Oral ulcer treatment film agent containing pericarpium citri reticulatae extract and preparation method of oral ulcer treatment film agent

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a film agent acting on oral ulcer, which comprises the effective component of pericarpium citri reticulatae extract. The invention also provides a preparation method of the film agent for treating oral ulcer. According to the medicine and the film agent acting on the oral ulcer, traditional Chinese medicine pericarpium citri reticulatae is adopted as a raw material, extracted, concentrated, dried, smashed and sieved through a 100-mesh sieve for standby application. Taking ethyl cellulose as a backing isolation layer, mixing the obtained fine powder with a film forming material (chitosan, sodium alginate and polyvinyl alcohol) solution and glycerol, coating, drying, dividing, applying a protective film, and packaging. The clinical application of the oral ulcer film agent can effectively relieve pain of oral ulcer patients, promote healing of ulcer surfaces and shorten the canker course.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a film for treating oral ulcers and a preparation method thereof. The film takes Chinese medicine tangerine peel as a main active ingredient and is prepared through a specific extraction and preparation process, aiming to effectively relieve the symptoms of oral ulcers and promote the healing of ulcer surfaces. Background Art

[0002] Oral ulcers are common oral mucosal diseases, and patients are often accompanied by severe pain, which affects eating and daily life. Existing treatment methods mostly rely on local medication, but there are problems such as short drug residence time, easy erosion by saliva, and inconvenience for patients. Therefore, it is particularly important to develop a drug for the treatment of oral ulcers that has a long-lasting effect, is easy to use, and has significant efficacy. Summary of the invention

[0003] Objective: The purpose of the present invention is to provide a film for treating oral ulcers with tangerine peel extract as the main active ingredient, which can not only effectively relieve the pain of patients with oral ulcers, but also promote rapid healing of the ulcer surface and shorten the course of the disease, while providing a simple and efficient preparation method.

[0004] Technical solution: 1. Active ingredient: The active ingredient of the film of the present invention is tangerine peel extract, which is obtained from tangerine peel by a specific process, is rich in multiple active ingredients, and has a significant therapeutic effect on oral ulcers. 2. Preparation method: Raw material processing: Tangerine peel is dried at a constant temperature of 60°C and then crushed into coarse powder. Extraction process: 75% ethanol is used as the extraction solvent, and 80°C reflux extraction is performed for 1.5 hours according to a solid-liquid ratio of 1:7, followed by 60°C reduced pressure concentration and drying, and the obtained extract is crushed through a 100 mesh sieve for standby use. Preparation of film-forming materials: Chitosan, sodium alginate, and polyvinyl alcohol are used as film-forming materials for the drug-carrying layer, respectively dispersed in an appropriate amount of water, mixed after being fully swollen, and the above-treated tangerine peel extract dry powder and an appropriate amount of glycerin are added as a moisturizer, mixed evenly, and then allowed to stand for defoaming. Film molding: The bubble-free mixed solution is evenly coated on a glass plate pre-coated with ethyl cellulose and dried, dried at 50°C for 12 hours, divided, applied with a protective layer, and packaged.

[0005] Description of the drawings: Figure 1 is a schematic diagram of the film for treating oral ulcers with tangerine peel extract of the present invention, which consists of three layers. The main function of the protective layer is to protect the drug-carrying layer of the film, and its material is PET film; the main function of the drug-carrying layer is adhesion, drug loading and drug release, and it is composed of chitosan, sodium alginate, polyvinyl alcohol, three film-forming materials and tangerine peel extract. The function of the backing isolation layer is to protect the drug-carrying layer from saliva erosion, and its component is ethyl cellulose. When using, peel off the protective layer, align the drug-carrying layer with the ulcer site and apply it.

[0006] Beneficial effects: One-way release and long-lasting effect: The existence of the isolation layer effectively ensures the one-way release of the drug, reduces the dissolution of the drug by saliva, and thus prolongs the drug's action time on the ulcer surface. Enhanced adhesion and sustained release effect: Sodium alginate improves the adhesion of the patch, ensuring that the patch fits tightly to the ulcer surface; polyvinyl alcohol forms a gel skeleton, further slowing down the release rate of the drug and achieving sustained and stable release of the drug. Significant therapeutic effect: Clinical applications have shown that the film can significantly reduce the patient's pain, promote rapid healing of the ulcer surface, shorten the course of the disease, and improve the patient's quality of life.

Claims

1. A film for treating oral ulcers containing tangerine peel extract, characterized in that The active ingredient is tangerine peel extract, and the film is composed of a backing isolation layer and a drug-carrying layer, wherein the drug-carrying layer contains chitosan, sodium alginate, polyvinyl alcohol and tangerine peel extract.

2. The preparation method of the film for treating oral ulcers according to claim 1, comprising the steps of raw material processing, extraction process, film-forming material preparation and film-forming, which are specifically as follows: Pure Chinese medicine tangerine peel is taken as raw material, dried at 60°C and crushed into coarse powder, 75% ethanol is used as extraction solvent, the material-liquid ratio is 1:7, reflux extraction is carried out at 80°C for 1.5 hours, and concentrated and dried under reduced pressure at 60°C, and crushed to 100 mesh for standby use. Ethyl cellulose is used as the backing isolation layer, chitosan, sodium alginate, and polyvinyl alcohol are used as the film-forming materials of the drug-carrying layer (3:4:2) and are respectively dispersed in an appropriate amount of water, and the three are mixed after being fully swollen, and the above-mentioned tangerine peel extract powder crushed to 100 mesh and an appropriate amount of glycerin are added, and glycerin is used as a moisturizer. After mixing evenly, it is allowed to stand for defoaming. The bubble-free mixed solution is applied on a glass plate pre-coated with an ethyl cellulose isolation layer and dried, dried at 50°C for 12 hours, divided, applied with a protective layer, and packaged. The existence of the isolation layer can effectively ensure the unidirectional release of the drug, improve the dissolution effect of saliva on it, and prolong the action time of the drug. Sodium alginate is used to improve the adhesion performance, and polyvinyl alcohol can form a gel skeleton to slow down the drug release rate.

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