Special diet formula capable of reducing blood glucose and preparation method of special diet formula

Abstract

The invention relates to the technical field of dietary compositions, in particular to a blood glucose reducing special diet formula and a preparation method thereof, and the blood glucose reducing special diet formula consists of the following materials in parts by weight: 30-35 parts of a modified rhizoma polygonati extract, 10-15 parts of a toona sinensis extract, 5-10 parts of a bitter gourd extract, 5-10 parts of a cinnamon extract, 5-10 parts of an astragalus membranaceus extract, 1-3 parts of chromium picolinate and 1-3 parts of alpha-lipoic acid. Original rhizoma polygonati is replaced with the modified rhizoma polygonati extract, the content of active ingredients in the modified rhizoma polygonati extract is higher, harmful substances and impurities in the rhizoma polygonati extract can be removed or reduced, the structure is easier to absorb and utilize by a human body, and a higher blood glucose reducing effect is achieved; through the synergistic effect of the modified rhizoma polygonati extract, the cedrela sinensis extract, the bitter gourd extract, the cinnamon extract, the radix astragali extract, the chromium picolinate and the alpha-lipoic acid, blood glucose and lipid can be effectively reduced, and side effects on a human body are avoided.

Description

Technical Field

[0001] The invention relates to the technical field of dietary compositions, in particular to a special dietary formula for reducing blood sugar and a preparation method thereof. Background Art

[0002] Diabetes mellitus is a group of clinical syndromes caused by the interaction of genetic and environmental factors. The prevalence of diabetes mellitus is very large in the world, and there is no very good method for its treatment.

[0003] Currently, the best way to avoid and control diabetic complications is to control blood sugar levels. Measures to lower blood sugar mainly include inhibiting starch and glucose absorption, promoting insulin secretion and directly supplementing insulin.

[0004] The drugs commonly used in clinical practice to lower blood sugar are mainly Western medicines. Although the therapeutic effects are significant, they all have toxic side effects and adverse reactions to varying degrees, which can damage the liver and nervous system, cause skin allergies, and life-threatening hypersensitivity reactions.

[0005] Blood sugar lowering products developed from food raw materials have a high market advantage because they have no toxic side effects. However, the edible blood sugar lowering drugs currently on the market, although non-toxic and side effects, are slow to take effect and have poor effects. Therefore, the present application proposes a special blood sugar lowering dietary formula and a preparation method thereof. Summary of the invention

[0006] The object of the present invention is to provide a special dietary formula for reducing blood sugar and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a special dietary formula for hypoglycemic, composed of the following materials by weight: 30-35 parts of modified polygonatum extract, 10-15 parts of toon extract, 5-10 parts of bitter melon extract, 5-10 parts of cinnamon extract, 5-10 parts of astragalus extract, 1-3 parts of chromium picolinate, and 1-3 parts of α-lipoic acid.

[0008] Among them, the modified Polygonatum sibiricum extract has a higher content of active ingredients and a structure that is easier to be absorbed and utilized by the human body, so it has a stronger blood sugar lowering effect. Through purification and chemical modification, the harmful substances and impurities in the Polygonatum sibiricum extract can be reduced, thereby improving the safety and purity of the product.

[0009] Toona sinensis extract contains protein, calcium ions and vitamin C, which can promote metabolism.

[0010] Bitter melon extract contains an ingredient called "momordica charantia", which has the effect of lowering blood sugar.

[0011] Active ingredients in cinnamon extract, such as hydroxychalcone polymers and methylhydroxychalcone polymers, can improve insulin resistance.

[0012] Astragalus extract contains multiple active ingredients such as polysaccharides, saponins, flavonoids, etc., which have a bidirectional regulatory effect on blood sugar.

[0013] Chromium Picolinate A form of the mineral that helps enhance the effects of insulin, thereby lowering blood sugar.

[0014] Alpha-lipoic acid is an antioxidant that helps protect pancreatic cells from oxidative stress.

[0015] Wherein, the modification steps of the modified polygonatum sibiricum extract are:

[0016] The polygonatum sibiricum extract is mixed with the mixed enzyme, the enzymolysis temperature is 45-60°C, and the enzymolysis time is 3-4 hours;

[0017] The enzymatically hydrolyzed polygonatum extract is placed in an ultrasonic device for extraction;

[0018] The polygonatum sibiricum extract after ultrasonic extraction is placed in a supercritical fluid device, and the polygonatum sibiricum extract is extracted by using the supercritical fluid as an extractant;

[0019] The polygonatum sibiricum extract after supercritical fluid extraction is mixed with a chemical modifier, and then subjected to a modification reaction at 60-80° C. for 3 hours;

[0020] The modified polygonatum extract is dried at a temperature of 70-80°C, and then the dried polygonatum extract is crushed into fine powder to obtain the modified polygonatum extract.

[0021] The mixed enzyme consists of cellulase and protease, and the combined mass ratio of the cellulase and protease is 1:1.

[0022] Wherein, the added amount of the mixed enzyme is 1-2% of the mass of the polygonatum sibiricum extract.

[0023] Wherein, the frequency of the ultrasonic wave is 30-40kHz, the power is 200-300W, and the extraction time is 40-50 minutes.

[0024] Wherein, the supercritical fluid is carbon dioxide.

[0025] Wherein, the pressure of the supercritical fluid is 20-30MPa, the temperature is 50-60°C, and the extraction time is 2-3 hours.

[0026] Wherein, the chemical modifier is one of acetic anhydride and propionic anhydride.

[0027] Wherein, the added amount of the chemical modifier is 2-4% of the mass of the polygonatum sibiricum extract.

[0028] Another aspect of the present invention provides a method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0029] Step 1, first preparing a modified polygonatum extract;

[0030] Step 2, respectively weighing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid according to weight;

[0031] Step 3, uniformly mixing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material;

[0032] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] The present invention adopts the modified polygonatum extract to replace the original polygonatum, the modified polygonatum extract has a higher content of active ingredients, can remove or reduce harmful substances and impurities in the polygonatum extract, and has a structure that is easier to be absorbed and utilized by the human body, and has a stronger hypoglycemic effect;

[0035] The present invention can effectively reduce blood sugar and lipids through the synergistic effect of modified polygonatum sibiricum extract, toona sinensis extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and alpha-lipoic acid without causing side effects on human body. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Example 1

[0038] A method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0039] Step 1: First prepare the modified polygonatum sibiricum extract. The modification steps of the modified polygonatum sibiricum extract are as follows:

[0040] The polygonatum sibiricum extract was mixed with a mixed enzyme (the mixed enzyme was composed of cellulase and protease, and the combined mass ratio of cellulase and protease was 1:1), the added amount of the mixed enzyme was 2% of the mass of the polygonatum sibiricum extract, the enzymolysis temperature was 50°C, and the enzymolysis time was 3 hours;

[0041] The enzymatically hydrolyzed polygonatum extract was placed in an ultrasonic device for extraction, the ultrasonic frequency was 35kHz, the power was 250W, and the extraction time was 45 minutes;

[0042] The polygonatum sibiricum extract after ultrasonic extraction is placed in a supercritical fluid device, and the polygonatum sibiricum extract is extracted by using a supercritical fluid (the supercritical fluid is carbon dioxide) as an extractant, the pressure of the supercritical fluid is 25 MPa, the temperature is 55° C., and the extraction time is 2 hours;

[0043] The polygonatum sibiricum extract after supercritical fluid extraction is mixed with acetic anhydride, the amount of acetic anhydride added is 3% of the mass of the polygonatum sibiricum extract, and then the modification reaction is carried out at 70° C. for 3 hours;

[0044] The modified polygonatum extract is dried at 75°C, and then the dried polygonatum extract is crushed into fine powder to obtain a modified polygonatum extract.

[0045] Step 2, weighing 30 parts of modified polygonatum extract, 10 parts of toon extract, 8 parts of bitter melon extract, 8 parts of cinnamon extract, 8 parts of astragalus extract, 2 parts of chromium picolinate, and 2 parts of α-lipoic acid respectively by weight;

[0046] Step 3, uniformly mixing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material;

[0047] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0048] Example 2

[0049] A method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0050] Step 1: First prepare the modified polygonatum sibiricum extract. The modification steps of the modified polygonatum sibiricum extract are as follows:

[0051] The polygonatum sibiricum extract was mixed with a mixed enzyme (the mixed enzyme was composed of cellulase and protease, and the combined mass ratio of cellulase and protease was 1:1), the added amount of the mixed enzyme was 2% of the mass of the polygonatum sibiricum extract, the enzymolysis temperature was 50°C, and the enzymolysis time was 3 hours;

[0052] The enzymatically hydrolyzed polygonatum extract was placed in an ultrasonic device for extraction, the ultrasonic frequency was 35kHz, the power was 250W, and the extraction time was 45 minutes;

[0053] The polygonatum sibiricum extract after ultrasonic extraction is placed in a supercritical fluid device, and the polygonatum sibiricum extract is extracted by using a supercritical fluid (the supercritical fluid is carbon dioxide) as an extractant, the pressure of the supercritical fluid is 25 MPa, the temperature is 55° C., and the extraction time is 2 hours;

[0054] The polygonatum sibiricum extract after supercritical fluid extraction is mixed with acetic anhydride, the amount of acetic anhydride added is 3% of the mass of the polygonatum sibiricum extract, and then the modification reaction is carried out at 70° C. for 3 hours;

[0055] The modified polygonatum extract is dried at 75°C, and then the dried polygonatum extract is crushed into fine powder to obtain a modified polygonatum extract.

[0056] Step 2, weighing 35 parts of modified polygonatum extract, 10 parts of toon extract, 8 parts of bitter melon extract, 8 parts of cinnamon extract, 8 parts of astragalus extract, 2 parts of chromium picolinate, and 2 parts of α-lipoic acid respectively by weight;

[0057] Step 3, uniformly mixing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material;

[0058] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0059] Example 3

[0060] A method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0061] Step 1: First prepare the modified polygonatum sibiricum extract. The modification steps of the modified polygonatum sibiricum extract are as follows:

[0062] The polygonatum sibiricum extract was mixed with a mixed enzyme (the mixed enzyme was composed of cellulase and protease, and the combined mass ratio of cellulase and protease was 1:1), the added amount of the mixed enzyme was 2% of the mass of the polygonatum sibiricum extract, the enzymolysis temperature was 50°C, and the enzymolysis time was 3 hours;

[0063] The enzymatically hydrolyzed polygonatum extract was placed in an ultrasonic device for extraction, the ultrasonic frequency was 35kHz, the power was 250W, and the extraction time was 45 minutes;

[0064] The polygonatum sibiricum extract after ultrasonic extraction is placed in a supercritical fluid device, and the polygonatum sibiricum extract is extracted by using a supercritical fluid (the supercritical fluid is carbon dioxide) as an extractant, the pressure of the supercritical fluid is 25 MPa, the temperature is 55° C., and the extraction time is 2 hours;

[0065] The polygonatum sibiricum extract after supercritical fluid extraction is mixed with acetic anhydride, the amount of acetic anhydride added is 3% of the mass of the polygonatum sibiricum extract, and then the modification reaction is carried out at 70° C. for 3 hours;

[0066] The modified polygonatum extract is dried at 75°C, and then the dried polygonatum extract is crushed into fine powder to obtain a modified polygonatum extract.

[0067] Step 2, weighing 35 parts of modified polygonatum extract, 15 parts of toon extract, 8 parts of bitter melon extract, 8 parts of cinnamon extract, 8 parts of astragalus extract, 2 parts of chromium picolinate, and 2 parts of α-lipoic acid respectively by weight;

[0068] Step 3, uniformly mixing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material;

[0069] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0070] Comparative Example 1

[0071] A method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0072] Step 1, weighing 30 parts of polygonatum extract, 10 parts of toon extract, 8 parts of bitter melon extract, 8 parts of cinnamon extract, 8 parts of astragalus extract, 2 parts of chromium picolinate, and 2 parts of α-lipoic acid respectively by weight;

[0073] Step 3, uniformly mixing the polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material;

[0074] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0075] The difference between this comparative example and Example 1 is that the modified polygonatum sibiricum extract is replaced by the polygonatum sibiricum extract, and the other components and the preparation method remain unchanged.

[0076] Comparative Example 2

[0077] A method for preparing a special dietary formula for reducing blood sugar, comprising the following steps:

[0078] Step 1, weighing 10 parts of Toona sinensis extract, 8 parts of Momordica charantia extract, 8 parts of Cinnamon bark extract, 8 parts of Astragalus membranaceus extract, 2 parts of chromium picolinate, and 2 parts of α-lipoic acid respectively by weight;

[0079] Step 3, uniformly mixing the toon extract, the bitter melon extract, the cinnamon extract, the astragalus extract, the chromium picolinate and the α-lipoic acid to obtain an initial raw material;

[0080] Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

[0081] The difference between this comparative example and Example 1 is that the modified polygonatum sibiricum extract is removed, and the other components and preparation methods remain unchanged.

[0082] Experimental example

[0083] Establishment of diabetic mouse model: 120 male mice were selected, 20 of which were reserved as the normal control group (injected with an equal volume of normal saline through the tail vein), and the remaining 100 mice were fasted for 6 hours but not water, and then injected with 60 mg / kg of alloxan through the tail vein for 7 days. All 100 mice were bred into hyperglycemic mice.

[0084] 100 hyperglycemic mice were divided into 5 groups (experimental groups 1-3 and comparison groups 1-2), with 20 mice in each group. The mice in experimental group 1 were fed 5 mg of the special blood sugar-lowering dietary formula prepared in Example 1 every day, the mice in experimental group 2 were fed 5 mg of the special blood sugar-lowering dietary formula prepared in Example 2 every day, and the mice in experimental group 3 were fed 5 mg of the special blood sugar-lowering dietary formula prepared in Example 3 every day; the mice in comparison group 1 were fed 5 mg of the special blood sugar-lowering dietary formula prepared in comparative example 1 every day; the mice in comparison group 2 were fed 5 mg of the special blood sugar-lowering dietary formula prepared in comparative example 2 every day; and the mice in the normal control group were fed 5 mg of normal saline every day.

[0085] Feeding was continued for 14 days. After the feeding was finished, blood was collected from the retroorbital venous plexus of mice in each group, and serum was separated by LD5-2 centrifuge at 3000rpm. Serum glucose was measured by Hitachi 7020 automatic biochemical analyzer. SPSS16.0 statistical software was used for statistical analysis, and one-way ANOVA was used for quantitative data. Statistical data were expressed as x±SD, and Dumiett test was used for significance test of mean between groups.

[0086] The results showed that the blood sugar level of the positive group (Xiao Ke Wan) after feeding was significantly lower than that of the model group (p<0.01), and the blood sugar level of the high-dose group (80g / kg) of hypoglycemic high dietary fiber soy milk powder after feeding was also significantly lower than that of the model group (p<0.01); the results are shown in Table 1:

[0087]

[0088]

[0089] It can be seen from the above table that after feeding the hypoglycemic special dietary formula prepared in Examples 1-3 of the present application, the blood sugar level of the mice decreased significantly. By comparing the experimental group 1 with the comparison group 1 and the comparison group 2, when the modified polygonatum extract was used instead of the polygonatum extract, the hypoglycemic effect was better; it was determined that the modified polygonatum extract had a better hypoglycemic effect.

[0090] The above-mentioned embodiments of the present invention are merely examples for clearly explaining the present invention, and are not intended to limit the embodiments of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is impossible to list all the embodiments here. Any obvious changes or modifications derived from the technical solution of the present invention are still within the scope of protection of the present invention.

Claims

1. A special dietary formula for reducing blood sugar, characterized in that: The invention is composed of the following materials by weight: 30-35 parts of modified polygonatum sibiricum extract, 10-15 parts of toon extract, 5-10 parts of bitter melon extract, 5-10 parts of cinnamon extract, 5-10 parts of astragalus extract, 1-3 parts of chromium picolinate and 1-3 parts of α-lipoic acid.

2. A special dietary formula for reducing blood sugar according to claim 1, characterized in that: The modification steps of the modified polygonatum sibiricum extract are: The polygonatum sibiricum extract is mixed with the mixed enzyme, the enzymolysis temperature is 45-60°C, and the enzymolysis time is 3-4 hours; The enzymatically hydrolyzed polygonatum extract is placed in an ultrasonic device for extraction; The polygonatum sibiricum extract after ultrasonic extraction is placed in a supercritical fluid device, and the polygonatum sibiricum extract is extracted by using the supercritical fluid as an extractant; The polygonatum sibiricum extract after supercritical fluid extraction is mixed with a chemical modifier, and then subjected to a modification reaction at 60-80° C. for 3 hours; The modified polygonatum extract is dried at a temperature of 70-80°C, and then the dried polygonatum extract is crushed into fine powder to obtain the modified polygonatum extract.

3. A special dietary formula for reducing blood sugar according to claim 2, characterized in that: The mixed enzyme consists of cellulase and protease, and the combined mass ratio of the cellulase and the protease is 1:

1.

4. A special dietary formula for reducing blood sugar according to claim 2, characterized in that: The added amount of the mixed enzyme is 1-2% of the mass of the polygonatum sibiricum extract.

5. A special dietary formula for reducing blood sugar according to claim 2, characterized in that: The frequency of the ultrasonic wave is 30-40kHz, the power is 200-300W, and the extraction time is 40-50 minutes.

6. A special dietary formula for reducing blood sugar according to claim 2, characterized in that: The supercritical fluid is carbon dioxide.

7. The special dietary formula for reducing blood sugar according to claim 2, characterized in that: The pressure of the supercritical fluid is 20-30 MPa, the temperature is 50-60° C., and the extraction time is 2-3 hours.

8. The special dietary formula for reducing blood sugar according to claim 2, characterized in that: The chemical modifier is one of acetic anhydride and propionic anhydride.

9. The special dietary formula for reducing blood sugar according to claim 2, characterized in that: The added amount of the chemical modifier is 2-4% of the mass of the polygonatum sibiricum extract.

10. The method for preparing a special dietary formula for reducing blood sugar according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1, first preparing a modified polygonatum extract; Step 2, respectively weighing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid according to weight; Step 3, uniformly mixing the modified polygonatum extract, toon extract, bitter melon extract, cinnamon extract, astragalus extract, chromium picolinate and α-lipoic acid to obtain an initial raw material; Step 4: tabletting the initial raw materials to obtain a tablet-shaped special dietary formula for reducing blood sugar.

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