Granules for enhancing immunity and preparation method thereof

Abstract

The invention discloses an immunity enhancing granule and a preparation method thereof, and belongs to the technical field of health care products. The method comprises the following steps: adding lucid ganoderma into a treating fluid for soaking, and then performing high-pressure heating treatment, drying and crushing to obtain lucid ganoderma powder; the preparation method comprises the following steps: adding lucid ganoderma powder into water, uniformly mixing, carrying out ultrasonic extraction, then adding papain, heating, extracting and filtering to obtain filtrate and filter residues, concentrating and drying the filtrate to obtain an extract I, carrying out supercritical extraction on the filter residues, adding an entrainer, filtering, concentrating and drying the extract to obtain an extract II, and carrying out freeze drying on the extract II to obtain the lucid ganoderma extract. Combining the extract I and the extract II to obtain the lucid ganoderma extract; and mixing the lucid ganoderma extract with auxiliary materials, granulating, drying and packaging to obtain the lucid ganoderma granule. The health-care granules disclosed by the invention are prepared by taking lucid ganoderma as a raw material, the bioavailability and the stability of active components in the granules are further improved by optimizing a preparation process, and the health-care granules have a very good effect of enhancing immunity.

Description

Technical Field

[0001] The invention belongs to the technical field of health care products, and particularly relates to immunity enhancing particles and a preparation method thereof. Background Art

[0002] In today's society, people are facing huge work pressure, life pressure, irregular diet and other factors, which lead to frequent sub-health problems, such as premature aging, insomnia, poor memory, listlessness and other symptoms. These sub-health problems not only seriously affect the quality of life and work efficiency of individuals, but also have a negative impact on social health, increase the consumption of medical resources and the burden of social costs. Therefore, it is imperative to improve the physical immunity of the whole people and fundamentally improve people's physical fitness. In addition to developing good living habits and maintaining moderate exercise, eating some corresponding health products is also an effective way to enhance immunity. In this context, it is particularly necessary to develop a health-care particle that can efficiently enhance immunity. This type of health-care particle can effectively supplement the nutrients needed by the human body, improve the function of the immune system, enhance the body's resistance, prevent and alleviate various sub-health symptoms, so that people can stay healthy, energetic and alive.

[0003] Lingzhi is a Chinese herbal medicine that is both a medicine and a food. It is rich in various active ingredients such as polysaccharides, triterpenes, and polyphenols, and has good health and food supplement effects. Studies have shown that Lingzhi has multiple biological activities such as antioxidant, anti-inflammatory, anti-tumor, and immune regulation, which can effectively improve the human immune function and enhance resistance. Therefore, health care particles developed with Lingzhi as the main raw material are expected to become an effective way to enhance immunity. However, some existing ganoderma lucidum health products still have some problems. For example, Chinese patent CN104095993A discloses a ganoderma lucidum granule for enhancing immunity and a preparation method thereof, which comprises the following steps: mixing ganoderma lucidum, codonopsis pilosula, astragalus, wolfberry and jujube with water and then decocting twice, filtering the combined decoction, vacuum concentrating, obtaining a concentrated solution, and mixing the concentrated solution with dextrin for high temperature granulation to obtain the obtained product; the patent adopts ganoderma lucidum and other four traditional Chinese medicines to extract, concentrate and granulate to obtain the granules, which has a certain effect of enhancing immunity, but the utilization rate of ganoderma lucidum is low, and due to the influence of the preparation process, the extract has problems such as low activity and poor stability, which makes the ganoderma lucidum granules unfavorable to maintain activity and efficacy over time during storage. Therefore, it is necessary to further improve the quality and effect of ganoderma lucidum health products by improving the process method and optimizing the components of health granules to meet people's needs for health, improve sub-health status, and enhance human immunity. Summary of the invention

[0004] In view of the deficiencies in the above-mentioned prior art, the present invention provides an immunity-enhancing granule, which uses Ganoderma lucidum as raw material, further improves the bioavailability and stability of the active ingredients in the Ganoderma lucidum health-care granule by improving and optimizing the process method, making it easier to absorb, and can effectively improve the sub-health state and enhance human immunity by long-term consumption. The present invention also provides a preparation method of the immunity-enhancing granule.

[0005] The technical solution adopted by the present invention is:

[0006] A method for preparing immunity enhancing granules comprises the following steps:

[0007] Step 1: adding Ganoderma lucidum to a treatment solution and soaking it, then subjecting it to high pressure heating treatment, drying it after completion, and crushing it to obtain Ganoderma lucidum powder; preferably, the treatment solution is composed of sulfuric acid, fucoidan sulfate and water;

[0008] Step 2: Add the ganoderma powder to water and mix evenly, add fucoidan sulfate, perform ultrasonic extraction, then add papain, perform heating extraction, filter after completion to obtain a filtrate and a filter residue, concentrate the filtrate, dry to obtain extract I, perform supercritical extraction on the filter residue, add an entrainer, filter, concentrate, and dry the extract after completion to obtain extract II, combine the extract I with the extract II to obtain a ganoderma extract;

[0009] Step 3: After mixing the Ganoderma lucidum extract with the auxiliary materials, granulating, drying and packaging are performed to obtain the immunity enhancing granules.

[0010] The present invention firstly soaks Ganoderma lucidum with a treatment solution composed of sulfuric acid, fucoidan sulfate and water and performs high-pressure heating treatment to break down the barriers of cell walls and cell membranes. This treatment is conducive to better dissolving the main active ingredients such as polysaccharides contained in Ganoderma lucidum in the subsequent extraction process, while ensuring that the active ingredients are not damaged and lost, thereby significantly improving the biological activity of Ganoderma lucidum extract. Secondly, the present invention sequentially performs ultrasonic extraction and enzyme heating extraction on Ganoderma lucidum powder, and then performs secondary supercritical extraction on the filter residue. This process can maximize the extraction of the main active ingredients such as polysaccharides, polyphenols and terpenes in Ganoderma lucidum, so that the final Ganoderma lucidum extract has higher biological activity and stronger antioxidant and immune enhancement capabilities, thereby ensuring that the efficacy of the health-care particles is stable and uniform.

[0011] In particular, in the treatment liquid and the subsequent extraction process, the present invention adds fucoidan sulfate as a protective auxiliary. This operation helps to reduce the loss of active ingredients such as polysaccharides, polyphenols and terpenes due to thermal instability, and retains the activity of ingredients such as polysaccharides, polyphenols and terpenes to the greatest extent. Fucoidan sulfate is a natural polysaccharide, which is widely present in the cell wall and intercellular matrix of brown algae, and has multiple advantages such as high-efficiency moisturizing, anti-oxidation, and biocompatibility. Its sulfonic acid group and polyhydroxy structure enable it to interact with other molecules to play a better protective and stabilizing role. This not only helps to form a stable hydration layer, wrap active ingredients such as polysaccharides, polyphenols and terpenes, prevent them from being damaged by thermal oxidation, mechanical pressure, etc., and improve the activity stability of the ganoderma lucidum extract, but also can interact with the active ingredients in ganoderma lucidum through hydrogen bonds and intermolecular forces, increase the dissolution of active ingredients in ganoderma lucidum, and improve the bioavailability of ganoderma lucidum.

[0012] Preferably, a method for preparing immunity enhancing granules comprises the following steps:

[0013] Step 1: Add Ganoderma lucidum to the treatment liquid at a solid-liquid ratio of 1kg:3-6L and soak for 80-120min, then heat under high pressure for 10-30min, vacuum dry after the treatment, and crush to 500-100 mesh to obtain Ganoderma lucidum powder;

[0014] Step 2: Add the Ganoderma lucidum powder to water at a solid-liquid ratio of 1kg:5-10L and mix evenly, add 0.6-1wt% fucoidan sulfate, perform ultrasonic extraction for 40-60min, then add 0.02-0.05wt% papain, heat and extract for 100-200min, filter after completion to obtain a filtrate and a filter residue, concentrate the filtrate, spray dry to obtain extract I, subject the filter residue to CO2 supercritical extraction for 70-100min, and add an entrainer, filter, concentrate, spray dry the extract after completion to obtain extract II, combine the extract I with the extract II to obtain a Ganoderma lucidum extract;

[0015] Step 3: Mix 70-90 wt % of the Ganoderma lucidum extract with the remainder as auxiliary materials, granulate, vacuum dry, and package to obtain the immunity enhancing granules.

[0016] Preferably, the Ganoderma lucidum is the dried fruiting body of Ganoderma lucidum (Leyss. ex Fr.) Karst or Ganoderma sinense Zhao, Xu et Zhang, of the Polyporaceae family.

[0017] The invention adopts mature ganoderma lucidum fruiting bodies without spore powder sprayed as raw materials, which are real ganoderma lucidum essences and contain all the nutritional components of ganoderma lucidum.

[0018] Preferably, the auxiliary material is one or a mixture of two or more of xylitol, maltitol, mannitol, oligofructose and isomaltose.

[0019] Preferably, the treatment solution in step 1 is composed of 0.5-2wt% sulfuric acid, 0.6-1wt% fucoidan sulfate and the remainder is water.

[0020] Preferably, the conditions for high pressure heating treatment in step 1 are: 0.5-2 MPa, 100-115°C.

[0021] Preferably, the conditions for ultrasonic extraction in step 2 are: 20-40kHz, 100-300W, 50-70°C.

[0022] Preferably, the conditions for heating extraction in step 2 are: 80-150 rpm, 50-60°C.

[0023] Preferably, the conditions for supercritical extraction in step 2 are: extraction pressure 30-45 MPa, temperature 40-50° C., and CO2 fluid flow rate 30-40 kg / h.

[0024] Preferably, in step 2, the entrainer is 70-95wt% edible alcohol, and the amount of the entrainer is 10-30wt% of the filter residue.

[0025] Preferably, the weight ratio of extract I to extract II in step 2 is 1:1-2.

[0026] The present invention also provides a particle for enhancing immunity, which is prepared by the above method.

[0027] The beneficial effects of the present invention are:

[0028] (1) The present invention provides a method for preparing immunity-enhancing granules, which uses Ganoderma lucidum as raw material. By improving and optimizing the process, the bioavailability and stability of the active ingredients in the Ganoderma lucidum health-care granules are further improved, making them easier to absorb. Long-term consumption can effectively improve sub-health conditions and enhance human immunity.

[0029] (2) The present invention sequentially performs ultrasonic extraction and enzyme heating extraction on the Ganoderma lucidum powder, and then performs secondary supercritical extraction on the filter residue, which can maximize the extraction of major active ingredients such as polysaccharides, polyphenols and terpenes in the Ganoderma lucidum, so that the final Ganoderma lucidum extract has higher biological activity and stronger antioxidant and immune enhancement capabilities, thereby ensuring that the efficacy of the health-care particles is stable and uniform. DETAILED DESCRIPTION

[0030] The following will be combined with the specific embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] The fucoidan sulfate used in the example was prepared according to the method described in paragraphs 0046-0050 of the specification of patent CN114014945B, as follows:

[0032] 5 kg of Fucus vesiculosus was washed with water to remove inorganic salts and other impurities on the surface, and then dried at 45° C. and crushed into 40-mesh Fucus vesiculosus powder; 0.2 kg of calcium hydroxide was added to 50 kg of water, and the mixture was stirred and mixed to form a calcium hydroxide aqueous solution, and then the calcium hydroxide aqueous solution was used as a solvent to extract the Fucus vesiculosus powder by atomization at 45° C. The atomization extraction time was 1 hour, and then filtered to obtain an extract; carbon dioxide was introduced into the extract to adjust the pH to 7.81, excess calcium hydroxide was precipitated, and filtered to obtain a filtrate; 1.86 kg of cation exchange resin (D001 resin) was added to the above filtrate for desalination, stirred at room temperature for 1 hour, filtered, and spray-dried to obtain fucoidan sulfate.

[0033] Example 1

[0034] A method for preparing immunity enhancing granules comprises the following steps:

[0035] Step 1: adding Ganoderma lucidum to a treatment solution at a solid-liquid ratio of 1kg:4.5L and soaking for 100 minutes, wherein the treatment solution is composed of 1.2wt% sulfuric acid, 0.8wt% fucoidan sulfate and the balance water, and then placing it under high pressure heating at 1.5MPa and 105°C for 20 minutes, and then vacuum drying and crushing to 800 meshes to obtain Ganoderma lucidum powder; wherein the Ganoderma lucidum adopts the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0036] Step 2: Add the Ganoderma lucidum powder to water at a solid-liquid ratio of 1kg:8L and mix evenly, add 0.8wt% fucoidan sulfate, perform ultrasonic extraction at 35kHz, 200W, and 65°C for 50min, then add 0.03wt% papain (800u / mg), heat and extract at 120rpm and 58°C for 150min, filter after completion to obtain a filtrate and a filter residue, concentrate the filtrate, spray dry to obtain extract I, subject the filter residue to CO2 supercritical extraction at an extraction pressure of 32Mpa and a temperature of 46°C for 80min, with a CO2 fluid flow rate of 35kg / h, and add an entrainer, filter the extract after completion, concentrate it, spray dry to obtain extract II, combine the extract I and extract II at a weight ratio of 1:1.5 to obtain a Ganoderma lucidum extract; wherein the entrainer is 85wt% edible alcohol, and the amount of the entrainer is 20wt% of the filter residue;

[0037] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0038] Example 2

[0039] A method for preparing immunity enhancing granules comprises the following steps:

[0040] Step 1: adding Ganoderma lucidum to a treatment solution at a solid-liquid ratio of 1kg:4.5L and soaking for 100 minutes, wherein the treatment solution is composed of 1.2wt% sulfuric acid and the remainder water, and then placing it under high pressure heating at 1.5MPa and 105°C for 20 minutes, and then vacuum drying and crushing to 800 meshes to obtain Ganoderma lucidum powder; wherein the Ganoderma lucidum adopts the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0041] Step 2: Add the Ganoderma lucidum powder to water at a solid-liquid ratio of 1kg:8L and mix evenly, perform ultrasonic extraction at 35kHz, 200W, and 65°C for 50min, then add 0.03wt% papain (800u / mg), heat and extract at 120rpm and 58°C for 150min, filter after completion to obtain a filtrate and a filter residue, concentrate the filtrate, spray-dry to obtain an extract I, subject the filter residue to CO2 supercritical extraction at an extraction pressure of 32Mpa and a temperature of 46°C for 80min, with a CO2 fluid flow rate of 35kg / h, and add an entrainer, filter the extract after completion, concentrate it, spray-dry to obtain an extract II, combine the extract I and extract II at a weight ratio of 1:1.5 to obtain a Ganoderma lucidum extract; wherein the entrainer is 85wt% edible alcohol, and the amount of the entrainer is 20wt% of the filter residue;

[0042] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0043] Example 3

[0044] A method for preparing immunity enhancing granules comprises the following steps:

[0045] Step 1: Grind the ganoderma lucidum into 800 meshes to obtain ganoderma lucidum powder; wherein the ganoderma lucidum is the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0046] Step 2: Add the Ganoderma lucidum powder to water at a solid-liquid ratio of 1kg:8L and mix evenly, add 0.8wt% fucoidan sulfate, perform ultrasonic extraction at 35kHz, 200W, and 65°C for 50min, then add 0.03wt% papain (800u / mg), heat and extract at 120rpm and 58°C for 150min, filter after completion to obtain a filtrate and a filter residue, concentrate the filtrate, spray dry to obtain extract I, subject the filter residue to CO2 supercritical extraction at an extraction pressure of 32Mpa and a temperature of 46°C for 80min, with a CO2 fluid flow rate of 35kg / h, and add an entrainer, filter the extract after completion, concentrate it, spray dry to obtain extract II, combine the extract I and extract II at a weight ratio of 1:1.5 to obtain a Ganoderma lucidum extract; wherein the entrainer is 85wt% edible alcohol, and the amount of the entrainer is 20wt% of the filter residue;

[0047] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0048] Example 4

[0049] A method for preparing immunity enhancing granules comprises the following steps:

[0050] Step 1: adding Ganoderma lucidum to a treatment solution at a solid-liquid ratio of 1kg:4.5L and soaking for 100 minutes, wherein the treatment solution is composed of 1.2wt% sulfuric acid, 0.8wt% fucoidan sulfate and the balance water, and then placing it under high pressure heating at 1.5MPa and 105°C for 20 minutes, and then vacuum drying and crushing to 800 meshes to obtain Ganoderma lucidum powder; wherein the Ganoderma lucidum adopts the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0051] Step 2: Add the Ganoderma lucidum powder into water at a solid-liquid ratio of 1kg:8L and mix well, add 0.8wt% fucoidan sulfate, perform ultrasonic extraction at 35kHz, 200W, and 65°C for 50min, then add 0.03wt% papain (800u / mg), heat and extract at 120rpm and 58°C for 150min, filter after the extraction, concentrate the filtrate, and spray dry to obtain the Ganoderma lucidum extract;

[0052] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0053] Example 5

[0054] A method for preparing immunity enhancing granules comprises the following steps:

[0055] Step 1: adding Ganoderma lucidum to a treatment solution at a solid-liquid ratio of 1kg:4.5L and soaking for 100 minutes, wherein the treatment solution is composed of 1.2wt% sulfuric acid, 0.8wt% fucoidan sulfate and the balance water, and then placing it under high pressure heating at 1.5MPa and 105°C for 20 minutes, and then vacuum drying and crushing to 800 meshes to obtain Ganoderma lucidum powder; wherein the Ganoderma lucidum adopts the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0056] Step 2: subjecting the ganoderma lucidum powder to CO2 supercritical extraction at an extraction pressure of 32 MPa and a temperature of 46° C. for 80 minutes, with a CO2 fluid flow rate of 35 kg / h, and adding an entrainer, after which the extract is filtered, concentrated, and spray-dried to obtain a ganoderma lucidum extract; wherein the entrainer is 85 wt % edible alcohol, and the amount of the entrainer is 20 wt % of the filter residue;

[0057] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0058] Comparative Example

[0059] A method for preparing immunity enhancing granules comprises the following steps:

[0060] Step 1: Grind the ganoderma lucidum into 800 meshes to obtain ganoderma lucidum powder; wherein the ganoderma lucidum is the dried fruiting body of the fungus Ganoderma lucidum of the Polyporaceae family;

[0061] Step 2: Add the Ganoderma lucidum powder into water at a solid-liquid ratio of 1kg:8L and mix well, perform ultrasonic extraction at 35kHz, 200W, and 65°C for 50min, then add 0.03wt% papain (800u / mg), heat and extract at 120rpm and 58°C for 150min, filter after the extraction, concentrate the filtrate, and spray dry to obtain the Ganoderma lucidum extract;

[0062] Step 3: 80 wt% of the Ganoderma lucidum extract and 20 wt% of the auxiliary material xylitol are mixed and granulated, vacuum dried, and packaged to obtain the immunity enhancing granules.

[0063] Test Example 1

[0064] The test subjects were elderly patients suffering from various chronic diseases (diagnosed as patients with lung qi deficiency syndrome), who orally took the immunity enhancing granules prepared in the above-mentioned embodiment 1 and the comparative example, 5 g each time, 3 times a day. One month was a course of treatment, and there were 3 courses of treatment in total. Routine blood, urine, and stool tests and heart and lung function tests were performed, and fever, aversion to cold, nasal symptoms, pharyngeal symptoms, and general conditions were observed, as well as changes in body temperature, pharyngeal tonsils, tongue and pulse, etc., and the efficacy was evaluated.

[0065] Table 1. Improvement of immunity function in Example 1 and comparative examples

[0066] Number of cases Significant improvement improve invalid Total improvement rate Example 1 100 85 6 9 91％ Comparative Example 100 33 13 54 46％

[0067] Test Example 2

[0068] The scavenging rate of the Ganoderma lucidum extracts obtained in the above examples on superoxide anion free radicals was determined by the light riboflavin method. 0.092M NBT solution, 0.0167M riboflavin solution and 10M methionine solution were prepared using 50M PBS buffer with pH=7.4 as solvent. 2mL of the above three solutions were taken respectively, and 0.05g of Ganoderma lucidum extract was added to each solution and mixed evenly. The mixture was placed in a light box for 0.5h and the absorbance A was measured after the solution was taken out. 560nm PBS buffer was used as a blank control (A0). The clearance rate of each example and the growth rate of the antioxidant activity of the Ganoderma lucidum extract obtained in Examples 1-5 compared with the Ganoderma lucidum extract obtained in the comparative example were calculated according to the following formula. Five groups were paralleled and the average value was taken. Clearance rate Y% = (A0-A 样 ) / A0×100%;Antioxidant activity growth rate %=(Y 实施例 -Y 对比例 ) / Y 对比例 ×100%.

[0069] Table 2. Growth rate of antioxidant activity of Examples 1-5

[0070] Antioxidant activity growth rate Example 1 14.6％ Example 2 12.3％ Example 3 8.1％ Example 4 6.0％ Example 5 4.5％

[0071] It can be seen that the ganoderma lucidum extract and health-care granules corresponding to Example 1 of the present invention have the best antioxidant activity and immunity-enhancing effect. The possible reason is that the present invention first uses a treatment solution composed of sulfuric acid, fucoidan sulfate and water to soak the ganoderma lucidum and perform high-pressure heating treatment, which is conducive to better dissolving the main active ingredients such as polysaccharides contained in the ganoderma lucidum in the subsequent extraction process, while ensuring that the active ingredients are not damaged and lost, thereby significantly improving the biological activity of the ganoderma lucidum extract. Secondly, the ganoderma lucidum powder is subjected to ultrasonic extraction and enzyme heating extraction in sequence, and then the filter residue is subjected to secondary supercritical extraction, which can maximize the extraction of the main active ingredients such as polysaccharides, polyphenols and terpenes in the ganoderma lucidum, so that the final ganoderma lucidum extract has higher biological activity and stronger antioxidant and immune-enhancing ability, thereby ensuring that the efficacy of the health-care granules is stable and uniform. In particular, the present invention adds fucoidan sulfate as a protective auxiliary agent in the treatment solution and the subsequent extraction process, which helps to reduce the loss of active ingredients such as polysaccharides, polyphenols and terpenes due to thermal instability, and retains the activity of ingredients such as polysaccharides, polyphenols and terpenes to the greatest extent. Fucoidan sulfate has many advantages such as high-efficiency moisturizing, anti-oxidation, and biocompatibility. Its sulfonic acid group and polyhydroxy structure enable it to interact with other molecules to exert better protection and stabilization. It not only helps to form a stable hydration layer, wraps active ingredients such as polysaccharides, polyphenols and terpenes, and prevents them from being damaged by thermal oxidation, mechanical pressure, etc., thereby improving the activity stability of Ganoderma lucidum extract, but also can interact with the active ingredients in Ganoderma lucidum through hydrogen bonds and intermolecular forces, thereby increasing the dissolution of active ingredients in Ganoderma lucidum and improving the bioavailability of Ganoderma lucidum.

[0072] The preferred specific embodiments of the present invention are described in detail above. It should be understood that a person skilled in the art can make many modifications and changes based on the concept of the present invention without creative work. Therefore, any technical solution that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the concept of the present invention on the basis of the prior art should be within the scope of protection determined by the claims.

Claims

1. A method for preparing immunity enhancing granules, characterized in that: The steps include: Step 1: adding Ganoderma lucidum to the treatment solution and soaking it, then subjecting it to high pressure heating treatment, drying it after completion, and crushing it to obtain Ganoderma lucidum powder; Step 2: adding ganoderma lucidum powder to water and mixing evenly, ultrasonically extracting, then adding papain, heating and extracting, filtering after completion to obtain a filtrate and a filter residue, concentrating the filtrate, drying to obtain extract I, subjecting the filter residue to supercritical extraction, and adding an entrainer, filtering, concentrating, and drying the extract after completion to obtain extract II, combining the extract I with the extract II to obtain a ganoderma lucidum extract; Step 3: After mixing the Ganoderma lucidum extract with the auxiliary materials, granulating, drying and packaging are performed to obtain the immunity enhancing granules.

2. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: The treatment solution in step 1 is composed of 0.5-2wt% sulfuric acid, 0.6-1wt% fucoidan sulfate and the balance is water.

3. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: In step 2, 0.6-1 wt % of fucoidan sulfate can also be added before ultrasonic extraction.

4. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: The auxiliary material is one or a mixture of two or more of xylitol, maltitol, mannitol, oligofructose and isomaltooligosaccharide.

5. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: The conditions of high pressure heating treatment in step 1 are: 0.5-2MPa, 100-115°C.

6. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: The conditions for ultrasonic extraction in step 2 are: 100-300W, 50-70°C.

7. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: The conditions of supercritical extraction in step 2 are: extraction pressure 30-45Mpa, temperature 40-50°C.

8. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: In step 2, the entrainer is 70-95wt% edible alcohol, and the amount of the entrainer is 10-30wt% of the filter residue.

9. The method for preparing the immunity enhancing granules according to claim 1, characterized in that: In step 3, the ganoderma lucidum extract accounts for 70-90wt% of the total amount.

10. An immunity enhancing granule, characterized in that: The method is prepared by the method according to any one of claims 1 to 9.