Full-automatic specific protein analyzer

Abstract

The invention relates to the technical field of medical analysis, in particular to a full-automatic specific protein analyzer which comprises a shell, a sealing cover rotationally installed on the shell, a temperature raising disc rotationally installed in the shell and a sampling gun device arranged on the sealing cover. The placing assembly is rotationally mounted on the temperature raising disc; a plurality of pushing assemblies are arranged at the bottom of the placing assembly, each pushing assembly comprises a fixing ring, a plurality of extrusion rods, a plurality of pushing blocks and a plurality of extrusion blocks, the fixing rings are fixedly installed at the bottom of the placing assembly, and the extrusion rods are annularly and fixedly connected to the fixing rings through elastic pieces; the multiple pushing blocks are fixedly connected to the ends, located in the containing assembly, of the multiple extrusion rods correspondingly, and the multiple extrusion blocks are annularly and fixedly connected to the side edge of the warming disc. According to the invention, reagents and proteins are fully mixed through rotation of the instrument before detection and sampling, so that the detection efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical analysis, and in particular to a full-automatic specific protein analyzer. Background Art

[0002] The fully automatic specific protein analyzer is a medical device used to detect and analyze the concentration of specific proteins in biological fluids. By applying principles such as immunoscattering turbidimetry, it can accurately and quickly determine the concentration of a variety of specific proteins. The detection of these proteins is of great significance for the diagnosis, treatment and prognosis evaluation of a variety of diseases.

[0003] The Chinese patent with publication number CN104483499B discloses a fully automatic specific protein analyzer, which includes: a housing, a power system for providing power, a reagent cup holder for holding detection reagents, a sample turntable for holding sample cups and colorimetric cups, a sample adding needle mechanism for adding samples, a liquid path system for providing cleaning liquid and positive and negative air pressures for the sample adding needle, and a detection photoelectric system for detecting the turbidity of samples in the sample comparison cup. The above analyzer greatly improves the accuracy and detection speed of protein analysis and reduces the operating intensity of personnel.

[0004] Existing analyzers mix proteins and reagents by rotating them, but the vortex generated by the rotation cannot effectively mix the proteins and reagents quickly and evenly. If the analysis is performed after manual shaking or stirring, the efficiency of the analysis is reduced. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art that the vortex generated by rotation cannot effectively mix the protein and reagent quickly and evenly, and if the test is performed by manually shaking or stirring before shaking, the efficiency of the test is reduced. A fully automatic specific protein analyzer is proposed.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions: A fully automatic specific protein analyzer, comprising: a housing, a sealing cover rotatably mounted on the housing, an incubation tray rotatably mounted inside the housing, and a sampling gun device arranged on the sealing cover, wherein a plurality of placement components are annularly arranged on the incubation tray, and the placement components are rotatably mounted on the incubation tray and used to place sample cups; A plurality of pushing components are arranged at the bottom of the placing component, and the pushing components include a fixing ring, a plurality of extrusion rods, a plurality of pushing blocks and a plurality of extrusion blocks. The fixing ring is fixedly installed at the bottom of the placing component, and a plurality of the extrusion rods are annularly fixedly connected to the fixing ring through elastic sheets, and a plurality of the pushing blocks are respectively fixedly connected to one end of the plurality of extrusion rods located inside the placing component, and a plurality of the extrusion blocks are annularly fixedly connected to the side of the incubation tray and are used to extrude and push the extrusion rods; The placement component and the incubation tray rotate relative to each other, the extrusion rod is arranged obliquely, and one end close to the middle of the placement component is arranged obliquely upward to drive the sample cup to move obliquely upward.

[0007] Preferably, the placement assembly includes a rotating plate, two side frames and a top ring, the rotating plate is rotatably mounted on the incubation tray, the two side frames are symmetrically fixedly connected to the rotating plate, and the top ring is fixedly connected to the upper ends of the two side frames.

[0008] Preferably, a clamping assembly is provided on the top ring, and the clamping assembly is used to clamp and fix the upper end of the sample cup. The clamping assembly includes a clamping airbag ring and an extrusion airbag ring. The clamping airbag ring is fixedly installed below the top ring, and the extrusion airbag ring is installed at the upper end of the clamping airbag ring and is connected to the clamping airbag ring. The clamping airbag ring is used to clamp the side wall of the sample cup.

[0009] Preferably, a pressing assembly is provided on the bottom surface of the sealing cover, and the pressing assembly is used to press a plurality of extrusion airbag rings.

[0010] Preferably, the pressing assembly includes a rotating ring, a plurality of spring rings and a plurality of pressure plates. The rotating ring is rotatably mounted on the bottom surface of the sealing cover. The rotating ring is provided with a plurality of openings for entering the sampling gun. The plurality of spring rings are fixedly mounted on the bottom surface of the rotating ring and are respectively concentrically arranged with the plurality of openings. The plurality of pressure plates are fixedly connected to the bottom end of the spring ring for pressing and extruding the airbag ring.

[0011] Preferably, the pressure plate has a through hole in the middle, and a plurality of cleaning sheets are annularly fixedly connected inside the through hole, and the plurality of cleaning sheets are inclinedly arranged to form a cleaning ring with the middle portion downward.

[0012] Preferably, a rotating assembly is provided inside the shell, and the rotating assembly is used to drive the multiple placement assemblies to rotate when the incubation tray rotates.

[0013] Preferably, the rotating assembly includes a driving gear ring and a plurality of rotating gear rings, the driving gear ring is fixedly mounted on the inner side of the outer shell, and the plurality of rotating gear rings are respectively fixedly sleeved on a plurality of rotating plates and meshedly connected with the driving gear ring.

[0014] Preferably, a plurality of base assemblies are respectively fixedly mounted on the plurality of pushing blocks, and the base assemblies are used to push and limit the position of the clamping airbag ring.

[0015] Preferably, the bottom support assembly includes a limit bar and a support plate, the limit bar is vertically fixedly connected to the upper end of the push block, and the support plate is fixedly connected to the upper end of the limit bar and is in contact with the clamping airbag ring.

[0016] Compared with the prior art, the present invention has the following beneficial effects: The extrusion block at a fixed position will intermittently contact with multiple extrusion rods respectively, thereby pushing the end of the extrusion rod away from the extrusion block to move upward, and the extrusion rod drives the push block to move upward, and the bottom of the sample cup is tilted and pushed by the push block. After the extrusion block is separated from the extrusion rod, the sample cup falls downward due to gravity, and the intermittent contact between the extrusion block and the extrusion rod causes the sample cup to vibrate up and down and shake left and right. At the same time, the sample cup rotates, thereby accelerating the mixing of the reagent and the protein, ensuring the uniform mixing, and improving the efficiency of the test. The cup will shake, and rigid placement will cause wear on the upper end of the sample cup. The elastic clamping airbag ring can be deformed along with the sample cup, thereby preventing the sample cup from being worn when shaking. When the sealing cover is closed, the extrusion airbag ring will be squeezed, so that the gas inside the extrusion airbag ring is squeezed into the clamping airbag ring, causing the clamping airbag ring to expand toward the middle, thereby elastically clamping and limiting the sample cup, ensuring that the sample cup slides up and down and shakes left and right. The upper end opening of the sample cup is blocked by a pressure plate to prevent the solution inside the sample cup from splashing during shaking. In the process of sample cup rotation, the rotating ring will rotate with the sample cup, and the spring ring can deflect freely, ensuring the close contact between the pressure plate and the sample cup during the shaking of the sample cup; because the sampling gun device will adhere to the outside during the sampling process after cleaning, the cleaning ring will scrape the cleaning liquid when the sampling gun device passes through the cleaning ring, thereby preventing the cleaning liquid from entering the sample cup and affecting the test results, thereby improving the accuracy of the test; in the process of rotation of the placement component, the meshing rotation of the rotating gear and the driving gear can simultaneously drive The multiple placement components rotate, thereby rotating the solution in the sample cup inside the placement component, mixing the reagent and protein. The fully mixed solution can improve the accuracy of the detection; when the extrusion rod slides under the pushing action of the extrusion block, it will drive the limit bar to move upward, thereby contacting and extruding the clamping airbag ring through the support plate, so that the clamping airbag ring bulges to the other side of the squeeze. Since the direction of the bulge is consistent with the direction of the extrusion rod below, the direction of the sample cup being pushed up and down is consistent, thereby ensuring the shaking amplitude of the sample cup and ensuring the full mixing of the reagent and protein. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 This is a schematic diagram of the side structure of a fully automatic specific protein analyzer proposed by the present invention; Figure 2 This is a schematic diagram of the structure of a sampling gun device of a fully automatic specific protein analyzer proposed by the present invention; Figure 3 This is a schematic diagram of the internal structure of a fully automatic specific protein analyzer proposed by the present invention; Figure 4This is a schematic cross-sectional view of a fully automatic specific protein analyzer proposed by the present invention; Figure 5 This is a schematic diagram of the structure of the placement components of a fully automatic specific protein analyzer proposed by the present invention; Figure 6 This is a schematic cross-sectional view of the placement components of a fully automatic specific protein analyzer proposed by the present invention; Figure 7 This is a schematic diagram of the structure of a driving component of a fully automatic specific protein analyzer proposed by the present invention; Figure 8 This is a schematic diagram of the structure of a pressing component of a fully automatic specific protein analyzer proposed by the present invention; Fig. 9 This is a schematic diagram of the structure of a rotating component of a fully automatic specific protein analyzer proposed by the present invention.

[0017] In the figure: 1. shell; 2. incubation plate; 3. placement assembly; 31. rotating plate; 32. side frame; 33. top ring; 4. pushing assembly; 41. fixing ring; 42. extrusion rod; 43. pushing block; 44. extrusion block; 5. clamping assembly; 51. clamping airbag ring; 52. extrusion airbag ring; 6. pressing assembly; 61. rotating ring; 62. spring ring; 63. pressure plate; 7. rotating assembly; 71. driving gear ring; 72. rotating gear ring; 8. bottom support assembly; 81. limit strip; 82. support plate; 9. cleaning sheet; 10. sealing cover; 11. sampling gun device. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0019] The terms such as "upper", "lower", "left", "right", "middle" and "one" used in the present invention are only for the convenience of description and are not used to limit the scope of the present invention. Changes or adjustments to their relative relationships should be regarded as the scope of the present invention without substantially changing the technical content.

[0020] Reference Figure 1-Figure 9 A fully automatic specific protein analyzer, comprising: a housing 1, a sealing cover 10 rotatably mounted on the housing 1, an incubation tray 2 rotatably mounted inside the housing 1, and a sampling gun device 11 arranged on the sealing cover 10, wherein a plurality of placement components 3 are annularly arranged on the incubation tray 2, and the placement components 3 are rotatably mounted on the incubation tray 2 and are used to place sample cups; A plurality of pushing components 4 are arranged at the bottom of the placing component 3, and the pushing components 4 include a fixing ring 41, a plurality of extrusion rods 42, a plurality of pushing blocks 43 and a plurality of extrusion blocks 44. The fixing ring 41 is fixedly installed at the bottom of the placing component 3, and the plurality of extrusion rods 42 are annularly fixedly connected to the fixing ring 41 through elastic sheets, and the plurality of pushing blocks 43 are respectively fixedly connected to one end of the plurality of extrusion rods 42 located inside the placing component 3, and the plurality of extrusion blocks 44 are annularly fixedly connected to the side of the incubation tray 2, and are used to extrude and push the extrusion rods 42; The placement component 3 and the incubation tray 2 rotate relative to each other, the squeezing rod 42 is tilted, and one end close to the middle of the placement component 3 is tilted upward to drive the sample cup to move tilted upward.

[0021] In the embodiment of the application of the above technical solution, after the sample cup containing the protein is placed inside the placement component 3, the incubation tray 2 starts to rotate. During the rotation process, the extrusion blocks 44 at the fixed positions will intermittently contact the multiple extrusion rods 42 respectively, thereby pushing the end of the extrusion rod 42 away from the extrusion block 44 to move upward, and the extrusion rod 42 drives the push block 43 to move upward, and the bottom of the sample cup is tilted and pushed by the push block 43. After the extrusion block 44 separates from the extrusion rod 42, the sample cup falls downward due to gravity, and the intermittent contact between the extrusion block 44 and the extrusion rod 42 causes the sample cup to vibrate up and down and shake left and right. At the same time, the sample cup rotates, thereby accelerating the mixing of the reagent and the protein, ensuring the uniformity of the mixing, and improving the efficiency of the detection.

[0022] After the mixing is completed, the mixed liquid is extracted and tested through the sampling gun device 11, thereby completing the analysis of the protein.

[0023] The invention fully mixes the reagent and the protein by rotating the instrument itself before testing and sampling, thereby improving the testing efficiency.

[0024] The preferred technical solution in this embodiment is: Reference Figure 4-7 The placement assembly 3 includes a rotating plate 31, two side frames 32 and a top ring 33. The rotating plate 31 is rotatably mounted on the incubation tray 2. The two side frames 32 are symmetrically fixedly connected to the rotating plate 31. The top ring 33 is fixedly connected to the upper ends of the two side frames 32. The top ring 33 is provided with a clamping assembly 5, which is used to clamp and fix the upper end of the sample cup. The clamping assembly 5 includes a clamping airbag ring 51 and an extrusion airbag ring 52. The clamping airbag ring 51 is fixedly installed below the top ring 33, and the extrusion airbag ring 52 is installed at the upper end of the clamping airbag ring 51 and is connected to the clamping airbag ring 51. The clamping airbag ring 51 is used to clamp the side wall of the sample cup.

[0025] Through the placement rack with a large amount of space on the side, the heat inside the shell can directly contact the side wall of the sample cup over a large area, thereby improving the heat absorption of the sample cup during the insulation and heating process and reducing heat waste. At the same time, sufficient deflection space is provided for the sample cup to shake, avoiding impact when the sample cup shakes.

[0026] Since the sample cup will shake during the analysis and detection process, rigid placement will cause wear on the upper end of the sample cup. By providing an elastic clamping airbag ring 51, it can deform along with the sample cup, thereby avoiding wear on the sample cup when shaking.

[0027] When placing the sample cup, the sample cup is clamped and limited by the clamping airbag ring 51 that moves toward the middle from the bottom. When the sealing cover 10 is closed, the squeezing airbag ring 52 is squeezed, so that the gas inside the squeezing airbag ring 52 is squeezed into the clamping airbag ring 51, causing the clamping airbag ring 51 to expand toward the middle, thereby elastically clamping and limiting the sample cup, ensuring that the sample cup can slide up and down and shake left and right.

[0028] Reference Figure 8 The bottom surface of the sealing cover 10 is provided with a pressing assembly 6, and the pressing assembly 6 is used to press a plurality of extrusion airbag rings 52; The pressing assembly 6 includes a rotating ring 61, a plurality of spring rings 62 and a plurality of pressure plates 63. The rotating ring 61 is rotatably mounted on the bottom surface of the sealing cover 10. The rotating ring 61 is provided with a plurality of openings for entering the sampling gun. The plurality of spring rings 62 are fixedly mounted on the bottom surface of the rotating ring 61 and are respectively concentrically arranged with the plurality of openings. The plurality of pressure plates 63 are fixedly connected to the bottom end of the spring ring 62 and are used to press and squeeze the airbag ring 52. The pressing plate 63 has a through hole in the middle, and a plurality of cleaning sheets 9 are annularly fixedly connected inside the through hole. The plurality of cleaning sheets 9 are tilted to form a cleaning ring with the middle portion downward, and the cleaning sheets 9 are made of elastic material.

[0029] Since the sealing cover 10 is provided with a sampling port for introducing the sampling gun device 11, in order to reduce the entry of external bacteria into the analyzer, the sampling port position is blocked by the rotating ring 61, and the opening is sealed by the cleaning ring. When sampling is not performed, the sampling port is sealed.

[0030] Since the positions of the pressing component 6 and the placing component 3 correspond, after the sample cup is placed inside the placing component 3, the sealing cover 10 is closed to make the pressing plate 63 of the pressing component 6 contact and squeeze the squeezing airbag ring 52, thereby completing the clamping and fixing of the sample cup. At the same time, the upper opening of the sample cup is blocked by the pressing plate 63 to prevent the solution inside the sample cup from splashing out during shaking. During the rotation of the sample cup, the rotating ring 61 will rotate with the sample cup, and the spring ring 62 can deflect freely, thereby ensuring that the pressing plate 63 is in close contact with the sample cup during the shaking of the sample cup.

[0031] Since the sampling gun device 11 has cleaning liquid adhering to the outside during the sampling process, the cleaning ring will scrape off the cleaning liquid when the sampling gun device 11 passes through the cleaning ring, thereby preventing the cleaning liquid from entering the sample cup and affecting the test results, thereby improving the accuracy of the test.

[0032] Reference Fig. 9 A rotating assembly 7 is disposed inside the housing 1, and the rotating assembly 7 is used to drive the multiple placement assemblies 3 to rotate when the incubation tray 2 rotates; The rotating assembly 7 includes a driving gear ring 71 and a plurality of rotating gear rings 72 . The driving gear ring 71 is fixedly mounted on the inner side of the housing 1 . The plurality of rotating gear rings 72 are respectively fixedly sleeved on a plurality of rotating plates 31 and meshedly connected with the driving gear ring 71 .

[0033] During the solution mixing stage, the incubation tray 2 is driven by a motor to rotate. During the rotation, the incubation tray 2 drives multiple placement components 3 to rotate. During the rotation, the placement components 3 can simultaneously drive multiple placement components 3 to rotate through the meshing rotation of the rotating gear ring 72 and the driving gear ring 71, thereby causing the solution in the sample cup inside the placement component 3 to rotate, so that the reagent and protein are mixed. The fully mixed solution can improve the accuracy of the detection.

[0034] By using a simple structure to drive multiple sample cups to rotate and mix simultaneously, not only the structure is optimized, but also it is convenient to control the speed of simultaneous rotation of multiple sample cups. The rotation speed of the incubation plate 2 can be used to control the rotation and shaking speed of the sample cups.

[0035] Reference Fig. 9 A plurality of bottom bracket assemblies 8 are respectively fixedly mounted on the plurality of pushing blocks 43, and the bottom bracket assemblies 8 are used to push and limit the position of the clamping airbag ring 51; The bottom support assembly 8 includes a limit bar 81 and a support plate 82 . The limit bar 81 is vertically fixedly connected to the upper end of the push block 43 . The support plate 82 is fixedly connected to the upper end of the limit bar 81 and is in contact with the clamping airbag ring 51 .

[0036] During the deformation of the clamping airbag ring 51, the bottom surface of the clamping airbag ring 51 is supported and blocked by the multiple supporting plates 82 below, so that the clamping airbag ring 51 will expand toward the middle when deforming, thereby ensuring effective clamping of the sample cup.

[0037] When the squeezing rod 42 slides under the push of the squeezing block 44, it will drive the limit bar 81 to move upward, thereby contacting and squeezing the clamping airbag ring 51 through the support plate 82, so that the clamping airbag ring 51 bulges to the other side of the squeeze. Since the direction of the bulge is consistent with the direction of push of the squeezing rod 42 below, the direction of the sample cup being pushed up and down is consistent, thereby ensuring the shaking amplitude of the sample cup and ensuring sufficient mixing of the reagent and protein.

[0038] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A fully automatic specific protein analyzer, comprising: A housing (1), a sealing cover (10) rotatably mounted on the housing (1), an incubation tray (2) rotatably mounted inside the housing (1), and a sampling gun device (11) disposed on the sealing cover (10), characterized in that a plurality of placement components (3) are annularly disposed on the incubation tray (2), and the placement components (3) are rotatably mounted on the incubation tray (2) and are used to place sample cups; A plurality of pushing components (4) are arranged at the bottom of the placement component (3), and the pushing components (4) include a fixing ring (41), a plurality of extrusion rods (42), a plurality of pushing blocks (43) and a plurality of extrusion blocks (44); the fixing ring (41) is fixedly mounted at the bottom of the placement component (3); the plurality of extrusion rods (42) are annularly fixedly connected to the fixing ring (41) via elastic sheets; the plurality of pushing blocks (43) are respectively fixedly connected to one end of the plurality of extrusion rods (42) located inside the placement component (3); and the plurality of extrusion blocks (44) are annularly fixedly connected to the side of the incubation tray (2) and are used to squeeze and push the extrusion rods (42); The placement component (3) and the incubation tray (2) rotate relative to each other, the squeezing rod (42) is arranged obliquely, and one end close to the middle of the placement component (3) is arranged obliquely upward, so as to drive the sample cup to move obliquely upward.

2. A fully automatic specific protein analyzer according to claim 1, characterized in that: The placement assembly (3) comprises a rotating plate (31), two side frames (32) and a top ring (33); the rotating plate (31) is rotatably mounted on the incubation tray (2); the two side frames (32) are symmetrically fixedly connected to the rotating plate (31); and the top ring (33) is fixedly connected to the upper ends of the two side frames (32).

3. A fully automatic specific protein analyzer according to claim 2, characterized in that: A clamping assembly (5) is provided on the top ring (33), and the clamping assembly (5) is used to clamp and fix the upper end of the sample cup. The clamping assembly (5) comprises a clamping airbag ring (51) and an extrusion airbag ring (52). The clamping airbag ring (51) is fixedly mounted below the top ring (33), and the extrusion airbag ring (52) is mounted on the upper end of the clamping airbag ring (51) and is in communication with the clamping airbag ring (51). The clamping airbag ring (51) is used to clamp the side wall of the sample cup.

4. A fully automatic specific protein analyzer according to claim 3, characterized in that: A pressing assembly (6) is provided on the bottom surface of the sealing cover (10), and the pressing assembly (6) is used to press a plurality of extrusion airbag rings (52).

5. A fully automatic specific protein analyzer according to claim 4, characterized in that: The pressing assembly (6) comprises a rotating ring (61), a plurality of spring rings (62) and a plurality of pressure plates (63); the rotating ring (61) is rotatably mounted on the bottom surface of the sealing cover (10); a plurality of openings for entering the sampling gun are provided on the rotating ring (61); the plurality of spring rings (62) are fixedly mounted on the bottom surface of the rotating ring (61) and are respectively arranged concentrically with the plurality of openings; the plurality of pressure plates (63) are fixedly connected to the bottom end of the spring ring (62) and are used to press the extrusion airbag ring (52).

6. A fully automatic specific protein analyzer according to claim 5, characterized in that: The pressing plate (63) has a through hole in the middle, and a plurality of cleaning sheets (9) are annularly fixedly connected inside the through hole. The plurality of cleaning sheets (9) are arranged at an angle to form a cleaning ring with the middle portion facing downward.

7. A fully automatic specific protein analyzer according to claim 1, characterized in that: A rotating assembly (7) is arranged inside the housing (1), and the rotating assembly (7) is used to drive the plurality of placement assemblies (3) to rotate when the incubation tray (2) rotates.

8. A fully automatic specific protein analyzer according to claim 7, characterized in that: The rotating assembly (7) comprises a driving gear ring (71) and a plurality of rotating gear rings (72); the driving gear ring (71) is fixedly mounted on the inner side of the housing (1); the plurality of rotating gear rings (72) are respectively fixedly sleeved on a plurality of rotating plates (31) and meshedly connected with the driving gear ring (71).

9. A fully automatic specific protein analyzer according to claim 1, characterized in that: A plurality of bottom bracket assemblies (8) are respectively fixedly mounted on the plurality of pushing blocks (43), and the bottom bracket assemblies (8) are used to push and limit the position of the clamping airbag ring (51).

10. A fully automatic specific protein analyzer according to claim 9, characterized in that: The bottom support assembly (8) comprises a limit bar (81) and a support plate (82), wherein the limit bar (81) is vertically fixedly connected to the upper end of the push block (43), and the support plate (82) is fixedly connected to the upper end of the limit bar (81) and is in contact with the clamping airbag ring (51).

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