Traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood and preparation of traditional Chinese medicine composition

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood and a preparation method thereof. The composition is prepared by carefully selecting a plurality of traditional Chinese medicinal materials with the effects of tonifying qi and blood, regulating menstruation and nourishing blood and combining the traditional Chinese medicinal materials according to a specific proportion, and comprises ginseng, codonopsis pilosula, lucid ganoderma, astragalus membranaceus, angelica sinensis, peach kernels, donkey-hide gelatin, longan aril, Chinese dates, Chinese yams, radix polygonati officinalis, fructus lycii, poria cocos, roses and pericarpium citri reticulatae. The traditional Chinese medicine composition is prepared through the processes of extraction, double-effect concentration, filtration, blending and the like through scientific proportioning and a unique processing technology, aims to effectively improve the symptom of scanty menstruation caused by deficiency of qi and blood of women, recover normal menstruation, condition the body and improve the overall health level, has good safety and effectiveness, and is worthy of popularization and application. And a new choice is provided for health management of women. The traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood is safe, small in side effect, efficient, convenient and good in taste.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency and a preparation thereof. Background Art

[0002] In traditional Chinese medicine theory, qi and blood are the basic substances for maintaining human life activities. The symptoms caused by qi and blood deficiency are mainly manifested as scanty menstruation, dark menstrual blood color, excessive blood clots, fatigue, sallow complexion, insomnia and dreaminess. Modern people often suffer from qi and blood deficiency and the above symptoms due to irregular lifestyle, uncontrolled diet, staying up late, lack of exercise, and loss of qi and blood in the body due to wind, cold, dampness and heat. Among them, women's menstrual disorders caused by qi and blood deficiency, especially scanty menstruation, seriously affect physiological health and quality of life. Although Western medicine for regulating qi and blood is effective quickly, it has obvious side effects; functional foods for qi and blood conditioning on the market are safe and have no side effects, but the effect is weak and cannot achieve the ideal therapeutic effect. Traditional Chinese medicine uses a variety of Chinese medicinal materials to replenish qi and blood and regulate menstruation, but the existing Chinese medicine prescriptions have different effects, are inconvenient to take, and have a poor taste. Therefore, it is particularly urgent to develop a safe, low-side-effect, efficient, convenient, and good-tasting Chinese medicine composition for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency. Summary of the invention

[0003] The purpose of the present invention is to provide a Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency, overcome the side effects of existing western medicines and the defects of weak conditioning effects of functional foods on the market, and provide an efficient and convenient treatment plan. The Chinese medicine composition provided by the present invention is made by selecting a variety of Chinese medicinal materials with the effects of replenishing qi and blood, regulating menstruation and nourishing blood, and is made through scientific proportioning and unique processing technology, and utilizes its synergistic effect to achieve the best effect, aiming to effectively improve the symptoms of oligomenorrhea caused by qi and blood deficiency in women, restore normal menstruation, and regulate the body at the same time, improve the overall health level, and is safe, has few side effects, is efficient, convenient, and has a good taste.

[0004] The Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency provided by the present invention is a formula of Luo's Tianjing Dihua Dan, which is a combination of selected monarch, minister, assistant and envoy ingredients under the guidance of traditional Chinese medicine theory and clinical experience. The formula originates from Luo Shichong, an imperial physician in the Daoguang period of the Qing Dynasty. The Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency provided by the present invention strengthens the functions of replenishing qi, replenishing blood, regulating menstruation, calming the mind and strengthening the body.

[0005] The Luo family of traditional Chinese medicine originated from the Daoguang period of the Qing Dynasty. Their ancestor, the imperial physician Luo Shichong, was knowledgeable and his style of using medicine was "accurate, stable, precise, smooth, light and flexible", with remarkable therapeutic effects. He wrote a royal prescription for palace use: Luo's Tianjing Dihua Dan, which uses carefully selected precious medicinal materials from various authentic places of origin, and uses the main, secondary, auxiliary and adjuvant drugs to symptomatically treat scanty menstruation caused by deficiency of Qi and blood, and to achieve the effect of replenishing Qi and blood.

[0006] The present invention provides a Chinese medicine composition for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency. Special ingredients are added to protect the stability of effective ingredients of Chinese medicinal materials without affecting the effects of traditional Chinese medicine formulas. At the same time, the effect of adjusting the taste can be achieved, thereby overcoming the defect that traditional Chinese medicine decoctions are bitter and difficult to swallow.

[0007] The present invention provides a Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency, comprising the following Chinese medicine main ingredients and ingredients in specific weight proportions:

[0008] Main Chinese medicinal materials in specific weight proportions: 15-20 parts of ginseng, 15-20 parts of codonopsis, 15-20 parts of ganoderma lucidum, 15-20 parts of astragalus, 15-20 parts of angelica, 15-20 parts of peach kernel, 15-20 parts of donkey-hide gelatin, 15-20 parts of longan pulp, 8-12 parts of jujube, 7-10 parts of yam, 7-10 parts of polygonatum, 7-10 parts of wolfberry, 7-10 parts of poria, 7-10 parts of rose and 7-10 parts of tangerine peel;

[0009] Ingredients: Licorice extract and citric acid are prepared in a mass ratio of 1-2:2-3. After mixing, the mass ratio with the Chinese medicine raw material is 1-5:99-95.

[0010] The raw materials of the Chinese medicine prescription of the present invention are as follows:

[0011] Ginseng: The root of the plant Panax ginseng is warm in nature, sweet and slightly bitter in taste; it enters the heart meridian, lung meridian, spleen meridian, and kidney meridian. It has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, tonifying spleen and lung, promoting body fluid, and calming the mind. It is mainly used to treat physical weakness and fainting, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and coughing, loss of body fluid and thirst, internal heat and thirst, long-term illness and weakness, palpitations and insomnia, impotence and cold uterus; heart failure, cardiogenic shock.

[0012] Codonopsis: The root of the plants of Campanulaceae, such as Codonopsis pilosula, ...

[0013] Ganoderma: The fruiting body of the Polyporaceae fungi Ganoderma, Ganoderma lucidum, etc., is sweet and flat in taste; it enters the heart, lung, liver, and kidney meridians. It has the effects of replenishing qi and calming the mind, relieving cough and relieving asthma. It is mainly used to treat dizziness and insomnia, palpitations and shortness of breath, and asthenia cough and asthma.

[0014] Astragalus: The dried root of the plant Astragalus mongolica or Astragalus membranaceus, sweet, slightly warm; enters the lung and spleen meridians. It has the effects of replenishing qi and strengthening the exterior, promoting diuresis and expelling toxins, draining pus, and healing sores and promoting tissue regeneration. It is mainly used to treat physical weakness, poor appetite and loose stools, sinking of the middle qi, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, carbuncle that is difficult to heal, long-term sores that do not heal, blood deficiency and jaundice, internal heat and thirst; chronic nephritis proteinuria, diabetes.

[0015] Angelica: The root of the plant Angelica sinensis is sweet, spicy, and warm in nature. It enters the liver and heart meridians. It has the effects of nourishing blood and regulating menstruation, promoting blood circulation and relieving pain, and moistening the intestines and relieving constipation. It is mainly used to treat chlorosis due to blood deficiency, irregular menstruation, amenorrhea, dysmenorrhea, pain caused by blood deficiency, blood stasis, and cold blood, injuries from falls, rheumatic arthralgia, carbuncle sores, and constipation due to dry intestines.

[0016] Peach kernel: The seed of peach or wild peach of the Rosaceae family, bitter, sweet, flat; it enters the heart, liver, and large intestine meridians. It has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and relieving constipation. It is mainly used to treat amenorrhea, dysmenorrhea, lumps and masses, blood accumulation due to febrile diseases, rheumatism, malaria, traumatic injuries, blood stasis and swelling, and constipation due to dry blood.

[0017] Donkey hide glue: a block of glue made by depilating the skin of donkey, an equine animal. It tastes sweet and neutral. It enters the lung, liver and kidney meridians. It has the effects of nourishing blood, stopping bleeding, nourishing yin and moistening dryness. It is mainly used to treat blood deficiency syndrome, consumptive hemoptysis, hematemesis, hematuria, bloody stool, bloody dysentery, bleeding during pregnancy, metrorrhagia, yin deficiency, restlessness and insomnia, lung deficiency, cough, and spasm and convulsions caused by internal wind.

[0018] Longan pulp: The aril of the longan plant of the Sapindaceae family is sweet and warm in taste; it enters the heart and spleen meridians. It has the effects of nourishing the heart and spleen, nourishing blood and calming the mind. It is mainly used to treat palpitations, restlessness, insomnia, forgetfulness, blood deficiency, chlorosis, irregular menstruation, and metrorrhagia caused by insufficient qi and blood.

[0019] Jujube: The ripe fruit of the plant jujube of the Rhamnaceae family, sweet and warm; it enters the spleen and stomach meridians. It nourishes the spleen and replenishes qi, nourishes the heart and calms the mind. It has the effects of nourishing the spleen and stomach, replenishing qi and promoting body fluid, regulating the body's defense system, and detoxifying drugs. It is mainly used to treat poor appetite due to weak stomach, loose stools due to weak spleen, insufficient qi, blood and body fluid, disharmony between the body's defense system, palpitations, insomnia, night sweats, thrombocytopenic purpura, and impotence in women.

[0020] Yam: The tuber of Dioscorea zingiberensis, a plant of the Dioscoreaceae family, is sweet and neutral in taste; it enters the spleen, lung, and kidney meridians. It has the effects of nourishing the spleen and stomach, promoting fluid production and benefiting the lungs, and nourishing the kidneys and astringing semen. It is mainly used to treat spleen deficiency, poor appetite, chronic diarrhea, asthma and cough due to lung deficiency, spermatorrhea due to kidney deficiency, leucorrhea, frequent urination, and deficiency heat and thirst.

[0021] Polygonatum odoratum: The rhizome of Polygonatum odoratum, a plant of the Liliaceae family, is sweet and neutral in taste; it enters the lung and stomach meridians. It has the effects of nourishing yin and moistening the lungs, nourishing the stomach and producing body fluids. It is mainly used to treat dry cough, fatigue cough, dry throat and thirst due to loss of yin fluid due to fever, internal heat and thirst, yin deficiency and external infection, dizziness, and muscle and vein spasm and pain.

[0022] Lycium barbarum: The ripe fruit of Lycium barbarum or Ningxia Lycium barbarum of the Solanaceae family, sweet and flat; enters the liver and kidney meridians. It has the effect of nourishing the liver and kidneys, improving the essence and improving the eyesight. It is mainly used to treat asthenia, deficiency of essence, soreness of waist and knees, dizziness and tinnitus, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.

[0023] Poria: The dried sclerotium of the plant Poria of the Polyporaceae family is sweet, light and flat in taste; it enters the heart, lung, spleen and kidney meridians. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and calming the mind. It is mainly used to treat edema, oliguria, phlegm and fluid, dizziness and palpitations, spleen deficiency and poor appetite, loose stools and diarrhea, restlessness, palpitations and insomnia.

[0024] Rose: The first blooming flower of the rose plant of the Rosaceae family, sweet and slightly bitter, warm; enters the liver and spleen meridians. It has the effects of regulating qi and relieving depression, harmonizing blood and dispersing blood stasis. It is mainly used to treat liver and stomach qi pain, new and long-term wind arthralgia, vomiting blood and coughing, irregular menstruation, leucorrhea, dysentery, breast abscess, and swelling.

[0025] Tangerine peel: The dried mature peel of the citrus plant and its cultivated varieties of the Rutaceae family. It tastes bitter, pungent, and warm; it enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is mainly used to treat chest and abdominal distension, loss of appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0026] Among the Chinese medicine components described in the present invention, astragalus, angelica, and rehmannia root are the main drugs, which mainly play the role of replenishing qi and blood, regulating menstruation and nourishing blood; white peony root and chuanxiong are the ministerial drugs, which assist the main drugs to enhance the effect of nourishing blood and regulating menstruation; wolfberry fruit and donkey-hide gelatin are adjuvant drugs, which nourish the liver and kidney and enhance the overall efficacy; codonopsis, tuckahoe, and liquorice are the guiding drugs, which harmonize the drugs and strengthen the spleen and replenish qi. The specific ratio is determined according to clinical practice and pharmacological research to achieve the best efficacy. The Chinese medicinal materials are mixed in a specific ratio, and are processed by washing, infiltration, cutting and other processes to ensure that the effective ingredients of the medicine are fully released and easy to absorb.

[0027] The Chinese medicinal raw materials of the invention are prepared through scientific proportioning and unique processing technology, through extraction, double-effect concentration, filtration and blending processes, and the Chinese medicinal materials are processed by adopting scientific and technologically innovative multiple extraction, concentration and extraction technology.

[0028] The present invention also provides a method for preparing a Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency, comprising the following steps:

[0029] S1 Pretreatment of Chinese medicinal materials: Put the main ingredients of Chinese medicinal materials in specific weight proportions: 15-20 parts of ginseng, 15-20 parts of codonopsis, 15-20 parts of ganoderma lucidum, 15-20 parts of astragalus, 15-20 parts of angelica, 15-20 parts of peach kernel, 15-20 parts of donkey-hide gelatin, 15-20 parts of longan pulp, 8-12 parts of jujube, 7-10 parts of yam, 7-10 parts of polygonatum, 7-10 parts of wolfberry, 7-10 parts of poria, 7-10 parts of rose and 7-10 parts of tangerine peel into a medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into a vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to obtain the pre-treated Chinese medicinal materials, so that they are convenient for later extraction;

[0030] S2 Extraction of effective components of traditional Chinese medicine: weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials, and combine them to obtain the traditional Chinese medicine extract;

[0031] S3 double-effect concentration: pour the combined Chinese medicine extract into the container of the vacuum concentrator, and concentrate it under low-temperature vacuum pressure for 2-4 hours until the volume is reduced to 1 / 3 of the original volume to obtain a concentrated solution;

[0032] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, and keep the temperature at 20℃-60℃ to remove impurities and particles in the extract to obtain a clear Chinese medicine filtrate;

[0033] S5 post-processing: The filtrate of traditional Chinese medicine is subjected to subsequent processing, including preparation, sterilization and packaging.

[0034] The pre-treatment process of Chinese medicinal materials generally includes washing, moistening, cutting and other processes. The pre-treatment of Chinese medicinal materials is a key process in production and an important link in improving quality and efficiency. The surface of medicinal materials not only has debris such as mud and sand, but also a large number of molds. The purpose of washing the medicine is to remove the mud and sand and most of the molds. On the premise of washing, the washing time should be shortened as much as possible to avoid the loss of effective ingredients. Before cutting the medicinal materials, they need to be softened by soaking and other softening treatments to make them moderately soft and hard for easy cutting. The soaking should ensure that the medicine is fully penetrated, and the medicinal materials should not be damaged by water, rotten, moldy, or produce odors. The purpose of moistening the medicine is to allow the dehydrated plant cells to absorb water and create conditions for the extraction process. Working principle of vacuum medicine moistening machine: use vacuum to extract air from the gaps in the medicinal material fibers, and water quickly enters the plant cell tissue through capillaries under negative pressure conditions; among them, controlling the vacuum degree can achieve the best penetration effect of different medicinal materials, controlling the amount of water added can prevent the loss of effective ingredients, and controlling the moistening time can reduce the enzymatic hydrolysis of effective ingredients. Some glycosides have corresponding hydrolases in the cells, and some glycosides will be hydrolyzed if the time is too long. The purpose of cutting is to ensure the extraction quality of medicinal materials and facilitate further processing and preparation. According to different medicinal materials and properties, cutting methods such as cutting, pounding, planing, filing, and splitting are purchased separately, and the medicinal materials are cut into slices, segments, silk, blocks, etc. according to the process requirements, which is conducive to the extraction steps of medicinal materials.

[0035] In the process of extracting effective ingredients from traditional Chinese medicine, different medicinal materials have different dissolution rates of effective ingredients in different solvents. Ginseng, Codonopsis, Angelica, Longan Meat, Jujube, Chinese Yam, Polygonatum, Poria, and Rose have higher extraction efficiency in water; while Ganoderma Lucidum, Astragalus, Peach Kernel, Donkey-hide Gelatin, Lycium Barbarum, and Tangerine Peel have better extraction effects in ethanol solution. The water extraction method is to heat the medicinal materials with an appropriate amount of water and boil them for a certain period of time to extract the effective ingredients; the alcohol extraction method is to soak the medicinal materials in an appropriate amount of alcohol, stir them for a certain period of time, and then filter them to obtain the extract. Determine the extraction time during the extraction process. Excessive extraction will increase the impurities in the extract and make it more difficult to separate them later. If the time is too short, the extraction will be incomplete, wasting raw materials.

[0036] Preferably, the extraction of the effective ingredients of traditional Chinese medicine comprises the following steps:

[0037] S21 water extraction method: according to the ratio, weigh ginseng, codonopsis, angelica, longan pulp, jujube, yam, polygonatum, poria, and rose, put them into an extraction pot, add clean water, the material-liquid ratio is 1:5-10, soak for 1-3 hours to fully absorb water, heat to boiling, maintain boiling state for 30-60 minutes, filter the extract, separate the residue and the liquid, and collect the first clear liquid;

[0038] S22 alcohol extraction method: according to the ratio, weigh ganoderma lucidum, astragalus, peach kernel, donkey-hide gelatin, wolfberry, and tangerine peel and put them into an extraction pot, add 60-80% ethanol solution, the solid-liquid ratio is 1:4-10, soak for 2-4 hours to fully absorb the alcohol, heat to 60-80℃, maintain the temperature for 3-5 hours, filter the extract after ensuring sufficient extraction, separate the residue from the liquid, and collect the second clear liquid;

[0039] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0040] S24 combining: evenly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract.

[0041] During the extraction and decoction process, it is necessary to collect the volatile oils produced by the medicinal materials during decoction. The presence of volatile oils is of great significance during the decoction of qi and blood tonifying medicinal materials. Volatile oils, also known as essential oils, are a type of volatile oily liquid that can be distilled with water vapor. They are difficult to dissolve in water, but can evaporate with water vapor during the decoction process. Among the effective ingredients of qi and blood tonifying medicinal materials, volatile oils are an important component of the medicinal effect. They have the effects of promoting qi and blood circulation, relieving pain, and can enhance the blood tonifying effect of medicinal materials. Therefore, the appearance of volatile oils during the decoction process is proof that the medicinal effect has been boiled out. Collecting the volatile oils produced by the decoction of medicinal materials and adding them to the extract can improve the utilization rate of Chinese medicinal materials. During preparation and application, the stability and activity of volatile oils need to be considered to ensure the efficacy and safety of medicinal materials.

[0042] Furthermore, the volatile oil is collected in the extraction step S23 of the effective components of the traditional Chinese medicine, including: after the extract is boiled, the steam passes through the condenser and the cooler to reach the oil-water separator, and then passes through the oil-water interface detection device to automatically start the oil collection device to complete the collection of the volatile oil.

[0043] Condensers and coolers can effectively cool vapor into liquid, facilitating subsequent oil-water separation operations, while also helping to prevent volatile oils from changing composition or evaporating due to excessive temperature.

[0044] The oil-water interface detection device can automatically start the oil collection device. Compared with traditional manual observation and manual collection methods, automated collection can capture the separation moment of volatile oil more timely and accurately, avoiding the loss of volatile oil or incomplete collection caused by delayed or inaccurate manual operation.

[0045] The oil-water interface detection device can accurately sense the interface of oil-water separation, ensuring that only volatile oil is collected without excessive water or other impurities. This accuracy helps to improve the purity of volatile oil, thereby better retaining its medicinal ingredients, which is of great significance to the quality and efficacy of the final Chinese medicine composition.

[0046] The systematic design of the entire process from the vapor flow path after the extract boils, that is, through the condenser and cooler to the oil-water separator, and then to the oil collection device, ensures that the volatile oil is in a relatively stable environment during the entire collection process, reducing the impact of external factors on the quality of the volatile oil.

[0047] Collecting volatile oils through fixed equipment and processes is conducive to quality control of the entire production process, ensuring that each batch of volatile oils collected has relatively stable quality and composition, thereby ensuring the quality stability and consistency of the Chinese medicine composition.

[0048] The automated oil collection device and the complete collection process can improve the collection efficiency of volatile oils and reduce the collection time. In large-scale industrial production, this means that more medicinal materials can be processed in a shorter time, which improves production efficiency and reduces production costs, and is suitable for the needs of industrial production.

[0049] According to the different dissolution rates of active ingredients of different medicinal materials in different solvents, ginseng, codonopsis, angelica, longan pulp, jujube, yam, polygonatum, poria, and rose have higher extraction efficiency in water, so water extraction is used for extraction. This targeted extraction method can more effectively obtain the active ingredients in these medicinal materials and improve the extraction efficiency and quality.

[0050] Furthermore, the extraction step S21 of the effective ingredients of traditional Chinese medicine is a water extraction method, and the heating and boiling process is also accompanied by uninterrupted variable speed stirring, using segmented speed change, and the initial stage is a lower speed of 50-100 rpm in the first 15-25 minutes of heating extraction to avoid material splashing and excessive damage to the structure of the medicinal materials, while promoting the full infiltration and preliminary mixing of the materials; as the extraction process proceeds, the stirring speed is gradually accelerated to 100-200 rpm in 25-35 minutes to enhance the mass transfer effect and promote the effective ingredients to be better dissolved; in the late extraction period of 35-60 minutes, a high speed of 200-250 rpm is maintained to reduce the shearing effect on the dissolved components and maintain the stability of the system; after 60-65 minutes, it is gradually decelerated to 50-100 rpm; the speed change process is smoothly transitioned to avoid the sudden change of speed causing an impact on the system, resulting in material overflow or uneven stirring; the dissolved saponin components are used as surfactants in the water extraction process. The heating process is accompanied by continuous stirring, which is convenient for the dissolution of saponin components and enhances the extraction effect. In the water extraction step, the Chinese medicinal herbs ginseng and codonopsis contain saponin components. Ginsenoside and codonopsis saponin themselves have surface activity and can be used as natural surfactants in the water extraction process. They can not only promote the dissolution of effective ingredients, but also have a synergistic effect with other ingredients in the medicinal materials to enhance the extraction effect. Different from the traditional method that requires additional addition of chemical surfactants, the present invention innovatively uses ingredients in natural plants as surfactants, which has certain advantages in terms of safety while ensuring the extraction effect. This feature of taking safety into account while pursuing the extraction effect is an important innovation of the water extraction process, which meets the comprehensive requirements of Chinese medicine extraction for natural, safe and efficient.

[0051] The heating process of water extraction is accompanied by uninterrupted variable speed stirring, which facilitates the dissolution of saponin components and reduces the damage to the structure of the medicinal materials. The uninterrupted variable speed stirring operation prevents the agglomeration and precipitation of the water-extracted medicinal materials, further enhances the extraction effect, ensures that the active ingredients are protected, and can be more fully released from the medicinal materials.

[0052] Double-effect concentration is a process of vacuum concentrating the extract to reduce the volume of the liquid while retaining the effective ingredients. During double-effect concentration, the secondary steam generated by the primary steam concentration is concentrated in the next step, and the concentrated liquid medicine enters the primary concentration in series, that is, the steam generated by the primary concentration is used as the heat source for the secondary concentration, while saving money and energy. Double-effect concentration uses two-effect simultaneous evaporation, and the secondary steam is fully utilized, which not only saves the investment in the boiler, but also saves energy consumption. The energy consumption is reduced by 50% compared with the single-effect concentrator. In addition, the double-effect concentrator adopts external heating natural circulation and vacuum negative pressure, with fast evaporation speed and high concentration ratio. The liquid material is concentrated without foam in a fully sealed state, and the concentrated liquid medicine is pollution-free, has a strong medicinal taste, and is easy to clean. Through double-effect concentration, the concentration of the composition can be increased and its efficacy can be enhanced. The use of vacuum decompression concentration can speed up the concentration speed; when recovering the Chinese medicine extract, the vacuum degree should not be too large to reduce the loss of the effective ingredients of the medicinal materials.

[0053] Preferably, in the double-effect concentration, 0.1-1% citric acid is added to adjust the pH to weak acidity, the vacuum degree is 0.06-0.09 MPa, and the temperature is 60-70°C.

[0054] Different medicinal active ingredients have better stability at different pH values. By adjusting the pH value during the concentration process, the active ingredients can be placed in a more stable environment. The effective ingredients of the Chinese medicine raw materials of the present invention contain a variety of alkaloid components: ginseng contains ginsenoside, which plays a role in its effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, and replenishing the spleen and lungs; the alkaloid components in Astragalus and ginsenoside in ginseng have a synergistic effect, and jointly participate in the effects of replenishing qi and strengthening the exterior, diuresis and detoxification, and have a certain effect on enhancing the body's immune function and regulating metabolism; the alkaloid components in Angelica sinensis contribute to its effects of replenishing blood and regulating menstruation, promoting blood circulation and relieving pain, and participate in regulating the female endocrine system and improving symptoms such as irregular menstruation; the alkaloid components in Lycium barbarum play a role in nourishing the liver and kidneys, improving the essence and improving the eyesight, participate in regulating the body's metabolism and physiological functions, and help improve symptoms such as liver and kidney yin deficiency. These alkaloid components are more stable in an acidic environment. Therefore, when extracting and concentrating medicinal materials containing alkaloids, adding an appropriate amount of acid regulator citric acid can maintain the acidic environment of the solution and protect the stability of the alkaloids.

[0055] Filtration is an effective method to ensure the purity of the final product by filtering the concentrate to remove impurities. Excessive temperature may affect the active ingredients of the extract. Gradual filtration is to set up multiple filtration stages, first use a larger pore filter for coarse filtration, then a small pore filter for fine filtration, and then use an ultrafiltration membrane for ultrafiltration, which can effectively remove impurities and particles in the extract, obtain a clear Chinese medicine filtrate, and ensure the purity and quality of the extract.

[0056] Preferably, the filtering comprises the following steps:

[0057] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 100-500 microns, and the diameter size is 10-30 cm; adjust the flow rate and pressure, the pressure is 0.2-0.5 MPa, and the flow rate is set to 2-10 liters / minute;

[0058] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter, the pore size of the fine filter is 0.1-10 microns, and the diameter is 5-15 cm; adjust the flow rate and pressure, the pressure is controlled at 0.1-0.3 MPa, and the flow rate is set to 1-5 liters / minute to avoid damage to the membrane or filter material;

[0059] S43 ultrafiltration: introduce the finely filtered liquid into the ultrafiltration device, the pore size of the ultrafiltration membrane is 1-100 nanometers; adjust the operating pressure, the pressure is controlled at 0.02-0.5 MPa, and the flow rate is controlled at 1-3m / s;

[0060] S44 Collection: Collect the clear Chinese medicine filtrate after ultrafiltration into a clean container and prepare for preparation.

[0061] Through the graded filtration process, large amounts of Chinese medicine extracts can be processed efficiently and stably to ensure the quality and safety of the final product.

[0062] During the filtration process, select the appropriate filter pore size and control the flow rate and pressure during filtration to avoid damage to the membrane or filter material. Observe the effluent of the coarse filtration to ensure that large particles and suspended solids are effectively removed; monitor the filtration process of the fine filtration to ensure that fine particles are removed and the flow rate is stable; monitor the flow rate of the permeate and concentrate of the ultrafiltration to ensure filtration efficiency; regularly check the status of the filter, filter element and membrane, and clean or replace them as needed to ensure filtration efficiency.

[0063] The filtered liquid is subsequently processed as needed to ensure the safety of the product and the stability of the active ingredients. The filtered concentrate is mixed in proportion to make the final oral solution, which can ensure that the active ingredients of each dose are consistent.

[0064] The present invention provides a Chinese medicine composition for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency. Special ingredients are added to protect the stability of effective ingredients of Chinese medicinal materials without affecting the effects of traditional Chinese medicine formulas. At the same time, the effect of adjusting the taste can be achieved, thereby overcoming the defect that traditional Chinese medicine decoctions are bitter and difficult to swallow.

[0065] Preferably, the preparation process of step S51 in the post-treatment is: mix the ingredients licorice extract and citric acid in a mass ratio of 1-2:2-3 for 10-15 minutes, then add them to the traditional Chinese medicine filtrate and mix evenly, the mass ratio is 1-5:99-95, and the time is 30-60 minutes.

[0066] Licorice extract has a natural sweetness and can also adjust the taste of other medicinal materials. Citric acid can enhance the sour taste, increase the refreshing feeling, and also has an antiseptic effect. The selection, proportioning and addition of ingredients of the present invention can enhance the taste of the Chinese medicine composition through a small dose, overcome the bitter defect of traditional Chinese medicine decoctions that are difficult to swallow, and improve the user's drinking experience.

[0067] The prepared mixed solution is heat treated and sterilized at high temperature to ensure the safety of the product.

[0068] Furthermore, the sterilization process of step S52 in the post-processing is: segmented temperature rising sterilization.

[0069] S521 Initial heating stage: starting from room temperature, slowly increase the temperature to 50-60℃ within 15-30 minutes at a heating rate of 1-2℃ per minute; gradually increase the temperature to allow the medicinal materials and medicinal solutions to gradually adapt to the temperature increase, reducing the impact of drastic temperature changes on the effective ingredients of Chinese medicine raw materials; a temperature of 60℃ can initially kill some heat-sensitive microorganisms, laying the foundation for the subsequent sterilization process.

[0070] S522 The first constant temperature stage: the temperature is maintained at 50-60℃ for 30-60 minutes; at this temperature, some effective ingredients of traditional Chinese medicine that are more sensitive to temperature can remain stable in a relatively mild environment, while further killing some microorganisms, especially some mesophilic microorganisms.

[0071] S523 Secondary heating stage: Increase the temperature from 50-60℃ to 85-95℃ at a rate of 1.0-2.0℃ per minute within 20-30 minutes; gradually increase the temperature to continue to enhance the sterilization effect while avoiding the impact of rapid temperature changes on the active ingredients.

[0072] S524 second constant temperature stage: the temperature is maintained at 85-95℃ for 30-45 minutes; at a temperature of 85-95℃, most heat-resistant microorganisms can be effectively killed to ensure the sterility of the product; at the same time, through the initial slow heating process, the active ingredients can also maintain their activity relatively stably in this stage.

[0073] S525 Final heating stage: heating from 85-95℃ to 100-130℃ at a rate of 0.5-1℃ per minute within 20-40 minutes; reaching the final high temperature sterilization temperature, completely killing all possible microorganisms and ensuring product safety.

[0074] S526 Cooling stage: Cool within 30-60 minutes, cooling to room temperature at a rate of 1-5℃ per minute; restore the product temperature to room temperature to facilitate subsequent packaging and storage operations, while avoiding adverse effects of sudden temperature drops on product quality.

[0075] The prepared solution of the Chinese medicine composition of the present invention is packaged and can be filled into an oral liquid to achieve the effects of convenient administration, safety, portability and convenience of carrying.

[0076] Furthermore, the packaging process of step S53 in the post-processing is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0077] The present invention provides a traditional Chinese medicine composition for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency. Through reasonable raw material ratios and scientific preparation methods, the composition has a reasonable formula, significant therapeutic effect, and is easy to take. The composition can effectively replenish qi and blood and treat scanty menstruation caused by qi and blood deficiency, has good safety and effectiveness, and provides a new treatment option for female patients with irregular menstruation and a new option for women's health management.

[0078] In summary, the present invention has the following beneficial effects:

[0079] 1. The Chinese medicine composition provided by the present invention for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency is derived from the imperial prescription of Luo Shichong, an imperial physician in the Daoguang period of the Qing Dynasty: Luo's Tianjing Dihua Dan. Through the scientific ratio of carefully selected Chinese medicinal materials and the synergistic effect of multiple Chinese medicinal materials, it can quickly and effectively replenish the body's qi and blood, improve the overall health level, improve fatigue, and relieve the discomfort caused by qi and blood deficiency;

[0080] 2. The present invention adopts natural Chinese medicinal materials and a multi-extraction, concentration and extraction process with scientific and technological innovation, which avoids the side effects of chemical drugs and provides users with a safe and non-dependent conditioning solution;

[0081] 3. The Chinese medicine composition of the present invention can effectively regulate the endocrine system, improve the problems of irregular menstruation and scanty menstruation, regulate qi and blood, help balance the endocrine system, promote menstrual regularity, increase menstrual blood volume, relieve symptoms of irregular menstruation, and promote female physiological health; through the synergistic effect of the Chinese medicine compound, it can not only improve menstrual conditions, but also enhance overall health, enhance immunity, improve sleep quality and relieve anxiety; ingredients in the formula such as longan meat and angelica can help calm the nerves, relieve insomnia, dreaminess and other problems, and promote good sleep; ingredients such as astragalus and ganoderma have the effect of enhancing immune function, help improve body resistance and prevent diseases

[0082] 4. The water extraction method in the preparation process of the present invention is different from the traditional method. It adopts segmented speed change to prevent the agglomeration and precipitation of the water-extracted medicinal materials, and innovatively uses the components in natural plants as surfactants. While pursuing the extraction effect, it also takes into account the characteristics of safety, further enhancing the extraction effect, ensuring that the effective ingredients are protected, and can be more fully released from the medicinal materials, which meets the comprehensive requirements of Chinese medicine extraction for natural, safe and efficient; the sterilization process is segmented temperature sterilization, which enhances the sterilization effect while avoiding the impact of too fast temperature changes on the effective ingredients, and can avoid the adverse effects of sudden temperature drops on product quality;

[0083] 5. The preparation method of the Chinese medicine composition of the present invention is simple and convenient, and is easy to industrialize and produce, thereby ensuring stable product quality and facilitating large-scale promotion and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0084] Figure 1 It is a schematic diagram of the preparation process of a Chinese herbal extract for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency;

[0085] Figure 2 It is a schematic diagram of the volatile oil extraction process;

[0086] In the figure: 1. Water extraction tank; 2. Alcohol extraction tank; 3. Condenser; 4. Cooler; 5. Oil-water separator; 6. Oil-water interface detection device; 7. Oil collection device. DETAILED DESCRIPTION

[0087] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

[0088] Example 1

[0089] S1 Pretreatment of Chinese medicinal materials: Put the Chinese medicinal materials into the medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into the vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to facilitate the subsequent extraction;

[0090] S2 Extraction of effective ingredients of traditional Chinese medicine: Weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials at the same time, and combine them to obtain the traditional Chinese medicine extract:

[0091] S21 water extraction method: according to the ratio, 17 parts of ginseng, 17 parts of codonopsis, 17 parts of angelica, 17 parts of longan pulp, 10 parts of jujube, 8 parts of yam, 8 parts of polygonatum, 8 parts of poria, and 8 parts of rose were weighed, put into an extraction pot, and clean water was added, with a solid-liquid ratio of 1:8, soaked for 2 hours to fully absorb water, heated to boiling, maintained in a boiling state for 50 minutes, filtered the extract, separated the residue from the liquid, and collected the first clear liquid; the heating and boiling process was also accompanied by uninterrupted variable speed stirring, using segmented speed change, in the initial stage, a lower speed of 80 rpm was used in the first 20 minutes of heating extraction, and the stirring speed was gradually accelerated to 120 rpm in 30 minutes, and a high speed of 210 rpm was maintained for 40 minutes in the later stage of extraction, and the speed was gradually reduced to 80 rpm after 60 minutes;

[0092] S22 alcohol extraction method: according to the ratio, 17 parts of Ganoderma lucidum, 17 parts of Astragalus, 17 parts of peach kernel, 17 parts of donkey-hide gelatin, 8 parts of wolfberry, and 8 parts of dried tangerine peel were weighed and put into an extraction pot, and 70% ethanol solution was added, with a solid-liquid ratio of 1:6. Soak for 3 hours to fully absorb the alcohol, heat to 70°C, maintain the temperature for 4 hours, filter the extract after ensuring sufficient extraction, separate the residue from the liquid, and collect the second clear liquid;

[0093] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0094] S24 combining: uniformly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract;

[0095] S3 double-effect concentration: pour the combined Chinese medicine extract into the container of a vacuum concentrator, and concentrate it under low-temperature vacuum for 3 hours at a vacuum degree of 0.08 MPa and a temperature of 65°C until the volume is reduced to 1 / 3 of the original volume to obtain a concentrated solution;

[0096] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, keep the temperature at 40°C, remove impurities and particles in the extract, and obtain a clear Chinese medicine filtrate:

[0097] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 200 microns and the diameter is 20 cm; adjust the flow rate and pressure, the pressure is 0.4 MPa, and the flow rate is set to 8 liters / minute;

[0098] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter with a pore size of 1 micron and a diameter of 10 cm; adjust the flow rate and pressure, control the pressure at 0.2 MPa, and set the flow rate to 3 liters / minute to avoid damage to the membrane or filter material;

[0099] S43 ultrafiltration: The finely filtered liquid is introduced into the ultrafiltration device, and the pore size of the ultrafiltration membrane is 60 nanometers; the operating pressure is adjusted, the pressure is controlled at 0.1 MPa, and the flow rate is controlled at 2m / s;

[0100] S44 collection: collecting the clear Chinese medicine filtrate after ultrafiltration into a clean container for preparation;

[0101] S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: preparation, sterilization and packaging;

[0102] The preparation process of S51 is as follows: the ingredients licorice extract and citric acid are mixed at a mass ratio of 2:3 for 12 minutes, and then added to the Chinese medicine filtrate and mixed evenly at a mass ratio of 1:99 for 40 minutes;

[0103] S52 Sterilization process: high temperature sterilization, sterilization process: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 55°C at a rate of 1.5°C per minute within 20 minutes; S522 first constant temperature stage: the temperature is maintained at 55°C for 40 minutes; S523 second temperature rise stage: rise from 55°C to 90°C at a rate of 1.4°C per minute within 25 minutes; S524 second constant temperature stage: the temperature is maintained at 90°C for 35 minutes; S525 final temperature rise stage: rise from 90°C to 120°C at a rate of 1°C per minute within 30 minutes; S526 cooling stage: cool down within 40 minutes, and cool down to room temperature at a rate of 2.5°C per minute;

[0104] The S53 packaging process is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and then perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0105] Example 2

[0106] S1 Pretreatment of Chinese medicinal materials: Put the Chinese medicinal materials into the medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into the vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to facilitate the subsequent extraction;

[0107] S2 Extraction of effective ingredients of traditional Chinese medicine: Weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials at the same time, and combine them to obtain the traditional Chinese medicine extract:

[0108] S21 water extraction method: according to the ratio, 15 parts of ginseng, 15 parts of codonopsis, 15 parts of angelica, 15 parts of longan pulp, 8 parts of jujube, 7 parts of yam, 7 parts of polygonatum, 7 parts of poria, and 7 parts of rose were weighed, put into an extraction pot, and clean water was added, with a solid-liquid ratio of 1:10, soaked for 1 hour to fully absorb water, heated to boiling, maintained in a boiling state for 30 minutes, filtered the extract, separated the residue from the liquid, and collected the first clear liquid; the heating and boiling process was also accompanied by uninterrupted variable speed stirring, using segmented speed change, in the initial stage, a lower speed of 50 rpm was used for the first 15 minutes of heating extraction, and the stirring speed was gradually accelerated to 100 rpm in 25 minutes, and a high speed of 200 rpm was maintained for 35 minutes in the later stage of extraction, and the speed was gradually reduced to 50 rpm after 60 minutes;

[0109] S22 alcohol extraction method: according to the ratio, weigh 15 parts of Ganoderma lucidum, 15 parts of Astragalus, 15 parts of peach kernel, 15 parts of donkey-hide gelatin, 7 parts of wolfberry, and 7 parts of dried tangerine peel, put them into an extraction pot, add 60% ethanol solution, the solid-liquid ratio is 1:10, soak for 2 hours to fully absorb the alcohol, heat to 60°C, maintain the temperature for 3 hours, filter the extract after ensuring sufficient extraction, separate the residue and the liquid, and collect the second clear liquid;

[0110] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0111] S24 combining: uniformly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract;

[0112] S3 double-effect concentration: pour the combined Chinese medicine extract into the container of a vacuum concentrator, and concentrate it under low-temperature vacuum for 2 hours at a vacuum degree of 0.06 MPa and a temperature of 60°C until the volume is reduced to 1 / 5 of the original volume to obtain a concentrated solution;

[0113] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, keep the temperature at 20°C, remove impurities and particles in the extract, and obtain a clear Chinese medicine filtrate:

[0114] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 100 microns and the diameter is 10 cm; adjust the flow rate and pressure, the pressure is 0.2 MPa, and the flow rate is set to 2 liters / minute;

[0115] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter with a pore size of 0.1 micron and a diameter of 5 cm; adjust the flow rate and pressure, control the pressure at 0.1 MPa, and set the flow rate at 1 liter / minute to avoid damage to the membrane or filter material;

[0116] S43 ultrafiltration: The finely filtered liquid is introduced into the ultrafiltration device, and the pore size of the ultrafiltration membrane is 40 nanometers; the operating pressure is adjusted, the pressure is controlled at 0.05 MPa, and the flow rate is controlled at 1m / s;

[0117] S44 collection: collecting the clear Chinese medicine filtrate after ultrafiltration into a clean container for preparation;

[0118] S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: preparation, sterilization and packaging;

[0119] The preparation process of S51 is as follows: the ingredients licorice extract and citric acid are mixed at a mass ratio of 1:3 for 10 minutes, and then added to the Chinese medicine filtrate and mixed evenly at a mass ratio of 1:99 for 30 minutes;

[0120] S52 Sterilization process: high temperature sterilization, sterilization process: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 50°C at a rate of 1.5°C per minute within 15 minutes; S522 first constant temperature stage: the temperature is maintained at 50°C for 30 minutes; S523 secondary temperature rise stage: rise from 50°C to 85°C at a rate of 1.75°C per minute within 20 minutes; S524 second constant temperature stage: the temperature is maintained at 85°C for 30 minutes; S525 final temperature rise stage: rise from 85°C to 105°C at a rate of 1.0°C per minute within 20 minutes; S526 cooling stage: cool within 40 minutes, and cool to room temperature at a rate of 2.0°C per minute;

[0121] The S53 packaging process is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and then perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0122] Example 3

[0123] S1 Pretreatment of Chinese medicinal materials: Put the Chinese medicinal materials into the medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into the vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to facilitate the subsequent extraction;

[0124] S2 Extraction of effective ingredients of traditional Chinese medicine: Weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials at the same time, and combine them to obtain the traditional Chinese medicine extract:

[0125] S21 water extraction method: according to the ratio, 20 parts of ginseng, 20 parts of codonopsis, 20 parts of angelica, 20 parts of longan pulp, 12 parts of jujube, 10 parts of yam, 10 parts of polygonatum, 10 parts of poria, and 10 parts of rose were weighed, put into an extraction pot, and clean water was added, with a solid-liquid ratio of 1:8, soaked for 2 hours to fully absorb water, heated to boiling, maintained in a boiling state for 50 minutes, filtered the extract, separated the residue from the liquid, and collected the first clear liquid; the heating and boiling process was also accompanied by uninterrupted variable speed stirring, using segmented speed change, in the initial stage, a lower speed of 80 rpm was used in the first 20 minutes of heating extraction, and the stirring speed was gradually accelerated to 120 rpm in 30 minutes, and a high speed of 210 rpm was maintained for 40 minutes in the later stage of extraction, and the speed was gradually reduced to 80 rpm after 60 minutes;

[0126] S22 alcohol extraction method: according to the ratio, weigh 20 parts of Ganoderma lucidum, 20 parts of Astragalus, 20 parts of peach kernel, 20 parts of donkey-hide gelatin, 10 parts of wolfberry, and 10 parts of dried tangerine peel, put them into an extraction pot, add 70% ethanol solution, the solid-liquid ratio is 1:6, soak for 3 hours to fully absorb the alcohol, heat to 70°C, maintain the temperature for 4 hours, filter the extract after ensuring sufficient extraction, separate the residue and the liquid, and collect the second clear liquid;

[0127] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0128] S24 combining: uniformly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract;

[0129] S3 double-effect concentration: Pour the combined Chinese medicine extract into the container of a vacuum concentrator and concentrate it under low-temperature vacuum for 3 hours at a vacuum degree of 0.08 MPa and a temperature of 65°C, until the volume is reduced to 1 / 3 of the original volume to obtain a concentrated solution.

[0130] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, keep the temperature at 40°C, remove impurities and particles in the extract, and obtain a clear Chinese medicine filtrate:

[0131] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 200 microns and the diameter is 20 cm; adjust the flow rate and pressure, the pressure is 0.4 MPa, and the flow rate is set to 8 liters / minute;

[0132] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter with a pore size of 1 micron and a diameter of 10 cm; adjust the flow rate and pressure, control the pressure at 0.2 MPa, and set the flow rate to 3 liters / minute to avoid damage to the membrane or filter material;

[0133] S43 ultrafiltration: The finely filtered liquid is introduced into the ultrafiltration device, and the pore size of the ultrafiltration membrane is 60 nanometers; the operating pressure is adjusted, the pressure is controlled at 0.1 MPa, and the flow rate is controlled at 2m / s;

[0134] S44 collection: collecting the clear Chinese medicine filtrate after ultrafiltration into a clean container for preparation;

[0135] S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: preparation, sterilization and packaging;

[0136] The preparation process of S51 is as follows: the ingredients licorice extract and citric acid are mixed at a mass ratio of 2:3 for 12 minutes, and then added to the Chinese medicine filtrate and mixed evenly at a mass ratio of 1:99 for 40 minutes;

[0137] S52 Sterilization process: high temperature sterilization, sterilization process: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 55°C at a rate of 1.5°C per minute within 20 minutes; S522 first constant temperature stage: the temperature is maintained at 55°C for 40 minutes; S523 second temperature rise stage: rise from 55°C to 90°C at a rate of 1.4°C per minute within 25 minutes; S524 second constant temperature stage: the temperature is maintained at 90°C for 35 minutes; S525 final temperature rise stage: rise from 90°C to 120°C at a rate of 1°C per minute within 30 minutes; S526 cooling stage: cool down within 40 minutes, and cool down to room temperature at a rate of 2.5°C per minute;

[0138] The S53 packaging process is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and then perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0139] Example 4

[0140] S1 Pretreatment of Chinese medicinal materials: Put the Chinese medicinal materials into the medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into the vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to facilitate the subsequent extraction;

[0141] S2 Extraction of effective ingredients of traditional Chinese medicine: Weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials at the same time, and combine them to obtain the traditional Chinese medicine extract:

[0142] S21 water extraction method: according to the ratio, 15 parts of ginseng, 15 parts of codonopsis, 15 parts of angelica, 15 parts of longan pulp, 8 parts of jujube, 7 parts of yam, 7 parts of polygonatum, 7 parts of poria, and 7 parts of rose were weighed, put into an extraction pot, and clean water was added, with a solid-liquid ratio of 1:8, soaked for 2 hours to fully absorb water, heated to boiling, maintained in a boiling state for 50 minutes, filtered the extract, separated the residue from the liquid, and collected the first clear liquid; the heating and boiling process was also accompanied by uninterrupted variable speed stirring, using segmented speed change, in the initial stage, a lower speed of 80 rpm was used in the first 20 minutes of heating extraction, and the stirring speed was gradually accelerated to 120 rpm in 30 minutes, and a high speed of 210 rpm was maintained for 40 minutes in the later stage of extraction, and the speed was gradually reduced to 80 rpm after 60 minutes;

[0143] S22 alcohol extraction method: according to the ratio, weigh 15 parts of Ganoderma lucidum, 15 parts of Astragalus, 15 parts of peach kernel, 15 parts of donkey-hide gelatin, 7 parts of wolfberry, and 7 parts of dried tangerine peel, put them into an extraction pot, add 70% ethanol solution, the solid-liquid ratio is 1:6, soak for 3 hours to fully absorb the alcohol, heat to 70°C, maintain the temperature for 4 hours, filter the extract after ensuring sufficient extraction, separate the residue and the liquid, and collect the second clear liquid;

[0144] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0145] S24 combining: uniformly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract;

[0146] S3 double-effect concentration: pour the combined Chinese medicine extract into the container of a vacuum concentrator, and concentrate it under low-temperature vacuum for 3 hours at a vacuum degree of 0.08 MPa and a temperature of 65°C until the volume is reduced to 1 / 3 of the original volume to obtain a concentrated solution;

[0147] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, keep the temperature at 40°C, remove impurities and particles in the extract, and obtain a clear Chinese medicine filtrate:

[0148] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 200 microns and the diameter is 20 cm; adjust the flow rate and pressure, the pressure is 0.4 MPa, and the flow rate is set to 8 liters / minute;

[0149] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter with a pore size of 1 micron and a diameter of 10 cm; adjust the flow rate and pressure, control the pressure at 0.2 MPa, and set the flow rate to 3 liters / minute to avoid damage to the membrane or filter material;

[0150] S43 ultrafiltration: The finely filtered liquid is introduced into the ultrafiltration device, and the pore size of the ultrafiltration membrane is 60 nanometers; the operating pressure is adjusted, the pressure is controlled at 0.1 MPa, and the flow rate is controlled at 2m / s;

[0151] S44 collection: collecting the clear Chinese medicine filtrate after ultrafiltration into a clean container for preparation;

[0152] S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: preparation, sterilization and packaging;

[0153] The preparation process of S51 is as follows: the ingredients licorice extract and citric acid are mixed at a mass ratio of 2:3 for 12 minutes, and then added to the Chinese medicine filtrate and mixed evenly at a mass ratio of 1:99 for 40 minutes;

[0154] S52 Sterilization process: high temperature sterilization, sterilization process: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 55°C at a rate of 1.5°C per minute within 20 minutes; S522 first constant temperature stage: the temperature is maintained at 55°C for 40 minutes; S523 second temperature rise stage: rise from 55°C to 90°C at a rate of 1.4°C per minute within 25 minutes; S524 second constant temperature stage: the temperature is maintained at 90°C for 35 minutes; S525 final temperature rise stage: rise from 90°C to 120°C at a rate of 1°C per minute within 30 minutes; S526 cooling stage: cool down within 40 minutes, and cool down to room temperature at a rate of 2.5°C per minute;

[0155] The S53 packaging process is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and then perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0156] Example 5

[0157] S1 Pretreatment of Chinese medicinal materials: Put the Chinese medicinal materials into the medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into the vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to facilitate the subsequent extraction;

[0158] S2 Extraction of effective ingredients of traditional Chinese medicine: Weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials at the same time, and combine them to obtain the traditional Chinese medicine extract:

[0159] S21 water extraction method: according to the ratio, 20 parts of ginseng, 20 parts of codonopsis, 20 parts of angelica, 20 parts of longan pulp, 12 parts of jujube, 10 parts of yam, 10 parts of polygonatum, 10 parts of poria, and 10 parts of rose were weighed, put into an extraction pot, and clean water was added, with a solid-liquid ratio of 1:5, soaked for 3 hours to fully absorb water, heated to boiling, maintained in a boiling state for 60 minutes, filtered the extract, separated the residue from the liquid, and collected the first clear liquid; the heating and boiling process was also accompanied by uninterrupted variable speed stirring, using segmented speed change, in the initial stage, a lower speed of 100 rpm was used in the first 25 minutes of heating extraction, and the stirring speed was gradually accelerated to 200 rpm in 35 minutes, and a high speed of 250 rpm was maintained for 60 minutes in the later stage of extraction, and the speed was gradually reduced to 100 rpm after 65 minutes;

[0160] S22 alcohol extraction method: according to the ratio, weigh 20 parts of Ganoderma lucidum, 20 parts of Astragalus, 20 parts of peach kernel, 20 parts of donkey-hide gelatin, 10 parts of wolfberry, and 10 parts of dried tangerine peel, put them into an extraction pot, add 80% ethanol solution, the solid-liquid ratio is 1:4, soak for 4 hours to fully absorb the alcohol, heat to 80°C, maintain the temperature for 5 hours, filter the extract after ensuring sufficient extraction, separate the residue and the liquid, and collect the second clear liquid;

[0161] S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials;

[0162] S24 combining: uniformly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract;

[0163] S3 double-effect concentration: Pour the combined Chinese medicine extract into the container of a vacuum concentrator and concentrate it under low-temperature vacuum for 4 hours at a vacuum degree of 0.09 MPa and a temperature of 70°C, until the volume is reduced to 1 / 2 of the original volume to obtain a concentrated solution.

[0164] S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, keep the temperature at 60°C, remove impurities and particles in the extract, and obtain a clear Chinese medicine filtrate:

[0165] S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 500 microns and the diameter is 30 cm; adjust the flow rate and pressure, the pressure is 0.5 MPa, and the flow rate is set to 10 liters / minute;

[0166] S42 fine filtration: transfer the liquid after coarse filtration to the fine filter with a pore size of 10 microns and a diameter of 15 cm; adjust the flow rate and pressure, control the pressure at 0.3 MPa, and set the flow rate to 5 L / min to avoid damage to the membrane or filter material;

[0167] S43 ultrafiltration: introduce the finely filtered liquid into the ultrafiltration device, the pore size of the ultrafiltration membrane is 100 nanometers; adjust the operating pressure, the pressure is controlled at 0.5 MPa, and the flow rate is controlled at 3m / s;

[0168] S44 collection: collecting the clear Chinese medicine filtrate after ultrafiltration into a clean container for preparation;

[0169] S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: preparation, sterilization and packaging;

[0170] The preparation process of S51 is as follows: the ingredients liquorice extract and citric acid are mixed at a mass ratio of 1:1 for 15 minutes, and then added to the Chinese medicine filtrate and mixed evenly at a mass ratio of 5:95 for 60 minutes;

[0171] S52 Sterilization process: high temperature sterilization, sterilization process: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 60°C at a rate of 2.0°C per minute within 30 minutes; S522 first constant temperature stage: the temperature is maintained at 60°C for 60 minutes; S523 second temperature rise stage: rise from 60°C to 95°C at a rate of 1.2°C per minute within 30 minutes; S524 second constant temperature stage: the temperature is maintained at 95°C for 45 minutes; S525 final temperature rise stage: rise from 95°C to 130°C at a rate of 0.9°C per minute within 40 minutes; S526 cooling stage: cool within 60 minutes, and cool to room temperature at a rate of 1.75°C per minute;

[0172] The S53 packaging process is: use a filling machine to fill the cooled and sterilized mixed solution into bottles, and then perform outer packaging to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

[0173] Comparative Example 1

[0174] A similar product on the market is Bazhen Paste, whose main raw materials are honey, water, jujube, Poria cocos, wolfberry, longan, double-petal red rose, ginseng (artificially cultivated for five years or less), and yellow gelatin; the manufacturer is Bozhou Qixintang Biotechnology Co., Ltd.

[0175] 1. Experimental Methods

[0176] 300 subjects with scanty menstruation who voluntarily accepted treatment were screened. The main symptoms were scanty menstruation, dark menstrual blood, sallow complexion, poor complexion, fatigue, scanty menstruation, insomnia and other symptoms. Before receiving treatment, the symptoms of each subject were recorded and the number of people with each symptom was counted.

[0177] The subjects were divided into 6 groups, each with 50 people, and the oral liquids prepared in Examples 1-5 and the commercially available similar product Bazhen Gao of Comparative Example 1 were taken orally respectively. The Example group took 10 ml each time, 3 times a day, and the Comparative Example group took 10 grams each time 3 times a day. After taking the oral liquids for 2 consecutive months, the conditioning therapy effects of the patients were evaluated, and the effect evaluation criteria are shown in Table 1.

[0178] Table 1 Evaluation criteria for treatment efficacy

[0179] Effect Evaluation Criteria get well Symptoms, signs and symptoms disappear or almost disappear Significant effect Symptoms and signs improved significantly Improvement Symptoms and signs have improved invalid Symptoms and signs have not improved significantly, or have worsened

[0180] 2. Experimental results

[0181] (1) The improvement rate of scanty menstruation after consumption by the subjects in the Example group and the Comparative Example group was evaluated. The conditioning effects of the oral liquid dosage form of the Chinese medicine composition prepared in Examples 1-5 and the commercially available similar product Bazhen Gao in Comparative Example 1 are shown in Table 2.

[0182] Table 2 The therapeutic effect of the drug on subjects with scanty menstruation caused by deficiency of Qi and blood (unit: case)

[0183] Group Sample size n get well Significant effect Improvement invalid Total Effectiveness Example 1 50 10 15 13 12 76.00% Example 2 50 8 14 13 15 70.00% Example 3 50 9 12 15 14 72.00% Example 4 50 9 13 14 14 72.00% Example 5 50 9 17 11 13 74.00% Comparative Example 1 50 6 11 13 20 50.00%

[0184] Result analysis: The improvement rates of Examples 1-5, i.e., the total effective rates, are all ≥70%, indicating that the Chinese medicine compositions prepared in Examples 1-5 have a good effect in treating oligomenorrhea and are worthy of vigorous promotion and application. In addition, the effective ingredients in the formula of the Chinese medicine compositions prepared in the examples of the present invention are all made of raw materials that are both medicinal and edible. During the conditioning process, the trial users did not have any adverse feedback, indicating that the Chinese medicine compositions obtained in the present invention are safe and have no side effects.

[0185] (2) The therapeutic effects of the oral liquid dosage form of the Chinese medicine compositions prepared in Examples 1-5 and the commercially available similar product of Comparative Example 1, Bazhen Gao, on each symptom were further verified. The results are shown in Table 3.

[0186] Table 3 The therapeutic effects of different symptoms on subjects with insufficient Qi and blood (effectiveness, %)

[0187] Fatigue Pale complexion and poor complexion scanty menstruation Fear of cold Insomnia and dreaminess Dizziness and tinnitus Example 1 77.27 77.91 76.02 71.60 67.09 63.16 Example 2 77.20 77.65 76.00 70.65 65.66 62.58 Example 3 76.69 77.85 75.98 70.66 66.25 62.60 Example 4 77.16 77.35 75.99 71.03 66.85 63.02 Example 5 77.22 77.89 75.96 71.28 66.31 62.48 Comparative Example 1 53.51 51.65 52.35 50.36 51.53 50.07

[0188] Result analysis: From the trial results, it can be seen that the Chinese medicine composition of the present invention has an improvement rate of more than 70% for the indexes of sallow complexion, poor complexion, fatigue, scanty menstruation, and chills, and an improvement rate of more than 60% for the indexes of dizziness, tinnitus, insomnia, and dreaminess. From the experimental results, it can be seen that the total effective rate of the embodiment group for scanty menstruation is 76%, and the total effective rate of the embodiment group is better than that of the comparative example group. After statistical processing, P<0.05, there is a significant difference.

[0189] (3) Furthermore, the oral liquid Chinese medicine compositions prepared in Examples 1-5 and the commercially available similar product Bazhen Gao in Comparative Example 1 were evaluated for taste. In the evaluation process, 100 people with statistical significance were selected to taste blind samples of the same quality and evaluate and score the smell and taste. The score was based on a 10-point system, with 6 points or more being qualified, 7-8 points being acceptable, and 8 points or more being excellent. The comparative results of the taste evaluation of the oral liquid Chinese medicine compositions prepared in different Examples and the commercially available similar product Bazhen Gao in Comparative Example are shown in Table 4.

[0190] Table 4 Comparison of taste evaluation of oral liquid Chinese medicine composition prepared in Example and similar commercial product Bazhen Gao in comparative example

[0191] Group odor taste Example 1 9.5 9.6 Example 2 9.0 9.3 Example 3 9.1 9.5 Example 4 9.2 9.4 Example 5 9.3 9.3 Comparative Example 1 8.0 7.2

[0192] Result analysis: From the evaluation results, it can be seen that the smell and taste scores of the Chinese medicine composition of the present invention are much greater than those of the formula of the commercially available similar product Bazhen Paste in the control example, indicating that the Chinese medicine composition of the present invention has a higher taste evaluation and has advantages in both smell and taste.

[0193] In summary, the present invention provides a Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency. Through reasonable raw material ratio and scientific preparation method, its prescription is reasonable, effective, convenient to take, can effectively replenish qi and blood and treat oligomenorrhea caused by qi and blood deficiency, has good safety and effectiveness, provides a new treatment option for female patients with menstrual disorders, and provides a new option for women's health management. After clinical trials, the Chinese medicine composition of the present invention shows significant efficacy in replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency, and has no obvious side effects. After taking for a period of time, most patients have significantly increased menstrual volume, menstrual cycle returns to normal, and symptoms such as fatigue and pale complexion are also significantly improved. At the same time, the Chinese medicine composition of the present invention has advantages in the evaluation of the taste of smell and taste. By adding special ingredients, the stability of the effective ingredients of Chinese medicinal materials is protected without affecting the effect of the traditional Chinese medicine formula, and the effect of adjusting the taste can be achieved at the same time, overcoming the defect of the bitter and difficult entrance of traditional Chinese medicine decoctions. Therefore, the traditional Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency prepared by the present invention is safe, has few side effects, is highly effective, convenient and has a good taste.

Claims

1. A Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency, characterized in that: The invention comprises the following main ingredients and auxiliary ingredients of Chinese medicine in specific weight proportions: Main Chinese medicinal materials in specific weight proportions: 15-20 parts of ginseng, 15-20 parts of codonopsis, 15-20 parts of ganoderma lucidum, 15-20 parts of astragalus, 15-20 parts of angelica, 15-20 parts of peach kernel, 15-20 parts of donkey-hide gelatin, 15-20 parts of longan pulp, 8-12 parts of jujube, 7-10 parts of yam, 7-10 parts of polygonatum, 7-10 parts of wolfberry, 7-10 parts of poria, 7-10 parts of rose and 7-10 parts of tangerine peel; Ingredients: Licorice extract and citric acid are prepared in a mass ratio of 1-2:2-3. After mixing, the mass ratio with the Chinese medicine raw material is 1-5:99-95.

2. A method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 1, characterized in that: The following steps are involved: S1 Pretreatment of Chinese medicinal materials: Put the main ingredients of Chinese medicinal materials in specific weight proportions: 15-20 parts of ginseng, 15-20 parts of codonopsis, 15-20 parts of ganoderma lucidum, 15-20 parts of astragalus, 15-20 parts of angelica, 15-20 parts of peach kernel, 15-20 parts of donkey-hide gelatin, 15-20 parts of longan pulp, 8-12 parts of jujube, 7-10 parts of yam, 7-10 parts of polygonatum, 7-10 parts of wolfberry, 7-10 parts of poria, 7-10 parts of rose and 7-10 parts of tangerine peel into a medicine washing machine to wash away the surface mud and most of the mold; put the washed medicinal materials into a vacuum medicine moistening machine, and control the amount of water and time for soaking the medicinal materials according to the size, thickness, softness and hardness of the medicinal materials; cut the soaked medicinal materials to obtain the pre-treated Chinese medicinal materials, so that they are convenient for later extraction; S2 Extraction of effective components of traditional Chinese medicine: weigh the pre-treated traditional Chinese medicine according to the proportion, extract them by water extraction and alcohol extraction respectively, collect the volatile oil produced by the decoction of the medicinal materials, and combine them to obtain the traditional Chinese medicine extract; S3 double-effect concentration: pour the combined Chinese medicine extract into the container of a vacuum concentrator, and concentrate under low-temperature vacuum for 2-4 hours until the volume is reduced to 1 / 5-1 / 2 of the original volume to obtain a concentrated solution; S4 Filtration: Pour the double-effect concentrated extract into the filter for three-layer graded filtration, and keep the temperature at 20℃-60℃ to remove impurities and particles in the extract to obtain a clear Chinese medicine filtrate; S5 post-processing: the filtrate of traditional Chinese medicine is subjected to subsequent processing, including: S51 preparation, S52 sterilization and S53 packaging.

3. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: The extraction of the effective ingredients of the traditional Chinese medicine comprises the following steps: S21 water extraction method: according to the ratio, weigh ginseng, codonopsis, angelica, longan pulp, jujube, yam, polygonatum, poria, and rose, put them into an extraction pot, add clean water, the material-liquid ratio is 1:5-10, soak for 1-3 hours to fully absorb water, heat to boiling, maintain boiling state for 30-60 minutes, filter the extract, separate the residue and the liquid, and collect the first clear liquid; S22 alcohol extraction method: according to the ratio, weigh ganoderma lucidum, astragalus, peach kernel, donkey-hide gelatin, wolfberry, and tangerine peel and put them into an extraction pot, add 60-80% ethanol solution, the solid-liquid ratio is 1:4-10, soak for 2-4 hours to fully absorb the alcohol, heat to 60-80℃, maintain the temperature for 3-5 hours, filter the extract after ensuring sufficient extraction, separate the residue from the liquid, and collect the second clear liquid; S23 collecting volatile oil: during the extraction process, collecting volatile oil produced during the decoction of the medicinal materials; S24 combining: evenly mixing the first clear liquid, the second clear liquid and the volatile oil, and combining them to obtain a Chinese medicine extract.

4. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2 or 3, characterized in that: The step S23 of collecting volatile oil in extracting effective components of traditional Chinese medicine comprises: after the extract is boiled, the steam passes through a condenser and a cooler to reach an oil-water separator, and then passes through an oil-water interface detection device to automatically start an oil collecting device to complete the collection of volatile oil.

5. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 3, characterized in that: The extraction step S21 of the effective ingredients of traditional Chinese medicine is a water extraction method. The heating and boiling process is also accompanied by uninterrupted variable speed stirring, and a segmented speed change is adopted. In the initial stage, a lower speed of 50-100 rpm is adopted in the first 15-25 minutes of heating extraction, and the stirring speed is gradually accelerated to 100-200 rpm in 25-35 minutes. In the later stage of extraction, 200-250 rpm is maintained at a high speed of 35-60 minutes, and gradually slowed down to 50-100 rpm after 60-65 minutes; the dissolved saponin component is used as a surfactant in the water extraction process.

6. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: In the step S3 double-effect concentration, 0.1-1.0% citric acid is added to adjust the pH to be weakly acidic, the vacuum degree is 0.06-0.09 MPa, and the temperature is 60-70°C.

7. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: The filtering comprises the following steps: S41 coarse filtration: Pour the double-effect concentrate into the feed port of the coarse filter, the pore size of the coarse filter is 100-500 microns, and the diameter size is 10-30 cm; adjust the flow rate and pressure, the pressure is 0.2-0.5 MPa, and the flow rate is set to 2-10 liters / minute; S42 fine filtration: transfer the liquid after coarse filtration to the fine filter, the pore size of the fine filter is 0.1-10 microns, and the diameter is 5-15 cm; adjust the flow rate and pressure, the pressure is controlled at 0.1-0.3 MPa, and the flow rate is set to 1-5 liters / minute to avoid damage to the membrane or filter material; S43 ultrafiltration: introduce the finely filtered liquid into the ultrafiltration device, the pore size of the ultrafiltration membrane is 1-100 nanometers; adjust the operating pressure, the pressure is controlled at 0.02-0.5 MPa, and the flow rate is controlled at 1-3m / s; S44 Collection: Collect the clear Chinese medicine filtrate after ultrafiltration into a clean container and prepare for preparation.

8. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: The preparation process of step S51 in the post-treatment is: mix the ingredients licorice extract and citric acid in a mass ratio of 1-2:2-3 for 10-15 minutes, then add them to the traditional Chinese medicine filtrate and mix them evenly, the mass ratio is 1-5:99-95, and the time is 30-60 minutes.

9. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: The sterilization process of step S52 in the post-treatment is: segmented temperature rise sterilization, S521 initial temperature rise stage: starting from room temperature, slowly rise to 50-60°C at a temperature rise rate of 1-2°C per minute within 15-30 minutes; S522 first constant temperature stage: the temperature is maintained at 50-60°C for 30-60 minutes; S523 secondary temperature rise stage: within 20-30 minutes, the temperature is increased from 50-60°C to 85-95°C at a rate of 1.0-2.0°C per minute; S524 second constant temperature stage: the temperature is maintained at 85-95°C for 30-45 minutes; S525 final temperature rise stage: within 20-40 minutes, the temperature is increased from 85-95°C to 100-130°C at a rate of 0.5-1°C per minute; S526 cooling stage: cooling within 30-60 minutes, cooling to room temperature at a rate of 1-5°C per minute.

10. The method for preparing the Chinese medicine composition for replenishing qi and blood and treating oligomenorrhea caused by qi and blood deficiency according to claim 2, characterized in that: The packaging process of step S53 in the post-processing is: using a filling machine to fill the cooled and sterilized mixed solution into bottles, and then packaging them to obtain an oral liquid for replenishing qi and blood and treating scanty menstruation caused by qi and blood deficiency.

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