Beautifying medicinal composition for improving skin care efficiency, application of beautifying medicinal composition and nursing beautifying medicinal composition

Abstract

The invention belongs to the technical field of beauty medicine, and provides a beauty medicinal composition for improving skin care efficiency, application of the beauty medicinal composition and a nursing and beauty medicinal composition. The beauty medicinal composition comprises the following components: an inorganic compound, hyaluronic acid and water for injection. The beauty medicinal composition is obtained by mixing the inorganic compound, hyaluronic acid and water for injection. The beauty medicinal composition provided by the invention is a liquid material which does not generate floccule precipitates influencing the appearance and the use effect after standing for enough long time, is completely suitable for hydro-optical needle injection, rolling needle injection and microcrystal injection, is introduced into deep cells of human skin, and has the effects of skin care, whitening, wrinkle removal and the like. Metal oxide can also be added into the composition to prepare a pharmaceutical composition with a sunscreen function.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetic medicine, in particular to a cosmetic medicinal composition for skin care and a sunscreen cosmetic medicinal composition. Background Art

[0002] With the progress of social civilization, people have further demands for various skin care methods and the skin care materials used. At present, there are many kinds of skin care methods and corresponding skin care materials popular in the industry, each with its own strengths, but each also has its own defects. Considering the part of the human skin surface called the stratum corneum, while protecting the epidermis, it also hinders the skin care materials from penetrating into the deep cells for nutrition and repair. It is usually difficult to penetrate the stratum corneum by applying the paste; with the help of instruments introduced into the subcutaneous layer, such as the application form of water light needle, the skin care materials can better penetrate the stratum corneum and reach the deep cells for care.

[0003] At present, the injection materials used for skin care using microneedles are basically various types of collagen, protein, and natural extracts, including hyaluronic acid (medically known as sodium hyaluronate https: / / lemon.baidu.com / ec / video?id=sv_8341318132502702438), each of which has its own skin care effect. After multiple screenings, researchers in the industry noticed a substance called sodium calcium phosphosilicate (Actimins), which is composed of SiO 2 , Na 2 O, CaO and P 2 O 5 It is composed of basic ingredients such as sodium calcium phosphosilicate, calcium phosphate and calcium phosphate. It has the function of repairing, replacing and regenerating human tissues and forming bonds between various materials in tissues. If this material is introduced into the deep cells of human skin, it will act on the deep cells and have the effects of skin care, whitening and wrinkle removal. However, since sodium calcium phosphosilicate is in powder form, it is easy to produce flocculent precipitation that affects the appearance and use when mixed with water. Therefore, sodium calcium phosphosilicate is often used in creams and facial masks to play its role. Therefore, there is no mature theoretical research to prepare sodium calcium phosphosilicate into a cosmetic and medicinal composition that can be introduced into the subcutaneous tissue with the help of an instrument.

[0004] Prior art: A silicon-calcium-phosphorus-based bioactive material with antibacterial properties and a preparation method thereof, publication number CN113813447 A. The disclosed bioactive material precursor gel is formed by washing, drying, and then sintering at high temperature. The precursor gel is prepared from a silicon source, a calcium source, a phosphorus source, a strontium source, a zinc source, a template, a catalyst, ethanol, and deionized water. The application of the bioactive material in a microneedle injection solution can only achieve a concentration of one ten-thousandth of the bioactive material. If the concentration of the bioactive material is increased, the effect of clarifying the solution cannot be achieved, and flocs will be generated in the solution; and if the concentration of the bioactive material is further increased, a gel will be formed. At this time, it can only be applied to the affected area by other means, and the technical level of direct microneedle injection to deep cells for care cannot be achieved.

[0005] Therefore, how to prepare a cosmetic and medicinal composition using sodium calcium phosphosilicate based on the above-mentioned prior art has become a problem that those skilled in the art need to solve urgently. Summary of the invention

[0006] In view of this, the present invention provides a cosmetic and medicinal composition for improving skin care efficacy, its application and a care cosmetic and medicinal composition. The purpose is to solve the technical problem that sodium calcium phosphosilicate is difficult to prepare into a higher quality cosmetic and medicinal composition that can be introduced subcutaneously with the aid of an instrument.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] The present invention provides a cosmetic medicinal composition for improving skin care efficacy, comprising the following components:

[0009] Inorganic compounds, hyaluronic acid and water for injection;

[0010] The inorganic compound includes at least two of a calcium source, a phosphorus source, a silicon source, and a sodium source.

[0011] Furthermore, in parts by weight, the amount of the inorganic compound is 0.1 to 20 parts, the amount of hyaluronic acid is 10 to 200 parts, and the amount of water for injection is 10,000 parts.

[0012] Furthermore, in parts by weight, the amount of the inorganic compound is 0.5 to 16 parts, the amount of hyaluronic acid is 20 to 180 parts, and the amount of water for injection is 10,000 parts.

[0013] Furthermore, in parts by weight, the amount of the inorganic compound is 1 to 13 parts, the amount of hyaluronic acid is 40 to 150 parts, and the amount of water for injection is 10,000 parts.

[0014] Furthermore, in parts by weight, the amount of the inorganic compound is 3 parts, the amount of hyaluronic acid is 50-120 parts, and the amount of water for injection is 10,000 parts.

[0015] Furthermore, the calcium source comprises one or more of calcium oxide, calcium oxalate and calcium nitrate; the phosphorus source comprises phosphoric acid or triethyl phosphate; the silicon source comprises silicon dioxide or tetraethyl orthosilicate; and the sodium source comprises sodium oxide or sodium nitrate.

[0016] The present invention provides application of a cosmetic medicinal composition in a microneedle injection.

[0017] The present invention provides a skin care cosmetic medicinal composition, comprising a metal oxide and the above-mentioned cosmetic medicinal composition for skin care.

[0018] Furthermore, the particle size of the metal oxide is 0.05 to 500 μm; the metal oxide includes zirconium oxide, magnesium oxide or zinc oxide.

[0019] Furthermore, the amount of the metal oxide is 1 to 30% by weight of the cosmetic and medicinal composition.

[0020] It can be seen from the above technical solution that compared with the prior art, the beneficial effects of the present invention are as follows:

[0021] Since sodium calcium phosphosilicate is in powder form, it is easy to produce flocculent precipitation when mixed with water. After the pharmaceutical composition of sodium calcium phosphosilicate containing flocculent precipitation is introduced into the deep cells of human skin, the distribution of the drug caused by the flocculent is uneven, and its medical beauty effect will definitely be affected. In addition, the pharmaceutical composition of sodium calcium phosphosilicate containing flocculent precipitation has a poor appearance, which leads to the fact that those who need medical beauty cannot use products containing flocculent precipitation with confidence; and the present invention mixes the basic components of sodium calcium phosphosilicate with hyaluronic acid and water for injection. Without adding any other auxiliary agents, a liquid material without flocculent precipitation that affects the appearance and use effect can be obtained. The liquid material can be directly used by means of instruments such as water light needle injection, microcrystalline injection, rolling needle injection, etc., or it can be mixed with nutrients such as collagen, polypeptides or anti-inflammatory drugs to form a concentrated solution, which can be used by spraying or applying through simple component adjustment. The technical solution of the present invention is not only low in cost and simple in method, but also further expands and exerts the skin care, whitening and wrinkle removal functions of sodium calcium phosphosilicate. In addition, metal oxides such as zinc oxide and zirconium oxide can be added to the pharmaceutical composition to prepare a sunscreen beauty pharmaceutical composition, which provides a new approach for the application of sodium calcium phosphosilicate in cosmetic medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a picture of the cosmetic and medicinal composition prepared in Example 4;

[0023] Figure 2 This is a comparison chart of the cosmetic and medicinal composition prepared in Example 4 and the cosmetic and medicinal composition prepared in Comparative Example 1, wherein the left bottle is Comparative Example 1 and the right bottle is Example 4. DETAILED DESCRIPTION

[0024] The present invention provides a cosmetic medicinal composition for improving skin care efficacy, comprising the following components:

[0025] Inorganic compounds, hyaluronic acid and water for injection;

[0026] The inorganic compound includes at least two of a calcium source, a phosphorus source, a silicon source, and a sodium source.

[0027] In the present invention, the components in the inorganic compound may be mixed in any ratio.

[0028] In the present invention, the amount of the inorganic compound is 0.1 to 20 parts by weight, the amount of hyaluronic acid is 10 to 200 parts by weight, and the amount of water for injection is 10,000 parts by weight.

[0029] In the present invention, the amount of the inorganic compound is 0.5 to 16 parts by weight, the amount of hyaluronic acid is 20 to 180 parts by weight, and the amount of water for injection is 10,000 parts by weight.

[0030] In the present invention, the amount of the inorganic compound is 1 to 13 parts by weight, the amount of hyaluronic acid is 40 to 150 parts by weight, and the amount of water for injection is 10,000 parts by weight.

[0031] In the present invention, in parts by weight, the amount of the inorganic compound is 3 parts, the amount of hyaluronic acid is 50-120 parts, and the amount of water for injection is 10,000 parts.

[0032] In the present invention, the calcium source comprises one or more of calcium oxide, calcium oxalate and calcium nitrate, preferably calcium oxide; the phosphorus source comprises phosphoric acid or triethyl phosphate, preferably phosphoric acid; the silicon source comprises silicon dioxide or ethyl orthosilicate, preferably silicon dioxide; the sodium source comprises sodium oxide or sodium nitrate, preferably sodium oxide, wherein SiO 2 , CaO and Na 2 The particle size of O is ≤120 nm, preferably ≤110 nm, and more preferably ≤100 nm.

[0033] The present invention provides an application of a cosmetic medicinal composition in a microneedle injection. The cosmetic medicinal composition is introduced into the subcutaneous tissue by a water light needle injection, a roller needle injection or a microcrystal injection.

[0034] In the present invention, the inorganic compound, hyaluronic acid and water for injection are mixed to obtain the cosmetic and medicinal composition.

[0035] In the present invention, the mixing method includes any one of stirring with a magnetic stirrer, stirring with a mechanical stirrer, oscillating dispersion, homogenizing with a homogenizer, and microwave oscillation.

[0036] The present invention provides a skin care cosmetic medicinal composition, comprising a metal oxide and the above-mentioned cosmetic medicinal composition for skin care.

[0037] In the present invention, the particle size of the metal oxide is 0.05 to 500 μm, preferably 0.5 to 300 μm, and more preferably 1 to 100 μm; the metal oxide includes zirconium oxide, magnesium oxide or zinc oxide, preferably zirconium oxide or zinc oxide, and more preferably zirconium oxide.

[0038] In the present invention, the amount of the metal oxide is 1 to 30% by weight of the cosmetic and medicinal composition, preferably 3 to 25%, and more preferably 5 to 20%.

[0039] In the present invention, the metal oxide and the cosmetic medicinal composition are mixed to obtain the care cosmetic medicinal composition, and the care cosmetic medicinal composition is used to eliminate eczema, pregnancy spots, and diabetic ulcers.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] In terms of weight, take 20 parts of inorganic compound (4 parts of SiO 2 , 5 parts CaO, 4 parts Na 2 O and 7 parts H 3 PO 4 ), 200 parts of hyaluronic acid and 10,000 parts of water for injection are stirred and mixed evenly with a mechanical stirrer to obtain a colorless and odorless liquid cosmetic medicinal composition, which is sterilized and put into a syringe for use.

[0043] Example 2

[0044] In terms of weight, 0.5 parts of inorganic compound (0.1 parts of SiO 2 , 0.3 parts CaO and 0.1 parts H 3 PO 4 ), 20 parts of hyaluronic acid and 10,000 parts of water for injection are stirred and mixed evenly with a mechanical stirrer to obtain a colorless and odorless liquid cosmetic medicinal composition, which is sterilized and put into a syringe for use.

[0045] Example 3

[0046] In terms of weight, 13 parts of inorganic compounds (4 parts of CaO, 4 parts of Na 2 O and 5 parts H 3 PO 4 ), 150 parts of hyaluronic acid and 10,000 parts of water for injection are stirred and mixed evenly with a magnetic stirrer to obtain a colorless and odorless liquid cosmetic medicinal composition, which is sterilized and put into a syringe for use.

[0047] Example 4

[0048] In terms of weight, take 3 parts of inorganic compound (0.5 parts of SiO 2 , 1 part CaO, 0.5 part Na 2 O and 1 part H 3 PO 4 ), 100 parts of hyaluronic acid and 10,000 parts of water for injection are mixed evenly by shaking and dispersing to obtain a colorless and odorless liquid cosmetic medicinal composition, which is then sterilized and put into a syringe for later use.

[0049] Figure 1 This is a picture of the cosmetic medicinal composition prepared in this example. Figure 1 The cosmetic and medicinal composition is a colorless and transparent solution.

[0050] Example 5

[0051] In terms of weight, take 8 parts of inorganic compounds (3 parts of CaO, 1 part of Na 2 O and 4 parts H 3 PO 4 ), 80 parts of hyaluronic acid and 10,000 parts of water for injection are mixed in a homogenous manner to obtain a colorless and odorless liquid cosmetic medicinal composition, which is sterilized and put into a syringe for use.

[0052] Comparative Example 1

[0053] In terms of weight, take 22 parts of inorganic compound (4 parts of SiO 2 , 5 parts CaO, 6 parts Na 2 O and 7 parts H 3 PO 4 ), 220 parts of hyaluronic acid and 10,000 parts of water for injection are stirred and mixed evenly with a mechanical stirrer to obtain a cosmetic medicinal composition, which is then sterilized and put into a syringe for later use.

[0054] Figure 2 The figure is a comparison diagram of the cosmetic and medicinal composition prepared in Example 4 and the cosmetic and medicinal composition prepared in Comparative Example 1, wherein the left bottle is Comparative Example 1 and the right bottle is Example 4. It can be clearly observed from the red frame in the left bottle that the cosmetic and medicinal composition prepared in Comparative Example 1 has the following characteristics: Figure 2The flocculent suspended matter is pointed by the red arrow in the middle red frame.

[0055] The physical and chemical indicators of the cosmetic and medicinal compositions prepared in Examples 1 to 5 and Comparative Example 1 are shown in Table 1.

[0056] Table 1 Physical and chemical indicators of the cosmetic medicinal compositions prepared in Examples 1 to 5 and Comparative Example 1

[0057] project Lead (mg / kg) Arsenic (mg / kg) Mercury (mg / kg) Cadmium (mg / kg) pH(25℃) Example 1 3.24 1.36 0.47 2.62 8.2 Example 2 1.89 0.72 0.09 1.43 7.5 Example 3 2.75 1.29 0.39 2.19 7.9 Example 4 1.27 0.58 0.05 1.16 7.2 Example 5 2.96 1.14 0.25 2.33 8.0 Comparative Example 1 3.36 1.38 0.61 2.74 8.7

[0058] The microbial indicators of the cosmetic and medicinal compositions prepared in Examples 1 to 5 and Comparative Example 1 are shown in Table 2.

[0059] Table 2 Microbiological indicators of the cosmetic and medicinal compositions prepared in Examples 1 to 5 and Comparative Example 1

[0060]

[0061] It can be seen from Table 1 and Table 2 that the safety performance of the cosmetic medicinal composition prepared by the present invention meets the testing standards of FDA.

[0062] The cosmetic medicinal compositions prepared in Examples 1 to 5 and Comparative Example 1 were placed in syringes and allowed to stand for 1 day, 7 days, 30 days and 90 days, and then the precipitation was observed. The precipitation results are shown in Table 3.

[0063] Table 3 Precipitation results of materials prepared in Examples 1 to 5 and Comparative Example 1

[0064] time 1 day 7 days 30 days 90 days Example 1 No flocculent precipitation No flocculent precipitation No flocculent precipitation No flocculent precipitation Example 2 No flocculent precipitation No flocculent precipitation No flocculent precipitation No flocculent precipitation Example 3 No flocculent precipitation No flocculent precipitation No flocculent precipitation No flocculent precipitation Example 4 No flocculent precipitation No flocculent precipitation No flocculent precipitation No flocculent precipitation Example 5 No flocculent precipitation No flocculent precipitation No flocculent precipitation No flocculent precipitation Comparative Example 1 No flocculent precipitation Micro-flocculation A small amount of flocculent precipitation A small amount of flocculent precipitation

[0065] It can be seen from Table 3 that within the dosage range of the present invention, the prepared cosmetic medicinal composition is a colorless and odorless liquid material, and no flocculent precipitation is generated after standing for 3 months, which meets the requirements for injection.

[0066] Example 4, Comparative Example 1, water and a commercially available product (Harmony CA) were subjected to fibroblast proliferation experiments respectively, with the same experimental conditions. The cell proliferation rates were calculated after 1 day and 3 days. The test results are shown in Table 4.

[0067] Table 4 Fibroblast proliferation test results

[0068]

[0069]

[0070] As shown in Table 4, the cosmetic and medicinal composition prepared by the present invention can promote the proliferation of fibroblasts, and the proliferation rate is comparable to that of commercially available products.

[0071] Example 4, comparative example 1, water and a commercially available product (Harmony CA) were respectively subjected to zebrafish tail fin repair experiments under completely identical experimental conditions. The relative growth multiples of the tail fin were calculated after 7 days. The test results are shown in Table 5.

[0072] Table 5 Results of zebrafish tail fin repair experiment

[0073]

[0074] As shown in Table 5, the cosmetic medicinal composition prepared by the present invention has a significant promoting effect on the zebrafish tail fin, and its repair ability is no less than that of commercially available products, and has excellent tissue damage repair ability.

[0075] Example 6

[0076] Zirconium oxide was added to the cosmetic and medicinal composition prepared in Example 4, the amount of zirconium oxide being 4% of the mass of the cosmetic and medicinal composition, and the mixture was mixed evenly by shaking and dispersing to obtain a sunscreen cosmetic and medicinal composition.

[0077] Example 7

[0078] Zirconium oxide was added to the cosmetic and medicinal composition prepared in Example 4, the amount of zirconium oxide being 10% of the mass of the cosmetic and medicinal composition, and the mixture was mixed evenly by shaking and dispersing to obtain a sunscreen cosmetic and medicinal composition.

[0079] Example 8

[0080] Zinc oxide was added to the cosmetic and medicinal composition prepared in Example 4, the amount of zinc oxide being 4% of the mass of the cosmetic and medicinal composition, and the mixture was uniformly mixed by shaking and dispersing to obtain a sunscreen cosmetic and medicinal composition.

[0081] Example 9

[0082] Zirconium oxide was added to the cosmetic and medicinal composition prepared in Example 4, and the amount of magnesium oxide was 20% of the mass of the cosmetic and medicinal composition. The mixture was evenly mixed by shaking and dispersing to obtain a sunscreen cosmetic and medicinal composition.

[0083] The microbial indicators of the sunscreen cosmetic medicinal compositions prepared in Examples 6 to 9 are shown in Table 6.

[0084] Table 6 Microbiological indicators of the sunscreen cosmetic medicinal compositions prepared in Examples 6 to 9

[0085]

[0086]

[0087] It can be seen from Table 6 that the total bacterial count in the sunscreen cosmetic medicinal composition prepared by the present invention does not exceed 1000 cfu / g, and the total count of molds and yeasts does not exceed 100 cfu / g, which meets the product requirements of cosmetic hygiene regulations.

[0088] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A cosmetic medicinal composition for improving skin care efficacy, It is characterized in that Includes the following components: Inorganic compounds, hyaluronic acid and water for injection; The inorganic compound includes at least two of a calcium source, a phosphorus source, a silicon source, and a sodium source.

2. The cosmetic and medicinal composition according to claim 1, It is characterized in that In parts by weight, the amount of the inorganic compound is 0.1 to 20 parts, the amount of hyaluronic acid is 10 to 200 parts, and the amount of water for injection is 10,000 parts.

3. The cosmetic and medicinal composition according to claim 1, It is characterized in that In parts by weight, the amount of the inorganic compound is 0.5 to 16 parts, the amount of hyaluronic acid is 20 to 180 parts, and the amount of water for injection is 10,000 parts.

4. The cosmetic and medicinal composition according to claim 1, It is characterized in that In terms of weight, the amount of the inorganic compound is 1 to 13 parts, the amount of hyaluronic acid is 40 to 150 parts, and the amount of water for injection is 10,000 parts.

5. The cosmetic and medicinal composition according to claim 1, It is characterized in that In terms of weight, the amount of the inorganic compound is 3 parts, the amount of hyaluronic acid is 60-100 parts, and the amount of water for injection is 10,000 parts.

6. The cosmetic and medicinal composition according to claim 1, It is characterized in that The calcium source comprises one or more of calcium oxide, calcium oxalate and calcium nitrate; the phosphorus source comprises phosphoric acid or triethyl phosphate; the silicon source comprises silicon dioxide or ethyl orthosilicate; and the sodium source comprises sodium oxide or sodium nitrate.

7. Use of the cosmetic and medicinal composition according to any one of claims 2 to 5 in microneedle injection.

8. A cosmetic medicine composition, It is characterized in that The present invention comprises a metal oxide and the cosmetic and medicinal composition for skin care according to claim 1.

9. The cosmetic care medicinal composition according to claim 8, It is characterized in that The particle size of the metal oxide is 0.05-500 μm; the metal oxide includes zirconium oxide, magnesium oxide or zinc oxide.

10. The cosmetic care medicinal composition according to claim 9, It is characterized in that The amount of the metal oxide used is 1 to 30% of the mass of the cosmetic and medicinal composition.

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