recurrence was observed during the six-month follow-up.

[0069] Example 3

[0070] In this embodiment, the raw materials are placed on a screening table to remove impurities, insect-eaten parts and other non-medicinal parts in the medicinal materials; the screened medicinal materials are rinsed in running water to remove dust, sand and other dirt on the surface, and then Codonopsis pilosula, Atractylodes macrocephala, Astragalus membranaceus, and Bupleurum chinense are cut into 3 mm thin slices, ginger is cut into 1 mm thin slices, Poria cocos is cut into 7 mm thick slices, jujube is pitted and cut into 3 mm thin slices, and Alisma orientalis is cut into 3 mm thin slices; Pinellia ternata and Licorice root are processed and cut into 3 mm thin slices; the fried Lepi seed and the fried White Mustard seed are crushed with a pestle and mortar; the dried orange peel is broken into blocks with a side length of 4 mm; Scutellaria baicalensis and Coix seeds do not need to be processed; then Then put the coix seeds and sliced ​​ginger into the dryer and dry them at a temperature of 50°C until the moisture content drops below 10%. Spread the other crushed medicinal materials on the drying rack and place them in a cool and ventilated environment to dry naturally and crush them. Finally, weigh the step six: weigh the crushed medicinal materials: 25 grams of Codonopsis pilosula, 20 grams of raw Atractylodes macrocephala, 20 grams of Poria cocos, 8 grams of roasted Licorice root, 12 grams of Alisma orientalis, 14 grams of stir-fried Lepidium japonicum seeds, 12 grams of jujube, 12 grams of stir-fried white mustard seeds, 8 grams of dried tangerine peel, 35 grams of roasted Astragalus membranaceus, 25 grams of Bupleurum chinense, 12 grams of Pinellia ternata, 12 grams of ginger, 12 grams of Scutellaria baicalensis, 21 grams of raw coix seeds, add them into the mixer and mix for 15 minutes.

[0071] Mash 10 grams of garlic and 10 grams of scallion into a paste. Take 4 grams of the mixed powder and mix it with the mashed garlic and scallion to make a paste. Apply it to the Shenque point. Change the dressing every 12 hours and use it continuously for 15 days.

[0072] Case 3: Ms. Wang, 70 years old, suffered from chronic bronchitis and recently developed chest pain and dyspnea, which was diagnosed as pleural effusion. After using the above Chinese medicine composition, the symptoms were significantly improved, the effusion was reduced, the quality of life was improved, and no recurrence was found during the one-year follow-up.

[0073] Comparative Example 1

[0074] In this embodiment, the raw materials are placed on a screening table to remove impurities, insect-eaten parts and other non-medicinal parts in the medicinal materials; the screened medicinal materials are rinsed in running water to remove dust, mud and other dirt on the surface, and then Codonopsis pilosula, Atractylodes macrocephala, Astragalus membranaceus, and Bupleurum chinense are cut into 3 mm thin slices, ginger is cut into 1 mm thin slices, Poria cocos is cut into 7 mm thick slices, jujube is pitted and cut into 3 mm thin slices, and Alisma orientalis is cut into 3 mm thin slices; Pinellia ternata and Licorice root are processed and cut into 3 mm thin slices; the fried Lepidium chinense and white mustard seeds are crushed with a pestle and mortar; the dried orange peel is broken into blocks with a side length of 4 mm; Scutellaria baicalensis and Coix seeds are unpeeled. Need to be processed; then put the coix seed and sliced ​​ginger into the dryer, dry at a temperature of 50°C until the moisture content drops below 10%, spread the other crushed medicinal materials on the drying rack, place them in a cool and ventilated environment to dry naturally and crush them; finally weigh step six: weigh the crushed medicinal materials Codonopsis pilosula 10 grams, raw Atractylodes macrocephala 8 grams, Poria 8 grams, roasted Licorice root 3 grams, Alisma orientalis 6 grams, stir-fried Lepi lily 8 grams, jujube 6 grams, stir-fried white mustard seed 6 grams, tangerine peel 3 grams, roasted Astragalus 20 grams, Bupleurum 10 grams, Pinellia 6 grams, ginger 6 grams, Scutellaria baicalensis 6 grams, raw coix seed 10 grams, add them into the mixer, and mix for 15 minutes.

[0075] Mash 10 grams of garlic and 10 grams of scallion into a paste. Take 2 grams of the mixed powder and mix it with the mashed garlic and scallion to make a paste. Apply it to the Shenque point. Change the dressing every 12 hours and use it continuously for 15 days.

[0076] Case 4: Mr. Zhao, 65 years old, a patient with pleural effusion, did not show significant improvement in symptoms after treatment with the formula in Comparative Example 1, and the reduction of effusion was not significant. He eventually relied on other treatment methods to control his condition.

[0077] Comparative Example 2

[0078] In this embodiment, the raw materials are placed on a screening table to remove impurities, insect-eaten parts and other non-medicinal parts from the medicinal materials; the screened medicinal materials are rinsed in running water to remove dust, sand and other dirt on the surface, and then Codonopsis pilosula, Atractylodes macrocephala, Astragalus membranaceus, and Bupleurum chinense are cut into 3 mm thin slices, ginger is cut into 1 mm thin slices, Poria cocos is cut into 7 mm thick slices, jujube is pitted and cut into 3 mm thin slices, and Alisma orientalis is cut into 3 mm thin slices; Pinellia tuber and Licorice root are processed and cut into 3 mm thin slices; the fried Lepi seed and the fried White Mustard seed are crushed with a pestle and mortar; the dried orange peel is broken into blocks with a side length of 4 mm; Scutellaria baicalensis and Coix seed do not need to be processed; then Put coix seeds and sliced ​​ginger into a dryer and dry them at a temperature of 50°C until the moisture content drops below 10%. Spread the other crushed medicinal materials on a drying rack and place them in a cool and ventilated environment to dry naturally and crush them. Finally, weigh the step six: weigh the crushed medicinal materials: 30 grams of Codonopsis pilosula, 25 grams of raw Atractylodes macrocephala, 25 grams of Poria cocos, 10 grams of roasted Licorice root, 15 grams of Alisma orientalis, 16 grams of stir-fried Lepidium sativum seeds, 15 grams of jujube, 15 grams of stir-fried white mustard seeds, 10 grams of dried tangerine peel, 40 grams of roasted Astragalus membranaceus, 30 grams of Bupleurum chinense, 15 grams of Pinellia ternata, 15 grams of ginger, 15 grams of Scutellaria baicalensis, 25 grams of raw coix seeds, add them into a mixer and mix for 15 minutes.

[0079] Mash 10 grams of garlic and 10 grams of scallion into a paste. Take 6 grams of the mixed powder and mix it with the garlic and scallion paste to make a paste. Apply it to the Shenque point. Change the dressing every 12 hours and use it continuously for 15 days.

[0080] Case 5: Ms. Sun, 58 years old, a patient with pleural effusion, developed adverse reactions such as gastrointestinal discomfort and dizziness after treatment with the formula in Comparative Example 2. The effusion did not decrease significantly, so she eventually stopped using this formula and switched to other therapies.

[0081] Compared with the prior art, the present invention has at least the following advantages or beneficial effects:

[0082] The embodiments of the present application make full use of the synergistic effect of various medicinal materials through scientific and reasonable formula design, and achieve the comprehensive curative effect of strengthening the spleen and eliminating dampness, regulating qi and widening the chest, promoting blood circulation and unblocking collaterals, and promoting water and dampness. Clinical application shows that the composition can not only significantly relieve the symptoms of patients with pleural effusion, such as chest tightness, shortness of breath, pain, etc., but also promote the natural absorption of effusion and reduce the necessity of relying on invasive treatment methods. In addition, the Chinese medicine composition is based on traditional medicinal materials with the same origin of medicine and food, has high safety, no obvious toxic and side effects, is suitable for long-term use, and has a wide range of promotion and application value.

[0083] The preparation method of the Chinese medicine composition provided in the embodiment of the present application enables each medicinal material to be fully cleaned, screened, crushed and dried during the processing, ensuring the purity of the raw medicinal materials and the retention of the effective ingredients. The crushed medicinal materials are accurately mixed in proportion to ensure the consistency of each batch of medicine, maximize the therapeutic effect of the composition, and ensure the safety of the preparation and the stability of quality.

[0084] The preparation method of the Chinese medicine composition provided in the embodiment of the present application also makes the medicinal material powder into granules with uniform particle size and moderate water content, which is convenient for patients to use and improves the appearance and taste of the medicine. The formation of the granule dosage form not only improves the convenience of taking the medicine, but also makes the medicine easier to dissolve and absorb in the gastrointestinal tract, thereby improving the efficacy.

[0085] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents the selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

Claims

1. A Chinese medicine composition for treating pleural effusion, characterized in that: The invention comprises the following raw materials in parts by weight: 15-25 parts of Codonopsis pilosula, 10-20 parts of raw Atractylodes macrocephala, 10-20 parts of Poria cocos, 4-8 parts of roasted Licorice root, 8-12 parts of Alisma orientalis, 10-14 parts of stir-fried Lepidium sativum seeds, 8-12 parts of jujubes, 8-12 parts of stir-fried Sinapis alba seeds, 4-8 parts of dried tangerine peel, 25-35 parts of roasted Astragalus membranaceus, 15-25 parts of Bupleurum chinense, 8-12 parts of Pinellia ternata, 8-12 parts of ginger, 8-12 parts of Scutellaria baicalensis, and 15-21 parts of raw Coix seeds.

2. The Chinese medicine composition for treating pleural effusion according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15-20 parts of Codonopsis pilosula, 10-15 parts of raw Atractylodes macrocephala, 10-15 parts of Poria cocos, 4-6 parts of roasted Licorice root, 8-10 parts of Alisma orientalis, 10-12 parts of stir-fried Lepidium sativum seeds, 8-10 parts of jujubes, 8-10 parts of stir-fried White mustard seeds, 4-10 parts of dried tangerine peel, 25-30 parts of roasted Astragalus membranaceus, 15-20 parts of Bupleurum chinense, 8-10 parts of Pinellia ternata, 8-10 parts of ginger, 8-10 parts of Scutellaria baicalensis, and 15-18 parts of raw Coix seeds.

3. The Chinese medicine composition for treating pleural effusion according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 20-25 parts of Codonopsis pilosula, 15-20 parts of raw Atractylodes macrocephala, 15-20 parts of Poria cocos, 6-8 parts of roasted Licorice root, 10-12 parts of Alisma orientalis, 12-14 parts of stir-fried Lepidium sativum seeds, 10-12 parts of jujubes, 10-12 parts of stir-fried Sinapis alba seeds, 6-8 parts of dried tangerine peel, 30-35 parts of roasted Astragalus membranaceus, 20-25 parts of Bupleurum chinense, 10-12 parts of Pinellia ternata, 10-12 parts of ginger, 10-12 parts of Scutellaria baicalensis, and 18-21 parts of raw Coix seeds.

4. The Chinese medicine composition for treating pleural effusion according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 15 parts of raw Atractylodes macrocephala, 15 parts of Poria cocos, 6 parts of roasted Licorice root, 10 parts of Alisma orientalis, 12 parts of stir-fried Lepidium officinale seeds, 10 parts of jujubes, 10 parts of stir-fried Sinapis alba seeds, 6 parts of dried tangerine peel, 30 parts of roasted Astragalus membranaceus, 20 parts of Bupleurum chinense, 10 parts of Pinellia ternata, 10 parts of ginger, 10 parts of Scutellaria baicalensis, and 18 parts of raw Coix seeds.

5. A method for preparing a Chinese medicine composition for treating pleural effusion, characterized in that: For preparing a Chinese medicine composition for treating pleural effusion according to any one of claims 1 to 4, the preparation method comprises the following steps: Step 1: Place raw materials such as Codonopsis pilosula, raw Atractylodes macrocephala, Poria cocos, roasted Licorice root, Alisma orientalis, stir-fried Lepidium tiliaceum seeds, jujube, stir-fried white mustard seeds, dried orange peel, stir-fried Astragalus membranaceus, Bupleurum chinense, Pinellia tuber, ginger, Scutellaria baicalensis, and raw Coix seeds on the screening table to remove impurities, insect-eaten parts, and other non-medicinal parts from the medicinal materials; Step 2: Rinse the selected medicinal materials in running water to remove dust, sand and other dirt on the surface; Step 3: Crush the medicinal materials according to their properties; Step 4: Spread the crushed herbs flat on a drying rack and place them in a cool and ventilated environment to dry naturally or dry the crushed herbs at low temperature; Step 5: Put the dried or baked medicinal materials into a grinder for crushing; Step 6: Weigh and proportion the crushed medicinal materials according to any one of claims 1-3, add them into a mixer, and mix for 10-20 minutes.

6. The preparation method according to claim 5, characterized in that: In the step 3, the codonopsis pilosula, atractylodes macrocephala, astragalus membranaceus and bupleurum are cut into 3-5 mm thin slices, the ginger is cut into 1-2 mm thin slices, the poria is cut into 5-10 mm thick slices, the jujube is pitted and cut into 2-3 mm thin slices, and the oriental water chestnut is cut into 2-4 mm thin slices; the pinellia and liquorice are processed and cut into 3 mm thin slices; the fried scutellaria baicalensis seeds and fried white mustard seeds are crushed with a pestle and mortar; the tangerine peel is broken into blocks with a side length of 3-5 mm; and the scutellaria baicalensis and coix seeds do not need to be processed.

7. The preparation method according to claim 6, characterized in that: In the step 4, the coix seeds and sliced ​​ginger are placed in a dryer and dried at a temperature between 40-60° C. until the moisture content drops below 10%, and the other crushed medicinal materials are spread on a drying rack and placed in a cool and ventilated environment to dry naturally.

8. The preparation method according to claim 5, characterized in that: The following steps are also included: Step 7: Put the evenly mixed medicinal powder into a mixer, gradually add the adhesive solution, and stir; Step 8: The moistened soft material is squeezed through a sieve or granulator with a pore size of 2-3 mm to form granules; Step 9: Spread the prepared wet granules evenly on a baking tray, put them into a dryer, and dry them at 50-60°C until the moisture content of the granules is less than 5%; Step 10: Screen the dried particles, retain the qualified particles, and re-crush and granulate the unqualified particles.

9. The preparation method according to claim 8, characterized in that: The binder is sodium carboxymethyl cellulose, the mass concentration of the binder is 2%-5%, and the mass ratio of the binder to the medicinal material powder is 10-15%.

10. The preparation method according to claim 8, characterized in that: In the step 10, the dried particles are sieved through a 1.2 mm or 1.5 mm sieve.