Polyphenol feed mildew inhibitor, preparation method thereof and poultry feed

Abstract

The invention discloses a polyphenol feed mildew preventive, a preparation method thereof and poultry feed, and belongs to the field of feed. The polyphenol feed mildew inhibitor comprises a core material and a wall material, and the core material comprises the following raw materials by weight: 25-50 parts of a polyphenol lettuce extract; 10 to 20 parts of plant polysaccharide; 2-5 parts of long-chain polyunsaturated fatty acid; the wall material is prepared from the following raw materials in parts by weight: 15 to 25 parts of chitosan; 5 to 10 parts of phytosterol; 100 to 200 parts of a rubber material; the glue material comprises one or a compound of more of sodium alginate, starch, gelatin, Arabic gum and maltodextrin. The feed mildew preventive has the effect of reducing the harm risk of the feed mildew preventive to the human body.

Description

Technical Field

[0001] The present application relates to the field of feed, and in particular to a polyphenol feed mildew inhibitor, a preparation method thereof, and poultry feed. Background Art

[0002] In the process of livestock and poultry breeding, feed is an indispensable material basis. However, because feed is rich in nutrients, it is very easy to become a breeding ground for mold. Mold not only causes feed deterioration and nutrient loss, but also produces a variety of toxic metabolites, which have a serious impact on the health of livestock and poultry. Therefore, feed mold inhibitors are often added to feed to reduce the mold content of feed and extend the shelf life.

[0003] Existing antifungal agents often contain ingredients that have adverse effects on the human body, such as organophosphates and oxalic acid. Since breeders need to come into contact with feed frequently, the addition of such antifungal agents will increase the risk of harm to breeders and the application effect is poor. Summary of the invention

[0004] In order to reduce the risk of harm to human body caused by feed mildew inhibitors, the present application provides a polyphenol feed mildew inhibitor, a preparation method thereof and poultry feed.

[0005] In the first aspect, the polyphenol feed mildew inhibitor provided in the present application adopts the following technical solution: A polyphenol feed mildew inhibitor, comprising a core material and a wall material, wherein the core material comprises the following raw materials in parts by weight: 25-50 parts of polyphenol lettuce extract; 10-20 parts of plant polysaccharides; 2-5 parts of long-chain polyunsaturated fatty acids; The wall material comprises the following raw materials in parts by weight: 15-25 parts of chitosan; 5-10 parts of phytosterols; 100-200 parts of adhesive material; The glue material includes one or more compounds selected from the group consisting of sodium alginate, starch, gelatin, gum arabic and maltodextrin.

[0006] By adopting the above technical scheme, the polyphenol lettuce extract is rich in quercetin, chlorogenic acid, anthocyanin, chicoric acid and other polyphenols, which have a good antibacterial effect on feed. The polyphenol lettuce extract is compounded with plant polysaccharides and long-chain polyunsaturated fatty acids to obtain a feed mildew inhibitor. This ingredient comes from natural substances and is used in feed to greatly reduce the harm to the human body, while meeting the needs of antibacterial and mildew prevention.

[0007] By wrapping the core material with wall material, the mildew inhibitor takes on a microcapsule structure, protecting components such as polyphenols in the core material that are susceptible to environmental influences. The long-chain polyunsaturated fatty acids and plant sterols are combined through their fat-soluble properties to improve the compatibility of the core material and the wall material, allowing the antibacterial active ingredients to be slowly released into the feed, thereby improving the durability and anti-interference properties of the antibacterial and mildew-proofing agent.

[0008] Optionally, the source material of the polyphenol lettuce alcohol extract is polyphenol lettuce, and the total polyphenol content of the polyphenol lettuce is 2-6 mg / g.

[0009] By adopting the above technical scheme, the polyphenol content of general lettuce on the market is generally less than 1 mg / g, and the polyphenol content in polyphenol lettuce is much higher than that of ordinary lettuce, especially the high content of polyphenols such as quercetin, chlorogenic acid, anthocyanin and chicoric acid, which can not only play a good antibacterial and mildew-proof effect on feed, but also the polyphenol lettuce extract can be eaten by poultry and livestock, so that poultry and livestock can obtain polyphenol nutrition, and the addition of long-chain polyunsaturated fatty acids can improve the feeding effect.

[0010] Optionally, the long-chain polyunsaturated fatty acid is selected from one or more of α-linolenic acid, arachidonic acid and eicosapentaenoic acid.

[0011] By adopting the above technical scheme, the above long-chain polyunsaturated fatty acids can be combined with polyphenol lettuce extract to obtain antibacterial and anti-mildew effects, and when α-linolenic acid is selected, the mildew inhibitor is more durable and can cope with more severe environments.

[0012] Optionally, the plant polysaccharide is selected from one or more of wolfberry polysaccharide, auricularia auricula polysaccharide, kelp polysaccharide and tremella polysaccharide.

[0013] By adopting the above technical scheme, the above plant polysaccharides can play a good role in regulating the body of livestock and poultry, improve the absorption of feed nutrients by livestock and poultry, especially the absorption of polyphenol components in polyphenol lettuce extract.

[0014] Optionally, the plant sterol is β-sitosterol.

[0015] By adopting the above technical scheme, β-sitosterol has good biological activity. When used in combination with α-linolenic acid, the fat solubility of the two is used to promote the interface fusion of the core material and the wall material, thereby improving the stability of the mildew inhibitor. At the same time, the insulating effect of the wall material on the core material is appropriately reduced, thereby achieving the continuous release of the antibacterial effective ingredients of the core material, producing a continuous antibacterial and mildew-proof effect on the feed, and also improving the feeding effect, balancing the hormone levels of poultry and livestock and improving immunity, especially having a good effect on the egg production and live embryos of laying hens.

[0016] Optionally, the chitosan is carboxymethyl chitosan.

[0017] By adopting the above technical solution, carboxymethyl chitosan has good film-forming property, is suitable for forming wall material together with adhesive material, and improves the stability of the microcapsule structure of the mildew inhibitor.

[0018] Optionally, the adhesive material is selected from sodium alginate, starch and gelatin in a weight ratio of (0.5-1):(1.2-1.5):1.

[0019] By adopting the above technical solution and selecting a compound of sodium alginate, starch and gelatin as the adhesive material, the wrapping ability and stability of the wall material on the core material can be improved.

[0020] In the second aspect, the present application provides a method for preparing a polyphenol feed mildew inhibitor using the following technical scheme: A method for preparing a polyphenol feed mildew inhibitor comprises the following steps: Mixing the polyphenol lettuce extract, the plant polysaccharide, the long-chain polyunsaturated fatty acid and the first solvent, and stirring evenly to obtain a core material mixed liquid; Mixing chitosan, phytosterol, glue and the second solvent, stirring evenly to obtain a wall material mixed solution; The core material mixture is added dropwise to the wall material mixture while stirring, sifted after the addition is completed, and then subjected to high pressure homogenization to obtain a homogenous emulsion, and the homogenous emulsion is spray-dried to obtain a polyphenol feed mildew inhibitor.

[0021] By adopting the above technical scheme, the core material mixed liquid and the wall material mixed liquid are first obtained separately, and the core material mixed liquid is added to the wall material mixed liquid to form a coating structure. Then, by homogenization and spray drying, a mildew inhibitor with a microcapsule structure is obtained, which is suitable for poultry and livestock feed and has an antibacterial and mildew-proof effect.

[0022] Optionally, the weight ratio of the core material to the first solvent is 1:(5-10).

[0023] Optionally, the first solvent is an ethanol aqueous solution with a mass concentration of 20% to 30%.

[0024] Optionally, the weight ratio of the wall material to the second solvent is 1:(15-20).

[0025] Optionally, the second solvent is an ethanol aqueous solution with a mass concentration of 40% to 50%.

[0026] Optionally, the preparation method of the polyphenol lettuce alcohol extract is: crush the polyphenol lettuce to obtain polyphenol lettuce powder, add it to an ethanol aqueous solution with a mass concentration of 45% to 65%, soak it at 20 to 30°C for 1 to 3 hours, then filter out the polyphenol lettuce powder, keep the ethanol aqueous solution after soaking for use, then place the polyphenol lettuce powder soaked in the ethanol aqueous solution in a new ethanol aqueous solution and soak it for 1 to 3 hours, repeat the above steps 1 to 4 times, place the polyphenol lettuce powder in a new ethanol aqueous solution, soak it at 50 to 60°C for 1 to 3 hours, then filter out the polyphenol lettuce powder, combine the soaked ethanol aqueous solutions and concentrate them until the liquid is viscous to obtain the polyphenol lettuce alcohol extract.

[0027] By adopting the above technical scheme, the polyphenol lettuce is first extracted at room temperature or below to extract the polyphenol components that are more affected by temperature, and then richer polyphenols are extracted by heating and soaking, thereby improving the extraction effect of the polyphenol lettuce and enriching the efficacy of the polyphenol lettuce extract.

[0028] In the third aspect, the present application provides a poultry feed adopting the following technical solution: A poultry feed using a polyphenol feed mildew inhibitor, wherein the weight proportion of the polyphenol feed mildew inhibitor in the poultry feed is 0.5-1%.

[0029] By adopting the above technical solution, since the polyphenol feed mildew inhibitor is composed of natural ingredients, the added amount of the mildew inhibitor can be appropriately increased, which not only meets the needs of antibacterial and mildew prevention, but also improves its effect on poultry nutrient absorption.

[0030] In summary, this application has the following beneficial effects: 1. This application uses polyphenol lettuce extract as one of the components of the mildew inhibitor. The polyphenol lettuce extract is rich in quercetin, chlorogenic acid, anthocyanin, chicoric acid and other polyphenols, which have a good antibacterial effect on feed. The polyphenol lettuce extract is compounded with plant polysaccharides and long-chain polyunsaturated fatty acids to obtain a feed mildew inhibitor. This component comes from natural substances and is used in feed to greatly reduce the harm to the human body, while meeting the needs of antibacterial and mildew prevention. The wall material is used to wrap the core material, so that the mildew inhibitor has a microcapsule structure, and the polyphenols and other components in the core material that are susceptible to environmental influences are protected. The long-chain polyunsaturated fatty acids and plant sterols are combined through the fat-soluble characteristics to improve the compatibility of the core material and the wall material, so that the antibacterial active ingredients are slowly released into the feed, and the durability and anti-interference of the antibacterial and mildew prevention are improved.

[0031] 2. When long-chain polyunsaturated fatty acids and phytosterols are selected as α-linolenic acid and β-sitosterol respectively, the mildew inhibitor is more durable and can cope with more severe environments. It also improves feeding results, balances hormone levels of poultry and livestock, and enhances immunity. It has a particularly good effect on egg production and live embryos of laying hens. DETAILED DESCRIPTION

[0032] The present application is described in further detail below.

[0033] The polyphenol lettuce was purchased from Zhejiang Jiameishan Plant Technology Co., Ltd. The total polyphenol content of the polyphenol lettuce was 2-6 mg / g. The polyphenol lettuce used in the following preparation example was tested and the total polyphenol content was 2 mg / g.

[0034] Preparation Example 1 The preparation method of polyphenol lettuce extract comprises the following steps: The polyphenol lettuce was crushed into polyphenol lettuce powder, added into a 65% ethanol solution, the weight ratio of the polyphenol lettuce powder to the ethanol solution being 1:15, and soaked at 20°C for 1 hour. The polyphenol lettuce powder was then filtered out, the soaked ethanol solution was collected for later use, and the polyphenol lettuce powder was soaked in a new ethanol solution for 1 hour. After repeating the above steps 4 times, the polyphenol lettuce powder was placed in a new ethanol-water solution, soaked at 60°C for 1 hour, and then the polyphenol lettuce powder was filtered out. The above soaked ethanol solutions were combined, concentrated to a liquid at 40°C and negative pressure, and the viscosity was measured by a Tu-4 viscosity cup for 30 seconds to obtain a polyphenol lettuce extract.

[0035] The total polyphenol content of polyphenol lettuce extract is 58.27 mg / g, including 13.78 mg / g quercetin, 6.03 mg / g chlorogenic acid, 7.15 mg / g anthocyanin, and 6.15 mg / g chicoric acid.

[0036] Preparation Example 2 The preparation method of polyphenol lettuce extract comprises the following steps: The polyphenol lettuce was crushed into polyphenol lettuce powder, added into a 45% ethanol solution, the weight ratio of the polyphenol lettuce powder to the ethanol solution being 1:15, and soaked at 30°C for 3 hours. The polyphenol lettuce powder was then filtered out, the soaked ethanol solution was collected for later use, and the polyphenol lettuce powder was soaked in a new ethanol solution for 3 hours. The above steps were repeated once, and the polyphenol lettuce powder was placed in a new ethanol-water solution, soaked at 50°C for 3 hours, and then the polyphenol lettuce powder was filtered out. The ethanol solutions after soaking were combined, concentrated to a liquid at 40°C and negative pressure, and the viscosity was measured by a Tu-4 viscosity cup for 30 seconds to obtain a polyphenol lettuce extract.

[0037] The total polyphenol content of polyphenol lettuce extract is 55.30 mg / g, including 12.64 mg / g quercetin, 5.62 mg / g chlorogenic acid, 7.02 mg / g anthocyanin, and 5.88 mg / g chicoric acid.

[0038] Preparation Example 3 Preparation method of polyphenol lettuce extract The difference between this comparative preparation example and preparation example 1 is that ordinary lettuce is used instead of polyphenol lettuce to obtain ordinary lettuce extract.

[0039] The total polyphenol content of common lettuce is 0.90 mg / g, and the total polyphenol content of common lettuce alcohol extract is 20.50 mg / g, including 2.63 mg / g quercetin, 1.56 mg / g chlorogenic acid, 1.81 mg / g anthocyanin and 1.05 mg / g chicoric acid.

[0040] Comparative Preparation Example The method for preparing polyphenol lettuce processed material comprises the following steps The polyphenol lettuce is freeze-dried at -50°C for 3 hours, and then ground and sieved to obtain a powder with a particle size of 10-50 μm as a polyphenol lettuce treated material.

[0041] Example 1 A polyphenol nutritional supplement comprises the following steps: Weigh 25 g of polyphenol lettuce extract, 10 g of plant polysaccharides, and 2 g of long-chain polyunsaturated fatty acids as raw materials for the core material.

[0042] The polyphenol lettuce alcohol extract is from Preparation Example 1; the plant polysaccharide is wolfberry polysaccharide; and the long-chain polyunsaturated fatty acid is α-linolenic acid.

[0043] The raw material of the core material is mixed with 185g of the first solvent, and stirred at 3000 rpm for 10 minutes to obtain a core material mixed solution. The first solvent is an ethanol aqueous solution with a mass concentration of 20%.

[0044] Weigh 15 g of chitosan, 5 g of phytosterols, and 100 g of glue as raw materials for the wall material.

[0045] The chitosan is carboxymethyl chitosan, the phytosterol is β-sitosterol, and the adhesive material is sodium alginate, starch and gelatin mixed in a weight ratio of 0.5:1.2:1.

[0046] The raw material of the wall material is mixed with 1800g of the second solvent, and stirred at 3000rpm for 10min to obtain a wall material mixed solution. The second solvent is an ethanol aqueous solution with a mass concentration of 40%.

[0047] The core material mixture was added dropwise while stirring the wall material mixture at 9000 rpm. After the addition was completed, it was sieved through a 150-mesh sieve, and the filtrate was added to a high-pressure homogenizer with a homogenization pressure of 9 MPa and a homogenization time of 2 min to obtain a homogenous emulsion.

[0048] The homogeneous emulsion is spray-dried to obtain microcapsule powder, and the obtained microcapsule powder is a polyphenol feed mildew inhibitor.

[0049] Example 2 The difference between this embodiment and embodiment 1 is that the amounts of raw materials used are different.

[0050] The amount of raw materials used in the core material: 50g of polyphenol lettuce extract, 20g of plant polysaccharides, and 5g of long-chain polyunsaturated fatty acids.

[0051] The polyphenol lettuce alcohol extract is from Preparation Example 2; the plant polysaccharide is Auricularia auricula polysaccharide; and the long-chain polyunsaturated fatty acid is α-linolenic acid.

[0052] The raw material of the core material is mixed with 750 g of a first solvent, which is an ethanol aqueous solution with a mass concentration of 20%.

[0053] The amount of raw materials used in the wall material: 25g chitosan, 10g phytosterol, and 200g glue.

[0054] The chitosan is carboxymethyl chitosan, the phytosterol is β-sitosterol, and the adhesive material is sodium alginate, starch and gelatin mixed in a weight ratio of 1:1.5:1.

[0055] The raw material of the wall material is mixed with 4700 g of a second solvent, which is an ethanol aqueous solution with a mass concentration of 20%.

[0056] Example 3 The difference between this embodiment and embodiment 1 is that the amounts of raw materials used are different.

[0057] The amount of raw materials used in the core material: 30g of polyphenol lettuce extract, 15g of plant polysaccharides, and 4g of long-chain polyunsaturated fatty acids.

[0058] The polyphenol lettuce alcohol extract is from Preparation Example 1; the plant polysaccharide is wolfberry polysaccharide; and the long-chain polyunsaturated fatty acid is α-linolenic acid.

[0059] The raw material of the core material is mixed with 245 g of a first solvent, which is an ethanol aqueous solution with a mass concentration of 20%.

[0060] The amount of raw materials used in the wall material: chitosan 20g, phytosterol 8g, and glue 140g.

[0061] The chitosan is carboxymethyl chitosan, the phytosterol is β-sitosterol, and the adhesive material is sodium alginate, starch and gelatin mixed in a weight ratio of 0.5:1.2:1.

[0062] The raw material of the wall material is mixed with 2520 g of a second solvent, which is an ethanol aqueous solution with a mass concentration of 20%.

[0063] Example 4 The difference between this embodiment and embodiment 3 is that the long-chain polyunsaturated fatty acid in this embodiment is arachidonic acid.

[0064] Example 5 The difference between this embodiment and embodiment 3 is that the long-chain polyunsaturated fatty acid in this embodiment is eicosapentaenoic acid.

[0065] Example 6 The difference between this embodiment and embodiment 3 is that the plant sterol in this embodiment is stigmasterol.

[0066] Comparative Example 1 The difference between this comparative example and Example 3 is that the polyphenol lettuce extract in this comparative example comes from Preparation Example 3.

[0067] Comparative Example 2 The difference between this comparative example and Example 3 is that the polyphenol lettuce processed material prepared in the comparative preparation example is used in this comparative example to replace the polyphenol lettuce extract, and the amount of the polyphenol lettuce processed material used is 30 g.

[0068] Comparative Example 3 The difference between this comparative example and Example 3 is that in this comparative example, polyphenol lettuce extract is used to replace α-linolenic acid, and the amount of polyphenol lettuce extract used is 34 g.

[0069] Comparative Example 4 The difference between this comparative example and Example 3 is that in this comparative example, polyphenol lettuce extract is used to replace wolfberry polysaccharide, and the amount of polyphenol lettuce extract used is 45g.

[0070] Comparative Example 5 The difference between this comparative example and Example 3 is that in this comparative example, carboxymethyl chitosan is used to replace β-sitosterol, and the amount of carboxymethyl chitosan used is 28 g.

[0071] Application Examples A poultry feed comprising the following raw materials: 2kg corn, 2kg sorghum, 1kg soybean meal, 0.5kg puffed soybeans, 0.3kg fish meal, 0.1kg calcium carbonate.

[0072] Based on the total weight of the above raw materials, 1% by weight of polyphenol feed mildew inhibitor is added.

[0073] The polyphenol feed mildew inhibitors derived from Examples 1-6 and Comparative Examples 1-5 respectively obtain poultry feeds of Application Examples 1-6 and Comparative Application Examples 1-5.

[0074] Effect test With reference to GB13078-2017 Feed Hygiene Standard, the mold content and bacterial content of poultry feed corresponding to Example 1-6 and Comparative Application Example 1-5 were tested. The test was divided into 4 times, corresponding to 4 different storage times of poultry feed, namely day 0, day 25, day 50 and day 75. The results are shown in Tables 1 and 2.

[0075] Table 1 Table 2 Combining Table 1 and Table 2, it can be seen from the results of Application Example 3 and Comparative Application Examples 1-5 that in order to achieve the antibacterial and antifungal effects of the feed antifungal agent and the long-term persistence of the antibacterial and antifungal effects, it is indispensable to use the synergistic effect of the polyphenol lettuce extract, plant polysaccharides and long-chain polyunsaturated fatty acids in the core material, and it is indispensable to use plant sterols as the composition of the wall material to achieve good compatibility between the wall material and the core material. The mold content of the feed in Application Example 3 was still less than 1×10 3 cfu / g, the bacterial content is still less than 1×10 5 cfu / g, so it has a significant effect in the long-term antibacterial and anti-mildew properties, which exceeds the current shelf life of feed which can usually only be stored for one to two months.

[0076] In addition, the wall materials and core materials are made from natural substances, which greatly reduces the harm to the human body.

[0077] By comparing Application Example 3 with Application Examples 4-6, it can be seen that after α-linolenic acid is selected as the long-chain polyunsaturated fatty acid, the synergistic effect of polyphenol lettuce extract, plant polysaccharides and long-chain polyunsaturated fatty acids is stronger, and the long-term antibacterial and mildew prevention effect is better; similarly, after β-sitosterol is selected as the plant sterol, the durability of the feed mildew inhibitor is also improved.

[0078] 120 44-week-old Hailan brown laying hens were selected and randomly divided into 12 groups, of which 11 groups were fed with poultry feed added with polyphenol feed mildew inhibitors in Application Examples 1-6 and Comparative Application Examples 1-5, and the remaining group was fed with poultry feed without polyphenol feed mildew inhibitors as a control group. Feeding was done twice a day, eggs were picked once, and the feeding lasted for 63 days. Eggs laid by each group were collected every day from the 60th day, incubated under the same conditions, and the live embryo rate of each group was recorded and calculated. The IL-6 concentration in the blood of laying hens was tested on the 63rd day. The results are shown in Table 3.

[0079] Table 3 Combined with Table 3, by comparing the results of Application Example 3 with Comparative Application Examples 1-5 and the control group, it can be seen that in addition to providing antibacterial and anti-mildew effects, the feed mildew inhibitor can also provide additional nutrients for poultry. Taking the laying hens in the test as an example, it can balance the hormone levels such as estrogen in the laying hens, thereby improving the live embryo rate, and the concentration of IL-6 pro-inflammatory factors is reduced, reflecting that the immune ability of laying hens has been improved.

[0080] Comparing Application Example 3 with Application Examples 4-6, it can be seen that the selection of α-linolenic acid as long-chain polyunsaturated fatty acids and β-sitosterol as phytosterols can also improve the survival rate of embryos and immune capacity.

[0081] This specific implementation manner is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the specific implementation manner as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A polyphenol feed mildew inhibitor, characterized in that: It comprises a core material and a wall material, wherein the core material comprises the following raw materials in parts by weight: 25-50 parts of polyphenol lettuce extract; 10-20 parts of plant polysaccharides; 2-5 parts of long-chain polyunsaturated fatty acids; The wall material comprises the following raw materials in parts by weight: Chitosan 15-25 parts; Phytosterols 5-10 parts; 100~200 copies of adhesive material; The glue material includes one or more compounds selected from the group consisting of sodium alginate, starch, gelatin, gum arabic and maltodextrin.

2. A polyphenol nutritional supplement according to claim 1, characterized in that: The source material of the polyphenol lettuce alcohol extract is polyphenol lettuce, and the total polyphenol content of the polyphenol lettuce is 2-6 mg / g.

3. The polyphenol feed mildew inhibitor according to claim 1, characterized in that: The long-chain polyunsaturated fatty acid is selected from one or more of α-linolenic acid, arachidonic acid and eicosapentaenoic acid.

4. The polyphenol feed mildew inhibitor according to claim 1, characterized in that: The plant polysaccharide is selected from one or more of wolfberry polysaccharide, auricularia auricula polysaccharide, kelp polysaccharide and tremella polysaccharide.

5. The polyphenol feed mildew inhibitor according to claim 1, characterized in that: The plant sterol is β-sitosterol.

6. The polyphenol feed mildew inhibitor according to claim 1, characterized in that: The chitosan is carboxymethyl chitosan.

7. The polyphenol feed mildew inhibitor according to claim 1, characterized in that: The adhesive material is selected from sodium alginate, starch and gelatin in a weight ratio of (0.5~1):(1.2~1.5):

1.

8. A method for preparing the polyphenol feed mildew inhibitor according to any one of claims 1 to 7, characterized in that: The following steps are involved: Mixing the polyphenol lettuce extract, the plant polysaccharide, the long-chain polyunsaturated fatty acid and the first solvent, and stirring evenly to obtain a core material mixed liquid; Mixing chitosan, phytosterol, glue and the second solvent, stirring evenly to obtain a wall material mixed solution; The core material mixture is added dropwise to the wall material mixture while stirring, sifted after the addition is completed, and then subjected to high pressure homogenization to obtain a homogenous emulsion, and the homogenous emulsion is spray-dried to obtain a polyphenol feed mildew inhibitor.

9. The method for preparing a polyphenol feed mildew inhibitor according to claim 8, characterized in that: The preparation method of the polyphenol lettuce alcohol extract is as follows: the polyphenol lettuce is crushed to obtain the polyphenol lettuce powder, the powder is added into an ethanol aqueous solution with a mass concentration of 45% to 65%, and the powder is soaked at 20 to 30° C. for 1 to 3 hours, and then the polyphenol lettuce powder is filtered out, the ethanol aqueous solution after soaking is reserved, and then the polyphenol lettuce powder soaked in the ethanol aqueous solution is placed in a new ethanol aqueous solution and soaked for 1 to 3 hours, after repeating the above steps 1 to 4 times, the polyphenol lettuce powder is placed in a new ethanol aqueous solution and soaked at 50 to 60° C. for 1 to 3 hours, and then the polyphenol lettuce powder is filtered out, and the ethanol aqueous solution after soaking is combined and concentrated until the liquid is viscous to obtain the polyphenol lettuce alcohol extract.

10. A poultry feed using the polyphenol feed mildew inhibitor according to any one of claims 1 to 7, characterized in that: The weight proportion of the polyphenol feed mildew inhibitor in poultry feed is 0.5-1%.

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