Micro-pipetting device and pipetting platform

Abstract

The invention provides a micropipetting device and a pipetting platform, and the micropipetting device comprises a base which is provided with at least one pipetting channel penetrating through the base; the first end of the pipetting rod assembly is located in the pipetting channel and can slide in the pipetting channel, and the pipetting rod assembly is in sealed contact with the inner wall surface of the pipetting channel; and the driving assembly is arranged on the base, is connected with the second end of the pipetting rod assembly and is used for driving the pipetting rod assembly to slide in the pipetting channel. According to the micro-pipetting device provided by the invention, the pipetting amount can be more accurately controlled, other parts do not need to be additionally arranged, the overall structure of the micro-pipetting device can be simplified, the cost can be reduced, and the micro-pipetting device can be more miniaturized.

Description

Technical Field

[0001] The present invention relates to the technical field of liquid transfer equipment, in particular to a micro-liquid transfer device and a liquid transfer platform. Background Art

[0002] When the current micropipette device transfers the sample to the test paper (or other reaction container), the amount of liquid to be transferred needs to be strictly controlled, usually using a manual pipette gun or a micro plunger pump. The manual pipette gun requires the operator to participate in the whole process, and because each person's operating technique is different, there will be a large difference in the amount of liquid to be transferred. Automatic micropipette is usually implemented by multiple micro plunger pumps plus pipette needles. The system cost is high and there are many pipelines, which is not conducive to miniaturization.

[0003] Therefore, how to design a micro-pipette device that can accurately transfer liquids, is low-cost, and can be miniaturized has become a problem that needs to be solved urgently. Summary of the invention

[0004] The present invention aims to at least solve the problems that the pipette cannot transfer liquid accurately, has high cost and cannot be miniaturized.

[0005] To this end, a first aspect of the present invention provides a micro-pipette device.

[0006] A second aspect of the present invention provides a pipetting platform.

[0007] In view of this, the first aspect of the present invention proposes a micro-pipette device, comprising: a base, on which is provided at least one pipetting channel passing through the base; a pipetting rod assembly, wherein the first end of the pipetting rod assembly is located in the pipetting channel and can slide in the pipetting channel, and the pipetting rod assembly is in sealing contact with the inner wall surface of the pipetting channel; a driving assembly, which is arranged on the base and connected to the second end of the pipetting rod assembly, and is used to drive the pipetting rod assembly to slide in the pipetting channel.

[0008] The micro-pipetting device provided by the present invention comprises a base, a pipetting rod assembly and a driving assembly. The base is provided with at least one pipetting channel penetrating the base, the first end of the pipetting rod assembly is arranged in the pipetting channel, and can slide in the pipetting channel, and because the pipetting rod assembly is in sealing contact with the inner wall surface of the pipetting channel, when the pipetting rod assembly slides in the pipetting channel, negative pressure can be generated in the pipetting channel, and then fluids such as gas or liquid can be sucked into the pipetting channel to realize the movement of the fluid. At the same time, in order to facilitate the control of the amount of liquid transferred, a driving assembly can also be arranged on the base to drive the pipetting rod assembly to slide, and compared with the scheme of manually controlling the pipetting rod assembly to slide, the driving assembly can be arranged to control the amount of liquid transferred more accurately. It can be understood that the present application is to arrange the pipetting channel on the base, and the driving assembly is also arranged on the base, and no other parts need to be arranged additionally, so the overall structure of the micro-pipetting device can be simplified, the cost can be reduced, and the micro-pipetting device can be arranged in a more miniaturized manner.

[0009] The micropipette device provided by the present invention may also have the following additional technical features: In some embodiments, optionally, the micropipette device further comprises: a sealing member disposed in the pipetting channel and used for sealing a gap between the pipetting rod assembly and an inner wall surface of the pipetting channel.

[0010] In this embodiment, optionally, in order to ensure the seal between the pipette rod assembly and the inner wall surface of the pipette channel and ensure the effect of pipetting, a seal can be set in the pipette channel, for example, at one end of the pipette channel, and the seal is used to seal the gap between the pipette rod assembly and the inner wall surface of the pipette channel, thereby ensuring the pipetting effect.

[0011] In some embodiments, optionally, the cross-section of the pipetting channel is circular, polygonal, or a combination thereof.

[0012] In this embodiment, the cross section of the pipetting channel can be set to a circular shape or a polygonal shape, or a combination of the two, and the specific shape can be set according to actual conditions. In order to ensure the pipetting effect, preferably, the cross section of the pipetting channel can be set to a circular shape.

[0013] In some embodiments, optionally, the micropipette device further comprises: a fixed seat, which is disposed at the second end of the pipetting rod assembly and connected to the driving assembly, and the driving assembly can drive the pipetting rod assembly to move along the axial direction of the pipetting channel through the fixed seat.

[0014] In this embodiment, optionally, in order to facilitate the driving of the pipetting rod assembly, a fixing seat can be provided at the second end of the pipetting rod assembly, and then the fixing seat can be connected to the driving assembly, so that the fixing seat can be driven to move by the driving assembly, and the pipetting rod assembly can be driven by the fixing seat to move along the axial direction of the pipetting channel to achieve the suction or discharge of the liquid. It can be understood that in the micro-pipette device, the pipetting rod assembly is relatively thin and relatively low in strength. Therefore, the present application drives the pipetting rod assembly to slide by providing a fixing seat, which can ensure the stability of the sliding and improve the service life of the micro-pipette device.

[0015] In some embodiments, optionally, the micropipette device also includes: a mounting groove, which is arranged on a fixed seat; an elastic component, which is arranged in the mounting groove, and the second end of the pipetting rod assembly is arranged in the mounting groove and abuts against the elastic component. The elastic component can undergo elastic deformation along the axial direction of the pipetting channel under the action of the pipetting rod assembly.

[0016] In this embodiment, optionally, in order to facilitate the installation of the pipetting rod assembly in the pipetting channel during assembly, a mounting groove can be provided on the fixed seat, and then an elastic component is provided in the mounting groove, and the second end of the pipetting rod assembly is abutted against the elastic component, so that the elastic component can be elastically deformed along the axial direction of the pipetting channel under the action of the pipetting rod assembly. In this way, when assembling the pipetting rod assembly and the pipetting channel, the pipetting rod assembly can be pressed so that the pipetting rod assembly compresses the spring, thereby facilitating the first end of the pipetting rod assembly to be installed in the pipetting channel. This arrangement can greatly reduce the requirements for structural parts processing accuracy and assembly accuracy.

[0017] In some embodiments, optionally, the elastic component includes: a spring, which is disposed in the mounting groove; a spring support cover, which is disposed in the mounting groove and is located between the spring and the second end of the pipetting rod assembly, and the second end of the pipetting rod assembly abuts against the spring support cover.

[0018] In this embodiment, the elastic component can be optionally set as a spring, which has good elasticity, low cost and is easy to set, so the cost can be further reduced and the structure can be simplified. Specifically, the spring can be set in the installation groove along the axial direction of the pipetting channel, and then the spring support cover is also set in the installation groove and is located between the spring and the second end of the pipetting rod assembly, so that the second end of the pipetting rod assembly abuts against the spring support cover, so that the spring can be squeezed by the spring support cover to avoid uneven force on the spring and deformation.

[0019] In some embodiments, optionally, the micropipette device further comprises: a guide assembly mounted on the base, the fixed seat is slidably mounted on the guide assembly, and the guide assembly is used to guide the fixed seat to slide along the axial direction of the pipetting channel.

[0020] In this embodiment, optionally, a guide assembly can be provided to provide guidance to prevent the pipetting rod assembly from being subjected to radial force, which causes deformation of the pipetting rod assembly. Specifically, the guide assembly can be installed on the base, and then the fixed seat can be slidably installed on the guide assembly, so that the guide assembly can guide the fixed seat to slide along the axial direction of the pipetting channel, so that when the fixed seat drives the pipetting rod assembly to slide, the sliding of the pipetting rod assembly can be guided.

[0021] In some embodiments, optionally, the guide assembly includes: a guide shaft, one end of which is mounted on the base, and the guide shaft is arranged along the axial direction of the pipetting channel, and the fixed seat is slidably mounted on the guide shaft.

[0022] In this embodiment, the guide assembly can be optionally configured as a guide shaft, one end of the guide shaft is mounted on the base, and the guide shaft is arranged along the axial direction of the pipetting channel, and the fixed seat is slidably mounted on the guide shaft, so that the guide shaft can be used for guiding. The guide shaft is provided for guiding, and its setting is relatively simple and the structure is also simple, so it is conducive to the miniaturization of the micro-pipetting device.

[0023] In some embodiments, optionally, the micropipette device further includes a mounting hole disposed on the fixed seat, and the guide assembly further includes: a sleeve disposed in the mounting hole, and the fixed seat is slidably matched with the guide shaft through the sleeve.

[0024] In this embodiment, optionally, in order to facilitate better movement of the fixing seat on the guide shaft, a shaft sleeve may be provided, and the shaft sleeve may be fixedly installed in the mounting hole of the fixing seat, thereby utilizing the shaft sleeve to improve the fit between the fixing seat and the guide shaft.

[0025] In some embodiments, optionally, the micropipette device further comprises: a sleeve pressure cover, which is disposed on the fixing seat and is used to limit the position of the sleeve.

[0026] In this embodiment, optionally, in order to prevent the shaft sleeve from falling and improve the stability of the shaft sleeve, a shaft sleeve pressure cover may be provided to limit the position of the shaft sleeve.

[0027] In some embodiments, optionally, the guide assembly includes: a guide seat installed on the base, the guide seat is provided with a slideway arranged along the axial direction of the pipetting channel, and the fixed seat is slidably installed in the slideway.

[0028] In this embodiment, the guide assembly can be optionally configured as a guide seat, the guide seat is mounted on the base, and a slideway is provided on the guide seat along the axial direction of the pipetting channel, so that when the fixed seat is mounted on the slideway, the slideway can be used to guide the sliding of the fixed seat. Of course, the guide assembly can also be other guide structures, as long as the guide is stable, easy to install and conducive to miniaturization.

[0029] In some embodiments, optionally, the micropipette device further comprises: a sealing gland, disposed on the base, for limiting the sliding movement of the sealing member.

[0030] In this embodiment, optionally, in order to prevent the seal from sliding out of the transfer channel, a sealing gland may be provided on the base to limit the sliding of the seal. Specifically, the sealing gland may be provided at the opening of the transfer channel.

[0031] In some embodiments, optionally, the micropipette device further includes: a pipetting head, detachably mounted on the base and connected to the pipetting channel.

[0032] In this embodiment, optionally, in order to facilitate the aspiration of liquid, a pipetting head may be provided, and the pipetting head may be detachably mounted on the base so that the pipetting head is in communication with the pipetting channel.

[0033] In some embodiments, optionally, the pipetting head includes: a mounting seat, which is detachably mounted on the base; a suction head, which is disposed on the mounting seat and is connected to the pipetting channel, and a liquid containing cavity is disposed in the suction head for containing liquid.

[0034] In this embodiment, optionally, the pipette head includes a mounting seat and a suction tip. The mounting seat is detachably mounted on the base. The suction tip is arranged on the mounting seat and is connected to the pipetting channel, so that the pipette head can be used to absorb liquid and realize pipetting. At the same time, a liquid containing cavity can be provided in the suction tip, and the liquid containing cavity is used to contain liquid, so that when the liquid is sucked, it will be stored in the liquid containing cavity of the suction tip, and will not enter the mounting seat of the suction tip and the pipetting channel. Therefore, the liquid will only contaminate the suction tip, and only the suction tip needs to be replaced each time. It can be understood that the provision of a detachable mounting seat enables the pipette head to be replaced regularly to prevent contamination, which is suitable for short-term reusable scenarios.

[0035] In some embodiments, optionally, there are multiple pipetting channels, and the multiple pipetting channels are arranged at intervals.

[0036] In this embodiment, optionally, a plurality of pipetting channels can be provided so that more liquids can be transferred, and the specific number of pipetting channels can be set according to actual conditions.

[0037] In some embodiments, optionally, there are multiple pipetting rod assemblies, and the multiple pipetting rod assemblies correspond one-to-one to the multiple pipetting channels.

[0038] In this embodiment, optionally, when there are multiple pipetting channels, multiple pipetting rod assemblies can also be provided so that the multiple pipetting rod assemblies correspond one-to-one to the multiple pipetting channels, thereby ensuring the stability of pipetting.

[0039] In some embodiments, optionally, the cross-sectional areas of the plurality of pipetting rod assemblies are the same or different.

[0040] In this embodiment, the cross-sectional areas of the plurality of pipetting rod assemblies may be optionally set to be the same or different, thereby achieving multi-channel pipetting of the same volume or different volumes, thereby meeting usage requirements.

[0041] In some embodiments, optionally, the drive assembly includes at least one of a motor, an air pump, and a hydraulic pump.

[0042] In some embodiments, optionally, the drive assembly includes a drive shaft, which is a screw shaft, and the micropipette device also includes: a screw nut, which is arranged at the second end of the pipetting rod assembly, and the screw shaft can cooperate with the screw nut to drive the pipetting rod assembly to slide in the pipetting channel.

[0043] In this embodiment, optionally, in order to facilitate the driving of the pipetting rod assembly, a screw nut can be provided at the second end of the pipetting rod assembly, and then the screw nut is matched with the screw shaft of the driving assembly, so that when the screw shaft rotates, the screw nut can be driven to move, thereby driving the pipetting rod assembly to slide in the pipetting channel. The moving direction of the pipetting rod assembly can be adjusted by the forward and reverse rotation of the screw shaft.

[0044] The second aspect of the present invention provides a pipetting platform, comprising the micro-pipetting device in any technical solution of the first aspect.

[0045] The pipetting platform provided by the present invention includes the micro-pipette device in any one of the technical solutions of the first aspect. Since the pipetting platform includes the micro-pipette device in any one of the technical solutions of the first aspect. Therefore, the pipetting platform provided by the present invention also has all the beneficial effects of the micro-pipette device in any one of the technical solutions of the first aspect, which will not be repeated here.

[0046] In some embodiments, optionally, the pipetting platform further includes: a displacement device connected to the micropipette device and capable of driving the micropipette device to move in one or more directions.

[0047] In this embodiment, optionally, a displacement device may be provided to be connected to the micropipette device, so that the displacement device can be used to drive the micropipette device to move in one or more directions, thereby meeting different usage requirements.

[0048] Additional aspects and advantages of the present invention will become apparent in the following description or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which: Figure 1 An exploded view of a micropipette device according to an embodiment of the present invention is shown; Figure 2 One of the structural schematic diagrams of a micro-pipette device according to an embodiment of the present invention is shown; Figure 3 One of the partial structural schematic diagrams of a micro-pipette device according to an embodiment of the present invention is shown; Figure 4 Shows Figure 3 The enlarged view of point A in the middle; Figure 5 A second structural schematic diagram of a micro-pipette device according to an embodiment of the present invention is shown; Figure 6 A second partial structural schematic diagram of a micro-pipette device according to an embodiment of the present invention is shown; Figure 7 A schematic structural diagram of a liquid transfer platform according to an embodiment of the present invention is shown.

[0050] in, Figures 1 to 7 The corresponding relationship between the reference numerals and the component names is as follows: 1 pipetting platform, 10 micropipette device, 100 base, 1002 pipetting channel, 101 pipetting rod assembly, 102 drive assembly, 1022 drive shaft, 1024 screw shaft, 103 fixed seat, 104 mounting groove, 105 elastic component, 1052 spring, 1054 spring support cover, 106 guide assembly, 1062 guide shaft, 1064 sleeve, 107 mounting hole, 108 sleeve gland, 109 sealing gland, 110 pipetting head, 1102 mounting seat, 1104 suction tip, 1106 liquid chamber, 111 screw nut, 112 sealing, 20 displacement device. DETAILED DESCRIPTION

[0051] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0052] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0053] Refer to the following Figures 1 to 7 The present invention describes a micropipette device and a pipetting platform according to some embodiments of the present invention.

[0054] According to an embodiment of the first aspect of the present invention, Figures 1 to 6 As shown, the first aspect of the present invention provides a micropipette device 10, comprising a base 100, a pipetting rod assembly 101 and a drive assembly 102. The base 100 is provided with at least one pipetting channel 1002 that penetrates the base 100. The first end of the pipetting rod assembly 101 is located in the pipetting channel 1002 and can slide in the pipetting channel 1002, and the pipetting rod assembly 101 is in sealing contact with the inner wall surface of the pipetting channel 1002. The drive assembly 102 is provided on the base 100 and connected to the second end of the pipetting rod assembly 101, and is used to drive the pipetting rod assembly 101 to slide in the pipetting channel 1002.

[0055] The micro-pipette device 10 provided by the present invention comprises a base 100, a pipetting rod assembly 101 and a driving assembly 102. The base 100 is provided with at least one pipetting channel 1002 penetrating the base 100, and the first end of the pipetting rod assembly 101 is arranged in the pipetting channel 1002, and can slide in the pipetting channel 1002, and because the pipetting rod assembly 101 is in sealing contact with the inner wall surface of the pipetting channel 1002, when the pipetting rod assembly 101 slides in the pipetting channel 1002, negative pressure can be generated in the pipetting channel 1002, and then fluids such as gas or liquid can be sucked into the pipetting channel 1002 to achieve the movement of the fluid. At the same time, in order to facilitate the control of the amount of liquid to be pipetted, the driving assembly 102 can also be arranged on the base 100 to drive the pipetting rod assembly 101 to slide. Compared with the solution of manually controlling the pipetting rod assembly 101 to slide, the setting of the driving assembly 102 can more accurately control the amount of liquid to be pipetted. It can be understood that the present application sets the pipetting channel 1002 on the base 100, and also sets the driving assembly 102 on the base 100, without the need to set up other additional parts. Therefore, the overall structure of the micropipette device 10 can be simplified, the cost can be reduced, and the micropipette device 10 can be set in a more miniaturized manner.

[0056] In some embodiments, optionally, Figure 2 As shown, the micropipette device 10 further includes: a sealing member 112 disposed in the pipetting channel 1002 for sealing the gap between the pipetting rod assembly 101 and the inner wall surface of the pipetting channel 1002 .

[0057] In this embodiment, optionally, in order to ensure the seal between the pipetting rod assembly 101 and the inner wall surface of the pipetting channel 1002 and ensure the effect of aspirating and discharging liquid, a seal 112 can be set in the pipetting channel 1002, for example, at one end of the pipetting channel 1002, and the seal 112 is used to seal the gap between the pipetting rod assembly 101 and the inner wall surface of the pipetting channel 1002, thereby ensuring the pipetting effect.

[0058] In some embodiments, optionally, the seal 112 is a sealing ring.

[0059] In some embodiments, optionally, the sealing ring is an O-ring or a polygonal sealing ring.

[0060] In some embodiments, optionally, the cross-section of the pipetting channel 1002 is circular, polygonal, or a combination thereof.

[0061] In this embodiment, the cross section of the pipetting channel 1002 can be set to a circular shape or a polygonal shape, or a combination of the two, and the specific shape can be set according to actual conditions. In order to ensure the pipetting effect, preferably, the cross section of the pipetting channel 1002 can be set to a circular shape.

[0062] In some embodiments, optionally, Figure 2 As shown, the micropipette device 10 further includes: a fixing seat 103, which is disposed at the second end of the pipetting rod assembly 101 and is connected to the driving assembly 102. The driving assembly 102 can drive the pipetting rod assembly 101 along the axial direction of the pipetting channel 1002 ( Figure 2 Move in the direction indicated by C in the middle.

[0063] In this embodiment, optionally, in order to facilitate the driving of the pipetting rod assembly 101, a fixing seat 103 can be set at the second end of the pipetting rod assembly 101, and then the fixing seat 103 can be connected to the driving assembly 102, and then the fixing seat 103 can be driven to move by the driving assembly 102, and the pipetting rod assembly 101 is driven to move along the axial direction of the pipetting channel 1002 by the fixing seat 103, so as to achieve the suction or discharge of the liquid. It is understandable that in the micro-pipetting device 10, the pipetting rod assembly 101 is relatively thin and the strength is relatively low, so the present application drives the pipetting rod assembly 101 to slide by setting the fixing seat 103. Since the pipetting rod assembly 101 is directly and movably connected with the fixing seat 103, the stability of sliding can be ensured, and the service life of the micro-pipetting device 10 is improved.

[0064] In some embodiments, optionally, the fixing seat 103 can be movably disposed at the second end of the pipetting rod assembly 101 .

[0065] In some embodiments, optionally, Figure 3 and Figure 4As shown, the micropipette device 10 also includes: a mounting groove 104, which is arranged on the fixing seat 103; an elastic component 105, which is arranged in the mounting groove 104, and the second end of the pipetting rod assembly 101 is arranged in the mounting groove 104, abutting against the elastic component 105, and the elastic component 105 can undergo elastic deformation along the axial direction of the pipetting channel 1002 under the action of the pipetting rod assembly 101 and the fixing seat 103.

[0066] In this embodiment, optionally, in order to facilitate the installation of the pipetting rod assembly 101 in the pipetting channel 1002 during assembly, a mounting groove 104 can be set on the fixing seat 103, and then an elastic component 105 can be set in the mounting groove 104, and the second end of the pipetting rod assembly 101 can be abutted against the elastic component 105, so that the elastic component 105 can be elastically deformed along the axial direction of the pipetting channel 1002 under the action of the pipetting rod assembly 101 and the fixing seat 103. In this way, when assembling the pipetting rod assembly 101 and the pipetting channel 1002, the pipetting rod assembly 101 can be pressed so that the pipetting rod assembly 101 compresses the spring 1052, thereby facilitating the first end of the pipetting rod assembly 101 to be installed in the pipetting channel 1002. This arrangement can greatly reduce the requirements for structural parts processing accuracy and assembly accuracy.

[0067] In some embodiments, optionally, the elastic component 105 includes: a spring 1052, which is disposed in the mounting groove 104; a spring support cover 1054, which is disposed in the mounting groove 104 and is located between the spring 1052 and the second end of the pipette rod assembly 101, and the second end of the pipette rod assembly 101 abuts against the spring support cover 1054.

[0068] In this embodiment, the elastic component 105 can be optionally set as a spring 1052, which has good elasticity, low cost and is easy to set, so the cost can be further reduced and the structure can be simplified. Specifically, the spring 1052 can be set in the mounting groove 104 along the axial direction of the liquid transfer channel 1002, and then the spring support cover 1054 is also set in the mounting groove 104 and is located between the spring 1052 and the bottom surface of the mounting groove 104, so that the second end of the liquid transfer rod assembly 101 abuts against the top surface of the mounting groove 104, so that the spring 1052 can be squeezed by the spring support cover 1054 to avoid the spring 1052 from being deformed due to uneven force.

[0069] In some embodiments, optionally, the micropipette device 10 further includes: a guide assembly 106 mounted on the base 100 , the fixed seat 103 is slidably mounted on the guide assembly 106 , and the guide assembly 106 is used to guide the fixed seat 103 to slide along the axial direction of the pipetting channel 1002 .

[0070] In this embodiment, optionally, a guide assembly 106 may be provided for guidance to prevent the pipetting rod assembly 101 from being subjected to radial force, which may cause deformation of the pipetting rod assembly 101. Specifically, the guide assembly 106 may be installed on the base 100, and then the fixed seat 103 may be slidably installed on the guide assembly 106, so that the guide assembly 106 can guide the fixed seat 103 to slide along the axial direction of the pipetting channel 1002, so that when the fixed seat 103 drives the pipetting rod assembly 101 to slide, the sliding of the pipetting rod assembly 101 can be guided.

[0071] In some embodiments, optionally, the guide assembly 106 includes: a guide shaft 1062 , one end of which is mounted on the base 100 , and the guide shaft 1062 is arranged along the axial direction of the pipetting channel 1002 , and the fixed seat 103 is slidably mounted on the guide shaft 1062 .

[0072] In this embodiment, optionally, the guide assembly 106 can be configured as a guide shaft 1062, one end of the guide shaft 1062 is mounted on the base 100, and the guide shaft 1062 is arranged along the axial direction of the pipetting channel 1002, and the fixed seat 103 is slidably mounted on the guide shaft 1062, so that the guide can be guided by the guide shaft 1062. By providing the guide shaft 1062 for guidance, its setting is relatively simple and the structure is also simple, so it is conducive to the miniaturization of the micropipette device 10.

[0073] In some embodiments, optionally, the pipetting rod assembly 101 and the guide shaft 1062 have a preset height difference.

[0074] It can be understood that the radial movement limit of the pipette rod assembly 101 can be achieved by the seal 112 and the fixed seat 103, and its maximum axial displacement can be limited by the height of the guide shaft 1062. By setting the height difference between the pipette rod assembly 101 and the guide shaft 1062, it can be ensured that the pipette rod assembly 1062 will not slip out of the pipette channel 1002 when sliding.

[0075] In some embodiments, optionally, the micropipette device 10 further includes a mounting hole 107 disposed in the fixing seat 103, and the guide assembly 106 further includes: a shaft sleeve 1064 disposed in the mounting hole 107, and the fixing seat 103 cooperates with the guide shaft 1062 through the shaft sleeve 1064. Thus, the fixing seat 103 can slide along the axial direction of the guide shaft 1062.

[0076] In this embodiment, optionally, in order to facilitate better movement of the fixed seat 103 on the guide shaft 1062, a sleeve 1064 may be provided, and the sleeve 1064 may be fixedly installed in the mounting hole 107 of the fixed seat 103, thereby utilizing the sleeve 1064 to improve the fit between the fixed seat 103 and the guide shaft 1062.

[0077] In some embodiments, optionally, the micropipette device 10 further includes: a sleeve pressure cover 108 , which is disposed on the fixing seat 103 and is used to limit the position of the sleeve 1064 .

[0078] In this embodiment, optionally, in order to prevent the shaft sleeve 1064 from falling and improve the stability of the shaft sleeve 1064, a shaft sleeve pressure cover 108 may be provided to limit the shaft sleeve 1064.

[0079] In some embodiments, optionally, the guide assembly 106 includes: a guide seat installed on the base, the guide seat is provided with a slideway arranged along the axial direction of the pipetting channel 1002, and the fixed seat 103 is slidably installed in the slideway.

[0080] In this embodiment, optionally, the guide assembly 106 can also be set as a guide seat, the guide seat is installed on the base, and a slideway is set on the guide seat along the axial direction of the pipetting channel 1002, so that when the fixed seat 103 is installed on the slideway, the slideway can be used to guide the sliding of the fixed seat 103. Of course, the guide assembly 106 can also be other guide structures, as long as the guidance is stable, easy to install and conducive to miniaturization.

[0081] In some embodiments, optionally, the micropipette device 10 further includes: a sealing gland 109 , which is disposed on the base 100 and is used to limit the sliding movement of the sealing member 112 .

[0082] In this embodiment, optionally, in order to prevent the seal 112 from sliding out of the pipetting channel 1002, a sealing gland 109 may be provided on the base 100, and the sealing gland 109 may be used to limit the sliding of the seal 112. Specifically, the sealing gland 109 may be provided at the opening of the pipetting channel 1002. It is understandable that the purpose of providing the sealing gland 109 is to prevent the seal 112 from moving up and down when the pipetting rod assembly 101 moves up and down. Therefore, in order to prevent the seal 112 from shifting, the sealing gland 109 may be provided to limit the displacement of its up and down movement.

[0083] In some embodiments, optionally, the micropipette device 10 further includes: a pipetting head 110 detachably mounted on the base 100 and connected to the pipetting channel 1002 .

[0084] In this embodiment, optionally, in order to facilitate the aspiration of liquid, a pipetting head 110 may be provided, and the pipetting head 110 may be detachably mounted on the base 100 so that the pipetting head 110 is in communication with the pipetting channel 1002 .

[0085] In some embodiments, optionally, the pipetting head 110 includes: a mounting seat 1102 detachably mounted on the base 100 ; a suction head 1104 disposed on the mounting seat 1102 and connected to the pipetting channel 1002 , and a liquid containing cavity 1106 is disposed in the suction head 1104 for containing liquid.

[0086] In this embodiment, optionally, the pipetting head 110 includes a mounting seat 1102 and a suction head 1104. The mounting seat 1102 is detachably mounted on the base 100. The suction head 1104 is arranged on the mounting seat 1102 and is connected to the pipetting channel 1002, so that the pipetting head 110 can be used to absorb liquid and achieve pipetting. At the same time, a liquid containing cavity 1106 can be arranged in the suction head 1104, and the liquid containing cavity 1106 is used to contain liquid, so that when the liquid is sucked, it will be stored in the liquid containing cavity 1106 of the suction head 1104, and will not enter the mounting seat 1102 of the suction head 1104 and the pipetting channel 1002, so the liquid will only contaminate the suction head 1104, and the suction head 1104 only needs to be replaced each time. It can be understood that the provision of a detachable mounting seat 1102 allows the pipetting head 110 to be replaced regularly to prevent contamination, which is suitable for short-term reusable scenarios.

[0087] In some embodiments, the pipetting head 110 can be configured as a pipetting needle according to the amount of liquid to be pipetted. A thinner pipetting needle is convenient for micro-pipetting.

[0088] In some embodiments, optionally, the micropipette device 10 also includes a tip 1104 installation device and a tip 1104 unloading and recovery device, so that the tip 1104 installation device can be used to automatically install the tip 1104, and the tip 1104 unloading and recovery device can be used to automatically unload and recover the tip 1104, thereby realizing a fully automatic closed loop and improving the degree of automation of the micropipette device 10.

[0089] In some embodiments, optionally, Figure 5 As shown, there are multiple pipetting channels 1002, and the multiple pipetting channels 1002 are arranged at intervals.

[0090] In this embodiment, optionally, a plurality of pipetting channels 1002 can be provided so that more liquids can be transferred. The specific number of pipetting channels 1002 can be provided according to actual conditions.

[0091] In some embodiments, optionally, the number of the pipetting channels 1002 is set to four.

[0092] In some embodiments, optionally, there are multiple pipetting rod assemblies 101 , and the multiple pipetting rod assemblies 101 correspond one-to-one to the multiple pipetting channels 1002 .

[0093] In this embodiment, optionally, when there are multiple pipetting channels 1002, multiple pipetting rod assemblies 101 can also be provided, so that the multiple pipetting rod assemblies 101 correspond one-to-one to the multiple pipetting channels 1002, thereby ensuring the stability of pipetting.

[0094] In some embodiments, optionally, the cross-sectional areas of the plurality of pipetting rod assemblies 101 are the same or different.

[0095] In this embodiment, the cross-sectional areas of the plurality of pipetting rod assemblies 101 may be optionally set to be the same or different, thereby achieving multi-channel pipetting of the same volume or different volumes, thereby meeting usage requirements.

[0096] The theoretical value of the liquid transfer volume is the diameter of the liquid transfer rod assembly 101×the moving distance.

[0097] In some embodiments, optionally, the drive assembly 102 includes at least one of a motor, an air pump, and a hydraulic pump.

[0098] In some embodiments, optionally, the motor is a stepper motor.

[0099] In some embodiments, optionally, the driving assembly 102 includes a driving shaft 1022, which is a screw shaft 1024, and the micropipette device 10 also includes: a screw nut 111, which is arranged at the second end of the pipetting rod assembly 101, and the screw shaft 1024 can cooperate with the screw nut 111 to drive the pipetting rod assembly 101 to slide in the pipetting channel 1002.

[0100] In this embodiment, optionally, in order to facilitate the driving of the pipetting rod assembly 101, a screw nut 111 can be provided at the second end of the pipetting rod assembly 101, and then the screw nut 111 is matched with the screw shaft 1024 of the driving assembly 102, so that when the screw shaft 1024 rotates, the screw nut 111 can be driven to move, thereby driving the pipetting rod assembly 101 to slide in the pipetting channel 1002. The moving direction of the pipetting rod assembly 101 can be adjusted by the forward and reverse rotation of the screw shaft 1024.

[0101] In a specific embodiment, optionally, the screw nut 111 can be set on the fixed seat 103, and then the screw shaft 1024 can be screwed together with the screw nut 111, so that the fixed seat 103 can be rotated along the screw shaft 1024 to achieve axial movement of the screw shaft 1024, thereby driving the pipetting rod assembly 101 to slide in the pipetting channel 1002 through the fixed seat 103.

[0102] According to an embodiment of the first aspect of the present invention, a micropipette device 10 is proposed, which includes a piston pull rod (fixed seat 103), a guide shaft 1062, a piston rod (pipette rod assembly 101), a compression spring 1052, a sleeve 1064, a spring support cover 1054, a sleeve gland 108, a sealing gland 109, a screw stepper motor (drive assembly 102), an O-ring (seal 112), a sealing cavity (base 100), a pipette needle and a screw nut 111.

[0103] In some embodiments, optionally, the pipette needle is fixed to the sealed cavity by a threaded connection.

[0104] In some embodiments, the guide shaft 1062 is optionally fixed to the sealing cavity by threaded connection, the inner hole of the sleeve 1064 and the guide shaft 1062 form an axial hole, the outer axial surface of the sleeve 1064 matches the corresponding hole position of the piston rod, and the sleeve gland 108 is locked on the piston rod by screws, which limits the axial movement of the sleeve 1064. Therefore, when the piston rod moves along the axial direction of the guide shaft 1062, the guide shaft 1062 plays a guiding role, so that the piston rod is not subjected to radial force, thereby causing the piston rod to deform. Because for the micropipette device 10, the diameter of the piston rod is usually very small, and the radial force it can withstand is relatively small.

[0105] In some embodiments, optionally, the compression spring 1052 and the spring support cover 1054 cooperate with the piston rod axially in sequence and are finally installed in the hole corresponding to the piston pull rod. Relying on the elastic force of the compression spring 1052, the piston rod is movably fixed (it can be displaced and is not fixed like a screw. Its purpose is to allow the four piston rods to be inserted into the corresponding holes of the sealing cavity during assembly. This movable fixing method can greatly reduce the processing accuracy and assembly accuracy requirements of the structural parts).

[0106] In some embodiments, optionally, the screw stepper motor and the sealing cavity are both fixedly connected to the sealing gland 109 by screws, and the sealing gland 109 also limits the axial movement of the O-ring.

[0107] In some embodiments, optionally, the lead screw nut 111 is movably connected to the output shaft lead screw of the lead screw stepper motor through its thread, and can move axially along the output shaft lead screw shaft 1024, while the lead screw nut 111 is fixedly connected to the piston pull rod through a screw.

[0108] Through the above structural design and fixed connection, when the screw stepper motor rotates, it drives the screw nut 111 to move up and down (the moving direction of the screw nut 111 can be changed by switching the rotation direction of the screw stepper motor). Since the screw nut 111 is fixedly connected to the piston pull rod, the piston pull rod is also driven to move up and down. At this time, because the piston rod is movably fixed in the corresponding hole position of the piston pull rod, and the piston rod and the piston pull rod are fixed in the vertical direction of movement, the piston rods of the four channels are also driven to move up and down. The piston rod and the O-ring cooperate to form four independent sealed chambers with the four channels corresponding to the sealing cavity. When the piston rod moves upward, air, liquid and other fluids can be sucked in from the end of the pipette needle. When the piston rod moves downward, the air or liquid in the four independent sealed chambers can be discharged from the end of the pipette needle.

[0109] In some embodiments, optionally, the lead screw stepper motor is arranged on one side of the sealed cavity, and it can be arranged on the other side or the upper part according to actual needs.

[0110] In some embodiments, optionally, the sealed cavity is provided with 4 independent channels to achieve pipetting of the 4 channels simultaneously, and the number of channels can be increased or decreased according to actual conditions.

[0111] In some embodiments, optionally, the diameters of the piston rods of the four channels are the same to achieve pipetting of the same volume in the four channels. The piston rod diameters can be set to different values ​​according to actual conditions to achieve pipetting of different volumes in each channel.

[0112] In some embodiments, the pipette needle can be replaced periodically to prevent contamination. This is suitable for short-term reusable use. For one-time use, please refer to Figure 6 shown.

[0113] like Figure 6 As shown, after the liquid is sucked in, it is stored in the cavity of the suction head 1104, and does not enter the suction head 1104 mounting seat 1102 and the corresponding channel of the sealed cavity. Therefore, the liquid will only contaminate the suction head 1104, and only the suction head 1104 needs to be replaced each time. By integrating the automatic suction head 1104 installation device and the suction head 1104 unloading and recycling device, the whole process can form a fully automatic closed loop.

[0114] like Figure 7 As shown, the second aspect of the present invention proposes a pipetting platform 1, comprising the micro-pipette device 10 in any embodiment of the first aspect.

[0115] The pipetting platform 1 provided by the present invention includes the micro-pipette device 10 in any one of the embodiments of the first aspect. Since the pipetting platform 1 includes the micro-pipette device 10 in any one of the embodiments of the first aspect. Therefore, the pipetting platform 1 provided by the present invention also has all the beneficial effects of the micro-pipette device 10 in any one of the embodiments of the first aspect, which will not be repeated here.

[0116] In some embodiments, optionally, the pipetting platform 1 further includes: a displacement device 20 connected to the micro-pipette device 10 and capable of driving the micro-pipette device 10 to move in one or more directions.

[0117] In this embodiment, optionally, a displacement device 20 may be provided to be connected to the micropipette device 10 , so that the displacement device 20 can be used to drive the micropipette device 10 to move in one or more directions, thereby meeting different usage requirements.

[0118] In some embodiments, optionally, the displacement device 20 can drive the micropipette device 10 to move in the horizontal direction and the vertical direction.

[0119] In the present invention, the term "plurality" refers to two or more than two, unless otherwise clearly defined. The terms "installed", "connected", "connected", "fixed", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; "connected" can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0120] In the description of this specification, the description of the terms "one embodiment", "some embodiments", "specific embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0121] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A micropipette device, characterized in that: include: A base, wherein the base is provided with at least one liquid transfer channel penetrating the base; A pipetting rod assembly, wherein the first end of the pipetting rod assembly is located in the pipetting channel and is slidable in the pipetting channel, and the pipetting rod assembly is in sealing contact with the inner wall surface of the pipetting channel; The driving assembly is arranged on the base and connected to the second end of the pipetting rod assembly, and is used for driving the pipetting rod assembly to slide in the pipetting channel.

2. The micropipette device according to claim 1, characterized in that: Also includes: A sealing member is arranged in the pipetting channel and is used for sealing the gap between the pipetting rod assembly and the inner wall surface of the pipetting channel.

3. The micropipette device according to claim 2, characterized in that: The cross section of the pipetting channel is circular, polygonal or a combination thereof.

4. The micropipette device according to claim 1, characterized in that: Also includes: A fixed seat is arranged at the second end of the pipetting rod assembly and is connected to the driving assembly. The driving assembly can drive the pipetting rod assembly to move along the axial direction of the pipetting channel through the fixed seat.

5. The micropipette device according to claim 4, characterized in that: Also includes: A mounting groove, arranged on the fixing seat; The elastic component is arranged in the installation groove. The second end of the pipetting rod component is arranged in the installation groove and abuts against the elastic component. The elastic component can be elastically deformed along the axial direction of the pipetting channel under the action of the pipetting rod component.

6. The micropipette device according to claim 5, characterized in that: The elastic component comprises: A spring, arranged in the mounting groove; The spring support cover is arranged in the installation groove and is located between the spring and the second end of the pipetting rod assembly. The second end of the pipetting rod assembly abuts against the spring support cover.

7. The micropipette device according to claim 4, characterized in that: Also includes: A guide assembly is mounted on the base, and the fixed seat is slidably mounted on the guide assembly. The guide assembly is used to guide the fixed seat to slide along the axial direction of the pipetting channel.

8. The micropipette device according to claim 7, characterized in that: The guide assembly comprises: A guide shaft, one end of which is mounted on the base, and the guide shaft is arranged along the axial direction of the pipetting channel, and the fixing seat is slidably mounted on the guide shaft.

9. The micropipette device according to claim 8, characterized in that: It also includes a mounting hole, which is arranged on the fixing seat, and the guide assembly also includes: A shaft sleeve is arranged in the mounting hole, and the fixing seat is slidably matched with the guide shaft through the shaft sleeve.

10. The micropipette device according to claim 9, characterized in that: Also includes: The shaft sleeve pressure cover is arranged on the fixing seat and is used for limiting the position of the shaft sleeve.

11. The micropipette device according to claim 7, characterized in that: The guide assembly comprises: The guide seat is installed on the base, and a slideway is arranged along the axial direction of the pipetting channel on the guide seat, and the fixed seat is slidably installed in the slideway.

12. The micropipette device according to claim 2 or 3, characterized in that: Also includes: The sealing gland is arranged on the base and is used to limit the sliding movement of the sealing member.

13. The micropipette device according to any one of claims 1 to 11, characterized in that: Also includes: The pipetting head is detachably mounted on the base and communicated with the pipetting channel.

14. The micropipette device according to claim 13, characterized in that: The pipetting head comprises: A mounting base, detachably mounted on the base; The suction head is arranged on the mounting seat and is communicated with the liquid transfer channel. A liquid containing cavity is arranged in the suction head for containing liquid.

15. The micropipette device according to any one of claims 1 to 11, characterized in that: There are multiple pipetting channels, and the multiple pipetting channels are arranged at intervals.

16. The micropipette device according to claim 15, characterized in that: There are multiple pipetting rod assemblies, and the multiple pipetting rod assemblies correspond one-to-one to the multiple pipetting channels.

17. The micropipette device according to claim 15, characterized in that: The cross-sectional areas of the plurality of pipetting rod assemblies are the same or different.

18. The micropipette device according to any one of claims 1 to 11, characterized in that: The drive assembly comprises: At least one of a motor, an air pump, and a hydraulic pump.

19. The micropipette device according to any one of claims 1 to 11, characterized in that: The driving assembly includes a driving shaft, and the driving shaft is a screw shaft. The micropipette device also includes: A screw nut is arranged at the second end of the pipetting rod assembly. The screw shaft can cooperate with the screw nut to drive the pipetting rod assembly to slide in the pipetting channel.

20. A liquid transfer platform, characterized in that: include: A micropipette device as claimed in any one of claims 1 to 19.

21. The liquid transfer platform according to claim 20, characterized in that: Also includes: The displacement device is connected to the micro-pipette device and can drive the micro-pipette device to move in one or more directions.

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