Oral care composition and preparation method thereof

Abstract

The invention discloses an oral care composition and a preparation method thereof, and belongs to the technical field of oral antibacterial agents. Comprising 50-80 parts of a traditional Chinese medicine extract, 10-20 parts of a humectant, 5-50 parts of water and 0-20 parts of an auxiliary material, the traditional Chinese medicine comprises the following components in parts by weight: 30-50 parts of honeysuckle, 10-30 parts of herba violae, 10-30 parts of dandelion, 10-30 parts of folium isatidis, 1-10 parts of golden cypress, 1-10 parts of radix sophorae flavescentis, 1-10 parts of scutellaria baicalensis and 5-20 parts of mint. The traditional Chinese medicine extracts in a specific proportion are adopted, oral bacteria can be inhibited in daily nursing, breath can be cleared, and oral cancer can be effectively prevented. When serious oral cavity diseases such as stomatitis, oral mucosa hyperemia and edema occur, the traditional Chinese medicine can relieve pain and diminish inflammation, rapidly diminish swelling and effectively treat diseases.

Description

Technical Field

[0001] The invention relates to the technical field of oral antibacterial agents, and in particular to an oral care composition and a preparation method thereof. Background Art

[0002] Most oral and dental diseases are caused by untimely cleaning, which leads to the accumulation of bacteria, dirt, impurities (food residues), etc. in the oral cavity, which in turn leads to various inflammations and other complications, and then people suffer from dental diseases. Oral care sprays, oral repair antibacterial liquids, mouthwashes, etc. are the main related products for the prevention and treatment of oral diseases. This type of product mainly focuses on daily care and prevention effects such as oral antibacterial and fresh breath. It has poor therapeutic effects on more serious stomatitis, oral mucosal congestion, edema and other diseases. The treatment of this type of disease is also taken orally to improve the body's immunity to achieve the effect of treatment. Therefore, it is urgent to develop a care solution for the prevention and treatment of oral diseases. Summary of the invention

[0003] In order to solve the above problems, the present invention provides an oral care composition and a preparation method thereof, which can effectively inhibit bacteria and treat oral diseases.

[0004] In order to achieve the above object, the present invention is implemented by the following technical solutions:

[0005] An oral care composition comprises at least the following components: 50-80 parts of a traditional Chinese medicine extract, 10-20 parts of a moisturizer, 5-50 parts of water, and 0-20 parts of an auxiliary material.

[0006] Furthermore, the Chinese medicine in the Chinese medicine extract includes the following components in parts by weight: 30-50 parts of honeysuckle, 10-30 parts of Viola yedoensis, 10-30 parts of dandelion, 10-30 parts of isatis indigotica, 1-10 parts of phellodendron, 1-10 parts of sophora flavescens, 1-10 parts of scutellaria baicalensis, and 5-20 parts of mint.

[0007] Furthermore, the Chinese medicine in the Chinese medicine extract includes the following components in parts by weight: 45-50 parts of honeysuckle, 20-30 parts of Viola yedoensis, 10-20 parts of dandelion, 20-30 parts of isatis indigotica, 3-8 parts of phellodendron, 3-8 parts of sophora flavescens, 3-8 parts of scutellaria baicalensis, and 10-15 parts of mint.

[0008] Furthermore, the Chinese medicine in the Chinese medicine extract includes the following components in parts by weight: 50 parts of honeysuckle, 30 parts of Viola yedoensis, 15 parts of dandelion, 30 parts of isatis indigotica, 5 parts of phellodendron, 5 parts of sophora flavescens, 5 parts of scutellaria baicalensis, and 10 parts of mint.

[0009] Furthermore, the preparation method of the Chinese medicine extract comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, Phellodendron chinense, Sophora flavescens, Scutellaria baicalensis and mint to water with a solid-liquid ratio of 1:1-20, boiling for 1-2h, filtering and taking the filtrate; repeating the boiling for 3-5 times, combining the filtrate to obtain the Chinese medicine extract of the present invention.

[0010] Furthermore, the moisturizing agent includes any one or more of glycerin, sorbitol, propylene glycol, xylitol, and polyethylene glycol.

[0011] Furthermore, the auxiliary materials include any one or more of pharmaceutically acceptable diluents, carriers, excipients, anti-allergic agents, preservatives, adsorbents, sweeteners, and flavors.

[0012] Furthermore, the preservative includes any one or more of potassium benzoate, sodium benzoate, and potassium sorbate.

[0013] Furthermore, the sweetener includes any one or more of sucrose, xylitol, saccharin sodium, and sorbitol.

[0014] Furthermore, the anti-allergic agent includes any one or more of poloxamer 407 and C10-C16 alkyl betaine.

[0015] Further, the care comprises oral rinse, mouthwash, mouth freshener or toothpaste or tooth paint.

[0016] The present invention also protects a method for preparing an oral care composition, comprising the following steps:

[0017] (1) adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, phellodendron, sophora flavescens, scutellaria baicalensis and mint to water at a solid-liquid ratio of 1:1-20, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3-5 times, combining the filtrates, and sterilizing to obtain the Chinese medicine extract of the present invention;

[0018] (2) After the Chinese herbal extract is cooled and diluted 1-50 times, a moisturizer, an auxiliary material and water are added and mixed thoroughly, and the mixture is filtered to obtain the oral care composition of the present invention. Furthermore, the decoction composition obtained by boiling is prepared into a paste, granules, tablets or capsules by a conventional preparation method.

[0019] Honeysuckle contains luteolin, 1% inositol, volatile oil, terpenoids, phenolic acid and other chemical components, and has the functions of resisting pathogenic microorganisms, resisting poison, resisting inflammation, relieving fever, and promoting phagocytosis of inflammatory cells. It is used as the main drug in the invention.

[0020] Viola yedoensis, bitter, pungent, cold. Entrance to the heart and lung meridians. Has the effects of clearing away heat and detoxifying, cooling blood and relieving swelling, clearing heat and removing dampness, and is used as an adjuvant in the present invention.

[0021] Taraxacum mongolicum is sweet, slightly bitter and cold in nature. It enters the liver and stomach meridians. It has anti-inflammatory and antibacterial effects. It is used as an adjuvant in the present invention. Folium isatidis has anti-inflammatory, antibacterial and detumescent effects and is used as an adjuvant in the present invention.

[0022] Phellodendron chinense has the effects of anti-inflammatory, detoxification and sore treatment.

[0023] Sophora flavescens has anti-inflammatory, antibacterial and anti-tumor effects. It can also promote the growth and repair of damaged vascular nerve cells, which is beneficial to the repair of oral wounds.

[0024] Scutellaria baicalensis has excellent anti-inflammatory effects. When used together with Sophora flavescens and Phellodendron chinense, it has excellent anti-inflammatory and antibacterial effects.

[0025] Mint freshens breath and also has anti-inflammatory and analgesic effects.

[0026] The oral care composition and preparation method of the present invention have the following beneficial effects:

[0027] 1. The present invention adopts a specific proportion of Chinese herbal extracts, which can inhibit oral bacteria, clear breath, and effectively prevent the occurrence of oral cancer in daily care. When severe stomatitis, oral mucosal congestion, edema and other diseases occur in the oral cavity, it can relieve pain and inflammation, quickly reduce swelling, and effectively treat.

[0028] 2. The Chinese medicine extract used in the present invention will not cause any harm to the human body after being accidentally swallowed, and is safe and reliable. DETAILED DESCRIPTION

[0029] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Example 1

[0031] A Chinese medicine extract for an oral care composition comprises the following components in parts by weight: 30 parts of honeysuckle, 10 parts of Viola yedoensis, 10 parts of dandelions, 10 parts of isatis indigotica, 2 parts of phellodendron, 2 parts of sophora flavescens, 2 parts of scutellaria baicalensis, and 5 parts of mint.

[0032] The preparation method of the Chinese medicine extract of this embodiment comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, Phellodendron chinense, Sophora flavescens, Scutellaria baicalensis and mint into water with a solid-liquid ratio of 1:10, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3 times, combining the filtrates to obtain the Chinese medicine extract of the present invention.

[0033] Example 2

[0034] A Chinese medicine extract for an oral care composition comprises the following components in parts by weight: 50 parts of honeysuckle, 30 parts of Viola yedoensis, 30 parts of dandelion, 30 parts of isatis indigotica, 5 parts of phellodendron, 5 parts of sophora flavescens, 5 parts of scutellaria baicalensis, and 20 parts of mint.

[0035] The preparation method of the Chinese medicine extract of this embodiment comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, Phellodendron chinense, Sophora flavescens, Scutellaria baicalensis and mint into water with a solid-liquid ratio of 1:20, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3 times, combining the filtrates, and obtaining the Chinese medicine extract of the present invention.

[0036] Example 3

[0037] A Chinese medicine extract for an oral care composition comprises the following components in parts by weight: 40 parts of honeysuckle, 20 parts of Viola yedoensis, 20 parts of dandelions, 20 parts of isatis indigotica, 8 parts of phellodendron, 8 parts of sophora flavescens, 8 parts of scutellaria baicalensis, and 10 parts of mint.

[0038] The preparation method of the Chinese medicine extract of this embodiment comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, Phellodendron chinense, Sophora flavescens, Scutellaria baicalensis and mint into water with a solid-liquid ratio of 1:15, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3 times, combining the filtrates, and obtaining the Chinese medicine extract of the present invention.

[0039] Example 4

[0040] A Chinese medicine extract for an oral care composition comprises the following components in parts by weight: 50 parts of honeysuckle, 30 parts of Viola yedoensis, 15 parts of dandelions, 30 parts of isatis indigotica, 5 parts of phellodendron, 5 parts of sophora flavescens, 5 parts of scutellaria baicalensis, and 10 parts of mint.

[0041] The preparation method of the Chinese medicine extract of this embodiment comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, Phellodendron chinense, Sophora flavescens, Scutellaria baicalensis and mint into water with a solid-liquid ratio of 1:15, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3 times, combining the filtrates, and obtaining the Chinese medicine extract of the present invention.

[0042] Example 5

[0043] An oral care liquid comprises the following components, calculated in 100 parts by weight: 50 parts of the traditional Chinese medicine extract obtained in Example 1, 1 part of poloxamer 407, 10 parts of sorbitol, 0.1 part of potassium sorbate, and the balance is water.

[0044] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese medicine extract by 1 times, adding poloxamer 407, sorbitol, potassium sorbate and water, mixing evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0045] Example 6

[0046] An oral care liquid comprises the following components, based on 100 parts by weight: 80 parts of the traditional Chinese medicine extract obtained in Example 2, 1 part of poloxamer 407, 10 parts of sorbitol, 0.1 part of potassium sorbate, and the balance is water.

[0047] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese herbal medicine extract 100 times, adding poloxamer 407, sorbitol, potassium sorbate and water to mix evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0048] Example 7

[0049] An oral care liquid comprises the following components, based on 100 parts by weight: 80 parts of the traditional Chinese medicine extract obtained in Example 2, 1 part of decanyl betaine, 10 parts of sorbitol, 0.1 parts of potassium sorbate, 5 parts of propylene glycol, and the balance is water.

[0050] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese medicine extract by 10 times, adding decyl betaine, sorbitol, potassium sorbate, propylene glycol and water, mixing evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0051] Example 8

[0052] An oral care liquid comprises the following components, based on 100 parts by weight: 60 parts of the traditional Chinese medicine extract obtained in Example 3, 1 part of dodecyl betaine, 10 parts of sorbitol, 0.1 parts of potassium sorbate, 5 parts of propylene glycol, and the balance is water.

[0053] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese medicine extract by 10 times, adding dodecyl betaine, sorbitol, potassium sorbate, propylene glycol and water, mixing evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0054] Example 9

[0055] An oral care liquid comprises the following components, based on 100 parts by weight: 80 parts of the traditional Chinese medicine extract obtained in Example 4, 1 part of tetradecyl betaine, 10 parts of sorbitol, 0.1 parts of potassium sorbate, 5 parts of polyethylene glycol, and the balance is water.

[0056] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese medicine extract by 10 times, adding dodecyl betaine, sorbitol, potassium sorbate, polyethylene glycol and water, mixing evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0057] Example 10

[0058] An oral care liquid comprises the following components, based on 100 parts by weight: 50 parts of the traditional Chinese medicine extract obtained in Example 4, 0.5 parts of cetyl betaine, 5 parts of sorbitol, 0.1 parts of potassium sorbate, 3 parts of polyethylene glycol, and the balance is water.

[0059] The preparation method of the oral care composition of this embodiment includes: diluting the Chinese medicine extract by 5 times, adding hexadecyl betaine, sorbitol, potassium sorbate, polyethylene glycol and water, mixing evenly, and then ultrafine filtering to remove impurities to obtain an oral care solution.

[0060] Test and Inspection

[0061] 1. Detection of the effect of the present invention on oral ulcers

[0062] The mice were divided into 8 groups, and the experimental group, blank group and control group were set respectively. Three mice in each group were tested in parallel. The experimental groups were respectively administered with the oral care solutions obtained in Examples 5-10, the blank group was not administered, the control group 1 was administered with normal saline, and the control group 2 was administered with chlorhexidine gargle.

[0063] Rat ulcer model establishment: Take a 2.5 mm × 2.5 mm filter paper and soak it in 50% acetic acid. Place the soaked filter paper on the labial mucosa area of ​​the lower incisor of different mice for 30 seconds.

[0064] The drug administration started on the second day after modeling. Take a gauze of appropriate size and soak it in the oral care solution of the present invention. Control group 1 uses normal saline, and control group 2 uses chlorhexidine gargle. After the rats are anesthetized, the soaked gauze is covered on the ulcer for 5 minutes, then removed and rinsed with normal saline. The drug was administered for 5 days and the ulcer healing status was recorded. The results are shown in Table 1;

[0065] Table 1 Ulcer healing

[0066]

[0067] As can be seen from Table 1, the blank group did not undergo any treatment, and it showed a trend of first rising and then falling. The control group had certain bactericidal and antibacterial effects due to the use of cleaning saline and chlorhexidine, so the ulcer area was gradually reduced. The nursing solution of the present invention and the control group 2 both had a smaller range of reduction in 1-2 days, but in the present invention on the 3rd day, the ulcer healed on a large area, and was basically completely healed on the 5th day; and the control group 2 still showed a uniform reduction, indicating that the present invention has a significant and rapid effect on the treatment of oral ulcers.

[0068] 2. Antibacterial Test

[0069] The test bacteria and fungi in the logarithmic growth phase were diluted 100 times, respectively, and treated with the care solution obtained in Examples 5-10 of the present invention for 3 minutes, and the antibacterial rates were compared.

[0070] Antibacterial rate = (P0-P1) / P0×100%;

[0071] P0: initial colony count;

[0072] P1: colony count at the end;

[0073] The results obtained are shown in Table 2;

[0074] Table 2 3min inhibition rate

[0075]

[0076] It can be seen from Table 2 that the present invention can achieve an inhibition rate of 99.99% against conventional bacteria, and has a bactericidal effect of more than 97% against fungi.

[0077] 3. Treatment effect on oral patients

[0078] A total of 140 patients with recurrent oral ulcers were selected, including 70 males and 70 females, aged between 15 and 65 years old. The patients were randomly divided into 7 groups, with 20 cases in each group.

[0079] Inclusion criteria: Patients have ulcers on the mucosa of the lips, soft palate or gums. The ulcer surface is round or oval, sunken, with a white or yellow center, congestion, slight redness and swelling around it, and obvious pain.

[0080] Method: Each group was given the oral care solution of Examples 5-10, and the control group was given chlorhexidine gargle water, two to three times a day, about 30 ml each time, for 21 days, and the efficacy was evaluated respectively;

[0081] Efficacy evaluation:

[0082] Markedly effective: local burning pain disappeared, ulcer surface healed completely, and there was no recurrence in 3 months.

[0083] Effective: There was no recurrence within 3 months of follow-up, but the interval between recurrences was prolonged, local burning pain was significantly reduced, the ulcer surface was relieved, and the number of recurrences was reduced.

[0084] Ineffective: Clinical symptoms are not relieved or even worsen.

[0085] Table 3 Treatment effects of different patients

[0086]

[0087]

[0088] As can be seen from Table 3, the oral care solution of the present invention has a good therapeutic effect on the treatment of recurrent oral diseases, can effectively reduce patients' oral ulcers, mucosal and redness and swelling, and promote the healing of oral wounds.

[0089] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present invention. The appearance of the phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0090] Finally, it should be noted that the embodiments disclosed in the present invention are only preferred embodiments of the present invention, which are only used to illustrate the technical solutions of the present invention rather than to limit them. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. An oral care composition, characterized in that: The invention at least comprises the following components: 50-80 parts of Chinese herbal medicine extract, 10-20 parts of moisturizing agent, 5-50 parts of water and 0-20 parts of auxiliary materials.

2. The oral care composition according to claim 1, characterized in that: The Chinese medicine in the Chinese medicine extract includes the following components by weight: 30-50 parts of honeysuckle, 10-30 parts of Viola yedoensis, 10-30 parts of dandelion, 10-30 parts of isatis indigotica, 1-10 parts of phellodendron, 1-10 parts of sophora flavescens, 1-10 parts of scutellaria baicalensis, and 5-20 parts of mint.

3. The oral care composition according to claim 2, characterized in that: The preparation method of the Chinese medicine extract comprises the following steps: adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, phellodendron, sophora flavescens, scutellaria baicalensis and mint into water at a solid-liquid ratio of 1:1-20, boiling for 1-2h, filtering and taking the filtrate; repeating the boiling for 3-5 times, combining the filtrate to obtain the Chinese medicine extract of the present invention.

4. The oral care composition according to claim 1, characterized in that: The moisturizing agent includes any one or more of glycerin, sorbitol, propylene glycol, xylitol, and polyethylene glycol.

5. The oral care composition according to claim 1, characterized in that: The auxiliary materials include any one or more of pharmaceutically acceptable diluents, carriers, excipients, anti-allergic agents, preservatives, adsorbents, sweeteners, and flavors.

6. The oral care composition according to claim 5, characterized in that: The preservative includes any one or more of potassium benzoate, sodium benzoate and potassium sorbate.

7. The oral care composition according to claim 1, characterized in that: The sweetener includes any one or more of sucrose, xylitol, saccharin sodium, and sorbitol.

8. The oral care composition according to claim 1, characterized in that: The anti-allergic agent includes any one or more of poloxamer 407 and C10-C16 alkyl betaine.

9. The oral care composition according to any one of claims 1 to 8, characterized in that: The treatments include oral rinses, mouthwashes, breath fresheners or toothpastes or tooth paints.

10. A method for preparing the oral care composition according to any one of claims 1 to 8, characterized in that: (1) adding honeysuckle, Viola yedoensis, dandelion, isatis indigotica, phellodendron, sophora flavescens, scutellaria baicalensis and mint to water at a solid-liquid ratio of 1:1-20, boiling for 1-2 hours, filtering and taking the filtrate; repeating the boiling for 3-5 times, combining the filtrates, and sterilizing to obtain the Chinese medicine extract of the present invention; (2) After the Chinese herbal extract is cooled and diluted 1-50 times, a moisturizer, auxiliary materials and water are added and mixed thoroughly, and the mixture is filtered to obtain the oral care composition of the present invention.

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