Preparation method for processing insoluble healthy raw materials into water-dispersible microcapsules

Abstract

The invention relates to a water-dispersible microcapsule processed from insoluble large healthy raw materials and a preparation method thereof, and belongs to the technical field of medicine production. The water-dispersible microcapsule is prepared from the following raw materials in parts by weight: 1-25 parts by weight of soybean protein isolate or 1-46 parts by weight of whey protein isolate, 1-13 parts by weight of modified starch, 3-35 parts by weight of Arabic gum, 1-48 parts by weight of beta cyclodextrin or maltodextrin and 0.1-0.4 part by weight of an acidity regulator, the health-care food is prepared from the following raw materials in parts by weight: 1-3 parts of a sweetening agent, 0-1.5 parts of essence, 0-4 parts of an antioxidant and 1-35 parts of insoluble healthy raw materials, warm water dispersion of indissolvable medicine raw materials such as hexadecanamide ethanol, resveratrol, curcumin, xanthophyll and coenzyme Q10 can be achieved, and application ways are greatly enriched. The microencapsulated product prepared by the path of the invention is uniform and consistent in content, the dispersibility in water is improved, the bioavailability of large healthy raw materials is greatly improved, no organic reagent is adopted in the whole preparation process, and the production process is safe and guaranteed.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical production, and in particular to a water-dispersible microcapsule made from poorly soluble health raw materials and a preparation method thereof. Background Art

[0002] Insoluble health raw materials include insoluble drugs such as palmitoylethanolamide, resveratrol, curcumin, lutein, etc., so they cannot be directly made into water-dispersible drugs. The current solution is to add insoluble health raw materials into high-temperature edible oil for dispersion, and then embed them with high-molecular emulsifying materials such as sodium starch glycolate, sodium caseinate or gum arabic to obtain water-dispersible microcapsule powder.

[0003] However, the above methods have defects: oil will inevitably oxidize under high temperature conditions to produce oxidation products that are harmful to the human body, or the microcapsule powder contains a large amount of oil, resulting in poor solubility, or the core material has limited solubility in edible oil, resulting in uneven distribution of effective ingredients and poor encapsulation effect.

[0004] Therefore, it is necessary to develop a water-dispersible microcapsule made from poorly soluble health raw materials and a preparation method thereof to solve the above problems. Summary of the invention

[0005] The purpose of the present invention is to provide a water-dispersible microcapsule processed from a poorly soluble health raw material and a preparation method thereof.

[0006] In order to achieve the above object, the present invention provides the following technical solutions: A water-dispersible microcapsule made from an insoluble healthy raw material, comprising the following raw materials in parts by weight: 1-25 parts by weight of soy protein isolate or 1-46 parts by weight of whey protein isolate, 1-13 parts by weight of modified starch, 3-35 parts by weight of gum arabic, 1-48 parts by weight of beta-cyclodextrin or maltodextrin, 0.1-0.4 parts by weight of an acidity regulator, 0.1-0.9 parts by weight of a sweetener, 0-1.5 parts by weight of a flavor, 0-4 parts by weight of an antioxidant, and 1-35 parts by weight of an insoluble healthy raw material; Among them, the insoluble health raw materials include: palmitoylethanolamide, resveratrol, curcumin, lutein, and coenzyme Q10.

[0007] Furthermore, the acidity regulator includes: citric acid, sodium citrate, potassium citrate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, sodium tripolyphosphate, and sodium hexametaphosphate.

[0008] Furthermore, the flavors include: blueberry flavor, sweet orange flavor, coconut flavor, vanilla flavor, milk flavor, peach flavor, and grapefruit flavor.

[0009] Furthermore, the sweeteners include: sucralose, acesulfame potassium, steviol glycosides, monk fruit extract, monopotassium glycyrrhizinate, tripotassium glycyrrhizinate, aspartame, and inulin.

[0010] Furthermore, the modified starch includes: sodium octenyl succinate starch from corn, sodium octenyl succinate starch from cassava, and sodium octenyl succinate starch from potato.

[0011] Furthermore, the antioxidants include: vitamin C, sodium ascorbate, calcium ascorbate, sodium D-isoascorbate, vitamin E, ascorbyl palmitate, tert-butylhydroquinone, bamboo leaf flavonoids, carnosic acid, tea polyphenols, tea polyphenol palmitate, and phospholipids.

[0012] The present invention also provides a method for preparing water-dispersible microcapsules made from the above-mentioned poorly soluble health raw materials, comprising the following steps: S1. Weigh 1-25 parts by weight of soy protein isolate or 1-46 parts by weight of whey protein isolate, 1-13 parts by weight of modified starch, 3-35 parts by weight of gum arabic, 1-48 parts by weight of β-cyclodextrin or maltodextrin, 0.1-0.4 parts by weight of acidity regulator, 0.1-0.9 parts by weight of sweetener, 0-1.5 parts by weight of flavor, and 0-4 parts by weight of antioxidant, and disperse by shearing or stirring in pure water at 40-60° C. at a shear rate of 1000-10000 rpm for a shear time of 10-30 min until completely dissolved to obtain a dispersed phase. S2, weighing 1-35 parts by weight of insoluble health raw material powder as the core material phase; S3, mixing the dispersed phase obtained in step S1 and the core material phase weighed in step S2, and controlling the temperature of the mixed materials to 45-60° C., and stirring and mixing for 10-40 minutes; S4, shearing the mixed material in step S3, with a shearing speed of 3000-20000 rpm and a shearing time of 10-35 min; S5, conveying the material obtained after shearing in step S4 to a high-speed grinder for grinding for 1 to 5 hours at a grinding speed of 1000 to 10000 rpm, while controlling the material temperature at 20 to 65° C., and stopping grinding when the particle size is less than 850 nm; S6. The material ground in step S5 is subjected to ultra-high pressure homogenization, and the material temperature is controlled at 45-65° C. The pressure of the high-pressure homogenization is: the homogenization pressure is 60-300 MPa, and the homogenization is performed 1-2 times. After ultra-high pressure homogenization, the particle size is reduced to within 500 nm, and then dried; a water-dispersible microcapsule processed from a poorly soluble health raw material is obtained.

[0013] Preferably, the drying method of step S6 is spray drying, specifically, the air inlet temperature is 160°C and the air outlet temperature is 90°C. The beneficial effects of the present invention are: The water-dispersible microcapsules processed from the poorly soluble health raw materials provided by the present invention are prepared by mixing, shearing, grinding and ultra-high pressure homogenization of the dispersed phase and the core material phase in a specific proportion. The prepared water-dispersible microcapsules have uniform content, improve the water dispersibility of the poorly soluble health medicine powder, and greatly improve the bioavailability of the drug. No organic reagents are used in the entire preparation process, and the production process is safe and guaranteed.

[0014] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The present invention is a process flow chart for preparing water-dispersible microcapsules made from poorly soluble health raw materials. DETAILED DESCRIPTION

[0016] The technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] The present invention discloses a water-dispersible microcapsule processed from a poorly soluble health raw material and a preparation method thereof. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve it. It is particularly important to point out that all similar substitutions and modifications are obvious to those skilled in the art, and they are all deemed to be included in the present invention. The preparation method and application of water-dispersible microcapsules processed from poorly soluble health raw materials described in the present invention have been described through embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications described herein without departing from the content, spirit and scope of the present invention to realize and apply the technology of the present invention.

[0018] Unless otherwise specified, the health ingredients used in the specific embodiments of the present invention are all raw materials of the same source and quality, and the preparation processes and test conditions remain the same except for the necessary differences.

[0019] The following is a further description of the preparation method of water-dispersible microcapsules processed from a poorly soluble health raw material provided by the present invention. Example

[0020] (1) Preparation of dispersed phase: Weigh 20 parts by weight of soy protein isolate, 5.6 parts by weight of modified starch, 0.15 parts by weight of citric acid, 0.2 parts by weight of sucralose, 34 parts by weight of maltodextrin, 0.05 parts by weight of milk flavor, and 15 parts by weight of gum arabic, and disperse by shearing or stirring in 52°C pure water at a shear speed of 3000 rpm for 20 min. Set aside after complete dissolution.

[0021] (2) Weighing the core material: Weigh 7 parts by weight of superfine palmitoylethanolamide powder and set aside.

[0022] (3) Mixing: Mix the dispersed phase and the core material and stir for 15 minutes to obtain a mixed material.

[0023] (4) High-speed shearing: The mixed material is subjected to high-speed shearing, with a shearing speed of 3000 rpm and a shearing time of 24 minutes.

[0024] (5) High-speed grinding: The sheared mixed material is ground at high speed, with a grinding speed of 2000 rpm, a grinding time of 3 hours, and a grinding temperature of 44°C. After grinding, the particle size of the material is reduced to 680 nm.

[0025] (6) Ultra-high pressure homogenization and drying: The ground material is subjected to ultra-high pressure homogenization, the material temperature is controlled at 52-62°C, the homogenization pressure is 100Mpa, and the particle size of the homogenized material is reduced to 348nm, which meets the requirements. Then, spray drying is started: the inlet air temperature is 178°C, and the outlet air temperature is 86°C, and palmitoylethanolamide microcapsule powder is obtained.

[0026] Evaluation standard for dispersibility in water: add 1g of palmitoylethanolamide microcapsule powder to 100g of 50℃ warm water and stir gently for 5 minutes. If it is clear or evenly dispersed, it has good dispersibility, otherwise it has poor dispersibility.

[0027] Dispersibility in water and effective content of samples: Add 1g of the above-obtained palmitoylethanolamide microcapsule powder to 100g of 50℃ warm water, stir gently for 5 minutes, and it will become clear and transparent. The content was tested by high performance liquid chromatography. The content of the samples in three different time periods was 8.01%, 8.09%, and 7.95%, respectively, while the designed content was 8.5%, indicating that the product content was evenly distributed. Example

[0028] (1) Prepare dispersed phase: Weigh 24.3 parts by weight of soy protein isolate, 10 parts by weight of modified starch, 30 parts by weight of gum arabic, 0.1 parts by weight of citric acid, 0.3 parts by weight of acesulfame potassium, and 7 parts by weight of β-cyclodextrin, and disperse by shearing or stirring in 50°C pure water at a shear rate of 3000-10000 rpm for 13 min. Dissolve completely and set aside for use.

[0029] (2) Weighing the core material: Weigh 18 parts by weight of resveratrol ultrafine powder and set aside.

[0030] (3) Mixing: Mix the dispersed phase and the core material and stir for 15 minutes to obtain a mixed material.

[0031] (4) High-speed shearing: The mixed material is subjected to high-speed shearing at a shearing speed of 3000 rpm and a shearing time of 20 minutes.

[0032] (5) High-speed grinding: The sheared mixed material is ground at high speed, with a grinding speed of 3000 rpm, a grinding temperature of 50°C, and a grinding time of 2 h.

[0033] (6) Ultrahigh pressure homogenization and drying: The ground material is subjected to ultrahigh pressure homogenization, the material temperature is controlled at 45-50°C, the ultrahigh pressure homogenization pressure is 130MPa, and the particle size of the material is reduced to 290nm after ultrahigh pressure homogenization. Next, spray drying is performed: the inlet air temperature is 160°C and the outlet air temperature is 84°C to obtain resveratrol microcapsule powder.

[0034] Dispersibility in water and effective content of samples: Add 1g of the above-obtained resveratrol microcapsule powder to 100g of 50℃ warm water, stir gently for 5 minutes, and it will become clear and transparent. The content was tested by high performance liquid chromatography. The content of the samples in three different time periods was 21.2%, 20.4%, and 20.9%, respectively, while the designed content was 20%, indicating that the product content was evenly distributed. Example

[0035] (1) Prepare dispersed phase: weigh 20 parts by weight of whey protein isolate, 4 parts by weight of modified starch, 6 parts by weight of gum arabic, 0.1 parts by weight of citric acid, 0.13 parts by weight of stevioside, and 2 parts by weight of β-cyclodextrin, and disperse by shearing or stirring in 54°C pure water at a shear speed of 3000 rpm for 15 min. Set aside after complete dissolution.

[0036] (2) Weighing the core material: Weigh 0.5 parts by weight of ultrafine curcumin powder and set aside.

[0037] (3) Mixing: Mix the dispersed phase and the core material, stir and mix for 30 minutes to obtain a mixed material.

[0038] (4) High-speed shearing: The mixed materials are subjected to high-speed shearing at a shearing speed of 3000 rpm and a shearing time of 15 minutes.

[0039] (5) High-speed grinding: The sheared material is ground at high speed, with a grinding speed of 1000 rpm, a grinding temperature of 55 °C, and a grinding time of 4 h.

[0040] (6) Ultrahigh pressure homogenization and drying: The ground material is subjected to ultrahigh pressure homogenization, the material temperature is controlled at 50-60°C, the ultrahigh pressure homogenization pressure is 60MPa, and the particle size of the material is reduced to 418nm after ultrahigh pressure homogenization. Then, freeze drying is performed at a freeze drying temperature of -40°C and a freeze drying time of 3 hours to obtain curcumin microcapsule powder.

[0041] Dispersibility in water and effective content of samples: Add 1g of the above-obtained curcumin microcapsule powder to 100g of 50℃ warm water, stir gently for 5 minutes, and it can be evenly dispersed. The content was tested by high performance liquid chromatography. The content of the samples in three different time periods was 1.4%, 1.5%, and 1.7%, respectively, while the designed content was 1.5%, indicating that the product content was evenly distributed. Example

[0042] (1) Prepare dispersed phase: Weigh 1 part by weight of whey protein isolate, 54 parts by weight of modified starch, 1 part by weight of gum arabic, 0.1 part by weight of citric acid, 0.2 parts by weight of stevioside, 29 parts by weight of maltodextrin, and 3 parts by weight of sodium D-isoascorbate, and disperse by shearing or stirring in 51°C pure water at a shear speed of 3000 rpm for 25 min. Set aside after complete dissolution.

[0043] (2) Weighing the core material: Weigh 4.65 parts by weight of lutein powder and set aside.

[0044] (3) Mixing: Mix the dispersed phase and the core material, stir and mix for 30 minutes to obtain a mixed material.

[0045] (4) High-speed shearing: The mixed materials are subjected to high-speed shearing at a shearing speed of 3000 rpm and a shearing time of 15 minutes.

[0046] (5) High-speed grinding: The sheared material is ground at high speed, with a grinding speed of 3000 rpm, a grinding temperature of 30°C, and a grinding time of 2.5 h.

[0047] (6) Ultrahigh pressure homogenization and drying: The ground material is subjected to ultrahigh pressure homogenization, the material temperature is controlled at 50-60°C, the ultrahigh pressure homogenization pressure is 90MPa, and the particle size of the material is reduced to 418nm after ultrahigh pressure homogenization. Next, spray drying is performed: the inlet air temperature is 150°C and the outlet air temperature is 80°C to obtain lutein microcapsule powder.

[0048] Dispersibility in water and effective content of samples: Add 1g of the above-obtained lutein microcapsule powder to 100g of 50℃ warm water and stir gently for 5 minutes to evenly disperse. The content was tested by HPLC. The content of samples in three different time periods was 4.4%, 4.5%, and 4.7%, respectively, while the designed content was 5%, indicating that the product content was evenly distributed. Example

[0049] (1) Prepare dispersed phase: weigh 3 parts by weight of soy protein isolate, 34 parts by weight of modified starch, 14 parts by weight of gum arabic, 0.1 parts by weight of citric acid, 0.25 parts by weight of sucralose, 48 parts by weight of maltodextrin, and 2 parts by weight of sodium D-isoascorbate, and disperse them by shearing or stirring in pure water at 45°C at a shear speed of 3000 rpm for 25 min. Set aside after complete dissolution.

[0050] (2) Weighing the core material: Weigh 18.3 parts by weight of coenzyme Q10 powder and set aside.

[0051] (3) Mixing: Mix the dispersed phase and the core material and stir for 30 minutes to obtain a mixed material.

[0052] (4) High-speed shearing: The mixed material is subjected to high-speed shearing at a shearing speed of 3000 rpm and a shearing time of 20 minutes.

[0053] (5) High-speed grinding: The sheared mixed material is ground at high speed, with a grinding speed of 3000 rpm, a grinding temperature of 42°C, and a grinding time of 1.5 h.

[0054] (6) Ultrahigh pressure homogenization and drying: The ground material is subjected to ultrahigh pressure homogenization, the material temperature is controlled at 55-65°C, the ultrahigh pressure homogenization pressure is 85MPa, and the particle size of the material is reduced to 360nm after ultrahigh pressure homogenization. Next, spray drying is performed: the inlet air temperature is 160°C and the outlet air temperature is 90°C to obtain coenzyme Q10 microcapsule powder.

[0055] Dispersibility in water and effective content of samples: Add 1g of the above-obtained coenzyme Q10 microcapsule powder to 100g of 50℃ warm water, stir gently for 5 minutes, and it can be evenly dispersed. The content was tested by high performance liquid chromatography. The content of the samples in three different time periods was 15.0%, 15.5%, and 15.3%, respectively, while the designed content was 15%, indicating that the product content was evenly distributed.

[0056] Comparative Example 1 A method for preparing resveratrol microcapsules comprises the following steps: (1) dissolving resveratrol in an ethanol aqueous solution with a volume concentration of 75% as a solvent, adding an emulsifier, starch sugar fatty acid ester, passing through a colloid mill at 25° C. for 30 minutes, and mixing to prepare a core material solution, wherein the mass ratio of the resveratrol, the solvent, and the emulsifier is 1:2:5; (2) adding water to chitosan and stirring at 40° C. for 1.5 hours to swell and disperse the chitosan to prepare a wall material solution, wherein the mass ratio of chitosan to water is 1:10; (3) The core material solution was added to the wall material solution at a mass ratio of 1:20 at 40° C. to obtain a mixed solution, which was homogenized with a colloid mill to form a white emulsion, and a curing agent was added. The mixture was homogenized with a colloid mill for 45 minutes, and resveratrol microcapsules with good dispersibility were obtained after spray drying. The curing agent was a solution composed of vanillin, sodium alginate and water in a mass ratio of 10:10:50.

[0057] Dispersibility in water and effective content of samples: 1g of the above-obtained resveratrol microcapsule powder was added to 100g of 50℃ warm water and stirred lightly for 5 minutes. It was not clear and transparent. The content was tested by HPLC. The content of the samples in three different time periods was 5.2%, 4.5%, and 3.3%, respectively, while the designed content was 6.43%, indicating that the content of the product was unevenly distributed.

[0058] Comparative Example 2 A method for preparing lutein microcapsules comprises the following steps: (1) Dissolve 0.6 g of lutein in 150 ml of 95 wt% edible alcohol to obtain a core material solution; mix 18 g of octenyl succinate starch ester, 8 g of polyvinyl pyrrolidone, and 900 mL of deionized water, and then stir at 60° C. and 120 r / min for 2 h to obtain a wall material solution; (2) adding the core material solution to the wall material solution, and then shearing and emulsifying at a speed of 8000 r / min for 3 min to obtain a coarse suspension, and then homogenizing once at a pressure of 30 MPa to obtain a nanosuspension; (3) The nanosuspension is spray-dried to obtain lutein microcapsules. The conditions during the spray-drying process are: inlet temperature of 170°C, outlet temperature of 90°C, and feed rate of 15 ml / min.

[0059] Dispersibility in water and effective content of samples: 1g of the above-obtained lutein microcapsule powder was added to 100g of 50℃ warm water and stirred slightly for 5 minutes, but it could not be evenly dispersed. The content was tested by HPLC, and the sample contents at three different time periods were 1.4%, 0.8%, and 0.5%, respectively, while the designed content was 2.2%, indicating that the product content was unevenly distributed.

[0060] From the dispersibility in water and the effective content of the sample, it can be seen that the powder obtained by the method of the present invention has a small particle size of the core material phase and the dispersed phase mixed solution, the core material can be effectively wrapped in the microcapsule cavity formed by the dispersed phase, the dispersibility in water is good, and the content distribution is even.

[0061] However, in the water dispersibility and effective content test of the sample by the comparative method, the particle size of the mixed solution of the core material phase and the dispersed phase is large, the core material cannot be effectively wrapped in the microcapsule cavity formed by the dispersed phase, the water dispersibility is poor, and the content distribution is uneven.

[0062] In summary, the present invention provides a water-dispersible microcapsule processed from a poorly soluble health raw material and a preparation method thereof, which can achieve warm water dispersion of poorly soluble drug raw materials such as palmitoylethanolamide, resveratrol, curcumin, lutein, coenzyme Q10, etc., greatly enriching the application pathways. The present invention further defines the ratio between the raw materials, and the raw materials are reasonably proportioned to enhance the synergistic enhancement effect between the raw materials. The microencapsulated product prepared by the present invention has uniform content, improved dispersibility in water, greatly improved the bioavailability of the big health raw materials, and no organic reagents are used in the entire preparation process, so the production process is safe and guaranteed.

[0063] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0064] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A water-dispersible microcapsule made from a poorly soluble health raw material, characterized in that: The invention is prepared from the following raw materials in parts by weight: 1-25 parts by weight of soy protein isolate or 1-46 parts by weight of whey protein isolate, 1-13 parts by weight of modified starch, 3-35 parts by weight of gum arabic, 1-48 parts by weight of beta-cyclodextrin or maltodextrin, 0.1-0.4 parts by weight of acidity regulator, 0.1-0.9 parts by weight of sweetener, 0-1.5 parts by weight of flavor, 0-4 parts by weight of antioxidant, and 1-35 parts by weight of insoluble health raw materials; Among them, the insoluble health raw materials include: palmitoylethanolamide, resveratrol, curcumin, lutein, and coenzyme Q10.

2. The water-dispersible microcapsules made from the poorly soluble health raw materials according to claim 1, characterized in that: The acidity regulator includes: citric acid, sodium citrate, potassium citrate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, sodium tripolyphosphate, and sodium hexametaphosphate.

3. The water-dispersible microcapsules made from the poorly soluble health raw materials according to claim 1, characterized in that: The flavors include: blueberry flavor, sweet orange flavor, coconut flavor, vanilla flavor, milk flavor, peach flavor, and grapefruit flavor.

4. The water-dispersible microcapsules made from the poorly soluble health raw materials according to claim 1, characterized in that: The sweeteners include: sucralose, acesulfame potassium, stevioside, monk fruit extract, monopotassium glycyrrhizinate, tripotassium glycyrrhizinate, aspartame, and inulin.

5. The water-dispersible microcapsules made from the poorly soluble health raw materials according to claim 1, characterized in that: The modified starch includes: sodium octenyl succinate starch from corn, sodium octenyl succinate starch from cassava and sodium octenyl succinate starch from potato.

6. The water-dispersible microcapsules made from the poorly soluble health raw materials according to claim 1, characterized in that: The antioxidants include: vitamin C, sodium ascorbate, calcium ascorbate, sodium D-isoascorbate, vitamin E, ascorbyl palmitate, tert-butylhydroquinone, bamboo leaf flavonoids, carnosic acid, tea polyphenols, tea polyphenol palmitate, and phospholipids.

7. A method for preparing water-dispersible microcapsules made from the poorly soluble health raw materials as claimed in any one of claims 1 to 6, characterized in that: The steps include: S1. Weigh 1-25 parts by weight of soy protein isolate or 1-46 parts by weight of whey protein isolate, 1-13 parts by weight of modified starch, 3-35 parts by weight of gum arabic, 1-48 parts by weight of β-cyclodextrin or maltodextrin, 0.1-0.4 parts by weight of acidity regulator, 0.1-0.9 parts by weight of sweetener, 0-1.5 parts by weight of flavor, and 0-4 parts by weight of antioxidant, and disperse by shearing or stirring in pure water at 40-60° C. at a shear rate of 1000-10000 rpm for a shear time of 10-30 min until completely dissolved to obtain a dispersed phase. S2, weighing 1-35 parts by weight of insoluble health raw material powder as the core material phase; S3, stirring and mixing the dispersed phase and the core material phase, controlling the temperature at 45-60° C. during the mixing process, and the mixing process lasts for 10-40 minutes; S4, shearing the mixed material in step S3, with a shearing speed of 3000-20000 rpm and a shearing time of 10-35 min; S5, conveying the material obtained after shearing in step S4 to a high-speed grinder for grinding for 1 to 5 hours at a grinding speed of 1000 to 10000 rpm, controlling the material temperature at 20 to 65° C. during the grinding process, and stopping the grinding when the particle size is less than 850 nm; S6. The material ground in step S5 is subjected to ultra-high pressure homogenization. The conditions of ultra-high pressure homogenization are: temperature 45-65° C., pressure 60-300 MPa, and homogenization 1-2 times. After ultra-high pressure homogenization, the particle size of the material is reduced to less than 500 nm, and dried to obtain water-dispersible microcapsules processed from insoluble health raw materials.

8. The method for preparing water-dispersible microcapsules made from poorly soluble health raw materials according to claim 7, characterized in that: The drying method of step S6 is spray drying, and the drying conditions are an inlet air temperature of 160°C and an outlet air temperature of 90°C.

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