Composition capable of promoting hair growth and blackening of white hair and application thereof

Abstract

The invention discloses a composition capable of promoting hair growth and blackening of white hair and application of the composition. The composition comprises an active component, a composite additive and water, the active components comprise an ammonium acryloyldimethyl taurate / beheneth-25 methacrylate cross-linked polymer, fullerene, cyclodextrin, betaine, tocopheryl acetate and sodium hyaluronate. The composition which can be combined with minoxidil can play a role in synergistically enhancing the hair growth effect; the fullerene composition can repair the activity of damaged hair follicle cells, maintain the normal function of hair follicles, reconstruct microcirculation and repair scalp barriers; minoxidil can expand blood vessels and promote nutrition delivery; the combination of fullerene and fullerene can enhance the transdermal absorption of fullerene, accelerate the effect of fullerene, and accelerate and promote hair growth. Meanwhile, the side effects such as dermatitis, rash or skin irritation of minoxidil on scalp are reduced.

Description

Technical Field

[0001] The invention relates to the field of drug preparation, and in particular to a composition capable of promoting hair growth and turning white hair into black when used in combination with minoxidil, and an application thereof. Background Art

[0002] In 1985, scientists Kroto, Smalley, Curl and others discovered C while studying carbon in deep space. 60 Fullerene, for which the three won the Nobel Prize in Chemistry in 1996. Fullerene, diamond and graphite are allotropes of carbon. 60 It is a spherical molecule composed of 60 carbon atoms, composed of 12 pentagons and 20 hexagons. Each carbon atom and three adjacent carbon atoms are connected by SP 2 Hybridized bonding, called footballene because of its football-like shape.

[0003] The large π-bond conjugated system composed of multiple P orbitals of fullerene makes it have a strong ability to accept electrons. Due to its unique structure and physical and chemical properties, it has excellent free radical scavenging performance and is called a "free radical sponge". It also exhibits excellent antioxidant properties, making it widely concerned in cosmetic materials, biomedicine, etc.

[0004] Fullerene has received extensive attention in cosmetic materials, biomedicine, etc. It is an allotrope of carbon, along with diamond and graphite. Fullerene has a strong ability to accept electrons. Due to its unique structure and physical and chemical properties, it has excellent free radical scavenging properties and is called a "free radical sponge". It also exhibits excellent antioxidant properties.

[0005] Hair consists of two parts: the hair shaft and the hair root. The hair follicle is the hair tissue surrounding the root. In a normal hair follicle, the hair papilla at the bottom is connected to the capillaries in the dermis, and nutrients are transported to the hair through blood circulation. Only with sufficient nutrients can healthy hair grow, and the hair will be firm, strong and elastic.

[0006] The scalp and hair follicles are affected by the external environment and aging, which leads to an imbalance of water and oil and excessive production of free radicals, thereby damaging the function of the mitochondria of cells inside the hair follicles, causing cell aging and death, and further damaging the hair follicles, causing them to become blocked, atrophy and degenerate, causing hair to stop growing and resulting in hair loss and hair breakage.

[0007] Various scalp problems are becoming more and more serious. Scalp sensitivity, inflammation, acne, oil, hair loss and other problems are increasingly causing troubles to people's lives. Scalp and hair care are receiving more and more attention. Therefore, it is urgent to develop a multi-dimensional composition that can maintain the scalp environment, promote hair growth, prevent hair loss and strengthen hair.

[0008] Minoxidil is an ATP-sensitive potassium channel (KATP) opener. It is an effective oral antihypertensive and peripheral vasodilator that can promote vasodilation and promote hair growth.

[0009] Adverse Reactions: The most common adverse reaction in clinical practice is mild dermatitis of the scalp. Occasionally, the following adverse reactions have been reported after using this product, including irritant skin reactions (dandruff, dandruff and burning pain), nonspecific allergic reactions, rash, transient swelling, facial swelling, allergies, shortness of breath, headache, menstrual inflammation, dizziness, vertigo, vertigo, chest pain, changes in blood pressure, palpitations and changes in pulse rate.

[0010] Patent US20220062144A1 adds fullerene and minoxidil to a formula system, which requires the addition of a large amount of polyols and ethanol content, greatly reducing the stability of fullerene in the system; at the same time, when the content of polyols and ethanol is high, fullerene cannot be added to the formula to the optimal dose, which is not conducive to the efficacy; minoxidil has poor stability and is easy to precipitate, reducing the material utilization rate, and using them separately can not only increase the stability of the formula, but also enable fullerene and minoxidil to play their respective optimal effects, greatly increasing the synergistic hair growth and white-to-blackening effects of fullerene and minoxidil. Minoxidil is a medicinal raw material and cannot be directly added to cosmetics. It is extremely difficult to achieve market application in comparison with the patent.

[0011] There is an obvious incompatibility between fullerene and minoxidil in the same formula, and the active ingredients in the product will be separated out, which is very detrimental to the efficacy and storage of the product.

[0012] The therapeutic effect of minoxidil requires continuous use, and the effect will gradually disappear after discontinuation of the drug. At the same time, uncomfortable symptoms such as dry scalp and itching may also occur during use. When combined with fullerene, fullerene can effectively repair the water and oil balance of the scalp, inhibit inflammatory response, effectively reduce the side effects of minoxidil, and fullerene can grow vellus hair into terminal hair.

[0013] This patented technology does not add extra oil burden to the scalp, but achieves the use of high-concentration and effective doses of fullerene; this patented form can be used in combination with minoxidil to better repair the scalp barrier, and ultimately regulate the water and oil balance of the scalp to make the scalp healthier. Therefore, it is necessary to improve the existing technology to provide a more reliable solution. Summary of the invention

[0014] The technical problem to be solved by the present invention is to provide a fullerene composition capable of significantly promoting hair growth, a preparation method thereof and an application thereof in view of the deficiencies in the above-mentioned prior art.

[0015] In order to solve the above technical problems, the technical solution adopted by the present invention is: in a first aspect of the present invention, a composition capable of significantly promoting hair growth is provided, comprising: an active component, a composite additive and water;

[0016] Among them, the active components include ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer / ammonium acryloyldimethyl taurate / VP copolymer / ammonium acryloyldimethyl taurate / stearyl alcohol polyether methacrylate crosspolymer / hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, fullerene C60 / fullerene C70 / fullerene C60-70 mixture, cyclodextrin / methyl cyclodextrin / hydroxypropyl cyclodextrin / hydroxypropyl γ-cyclodextrin, betaine / matrine / choline / , vitamin E / tocopheryl acetate / tocopheryl linoleate / vitamin E nicotinate, acetyl tetrapeptide-3 / acetyl hexapeptide-1, sodium hyaluronate / hydrolyzed sodium hyaluronate / sodium hyaluronate crosspolymer / acetylated sodium hyaluronate.

[0017] Preferably, the composite additive comprises riboflavin, biotin, pyridoxine hydrochloride, methyl salicylate, pyrrolidino diaminopyrimidine oxide, diaminopyrimidine oxide, piperine or water-soluble azone.

[0018] Preferably, the composition capable of significantly promoting hair growth comprises, by weight percentage, 6.3-25.2% of active components, 1.4-5.6% of composite additives and the balance of water.

[0019] Preferably, the composition capable of significantly promoting hair growth comprises, by weight percentage, 1-4% of ammonium acryloyldimethyltaurate / behenyl ether-25 methacrylate crosspolymer, 0.003-0.5% of fullerene, 1-5% of hydroxypropyl cyclodextrin, 1-5% of betaine, 0.01-1% of sodium hyaluronate, 0.25-10% of tocopherol acetate; 0.02-3% of biotin, 0.02-2% of pyridoxine hydrochloride, 0.25-1% of vitamin E nicotinate or water-soluble azone, 0.5-2% of acetyl tetrapeptide-3, 0.5-2% of pyrrolidinodiaminopyrimidine oxide, and the remainder of water.

[0020] Preferably, the composition capable of significantly promoting hair growth comprises, by weight percentage, 2% of ammonium acryloyldimethyltaurate / behenylether-25 methacrylate crosspolymer, 0.11% of fullerene, 2% of hydroxypropyl cyclodextrin, 2% of betaine, 0.05% of sodium hyaluronate, 0.5% of tocopheryl acetate; 0.05% of biotin, 0.05% of pyridoxine hydrochloride, 0.5% of vitamin E nicotinate or water-soluble azone, 1% of acetyl tetrapeptide-3, 1% of pyrrolidinodiaminopyrimidine oxide, and the balance of water.

[0021] Preferably, the active ingredients include ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, fullerene C60, hydroxypropyl cyclodextrin, betaine, tocopheryl acetate, vitamin E nicotinate, acetyl tetrapeptide-3 and sodium hyaluronate.

[0022] The second aspect of the present invention provides a method for preparing the composition capable of significantly promoting hair growth as described above, comprising the following steps:

[0023] The active component, the composite solubilizer and water are mixed, stirred at 80-90° C. for 10-40 minutes, and then the composite additive and preservative are added to the obtained mixture after cooling to room temperature, and stirred evenly to obtain the composition capable of significantly promoting hair growth.

[0024] The third aspect of the present invention provides an application of the composition capable of significantly promoting hair growth as described above, which is used in combination with minoxidil to promote hair growth. The application method is: applying the composition and minoxidil to the area to be treated for hair growth in any order, or mixing the composition and minoxidil and applying them to the area to be treated for hair growth.

[0025] The fourth aspect of the present invention provides an application of the composition as described above that can significantly promote hair growth, which is used to be compounded with minoxidil to prepare a product with the function of promoting hair growth.

[0026] The beneficial effects of the present invention are:

[0027] The water-soluble composition provided by the present invention that can significantly promote hair growth has a high fullerene content, and the molecular fullerene in the system can be highly evenly dispersed; the composition provided by the present invention can be used in combination with minoxidil to synergistically enhance the hair growth effect, and at the same time has the effect of turning white hair into black hair.

[0028] Among them, the composition can repair the activity of damaged hair follicle cells, maintain the normal function of hair follicles, and rebuild microcirculation and repair scalp barriers; minoxidil can dilate blood vessels and promote nutrient delivery; minoxidil can dilate blood vessels and promote nutrient delivery; the present invention combines the two, can enhance the absorption of fullerene by the scalp, make minoxidil have better patient adaptability, promote hair growth and white to black, and can moisturize and protect the scalp, while reducing the side effects such as dermatitis, rash or skin irritation caused by minoxidil on the scalp, prolonging the efficacy of minoxidil drugs, the combination of the two can shorten the hair regeneration time, the regenerated hair roots are stable, not easy to fall off again, and inhibit the aging of hair follicle cells, maintain the activity of pigment cells, secrete pigments normally, and attach to healthy hair to achieve the effect of white to black. The product preparation method of the present invention is simple and has broad market application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is an actual effect diagram of the hair growth effect of the composition of the present invention;

[0030] Figure 2 The results of the mouse hair growth test in the present invention;

[0031] Figure 3 and Figure 4 The results of the hair growth test on mice using the hair growth composition of the present invention in combination with minoxidil;

[0032] Figure 5 This is a diagram showing the actual effect of turning white hair black by using the hair growth composition of the present invention in combination with minoxidil. DETAILED DESCRIPTION

[0033] The present invention is further described in detail below in conjunction with embodiments so that those skilled in the art can implement the invention with reference to the description.

[0034] It should be understood that the terms such as “having”, “including” and “comprising” used herein do not exclude the existence or addition of one or more other elements or combinations thereof.

[0035] The test methods used in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples are all commercially available unless otherwise specified. In the following examples, if no specific conditions are specified, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used, if the manufacturer is not specified, are all conventional products that can be purchased commercially.

[0036] Example 1

[0037] A water-soluble composition capable of significantly promoting hair growth (also referred to as a fullerene composition capable of promoting hair growth and turning white hair black) comprises: an active component, a composite additive and water. The specific formula is shown in Table 1 below:

[0038] Table 1

[0039]

[0040]

[0041] The preparation method is as follows: according to the ratio in Table 1, the active component and water are mixed, stirred at 85°C for 20 minutes, and then the composite additive and preservative are added to the mixture after cooling to room temperature, and stirred evenly to obtain a fullerene composition that can significantly promote hair growth.

[0042] Comparative Example 1

[0043] A water-soluble composition comprises: an active component, a composite additive and water, and its specific formula is shown in Table 2 below:

[0044] Table 2

[0045]

[0046]

[0047] The preparation method is the same as that in Example 1.

[0048] Comparative Example 2

[0049] A water-soluble fullerene composition comprises: an active component, a composite additive and water, and its specific formula is shown in Table 3 below:

[0050] Table 3

[0051]

[0052] The preparation method is the same as that in Example 1.

[0053] Comparative Example 3

[0054] An oil-soluble hair growth composition comprises: component A, component B and component C, and its specific formula is shown in Table 4 below:

[0055] Table 4

[0056]

[0057] Preparation method: Component A and component B are mixed, and stirred rapidly for 10 minutes, and then component C is added, and after mixing evenly, a fullerene hair growth composition is obtained.

[0058] Test Case

[0059] 1. Stability test

[0060] The following relevant performance tests were conducted using the hair growth compositions prepared in Example 1 and Comparative Examples 1-2, and the numbers are as follows:

[0061] No. 1 - Example 1;

[0062] No. 2 - Comparative Example 1;

[0063] No. 3 - Comparative Example 2.

[0064] Test Method

[0065] The obtained composition was sealed in a 100 g wide-mouth bottle for examination.

[0066] Test conditions: 45 degrees Celsius high temperature, 25 degrees Celsius room temperature, 5 degrees Celsius refrigeration, -20 degrees Celsius freezing and hot and cold cycle experiments for 30 days.

[0067] Test items: Check product properties and unchanged conditions, pH changes.

[0068] Phase: whether the product is stratified, whether there is precipitation, color change

[0069] Taste change: Whether the product smell has changed, the original product smell itself has a special smell. If it changes, it will have sour or other pungent smells.

[0070] The test results of No. 1, No. 2, and No. 3 are shown in Table 5, Table 6, and Table 7 respectively:

[0071] Table 5 Stability test results of No. 1

[0072]

[0073] Table 6 Stability test results of No. 2

[0074]

[0075]

[0076] Table 7 Stability test results of No. 3

[0077]

[0078] According to the test results, it can be concluded through 30-day observation that the product of Example 1 (No. 1) has no change in product properties, taste, or pH under each test condition. Comparative Example 1 and Comparative Example 2 have stratification.

[0079] 2. Skin feel test

[0080] The following relevant performance tests were conducted using the hair growth compositions prepared in Example 1 and Comparative Examples 1-2, and the numbers are as follows:

[0081] No. 1 - Example 1;

[0082] No. II - Comparative Example 1;

[0083] No. III—Comparative Example 2.

[0084] Test method: 20 volunteers tried the test and scored after applying the three compositions respectively after shampooing.

[0085] Test standard: The feelings of volunteers were recorded in the form of a questionnaire, with good absorption being 8-10 points, average absorption being 5-8 points, and poor absorption being 2-5 points; skin perception was excellent, relatively excellent, and average. The results are shown in Table 8.

[0086] Table 8: Skin feel test results of the composition

[0087] Sample No. Skin feel Good absorption score 8-10 points% No. I excellent 10 100 II Better 8 95 III Better 8 95

[0088] Conclusion: Product No. I has the best skin feel and the best absorbency, while No. II and No. III have better skin feel and good absorbency.

[0089] 3. Hair growth effect of fullerene composition

[0090] (1) Selection of subjects

[0091] Eligible subjects were selected according to the inclusion and exclusion criteria, and divided into the experimental group and the control group according to the random table, ensuring that the final number of effective cases was no less than 30 people / group.

[0092] (2) Selection criteria

[0093] 18-60 years old; healthy male or female; hair length between 5-40cm; those who have the problem of hair loss and mild hair thinning; those who have not had any special hair treatments such as hair dyeing, perming, styling, etc. in the past month; those who have not taken orally or used topically any drugs that affect hair growth in the past 6 months; those who have not used cosmetics with anti-hair loss effects or other products with such effects or hair growth effects in the past 3 months; those who can understand the test process, voluntarily participate in the test and sign a written informed consent; those who can promise to complete the specified contents according to the test plan, maintain the original living habits during the test, avoid emotional fluctuations, do not perform any hair care and hair treatment measures during the test, and do not accept any anti-hair loss and hair growth treatments.

[0094] (3) Experimental groups

[0095] Experimental group: using the product prepared in Example 1 as the experimental product, 30 people;

[0096] Control group: 30 people used the control product; the control product differed from Example 1 only in that the formula did not contain fullerene;

[0097] Usage: Randomly distribute experimental products and control products, and guide the subjects to use the products according to the instructions. Use once a day, after shampooing, apply 5g of the product on the scalp, and gently massage with fingertips for absorption.

[0098] Experimental period: 90 days.

[0099] (4) Test method

[0100] Conditioning the scalp environment: Use ASW scalp detection equipment to detect the scalp environment under a 60x magnification lens.

[0101] Anti-hair loss: The 60-times combing method was used. Subjects were not allowed to wash their hair within 48 hours before each visit and were not allowed to wash their hair on the morning of the visit. The technicians used a comb to comb the hair evenly 60 times in the order from the left front to the left back and from the right front to the right back, and collected and counted the number of hair loss. The hair density was observed and counted using an HD hair mirror.

[0102] (5) Experimental results

[0103] The experimental results are shown in Table 9 below:

[0104] Table 9: Hair growth results of the composition

[0105]

[0106] According to Table 9, with the cooperation of 30 volunteers in each group, the clinical test was successfully completed. The control product group without fullerene showed no effective results for 0 people, while the experimental product group containing fullerene showed an effective rate of 90% for 27 people. Figure 1 The actual effect diagram of some users is shown in the figure.

[0107] Conclusion: As can be seen from Table 3 above, the composition prepared in Example 1 has a significant effect on promoting hair growth. It can effectively reduce hair loss, control excessive oil secretion of the scalp, and regulate the scalp environment after three months of use. Molecular fullerene can improve the utilization rate of active ingredients, enhance penetration efficacy, effectively repair hair follicles, and repair capillary clusters, thereby promoting hair growth.

[0108] 4. Mouse hair growth test

[0109] Test subjects: C57BL / 6J mice, male, weighing 18-22g

[0110] Test samples: product of Example 1 (hair growth composition), product of Comparative Example 3 (oil-soluble fullerene composition), model group (testosterone solution, concentration 0.4wt%), normal group (physiological saline)

[0111] Experimental process:

[0112] After receiving the mice, they were observed for 3-7 days. The animals were kept under the conditions of 12 / 12h light alternation during the day, 40%-70% relative humidity, and 21-24℃. The hair on the back was cut short. After the mice were anesthetized, the depilatory agent was applied to the back of the mice for about 2 minutes, and then washed with warm water. The back of the mice was considered clean when it was smooth, without any injuries or residual hair. The depilatory area was about 1.5×1.5cm 2; Randomly divided into 4 groups, 5 mice in each group. After the mice were modeled, they were given drugs on the second day. Before each drug administration, the model group and the test group were first smeared with testosterone solution to cover the entire depilatory area. After the skin was dry, an appropriate amount of the test sample was evenly applied to the depilatory area; the normal group was not given drug intervention, and physiological saline was applied. The samples were the hair growth composition of the present invention and the oil-soluble fullerene composition. Each group of mice was given the drug once a day, and the drug administration was continued until the hair of the model group began to grow, and the experiment was terminated. The time for the skin of each group of mice to darken was observed, and the differences in the hair color of each test mouse were statistically analyzed.

[0113] Test results: Reference Figure 2 After 15 days of testing and observation, the hair growth of the mice in the model group was significantly affected by testosterone, and the hair failed to grow; after applying fullerene, the influence of testosterone was significantly reduced, and hair growth was effectively promoted, and the growth effect of the water-soluble system was better than that of the oil-soluble system.

[0114] 5. Hair growth test of mice using the hair growth composition combined with minoxidil

[0115] Test subjects: C57BL / 6J mice, male, weighing 18-22g

[0116] Test samples: product of Example 1, minoxidil, product of Example 1 + minoxidil, model group (testosterone solution, concentration 0.4wt%); application amount was 50ul;

[0117] Experimental process: Same as mouse hair growth test

[0118] Test results: Reference Figure 3 and Figure 4 After 15 days of testing and observation, the hair growth of mice in the model group was significantly affected by testosterone, and the hair failed to grow; applying minoxidil alone can dilate blood vessels, increase the absorption of nutrients by hair follicles, and have a weak effect on promoting hair growth. After 15 days of applying fullerene alone, the back hair was basically covered; in the combination group + minoxidil (the method of use is to apply minoxidil first, and then apply the hair growth combination), the hair of mice basically grew full, which is significantly better than the hair growth effect of a single component, indicating that the combination has a synergistic effect. Through the skin blackness value test, the gray value was the lowest after the fullerene combination was used in combination with minoxidil, which was significantly better than the model and the single-dose group.

[0119] 6. White to black test

[0120] Selection of subjects

[0121] Eligible subjects were selected according to the inclusion and exclusion criteria, and divided into the experimental group and the control group according to the random table, ensuring that the final number of effective cases was no less than 10 people / group.

[0122] Experimental Grouping

[0123] Experimental group: using the product prepared in Example 1 as the experimental product, 10 people;

[0124] Control group: 10 people used the control product; the control product differed from Example 1 only in that the formula did not contain fullerene;

[0125] How to use

[0126] The experimental product and the control product were randomly distributed, and the subjects were instructed on the use of the products according to the instructions. Use once a day, after shampooing, first apply minoxidil, wait for it to be absorbed, then apply 5g of the product to the roots of white hair on the scalp, and gently massage with the fingertips to absorb it. The test period is 4 months.

[0127] Table 10: Anti-aging and anti-whitening results

[0128]

[0129] According to Table 10, with the cooperation of 10 volunteers in each group, the clinical test was successfully completed. The control product group without fullerene showed no effective results for 0 people, while the experimental product group containing fullerene showed an effective rate of 70% for 7 people. Figure 5 The actual effect diagram of some users is shown in the figure.

[0130] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the implementation modes. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to specific details.

Claims

1. A composition capable of significantly promoting hair growth, characterized in that: include: Active ingredients, compound additives and water; Wherein, the active components include ammonium acryloyldimethyl taurate / beheneth-25 methacrylate crosspolymer / ammonium acryloyldimethyl taurate / VP copolymer / ammonium acryloyldimethyl taurate / stearyl alcohol polyether methacrylate crosspolymer / hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, fullerene C60 / fullerene C70 / fullerene C60-70 mixture, cyclodextrin / methyl cyclodextrin / hydroxypropyl cyclodextrin / hydroxypropyl γ-cyclodextrin, betaine / matrine / choline / , vitamin E / tocopheryl acetate / tocopheryl linoleate / vitamin E nicotinate, acetyl tetrapeptide-3 / acetyl hexapeptide-1, sodium hyaluronate / hydrolyzed sodium hyaluronate / sodium hyaluronate crosspolymer / acetylated sodium hyaluronate.

2. The composition capable of significantly promoting hair growth according to claim 1, characterized in that: The composite additive comprises riboflavin, biotin, pyridoxine hydrochloride, methyl salicylate, pyrrolidine diaminopyrimidine oxide, diaminopyrimidine oxide, piperine or water-soluble azone.

3. The composition capable of significantly promoting hair growth according to claim 1, characterized in that: The composition comprises, by weight percentage, 6.3-25.2% of active components, 1.4-5.6% of composite additives and the balance of water.

4. The composition capable of significantly promoting hair growth according to claim 3, characterized in that: The composition comprises, by weight percentage, 1-4% ammonium acryloyldimethyltaurate / behenyl ether-25 methacrylate cross-polymer, 0.003-0.5% fullerene, 1-5% hydroxypropyl cyclodextrin, 1-5% betaine, 0.01-1% sodium hyaluronate, 0.25-10% tocopheryl acetate, 0.02-3% biotin, 0.02-2% pyridoxine hydrochloride, 0.25-1% vitamin E nicotinate or water-soluble azone, 0.5-2% acetyl tetrapeptide-3, 0.5-2% pyrrolidino diaminopyrimidine oxide and the remainder water.

5. The composition capable of significantly promoting hair growth according to claim 4, characterized in that: The composition comprises, by weight percentage, 2% ammonium acryloyldimethyltaurate / behenyl ether-25 methacrylate crosspolymer, 0.11% fullerene, 2% hydroxypropyl cyclodextrin, 2% betaine, 0.05% sodium hyaluronate, 0.5% tocopheryl acetate, 0.05% biotin, 0.05% pyridoxine hydrochloride, 0.5% vitamin E nicotinate or water-soluble azone, 1% acetyl tetrapeptide-3, 1% pyrrolidinodiaminopyrimidine oxide and the balance water.

6. The composition capable of significantly promoting hair growth according to claim 1, characterized in that: The active ingredients include ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer, fullerene C60, hydroxypropyl cyclodextrin, betaine, tocopheryl acetate, vitamin E nicotinate, acetyl tetrapeptide-3 and sodium hyaluronate.

7. A method for preparing a composition capable of significantly promoting hair growth as claimed in any one of claims 1 to 6, characterized in that: The following steps are involved: The active component, the composite solubilizer and water are mixed, stirred at 80-90° C. for 10-40 minutes, and then the composite additive and preservative are added to the obtained mixture after cooling to room temperature, and stirred evenly to obtain the composition capable of significantly promoting hair growth.

8. An application of the composition capable of significantly promoting hair growth and turning white hair into black as claimed in any one of claims 1 to 6, which is used in combination with Minoxidil to promote hair growth, and the application method is: first apply the Minoxidil preparation to the part where hair growth is to be performed, and then apply the composition product.

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