Intravascular stent

Abstract

The invention relates to an intravascular stent which is characterized in that a first stent section is made of a non-degradable material and is provided with two first axial end parts, a second stent section is made of a degradable material and is provided with two second axial end parts, and the first axial end parts and the second axial end parts are made of a degradable material. A first axial end of the first stent section is connected to a second axial end of the second stent section by a stent connection section. The first stent section is made of a non-degradable material, the second stent section is made of a degradable material, the first stent section can stay in a blood vessel for a long time compared with the second stent section, and the first stent section is used for providing a long-time supporting force at a narrow lesion position and exerting the excellent supporting performance of the first stent section; the second stent section is used for providing supporting force in a short time to ensure that the lumen is smooth before endothelialization of the intravascular stent, and the second stent section can be naturally degraded in the later period, so that metal implantation is reduced, and the fracture rate of the intravascular stent is reduced.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to vascular stents. Background Art

[0002] Lower limb arterial disease mainly presents with vascular stenosis and vascular obstruction. Interventional treatments for lower limb arterial disease include balloon angioplasty and vascular stent implantation. With the development of intravascular technology, the use of stents in interventional treatment has been widely recognized.

[0003] The peripheral stent products used in interventional treatment are gradually enriched. In addition to the mainstream bare stents, more effective and distinctive products such as absorbable stents, covered stents, drug-eluting stents and spot stents are also gradually developing. For example, absorbable stents are expected to be completely degraded after implantation, and will not cause excessive vascular load after degradation. Compared with other types of stent designs, spot stents have advantages such as lower metal load, lower chronic outward expansion force, less vascular stimulation, and lower stent rupture rate.

[0004] For peripheral lesions, calcification and occlusion are usually severe, and the lesions are relatively long. According to the characteristics of such lesions, it is necessary to implant a long-segment stent with higher support force. However, the long length of the stent is prone to stent breakage due to metal fatigue, which eventually triggers an inflammatory response and intimal hyperplasia, causing restenosis in the stent. There is evidence that due to its higher breakage rate, the risk of loss of patency and revascularization of longer stents is twice that of ordinary stents (such as point stents).

[0005] Therefore, with regard to peripheral lesions, although the existing various types of stents have their own characteristics, none of them can meet the needs of peripheral lesions. It is difficult for surgeons to make a choice between the supporting effect and the subsequent risks, which makes it impossible for peripheral lesions to be effectively treated. Summary of the invention

[0006] Based on this, it is necessary to provide a vascular stent to address the above-mentioned technical problems.

[0007] The present application provides a vascular stent, the vascular stent comprising:

[0008] A first stent section, wherein the material of the first stent section is a non-degradable material and the first stent section has two first axial ends;

[0009] A second stent segment, wherein the material of the second stent segment is a degradable material, and the second stent segment has two second axial ends;

[0010] A support connecting section, a first axial end of the first support section is connected to a second axial end of the second support section via the support connecting section.

[0011] In one embodiment, the support connection section includes a plurality of support connection unit sections, and the plurality of support connection unit sections are distributed along the circumference of the first support section and the second support section, and a plurality of circumferential positions of the first axial end and the second axial end are respectively connected by the plurality of support connection unit sections.

[0012] In one embodiment, the support connecting unit segment includes a first connecting element and a second connecting element connected to each other. The material of the first connecting element is a non-degradable material and is connected to the first axial end of the first support segment. The material of the second connecting element is a degradable material and is connected to the second axial end of the second support segment.

[0013] In one embodiment, the first connecting element has a first connecting portion, the second connecting element has a second connecting portion, and the first connecting element and the second connecting element are connected via the first connecting portion and the second connecting portion; or,

[0014] The first connecting element and the second connecting element are rod-shaped connecting elements, one end of the first connecting element is connected to the first axial end of the first bracket segment, one end of the second connecting element is connected to the second axial end of the second bracket segment, and the other end of the first connecting element is connected to the other end of the second connecting element.

[0015] In one embodiment, one of the first connection portion and the second connection portion is a plug-in protrusion, and the other is a plug-in groove, and the plug-in protrusion and the plug-in groove are plugged into each other; and / or,

[0016] The first connection portion is located at an end of the first connection element, and the second connection portion is located at an end of the second connection element; and / or,

[0017] The rod-shaped connecting elements used by the first connecting element and the second connecting element are straight rod-shaped or curved rod-shaped.

[0018] In one embodiment, the first connection portion is a plug-in protrusion, the second connection portion is a plug-in groove, and the protruding surface of the plug-in protrusion has a microporous structure.

[0019] In one embodiment, the plug-in protrusion and the plug-in groove are plugged into each other and are cured in a high temperature environment, wherein the ambient temperature of the high temperature environment is between 100° and 150°, and the curing time is between 10 min and 4 h; and / or,

[0020] The microporous structure on the protrusion surface of the plug-in protrusion is obtained by at least one of anodizing, laser roughening and plasma treatment.

[0021] In one embodiment, the first support segment includes a plurality of first unit support rings, the plurality of first unit support rings are distributed along the axial direction of the first support segment, and adjacent first unit support rings are connected by a first connecting segment; and / or,

[0022] The second support segment includes a plurality of second unit support rings, the plurality of second unit support rings are distributed along the axial direction of the second support segment, and adjacent second unit support rings are connected via a second connecting segment.

[0023] In one embodiment, the first connection section includes a plurality of first connection unit segments, the plurality of first connection unit segments are distributed along the circumference of the first bracket section, and a plurality of circumferential positions of adjacent first unit bracket rings are respectively connected by the plurality of first connection unit segments; and / or,

[0024] The second connection section includes a plurality of second connection unit segments, the plurality of second connection unit segments are distributed along the circumference of the second support section, and a plurality of circumferential positions of adjacent second unit support rings are respectively connected by the plurality of second connection unit segments.

[0025] In one embodiment, the first unit support ring includes a plurality of first V-shaped frames distributed circumferentially, and the tail ends of two adjacent first V-shaped frames are connected in sequence, wherein the tip of at least a portion of the first V-shaped frames is connected to the first connecting unit segment; and / or,

[0026] The second unit support ring includes a plurality of second V-shaped frames distributed circumferentially, and the tail ends of two adjacent second V-shaped frames are connected in sequence, wherein the tip ends of at least a portion of the second V-shaped frames are connected to the second connecting unit segment.

[0027] In one embodiment, only a portion of the first V-shaped frames in adjacent first unit support rings are connected to each other through the first connecting unit segments, and the first V-shaped frames connected to each other and the first V-shaped frames not connected to each other are sequentially spaced along the circumference of the first unit support ring; and / or,

[0028] Only a portion of the second V-shaped frames in adjacent second unit support rings are connected to each other through the second connecting unit segments, and the interconnected second V-shaped frames and the unconnected second V-shaped frames are sequentially spaced along the circumference of the second unit support ring; and / or,

[0029] All first V-shaped frames of adjacent first unit support rings and all second V-shaped frames of adjacent second unit support rings in the first support section and the second support section are connected via the support connection section.

[0030] In one embodiment, the second stent segment is coated with a drug coating; and / or,

[0031] The degradable material of the second stent segment contains a drug component; and / or,

[0032] A developing component is disposed on at least one of the first bracket section, the second bracket section and the bracket connecting section; and / or,

[0033] The non-degradable material is at least one of a nickel-titanium alloy and a cobalt-chromium alloy; and / or,

[0034] The degradable material is a high molecular polymer.

[0035] In the above-mentioned vascular stent, the material of the first stent segment is non-degradable material, and the material of the second stent segment is degradable material. Therefore, the second stent segment has the function of degrading in a predetermined period of time. The first stent segment can remain in the blood vessel longer than the second stent segment. The first stent segment is mainly used to provide a longer period of support force at a narrower lesion location, that is, to exert its excellent support performance to ensure long-term patency of the lumen. The second stent segment is mainly used to provide support force in a short period of time to ensure patency of the lumen before endothelialization of the vascular stent. In the later stage, the second stent segment will naturally degrade, reducing metal placement and reducing the fracture rate of the vascular stent. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 A schematic diagram of the planar structure of a vascular stent provided in one embodiment of the present application.

[0037] Figure 2 A planar structural split diagram of a vascular stent provided in one embodiment of the present application.

[0038] Figure 3 A schematic diagram of the planar structure of a bracket connection unit segment provided in one embodiment of the present application.

[0039] Figure 4 A schematic diagram of the structure of a microporous structure provided in one embodiment of the present application.

[0040] Figure 5 A schematic diagram of the planar structure of a first connecting unit segment provided for one embodiment of the present application.

[0041] Figure Number:

[0042] 1000, first bracket section; 2000, second bracket section; 3000, bracket connection section;

[0043] 1000a, first axial end; 1100, first unit support ring; 1100a, first V-shaped frame; 1200, first connecting section; 1200a, first connecting unit section;

[0044] 2000a, second axial end; 2100, second unit support ring; 2100a, second V-shaped frame; 2200, second connecting section; 2200a, second connecting unit section;

[0045] 3100, support connection unit segment; 3100a, first connection element; 3100b, second connection element; 3100a1, first connection part; 3100b1, second connection part; 3100c1, microporous structure. DETAILED DESCRIPTION

[0046] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0047] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0048] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0049] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0050] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0051] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0052] See also Figure 1 and Figure 2 As shown, an embodiment of the present application provides a vascular stent, which includes a first stent section 1000, a second stent section 2000 and a stent connection section 3000. The material of the first stent section 1000 is a non-degradable material, the first stent section 1000 has two first axial ends 1000a, the material of the second stent section 2000 is a degradable material, the second stent section 2000 has two second axial ends 2000a, and the first axial end 1000a of the first stent section 1000 is connected to the second axial end 2000a of the second stent section 2000 through the stent connection section 3000. Among them, the non-degradable material can be nickel-titanium alloy, cobalt-chromium alloy, etc., and the degradable material can be a high molecular polymer with high yield strength, such as polycaprolactone-polylactic acid, etc.

[0053] The material of the first stent segment 1000 is a non-degradable material, so the first stent segment 1000 can be called a non-degradable stent segment, and the material of the second stent segment 2000 is a degradable material, so the second stent segment 2000 can be called a degradable stent segment, which has the function of degrading in a predetermined period. The non-degradable stent segment can stay in the blood vessel for a longer time than the degradable stent segment, so the non-degradable stent segment is mainly used to provide a longer support force at a narrower lesion location, that is, to exert its excellent support performance and ensure the long-term patency of the lumen. The degradable stent segment is mainly used to provide support force in a short time to ensure the patency of the lumen before the endothelialization of the vascular stent, and in the later stage, the degradable stent segment will naturally degrade, reducing metal placement and reducing the fracture rate of the vascular stent.

[0054] Therefore, the vascular stent provided by the present application combines the non-degradable stent segment with the degradable stent segment, so that the vascular stent of the present application has an expected fixed-point "break" at the connection between the non-degradable stent segment and the degradable stent segment, dilates the blood vessel at the location of severe lesions, effectively solves the problem of insufficient support force at severe lesions and elastic retraction of blood vessels, and at the same time, after the degradable stent segment dissolves or reabsorbs in the body (such as made of polylactic acid material), it can avoid the long-term presence of a large number of foreign bodies in the body, the breakage of metal stents, etc., reduce the metal load, and achieve long-term patency of the lumen. The non-degradable stent segment and the degradable stent segment can decompose the longer vascular stent into multiple short stents, that is, multiple non-degradable stent segments, reduce the distortion, extrusion and stretching of blood vessels, and the breakage of vascular stents caused by complex lesions.

[0055] The ratio, quantity, size, arrangement, etc. between the first stent segment 1000 and the second stent segment 2000 in the vascular stent can be individually designed according to the specific characteristics of the lesion to meet the treatment needs. Figure 1 As shown, the number of the first stent segments 1000 is two, i.e., two non-degradable stent segments, and the number of the second stent segment 2000 is one, i.e., a degradable stent segment, so that the two non-degradable stent segments are located at both ends of a degradable stent segment, and the whole constitutes a complete vascular stent, so that the vascular stent has different stent segments, i.e., non-degradable and degradable. Moreover, according to the length ratio between the first stent segment 1000 and the second stent segment 2000, and the arrangement position, the specific support position and support area when the first stent segment 1000 provides support force can also be involved.

[0056] In addition, technical personnel in this field can select the ratio, quantity, size, arrangement, etc. of the first stent segment 1000 and the second stent segment 2000 according to needs, without limitation, as long as the vascular stent can include non-degradable stent segments and degradable stent segments, and solve the problems of existing stents being unable to completely cover lesions, insufficient supporting performance, and a high breakage rate due to a large stent length that easily induces inflammatory reactions.

[0057] The first bracket section 1000 and the second bracket section 2000 are both tubular bracket structures with expansion performance, such as cylindrical structures. Therefore, the two first axial ends 1000a of the first bracket section 1000 are the two axial ends of the first bracket section 1000, and the two second axial ends 2000a of the second bracket section 2000 are the two axial ends of the second bracket section 2000. The bracket connecting section 3000 can use a variety of methods to connect the first axial end 1000a of the first bracket section 1000 and the second axial end 2000a of the second bracket section 2000, such as injection molding connection, ultrasonic welding and laser connection, etc., which are not limited to this.

[0058] See also Figures 1 to 3 As shown, in one embodiment, the support connection section 3000 includes a plurality of support connection unit sections 3100. Based on the cylindrical support structure of the first support section 1000 and the second support section 2000, the plurality of support connection unit sections 3100 can be circumferentially distributed along the circumference of the first support section 1000 and the second support section 2000, and the circumferential multiple positions of the first axial end 1000a and the second axial end 2000a are respectively connected by the plurality of circumferentially distributed support connection unit sections 3100.

[0059] Continue reading Figure 3As shown, in one embodiment, the support connection unit segment 3100 may include a first connection element 3100a and a second connection element 3100b, wherein the support connection unit segment 3100 may be made into a specific structure and shape by using processing techniques such as tube cutting, photochemical etching, electroplating, weaving, vapor deposition or 3D printing. The material of the first connecting element 3100a is a non-degradable material, and the material of the second connecting element 3100b is a degradable material, so that the support connecting unit segment 3100 is also divided into a non-degradable part and a degradable part according to the degradation characteristics of the first support segment 1000 and the second support segment 2000. The first connecting element 3100a is connected to the first axial end 1000a of the first support segment 1000, and the second connecting element 3100b is connected to the second axial end 2000a of the second support segment 2000. The first axial end 1000a and the second axial end 2000a are connected through the first connecting element 3100a and the second connecting element 3100b, and then the first support segment 1000 and the second support segment 2000 are connected through the connection between the first connecting element 3100a and the second connecting element 3100b.

[0060] The first connecting element 3100a has a first connecting portion 3100a1, and the second connecting element 3100b has a second connecting portion 3100b1. The first connecting element 3100a and the second connecting element 3100b can be connected specifically through the first connecting portion 3100a1 and the second connecting portion 3100b1. Moreover, the first connecting element 3100a and the second connecting element 3100b can be selected as rod-shaped connecting elements, one end of the first connecting element 3100a is connected to the first axial end 1000a of the first bracket segment 1000, one end of the second connecting element 3100b is connected to the second axial end 2000a of the second bracket segment 2000, and the other end of the first connecting element 3100a is connected to the other end of the second connecting element 3100b, so that the first connecting portion 3100a1 is located at the end of the first connecting element 3100a, and the second connecting portion 3100b1 is located at the end of the second connecting element 3100b. The rod-shaped connecting elements used by the first connecting element 3100a and the second connecting element 3100b may be straight rod-shaped or curved rod-shaped, for example Figure 3 As shown, the first connecting element 3100a and the second connecting element 3100b are in the shape of an arc rod bent at approximately 90°, so that the two ends of the first connecting element 3100a and the second connecting element 3100b are interconnected along the circumferential direction, thereby ensuring the roundness of the vascular stent and avoiding local breakage of the vascular stent causing stenosis and occlusion of the lumen. Of course, the first connecting element 3100a and the second connecting element 3100b can also be in the shape of an arc rod with other bending angles, which is not limited to this.

[0061] The first connection part 3100a1 and the second connection part 3100b1 can be connected in various forms. For example, in one embodiment, one of the first connection part 3100a1 and the second connection part 3100b1 is a plug-in protrusion, and the other is a plug-in groove. The plug-in protrusion and the plug-in groove are plugged into each other. In one embodiment, the first connection part 3100a1 can be a plug-in protrusion, and the second connection part 3100b1 can be a plug-in groove, and the protrusion surface of the plug-in protrusion has a microporous structure 3100c1. In addition, the first connection part 3100a1 and the second connection part 3100b1 can also be other connection structures such as an adhesive structure, a clamping structure, and a threaded connection structure. After the first connection part 3100a1 and the second connection part 3100b1 are connected to each other, other connection methods can be combined for reinforcement connection, which is not limited.

[0062] In one of the embodiments, the microporous structure 3100c1 on the protruding surface of the plug-in protrusion can be obtained by at least one micro-etching treatment method selected from anodizing, laser roughening and plasma treatment. The microporous structure 3100c1 produced by the special treatment can fully increase the bonding area, for example, fully increase the bonding area between the polymer material and the metal material. In one of the embodiments, the plug-in protrusion and the plug-in groove are respectively made of polymer material and metal material, which can improve the bonding strength between the protruding surface of the plug-in protrusion and the inner wall surface of the plug-in groove. The plug-in protrusion and the plug-in groove can be plugged into each other first, and then the plug-in protrusion and the plug-in groove are embedded in the corresponding matching mold and cured and connected in a high temperature environment, wherein the ambient temperature of the high temperature environment is between 100° and 150°, such as the ambient temperature of the high temperature environment is 100°, 105°, 110°, 115°, 120°, 125°, 130°, 135°, 140°, 145°, 150°, etc., and the processing time for the curing connection is between 10min and 4h, for example, the processing time for the curing connection is 10min, 30min, 50min, 1h, 2h, 3h, 4h, etc., and the high temperature reinforcement at the corresponding temperature can make the plug-in protrusion and the plug-in groove have a higher bonding strength.

[0063] See also Figure 1 and Figure 2As shown, in one embodiment, the first stent segment 1000 includes a plurality of first unit stent rings 1100, the plurality of first unit stent rings 1100 are distributed along the axial direction of the first stent segment 1000, and adjacent first unit stent rings 1100 are connected by a first connecting segment 1200, wherein the plurality of first unit stent rings 1100 can provide a support function after the vascular stent is released into the blood vessel. The second stent segment 2000 includes a plurality of second unit stent rings 2100, the plurality of second unit stent rings 2100 are distributed along the axial direction of the second stent segment 2000, and adjacent second unit stent rings 2100 are connected by a second connecting segment 2200, wherein the plurality of second unit stent rings 2100 can first provide a support function after the vascular stent is released into the blood vessel, and then gradually lose the support function as the degradation disappears.

[0064] Continue reading Figure 1 and Figure 2 As shown, in one embodiment, the first connection segment 1200 includes a plurality of first connection unit segments 1200a, the plurality of first connection unit segments 1200a are distributed along the circumference of the first support segment 1000, and a plurality of circumferential positions of adjacent first unit support rings 1100 are respectively connected by a plurality of first connection unit segments 1200a, and the second connection segment 2200 includes a plurality of second connection unit segments 2200a, the plurality of second connection unit segments 2200a are distributed along the circumference of the second support segment 2000, and a plurality of circumferential positions of adjacent second unit support rings 2100 are respectively connected by a plurality of second connection unit segments 2200a.

[0065] In one embodiment, the first unit support ring 1100 includes a plurality of first V-shaped frames 1100a distributed circumferentially, and the tail ends of two adjacent first V-shaped frames 1100a are connected in sequence, wherein the tip of at least a portion of the first V-shaped frames 1100a is connected to the first connecting unit segment 1200a, and the second unit support ring 2100 includes a plurality of second V-shaped frames 2100a distributed circumferentially, and the tail ends of two adjacent second V-shaped frames 2100a are connected in sequence, wherein the tip of at least a portion of the second V-shaped frames 2100a is connected to the second connecting unit segment 2200a.

[0066] In one embodiment, only a portion of the first V-shaped frames 1100a in adjacent first unit support rings 1100 are connected to each other through the first connecting unit segments 1200a, and the first V-shaped frames 1100a connected to each other and the non-connected first V-shaped frames 1100a are sequentially spaced along the circumference of the first unit support ring 1100. Sequential spacing means that a plurality of first V-shaped frames 1100a in the circumferential direction are sequentially connected in an arrangement manner of one connected and one non-connected along the circumferential direction. For details, see Figure 1As shown, according to the point that the tip on the left side formed by connecting multiple first V-shaped frames 1100a in each first unit stent ring 1100 is a wave crest, and the tip on the right side is a wave trough, it is equivalent to that only a part of the wave crests and a part of the wave troughs in adjacent first unit stent rings 1100 are connected to each other, and in the axial direction, the first connecting unit segments 1200a of all first unit stent rings 1100 are spirally distributed. Therefore, an open-loop window belonging to the first stent segment 1000 can be formed between two adjacent non-connected first V-shaped frames 1100a, and this open-loop window can improve the overall flexibility of the vascular stent.

[0067] Only a portion of the second V-shaped frames 2100a in the adjacent second unit support rings 2100 are connected to each other through the second connecting unit segments 2200a, and the second V-shaped frames 2100a connected to each other and the non-connected second V-shaped frames 2100a are sequentially spaced along the circumference of the second unit support ring 2100. Sequential spacing means that a plurality of second V-shaped frames 2100a in the circumferential direction are sequentially connected in the circumferential direction in an arrangement manner of one connected and one non-connected. For details, see Figure 1 As shown, therefore, an open-loop window belonging to the second stent segment 2000 can also be formed between two adjacent non-connected second V-shaped frames 2100a, and such an open-loop window can improve the overall flexibility of the vascular stent.

[0068] All first V-shaped frames 1100a of adjacent first unit support rings 1100 and all second V-shaped frames 2100a of second unit support rings 2100 in the first support section 1000 and the second support section 2000 are connected via the support connection section 3000, i.e., no open-loop window formed by non-connection is generated in the connection between the first support section 1000 and the second support section 2000, thereby ensuring the firmness of the connection between the first support section 1000 and the second support section 2000.

[0069] In one of the embodiments, a drug coating is applied on the second stent segment 2000, and drug ingredients are added to the degradable material of the second stent segment 2000. The applied drug coating may be a coating of drugs such as paclitaxel, rapamycin, zotarolimus, etc. The coating may be applied to a specific position or all positions on the surface of the stent, and the added drug ingredients may also be drug ingredients such as paclitaxel, rapamycin, zotarolimus, etc. Therefore, the drug may be evenly released during the gradual degradation of the second stent segment 2000, thereby playing the role of anticoagulation, antithrombosis and intimal hyperplasia.

[0070] A developing component is provided on at least one of the first stent segment 1000, the second stent segment 2000 and the stent connecting segment 3000. The developing component can be a radiopaque point or the like. The developing component can be fixed to the first stent segment 1000, the second stent segment 2000 and the stent connecting segment 3000 by riveting, sleeve joining, welding or the like. There can be multiple developing components and they can be arranged at multiple different positions of the vascular stent. For example, the developing component can be arranged at the end of the first stent segment 1000 or the first connecting segment 1200, the end of the second stent segment 2000 or the second connecting segment 2200, and the stent connecting segment 3000. The developing component can be made of a degradable material or a non-degradable material. Even if the developing component is non-degradable, it will be wrapped by the neointima after endothelialization and will not fall off the distal end. There is no limitation on this.

[0071] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0072] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A vascular stent, characterized in that: The vascular stent comprises: A first stent section, wherein the material of the first stent section is a non-degradable material and the first stent section has two first axial ends; A second stent segment, wherein the material of the second stent segment is a degradable material, and the second stent segment has two second axial ends; A support connecting section, a first axial end of the first support section is connected to a second axial end of the second support section via the support connecting section.

2. The vascular stent according to claim 1, characterized in that: The support connection section includes a plurality of support connection unit sections, and the plurality of support connection unit sections are distributed along the circumference of the first support section and the second support section, and a plurality of circumferential positions of the first axial end and the second axial end are respectively connected by the plurality of support connection unit sections.

3. The vascular stent according to claim 2, characterized in that: The support connecting unit segment includes a first connecting element and a second connecting element connected to each other. The material of the first connecting element is a non-degradable material and is connected to the first axial end of the first support segment. The material of the second connecting element is a degradable material and is connected to the second axial end of the second support segment.

4. The vascular stent according to claim 3, characterized in that: The first connecting element has a first connecting portion, the second connecting element has a second connecting portion, and the first connecting element and the second connecting element are connected via the first connecting portion and the second connecting portion; or, The first connecting element and the second connecting element are rod-shaped connecting elements, one end of the first connecting element is connected to the first axial end of the first bracket segment, one end of the second connecting element is connected to the second axial end of the second bracket segment, and the other end of the first connecting element is connected to the other end of the second connecting element.

5. The vascular stent according to claim 4, characterized in that: One of the first connection portion and the second connection portion is a plug-in protrusion, and the other is a plug-in groove, and the plug-in protrusion and the plug-in groove are plugged into each other; and / or, The first connection portion is located at an end of the first connection element, and the second connection portion is located at an end of the second connection element; and / or, The rod-shaped connecting elements used by the first connecting element and the second connecting element are straight rod-shaped or curved rod-shaped.

6. The vascular stent according to claim 5, characterized in that: The first connection portion is a plug-in protrusion, the second connection portion is a plug-in groove, and the protruding surface of the plug-in protrusion has a microporous structure.

7. The vascular stent according to claim 6, characterized in that: The plug-in protrusion and the plug-in groove are plugged into each other and are cured and connected in a high temperature environment, wherein the ambient temperature of the high temperature environment is between 100° and 150°, and the processing time of the curing connection is between 10 minutes and 4 hours; and / or, The microporous structure on the protrusion surface of the plug-in protrusion is obtained by at least one of anodizing, laser roughening and plasma treatment.

8. The vascular stent according to claim 1, characterized in that: The first support section includes a plurality of first unit support rings, the plurality of first unit support rings are distributed along the axial direction of the first support section, and adjacent first unit support rings are connected by a first connecting section; and / or, The second support segment includes a plurality of second unit support rings, the plurality of second unit support rings are distributed along the axial direction of the second support segment, and adjacent second unit support rings are connected via a second connecting segment.

9. The vascular stent according to claim 8, characterized in that: The first connection section includes a plurality of first connection unit segments, the plurality of first connection unit segments are distributed along the circumference of the first bracket section, and a plurality of circumferential positions of adjacent first unit bracket rings are respectively connected by the plurality of first connection unit segments; and / or, The second connection section includes a plurality of second connection unit segments, the plurality of second connection unit segments are distributed along the circumference of the second support section, and a plurality of circumferential positions of adjacent second unit support rings are respectively connected by the plurality of second connection unit segments.

10. The vascular stent according to claim 9, characterized in that: The first unit support ring comprises a plurality of first V-shaped frames distributed circumferentially, the tail ends of two adjacent first V-shaped frames are connected in sequence, wherein the tips of at least a portion of the first V-shaped frames are connected to the first connecting unit segment; and / or, The second unit support ring includes a plurality of second V-shaped frames distributed circumferentially, and the tail ends of two adjacent second V-shaped frames are connected in sequence, wherein the tip ends of at least a portion of the second V-shaped frames are connected to the second connecting unit segment.

11. The vascular stent according to claim 10, characterized in that: Only a portion of the first V-shaped frames in adjacent first unit support rings are connected to each other through the first connecting unit segments, and the first V-shaped frames connected to each other and the first V-shaped frames not connected to each other are sequentially spaced along the circumference of the first unit support ring; and / or, Only a portion of the second V-shaped frames in adjacent second unit support rings are connected to each other through the second connecting unit segments, and the interconnected second V-shaped frames and the unconnected second V-shaped frames are sequentially spaced along the circumference of the second unit support ring; and / or, All first V-shaped frames of adjacent first unit support rings and all second V-shaped frames of adjacent second unit support rings in the first support section and the second support section are connected via the support connection section.

12. The vascular stent according to claim 1, characterized in that: The second stent segment is coated with a drug coating; and / or, The degradable material of the second stent segment contains a drug component; and / or, A developing component is disposed on at least one of the first bracket section, the second bracket section and the bracket connecting section; and / or, The non-degradable material is at least one of a nickel-titanium alloy and a cobalt-chromium alloy; and / or, The degradable material is a high molecular polymer.

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