Full-automatic biochemical analyzer

Abstract

The full-automatic biochemical analyzer comprises a bottom plate and a back plate, a reaction disc mechanism and a reagent disc mechanism are arranged on the left side and the right side of the end face of the bottom plate respectively, and a reagent distribution mechanism and a sample distribution mechanism are symmetrically arranged between the reaction disc mechanism and the reagent disc mechanism; an automatic reaction disc cleaning mechanism and a stirring and uniform mixing mechanism are arranged on one side of the reaction disc mechanism, and a sample feeding mechanism is arranged at the other ends, away from the back plate, of the reaction disc mechanism and the reagent disc mechanism. The device has the beneficial effects that the device is high in speed, movement mechanisms are reduced, the movement mechanisms only comprise a sample distribution mechanism, a reagent distribution mechanism, a stirring mechanism, a reaction cup cleaning mechanism, a reaction disc and a reagent disc and sample sharing disc, the device supports track sample injection, online use with instruments of the same type is achieved, and the device is simple in structure and convenient to operate. The instrument supports a transmission detection system and a scattering detection system, and the transmission detection system and the scattering detection system are matched for use, so that a wider application range can be met, and the low-concentration sample detection sensitivity and the high-concentration sample detection range of turbidimetric items are effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of biochemical analyzers, in particular to a full-automatic biochemical analyzer. Background Art

[0002] The existing 400T / H fully automatic biochemical analyzer is generally a floor-standing structure, which includes two reagent sampling mechanisms, one sample sampling mechanism, two stirring mechanisms, a reaction cup cleaning mechanism, a reaction tray, a reagent tray and a sample tray mechanism.

[0003] The existing 400T / H fully automatic biochemical analyzer is large in size and has high requirements for the installation site. It has a complicated structure, high cost and high failure rate. It only supports sample tray injection, and the injection method is not flexible. It only supports transmitted light signal testing and has a limited scope of application. Summary of the invention

[0004] The object of the present invention is to provide a fully automatic biochemical analyzer to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned object, the present invention provides the following technical solutions: a fully automatic biochemical analyzer, comprising a bottom plate and a back plate, a reaction disk mechanism and a reagent disk mechanism are respectively arranged on the left and right sides of the end surface of the bottom plate, a reagent dispensing mechanism and a sample dispensing mechanism are symmetrically arranged between the reaction disk mechanism and the reagent disk mechanism, an automatic reaction disk cleaning mechanism and a stirring and mixing mechanism are arranged on one side of the reaction disk mechanism, and a sample injection mechanism is arranged on the other end of the reaction disk mechanism and the reagent disk mechanism away from the back plate;

[0006] The reaction disk mechanism comprises a reaction disk body, at least three support columns fixedly arranged with the bottom plate are symmetrically arranged at the lower end of the reaction disk body, a first rotating shaft connected with the reaction disk body is arranged between the three support columns, the first rotating shaft is drivingly connected with a first driving motor arranged at one side thereof, and an overflow interface is also arranged at one side of the reaction disk body;

[0007] The reagent disk mechanism comprises a reagent disk, at least two refrigeration components fixedly connected to the reagent disk are symmetrically arranged at the lower end of the reagent disk, a second rotating shaft connected to the reagent disk is arranged between the two refrigeration components, and the second rotating shaft is drivingly connected to a second driving motor arranged at one side of the second rotating shaft;

[0008] The reagent dispensing mechanism and the sample dispensing mechanism both include a second support frame fixedly arranged with the bottom plate, a third driving motor is arranged at the bottom of the second support frame, a first driving wheel connected with the third driving motor is arranged at the driving end of the third driving motor, the first driving wheel is connected with the driven wheel arranged at the upper end of the second support frame through a first driving belt, a fourth driving motor is arranged at the top of the second support frame, a second driving wheel is arranged at the driving end of the fourth driving motor, a rotating shaft rotatably connected with the third driving wheel is arranged at the other end of the second driving wheel away from the fourth driving motor, and a dispensing mechanism is arranged at the top of the rotating shaft;

[0009] A sample sampling needle is provided on the top of the sample dispensing mechanism;

[0010] The automatic cleaning mechanism of the reaction disk comprises a third support frame, a spring is arranged inside the third support frame, a connecting rod is arranged at the upper end of the spring, a mounting plate is arranged at the other end of the connecting rod away from the spring, and a plurality of cleaning heads are arranged at one end of the mounting plate.

[0011] For further optimization, a pulley is provided on the first rotating shaft, and the pulley is connected to a driving gear provided at a driving end of the first driving motor through a belt transmission.

[0012] Further optimized, multiple groups of reagent tubes are placed in the reagent tray, and among the three first support frames arranged at the bottom, two of the first support frames have columns for supporting the reagent tray at their upper ends, and a second drive motor is arranged at the upper end of another first support frame arranged between the two first support frames.

[0013] Further optimized, a linear slide rail is provided on one side of the second support frame, a slider slidably connected thereto is provided on the linear slide rail, and one end of the slider is fixedly connected to the first transmission belt.

[0014] Further optimized, the rotating shaft is fixedly arranged in the middle of the sliding block, a rotating shaft is installed on the rotating shaft, and the rotating shaft is drivingly connected to the fourth driving motor through a second transmission belt.

[0015] For further optimization, one side of the screw rod is provided with a fifth drive motor connected thereto.

[0016] In a further optimization, the dispensing mechanism comprises a connecting plate, an end surface of the connecting plate is provided with a circuit board, and the other end of the circuit board away from the rotating shaft is provided with a reagent dispensing needle.

[0017] Further optimized, the sample introduction mechanism includes a sample cache rack, a plurality of reagent racks are placed on the upper end of the reagent cache rack, at least two conveying motors are symmetrically provided on one side of the reagent cache rack, and a plurality of reagent tubes are placed in the plurality of reagent racks.

[0018] Further optimized, the stirring and mixing mechanism has the same lower structure as the reagent dispensing mechanism and the sample dispensing mechanism, and a fixing plate is provided on the top thereof, and a stirring rod is provided at one end of the fixing plate.

[0019] Beneficial Effects

[0020] The fully automatic biochemical analyzer provided by the present invention has a high instrument speed: it can reach 400T / H. By improving the running speed of each component, the purpose of reducing the motion mechanism is achieved. In terms of the motion mechanism, the instrument only includes a sample dispensing mechanism, a reagent dispensing mechanism, a stirring mechanism, a reaction cup cleaning mechanism, a reaction disk, and a reagent disk sample sharing disk. At the same time, the instrument supports track injection and can be used online with the same type of instruments. In terms of the detection system, the instrument supports two detection systems, transmission and scattering. The combination of the two can meet a wider range of applications and effectively improve the sensitivity of turbidimetric detection of low-concentration samples and the detection range of high-concentration samples. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0022] Figure 2 It is a schematic diagram of the reaction disk mechanism structure of the present invention;

[0023] Figure 3 It is a schematic diagram of the reagent disk mechanism structure of the present invention;

[0024] Figure 4 It is a bottom view schematic diagram of the reagent disk mechanism of the present invention;

[0025] Figure 5 It is a schematic diagram of the structure of the reagent dispensing mechanism and the sample dispensing mechanism of the present invention;

[0026] Figure 6 It is a schematic diagram of the structure of the stirring and mixing mechanism of the present invention;

[0027] Figure 7 It is a schematic diagram of the structure of the automatic cleaning mechanism of the reaction cup of the present invention. DETAILED DESCRIPTION

[0028] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0029] Example

[0030] like Figure 1-7As shown, a fully automatic biochemical analyzer is characterized in that: it includes a bottom plate 1 and a back plate 2, a reaction disk mechanism 6 and a reagent disk mechanism 3 are respectively arranged on the left and right sides of the end surface of the bottom plate 1, a reagent dispensing mechanism 4 and a sample dispensing mechanism 8 are symmetrically arranged between the reaction disk mechanism 6 and the reagent disk mechanism 3, a reaction disk automatic cleaning mechanism 5 and a stirring and mixing mechanism 7 are arranged on one side of the reaction disk mechanism 6, and a sample injection mechanism 9 is arranged on the other end of the reaction disk mechanism 6 and the reagent disk mechanism 3 away from the back plate 2;

[0031] The reaction disk mechanism 6 includes a reaction disk body 10, at least three support columns 12 fixedly arranged with the bottom plate 1 are symmetrically arranged at the lower end of the reaction disk body 10, a first rotating shaft 13 connected with the reaction disk body 10 is arranged between the three support columns 12, the first rotating shaft 13 is drivingly connected with a first driving motor 15 arranged at one side thereof, and an overflow interface 11 is also arranged at one side of the reaction disk body 10;

[0032] The reagent disk mechanism 3 includes a reagent disk 16, at least two refrigeration components 18 fixedly connected to the reagent disk 16 are symmetrically arranged at the lower end thereof, a second rotating shaft 19 connected to the reagent disk 16 is arranged between the two refrigeration components 18, and the second rotating shaft 19 is drivingly connected to a second driving motor 36 arranged at one side thereof;

[0033] The reagent dispensing mechanism 4 and the sample dispensing mechanism 8 both include a second support frame 21 fixedly arranged with the bottom plate 1, a third driving motor 22 is arranged at the bottom of the second support frame 21, a first driving wheel 23 connected thereto is arranged at the driving end thereof, the first driving wheel 23 is connected to a driven wheel arranged at the upper end of the second support frame 21 through a first transmission belt 24, a fourth driving motor 25 is arranged at the top of the second support frame 21, a second driving wheel is arranged at the driving end thereof, a rotating shaft 30 rotatably connected thereto is arranged at the other end of the second driving wheel away from the fourth driving motor 25, and a dispensing mechanism is arranged at the top of the rotating shaft 30;

[0034] A sample sampling needle 35 is provided on the top of the sample dispensing mechanism 8;

[0035] The reaction disk automatic cleaning mechanism 5 includes a third support frame 37, a spring 39 is arranged inside the third support frame 37, a connecting rod 40 is arranged at the upper end of the spring 39, a mounting plate 41 is arranged at the other end of the connecting rod 40 away from the spring 39, and a plurality of cleaning heads 42 are arranged at one end of the mounting plate 41.

[0036] In this embodiment, a pulley is provided on the first rotating shaft 13, and the pulley is connected to the pulley arranged at the driving end of the first drive motor 15 through a belt transmission; a plurality of groups of reagent tubes 17 are placed in the reagent tray 16, and two refrigeration components 18 are arranged at the bottom thereof, wherein the upper ends of the two refrigeration components 18 are provided with a column for supporting the reagent tray 16, and a second drive motor 36 is arranged between the two refrigeration components 18; a linear slide rail 28 is provided on one side of the second support frame 21, and a slider 27 slidably connected thereto is provided on the linear slide rail 28, and one end of the slider 27 is fixedly connected to the first transmission belt 24; a rotating shaft 30 is fixedly arranged in the middle of the slider 27, and a rotating shaft 29 is installed on the rotating shaft 30, and the rotating shaft 29 is drive-connected to the fourth drive motor 25 through a second transmission belt.

[0037] A fifth driving motor 38 connected to the spring 39 is disposed on one side thereof.

[0038] The dispensing mechanism comprises a connecting plate 31 , an end surface of which is provided with a circuit board 32 , and the other end of the circuit board 32 away from the rotating shaft 30 is provided with a reagent dispensing needle 33 .

[0039] The sample introduction mechanism 9 comprises a reagent buffer rack, a plurality of reagent racks are placed on the upper end of the reagent buffer rack, at least two conveying motors are symmetrically arranged on one side of the reagent buffer rack, and a plurality of reagent tubes are placed in the plurality of reagent racks.

[0040] The stirring and mixing mechanism 7 has the same lower structure as the reagent dispensing mechanism 4 and the sample dispensing mechanism 8 , and a fixing plate 34 is provided on the top thereof, and a stirring rod 35 is provided at one end of the fixing plate 34 .

[0041] The sample introduction mechanism is an optional structure that can meet the needs of different users. The measurement system includes a transmission optical detection system and a scattering optical detection system that can meet the needs of different detection projects.

[0042] The sample feeding mechanism is used to place the sample rack, and transport the sample to be tested to the sampling position through the transport mechanism;

[0043] The reaction disk mechanism provides the temperature conditions required for the reaction during the test. The temperature control system is used to control the temperature during the reaction. The temperature of the reaction liquid is kept constant at 37±0.3℃, and cooperates with the measurement system to complete the signal collection during the reaction.

[0044] The reagent tray mechanism is used to store the reagents required for the test and keep the reagents in a low-temperature refrigerated state. The temperature in the reagent compartment can be maintained at 2-8°C through the refrigeration control system; the corresponding reagents in the reagent tray are transported to the corresponding reagent taking positions through the motion control system; the reagent tray is divided into inner and outer circles, with a total of 60 reagent positions. The outer circle is used to place reagents or samples that need to be tested.

[0045] The sample distribution mechanism moves the sample in the sample tube into the reaction disk through the sample adding system for reaction and detection. The sample sampling mechanism can choose to sample from the sample disk or from the outer ring of the reagent disk.

[0046] The reagent dispensing mechanism moves the reagents in the reagent bottles into the reaction disk through the reagent dispensing system for reaction and detection. The reagent dispensing mechanism can choose to take the reagents from the inner circle of the reagents or from the outer circle of the reagents.

[0047] The stirring and mixing mechanism is used to mix the samples and reagents added to the reaction disk to make the reaction more complete. The stirring and mixing mechanism has two working positions in the reaction disk, corresponding to sample mixing and reagent mixing respectively.

[0048] The reaction cup cleaning mechanism is used to extract the waste liquid in the reaction cup and inject cleaning liquid and water to clean the reaction cup multiple times. After cleaning, the reaction cup can be used again.

[0049] The fluid circuit and supporting hardware and software control systems are used to control each device, collect, convert and calculate signals, and ultimately obtain the required test results.

[0050] The instrument is fast, small, low-cost, can be placed on a desktop, and is easy to install. The instrument can choose to sample through the track or the plate, and the sampling method is flexible to meet the needs of different users. At the same time, it can be used online with the same type of products, with strong scalability. The instrument can support transmission and scattered optical detection, which can meet the needs of different detection projects. Compared with existing products, it has better sensitivity and higher linear range.

[0051] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the invention content within the protection scope of the present invention.

Claims

1. A fully automatic biochemical analyzer, characterized in that: The invention comprises a bottom plate (1) and a back plate (2), wherein a reaction disk mechanism (6) and a reagent disk mechanism (3) are respectively arranged on the left and right sides of the end surface of the bottom plate (1), a reagent dispensing mechanism (4) and a sample dispensing mechanism (8) are symmetrically arranged between the reaction disk mechanism (6) and the reagent disk mechanism (3), an automatic reaction disk cleaning mechanism (5) and a stirring and mixing mechanism (7) are arranged on one side of the reaction disk mechanism (6), and a sample injection mechanism (9) is arranged on the other end of the reaction disk mechanism (6) and the reagent disk mechanism (3) away from the back plate (2); The reaction disk mechanism (6) comprises a reaction disk body (10), at least three support columns (12) fixedly arranged on the bottom plate (1) are symmetrically arranged at the lower end of the reaction disk body (10), a first rotating shaft (13) connected to the reaction disk body (10) is arranged between the three support columns (12), the first rotating shaft (13) is drivingly connected to a first driving motor (15) arranged on one side thereof, and an overflow interface (11) is also arranged on one side of the reaction disk body (10); The reagent disk mechanism (3) comprises a reagent disk (16), at least two refrigeration components (18) fixedly connected to the reagent disk (16) are symmetrically arranged at the lower end of the reagent disk (16), a second rotating shaft (19) connected to the reagent disk (16) is arranged between the two refrigeration components (18), and the second rotating shaft (19) is drivingly connected to a second driving motor (36) arranged at one side of the second rotating shaft (19); The reagent dispensing mechanism (4) and the sample dispensing mechanism (8) both comprise a second support frame (21) fixedly arranged on the bottom plate (1); a third driving motor (22) is arranged at the bottom of the second support frame (21); a first driving wheel (23) connected to the third driving motor is arranged at the driving end of the third driving motor; the first driving wheel (23) is connected to a driven wheel arranged at the upper end of the second support frame (21) by a first driving belt (24); a fourth driving motor (25) is arranged at the top of the second support frame (21); a second driving wheel is arranged at the driving end of the third driving motor; a rotating shaft (30) rotatably connected to the third driving motor is arranged at the other end of the second driving wheel away from the fourth driving motor (25); and a dispensing mechanism is arranged at the top of the rotating shaft (30); A sample sampling needle (35) is provided on the top of the sample dispensing mechanism (8); The reaction disk automatic cleaning mechanism (5) comprises a third support frame (37), a spring (39) is provided inside the third support frame (37), a connecting rod (40) is provided at the upper end of the spring (39), a mounting plate (41) is provided at the other end of the connecting rod (40) away from the spring (39), and a plurality of cleaning heads (42) are provided at one end of the mounting plate (41).

2. The fully automatic biochemical analyzer according to claim 1, characterized in that: A pulley is provided on the first rotating shaft (13), and the pulley is connected to a driving gear provided at the driving end of the first driving motor (15) through a belt transmission.

3. The fully automatic biochemical analyzer according to claim 1, characterized in that: A plurality of groups of reagent tubes (17) are placed in the reagent tray (16), and three first support frames (18) are arranged at the bottom thereof, wherein two of the first support frames (18) are provided with columns for supporting the reagent tray (16) at their upper ends, and a second drive motor (36) is provided at the upper end of another first support frame (18) arranged between the two first support frames (18).

4. The fully automatic biochemical analyzer according to claim 1, characterized in that: A linear slide rail (28) is provided on one side of the second support frame (21), a slider (27) slidably connected thereto is provided on the linear slide rail (28), and one end of the slider (27) is fixedly connected to the first transmission belt (24).

5. The fully automatic biochemical analyzer according to claim 4, characterized in that: The rotating shaft (30) is fixedly arranged in the middle of the sliding block (27), and a rotating shaft (29) is installed on the rotating shaft (30). The rotating shaft (29) is drivingly connected to the fourth driving motor (25) through a second transmission belt.

6. The fully automatic biochemical analyzer according to claim 1, characterized in that: A fifth drive motor (38) connected to the lead screw (39) is provided on one side thereof.

7. The fully automatic biochemical analyzer according to claim 1, characterized in that: The dispensing mechanism comprises a connecting plate (31), the end surface of which is provided with a circuit board (32), and the other end of the circuit board (32) away from the rotating shaft (30) is provided with a reagent dispensing needle (33).

8. The fully automatic biochemical analyzer according to claim 1, characterized in that: The sample introduction mechanism (9) comprises a sample buffer rack, a plurality of reagent racks are placed on the upper end of the reagent buffer rack, at least two conveying motors are symmetrically arranged on one side of the reagent buffer rack, and a plurality of reagent tubes are placed in the plurality of reagent racks.

9. The fully automatic biochemical analyzer according to claim 1, characterized in that: The stirring and mixing mechanism (7) has the same lower structure as the reagent dispensing mechanism (4) and the sample dispensing mechanism (8), and a fixing plate (34) is provided on the top thereof, and a stirring rod (35) is provided at one end of the fixing plate (34).

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