Manganese substitute-containing water dispersible granule, preparation method and application

Abstract

The invention discloses a manganese substitute-containing water dispersible granule as well as a preparation method and application thereof. The water dispersible granule containing the manganese substitute is prepared from 70 to 90 parts of mancozeb microcapsules and 10 to 20 parts of auxiliaries, the microcapsule comprises a capsule wall and a capsule core; the capsule wall comprises a glucan solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of (1-3): (3-5): (1-2): (5-7); the capsule core comprises diatomite loaded with mancozeb. According to the water dispersible granule, through a specific proportion and a preparation process, good coating and stable release of effective components are realized, the utilization rate and the lasting period of pesticides are improved, and environmental pollution is reduced, so that crop diseases and insect pests are effectively controlled.

Description

Technical Field

[0001] The present application relates to the technical field of pesticides, and in particular to a water-dispersible granule containing a manganese substitute, a preparation method and an application thereof. Background Art

[0002] With the development of agricultural production, the problem of crop diseases and insect pests has become increasingly prominent. In order to effectively control diseases and insect pests, farmers often need to use a large amount of pesticides. However, traditional pesticide preparations containing substitute manganese have problems such as low utilization rate, easy dispersion, and environmental pollution. In order to improve the utilization rate of pesticides containing substitute manganese and reduce environmental pollution, people have begun to study new pesticide preparations. Among them, water-dispersible granules containing substitute manganese, as a new type of pesticide formulation, have the advantages of good dispersibility, high stability, and easy use, and have gradually become a research hotspot in the field of pesticide preparations. At present, although there have been some research reports on water-dispersible granules, there are still problems such as unsatisfactory coating effect and unstable release. Therefore, how to develop a water-dispersible granule with good coating effect and stable release is a problem to be solved in the current field of pesticide preparations. Summary of the invention

[0003] In order to solve at least one of the above technical problems, a pesticide containing a manganese substitute with better stability, longer lasting effect, environmental friendliness and better dispersibility is developed. The present application provides a water-dispersible granule containing a manganese substitute, a preparation method and application. In a first aspect, the present application provides a water-dispersible granule containing a manganese substitute, the water-dispersible granule containing a manganese substitute comprises 70-90 parts of mancozeb microcapsules and 10-20 parts of an adjuvant; The microcapsule comprises a capsule wall and a capsule core; The capsule wall comprises a dextran solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of (1-3): (3-5): (1-2): (5-7); The capsule core comprises diatomaceous earth loaded with mancozeb.

[0004] By adopting the above technical scheme, the present application provides an innovative water-dispersible granule containing manganese substitute to cope with the shortcomings of current pesticide formulations, aiming to create an efficient, long-lasting, environmentally friendly and well-dispersible pesticide product to meet the high standards of modern agricultural production. The present application adopts microcapsule technology to accurately encapsulate the effective ingredient of mancozeb, supplemented by specific adjuvants, which together constitute the main body of the preparation. This structural design significantly improves the stability and lasting effect of the pesticide, while reducing the potential impact on the environment. The capsule wall is the core component of the microcapsule, which is synergistically constructed by benzalkonium chloride, ethanol, zein and pectin glucan solution. Benzalkonium chloride, as a cationic surfactant, is tightly bound to negatively charged pectin molecules through electrostatic interactions to form a firm capsule wall matrix. Zein further enhances the mechanical strength and biological stability of the capsule wall due to its good film-forming properties and biocompatibility. The addition of pectin and glucan solution not only strengthens the structural integrity of the capsule wall, but also gives it a certain selective permeability, which helps to control the release rate of mancozeb in the capsule core, ensures that the pesticide is released on demand in the target environment, and improves the use efficiency of the pesticide. The capsule core part includes diatomaceous earth loaded with mancozeb. As a natural porous material, diatomaceous earth has a huge specific surface area, can efficiently adsorb and carry mancozeb, and ensures a high load of the pesticide component. At the same time, the porous structure of diatomaceous earth provides a slow-release environment for mancozeb, which helps to extend the lasting effect of pesticides, reduce the need for frequent application of pesticides, and thus reduce the pressure on the environment. Auxiliary agents play a vital role in the water-dispersible granules of this application. They not only promote the uniform dispersion of microcapsules, but also optimize the physicochemical properties of the preparation, such as improving water solubility, improving fluidity, enhancing anti-caking ability, etc., thereby ensuring that in practical applications, pesticides can be quickly dispersed in water to form a uniform and stable suspension, which is convenient for spraying operations and improves the convenience and effect of pesticide use.

[0005] In summary, the water-dispersible granules containing mancozeb provided in the present application achieve effective encapsulation, controlled release and efficient utilization of mancozeb through sophisticated capsule wall and capsule core design, as well as the synergistic effect of adjuvants, providing a greener and smarter pesticide solution for the agricultural field, which is expected to reduce the impact on the ecological environment while ensuring the healthy growth of crops.

[0006] Optionally, the weight ratio of the capsule wall material to the capsule core material is (3-5):1.

[0007] By adopting the above technical solution, the weight ratio of the capsule wall raw material and the capsule core raw material is set in the range of (3-5): 1, and the water-dispersible granules containing manganese substitutes of the present application show excellent technical effects. This carefully designed ratio ensures the optimal balance of the microcapsule structure, and the capsule wall raw material fully surrounds and protects the capsule core, forming a solid barrier, effectively isolating the influence of the external environment on the mancozeb in the capsule core, and significantly improving the stability of the pesticide. At the same time, this ratio also optimizes the thickness and elasticity of the capsule wall, so that the microcapsule has good mechanical strength and selective permeability, which can not only ensure the integrity of the pesticide components during storage and transportation, but also control its release rate in the target environment, and realize the precise application and long-term effect of the pesticide. In addition, this ratio is also conducive to improving the overall dispersibility of the water-dispersible granules, ensuring that a uniform and stable suspension can be quickly formed in practical applications, thereby improving the use efficiency and operation convenience of the pesticide. In summary, this innovative formula ratio not only greatly improves the performance of the pesticide, but also reflects the friendliness to the environment and the contribution to the sustainable development of agriculture, and provides an efficient and intelligent pesticide solution for modern agricultural production.

[0008] Optionally, the diatomaceous earth loaded with mancozeb is prepared from diatomaceous earth, acid solution and mancozeb in a weight ratio of 80:5:(5-10).

[0009] By adopting the above technical scheme, the diatomaceous earth loaded with mancozeb is prepared from diatomaceous earth, acid solution and mancozeb in a weight ratio of 80:5:(5-10), and the water-dispersible granules containing mancozeb in the present application show a series of significant technical effects. This carefully designed weight ratio ensures that mancozeb can be efficiently adsorbed and carried by diatomaceous earth. As a natural porous material, diatomaceous earth has a large specific surface area and rich pore structure to provide an ideal loading platform for mancozeb, thereby greatly improving the loading capacity and sustained release performance of the pesticide. The addition of acid solution not only optimizes the surface properties of diatomaceous earth and enhances its adsorption capacity for mancozeb, but also promotes the uniform distribution of mancozeb on diatomaceous earth, ensuring the stability of the pesticide components. The use of this ratio also effectively controls the release rate of the pesticide, so that mancozeb can be slowly released in the target environment according to demand, prolongs the effective period of the pesticide, reduces the number of repeated application, and thus reduces the pressure on the environment. In addition, this technical solution has significantly improved the efficiency of pesticide use, reduced the total amount of pesticides used, reduced costs, and greatly reduced the impact on non-target organisms, reflecting the green and intelligent trend of pesticide formulations, providing a powerful disease prevention and control method for modern agricultural production, and promoting the sustainable development of agriculture. In summary, this innovative loading technology not only improves the performance of pesticides, but also reflects the care for the environment and the maintenance of agricultural ecological balance. It is an important breakthrough in the field of pesticide formulation.

[0010] Optionally, the acid solution is selected from dilute sulfuric acid solution.

[0011] Optionally, the method for preparing the mancozeb microcapsules comprises the following steps: A1. Prepare a glucan solution containing pectin and set aside; A2, diatomaceous earth and an acid solution are mixed to obtain an acid solution of diatomaceous earth, and mancozeb is added, mixed and stirred, and dried to obtain the diatomaceous earth loaded with mancozeb; A3, dissolving benzalkonium chloride and zein in ethanol to form a mixed solution A, and adding the diatomaceous earth loaded with mancozeb obtained in step A2, mixing and stirring to obtain a mixed solution B, A4, and dripping the pectin-containing glucan solution dropwise into the mixed solution B, and adjusting the pH to 5.0-6.0, and performing a mixed stirring reaction. After the reaction is completed, removing the solvent, adjusting the pH to neutral, and drying to obtain the mancozeb microcapsules.

[0012] By adopting the preparation method of the above-mentioned mancozeb microcapsules, the water dispersible granules containing manganese substitute of the present application have shown a series of outstanding technical effects. First, the configuration of the glucan solution containing pectin in step A1 has laid a foundation for the formation of the subsequent capsule wall. The combination of pectin and glucan not only increases the stability and mechanical strength of the capsule wall, but also gives the capsule wall good biocompatibility and selective permeability, which plays a key role in the protection and controlled release of the pesticide component. Then, in step A2, the mixed treatment of diatomaceous earth and acid solution optimizes the surface characteristics of diatomaceous earth, enhances its adsorption capacity to mancozeb, and ensures the efficient loading of the pesticide component. The combination of mancozeb and diatomaceous earth makes full use of the large specific surface area and porous structure of diatomaceous earth, not only improves the loading capacity of pesticide, but also realizes the slow release of pesticide, and prolongs the lasting period. Subsequently, in step A3, benzalkonium chloride and zein are dissolved in ethanol and mixed with diatomaceous earth loaded with mancozeb to form a mixed solution B. Benzalkonium chloride, as a cationic surfactant, forms an electrostatic interaction with the negative charge of pectin, strengthens the structure of the capsule wall, and the addition of zein further enhances the biological stability of the capsule wall, ensuring the integrity of the microcapsule and the safety of the pesticide components. Finally, in step A4, the pectin-containing glucan solution reacts with the mixed solution B, and the formation of the capsule wall is promoted by adjusting the pH value to 5.0-6.0. This pH range is conducive to the interaction of the capsule wall materials, ensuring the uniform formation and stability of the capsule wall. After the reaction is completed, the solvent is removed, the pH is adjusted to neutral and dried, and the obtained mancozeb microcapsules have excellent physical and chemical stability, can maintain the activity of the pesticide components during storage and transportation, and release them on demand in the target environment, thereby improving the use efficiency and environmental adaptability of the pesticide.

[0013] In summary, the microcapsule preparation method of the present application not only achieves effective encapsulation and controlled release of mancozeb by precisely controlling the proportion of each component and the reaction conditions, but also significantly improves the stability, duration and dispersibility of the pesticide, providing an efficient, intelligent and environmentally friendly pesticide solution for the agricultural field, which is of great significance for promoting modern agricultural production to develop in a more sustainable direction.

[0014] Optionally, the pectin-glucan solution is prepared by mixing pectin and glucan with water in a weight ratio of (1-3):(25-30):(60-80).

[0015] Optionally, the auxiliary agent includes at least one of a dispersant, a wetting agent and a thickener.

[0016] By adopting the above technical scheme and the rational selection of adjuvants, the physical and chemical properties of the water-dispersible granules containing manganese substitutes are not only optimized, such as improving their dispersibility, wettability and stability, but also significantly enhancing the biological efficacy and environmental adaptability of the pesticide. This allows the water-dispersible granules of the present application to minimize the negative impact on the ecological environment while ensuring efficient disease prevention and control, embodying the research and development concept of green pesticide preparations, and is of great significance to promoting the sustainable development of agriculture.

[0017] Optionally, the dispersant is selected from calcium lignin sulfonate; The wetting agent is selected from polysorbates; The thickener is selected from xanthan gum.

[0018] In a second aspect, the present application provides a method for preparing the water-dispersible granules containing a manganese substitute, the preparation method comprising the following steps: mixing mancozeb microcapsules and an auxiliary agent to prepare the water-dispersible granules containing a manganese substitute.

[0019] By adopting the above technical scheme, the preparation method of the present application not only simplifies the production process and improves production efficiency, but also ensures the high quality and high performance of water-dispersible granules, provides an efficient, environmentally friendly and intelligent pesticide solution for the agricultural field, promotes the advancement of pesticide formulation technology, and promotes the sustainable development of agriculture.

[0020] In a third aspect, the present application provides an application of a water-dispersible granule containing a manganese substitute in the field of pesticides.

[0021] By adopting the above-mentioned technical scheme, the application of the water-dispersible granules containing manganese substitutes in the pesticide field of the present application not only improves the performance and efficiency of pesticide formulations, but also reflects respect and protection for the environment, and provides strong technical support for realizing the green transformation and sustainable development of agriculture. It is an important achievement of modern agricultural science and technology innovation.

[0022] In summary, the present invention includes at least one of the following beneficial technical effects: 1. In order to address the shortcomings of current pesticide formulations, this application provides an innovative water-dispersible granule containing manganese substitute, aiming to create an efficient, long-lasting, environmentally friendly and well-dispersible pesticide product to meet the high standards of modern agricultural production. This application uses microencapsulation technology to accurately encapsulate the active ingredient of mancozeb, supplemented by specific adjuvants, which together constitute the main body of the preparation. This structural design significantly improves the stability and lasting effect of the pesticide, while reducing the potential impact on the environment. The capsule wall is the core component of the microcapsule, which is synergistically constructed by benzalkonium chloride, ethanol, zein and pectin glucan solution. Benzalkonium chloride, as a cationic surfactant, is tightly bound to negatively charged pectin molecules through electrostatic interactions to form a strong capsule wall matrix. Zein further enhances the mechanical strength and biological stability of the capsule wall due to its good film-forming properties and biocompatibility. The addition of pectin and glucan solution not only strengthens the structural integrity of the capsule wall, but also gives it a certain selective permeability, which helps to control the release rate of mancozeb in the capsule core, ensures that the pesticide is released on demand in the target environment, and improves the use efficiency of the pesticide. The capsule core part includes diatomaceous earth loaded with mancozeb. As a natural porous material, diatomaceous earth has a huge specific surface area, can efficiently adsorb and carry mancozeb, and ensures a high load of the pesticide component. At the same time, the porous structure of diatomaceous earth provides a slow-release environment for mancozeb, which helps to extend the lasting effect of pesticides, reduce the need for frequent application of pesticides, and thus reduce the pressure on the environment. Auxiliary agents play a vital role in the water-dispersible granules of this application. They not only promote the uniform dispersion of microcapsules, but also optimize the physicochemical properties of the preparation, such as improving water solubility, improving fluidity, enhancing anti-caking ability, etc., thereby ensuring that in practical applications, pesticides can be quickly dispersed in water to form a uniform and stable suspension, which is convenient for spraying operations and improves the convenience and effect of pesticide use.

[0023] In summary, the water-dispersible granules containing mancozeb provided in the present application achieve effective encapsulation, controlled release and efficient utilization of mancozeb through sophisticated capsule wall and capsule core design, as well as the synergistic effect of adjuvants, providing a greener and smarter pesticide solution for the agricultural field, which is expected to reduce the impact on the ecological environment while ensuring the healthy growth of crops.

[0024] 2. The diatomite loaded with mancozeb is prepared from diatomite, acid solution and mancozeb in a weight ratio of 80:5:(5-10). The water-dispersible granules containing mancozeb in the present application show a series of remarkable technical effects. This carefully designed weight ratio ensures that mancozeb can be efficiently adsorbed and carried by diatomite. As a natural porous material, diatomite has a large specific surface area and rich pore structure to provide an ideal loading platform for mancozeb, thereby greatly improving the loading capacity and sustained release performance of the pesticide. The addition of acid solution not only optimizes the surface properties of diatomite and enhances its adsorption capacity for mancozeb, but also promotes the uniform distribution of mancozeb on diatomite, ensuring the stability of the pesticide components. The use of this ratio also effectively controls the release rate of the pesticide, so that mancozeb can be slowly released in the target environment according to demand, prolongs the effective period of the pesticide, reduces the number of repeated application, and thus reduces the pressure on the environment. In addition, this technical solution has significantly improved the efficiency of pesticide use, reduced the total amount of pesticides used, reduced costs, and greatly reduced the impact on non-target organisms, reflecting the green and intelligent trend of pesticide formulations, providing a powerful disease prevention and control method for modern agricultural production, and promoting the sustainable development of agriculture. In summary, this innovative loading technology not only improves the performance of pesticides, but also reflects the care for the environment and the maintenance of agricultural ecological balance. It is an important breakthrough in the field of pesticide formulation. DETAILED DESCRIPTION

[0025] The present application is further described in detail below in conjunction with embodiments. Specific embodiments

[0026] Benzalkonium chloride: CAS No. 63449-41-2), purity 99%.

[0027] Ethanol: CAS No. 64-17-5, purity 95%.

[0028] Zein: CAS No. 9010-66-6, purity 98%.

[0029] Pectin: CAS No. 9000-69-5, purity 99%.

[0030] Dextran: Hanbang Huanyu, CAS No. 9004-54-0, purity 99%.

[0031] Mancozeb: CAS No. 8018-01-7, purity 99%.

[0032] Diatomaceous earth: CAS No. 61790-53-2, purity 99%.

[0033] Calcium lignin sulfonate: CAS No. 8061-52-7, purity 99%.

[0034] Polysorbate: CAS No. 9005-65-6, purity 99%.

[0035] Xanthan gum: CAS No. 11138-66-2, purity 99%.

[0036] Example 1 This embodiment provides a water dispersible granule containing manganese substitute, including 70 parts of mancozeb microcapsules and 10 parts of an auxiliary agent; The microcapsule comprises a capsule wall and a capsule core; the weight ratio of the capsule wall material to the capsule core material is 3:1.

[0037] The capsule wall includes a dextran solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of 1:3:1:5; The capsule core comprises diatomaceous earth loaded with mancozeb.

[0038] The mancozeb-loaded diatomaceous earth is prepared from diatomaceous earth, an acid solution (the acid solution is selected from a dilute sulfuric acid solution with a concentration of 10%) and mancozeb in a weight ratio of 80:5:5.

[0039] The preparation method of water dispersible granules containing manganese substitute comprises the following steps: A1. Prepare a pectin-containing glucan solution for later use; the pectin-containing glucan solution is prepared by mixing pectin, glucan and water in a weight ratio of 1:25:60.

[0040] A2, diatomaceous earth and acid solution are mixed to obtain an acid solution of diatomaceous earth, and mancozeb is added, mixed and stirred, and dried (drying temperature is 60° C., drying time is 2 hours), to obtain diatomaceous earth loaded with mancozeb; A3, dissolving benzalkonium chloride and zein in ethanol to form a mixed solution A, and adding the diatomaceous earth loaded with mancozeb obtained in step A2, mixing and stirring (stirring speed is 300 rpm, stirring time is 30 minutes), to obtain a mixed solution B, A4, and dripping the pectin-containing glucan solution dropwise into the mixed solution B, and adjusting the pH to 6.0, and performing a mixed stirring reaction. After the reaction is completed, removing the solvent, adjusting the pH to neutral (7.0), and drying (drying temperature is 50° C., and drying time is 4 hours) to obtain mancozeb microcapsules.

[0041] The dispersant in this embodiment is calcium lignin sulfonate; The wetting agent in this embodiment is polysorbate; The thickener in this embodiment is xanthan gum.

[0042] Among the additives in this embodiment, the weight ratio of the dispersant, the wetting agent and the thickener is 1:1:1.

[0043] Example 2 The difference between this embodiment and embodiment 1 is that in this embodiment, when preparing the water dispersible granules containing mancozeb, 85 parts of mancozeb microcapsules and 18 parts of auxiliary agents are included.

[0044] Example 3 The difference between this embodiment and embodiment 1 is that in this embodiment, when preparing the water dispersible granules containing mancozeb, 90 parts of mancozeb microcapsules and 20 parts of auxiliary agents are included.

[0045] Example 4 The difference between this embodiment and embodiment 2 is that, in this embodiment, when preparing the water dispersible granules containing manganese substitute, the capsule wall comprises a dextran solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of 2:4.5:1.5:6.4.

[0046] The mancozeb-loaded diatomaceous earth is prepared from diatomaceous earth, an acid solution (the acid solution is selected from a dilute sulfuric acid solution) and mancozeb in a weight ratio of 80:5:8.

[0047] Example 5 The difference between this embodiment and embodiment 2 is that, in this embodiment, when preparing the water dispersible granules containing manganese substitute, the capsule wall comprises a dextran solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of 3:5:2:7.

[0048] The mancozeb-loaded diatomaceous earth is prepared from diatomaceous earth, an acid solution (the acid solution is selected from a dilute sulfuric acid solution) and mancozeb in a weight ratio of 80:5:10.

[0049] Example 6 The difference between this embodiment and embodiment 4 is that in this embodiment, when preparing the water dispersible granules containing manganese substitute, the preparation method includes the following steps: A1. Prepare a glucan solution containing pectin and set aside; The pectin-dextran solution is prepared by mixing and stirring pectin, dextran and water in a weight ratio of 2.5:28:76.

[0050] A2, diatomaceous earth and an acid solution are mixed to obtain an acid solution of diatomaceous earth, and mancozeb is added, mixed and stirred, and dried to obtain the diatomaceous earth loaded with mancozeb; A3, dissolving benzalkonium chloride and zein in ethanol to form a mixed solution A, and adding the diatomaceous earth loaded with mancozeb obtained in step A2, mixing and stirring to obtain a mixed solution B, A4, and dripping the pectin-containing glucan solution dropwise into the mixed solution B, and adjusting the pH to 5.0, and performing mixed stirring reaction. After the reaction is completed, removing the solvent, adjusting the pH to a neutral pH of 7.0, and drying to obtain mancozeb microcapsules.

[0051] Example 7 The difference between this embodiment and embodiment 4 is that in this embodiment, when preparing the water dispersible granules containing manganese substitute, the preparation method includes the following steps: A1. Prepare a pectin-containing dextran solution for later use; the pectin-containing dextran solution is prepared by mixing pectin, dextran and water in a weight ratio of 3:30:80.

[0052] A2, diatomaceous earth and an acid solution are mixed to obtain an acid solution of diatomaceous earth, and mancozeb is added, mixed and stirred, and dried to obtain the diatomaceous earth loaded with mancozeb; A3, dissolving benzalkonium chloride and zein in ethanol to form a mixed solution A, and adding the diatomaceous earth loaded with mancozeb obtained in step A2, mixing and stirring to obtain a mixed solution B, A4, and dripping the pectin-containing glucan solution dropwise into the mixed solution B, and adjusting the pH to 5.0, and performing mixed stirring reaction. After the reaction is completed, removing the solvent, adjusting the pH to a neutral pH of 7.0, and drying to obtain mancozeb microcapsules.

[0053] Comparative Examples 1-3 Comparative Example 1 The difference between this comparative example and Example 1 is that when preparing the water dispersible granules containing manganese substitute, the capsule wall is not included in this comparative example.

[0054] Comparative Example 2 The difference between this comparative example and Example 1 is that, when preparing the water dispersible granules containing manganese substitute, the capsule wall in this comparative example comprises a dextran solution of ethanol, zein and pectin in a weight ratio of 3:1.5:6.5.

[0055] Comparative Example 3 The difference between this comparative example and Example 1 is that, when preparing the water dispersible granules containing manganese substitute, the capsule wall in this comparative example comprises a dextran solution of benzalkonium chloride, ethanol and pectin in a weight ratio of 1.5:3:6.5.

[0056] Experimental testing Testing of thermal storage stability: Tested in accordance with GB / T 19136-2003.

[0057] The mixture was placed for 3 months and the content of active ingredients was tested; stable (qualified) means the content is higher than 90%; unstable (unqualified) means the content is less than 80%.

[0058] Suspension rate determination: Determined in accordance with GB / T 14825-2006.

[0059] Control effect: The preparation prepared in the above example was used to control potato late blight.

[0060] Experimental treatment: The dosage of the test pesticides was set at three treatment concentrations according to the different components. The control pesticides were 80% mancozeb wettable powder of the commercial pesticide and a blank control of clean water.

[0061] Test method: The test was conducted in fields where potato late blight was more serious in previous years. Each plot was 30m 2 , repeated 4 times. The investigation method and efficacy evaluation were carried out according to GB / T17980.34-2000.

[0062] The disease classification standards are as follows Level 0: no lesions; Level 1: The lesion area accounts for less than 5% of the entire leaf area; Level 3: The lesion area accounts for 6% to 10% of the entire leaf area; Level 5: The lesion area accounts for 11% to 20% of the entire leaf area; Level 7: The lesion area accounts for 21% to 50% of the entire leaf area; Level 9: The lesion area accounts for more than 50% of the total leaf area.

[0063] Calculation method of drug efficacy: Based on the survey results, the disease index and prevention efficacy were calculated using the following formulas (1) and (2).

[0064] Disease index = ∑ [number of leaves at each level * relative level value] / (total number of surveys * 9) * 100.

[0065] Control effect (%) = [1-[(CK0*PT1) / (CK1*PT0)]]*100.

[0066] Where: CK0 and CK1 are the disease indexes of the blank control area before and after application; PT0 and PT1 are the disease indexes of the drug-treated area before and after application. Spray 200 mg / kg twice, and test the control effect at 10, 20, and 30 days after application.

[0067] The experimental test results of Examples 1-7 and Comparative Examples 1-3 are shown in Table 1.

[0068] Table 1 - Experimental test results of Examples 1-7 and Comparative Examples 1-3 Results Analysis The difference between Examples 2-7 and Example 1 is that different preparation parameters are used in the preparation of the water-dispersible granules containing manganese substitutes. Combined with the experimental test data in Table 1, it can be seen that the water-dispersible granules containing manganese substitutes prepared by Examples 1-7 all have better heat storage stability, suspension rate and lasting effect.

[0069] However, the difference between Comparative Example 1 and Example 1 is that when preparing the water-dispersible granules containing substitute manganese, the capsule wall is not included in this comparative example. It can be seen from the experimental test data in Table 1 that if the active ingredient is not wrapped when preparing the water-dispersible granules containing substitute manganese, the storage stability and the lasting period of the active ingredient will be poor. The reason may be that when preparing the water-dispersible granules containing substitute manganese, the lack of the capsule wall directly exposes the active ingredient to the external environment, which will lead to the following problems; without the protection of the capsule wall, the active ingredient will directly contact the oxygen and moisture in the air, accelerate the occurrence of oxidation and hydrolysis reactions, thereby causing the degradation and failure of the active ingredient. The active ingredient is more sensitive to temperature changes, and high temperature conditions may cause the volatilization, decomposition or denaturation of the active ingredient, affecting its stability and efficacy. During storage, the active ingredient may affect the uniformity and dispersibility of the preparation due to changes in physical state (such as crystallization, aggregation), reducing the suspension rate and the effect of use. Due to the above factors, the activity and concentration of the active ingredient decrease rapidly over time, resulting in a significant shortening of the duration of the preparation, which may have lost its effectiveness before the expected use. In summary, the capsule wall plays a key barrier role in water-dispersible granules. It not only isolates the active ingredient from the external environment and delays the degradation of the active ingredient, but also controls the release rate of the active ingredient to ensure that sufficient efficacy is provided within an appropriate time. Therefore, it is very important to use appropriate capsule wall materials and processes when preparing water-dispersible granules containing manganese substitutes to ensure the storage stability and long-term effect of the preparation.

[0070] The difference between Comparative Example 2 and Example 1 is that when preparing the water dispersible granules containing substitute manganese, the capsule wall in this comparative example includes a dextran solution of ethanol, zein and pectin in a weight ratio of 3:1.5:6.5. It is not difficult to see that the capsule wall material in Comparative Example 2 does not include benzalkonium chloride. Combined with the experimental data in Table 1, it can be seen that the absence of benzalkonium chloride will lead to poor storage stability and efficacy of the water dispersible granules containing substitute manganese. The reason may be that benzalkonium chloride has a positive charge and can form a stable complex with other negatively charged components in the capsule wall through electrostatic attraction. This bonding helps to enhance the structural stability of the capsule wall and improve the protective effect on the capsule core material.

[0071] The difference between Comparative Example 3 and Example 1 is that when preparing the water dispersible granules containing manganese substitute, the capsule wall in this comparative example includes benzalkonium chloride, ethanol and pectin glucan solution with a weight ratio of 1.5:3:6.5. It is not difficult to see that when preparing the capsule wall material in Comparative Example 3, no zein was added. Combined with the experimental test data in Table 1, it can be seen that although the positive and negative electron bonding formed by the benzalkonium chloride and pectin glucan solution can protect the capsule core material to a certain extent, there are still problems of poor storage stability and suspension rate and poor sustained release effect. The reason may be that zein plays a key role in enhancing the mechanical strength and biological stability of the capsule wall in the capsule wall material. Its absence leads to the weakening of the physical properties of the capsule wall, which is not enough to effectively resist the influence of external environmental factors (such as humidity and temperature changes) on the active ingredients in the capsule core, thereby reducing the storage stability and suspension rate of the preparation. In addition, the lack of zein may also affect the density and continuity of the capsule wall, resulting in the premature release of the active ingredients in the capsule core, thereby affecting the sustained release effect and duration of the water-dispersible granules containing manganese substitutes.

[0072] It can be seen from the experimental data in Table 1 that the performance of the water dispersible granules containing manganese substitute in Comparative Example 3 is reduced, especially compared with Example 1, its heat storage stability, suspension rate and lasting period are all reduced. This shows that zein is not only an important component of the capsule wall structure, but also has an indispensable contribution to the performance of the entire water dispersible granules. Zein, benzalkonium chloride, and pectin glucan solution work synergistically to jointly construct an efficient and stable capsule wall system, ensuring the stability and efficacy of the active ingredient during storage and use.

[0073] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A water dispersible granule containing manganese substitute, characterized in that: The water dispersible granules containing manganese substitutes include 70-90 parts of mancozeb microcapsules and 10-20 parts of auxiliary agents; The microcapsule comprises a capsule wall and a capsule core; The capsule wall comprises a dextran solution of benzalkonium chloride, ethanol, zein and pectin in a weight ratio of (1-3): (3-5): (1-2): (5-7); The capsule core comprises diatomaceous earth loaded with mancozeb.

2. The water dispersible granules containing manganese substitute according to claim 1, characterized in that: The weight ratio of the capsule wall material to the capsule core material is (3-5):

1.

3. The water dispersible granules containing manganese substitute according to claim 1, characterized in that: The mancozeb-loaded diatomaceous earth is prepared from diatomaceous earth, acid solution and mancozeb in a weight ratio of 80:5:(5-10).

4. The water dispersible granules containing manganese substitute according to claim 3, characterized in that: The acid solution is selected from dilute sulfuric acid solution.

5. The water dispersible granules containing manganese substitute according to claim 1, characterized in that: The preparation method of the mancozeb microcapsule comprises the following steps: A1. Prepare a glucan solution containing pectin and set aside; A2, diatomaceous earth and an acid solution are mixed to obtain an acid solution of diatomaceous earth, and mancozeb is added, mixed and stirred, and dried to obtain the diatomaceous earth loaded with mancozeb; A3, dissolving benzalkonium chloride and zein in ethanol to form a mixed solution A, and adding the diatomaceous earth loaded with mancozeb obtained in step A2, mixing and stirring to obtain a mixed solution B, A4, dripping the pectin-containing glucan solution dropwise into the mixed solution B, adjusting the pH to 5.0-6.0, and performing a mixed stirring reaction. After the reaction is completed, removing the solvent, adjusting the pH to neutral, and drying to obtain the mancozeb microcapsules.

6. The water dispersible granules containing manganese substitute according to claim 1, characterized in that: The pectin-glucan solution is prepared by mixing and stirring pectin and glucan and water in a weight ratio of (1-3): (25-30): (60-80).

7. The water dispersible granules containing manganese substitute according to claim 1, characterized in that: The auxiliary agent includes at least one of a dispersant, a wetting agent and a thickener.

8. The water dispersible granules containing manganese substitute according to claim 6, characterized in that: The dispersant is selected from calcium lignin sulfonate; The wetting agent is selected from polysorbates; The thickener is selected from xanthan gum.

9. A method for preparing the water dispersible granules containing manganese substitute according to any one of claims 1 to 8, characterized in that: The preparation method comprises the following steps: mixing mancozeb microcapsules and auxiliary agents to obtain the water-dispersible granules containing mancozeb.

10. Use of the water dispersible granules containing manganese substitute according to claim 1 in the field of pesticides.

Images