Functional sports blasting bead

Abstract

The invention relates to a functional sports blast bead candy, which consists of a capsule shell and a content sealed in the capsule shell, and is characterized in that the capsule shell consists of the following components in parts by weight: 20-60 parts of gelatin, 15-60 parts of a plasticizer, 1-25 parts of a humidifying agent, 5-40 parts of water, and optional proper amounts of edible essence, a sweetening agent, a coloring agent and a thickening agent; the content is prepared from the following raw materials in parts by weight: 1-99 parts of active ingredients and 1-99 parts of auxiliary materials. The functional sports blast bead candy has the advantages of supplementing energy and being convenient to carry. The active component is a traditional Chinese medicine composition for resisting fatigue and is prepared from the following raw materials in parts by mass: 20 parts of astragalus membranaceus, 15 parts of rhizoma polygonati, 8 parts of cinnamon, 6 parts of uncaria and 6 parts of mint.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine composition for resisting fatigue, and functional sports bursting bead candy and a preparation method thereof, belonging to the technical field of bursting bead. Background Art

[0002] Exploding beads, also known as exploding eggs or magic beans, refer to beads with a flowable slurry inside that can be squeezed. When squeezed, the slurry flows out, giving a bursting taste. Currently, they are mainly used as milk tea additives. They are covered with a seaweed film and contain juice or pectin. They have various flavors such as mango, lychee, strawberry, chocolate, passion fruit, orange, and cantaloupe. There is also an exploding bead on the market, which is filled with concentrated aromas, such as concentrated mint aromas. It is usually filled in the filter of cigarettes. Users can squeeze the exploding bead to discharge the aroma and improve the taste of the cigarette. The exploding bead technology is a new technology that has emerged in recent years. Juice and the like are wrapped in a film with special technology. With a little squeezing, the exploding bead collapses and the juice inside flows out. The taste is unique and interesting, and it is impressive.

[0003] Functional sports bursting bead candies are an increasingly popular health food that combines a variety of functional ingredients and sports nutrients to help people maintain energy and health during exercise and daily life. These candies usually contain high energy, high protein and a variety of vitamins and minerals, which can help people enhance their body's endurance and resistance while satisfying their sweet tooth. There are many types of functional sports bursting bead candies on the market, including various flavors and formulas, suitable for people of different ages and sports needs. With people's attention to healthy eating and the popularity of fitness culture, the market prospects for functional sports bursting bead candies are broad.

[0004] Fatigue is a common phenomenon in the body mediated by a series of complex physiological and biochemical processes. Fatigue is defined as the weakening of the force that muscles can produce, making it unable to maintain the predetermined exercise intensity, that is, sports fatigue. The generation of sports fatigue is often accompanied by changes in energy substances, metabolites, hormone levels, cell metabolism regulatory enzymes and antioxidant system enzymes. The essential reason is that the homeostasis of the internal environment loses balance, causing discomfort in the body. Persistent fatigue or severe fatigue not only affects people's normal life, but also leads to endocrine disorders, decreased immunity, and even organic diseases, threatening physical health. In addition, ordinary people often feel tired. Therefore, the development of anti-fatigue products suitable for the general population is of great and far-reaching significance. The anti-sports fatigue functional foods on the market contain a variety of ingredients, which are mainly divided into two categories. One is the basic substances required for the body to exercise, such as sugars, amino acids, inorganic salts, etc.; the other is based on its molecular regulatory mechanism, which has the functions of increasing energy utilization, removing harmful metabolites (such as ROS), and relieving body fatigue, such as functional factors, such as carnosine, carnitine, caffeine, ginsenosides, etc.

[0005] In today's society, people's pace of life is constantly accelerating. The lack of energy makes people often feel tired, so people gradually focus on maintaining their best condition and physical fitness. This situation has opened up a market for energy supplement products, especially in the field of sports. Because people need to consume a lot of physical energy during exercise, they often have a greater demand for energy supplements. At present, many athletes are also keen to use energy supplement products to improve their physical fitness and metabolism. At present, the energy supplement products on the market are mainly energy drinks, and the more representative products are: Red Bull and Dongpeng Special Drink. For sports scenes, energy drinks always have the problem of large volume and inconvenience in carrying. Therefore, in addition to energy drinks, functional candies with energy supplements are gradually entering the range of choices for athletes. Although candy has always been regarded as a kind of snack food, it is now gradually being given more functional expectations and becoming a functional carrier. Therefore, in the future development of the candy industry, functionality is a very promising development direction. Although the market share of functional candies on the market is relatively small, it still cannot be ignored. With the continuous popularization and development of national fitness activities and the continuous expansion of the number of people exercising, it is urgent to solve the related needs of athletes for convenient carrying and effective results. The bursting beads are small and light, so they can solve the related problems well. For this reason, functional sports bursting beads candies with energy replenishment are facing huge development opportunities. Based on the above findings and analysis, the team developed functional sports bursting beads candies that are easy to eat, easy to carry, green and safe, and can replenish energy. Summary of the invention

[0006] The first object of the present invention is to provide a functional sports bursting bead candy.

[0007] The functional sports bursting bead candy can be used for resisting fatigue.

[0008] The anti-fatigue ability may specifically be an ability to resist sports fatigue.

[0009] The shell of the functional sports bursting bead candy is made of edible bone gelatin made from collagen extracted from cattle bones, which can be melted in the mouth and can replenish part of the energy needed after consumption. The functional sports bursting bead candy is committed to solving the problems caused by the sports scenes of functional products on the market. Compared with other functional products, it is easier to eat, smaller in size, and very convenient to carry. In addition, unlike the functional products on the market, the functional sports bursting bead candy does not produce excess packaging waste, which can reduce the environmental burden to a certain extent and conform to the mainstream value orientation of green consumption. Not only that, in terms of taste, combined with the characteristics of the current group's pursuit of diversified tastes, the functional sports bursting bead candy has been innovatively upgraded in taste. At present, it has launched a variety of trendy flavors that are popular among consumers, such as mint, peach, and rose flavors, which greatly meet the taste buds and taste experience of the audience. It not only adapts to more demanding consumer groups, but also helps the layout of the product in the mainstream market to a certain extent.

[0010] The functional sports bursting bead candy of the present invention is composed of a capsule skin and contents sealed in the capsule skin, and is characterized in that: the capsule skin is composed of the following ingredients in parts by weight: 20-60 parts of gelatin, 15-60 parts of plasticizer, 1-25 parts of humidifier, 5-40 parts of water, and optional appropriate amounts of edible flavors, sweeteners, colorants, and thickeners; the contents are composed of the following raw materials in parts by weight: 1-99 parts of active ingredients and 1-99 parts of auxiliary materials.

[0011] The functional sports bursting bead candy is characterized in that the gelatin is a gelatin or a mixture of multiple gelatins from plant gelatin or animals.

[0012] The functional sports bursting bead candy is characterized in that the gelatin is bovine bone gelatin.

[0013] The functional sports bursting bead candy is characterized in that the plasticizer is one or more of glycerol, anhydrous glucose, sucrose, sorbitol, xylitol, maltitol or mannitol.

[0014] The functional sports bursting bead candy is characterized in that the wetting agent is one or more of sodium alginate, carrageenan, agar, microcrystalline cellulose or water-soluble starch.

[0015] The functional sports bursting bead candy is characterized in that the edible flavor includes one or a combination of sweet orange flavor, cherry flavor, strawberry flavor, lime flavor, mint essential oil, edible apple flavor, edible mint flavor, edible orange flavor, edible pineapple flavor, edible lemon flavor, edible banana flavor, and menthol;

[0016] The sweetener is selected from a mixture of one or more of sucrose, mannitol, xylitol, sorbitol, trehalose, fructose, maltose, glucose, isomaltose, isomaltooligosaccharide, stevioside, sodium cyclamate, acesulfame potassium, sucralose, aspartame, and mogroside;

[0017] The colorant is a mixture of one or more of carmine, new red, amaranth, allura red, erythrosine, azorubin, lemon yellow, sunset yellow, riboflavin, cantharidin, carotene, chlorophyll, acid brilliant green BS, brilliant blue, patent blue V, anthocyanin, cocoa shell pigment, iron oxide, caramel color, carbon black, and brilliant black.

[0018] The functional sports bursting bead candy is characterized in that the active ingredients are one or more of red deer antler powder, taurine, tea polyphenols, epimedium water or / and ethanol extract, ginseng water or / and ethanol extract.

[0019] The functional sports bursting bead candy, the content auxiliary material is one or more of a diluent, a suspending agent, and an emulsifier. The content auxiliary material is one or more of water, glycerol, polyethylene glycol, or Tween.

[0020] The active ingredient may be one or more of medium chain triglycerides, walnut oil, red deer antler powder, taurine, tea polyphenols, epimedium water or / and ethanol extract, ginseng water or / and ethanol extract, and the active ingredient may also be a traditional Chinese medicine extract.

[0021] The second object of the present invention is to provide a pharmaceutical composition with anti-fatigue effect, which is composed of the following raw materials in parts by weight: 20 parts of astragalus, 15 parts of polygonatum, 8 parts of cinnamon, 6 parts of Uncaria rhynchophylla and 6 parts of mint.

[0022] The traditional Chinese medicine composition is used for functional sports bursting bead candy.

[0023] Astragalus can strengthen the spleen and replenish the middle, raise yang and lift the sunken, while Polygonatum can replenish qi and nourish yin. It is combined with cinnamon bark which warms the interior, Uncaria rhynchophylla which calms the wind, and especially with mint which relieves exterior symptoms. The five Chinese medicines together can strengthen the spleen and kidney, replenish qi and calm the mind, promote the production of body fluids and nourish blood, strengthen the body to solve the root cause of fatigue, comprehensively replenish energy, improve the body's ability to resist free radical damage, and accelerate recovery from fatigue.

[0024] One of the purposes of the present invention is to provide a new use of the above-mentioned Chinese medicine composition in the field of medicine and health food, namely: the use of the Chinese medicine composition as an anti-fatigue ingredient in the preparation of a product that enhances the body's anti-fatigue ability.

[0025] The product can be medicine, food, health food, etc.

[0026] Astragalus is the root of Astragalus memeranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. of the genus Astragalus in the Leguminosae family. It has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, benefiting the defense and strengthening the exterior, promoting diuresis, and expelling toxins and promoting tissue regeneration.

[0027] Polygonatum sibiricum Delar.ex Redoute is a yin-tonifying medicine, which is the dried rhizome of Polygonatum sibiricum, Polygonatum sibiricum or Polygonatum sibiricum of the Liliaceae family. Polygonatum sibiricum has the effects of tonifying qi and nourishing yin, strengthening the spleen, moistening the lungs and benefiting the kidneys.

[0028] Cinnamon (Cinnamomum cassia (L.) D.Don) is the dry bark and branch bark of the cinnamon plant of the Lauraceae family. Cinnamon has the effects of warming the middle and tonifying the kidney, dispelling cold and relieving pain. It is mainly used to treat cold pain in the waist and knees, stomach pain due to deficiency and cold, chronic indigestion, abdominal pain, vomiting and diarrhea, and amenorrhea due to cold.

[0029] Uncariarhynchophylla (Miq.) Miq.ex Havil. is a vine of the genus Uncaria in the family Rubiaceae. It has the effects of clearing blood and calming the liver, calming wind and calming convulsions, and is used to treat wind-heat headaches, colds and convulsions, and convulsions.

[0030] Peppermint (Mentha canadensis Linnaeus), also known as silver dan grass and night scent, is a perennial herbaceous plant of the genus Mentha in the family Lamiaceae. It is used to treat colds, fever, sore throats, headaches, red and painful eyes, muscle pain, itchy skin urticaria, and measles. It is also effective for carbuncle, ulcer, scabies, ringworm, and lacquer sores. Peppermint contains menthol, which can freshen breath and has multiple medicinal properties. It can relieve abdominal pain and gallbladder problems such as cramps. It also has antiseptic and antibacterial effects, diuretic, expectorant, stomachic and digestive effects.

[0031] Meanwhile, the third object of the present invention is to provide a simple and convenient method for preparing a popping bead soft capsule. The method for preparing the functional sports popping bead candy is characterized by comprising the following steps:

[0032] (1) Preparation of glue:

[0033] ① Weigh purified water and plasticizer, mix them, heat to 45-90℃, then add gelatin while stirring to obtain substance a;

[0034] ② Dissolve the humidifier in purified water at room temperature and add it to the substance a obtained in step ①, and stir to obtain a mixed liquid;

[0035] ③ Pressurizing and heating the mixed liquid obtained in step ②, then degassing, cooling, and standing to obtain a glue solution;

[0036] (2) Preparation of contents:

[0037] First, mix the active ingredient with the excipients, then let it stand and evacuate until there are no bubbles, then pass it through a 60-120 mesh sieve and set aside;

[0038] (3) Suppression:

[0039] The glue liquid prepared in step (1) ③ flows onto the rubber wheel, and at the same time, the content prepared in step (2) is added to the hopper, the thickness of the rubber is adjusted, the temperature of the spray body is adjusted to 30-65°C, the pressure test of the capsule is carried out and the sealing of the rubber seam is checked. After confirmation, the content is filled, the filling amount is adjusted to the process requirements, and batch bead pressing is carried out;

[0040] (4) Drying:

[0041] The capsule shell pressed in step (3) is shaped for 1-3 hours, and then dried at 10-30° C. and 15-40% humidity to obtain a functional sports bursting bead candy.

[0042] The particle size of the explosive beads of the present invention can be selected to be 2.8-8 mm, preferably 6.0 mm. The thickness of the rubber can be selected to be 0.1-0.8 mm, preferably 0.2 mm.

[0043] Compared with the prior art, the present invention has the following beneficial effects:

[0044] The functional sports bursting bead candy of the present invention has the advantages of replenishing energy and being convenient to carry.

[0045] At the same time, the advantages of the present invention also lie in that the inventors have conducted a large number of studies on anti-fatigue substances and found that combining Astragalus, Polygonatum, Cinnamon, Uncaria and Peppermint in a suitable proportion can achieve better results. When the five components are compounded within a certain range, a good synergistic effect is achieved, which can significantly increase the weight-bearing swimming time of mice and achieve better anti-fatigue effects. The product of the present invention has clear ingredients, stable efficacy, small dosage, high safety, conforms to the principles of traditional Chinese medicine formulation, is formulated, and conventional excipients are appropriately added to prepare effective dosage forms suitable for human consumption, with a short cycle, and has been proven by animal experiments to have good anti-fatigue effects, meeting the product needs of modern consumers. DETAILED DESCRIPTION

[0046] The present invention will be further described below in conjunction with embodiments, but they do not limit the implementation of the present invention.

[0047] The contents described in the embodiments of this specification are merely enumerations of the implementation forms of the inventive concept. The protection scope of the present invention should not be deemed to be limited to the specific forms described in the embodiments. The protection scope of the present invention also extends to the equivalent technical means that can be thought of by those skilled in the art based on the inventive concept. Although the embodiments of the present invention are described below, the present invention is not limited to the above-mentioned specific embodiments and application fields. The following specific embodiments are merely illustrative and instructive, and not restrictive. Under the enlightenment of this specification and without departing from the scope of protection of the claims of the present invention, a person of ordinary skill in the art can also make a variety of forms, which all belong to the protection of the present invention.

[0048] Unless otherwise specified, the experimental methods used in the following examples are all conventional methods; the reagents, biological materials, etc. used in the following examples are all commercially available unless otherwise specified.

[0049] Example 1

[0050] A bursting bead candy consists of a capsule skin and contents sealed in the capsule skin, wherein the capsule skin consists of the following ingredients in parts by weight: 40 parts of gelatin, 10 parts of glycerol, 8 parts of sorbitol, 1 part of microcrystalline cellulose, and 20 parts of water; and the contents consists of the following raw materials in parts by weight: 10 parts of taurine, 9 parts of glycerol, and 80 parts of polyethylene glycol.

[0051] The gelatin is bovine bone gelatin.

[0052] The shape of the bursting beads is oval.

[0053] The preparation method of the above-mentioned bursting bead soft capsule comprises the following steps:

[0054] (1) Add 30 parts of purified water, 10 parts of glycerol and 8 parts of sorbitol into a glue tank, heat to 70°C, add 40 parts of bovine bone glue, and stir until completely dissolved; dissolve 1 part of microcrystalline cellulose with 10 parts of purified water at room temperature, add it into the glue tank, continue stirring and maintain the vacuum degree of -0.05Mpa, the temperature of 70°C, stir for 30 minutes, evacuate until there are no bubbles in the glue solution, and then put it into a glue storage barrel and keep it at 60°C for 1 hour;

[0055] (2) Mix 10 parts of taurine, 9 parts of glycerol, and 80 parts of polyethylene glycol, let stand for 30 minutes, evacuate until there are no bubbles, pass through an 80-mesh sieve, and set aside;

[0056] (3) Add the glue liquid in the glue storage barrel to the 60°C glue box of the soft capsule machine, spread the glue liquid evenly along the gap of the glue box on the drum to cool and form, adjust the thickness of the rubber skin to 0.4 mm, pour the content into the hopper of the soft capsule machine, maintain the spray body temperature at 45°C, perform a test pressure test on the capsules and check the joints of the rubber skin and the filling amount. After confirmation, press and check the filling amount of the soft capsules every 30 minutes;

[0057] (4) The compressed soft capsules are moved to a rotating cage via a conveyor belt for shaping, and then dried in a rotating cage at a temperature of 18° C. and a humidity of 22% for 14 hours until the water weight reaches 20 parts, thereby obtaining popping candies.

[0058] Example 2

[0059] A bursting pearl candy consists of a capsule skin and contents sealed in the capsule skin, wherein the capsule skin consists of the following ingredients in parts by weight: 20 parts of gelatin, 7 parts of glycerin, 8 parts of xylitol, 5 parts of water-soluble starch, 5 parts of microcrystalline cellulose, and 5 parts of purified water; the contents are made of the following raw materials in parts by weight: 20 parts of astragalus, 15 parts of polygonatum, 8 parts of cinnamon, 6 parts of uncaria, 6 parts of mint, and 80 parts of water.

[0060] The gelatin is derived from bovine bone gelatin.

[0061] The shape of the bursting beads is round.

[0062] The preparation method of the above-mentioned bursting bead soft capsule comprises the following steps:

[0063] (1) Add 15 parts of purified water, 7 parts of glycerol and 8 parts of sorbitol to a glue tank, heat to 45°C, add 19.5 parts of bovine bone glue, and stir until completely dissolved; dissolve 5 parts of microcrystalline cellulose and 5 parts of water-soluble starch with 1 part of purified water at room temperature, add to the glue tank, continue stirring and maintain the vacuum degree of 0.1Mpa, the temperature of 45°C, stir for 15 minutes, evacuate until there are no bubbles in the glue solution, and then put it into a glue storage barrel and keep it at 50°C for 2 hours;

[0064] (2) Mix the Chinese herbal medicine extracts evenly, let stand for 30 min, evacuate until there are no bubbles, and sieve through a 60-mesh sieve for later use;

[0065] (3) Add the glue liquid in the glue storage barrel to the 60°C glue box of the soft capsule machine, spread the glue liquid evenly along the gap of the glue box on the drum to cool and form, adjust the thickness of the rubber skin to 0.6 mm, pour the content into the hopper of the soft capsule machine, maintain the spray body temperature at 30°C, perform a test pressure test on the capsule and check the joints of the rubber skin and the filling amount. After confirmation, press and check the filling amount of the soft capsule every 30 minutes;

[0066] (4) The compressed soft capsules are moved to a rotating cage via a conveyor belt for shaping, and then dried in a rotating cage at a temperature of 23° C. and a humidity of 15% for 18 hours until the water content reaches 5 parts by weight, thereby obtaining popping candies.

[0067] Example 3

[0068] This embodiment provides a traditional Chinese medicine composition for relieving fatigue, which is composed of the following raw materials in parts by weight: 20 g of Astragalus, 15 g of Polygonatum, 8 g of Cinnamon, 6 g of Uncaria and 6 g of Menthus.

[0069] Extraction steps: weigh each raw material component according to the designed ratio, crush each weighed raw material, add 8 times the total weight of each raw material water and boil twice, each time for 2 hours, filter, concentrate the filtrate and set aside.

[0070] Example 4 Anti-fatigue test

[0071] In order to further verify the pharmacological effects of the explosive beads of the present invention, an animal efficacy experiment was carried out using the Chinese medicine composition of the present invention to verify its anti-fatigue effect.

[0072] Before administration, the dosage design is: the oral gavage volume for mice is 0.5 ml, and each mouse is calculated as 20 g, and the dosage (1 g of crude drug / kg) is controlled according to the amount of crude drug in the example or test group to achieve the above dosage.

[0073] The positive control drug is American ginseng capsules. Take about 2.0g of the contents of four capsules and add water to 20ml to obtain a 10% concentration of American ginseng capsule suspension. Store in a 4℃ refrigerator for less than 3 days.

[0074] Embodiment group: same as embodiment 3;

[0075] Experimental Group:

[0076] Experimental group 1: Astragalus 20g, Polygonatum 15g, Cinnamon 8g, Uncaria 6g.

[0077] Experimental group 2: Astragalus 20g, Polygonatum 15g, Cinnamon 8g, and Mint 6g.

[0078] Experimental group 3: Astragalus 20g, Polygonatum 15g, Uncaria 6g, and Mentha 6g.

[0079] Experimental group 4: Astragalus 20g, Polygonatum 15g, Cinnamon 8g, Uncaria 6g and Mentha 10g.

[0080] Experimental group 5: Astragalus 20g, Polygonatum 15g, Cinnamon 8g, Uncaria 6g and Mentha 1g.

[0081] Experimental group 6: Astragalus 20g, Polygonatum 15g, Cinnamon bark 8g, Uncaria rhynchophylla 6g and Mentha 20g.

[0082] Positive control group: American ginseng capsule. National medicine standard Z20027557, manufacturer: Guangzhou Daguang Pharmaceutical Co., Ltd. 0.5g / capsule, 3 capsules each time, 2 times a day.

[0083] Blank group: solvent 10ml / kg solvent water

[0084] Experimental methods

[0085] 1. Mouse weighted swimming test method

[0086] Experimental animals: 90 C57BL / 6J mice, male, SPF grade, 20-22 g.

[0087] Take 90 mice, adapt to the environment for 3 days, and screen by swimming. Divide them into nine groups every other day, 10 mice in each group, the first group is the vehicle control group, the second group is the positive control drug, the third, fourth, fifth, sixth, seventh, eighth, and ninth groups are respectively Example 3 group and test groups 1-6, 1g / kg. Give the test sample by gavage once a day for 15 consecutive days. Weigh the body weight twice a week and adjust the dosage in time. 30min after the last administration of the test sample, load the base of the mouse tail with a lead wire of 5% of the body weight and place it in a swimming box (500*500*400cm) to swim. The water depth is 30cm and the water temperature is 25℃±1.0℃. Record the time from the mouse being put into the water to sinking to the bottom of the water and then unable to float up, as the weight-bearing swimming time of the mouse.

[0088] The experimental results are shown in Table 1:

[0089] Table 1. Effect of weight-bearing swimming time on mice (n=10)

[0090] Group Dosage (g / kg) Weighted swimming time (min) Blank group 0 8.23±2.54 American Ginseng Capsules 1.0 12.46±2.10 Example 3 1.0 20.36±3.22 Experimental Group 1 1.0 12.26±1.08 Experimental Group 2 1.0 15.43±2.03 Experimental Group 3 1.0 14.65±2.08 Experimental Group 4 1.0 18.72±3.21 Experimental Group 5 1.0 17.46±1.76 Experimental Group 6 1.0 17.47±2.65

[0091] The results show that when Astragalus, Polygonatum, Cinnamon, Uncaria and Mentha are combined in the appropriate ratio of the present invention, a better effect can be achieved. When the five components are compounded within a certain range, a good synergistic effect is achieved, and the effect is significantly better than other ratios.

[0092] Example 5: Effect of the Chinese medicine composition of Example 3 on blood biochemical indices of mice with lipopolysaccharide-induced fatigue

[0093] Experimental animals: 40 C57BL / 6J mice, male, SPF grade, 20-22 g.

[0094] Test sample and dissolution: Same as Example 4.

[0095] Experimental instrument: small animal blood biochemical analyzer.

[0096] Experimental method: The mice were adaptively raised for 3-5 days after purchase, and randomly divided into solvent group, lipopolysaccharide LPS fatigue model group, positive drug group (American ginseng), and group of Example 3 according to body weight, with 10 mice in each group. Each group of mice underwent treadmill training 3 times according to the procedure (the speed was trained from 2m / s to 14m / s), and unqualified mice were eliminated. Except for the solvent control group, each group was intraperitoneally injected with LPS (0.2mg / kg) for 12h, and then treadmill exercise was performed to exhaustion 0.5h after a single gavage, and then the head was immediately cut off to collect blood. After the whole blood was rested at 4℃ for 4h, it was centrifuged at 3000r for 20min to obtain the supernatant to obtain a serum sample, and lactic acid (LAC) was tested on a biochemical analyzer. The reduction of lactic acid is considered to have an anti-fatigue effect.

[0097] The experimental results showed that compared with the solvent control group, LPS could significantly increase blood lactate (p<0.05), indicating that the model was successful; a single daily administration of 1 g / kg of Example 3 for 10 consecutive days could significantly reduce blood lactate (p<0.05), indicating that the anti-fatigue effect of the above-mentioned Chinese medicine composition in the LPS-induced pathological fatigue model may be exerted by regulating lactate.

Claims

1. A Chinese medicine composition for anti-fatigue, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by mass: 20 parts of astragalus, 15 parts of polygonatum, 8 parts of cinnamon, 6 parts of uncaria and 6 parts of mint. The Chinese medicine composition is used for functional sports bursting bead candy.

2. A functional sports bead candy, comprising a capsule skin and contents sealed in the capsule skin, characterized in that: The capsule skin is composed of the following ingredients in parts by weight: 20-60 parts of gelatin, 15-60 parts of plasticizer, 1-25 parts of humidifier, 5-40 parts of water, and optional appropriate amounts of edible flavors, sweeteners, colorants, and thickeners; the content is composed of the following raw materials in parts by weight: 1-99 parts of active ingredients and 1-99 parts of auxiliary materials.

3. The functional sports bursting bead candy according to claim 2, characterized in that: The gelatin is one gelatin or a mixture of multiple gelatins from plant gelatin or animal.

4. The functional sports bursting bead candy according to claim 3, characterized in that: The gelatin is bovine bone glue.

5. The functional sports bursting bead candy according to claim 2, characterized in that: The plasticizer is one or more of glycerol, anhydrous glucose, sucrose, sorbitol, xylitol, maltitol or mannitol.

6. The functional sports bursting bead candy according to claim 2, characterized in that: The humidifier is one or more of sodium alginate, carrageenan, agar, microcrystalline cellulose, acetate starch or water-soluble starch.

7. The functional sports bursting bead candy according to claim 2, characterized in that: The edible flavors include one or a combination of sweet orange flavor, cherry flavor, strawberry flavor, lime flavor, mint essential oil, edible apple flavor, edible mint flavor, edible orange flavor, edible pineapple flavor, edible lemon flavor, edible banana flavor, and menthol; The sweetener is selected from a mixture of one or more of sucrose, mannitol, xylitol, sorbitol, trehalose, fructose, maltose, glucose, isomaltose, isomaltooligosaccharide, stevioside, sodium cyclamate, acesulfame potassium, sucralose, aspartame, and mogroside; The colorant is a mixture of one or more of carmine, new red, amaranth, allura red, erythrosine, azorubin, lemon yellow, sunset yellow, riboflavin, cantharidin, carotene, chlorophyll, acid brilliant green BS, brilliant blue, patent blue V, anthocyanin, cocoa shell pigment, iron oxide, caramel color, carbon black, and brilliant black.

8. The functional sports bursting bead candy according to claim 2, characterized in that: The active ingredient is one or more of medium chain triglycerides, walnut oil, red deer antler powder, taurine, tea polyphenols, epimedium water or / and ethanol extract, ginseng water or / and ethanol extract, and the active ingredient can also be a traditional Chinese medicine extract.

9. The functional sports bursting bead candy according to claim 2, characterized in that: The active ingredient is prepared from a traditional Chinese medicine composition consisting of the following raw materials in parts by weight: 20 parts of astragalus, 15 parts of polygonatum, 8 parts of cinnamon, 6 parts of uncaria and 6 parts of mint.

10. The functional sports bursting bead candy according to claim 2, characterized in that: The content auxiliary materials are one or more of diluents, suspending agents, and emulsifiers.

11. The functional sports bursting bead candy according to claim 10, characterized in that: The content auxiliary materials are one or more of water, glycerol, polyethylene glycol or Tween.

12. A method for preparing the functional sports bursting bead candy according to any one of claims 2 to 11, characterized in that The following steps are involved: (1) Preparation of glue: ① Weigh purified water and plasticizer, mix them, heat to 45-90℃, then add gelatin while stirring to obtain substance a; ② Dissolve the humidifier in purified water at room temperature and add it to the substance a obtained in step ①, and stir to obtain a mixed liquid; ③ Pressurizing and heating the mixed liquid obtained in step ②, then degassing, cooling, and standing to obtain a glue solution; (2) Preparation of contents: First, mix the active ingredient with the excipients, then let it stand and evacuate until there are no bubbles, then pass it through a 60-120 mesh sieve and set aside; (3) Suppression: The glue liquid prepared in step (1) ③ flows onto the rubber wheel, and at the same time, the content prepared in step (2) is added to the hopper, the thickness of the rubber is adjusted, the temperature of the spray body is adjusted to 30-65°C, the pressure test of the capsule is carried out and the sealing of the rubber seam is checked. After confirmation, the content is filled, the filling amount is adjusted to the process requirements, and batch bead pressing is carried out; (4) Drying: The capsule shell pressed in step (3) is shaped for 1-3 hours, and then dried at 10-30° C. and 15-40% humidity to obtain a functional sports bursting bead candy.