A pharmaceutical production drying device and a flexible production line

Abstract

The present invention belongs to the technical field of pharmaceutical preparation, and specifically is a pharmaceutical production drying device and a flexible production line, comprising: a drying tower, the drying tower comprising an upper cylinder, a middle cylinder, a lower cylinder and a base, an air inlet is provided on one side of the base, an inner cylinder is provided inside the base, an air ring is formed between the outer wall of the inner cylinder and the inner wall of the base, the lower cylinder is sequentially sleeved with jacket 2 and jacket 3 from the inside to the outside, the bottom of jacket 3 is open, the bottom of jacket 2 is provided with an air outlet, a stirring device is installed at the bottom of the lower cylinder, a driving motor is installed inside the inner cylinder, and the output shaft of the driving motor is spline-connected with the input end of the stirring device. Hot air enters the interior of the base through the air inlet, and is blown out from the air outlet after being guided by the air ring, jacket 3 and jacket 2. The design of the air guide plate and the tangential air outlet enables the hot air to form a rotating and rising airflow in the lower cylinder, so that the hot air can evenly and fully contact with the pharmaceutical raw materials, thereby enhancing the drying effect on the pharmaceutical raw materials.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine preparation, in particular to a medicine production drying device and a flexible production line. Background Art

[0002] Drug liquid granulation is the process of processing drug liquid through a series of processes to make particles with a certain shape and size.

[0003] The first step of drug liquid granulation is to dry the drug liquid. Among the currently used drug liquid drying methods, vacuum drying, freeze drying and hot air circulation ovens have unsatisfactory drying effects. Not only are the drying uneven, easy to agglomerate, low in efficiency and long drying time, but the loading and unloading of materials requires manual operation, is easily contaminated, and has a harsh operating environment. Summary of the invention

[0004] The object of the present invention is to provide a medicine production drying device and a flexible production line, wherein the entire production process is carried out in a closed manner, the efficiency is high and the agglomeration is not easy.

[0005] On the one hand, in order to solve the above-mentioned technical problems, the present invention provides a drug production drying device, including a drying tower, the drying tower includes an upper cylinder, a middle cylinder, a lower cylinder and a base which are connected in sequence from top to bottom, a feed port is arranged on one side of the middle cylinder; an air inlet connected to its inner cavity is arranged on one side of the base, an inner cylinder is arranged inside the base, and an air ring is formed between the outer wall of the inner cylinder and the inner wall of the base; the lower cylinder is sequentially sleeved with a jacket two and a jacket three from the inside to the outside, the bottom of the jacket three is open, and the opening contour is adapted to the air ring, and the top of the jacket three is connected to the top of the jacket two The bottom of the jacket 2 is provided with a plurality of groups of air outlets connected to its inner cavity, and the direction of the air outlets is tangent to the side wall of the jacket 2; the inner cavities of the jackets 2 and 3 are both provided with a plurality of groups of support plates, and the lower end of the inner part of the jacket 2 is provided with a plurality of groups of surrounding air guide plates, and the position of the air guide plates is higher than the position of the air outlet; a stirring device is installed at the bottom of the lower cylinder, and the input end of the stirring device passes through the bottom wall of the lower cylinder through a mechanical seal, and a driving motor with an output shaft facing upward is installed inside the inner cylinder, and the output shaft of the driving motor passes through the top wall of the inner cylinder and is spline-connected to the input end of the stirring device.

[0006] Preferably, a jacket is provided on the outer side of the inner cylinder, the inner side of which is evacuated to form a closed environment.

[0007] Preferably, a jacket 1 is provided on the outer side of the inner cylinder, a refrigerant outlet passing through the side wall of the base is provided on the top side of the jacket 1, and a refrigerant inlet passing through the side wall of the base is provided on the bottom side of the jacket 1.

[0008] Preferably, the upper cylinder and the middle cylinder are separated by a bottom plate with holes, and the inner cavity of the upper cylinder is divided into two separation chambers by a partition plate vertically connected to the bottom plate, and a separation component with connecting holes is installed in each separation chamber, and one side of the upper cylinder is provided with exhaust ports respectively connected to the separation chambers, and one end of the exhaust port is provided with an electric control valve.

[0009] Preferably, the separation assembly includes a top plate, a cylinder and a plurality of collecting bags, the lower ends of the collecting bags are fixed to the bottom plate, and the lower end openings of the collecting bags correspond one-to-one to the holes, the top ends of all the collecting bags are fixed to the top plate, one end of the cylinder is hinged to the bottom plate, and the other end of the cylinder is hinged to the top plate, and a guide rod passing through the top plate is provided on the inner top of the upper cylinder.

[0010] Preferably, a material pipe extending into the inner cavity of the middle cylinder is provided on one side of the middle cylinder, and a sprayer facing the lower cylinder is provided at the end of the material pipe.

[0011] Preferably, the upper cylinder, middle cylinder, lower cylinder and base are detachably connected via clamps, a rotating shaft is fixedly mounted on one side of the upper cylinder via a mounting seat, a supporting seat is provided on one side of the middle cylinder, and the lower end of the rotating shaft is rotatably connected to the supporting seat.

[0012] On the other hand, the present invention also provides a flexible production line, comprising a filling device and a pharmaceutical production drying device as described in any one of claims 1 to 4, wherein the filling device comprises a frame, a conveyor belt is mounted on the frame, a support column is arranged on one side of the frame, a base for docking a lower cylinder is arranged on the top of the support column, a material discharge assembly facing the conveyor belt is connected to the lower end of the base, after the drying tower has finished drying the material, the clamp is removed and the middle cylinder is turned over, the lower cylinder is taken out by a robot and mounted to the base by an inverted cover, and a slide valve is arranged on the cover.

[0013] Preferably, the unloading end of the base forms two unloading ports through a dividing plate, and two feeding ports are arranged on the top of the unloading component, one of the unloading ports is connected to one of the feeding ports through screw conveyor 1, and the other unloading port is connected to the other feeding port through screw conveyor 2.

[0014] After adopting the above technical solution, the beneficial effects of the present invention are:

[0015] The entire drying process is carried out in a closed environment of the drying tower, avoiding contamination of the pharmaceutical raw materials by external factors. The hot air enters the base through the air inlet, and is blown out from the air outlet after being guided by the wind ring, jacket three and jacket two. The design of the air guide plate and the tangential air outlet allows the hot air to form a rotating upward airflow in the lower cylinder, so that the pharmaceutical raw materials are in a "boiling" state, so that the hot air can evenly and fully contact the pharmaceutical raw materials, enhancing the drying effect of the pharmaceutical raw materials. The stirring device stirs the pharmaceutical raw materials under the drive of the driving motor to prevent them from agglomerating and promote full contact between the hot air and the pharmaceutical raw materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 It is the structural schematic diagram of the drying tower;

[0018] Figure 2 Schematic diagram of the internal structure of the upper cylinder;

[0019] Figure 3 It is a schematic diagram of the structure of the separation component;

[0020] Figure 4 It is a structural schematic diagram of the lower cylinder;

[0021] Figure 5 This is a schematic diagram of the installation of the middle cylinder;

[0022] Figure 6 It is a schematic diagram of the combination of filling equipment;

[0023] Figure 7 It is a three-dimensional diagram of the filling equipment;

[0024] Figure 8 A top view of the filling equipment.

[0025] Figure markings: 1-base, 2-lower cylinder, 3-middle cylinder, 4-upper cylinder, 5-separation component, 6-electric control valve, 7-exhaust port, 8-material pipe, 9-sprayer, 10-bottom plate, 11-collection bag, 12-top plate, 13-guide rod, 14-partition, 15-cylinder, 16-air inlet, 17-drive motor, 18-inner cylinder, 19-jacket one, 20-stirring device, 21-air guide plate, 22-support plate, 23-air outlet, 24-jacket two, 25-jacket three, 26-rotating shaft, 27-hoop, 28-base, 29-screw conveyor one, 30-unloading component, 31-conveyor belt, 32-frame, 33-support column, 34-screw conveyor two, 35-cover, 36-material dividing plate. DETAILED DESCRIPTION

[0026] The features and exemplary embodiments of various aspects of the present invention will be described in detail below. In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only configured to explain the present invention and are not configured to limit the present invention. For those skilled in the art, the present invention can be implemented without the need for some of these specific details. The following description of the embodiments is only to provide a better understanding of the present invention by illustrating examples of the present invention.

[0027] The directional words appearing in the following description are all directions shown in the figures, and do not limit the specific structure of the present invention. In the description of the present invention, it should also be noted that, unless otherwise clearly specified and limited, the terms "installation" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected or indirectly connected. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0028] A drug production drying device includes a modular drying tower. The drying tower is composed of an upper cylinder 4, a middle cylinder 3, a lower cylinder 2 and a base 1 which are connected in sequence from top to bottom, and adjacent parts are detachably connected by a clamp 27. A rotating shaft 26 is fixedly mounted on one side of the upper cylinder 4 through a mounting seat, and a support seat is provided on one side of the middle cylinder 3, and the lower end of the rotating shaft 26 is rotatably connected to the support seat. After opening the clamp 27 between the upper cylinder 4 and the middle cylinder 3, the middle cylinder 3 is pushed to rotate relative to the upper cylinder 4 for easy cleaning and inspection. A feed port is provided on the side wall of the middle cylinder 3, and a material pipe 8 extending into its inner cavity is provided on one side of the middle cylinder 3, and a sprayer 9 facing the lower cylinder 2 is provided at the end of the material pipe 8.

[0029] An air inlet 16 is provided on one side of the base 1, and the air inlet 16 is connected to the inner cavity of the base 1. An inner cylinder 18 is provided inside the base 1, and a wind ring is formed between the outer wall of the inner cylinder 18 and the inner wall of the base 1. The lower cylinder 2 is sequentially sleeved with a jacket 2 24 and a jacket 3 25 from the inside to the outside, and the bottom of the jacket 3 25 is open, and the opening profile is adapted to the wind ring. The top of the jacket 3 25 is connected to the top of the jacket 2 24, forming a continuous space. The bottom of the jacket 2 24 is provided with a plurality of groups of air outlets 23 connected to its inner cavity, and the air outlets 23 are covered with a layer of breathable and waterproof film, and the direction of the air outlets 23 is tangent to the side wall of the jacket 2 24. The inner cavities of the jacket 2 24 and the jacket 3 25 are both provided with a plurality of groups of support plates 22, and the lower end of the inner part of the jacket 2 24 is provided with a plurality of groups of surrounding and obliquely distributed wind guide plates 21, and the position of the wind guide plates 21 is higher than the position of the air outlet 23. A stirring device 20 is installed at the bottom of the lower cylinder 2, and the input end of the stirring device 20 passes through the bottom wall of the lower cylinder 2 through a mechanical seal. A driving motor 17 with an output shaft facing upward is installed inside the inner cylinder 18. The output shaft of the driving motor 17 passes through the top wall of the inner cylinder 18 and is spline-connected to the input end of the stirring device 20.

[0030] Liquid pharmaceutical raw materials are fed into the lower cylinder 2 from the feed port, and one end of the material pipe 8 is connected to the medicine storage tank, and the medicine storage tank stores a binder. The hot air generated by the air heating device is introduced into the air ring through the air inlet 16, and then blown out from the air outlet 23 through the guidance of the jacket three 25 and the jacket two 24. The design of the air guide plate 21 and the tangential air outlet 23 makes the hot air form a rotating and rising hot air flow in the lower cylinder 2. The continuously rising hot air flow agitates and boils the pharmaceutical raw materials in the lower cylinder 2 into a fluidized state, and replaces and heats with the heat carried by the air flow, and the moisture in the pharmaceutical raw materials is gradually evaporated to form powder. In the fluidized state, the hot air can evenly and fully contact the pharmaceutical raw materials, thereby enhancing the drying effect on the pharmaceutical raw materials. When the humidity sensor in the middle cylinder 3 detects that the internal humidity reaches the set value, the binder in the medicine storage tank is atomized into fine droplets by the sprayer 9 under the action of compressed air, mixed with the preliminarily dried powder, and then bonded into particles, and further dried by the hot air.

[0031] A jacket 19 is provided on the outside of the inner cylinder 18, and the inside of the jacket 19 is evacuated to form a closed environment with low thermal conductivity. The vacuum state greatly reduces the occurrence of heat conduction and convection, and thus can effectively isolate the thermal influence of the high-temperature airflow in the inner cylinder 18 on the drive motor 17. Alternatively, a refrigerant outlet passing through the side wall of the base 1 is provided on the top side of the jacket 19, and a refrigerant inlet passing through the side wall of the base 1 is provided on the bottom side of the jacket 19. By circulating the refrigerant (cooling water, refrigerant, etc.) in the jacket 19, the heat is absorbed and taken away, thereby keeping the temperature of the inner cylinder 18 at a low level. Both of the above methods can ensure that the drive motor 17 operates at a suitable temperature and extend its service life.

[0032] The upper cylinder 4 and the middle cylinder 3 are separated by a bottom plate 10 with holes, and the inner cavity of the upper cylinder 4 is divided into two separation chambers by a partition 14 that is vertical and connected to the bottom plate 10. A separation assembly 5 connected to the holes is installed in each separation chamber, and one side of the upper cylinder 4 is provided with an exhaust port 7 that is connected to the separation chambers respectively, and one end of the exhaust port 7 is provided with an electric control valve 6. The separation assembly 5 includes a top plate 12, a cylinder 15 and a plurality of collection bags 11, the lower end of the collection bag 11 is fixed to the bottom plate 10, and the lower end opening of the collection bag 11 corresponds to the hole one by one, and the top of all the collection bags 11 is fixed to the top plate 12. One end of the cylinder 15 is hinged to the bottom plate 10, and the other end of the cylinder 15 is hinged to the top plate 12. The inner top of the upper cylinder 4 is provided with a guide rod 13 that passes through the top plate 12.

[0033] The two electric control valves 6 are connected to the induced draft device through a three-way pipe. The hot air inside the drying tower is drawn out by the suction force generated by the induced draft device. When the hot air passes through the separation component, some of the particles carried by it are blocked by the collection bag 11 and fall back into the lower cylinder 2. After the induced draft device has been working for a period of time, one of the electric control valves 6 is closed, and the cylinder 15 in the corresponding separation chamber starts to work, driving the top plate 12 to move up and down, causing the collection bag 11 to shake continuously, thereby shaking off the particles attached to the inner wall of the collection bag 11, and the shaken particles fall into the lower cylinder 2. The two electric control valves 6 are controlled alternately to ensure the continuous operation of the system and the effective collection of particles.

[0034] A flexible production line includes a filling device and the above-mentioned pharmaceutical production drying device. The filling device includes a frame 32, on which a conveyor belt 31 for conveying containers is mounted. A support column 33 is provided on one side of the frame 32, and a base 28 for docking the lower cylinder 2 is provided on the top of the support column 33, and a discharge assembly 30 facing the conveyor belt 31 is connected to the lower end of the base 28. The discharge end of the base 28 forms two discharge ports through a dividing plate 36, and the top of the discharge assembly 30 is provided with two feed ports. One of the discharge ports is connected to one of the feed ports through a screw conveyor 29, and the other discharge port is connected to the other feed port through a screw conveyor 2 34. The diameter and pitch of the screw conveyor 2 34 are smaller than the diameter and pitch of the screw conveyor 29 to achieve different discharge amounts.

[0035] In the production of large-capacity container filling, screw conveyor 29 can be used to quickly fill the container and improve production efficiency. In the production of small-capacity container filling, screw conveyor 234 can be used to accurately adjust the discharge amount. The design difference in diameter and pitch of screw conveyor 234 and screw conveyor 29 is to achieve different discharge amounts, thereby meeting the flexibility and adaptability of the flexible production line under different production requirements.

[0036] When the medicine raw materials in the lower cylinder 2 are dried into particles, the clamps 27 at both ends are removed, the middle cylinder 3 is pushed to rotate relative to the upper cylinder 4, and the external manipulator snaps the cover 35 onto the lower cylinder 2. Then the manipulator mounts the lower cylinder 2 upside down on the base 28. During filling, the slide valve on the cover 35 is opened, and the medicine particles fall into the base 28. According to the capacity of the container, the screw conveyor 1 29 or the screw conveyor 2 34 is selected to deliver the medicine particles to the unloading assembly 30 for filling.

[0037] According to the embodiments of the present invention as described above, these embodiments do not describe all the details in detail, nor do they limit the invention to specific embodiments. Obviously, many modifications and changes can be made based on the above description. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can make good use of the present invention and the modified use based on the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A flexible production line for pharmaceutical production, comprising a drying tower and a filling device; characterized in that: The drying tower comprises an upper cylinder (4), a middle cylinder (3), a lower cylinder (2) and a base (1) which are connected in sequence from top to bottom. A feed port is arranged on one side of the middle cylinder (3). An air inlet (16) which is connected to an inner cavity of the middle cylinder (3). An inner cylinder (18) is arranged inside the base (1). An air ring is formed between the outer wall of the inner cylinder (18) and the inner wall of the base (1). A second jacket (24) and a third jacket (25) are sequentially sleeved on the lower cylinder (2) from inside to outside. The bottom of the third jacket (25) is open and the opening profile is adapted to the air ring. The top of the third jacket (25) is connected to the top of the second jacket (24). The bottom of the second jacket (24) is provided with a plurality of groups of air outlets (23) which are connected to the inner cavity of the second jacket (24). The air outlets (23) are provided on the bottom of the second jacket (24). 23) is covered with a layer of breathable and waterproof membrane, the direction of the air outlet (23) is tangent to the side wall of the jacket two (24); the inner cavities of the jacket two (24) and the jacket three (25) are both provided with a plurality of groups of support plates (22), the lower end of the inner part of the jacket two (24) is provided with a plurality of groups of surrounding air guide plates (21), the position of the air guide plates (21) is higher than the position of the air outlet (23), a stirring device (20) is installed at the bottom of the lower cylinder (2), the input end of the stirring device (20) passes through the bottom wall of the lower cylinder (2) through a mechanical seal, a driving motor (17) with an output shaft facing upward is installed inside the inner cylinder (18), the output shaft of the driving motor (17) passes through the top wall of the inner cylinder (18) and is spline-connected to the input end of the stirring device (20); The upper cylinder (4) and the middle cylinder (3) are separated by a bottom plate (10) with holes, the inner cavity of the upper cylinder (4) is divided into two separation chambers by a partition (14) vertically connected to the bottom plate (10), each of the separation chambers is equipped with a separation component (5) connected to the holes, one side of the upper cylinder (4) is provided with an exhaust port (7) respectively connected to the separation chambers, and one end of the exhaust port (7) is provided with an electric control valve (6); The separation assembly (5) comprises a top plate (12), a cylinder (15) and a plurality of collection bags (11); the lower ends of the collection bags (11) are fixed to the bottom plate (10), and the lower end openings of the collection bags (11) correspond one to one with the holes; the top ends of all the collection bags (11) are fixed to the top plate (12); one end of the cylinder (15) is hinged to the bottom plate (10), and the other end of the cylinder (15) is hinged to the top plate (12); and a guide rod (13) passing through the top plate (12) is provided at the inner top of the upper cylinder (4); The filling equipment comprises a frame (32), a conveyor belt (31) is mounted on the frame (32), a support column (33) is arranged on one side of the frame (32), a base (28) for docking the lower cylinder (2) is arranged on the top of the support column (33), and a material discharge assembly (30) facing the conveyor belt (31) is connected to the lower end of the base (28), after the drying tower has finished drying the material, the clamp (27) is removed and the middle cylinder (3) is turned over, and the lower cylinder (2) is taken out by a robot and mounted on the base (28) by means of a cover (35), and a slide valve is arranged on the cover (35); The unloading end of the base (28) forms two unloading ports through a dividing plate (36), and the top of the unloading component (30) is provided with two feeding ports, one of which is connected to one of the feeding ports through a screw conveyor (29), and the other unloading port is connected to the other feeding port through a screw conveyor (34). The diameter and pitch of the screw conveyor (34) are smaller than those of the screw conveyor (29), so as to achieve different unloading amounts.

2. The flexible production line for pharmaceutical production according to claim 1, characterized in that: The outer side of the inner cylinder (18) is provided with a jacket (19) whose interior is evacuated to form a closed environment.

3. The flexible production line for pharmaceutical production according to claim 1, characterized in that: A jacket 1 (19) is provided on the outer side of the inner cylinder (18); a refrigerant outlet is provided on the top side of the jacket 1 (19) and passes through the side wall of the base (1); and a refrigerant inlet is provided on the bottom side of the jacket 1 (19) and passes through the side wall of the base (1).

4. The flexible production line for pharmaceutical production according to claim 1, characterized in that: A material pipe (8) extending into the inner cavity of the middle cylinder (3) is provided on one side of the middle cylinder (3), and a sprayer (9) facing the lower cylinder (2) is provided at the end of the material pipe (8).

5. The flexible production line for pharmaceutical production according to claim 1, characterized in that: The upper cylinder (4), the middle cylinder (3), the lower cylinder (2) and the base (1) are respectively detachably connected via a clamp (27); a rotating shaft (26) is fixedly mounted on one side of the upper cylinder (4) via a mounting seat; a supporting seat is provided on one side of the middle cylinder (3); and the lower end of the rotating shaft (26) is rotatably connected to the supporting seat.

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