Pharmaceutical composition for treating yin depletion or anal depletion of cattle and sheep and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating yin depletion or anal depletion of cattle and sheep and a preparation method, the composition comprises the following raw materials: 100 ml of veterinary procaine injection, 4-8 g of alum and 0.5-1.5 ml of veterinary epinephrine injection, and the three raw materials cooperate to significantly improve the treatment effect; the medicine used locally directly acts on the prolapsed part, and can quickly relieve pain, diminish swelling and promote restoration. In addition, secondary injury and infection caused by traditional reduction are avoided. The recovery can be generally realized in 2-3 days after the medicine is taken, and the treatment period is greatly shortened; the preparation method of the composition is simple in process and easy to popularize, the composition can be prepared only by mixing the three components in proportion and heating and dissolving the three components, complex chemical synthesis is not needed, the requirements for equipment and operation technologies are not high, and the composition is convenient to popularize and apply in the first-line culture line.

Description

Technical Field

[0001] The invention belongs to the technical field of animal husbandry medicines, and particularly relates to a pharmaceutical composition for treating vaginal prolapse or anal prolapse of cattle and sheep and a preparation method thereof. Background Art

[0002] Vaginal or anal prolapse of cattle and sheep refers to the vagina or anus turning over and protruding outside the vulva or anus. It is one of the common obstetric diseases of cattle and sheep, especially in elderly and multiparous cattle and sheep. It is often malnourished in the late pregnancy, increased confinement, greatly reduced exercise, loose ligaments, weak constitution, and oversized fetuses. Its symptoms are that the vagina and uterus of cows and ewes prolapse outside the vulva, forming a red prolapse the size of an eggplant. If it lasts for a long time, the prolapsed part is prone to congestion and hematoma, and may cause secondary massive bleeding and sepsis when damaged and infected. If not treated in time, it may be infected with bacteria or viruses, causing diseases and endangering life, causing certain economic losses to cattle and sheep farmers. Vaginal or anal prolapse of cattle and sheep is one of the common diseases in veterinary obstetrics. In addition to the above reasons, the occurrence of vaginal or anal prolapse of cattle and sheep is also related to genetic factors, endocrine disorders, environmental factors and improper delivery. As the disease progresses, the prolapsed material may become edematous, congested, eroded, or even necrotic, and may lead to complications such as endometritis and intestinal obstruction. The traditional method of repositioning is to manually force the prolapsed part into the vagina and then suture it. This is very likely to cause recurrence, and repeated operations may cause infection due to bacteria from the veterinarian's hands or instruments, seriously affecting the reproductive performance of cattle and sheep. Summary of the invention

[0003] In view of the defects and problems existing in the existing treatment of vulvar prolapse or anal prolapse of cattle and sheep, the present invention provides a pharmaceutical composition and a preparation method for treating vulvar prolapse or anal prolapse of cattle and sheep, aiming to provide a compound preparation for the treatment of vulvar prolapse or anal prolapse of cattle and sheep with good efficacy, convenient use, and economical and practical properties, effectively overcoming the shortcomings of traditional manipulations and providing a better prevention and treatment plan for the breeding industry.

[0004] The solution adopted by the present invention to solve the technical problem is: a pharmaceutical composition for treating vaginal prolapse or anal prolapse of cattle and sheep, the composition comprising raw materials in the following proportions: 100 ml of veterinary procaine injection, 4 g-8 g of alum and 0.5 ml-1.5 ml of veterinary adrenaline injection.

[0005] The specification of the veterinary procaine injection is 10ml:0.2g.

[0006] The specification of the veterinary adrenaline injection is 1ml:1mg.

[0007] The composition comprises raw materials in the following proportions: 100 ml of veterinary procaine injection, 6 g of alum and 1 ml of veterinary adrenaline injection.

[0008] A method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse of cattle and sheep comprises the following steps:

[0009] Step 1: Take 100 ml of veterinary procaine injection and place it in a container;

[0010] Step 2, add 4g-8g of alum into a container and mix with veterinary procaine;

[0011] Step 3, heating the mixture prepared in step 2 to 40-50° C., stirring evenly until alum is dissolved;

[0012] Step 4: Take 0.5ml-1.5ml of veterinary epinephrine injection and mix it into the solution in step 3, and stir evenly.

[0013] The specification of the veterinary procaine injection in step 1 is 10ml:0.2g.

[0014] The specification of the veterinary adrenaline injection in step 4 is 1 ml: 1 mg.

[0015] Beneficial effects of the present invention: The pharmaceutical composition and preparation method for treating vaginal or anal prolapse of cattle and sheep provided by the present invention combine the complementary advantages of three components, namely, procaine, alum and adrenaline. Procaine provides a rapid and effective local anesthetic analgesic effect, which can relieve the pain and discomfort of prolapse of cattle and sheep; alum has astringent and hemostatic effect, which can help the prolapsed part to reduce swelling and reset; adrenaline can prolong the anesthesia time and avoid pain rebound after the drug effect disappears. The three components work together to significantly improve the treatment effect; local use of drugs directly acts on the prolapsed part, which can quickly relieve pain, reduce swelling and promote reset. And it will not cause secondary damage and infection like traditional manual reduction. Generally, it can be recovered in 2-3 days after medication, and the treatment cycle is greatly shortened; the preparation method is simple and easy to promote. The preparation of the composition only requires mixing the three components in proportion and heating and dissolving, without complex chemical synthesis, and does not require high equipment and operation technology, which is convenient for promotion and application in the front line of breeding. Veterinarians or breeders can master it after simple training. DETAILED DESCRIPTION

[0016] The present invention is further described below in conjunction with embodiments.

[0017] Example

[0018] The present embodiment provides a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, the composition comprising raw materials in the following proportions: 100 ml of veterinary procaine injection, 4 g-8 g of alum and 0.5 ml-1.5 ml of veterinary epinephrine injection, wherein the specification of the veterinary epinephrine injection is 1 ml:1 mg, and the specification of the veterinary procaine injection is 10 ml:0.2 g.

[0019] The present embodiment provides a method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, comprising the following steps:

[0020] Step 1: Take 100 ml of veterinary procaine injection and place it in a container, and the specification of the veterinary procaine injection is 10 ml: 0.2 g.

[0021] Step 2: Take 4g-8g of alum and add it into a container and mix it with veterinary procaine.

[0022] Step 3: Heat the mixture prepared in step 2 to 40-50° C. and stir evenly until the alum is dissolved.

[0023] Step 4: Take 0.5ml-1.5ml of veterinary adrenaline injection and mix it into the solution in step 3. Stir well and it is ready for use. The specification of veterinary adrenaline injection is 1ml:1mg.

[0024] Example 1

[0025] The present embodiment provides a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, the composition comprising raw materials in the following proportions: 100 ml of veterinary procaine injection, 4 g of alum and 0.5 ml of veterinary epinephrine injection; wherein the specification of the veterinary epinephrine injection is 1 ml:1 mg, and the specification of the veterinary procaine injection is 10 ml:0.2 g.

[0026] The present embodiment provides a method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, comprising the following steps:

[0027] Step 1: Take 100 ml of veterinary procaine injection and place it in a container, and the specification of the veterinary procaine injection is 10 ml: 0.2 g.

[0028] Step 2: Take 4 g of alum and add it into a container and mix it with veterinary procaine.

[0029] Step 3: Heat the mixture prepared in step 2 to 40-50° C. and stir evenly until the alum is dissolved.

[0030] Step 4: Take 0.5 ml of veterinary adrenaline injection and mix it into the solution in step 3. Stir well and it is ready for use. The specification of veterinary adrenaline injection is 1 ml:1 mg.

[0031] When using, the dosage of the drug composition is determined according to the difference between cattle and sheep and the size of the prolapsed surface. First, the drug composition is injected into the Houhai acupoint of cattle and sheep with a syringe, and then the drug composition is intradermally injected into the prolapsed part at multiple points. The injection volume of the Houhai acupoint is 10-15ml for cattle and 3-5ml for sheep. The injection volume of the prolapsed part is 1ml per 25 square centimeters. The third step is to slowly send the prolapsed part back into the body 5 minutes after the injection. If it recurs the next day, inject it again.

[0032] Example 2

[0033] The present embodiment provides a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, the composition comprising raw materials in the following proportions: 100 ml of veterinary procaine injection, 6 g of alum and 1 ml of veterinary epinephrine injection; wherein the specification of the veterinary epinephrine injection is 1 ml:1 mg, and the specification of the veterinary procaine injection is 10 ml:0.2 g.

[0034] The present embodiment provides a method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, comprising the following steps:

[0035] Step 1: Take 100 ml of veterinary procaine injection and place it in a container, and the specification of the veterinary procaine injection is 10 ml: 0.2 g.

[0036] Step 2: Take 6 g of alum and add it into a container and mix it with veterinary procaine.

[0037] Step 3: Heat the mixture prepared in step 2 to 40-50° C. and stir evenly until the alum is dissolved.

[0038] Step 4: Take 1 ml of veterinary adrenaline injection and mix it into the solution in step 3. Stir well and it is ready for use. The specification of veterinary adrenaline injection is 1 ml:1 mg.

[0039] When using, the dosage of the drug composition is determined according to the difference between cattle and sheep and the size of the prolapsed surface. First, the drug composition is injected into the Houhai acupoint of cattle and sheep with a syringe, and then the drug composition is intradermally injected into the prolapsed part at multiple points. The injection volume of the Houhai acupoint is 10-15ml for cattle and 3-5ml for sheep. The injection volume of the prolapsed part is 1ml per 25 square centimeters. The third step is to slowly send the prolapsed part back into the body 5 minutes after the injection. If it recurs the next day, inject it again.

[0040] Example 3

[0041] The present embodiment provides a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, the composition comprising raw materials in the following proportions: 100 ml of veterinary procaine injection, 8 g of alum and 1.5 ml of veterinary epinephrine injection; wherein the specification of the veterinary epinephrine injection is 1 ml:1 mg, and the specification of the veterinary procaine injection is 10 ml:0.2 g.

[0042] The present embodiment provides a method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, comprising the following steps:

[0043] Step 1: Take 100 ml of veterinary procaine injection and place it in a container, and the specification of the veterinary procaine injection is 10 ml: 0.2 g.

[0044] Step 2: Take 8 g of alum and add it into a container and mix it with veterinary procaine.

[0045] Step 3: Heat the mixture prepared in step 2 to 40-50° C. and stir evenly until the alum is dissolved.

[0046] Step 4: Take 1.5 ml of veterinary adrenaline injection and mix it into the solution in step 3. Stir well and it is ready for use. The specification of veterinary adrenaline injection is 1 ml:1 mg.

[0047] When using, the dosage of the drug composition is determined according to the difference between cattle and sheep and the size of the prolapsed surface. First, the drug composition is injected into the Houhai acupoint of cattle and sheep with a syringe, and then the drug composition is intradermally injected into the prolapsed part at multiple points. The injection volume of the Houhai acupoint is 10-15ml for cattle and 3-5ml for sheep. The injection volume of the prolapsed part is 1ml per 25 square centimeters. The third step is to slowly send the prolapsed part back into the body 5 minutes after the injection. If it recurs the next day, inject it again.

[0048] In comparative example 1, when cattle and sheep have vaginal prolapse or anal prolapse, the prolapsed part is directly inserted into the vagina with hands and then sutured.

[0049] Table 1

[0050]

[0051] As shown in Table 1, the pharmaceutical composition for treating vaginal or anal prolapse of cattle and sheep provided in this embodiment combines the complementary advantages of procaine, alum, and adrenaline. Procaine provides a fast and effective local anesthetic analgesic effect, which can relieve the pain and discomfort of prolapse of cattle and sheep; alum has astringent and hemostatic effect, which can help the prolapsed part to reduce swelling and reset; adrenaline can prolong the anesthesia time to avoid pain rebound after the drug effect wears off. The three cooperate to significantly improve the treatment effect; local use of drugs directly acts on the prolapsed part, which can quickly relieve pain, reduce swelling, and promote reset. And it will not cause secondary damage and infection like traditional manual reduction. It can generally recover in 2-3 days after medication, and the treatment cycle is greatly shortened; its preparation method is simple and easy to promote. The preparation of the composition only requires mixing the three components in proportion and heating and dissolving, without complex chemical synthesis, and does not require high equipment and operating technology, which is convenient for promotion and application in the front line of breeding. Veterinarians or breeders can master it after simple training.

[0052] It should be understood that the above specific embodiments of the present invention are only used to illustrate or explain the principles of the present invention, and do not constitute a limitation of the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. In addition, the appended claims of the present invention are intended to cover all changes and modifications that fall within the scope and boundaries of the appended claims, or the equivalent forms of such scope and boundaries.

Claims

1. A pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, characterized in that: The composition comprises raw materials in the following proportions: 100 ml of veterinary procaine injection, 4 g to 8 g of alum and 0.5 ml to 1.5 ml of veterinary adrenaline injection.

2. The pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep according to claim 1, characterized in that: The specification of the veterinary procaine injection is 10ml:0.2g.

3. The pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep according to claim 1, characterized in that: The specification of the veterinary adrenaline injection is 1ml:1mg.

4. The pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep according to claim 1, characterized in that: The composition comprises raw materials in the following proportions: 100 ml of veterinary procaine injection, 6 g of alum and 1 ml of veterinary adrenaline injection.

5. A method for preparing a pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep, characterized in that: The following steps are involved: Step 1: Take 100 ml of veterinary procaine injection and place it in a container; Step 2, add 4g-8g of alum into a container and mix with veterinary procaine; Step 3, heating the mixture prepared in step 2 to 40-50° C., stirring evenly until alum is dissolved; Step 4: Take 0.5 ml -1.5 ml of veterinary adrenaline injection and mix it into the solution in step 3, and stir evenly.

6. The method for preparing the pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep according to claim 5, characterized in that: The specification of the veterinary procaine injection in step 1 is 10ml:0.2g.

7. The method for preparing the pharmaceutical composition for treating vaginal prolapse or anal prolapse in cattle and sheep according to claim 5, characterized in that: The specification of the veterinary adrenaline injection in step 4 is 1 ml: 1 mg.

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