Traditional Chinese medicine composition for treating AIDS (Acquired Immune Deficiency Syndrome), consolidating basis and

Abstract

The traditional Chinese medicine composition for treating AIDS and consolidating basis is prepared from the following raw materials in parts by weight: 8-10 parts of raw radix astragali, 7-10 parts of American ginseng, 8-10 parts of poria cocos, 3-6 parts of lucid ganoderma, 4-6 parts of rhizoma atractylodis macrocephalae, 4-6 parts of rhodiola rosea, 8-10 parts of rhizoma atractylodis, 20-30 parts of semen coicis, 3-6 parts of cortex magnoliae officinalis, 7-9 parts of ginger processed pinellia, 4-6 parts of fructus tsaoko, 11-15 parts of rhizoma smilacis glabrae, 7-10 parts of radix salviae miltiorrhizae and 7-10 parts of polygala tenuifolia. According to the traditional Chinese medicine preparation and the preparation method thereof, the problems that the living quality of a patient is seriously affected and the immunity of the patient is low due to various adverse reactions, especially hepatotoxicity, in the existing treatment process can be solved.

Description

Technical Field

[0001] The present application relates to the technical field of AIDS traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating AIDS and restoring the body's constitution and a preparation method thereof. Background Art

[0002] Acquired Immune Deficiency Syndrome (AIDS) is an infectious disease caused by human immunodeficiency virus (HIV) infection and characterized by progressive immune dysfunction. The main treatment method currently used in clinic is Highly Active Anti-Retroviral Therapy (HAART), which uses a variety of antiretroviral drugs together to control the proliferation of the virus in the body, thereby restoring the body's immune function, reducing viral transmission, and delaying disease progression.

[0003] AIDS is a systemic syndrome caused by HIV infection. The level of CD4+T lymphocytes is an important indicator for evaluating the immune function and clinical efficacy of HIV-infected patients. Although HAART treatment can prolong the survival of patients, there are still many adverse reactions, especially liver toxicity, which seriously affects the quality of life of patients and weakens their immunity.

[0004] To this end, the present application provides a traditional Chinese medicine composition for treating AIDS and restoring the body's vitality, and a preparation method thereof, which can improve the patient's immune function and improve the patient's liver damage caused by HAART. Summary of the invention

[0005] The present application provides a traditional Chinese medicine composition for treating AIDS and restoring the body's constitution and a preparation method thereof, which can solve the problems of various adverse reactions of existing HAART treatment for AIDS patients, especially liver toxicity, which seriously affects the patients' quality of life and the patients' low immunity.

[0006] In order to solve the above technical problems, this application provides the following technical solutions:

[0007] A traditional Chinese medicine composition for treating AIDS and strengthening the body, comprising the following raw materials in parts by weight: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, and 7-10 parts of Polygala tenuifolia.

[0008] Furthermore, the Chinese medicine composition is composed of the following raw materials in parts by weight: 8 parts of raw astragalus, 7 parts of American ginseng, 8 parts of Poria, 3 parts of Ganoderma lucidum, 4 parts of Atractylodes macrocephala, 4 parts of Rhodiola rosea, 8 parts of Atractylodes lancea, 20 parts of Coix seeds, 3 parts of Magnolia officinalis, 7 parts of Pinellia ternata, 4 parts of Amomum villosum, 11 parts of Smilax glabra, 7 parts of Salvia miltiorrhiza, and 7 parts of Polygala tenuifolia.

[0009] Furthermore, the Chinese medicine composition is composed of the following raw materials in parts by weight: 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, and 10 parts of Polygala tenuifolia.

[0010] A method for preparing a traditional Chinese medicine composition for treating AIDS, comprising the following steps:

[0011] First, the following Chinese medicinal raw materials: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, 7-10 parts of Polygala tenuifolia are mixed in proportion, soaked in water for 3-4 hours, heated and decocted for 2-3 times, each time for 60 minutes, the decoctions are combined, and then allowed to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decoction to obtain a concentrated solution;

[0012] Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 60-80° C. to obtain a traditional Chinese medicine.

[0013] Further, the following steps are included:

[0014] First, the following Chinese medicinal raw materials: 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, 10 parts of Polygala tenuifolia are mixed in proportion, soaked in water for 4 hours, heated and decocted twice, each time for 60 minutes, the decoctions are combined, and decocted at 80°C, then allowed to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decocting, wherein the density ratio of water to filtrate is 1:1.32-1.35, to obtain a concentrated solution;

[0015] Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 80° C. to obtain a traditional Chinese medicine.

[0016] Furthermore, the amount of the soluble starch added to the concentrated solution is 10-12% of the added Chinese medicinal raw material.

[0017] Furthermore, the specific dosage form of the Chinese medicine is capsules.

[0018] Furthermore, the specific dosage form of the Chinese medicine is granules.

[0019] The beneficial effects of the present invention are as follows:

[0020] 1. The Chinese medicine composition provided by the present invention can prevent further expansion of skin lesions and gradually restore the skin lesions to normal skin color when treating AIDS. The formula is comprehensive and reasonable, and has no side effects, and is suitable for patients to take for long-term treatment.

[0021] 2. The Chinese medicine composition of the present invention has the effects of invigorating Qi and restoring vitality, detoxifying and strengthening the body. The Chinese medicine Aiqi Fuyuan Capsule combined with HAART to treat asymptomatic AIDS patients can reduce the liver function damage caused by HAART, improve the patient's immune function, and improve clinical related symptoms.

[0022] 3. The Chinese medicine composition provided by the present invention has stable efficacy, is safe and reliable, is easy to take, and has a good therapeutic effect. DETAILED DESCRIPTION

[0023] In order to enable those skilled in the art to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below. It is obvious that the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0024] AIDS is an infectious disease caused by human immunodeficiency virus infection. The main treatment method currently used in clinical practice is Highly Active Anti-Retroviral Therapy (HAART), which uses a variety of antiretroviral drugs together to control the proliferation of the virus in the body, thereby restoring the body's immune function, reducing viral transmission, and delaying disease progression. HAART treatment is the combination of three or more antiviral drugs to treat AIDS. HAART can prolong the patient's survival period, but there are still many adverse reactions, especially liver toxicity.

[0025] At present, the duration of the asymptomatic period of AIDS is about 6-8 years, or even longer. Therefore, it is particularly important to strengthen the body's immunity and delay the onset of AIDS in the early stage of HIV infection. Through effective drug intervention, the asymptomatic period can be maintained for a long time and the mortality rate can be reduced.

[0026] AIDS belongs to the category of "epidemic disease" and "latent temperature disease" in traditional Chinese medicine. It is generally believed that the disease is caused by the invasion of epidemic toxins, which depletes the vital energy over time, and then the body's qi, blood, yin and yang gradually become unbalanced, and the functions of the internal organs are increasingly damaged and weakened. Traditional Chinese medicine is based on "preventing disease before it occurs" and "preventing changes after disease occurs", and takes the principles of leading evil out and nourishing vital energy. Based on this, this study observes whether HAART combined with Fuyuan Jiedu Granules can improve the number of CD4+T lymphocytes and TCM syndrome scores in asymptomatic AIDS patients, clarify its clinical efficacy, and provide a treatment prescription for the clinical treatment of AIDS.

[0027] Embodiment 1:

[0028] The Chinese medicinal composition for treating AIDS and strengthening the body's constitution and restoring the body provided by the present invention is composed of the following raw materials in parts by weight: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, and 7-10 parts of Polygala tenuifolia.

[0029] First, the following Chinese medicinal raw materials: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, 7-10 parts of Polygala tenuifolia are mixed in proportion, soaked in water for 3-4 hours, heated and decocted for 2-3 times, each time for 60 minutes, the decoctions are combined, and then allowed to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decoction to obtain a concentrated solution;

[0030] Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 60-80° C. to obtain a traditional Chinese medicine.

[0031] Embodiment 2:

[0032] The invention provides a traditional Chinese medicine composition for treating AIDS and strengthening the body's constitution. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 8 parts of raw astragalus, 7 parts of American ginseng, 8 parts of Poria, 3 parts of Ganoderma lucidum, 4 parts of Atractylodes macrocephala, 4 parts of Rhodiola rosea, 8 parts of Atractylodes lancea, 20 parts of Coix seeds, 3 parts of Magnolia officinalis, 7 parts of Pinellia ternata, 4 parts of Amomum villosum, 11 parts of Smilax glabra, 7 parts of Salvia miltiorrhiza, and 7 parts of Polygala tenuifolia.

[0033] First, the following Chinese medicinal raw materials: 8 parts of raw astragalus, 7 parts of American ginseng, 8 parts of Poria, 3 parts of Ganoderma lucidum, 4 parts of Atractylodes macrocephala, 4 parts of Rhodiola rosea, 8 parts of Atractylodes lancea, 20 parts of Coix seeds, 3 parts of Magnolia officinalis, 7 parts of Pinellia ternata, 4 parts of Amomum villosum, 11 parts of Smilax glabra, 7 parts of Salvia miltiorrhiza, 7 parts of Polygala tenuifolia, are mixed in proportion, soaked in water for 4 hours, heated and decocted twice, each time for 60 minutes, the decoctions are combined, and decocted at 80°C, then left to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decocting, wherein the density ratio of water to filtrate is 1:1.32-1.35, to obtain a concentrated solution;

[0034] Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 80° C. to obtain a traditional Chinese medicine.

[0035] Embodiment three:

[0036] The traditional Chinese medicine composition for treating AIDS and strengthening the body's constitution and restoring the body provided by the present invention comprises 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, and 10 parts of Polygala tenuifolia.

[0037] First, the following Chinese medicinal materials: 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, 10 parts of Polygala tenuifolia. Mix them in proportion, soak them in water for 4 hours, and heat and decoct them twice, each time for 60 minutes. Combine the decoctions, decoct them at 80℃, and then let them stand for 24 hours. Filter out the filtrate, add water to the filtrate in proportion for decoction, wherein the density ratio of water to filtrate is 1:1.32-1.35, and obtain a concentrated solution;

[0038] Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 80° C. to obtain a traditional Chinese medicine.

[0039] Furthermore, the amount of the soluble starch added to the concentrated solution is 10-12% of the added Chinese medicinal raw material.

[0040] Furthermore, the specific dosage form of the medicament is capsule.

[0041] Furthermore, the specific application form of the medicament is granules.

[0042] The medicinal materials in the above drugs play the following roles in the medicaments of this application;

[0043] Raw Astragalus: It has the functions of replenishing Qi, consolidating the exterior and stopping sweating, greatly nourishing the Qi of the spleen and lungs, strengthening the spleen and promoting diuresis, and controlling dampness on the skin surface and water vapor inside.

[0044] Atractylodes macrocephala: Strengthens the spleen and removes dampness, tonifies the spleen and replenishes qi.

[0045] The combination of raw Astragalus and Atractylodes can stimulate the spleen and stomach to transform qi, invigorate vitality, replenish spleen qi to transform water, move spleen qi to circulate water, raise spleen qi to descend water, and treat both internal and external water and dampness.

[0046] American ginseng: It has the effects of clearing away heat and promoting body fluid, enhancing immunity, enhancing the body's nonspecific antibodies, lowering blood sugar, lowering blood lipids, anti-fatigue, anti-oxidation, anti-arrhythmia, anti-mutation, anti-stress, and anti-hypoxia.

[0047] Poria: It has the effects of strengthening the spleen and eliminating dampness, promoting diuresis, enhancing immunity, regulating gastrointestinal function, and protecting the liver.

[0048] Ganoderma lucidum: It nourishes the qi and blood of the five internal organs, while Polygala tenuifolia calms the mind and soothes the nerves.

[0049] Rhodiola rosea: On the one hand, it nourishes qi and yin to replenish qi and blood that have been damaged by evil qi and pathogenic factors; on the other hand, it activates blood circulation and removes stasis to disperse accumulated pathogenic factors.

[0050] Atractylodes: It has the effects of drying dampness and strengthening the spleen, and promoting the yang energy in the stomach.

[0051] Coix seed: It has the effects of strengthening the spleen, draining dampness, detoxifying and dispersing nodules.

[0052] Magnolia officinalis, ginger pinellia, and tsaoko should be used together. Among them, pinellia has a pungent and mild taste, while magnolia officinalis is bitter, pungent and warm. They have the effects of pungent opening and bitter descending, drying dampness and resolving phlegm, relieving depression and dispersing nodules, and relieving bloating and fullness.

[0053] Wild Smilax glabra: It has the effects of clearing away heat and detoxifying, and Danshen has the effects of promoting blood circulation and removing blood stasis.

[0054] Salvia miltiorrhiza: It has the effect of promoting blood circulation and helping Smilax glabra to clear away heat and dampness.

[0055] Polygala: It has the effects of calming the mind, improving intelligence, connecting the heart and kidneys, removing phlegm and reducing swelling.

[0056] The above components in the present application can solve the problem to be solved in the present application after being prepared according to the ratios provided in the embodiments of the present application.

[0057] Experimental process and data

[0058] A total of 85 AIDS asymptomatic patients who were admitted to the People's Hospital of Shapotou District, Zhongwei City, Ningxia from January 2020 to December 2022 were selected and met the inclusion criteria. They were divided into a treatment group of 43 cases, including 23 males and 20 females with an average age of (33.22±4.262) years old; a control group of 42 cases, including 22 males and 20 females with an average age of (32.34±3.267) years old. The average course of disease in both groups was 4 years. There was no statistical difference in gender, age, and course of disease between the two groups (P>0.05), and they were comparable.

[0059] 1.1 Inclusion and Exclusion Criteria:

[0060] 1.1.1 Diagnostic criteria:

[0061] It complies with the AIDS diagnostic criteria in the "Guidelines for the Diagnosis and Treatment of AIDS in China (2021 Edition)".

[0062] (1) HIV antibody test is positive; (2) HIV supplementary test is positive (antibody supplementary test is positive or nucleic acid qualitative test is positive or nucleic acid quantitative test is >5000 copies / ml); (3) HIV separation test is positive. If any of the above items is met, the diagnosis can be made.

[0063] 1.1.2 Inclusion criteria

[0064] Meet the above diagnostic criteria; (2) Aged 18 to 70 years, with disease duration less than 3 years; (3) Sign the informed consent form; (4) Have no previous organic lesions.

[0065] 1.1.3 Exclusion criteria:

[0066] (1) Those who do not meet the diagnostic criteria; (2) Pregnant and lactating women; (3) Those with mental illness; (4) Those with malignant tumors; (5) Those with severe autoimmune diseases and opportunistic infectious diseases.

[0067] 1.2 Treatment methods

[0068] Control group: HAART recommended regimen: 2 NRTIs backbone drugs combined with third-class drugs. Oral lamivudine tablets, 300 mg / time, once / d; tenofovir tablets, 300 mg / time, once / d; efavirenz tablets, 600 mg / time, once / d were given. Treatment group: Aiqi Fuyuan capsules were taken orally on the basis of HAART treatment, taken with warm water, twice a day, morning and evening, 5 capsules each time. Both groups were evaluated for clinical efficacy after 24 weeks of continuous treatment.

[0069] 1.3 Observation indicators

[0070] (1) Immunological indicators: The absolute counts of CD4+ T lymphocytes were measured in both groups of patients at the end of treatment for 24 weeks.

[0071] (2) Biochemical indices: The liver function of the two groups was tested at the end of treatment.

[0072] (3) Safety assessment: Observe and record the relevant symptoms of the two groups of patients during medication, such as drowsiness, dizziness, headache, and gastrointestinal symptoms (diarrhea, nausea).

[0073] 1.4 Efficacy evaluation

[0074] Efficacy criteria:

[0075] Recovery: The white spots on the patient's skin lesions subsided by more than 90%, and the skin color returned to normal.

[0076] Significantly effective: Most of the white spots on the affected area disappeared, and the area restored to normal skin color accounts for more than 60% of the original affected area.

[0077] Effective: The white spots in the affected area have partially subsided or shrunk to a level that is 30% or less than the original affected area.

[0078] Ineffective: There is no re-pigmentation of the lesion or the edge is enlarged.

[0079] The formula for judging the therapeutic effect is: effective rate = (number of cured cases + number of markedly effective cases) / total number of patients × 100%.

[0080] 1.5 Statistical methods

[0081] Statistical analysis was performed using SPSS 25.0. The data were expressed as percentages and were tested with t test. The count data were expressed as percentages and were tested with χ2 test. All tests were two-sided and P < 0.05 was considered statistically significant.

[0082] 2. Results

[0083] 2.1 Comparison of the total efficacy of the two groups of patients before and after treatment (Table 1). The effective rate of the treatment group was 83.7%, and the effective rate of the control group was 61.9%. There was a statistically significant difference between the two groups (P < 0.05).

[0084] Table 1 Comparison of overall efficacy between the two groups before and after treatment

[0085]

[0086] 2.2 Comparison of CD4+T lymphocyte counts and efficacy between the two groups before and after treatment (Table 2, Table 3). Compared with the counts before treatment, the counts of CD4+T lymphocytes in the two groups increased after treatment, and the counts in the treatment group were higher than those in the control group (P < 0.05). The difference in CD4+T lymphocyte efficacy between the two groups was statistically significant (P < 0.05).

[0087] Table 2 CD4+T lymphocyte counts of the two groups of patients before and after treatment (cells / μL)

[0088]

[0089] Table 3 Comparison of CD4+T lymphocyte efficacy between the two groups before and after treatment

[0090]

[0091] 2.3. The TCM symptom scores of the two groups of patients before and after treatment (Table 4) showed that compared with those before treatment, the TCM symptom scores of the two groups decreased after treatment and were lower than those of the control group (P < 0.01).

[0092] Table 4 Total score of TCM symptoms in the two groups of patients before and after treatment

[0093]

[0094] 2.4. Comparison of serum creatinine levels before and after treatment between the two groups (Table 5). There was no significant difference in serum creatinine levels before treatment between the two groups (P>0.05). Compared with the levels before treatment, serum creatinine levels in both groups decreased after treatment. There was a significant difference in serum creatinine levels after treatment between the two groups (P<0.05).

[0095] Table 5 Serum creatinine levels in the two groups of patients before and after treatment μmol / L

[0096]

[0097] 2.5. Comparison of ALT levels before and after treatment between the two groups (Table 6). There was no significant difference in ALT levels before treatment between the two groups (P>0.05). Compared with the level before treatment, ALT levels in both groups decreased after treatment. There was a significant difference in ALT levels after treatment between the two groups (P<0.05).

[0098] Table 6 ALT levels of patients in the two groups before and after treatment IU / L

[0099]

[0100] 2.6. Comparison of AST levels before and after treatment between the two groups (Table 7). There was no significant difference in AST levels before treatment between the two groups (P>0.05). Compared with the level before treatment, the AST levels of the two groups decreased after treatment. There was a significant difference in AST levels after treatment between the two groups (P<0.05).

[0101] Table 7 AST levels of patients in the two groups before and after treatment (x±s) IU / L

[0102]

[0103] In both groups of patients, most of the white spots on the lesions disappeared, and the proportion of patients who recovered to normal skin color exceeded 60% of the original lesion area, achieving a significant effect.

[0104] In this embodiment, Astragalus and Atractylodes macrocephala are both the main drugs, which have the effects of strengthening the spleen and raising yang, invigorating qi and regulating blood. Astragalus greatly invigorates the spleen and lung qi, invigorates the spleen and promotes water excretion, and mainly controls the water dampness on the skin surface and the water vapor inside. And Atractylodes macrocephala mainly plays the role of invigorating the spleen and transporting dampness, invigorating the spleen and invigorating qi. Astragalus and Atractylodes macrocephala are used together to invigorate the spleen and stomach qi transformation and invigorate vitality. Poria has the effect of invigorating the spleen, penetrating dampness and calming the heart. Coix seed invigorates the spleen and penetrating dampness, detoxifies and disperses knots. Atractylodes macrocephala plays the role of drying dampness and invigorating the spleen, and can promote the yang qi in the stomach. Adding American ginseng to the formula plays the role of clearing heat and promoting body fluid. Ganoderma lucidum in the formula can nourish the qi and blood of the five internal organs, and Polygala tenuifolia can calm the mind and tranquilize the nerves. Rhodiola rosea in the formula, on the one hand, plays the role of invigorating qi and nourishing yin, to nourish the qi and blood damaged by the evil qi of epidemic toxicity; on the other hand, it plays the role of promoting blood circulation and removing blood stasis, to disperse the epidemic toxicity that gathers.

[0105] The Chinese medicine composition provided in the present application is prepared with Magnolia officinalis, Pinellia ternata and Amomum villosum. Pinellia ternata tastes pungent and flat, while Magnolia officinalis is bitter and pungent and warm. The compatibility of Magnolia officinalis, Pinellia ternata and Amomum villosum together warms the middle and replenishes qi, eliminates phlegm and lowers qi, opens pungent and descends bitterly, dries dampness and resolves phlegm, relieves depression and disperses knots, and can eliminate swelling and fullness. AIDS is an epidemic toxin that attacks people. It is easy to combine with the six evil qi to cause disease, consume qi and injure blood, and cause qi and blood to stagnate. In the compatibility, Smilax glabra plays the role of clearing away heat and detoxifying, and Salvia miltiorrhiza has the effect of promoting blood circulation and removing blood stasis. Salvia miltiorrhiza has the effect of promoting blood circulation, and plays the role of clearing heat and removing dampness together with Smilax glabra.

[0106] It can be seen that the Chinese medicine composition provided by the present invention is used in combination with various ingredients in the treatment of AIDS, which has the effects of invigorating qi and restoring the body, detoxifying and strengthening the body. The experimental results show that the Chinese medicine composition can prevent the skin lesions from further expanding during the treatment process, and the skin lesions gradually return to normal skin color, the prescription is thorough and reasonable, and there are no side effects, which is suitable for patients to take for a long time. At the same time, the Chinese medicine composition also has the effects of invigorating qi and restoring the body, detoxifying and strengthening the body, and the Chinese medicine Aiqi Fuyuan Capsule is combined with HAART to treat AIDS asymptomatic patients, which can reduce the liver function damage caused by HAART, improve the patient's immune function, and improve clinical related symptoms. At the same time, the Chinese medicine composition has stable efficacy, safe and reliable, convenient to take, and therapeutic effect.

[0107] Those skilled in the art will readily appreciate other embodiments of the present application after considering the specification and practicing the application disclosed herein. The present application is intended to cover any variations, uses or adaptations of the present application, which follow the general principles of the present application and include common knowledge or customary technical means in the art disclosed in the present application. The specification and examples are to be regarded as exemplary only, and the true scope of the present application is indicated by the claims.

[0108] It should be understood that the present application is not limited to the precise structure described and shown above, and various modifications and changes can be made without departing from its scope. The above embodiments of the present application do not constitute a limitation on the scope of protection of the present application.

Claims

1. A Chinese medicine composition for treating AIDS, characterized in that: The invention is composed of the following raw materials in parts by weight: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, and 7-10 parts of Polygala tenuifolia.

2. The Chinese medicine composition for treating AIDS and strengthening the body according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 8 parts of raw astragalus, 7 parts of American ginseng, 8 parts of Poria, 3 parts of Ganoderma lucidum, 4 parts of Atractylodes macrocephala, 4 parts of Rhodiola rosea, 8 parts of Atractylodes lancea, 20 parts of Coix seeds, 3 parts of Magnolia officinalis, 7 parts of Pinellia ternata, 4 parts of Amomum villosum, 11 parts of Smilax glabra, 7 parts of Salvia miltiorrhiza, and 7 parts of Polygala tenuifolia.

3. The Chinese medicine composition for treating AIDS and strengthening the body according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, and 10 parts of Polygala tenuifolia.

4. A method for preparing a Chinese medicine composition for treating AIDS, characterized in that: The steps include: First, the following Chinese medicinal raw materials: 8-10 parts of raw astragalus, 7-10 parts of American ginseng, 8-10 parts of Poria, 3-6 parts of Ganoderma lucidum, 4-6 parts of Atractylodes macrocephala, 4-6 parts of Rhodiola rosea, 8-10 parts of Atractylodes lancea, 20-30 parts of Coix seeds, 3-6 parts of Magnolia officinalis, 7-9 parts of Pinellia ternata, 4-6 parts of Amomum villosum, 11-15 parts of Smilax glabra, 7-10 parts of Salvia miltiorrhiza, 7-10 parts of Polygala tenuifolia are mixed in proportion, soaked in water for 3-4 hours, heated and decocted for 2-3 times, each time for 60 minutes, the decoctions are combined, and then allowed to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decoction to obtain a concentrated solution; Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 60-80° C. to obtain a traditional Chinese medicine.

5. The method for preparing the Chinese medicine composition for treating AIDS and strengthening the body according to claim 4, characterized in that: The steps include: First, the following Chinese medicinal raw materials: 10 parts of raw astragalus, 10 parts of American ginseng, 10 parts of Poria, 6 parts of Ganoderma lucidum, 6 parts of Atractylodes macrocephala, 6 parts of Rhodiola rosea, 10 parts of Atractylodes lancea, 30 parts of Coix seeds, 6 parts of Magnolia officinalis, 9 parts of Pinellia ternata, 6 parts of Amomum villosum, 15 parts of Smilax glabra, 10 parts of Salvia miltiorrhiza, 10 parts of Polygala tenuifolia are mixed in proportion, soaked in water for 4 hours, heated and decocted twice, each time for 60 minutes, the decoctions are combined, and decocted at 80°C, then allowed to stand for 24 hours, the filtrate is filtered out, and water is added to the filtrate in proportion for decocting, wherein the density ratio of water to filtrate is 1:1.32-1.35, to obtain a concentrated solution; Secondly, the concentrated solution is added with soluble starch and mixed evenly, and then placed in a microwave vacuum dryer and dried at 80° C. to obtain a traditional Chinese medicine.

6. The method for preparing the Chinese medicinal composition for treating AIDS and strengthening the body according to claim 5, characterized in that: The amount of the soluble starch added to the concentrated solution is 10-12% of the added Chinese medicinal raw material.

7. The method for preparing the Chinese medicinal composition for treating AIDS according to any one of claims 4 to 6, characterized in that: The specific application dosage form of the Chinese medicine is capsule.

8. The method for preparing the traditional Chinese medicine composition for treating AIDS according to any one of claims 4 to 6, characterized in that: The specific application dosage form of the Chinese medicine is granules.

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