Pulse ablation device

Abstract

According to the pulse ablation device, a multi-cavity tube is arranged in a catheter, a first line cavity, a second line cavity and a third line cavity are formed in the multi-cavity tube, a spring tube is arranged in the catheter and arranged on the peripheral face of the outer side of the multi-cavity tube in a sleeving mode, a fixing base is arranged at the far end of the catheter, and the near end of the fixing base is fixed to the far end of the multi-cavity tube; the electrode tip is arranged on the side, back on to the multi-cavity tube, of the fixing base and used for being fixed to target tissue. The electrode assembly comprises a first electrode and a second electrode; the first wire is arranged in the first wire cavity and electrically connected with the first electrode, the second wire is arranged in the second wire cavity and electrically connected with the second electrode, the third wire is arranged in the third wire cavity and electrically connected with the electrode tip, and the first electrode and the second electrode are located between the fixing base and the far end of the spring tube. The far end of the bourdon tube and any one of the first electrode and the second electrode are arranged at intervals in the axial direction of the catheter, and any two of the electrode tip, the first electrode and the second electrode can discharge at the same time and are opposite in electrical property.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a pulse ablation device. Background Art

[0002] Atrial fibrillation (atrial arrhythmia) is the most common arrhythmia, with symptoms of irregular heart beats. The incidence of atrial fibrillation in the general population is 0.5% to 1.5%. According to statistics, there are 33.5 million patients with atrial fibrillation worldwide, and there are about 8 million patients with atrial fibrillation in my country. The risk of stroke in patients with atrial fibrillation is very high. In China, stroke is one of the important causes of death, and stroke caused by atrial fibrillation usually has more severe clinical manifestations, higher mortality, and is more likely to recur. Therefore, the treatment of atrial fibrillation cannot be delayed.

[0003] Pulse ablation is a new non-thermal ablation technology for the treatment of atrial fibrillation. This technology uses a high-voltage pulse electric field to form temporary electroporation on the cell membrane, leading to cell apoptosis, thereby achieving ablation of the target tissue. Pulse ablation technology has the advantages of high precision, low damage and rapid recovery, and has been widely used in cardiac treatment and minimally invasive surgery. The pulse ablation catheter is the key equipment for pulse ablation. It transmits the pulse electric field to the target tissue through the catheter to achieve ablation of the tissue.

[0004] However, when a conventional pulse ablation catheter enters the body and contacts the target tissue, the electrode arrangement at the distal end of the catheter is restricted within the limited contact area, resulting in insufficient ablation area and affecting the ablation effect.

[0005] BACKGROUND OF THE PRESENT APPLICATION The above information disclosed is only used to understand the background of the concept of the present application, and does not indicate or imply that it contains information of the prior art. Summary of the invention

[0006] Based on this, it is necessary to provide a pulse ablation device to address the above problems.

[0007] The present application provides a pulse ablation device, comprising:

[0008] catheter;

[0009] A multi-lumen tube is disposed in the catheter, wherein a first line lumen, a second line lumen and a third line lumen are formed in the multi-lumen tube;

[0010] A spring tube is arranged in the catheter and sleeved on the outer peripheral surface of the multi-lumen tube;

[0011] A fixing seat, disposed at the distal end of the catheter, wherein the proximal end of the fixing seat is fixed to the distal end of the multi-lumen tube;

[0012] An electrode head, disposed on a side of the fixing seat facing away from the multi-lumen tube and used for fixing to a target tissue;

[0013] An electrode assembly, comprising a first electrode and a second electrode spaced apart from each other, wherein the first electrode and the second electrode are both disposed on an outer peripheral surface of the distal end of the catheter;

[0014] A first wire is disposed in the first wire cavity and a distal end of the first wire is electrically connected to the first electrode;

[0015] A second wire is disposed in the second wire cavity and a distal end of the second wire is electrically connected to the second electrode;

[0016] A third wire is disposed in the third wire cavity and a distal end of the third wire is electrically connected to the electrode head;

[0017] The first electrode and the second electrode are located between the fixing seat and the distal end of the spring tube, and the distal end of the spring tube is spaced apart from any one of the first electrode and the second electrode in the axial direction of the catheter, and any two of the electrode head, the first electrode and the second electrode can discharge simultaneously and have opposite electrical properties.

[0018] Before describing the beneficial effects that can be achieved by the pulse ablation device of the present application, it should be noted that according to many current literatures, animal experiments, and human experiments, the ablation effect of pulse ablation depends on the combined effect of multiple factors, among which the electric field size is affected by the electrode size and spacing. The closer to the electrode, the stronger the electric field effect, and the electric field strength gradually decays as the distance from the electrode increases. The smaller the electrode size, the faster the field strength decays with increasing distance, and the tissue ablation effect also decreases accordingly.

[0019] In the face of the above background, the pulse ablation device of the present application can at least achieve the following beneficial effects: the present application optimizes the electrode arrangement, the interval setting between the electrode head and the multiple electrodes on the outer peripheral surface of the distal end of the catheter, any two of the electrode head, the first electrode and the second electrode can discharge at the same time and have opposite electrical properties, and can form an effective electric field in a larger range, thereby achieving more uniform tissue ablation and avoiding the problem of insufficient local ablation. This also means that the ablation process is more efficient, thereby reducing the operation time and the patient's pain, and helping to improve the overall treatment efficiency. The independent wire cavity design in the multi-lumen tube makes the wire arrangement more orderly and compact, reduces the possibility of wire entanglement or knotting during the operation, and also ensures electrical isolation between the wires, avoids signal interference and short circuit problems, and improves the safety and reliability of the device. The structural design of adding a fixing seat and arranging the electrode head on the side of the fixing seat facing away from the multi-lumen tube enables the electrode head to be firmly installed at the distal end of the catheter, ensuring that the electrode head will not loosen or shift during the operation, improves the structural stability of the entire device, and reduces the error caused by the movement of the catheter during the operation. In addition, the distal end of the multi-lumen tube is also connected to the fixing seat, which can also improve the stability of the relative position of the multi-lumen tube in the catheter, ensuring that the electrical energy can be efficiently and reliably transmitted to the electrode head for pulse ablation. Among them, the spring tube can provide additional structural support, improve the structural stability of the catheter and the multi-lumen tube, and reduce the shaking or displacement that may occur during operation. The elastic properties of the spring tube make the catheter have a certain flexibility during operation, which can better adapt to the complex anatomical structure in the human body and improve the flexibility and accuracy of operation. Since the spring tube has a certain elasticity, it can increase the transmission of torque to the distal end of the catheter during proximal manipulation, improve the maneuverability of the catheter, and facilitate the screwing of the electrode head into the target tissue. In addition, the spring tube is mostly made of metal, so the design of the distal end of the spring tube and the first electrode and the second electrode is spaced apart, that is, the distal end of the spring tube is far away from the electrode, which ensures that the electrode will not be interfered by the spring tube during operation, and can avoid the situation where the distal end of the spring tube and the electrode are connected due to high voltage.

[0020] In one embodiment, the fixing seat includes a main body and a protrusion connected to the main body, the protrusion is arranged at the distal end of the main body, the electrode head fixing sleeve is arranged on the outer circumference of the protrusion, and the proximal end of the main body is provided with a receiving cavity, and the receiving cavity is used to fix and communicate with the distal end of the multi-lumen tube. The protrusion design of the fixing seat provides a stable structure so that the electrode head can be firmly fixed. The proximal end of the main body is provided with a receiving cavity, and the receiving cavity design of the fixing seat makes it easier to connect with the multi-lumen tube and facilitate installation.

[0021] In one embodiment, the third wire is passed through the fixing seat and electrically connected to the electrode head, so as to ensure that the electric energy can be efficiently and reliably transmitted to the electrode head for pulse ablation.

[0022] In one embodiment, the electrode head is spirally shaped and can be rotated under the drive of the catheter to drill into and fix to the target tissue. The spiral electrode head can rotate under the drive of the catheter to drill into the target tissue, thereby achieving a firm fixation. This design not only ensures that the electrode head will not be easily displaced during the ablation process, but also provides a better fixation effect in irregular or harder tissues. And because the electrode head can penetrate deep into the target tissue, the ablation effect is enhanced. The spiral design increases the contact area between the electrode head and the tissue, allowing the electrical energy to be more evenly transmitted to the target area, thereby improving the ablation efficiency and effect.

[0023] In one embodiment, the distal end of the multi-lumen tube is exposed from the spring tube to be connected to the fixing seat.

[0024] In one embodiment, the first electrode and the second electrode are both annular and are sleeved on the outer peripheral surface of the distal end of the catheter, and the first electrode and the second electrode are spaced apart in the axial direction of the catheter. The annular electrode covers the outer peripheral surface of the catheter, providing a larger contact area, which helps to improve the efficiency of electrical energy conduction, thereby improving the ablation efficiency. The design of the annular electrode also makes the electric field distribution more uniform, which helps to improve the ablation effect, ensure that the target tissue can be subjected to a uniform electric field, and reduce the occurrence of unablated areas.

[0025] In one of the embodiments, the thickness of the first electrode in the radial direction of the catheter is 0.05 mm-0.3 mm.

[0026] In one of the embodiments, the width of the first electrode in the axial direction of the catheter is 0.75 mm-4.5 mm.

[0027] In one of the embodiments, the thickness of the second electrode in the radial direction of the catheter is 0.05 mm-0.3 mm.

[0028] In one embodiment, the width of the second electrode in the axial direction of the catheter is 0.75 mm-4.5 mm.

[0029] In one embodiment, the first electrode and the second electrode are both tile-shaped and arranged at intervals on the outer peripheral surface of the catheter along the circumference of the catheter. The tile-shaped first electrode and the second electrode are arranged at intervals along the circumference of the catheter, providing a larger contact area and ensuring uniform distribution of the electric field in the target area, which helps to improve the efficiency of electric energy conduction, thereby improving the ablation efficiency and ablation effect.

[0030] In one embodiment, the first electrode and the second electrode are located in a corresponding position in the axial direction of the catheter. Since the first electrode and the second electrode are located in a corresponding position in the axial direction, more accurate electric field positioning can be achieved, so that the electric field between the two electrodes is stronger and more concentrated, and electric energy can be conducted more effectively, thereby improving ablation efficiency.

[0031] In one embodiment, the positions of the first electrode and the second electrode in the axial direction of the catheter are at least partially staggered. Since the positions of the first electrode and the second electrode in the axial direction of the catheter are at least partially staggered, the range of action of the electric field is expanded, a larger target area can be covered, and the ablation effect is improved.

[0032] In one embodiment, the angle of the first electrode in the circumferential direction of the catheter is 45° to 160°.

[0033] In one of the embodiments, the thickness of the first electrode in the radial direction of the catheter is 0.05 mm-0.3 mm.

[0034] In one embodiment, the width of the first electrode in the axial direction of the catheter is 1.5 mm-12 mm.

[0035] In one embodiment, the included angle of the second electrode in the circumferential direction of the catheter is 45° to 160°.

[0036] In one of the embodiments, the thickness of the second electrode in the radial direction of the catheter is 0.05 mm-0.3 mm.

[0037] In one embodiment, the width of the second electrode in the axial direction of the catheter is 1.5 mm-12 mm.

[0038] In one embodiment, the first electrode and the second electrode are both spirally shaped and staggeredly coiled on the outer peripheral surface of the distal end of the catheter. Such a structural design makes the electric field more evenly distributed in the target tissue, which helps to improve the uniformity and thoroughness of ablation. The effective ablation range can be maintained even at low voltage, and the spiral structure can always ablate the surrounding tissue, and the ablation range also increases with the increase of voltage.

[0039] In one embodiment, both the first electrode and the second electrode are flexible electrodes. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0041] Figure 1 A schematic structural diagram of a pulse ablation device provided in one embodiment of the present invention.

[0042] Figure 2 A partial cross-sectional view of a pulse ablation device provided in one embodiment of the present invention.

[0043] Figure 3 A partial schematic diagram of a pulse ablation device provided in accordance with an embodiment of the present invention without showing a catheter.

[0044] Figure 4 A partial schematic diagram of a pulse ablation device provided by an embodiment of the present invention.

[0045] Figure 5 For the present invention Figure 4 A cross-sectional view of the pulse ablation device at the AA line.

[0046] Figure 6 A schematic structural diagram of a fixing base provided in one embodiment of the present invention.

[0047] Figure 7 A schematic structural diagram of a pulse ablation device provided in the first embodiment of the present invention.

[0048] Figure 8 This is a comsol verification image of the pulse ablation device provided in the first embodiment of the present invention.

[0049] Fig. 9 A schematic structural diagram of a pulse ablation device provided in a second embodiment of the present invention.

[0050] Fig.10 This is a comsol verification image of the pulse ablation device provided in the second embodiment of the present invention.

[0051] Fig.11 A schematic structural diagram of a pulse ablation device provided in a third embodiment of the present invention.

[0052] Fig.12This is a comsol verification image of the pulse ablation device provided in the third embodiment of the present invention.

[0053] Fig.13 A schematic structural diagram of a pulse ablation device provided in a fourth embodiment of the present invention.

[0054] Fig.14 This is a comsol verification image of the pulse ablation device provided in the fourth embodiment of the present invention.

[0055] Fig.15 The pulse ablation device provided in the first embodiment of the present invention verifies the image with a comsol of 100V to 600V.

[0056] Fig.16 The pulse ablation device provided in the fourth embodiment of the present invention verifies the image with 100V~600V comsol.

[0057] Reference numerals:

[0058] 10. Pulse ablation device; 100. Catheter; 200. Electrode head; 300. Electrode assembly; 310. First electrode; 320. Second electrode; 400. Handle; 500. Multi-lumen tube; 510. First line cavity; 520. Second line cavity; 530. Third line cavity; 600. Fixing seat; 610. Main body; 611. Receiving cavity; 620. Protrusion; 700. Spring tube. DETAILED DESCRIPTION

[0059] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0060] In the present application, the “proximal end” may be considered as the end close to the operator, and the “distal end” may be considered as the end far away from the operator.

[0061] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5In some embodiments, the present application provides a pulse ablation device 10, which includes a catheter 100, an electrode head 200, an electrode assembly 300, and a handle 400. The proximal end of the catheter 100 is connected to the handle 400, and the distal end of the catheter 100 is connected to the electrode head 200, and the electrode head 200 can be fixed to the target tissue. The electrode assembly 300 includes a first electrode 310 and a second electrode 320 spaced apart from each other, and the first electrode 310 and the second electrode 320 are both arranged on the outer peripheral surface of the distal end of the catheter 100. Among them, any two of the electrode head 200, the first electrode 310 and the second electrode 320 can discharge at the same time and have opposite electrical properties.

[0062] Before describing the beneficial effects that can be achieved by the pulse ablation device 10 of the present application, it should be noted that, according to many current literatures, animal experiments, and human experiments, the ablation effect of pulse ablation depends on the combined effect of multiple factors, among which the electric field size is affected by the electrode size and spacing. The closer to the electrode, the stronger the electric field effect, and the electric field strength gradually decays as the distance from the electrode increases. The smaller the electrode size, the faster the field strength decays with increasing distance, and the tissue ablation effect also decreases accordingly.

[0063] In the face of the above background, the pulse ablation device 10 of the present application can at least achieve the following beneficial effects: the present application optimizes the electrode arrangement, the spacing between the electrode head 200 and the multiple electrodes on the outer peripheral surface of the distal end of the catheter 100, any two of the electrode head 200, the first electrode 310 and the second electrode 320 can discharge at the same time and have opposite electrical properties, and can form an effective electric field in a larger range, thereby achieving more uniform tissue ablation and avoiding the problem of insufficient local ablation. This also means that the ablation process is more efficient, thereby reducing the operation time and the patient's pain, and helping to improve the overall treatment efficiency.

[0064] Specifically, Figure 2 , Figure 3 and Figure 5As shown, in some embodiments, the pulse ablation device 10 further includes a first wire, a second wire, a third wire (not shown) and a multi-lumen tube 500 disposed in the catheter 100, wherein the multi-lumen tube 500 is formed with a first wire cavity 510, a second wire cavity 520 and a third wire cavity 530, wherein the first wire is disposed in the first wire cavity 510 and the distal end of the first wire is electrically connected to the first electrode 310, the second wire is disposed in the second wire cavity 520 and the distal end of the second wire is electrically connected to the second electrode 320, and the third wire is disposed in the third wire cavity 530 and the distal end of the third wire is electrically connected to the electrode head 200. The independent wire cavity design in the multi-lumen tube 500 makes the wire arrangement more orderly and compact, reduces the possibility of wire entanglement or knotting during surgery, and also ensures electrical isolation between the wires, avoids signal interference and short circuit problems, and improves the safety and reliability of the device. The material of the multi-lumen tube 500 may include but is not limited to PEBAX (polyether block polyamide), PTFE (polytetrafluoroethylene), TPU (thermoplastic polyurethane elastomer), PVC (polyvinyl chloride) and other polymer materials.

[0065] Specifically, Figure 2 , Figure 3 and Figure 6 As shown, in some embodiments, the pulse ablation device 10 further includes a fixing seat 600, the fixing seat 600 is arranged at the distal end of the catheter 100, the proximal end of the fixing seat 600 is fixed to the distal end of the multi-lumen tube 500, the electrode head 200 is arranged on the side of the fixing seat 600 facing away from the multi-lumen tube 500, and the third wire is passed through the fixing seat 600 and electrically connected to the electrode head 200. Among them, the fixing seat 600 can be an insulating fixing seat 600 made of insulating material. The structural design of adding a fixing seat 600 and arranging the electrode head 200 on the side of the fixing seat 600 facing away from the multi-lumen tube 500 enables the electrode head 200 to be firmly installed at the distal end of the catheter 100, ensuring that the electrode head 200 will not loosen or shift during operation, improving the structural stability of the entire device, and reducing errors caused by the movement of the catheter 100 during surgery. In addition, the distal end of the multi-lumen tube 500 is also connected to the fixing seat 600, which can also improve the stability of the relative position of the multi-lumen tube 500 in the catheter 100, and the third wire is passed through the fixing seat 600 and electrically connected to the electrode head 200, ensuring that electrical energy can be efficiently and reliably transmitted to the electrode head 200 for pulse ablation.

[0066] Specifically, Figure 3 and Figure 4As shown, in some embodiments, the electrode head 200 is spiral and can be rotated under the drive of the catheter 100 to drill into and fix to the target tissue. The spiral electrode head 200 can be rotated under the drive of the catheter 100 to drill into the target tissue, thereby achieving a firm fixation. When the electrode head 200 drills into the target tissue, the electrode head 200 can be mutually supported by the target tissue around it, and will not move in the axial and radial directions, so that the electrode head 200 can be reliably fixed in the target tissue. After the ablation of a target tissue target point is completed, the electrode head 200 can be rotated out through the catheter 100 to allow the electrode head 200 to be separated from the target tissue, and then the electrode head 200 can be reused to drill into the next target point for ablation until all target tissue target points are ablated. This design not only ensures that the electrode head 200 will not be easily displaced during the ablation process, but also provides a better fixation effect in irregular or harder tissues. And because the electrode head 200 can penetrate into the target tissue, the ablation effect is enhanced. The spiral design increases the contact area between the electrode head 200 and the tissue, so that the electrical energy can be more evenly transmitted to the target area, thereby improving the ablation efficiency and effect. Among them, the electrode head 200 can be made of conductive materials, and the conductive materials include but are not limited to metals such as platinum-iridium alloy, gold, nickel-cobalt-chromium-molybdenum alloy, stainless steel, and titanium alloy. The electrode head 200 also acts as an electrode, which can release pulse energy. After drilling into the target tissue, it works together with the electrode assembly 300 to achieve pulse ablation of the target tissue.

[0067] More specifically, if Figure 2 , Figure 3 and Figure 6 As shown, in some embodiments, the fixing seat 600 includes a main body 610 and a protrusion 620 connected to the main body 610, the protrusion 620 is arranged at the distal end of the main body 610, the electrode head 200 is fixedly sleeved on the outer peripheral surface of the protrusion 620, and the proximal end of the main body 610 is provided with a receiving cavity 611, and the receiving cavity 611 is used to be fixed and communicated with the distal end of the multi-lumen tube 500. The protrusion 620 design of the fixing seat 600 provides a stable structure, so that the electrode head 200 can be firmly fixed. The proximal end of the main body 610 is provided with a receiving cavity 611, and the receiving cavity 611 design of the fixing seat 600 makes it easier to connect with the multi-lumen tube 500 and facilitate installation.

[0068] See also Figure 2 and Figure 3In some embodiments, the pulse ablation device 10 further includes a spring tube 700 disposed in the catheter 100, the spring tube 700 is sleeved on the outer peripheral surface of the multi-lumen tube 500, the distal end of the multi-lumen tube 500 is exposed from the spring tube 700 to be connected with the fixing seat 600, the first electrode 310 and the second electrode 320 are located between the fixing seat 600 and the distal end of the spring tube 700, and the distal end of the spring tube 700 is spaced from either the first electrode 310 or the second electrode 320 in the axial direction of the catheter 100. The spring tube 700 can provide additional structural support, improve the structural stability of the catheter 100 and the multi-lumen tube 500, and reduce the shaking or displacement that may occur during operation. The elastic characteristics of the spring tube 700 make the catheter 100 have a certain flexibility during operation, can better adapt to the complex anatomical structure in the human body, and improve the flexibility and accuracy of operation. Since the spring tube 700 has a certain elasticity, the transmission of torque to the distal end of the catheter 100 during proximal manipulation can be increased, the manipulability of the catheter 100 is improved, and the electrode head 200 is easily screwed into the target tissue. In addition, the spring tube 700 is mostly made of metal, so the design of the distal end of the spring tube 700 being spaced from the first electrode 310 and the second electrode 320, that is, the distal end of the spring tube 700 is far away from the electrodes, can avoid the situation where the distal end of the spring tube 700 and the first electrode 310 and the second electrode 320 are connected due to high voltage.

[0069] A variety of embodiments are further provided below to illustrate various structures and arrangements of the electrode assembly 300 , which is intended to further clarify the technical solution of the present application, and does not indicate or imply a specific limitation on the electrode assembly 300 .

[0070] See also Figure 7 and Figure 8 In a first embodiment, the first electrode 310 and the second electrode 320 of the electrode assembly 300 are both annular and are sleeved on the outer circumferential surface of the distal end of the catheter 100. The first electrode 310 and the second electrode 320 are spaced apart in the axial direction of the catheter 100. For example, the spacing between the first electrode 310 and the second electrode 320 in the axial direction of the catheter 100 may be about 4 mm, which is only used as an example here, and other sizes may also be used. The annular electrode covers the outer circumferential surface of the catheter 100, providing a larger contact area, which helps to improve the efficiency of electrical energy conduction, thereby improving the ablation efficiency. The design of the annular electrode also makes the electric field distribution more uniform, which helps to improve the ablation effect, ensure that the target tissue can be subjected to a uniform electric field, and reduce the occurrence of unablated areas.

[0071] Further, in the first embodiment, the thickness of the first electrode 310 in the radial direction of the catheter 100 is 0.05 mm-0.3 mm, and the width of the first electrode 310 in the axial direction of the catheter 100 is 0.75 mm-4.5 mm.

[0072] Furthermore, in the first embodiment, the thickness of the first electrode 310 in the radial direction of the catheter 100 is 0.1 mm, and the width of the first electrode 310 in the axial direction of the catheter 100 is 2 mm.

[0073] Further, in the first embodiment, the thickness of the second electrode 320 in the radial direction of the catheter 100 is 0.05 mm-0.3 mm, and the width of the second electrode 320 in the axial direction of the catheter 100 is 0.75 mm-4.5 mm.

[0074] Furthermore, in the first embodiment, the thickness of the second electrode 320 in the radial direction of the catheter 100 is 0.1 mm, and the width of the second electrode 320 in the axial direction of the catheter 100 is 2 mm.

[0075] See also Fig. 9 and Fig.10 In the second embodiment, the first electrode 310 and the second electrode 320 are both tile-shaped and are arranged at intervals on the outer peripheral surface of the catheter 100 along the circumference of the catheter 100, and the positions of the first electrode 310 and the second electrode 320 in the axial direction of the catheter 100 correspond. Such a setting can be roughly considered that the projections of the first electrode 310 and the second electrode 320 in the radial direction of the catheter 100 are aligned. The tile-shaped first electrode 310 and the second electrode 320 are arranged at intervals along the circumference of the catheter 100, providing a larger contact area and ensuring the uniform distribution of the electric field in the target area, which helps to improve the efficiency of electric energy conduction. Since the positions of the first electrode 310 and the second electrode 320 in the axial direction correspond, more accurate electric field positioning can be achieved, making the electric field between the two electrodes stronger and more concentrated, and can more effectively conduct electric energy, thereby improving the ablation efficiency.

[0076] Further, in the second embodiment, the angle of the first electrode 310 in the circumferential direction of the catheter 100 is 45°-160°, the thickness of the first electrode 310 in the radial direction of the catheter 100 is 0.05mm-0.3mm, and the width of the first electrode 310 in the axial direction of the catheter 100 is 1.5mm-12mm.

[0077] Further, in the second embodiment, the angle of the second electrode 320 in the circumferential direction of the catheter 100 is 45°-160°, the thickness of the second electrode 320 in the radial direction of the catheter 100 is 0.05mm-0.3mm, and the width of the second electrode 320 in the axial direction of the catheter 100 is 1.5mm-12mm.

[0078] See also Fig.11 and Fig.12In the third embodiment, the first electrode 310 and the second electrode 320 are both tile-shaped and are arranged at intervals on the outer peripheral surface of the catheter 100 along the circumference of the catheter 100, and the positions of the first electrode 310 and the second electrode 320 in the axial direction of the catheter 100 are at least partially staggered. Such a setting can be roughly considered that the projections of the first electrode 310 and the second electrode 320 in the radial direction of the catheter 100 are only partially overlapped and misaligned. Since the positions of the first electrode 310 and the second electrode 320 in the axial direction of the catheter 100 are at least partially staggered, the range of action of the electric field is expanded, and a larger target area can be covered, thereby improving the ablation effect.

[0079] Furthermore, in the third embodiment, the angle of the first electrode 310 in the circumferential direction of the catheter 100 is 45°-160°, the thickness of the first electrode 310 in the radial direction of the catheter 100 is 0.05mm-0.3mm, and the width of the first electrode 310 in the axial direction of the catheter 100 is 1.5mm-12mm.

[0080] Further, in the third embodiment, the angle of the second electrode 320 in the circumferential direction of the catheter 100 is 45°-160°, the thickness of the second electrode 320 in the radial direction of the catheter 100 is 0.05mm-0.3mm, and the width of the second electrode 320 in the axial direction of the catheter 100 is 1.5mm-12mm.

[0081] See also Fig.13 and Fig.14 In the fourth embodiment, the first electrode 310 and the second electrode 320 are both flexible electrodes, and the first electrode 310 and the second electrode 320 are both spirally shaped and staggeredly coiled on the outer peripheral surface of the distal end of the catheter 100. Such a structural design makes the electric field more evenly distributed in the target tissue, which helps to improve the uniformity and thoroughness of ablation. The effective ablation range can be maintained even at low voltage, and the spiral structure can always ablate the surrounding tissue, and the ablation range also increases with the increase of voltage.

[0082] It should be noted that the present application performs comsol verification on the arrangement forms of the electrode assembly 300 of the first embodiment, the second embodiment, the third embodiment and the fourth embodiment respectively, referring to Figure 8 , Fig.10 , Fig.12 and Fig.14 Comsol images show that under the high voltage of 2000V, the ablation effects of the electrode arrangements in different embodiments are all excellent. It is judged that the above electrode arrangements are acceptable. Fig.15 and Fig.16As shown, the first and fourth embodiments are further explored and verified by Comsol at low voltage (below 800V). Experiments are carried out in Comsol at 100V~600V in sequence. The traditional electrode arrangement of the first embodiment is verified to be unable to achieve effective ablation. Ablation can only be achieved between the two electrodes as the voltage gradually increases. The new electrode arrangement scheme - the fourth embodiment, can maintain an effective ablation range even at low voltage. The spiral structure can always ablate the surrounding tissues, and the ablation range also increases with the increase of voltage. It has a better ablation effect than the electrode arrangement scheme of the first embodiment.

[0083] It should be emphasized that the present application does not specifically limit the number of electrode assemblies 300, and the number and arrangement of electrode assemblies 300 can be flexibly adjusted according to actual needs. Fig.12 In the third embodiment shown, the number of electrode assemblies 300 is set to two, and the two groups of electrode assemblies 300 are spaced apart and distributed along the axial direction of the catheter 100. Similarly, the first embodiment, the second embodiment, the fourth embodiment or other embodiments not shown may also be implemented in this way, and the number is not limited to two, but may also be three, four or more.

[0084] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0085] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

[0086] In the description of the present invention, it should be understood that the terms "axial", "radial", "circumferential", "length", "width", "thickness", "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0087] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0088] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0089] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0090] It should be noted that when an element is referred to as being "located on", "fixed on" or "set on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and do not represent the only implementation method.

[0091] In the description of this specification, the description with reference to the terms "one embodiment", "other implementation methods", etc. means that the specific features, structures, materials or features described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

Claims

1. A pulse ablation device, characterized in that: include: catheter; A multi-lumen tube is disposed in the catheter, wherein a first line lumen, a second line lumen and a third line lumen are formed in the multi-lumen tube; A spring tube is arranged in the catheter and sleeved on the outer peripheral surface of the multi-lumen tube; A fixing seat, disposed at the distal end of the catheter, wherein the proximal end of the fixing seat is fixed to the distal end of the multi-lumen tube; An electrode head, disposed on a side of the fixing seat facing away from the multi-lumen tube and used for fixing to a target tissue; An electrode assembly, comprising a first electrode and a second electrode spaced apart from each other, wherein the first electrode and the second electrode are both disposed on an outer peripheral surface of the distal end of the catheter; A first wire is disposed in the first wire cavity and a distal end of the first wire is electrically connected to the first electrode; A second wire is disposed in the second wire cavity and a distal end of the second wire is electrically connected to the second electrode; A third wire is disposed in the third wire cavity and a distal end of the third wire is electrically connected to the electrode head; The first electrode and the second electrode are located between the fixing seat and the distal end of the spring tube, and the distal end of the spring tube is spaced apart from any one of the first electrode and the second electrode in the axial direction of the catheter, and any two of the electrode head, the first electrode and the second electrode can discharge simultaneously and have opposite electrical properties.

2. The pulse ablation device according to claim 1, characterized in that: The fixing seat includes a main body and a protruding portion connected to the main body, the protruding portion is arranged at the distal end of the main body, the electrode head fixing sleeve is arranged on the outer circumference of the protruding portion, and a receiving cavity is opened at the proximal end of the main body, and the receiving cavity is used to be fixed and connected with the distal end of the multi-lumen tube.

3. The pulse ablation device according to claim 1, characterized in that: The distal end of the third wire is passed through the fixing seat and is electrically connected to the electrode head; And / or, the electrode head is spiral-shaped and can be rotated under the drive of the catheter to drill into and fix to the target tissue; And / or, the distal end of the multi-lumen tube is exposed from the spring tube to be connected to the fixing seat.

4. The pulse ablation device according to any one of claims 1 to 3, characterized in that: The first electrode and the second electrode are both ring-shaped and are sleeved on the outer peripheral surface of the distal end of the catheter. The first electrode and the second electrode are spaced apart in the axial direction of the catheter.

5. The pulse ablation device according to claim 4, characterized in that: The thickness of the first electrode in the radial direction of the catheter is 0.05 mm-0.3 mm; And / or, the width of the first electrode in the axial direction of the catheter is 0.75 mm-4.5 mm; And / or, the thickness of the second electrode in the radial direction of the catheter is 0.05 mm-0.3 mm; And / or, the width of the second electrode in the axial direction of the catheter is 0.75 mm-4.5 mm.

6. The pulse ablation device according to any one of claims 1 to 3, characterized in that: The first electrode and the second electrode are both in a tile shape and are arranged at intervals on the outer peripheral surface of the catheter along the circumference of the catheter.

7. The pulse ablation device according to claim 6, characterized in that: The first electrode and the second electrode are located at corresponding positions in the axial direction of the catheter.

8. The pulse ablation device according to claim 6, characterized in that: The positions of the first electrode and the second electrode in the axial direction of the catheter are at least partially staggered.

9. The pulse ablation device according to claim 6, characterized in that: The included angle of the first electrode in the circumferential direction of the catheter is 45° to 160°; And / or, the thickness of the first electrode in the radial direction of the catheter is 0.05 mm-0.3 mm; And / or, the width of the first electrode in the axial direction of the catheter is 1.5 mm-12 mm; And / or, the included angle of the second electrode in the circumferential direction of the catheter is 45° to 160°; And / or, the thickness of the second electrode in the radial direction of the catheter is 0.05 mm-0.3 mm; And / or, the width of the second electrode in the axial direction of the catheter is 1.5 mm-12 mm.

10. The pulse ablation device according to any one of claims 1 to 3, characterized in that: The first electrode and the second electrode are both spirally shaped and staggeredly coiled on the outer peripheral surface of the distal end of the catheter; And / or, both the first electrode and the second electrode are flexible electrodes.

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