Portable skin storage, transportation and rewarming system for treating and curing burns in batches

Abstract

The invention discloses a portable skin storage and transportation rewarming system for treating and curing burns in batches. The system comprises a liquid nitrogen cryopreservation area, a rewarming area and an intelligent control internet-of-things area. According to the portable skin storage and transportation rewarming system for treating and curing the burns in batches, limiting teeth can be separated from corresponding gears by lifting pull rods upwards, then protection rods can be pulled until racks move into connecting boxes, after the two protection rods are pulled up, then the connecting boxes can be lifted up by means of the protection rods, and therefore the burns can be cured conveniently. After the connecting box and the packaging bag are placed in the constant-temperature water bath box, the pull rod can be pulled to rotate the protection rod to the initial position, and in the process, the distance between the position where the connecting box and the packaging bag are separated from the inner box is close to the position where the connecting box and the packaging bag are placed in the constant-temperature water bath box. Moreover, regional operation is not needed in the transfer process, so that the transfer time is shortened, the condition that the activity of the xenogeneic skin tissue sample in the packaging bag is damaged due to long transfer time is reduced, and the practicability of the device is improved.

Description

Technical Field

[0001] The invention relates to the technical field of heterologous skin transportation, and in particular to a portable skin storage, transportation and rewarming system for batch burn treatment. Background Art

[0002] Burns are injuries to human skin and tissues caused by high temperatures or high energy sources such as burning substances, electric current, radiation or chemicals. With the development of modern warfare, especially high-tech warfare, large-area burns have become one of the common injuries. If there is not enough skin graft source, patients with large-area burns will find it difficult to receive timely and effective treatment, which will lead to an increase in the death and disability rate of burn victims.

[0003] At present, the lack of allogeneic skin sources will lead to "no skin available" for the treatment of large-scale burns in wartime, which seriously limits the treatment of such burn victims. With the development of gene editing technology, it is possible to reduce the immunogenicity of pig skin and alleviate transplant rejection through gene editing. Compared with the pursuit of lifelong immune tolerance in xenogeneic solid organ transplantation, xenogeneic skin transplantation is used in the treatment of large-scale burns in batches. Its purpose is to cover and protect the burn wound in a short time and provide a sufficient time window for autologous skin transplantation. Pig skin that has undergone multi-gene editing has less immune rejection and a longer survival time. Its clinical application is more feasible and less ethically controversial. Skin grafts can be stored for many years or even decades under liquid nitrogen (-196℃). Low temperature environment can effectively inhibit cell metabolic activity and reduce cell damage, thereby maintaining the biological activity of skin grafts. This is particularly important for xenogeneic skin transplantation because it allows skin grafts obtained at different time points to be stored for a long time until they are taken out and used when needed.

[0004] The time between taking the skin graft out of the liquid nitrogen storage device and putting it into the thawing device is relatively long in the traditional device, and the long interval will seriously damage the activity of the xenogeneic skin tissue sample, which will lead to poor healing after the skin graft is transplanted. Therefore, it is extremely important to accurately match the period of surgical transplantation and achieve instant rewarming of the xenogeneic skin graft frozen in liquid nitrogen. To this end, this application proposes a portable skin storage and rewarming system for batch burn treatment, which provides a new technical solution to solve the above-mentioned technical problems. Summary of the invention

[0005] Based on this, it is necessary to provide a portable skin storage and rewarming system for batch burn treatment in response to the above technical problems. The limiting tooth can be separated from the corresponding gear by pulling the pull rod upward, and then the protective rod can be pulled to move the rack into the connecting box. After both protective rods are pulled up, the connecting box can be lifted up by relying on the protective rods, and then it can be quickly inserted into the appropriate position in the constant temperature water bath. After placing the connecting box and the packaging bag in the constant temperature water bath, the pull rod can be pulled to rotate the protective rod to the initial position, and then the connecting box and the packaging bag can be moved out of the inner box and then placed in the constant temperature water bath. The distance between the position where the connection box and the packaging bag leave the inner box and the position where they are placed in the constant temperature water bath is relatively close, and no regional operation is required during the transfer process, which shortens the transfer time, thereby reducing the possibility that the activity of the xenogeneic skin tissue sample in the packaging bag is damaged due to the long transfer time, thereby improving the practicality of the device, and during the transfer process, the connection box is driven to move by two protective rods, thereby avoiding frostbite on the operator's hands due to the low temperature of liquid nitrogen, thereby improving the safety of the device, and during the storage and transportation of the device, the protective rod protects the pressing block, reduces the possibility that the pressing block is accidentally pressed, and improves the stability of the device.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] A portable skin storage, transportation and rewarming system for batch burn treatment, which is used for gene-edited xenogeneic skin transplantation.

[0008] The portable skin storage, transportation and rewarming system for batch burn treatment specifically includes:

[0009] Liquid nitrogen freezing area, thawing area and intelligent control IoT area;

[0010] The liquid nitrogen freezing area is used to freeze and preserve the skin slices, and the liquid nitrogen freezing area includes a liquid nitrogen freezing box and a temperature insulation board, the outer wall of the liquid nitrogen freezing box is fixedly connected to the temperature insulation board, the inner wall of the liquid nitrogen freezing box is fixedly installed with a controller, the inner wall of the liquid nitrogen freezing box is fixedly connected to an inner box, a plurality of storage mechanisms are arranged in the inner box, and a pressure relief valve is fixedly installed on the inner wall of the inner box;

[0011] The rewarming zone is used to thaw and rewarm the frozen skin piece, and the rewarming zone includes a constant temperature water bath, and the side of the insulation board away from the liquid nitrogen freezing box is fixedly connected to the constant temperature water bath, and a plurality of storage mechanisms are arranged in the constant temperature water bath, and a stirring mechanism is arranged on the constant temperature water bath;

[0012] The intelligent control IoT area includes a storage entry and exit recording module, a real-time monitoring module, a location tracking module, an operation recording module, and an information function recording module;

[0013] The entry and exit recording module records the time when the skin graft enters and leaves the skin tissue bank respectively; the real-time monitoring module monitors the water temperature in the constant temperature water bath, the water temperature is 4-37°C; the position tracking module tracks and monitors the storage and transportation position of the skin graft in real time; the operation recording module records the time when the skin graft is transferred from the liquid nitrogen freezing box to the constant temperature water bath, and records the time period from the start of rewarming to the start of surgical transplantation, and records the time when the instantaneous rewarming temperature of the skin graft reaches the target rewarming temperature; the information function module records the number of the skin graft, the time of ex vivo removal and the storage conditions.

[0014] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the storage mechanism includes a hole box, a fluororubber ring, a connection box, a monitoring component, a scraping component, a protection and fixing component, a limiting component, a pressing component, an extrusion component, and a detection component. The inner wall of the hole box is tightly attached to the fluororubber ring, and the inner wall of the fluororubber ring is fixedly connected to the connection box.

[0015] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the monitoring component includes a first contact sensor, the first contact sensor is fixedly installed on the top of the hole box, and the second contact sensor compatible with the first contact sensor is fixedly installed on the top of the connecting box, and the first contact sensor and the second contact sensor are both electrically connected to the controller.

[0016] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the scraping assembly includes a fixing rod, and the bottom of the connecting box and near the left and right edges are respectively fixedly connected with fixing rods, the front and rear inner walls of the hole box are respectively rotatably connected with rotating shafts, the outer walls of the two rotating shafts and the middle parts are respectively fixedly connected with scrapers, the outer walls of the rotating shafts and the left and right sides of the scrapers are respectively fixedly connected with fixing rings, the two ends of the rotating shaft are respectively sleeved with torsion springs, and the two ends of the torsion spring are respectively fixedly connected to the outer wall of the fixing ring and the inner wall of the hole box.

[0017] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the protection and fixing assembly includes a rotating rod, the inner wall of the connecting box is rotatably connected to two rotating rods, the middle part of the rotating rod is fixedly connected to a fixing ring, the outer wall of the rotating rod and the two sides of the middle part are respectively fixedly connected to gears, the inner wall of the connecting box is slidably connected to a plurality of racks, the gears are meshed with the outer walls of the racks, and the outer wall of the fixing ring is fixedly connected to a protective rod.

[0018] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the limiting component includes a fixed shell, the top of the connecting box and the two sides of the middle part are respectively fixedly connected with the fixed shell, the inner wall of the fixed shell is slidably connected with a pull rod, the bottom end of the pull rod is fixedly connected with a limiting tooth matched with the gear, the outer wall of the pull rod is fixedly connected with a sliding plate, the sliding plate is slidably connected to the inner wall of the fixed shell, the outer part of the pull rod is provided with a first spring, and the two ends of the first spring are respectively fixedly connected to the inner wall of the fixed shell and the outer wall of the sliding plate.

[0019] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the pressing assembly includes a pressing block, the inner wall of the connecting box is slidably connected with a pressing block adapted to the protective rod, the outer wall of the pressing block is fixedly connected with support plates on the front and rear sides respectively, the bottom of the support plate is fixedly connected with a plurality of sliding rods, the sliding rods are slidably connected to the inner wall of the connecting box, the outer sleeve of the sliding rod is provided with a second spring, and the two ends of the second spring are respectively fixedly connected to the outer wall of the support plate and the inner wall of the connecting box.

[0020] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the extrusion assembly includes a connecting plate, the bottom of the pressing block is rotatably connected to two connecting plates, the bottom ends of the two connecting plates are respectively rotatably connected to extrusion blocks, the two extrusion blocks are respectively slidably connected to the inner wall of the connecting box, the two extrusion blocks are respectively fixedly connected to a plurality of third springs on the sides away from each other, the ends of the plurality of third springs away from the extrusion blocks are all fixedly connected to the inner wall of the connecting box, third contact sensors are respectively fixedly installed on the tops of the two extrusion blocks, the two third contact sensors are adapted to each other, the two third contact sensors are both electrically connected to the controller, and the two extrusion blocks are close to each other and are tightly attached to a packaging bag.

[0021] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the detection component includes a measuring instrument, the inner wall of the connecting box is fixedly connected to the measuring instrument, the inner wall of the measuring instrument is electrically connected to a platinum resistance sensor, and the platinum resistance sensor is located in the packaging bag.

[0022] As a preferred embodiment of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention, the stirring mechanism includes a driver, the driver is fixedly installed on the outer wall of the constant temperature water bath, the inner wall of the constant temperature water bath is rotatably connected to a magnetic rotor, and the driver is adapted to the magnetic rotor.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The portable skin storage and rewarming system for batch burn treatment provided by the present invention can make the limiting tooth leave the corresponding gear by pulling the pull rod upward, and then the protection rod can be pulled to move the rack into the connection box. After both protection rods are pulled up, the connection box can be lifted up by relying on the protection rods, and then it can be quickly inserted into the appropriate position in the constant temperature water bath. After the connection box and the packaging bag are placed in the constant temperature water bath, the pull rod can be pulled to rotate the protection rod to the initial position, and then the connection box and the packaging bag are moved out of the inner box and then placed in the constant temperature water bath. The distance between the position of leaving the inner box and the position of placing in the constant temperature water bath is relatively close, and no regional operation is required during the transfer process, which shortens the transfer time, thereby reducing the possibility that the activity of the xenogeneic skin tissue sample in the packaging bag is damaged due to the long transfer time, thereby improving the practicability of the device, and during the transfer process, the connection box is driven to move by two protective rods, thereby avoiding frostbite on the operator's hands due to the low temperature of liquid nitrogen, thereby improving the safety of the device, and during the storage and transportation of the device, the protective rod protects the pressing block, reduces the possibility that the pressing block is accidentally pressed, and improves the stability of the device.

[0025] The portable skin storage and rewarming system for batch burn treatment provided by the present invention can move two squeezing blocks away from each other by pressing the pressing block, thereby releasing the squeezing of the packaging bag. This operation is relatively simple, so as to shorten the time for taking the skin graft out of the packaging bag for surgical transplantation after the skin graft is rewarmed, and avoid the situation where the activity of the skin graft after liquid nitrogen freezing and rewarming decreases rapidly over time, resulting in serious damage to the activity of the skin graft. The operation of simply and quickly separating the packaging bag from the connecting box greatly shortens the time used for taking out the rewarmed skin graft, thereby reducing the degree of damage to the activity of the skin graft, ensuring the effect of subsequent skin grafting, and improving the practicality of the device.

[0026] The portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention can drive the magnetic rotor to rotate through a driver, thereby making the water temperature inside the constant temperature water bath box more uniform, thereby making the surface temperature of the skin piece evenly rewarmed. At the same time, there is a vacuum layer between the liquid nitrogen freezing box and the inner box, which can reduce the heat transfer from the external environment to the tank body, so as to reduce the evaporation loss of liquid nitrogen. At the same time, the holes on the hole box allow liquid nitrogen or water to flow freely between the corresponding multiple hole boxes, thereby evenly freezing or rewarming the skin piece, and the device as a whole is relatively small and easy to carry.

[0027] The portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention makes the torsion spring close to the packaging bag through the rotating shaft under the action of the corresponding torsion spring, so that when the connecting box and the packaging bag are taken out of the inner box, the scraper can scrape off the liquid nitrogen remaining on the outside of the packaging bag. After the connecting box and the packaging bag leave the inner box, the two scrapers are closed to reduce the evaporation of liquid nitrogen. At the same time, during the process of the connecting box and the packaging bag entering the constant temperature water bath, the less liquid nitrogen remaining on the packaging bag will evaporate quickly. When the packaging bag is taken out of the liquid nitrogen, the liquid nitrogen on the packaging bag is scraped off, so as to avoid the situation where the packaging bag carries a relatively large amount of liquid nitrogen into the constant temperature water bath, resulting in a large change in the water temperature in the constant temperature water bath, thereby improving the rewarming efficiency of the skin flap. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the scheme of the present invention, a brief introduction is given below to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0029] Figure 1 A schematic diagram of the overall structure of a portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0030] Figure 2 A schematic diagram of the internal structure of a liquid nitrogen freezing box of a portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0031] Figure 3 A schematic diagram of a partially exploded structure of a portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0032] Figure 4 This is an enlarged structural schematic diagram of the storage mechanism of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0033] Figure 5 The portable skin storage and rewarming system for batch burn treatment provided by the present invention Figure 4 A magnified view of middle;

[0034] Figure 6 The portable skin storage and rewarming system for batch burn treatment provided by the present invention Figure 4 Enlarged view of middle B;

[0035] Figure 7 A schematic diagram of the internal structure of a connection box of a portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0036] Figure 8A schematic diagram of the internal structure of a fixed shell of a portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0037] Fig. 9 A schematic diagram of the internal structure of another connection box of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention;

[0038] Fig.10 The portable skin storage and rewarming system for batch burn treatment provided by the present invention Fig. 9 Enlarged view of middle C;

[0039] Fig.11 This is a schematic diagram of the enlarged structure of the detection component of the portable skin storage, transportation and rewarming system for batch burn treatment provided by the present invention.

[0040] The markings in the figure are as follows:

[0041] 1. Liquid nitrogen freezing box; 2. Insulation board; 3. Constant temperature water bath; 4. Controller; 5. Inner box; 6. Storage mechanism; 7. Pressure relief valve; 8. Stirring mechanism; 9. Driver; 10. Magnetic rotor; 11. Hole box; 12. Fluorine rubber ring; 13. Connection box; 14. First contact sensor; 15. Second contact sensor; 16. Fixed rod; 17. Rotating shaft; 18. Scraper; 19. Fixed ring; 20. Torsion spring; 21. Rotating rod ; 22. Fixed ring; 23. Gear; 24. Rack; 25. Protective rod; 26. Fixed shell; 27. Pull rod; 28. Limiting tooth; 29. ​​Sliding plate; 30. First spring; 31. Pressing block; 32. Support plate; 33. Sliding rod; 34. Second spring; 35. Connecting plate; 36. Extrusion block; 37. Third spring; 38. Third contact sensor; 39. Packaging bag; 40. Measuring instrument; 41. Platinum resistance sensor. DETAILED DESCRIPTION

[0042] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0043] As described in the background art, the time between taking out the skin graft from the liquid nitrogen storage device and putting it into the thawing device in the conventional device is relatively long. The long interval will damage the activity of the xenogeneic skin tissue sample, thereby causing poor healing after the skin graft is transplanted.

[0044] In order to solve this technical problem, the present invention provides a portable skin storage, transportation and rewarming system for batch burn treatment, which is used for gene-edited xenogeneic skin transplantation.

[0045] Specifically, please refer to Figure 1-Figure 4 The portable skin storage and rewarming system for batch burn treatment specifically includes:

[0046] Liquid nitrogen freezing area, thawing area and intelligent control IoT area;

[0047] The liquid nitrogen freezing area is used to freeze and preserve the skin slices. The liquid nitrogen freezing area includes a liquid nitrogen freezing box 1 and a temperature insulation board 2. The outer wall of the liquid nitrogen freezing box 1 is fixedly connected to the temperature insulation board 2. The inner wall of the liquid nitrogen freezing box 1 is fixedly installed with a controller 4. The inner wall of the liquid nitrogen freezing box 1 is fixedly connected to an inner box 5. A plurality of storage mechanisms 6 are arranged in the inner box 5. A pressure relief valve 7 is fixedly installed on the inner wall of the inner box 5.

[0048] The rewarming zone is used to thaw and rewarm the frozen skin slices, and the rewarming zone includes a constant temperature water bath 3. The side of the insulation board 2 away from the liquid nitrogen freezing box 1 is fixedly connected to the constant temperature water bath 3. A plurality of storage mechanisms 6 are arranged in the constant temperature water bath 3, and a stirring mechanism 8 is arranged on the constant temperature water bath 3.

[0049] The intelligent control IoT area includes the warehouse entry and exit record module, real-time monitoring module, location tracking module, operation record module, and information function record module;

[0050] In and out recording module: the time when the skin piece enters and leaves the skin tissue bank is recorded respectively, real-time monitoring module: monitors the water temperature in the constant temperature water bath 3, the water temperature is 4-37°C, position tracking module: real-time tracking and monitoring of the storage and transportation location of the skin piece, operation recording module: records the time when the skin piece is transferred from the liquid nitrogen freezing box 1 to the constant temperature water bath 3, and records the time period from the start of rewarming to the start of surgical transplantation, and records the time when the instantaneous rewarming temperature of the skin piece reaches the target rewarming temperature, information function module: records the skin piece number, ex vivo time and storage conditions.

[0051] The portable skin storage and rewarming system for batch burn treatment provided by the present invention can make the limiting tooth 28 leave the corresponding gear 23 by pulling the pull rod 27 upward, and then the protection rod 25 can be pulled to the rack 24 to move into the connecting box 13. After both protection rods 25 are pulled up, the connecting box 13 can be lifted up by relying on the protection rod 25, and then it can be quickly inserted into the appropriate position in the constant temperature water bath 3. After the connecting box 13 and the packaging bag 39 are placed in the constant temperature water bath 3, the pull rod 27 can be pulled to rotate the protection rod 25 to the initial position, and then the connecting box 13 and the packaging bag 39 are removed from the inner box 5 and then placed in the constant temperature water bath 3. The distance between the position where the connecting box 13 and the packaging bag 39 leave the inner box 5 and the position where they are placed in the constant temperature water bath 3 is relatively close, and no regional operation is required during the transfer process, which shortens the transfer time, thereby reducing the possibility that the activity of the heterogeneous skin tissue sample in the packaging bag 39 is damaged due to the long transfer time, thereby improving the practicality of the device, and during the transfer process, the two protection rods 25 are used to drive the connecting box 13 to move, thereby avoiding the situation where the operator's hands are frostbitten due to the low temperature of liquid nitrogen, thereby improving the safety of the device, and during the storage and transportation of the device, the protection rod 25 protects the pressing block 31, reduces the situation where the pressing block 31 is accidentally pressed, and improves the stability of the device.

[0052] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings.

[0053] Embodiment 1:

[0054] Please refer to Figure 4-Figure 11 , a portable skin storage and rewarming system for batch burn treatment, comprising:

[0055] The storage mechanism 6 includes a hole box 11, a fluororubber ring 12, a connection box 13, a monitoring component, a scraping component, a protection and fixing component, a limiting component, a pressing component, an extrusion component, and a detection component. The inner wall of the hole box 11 is tightly attached to the fluororubber ring 12, and the inner wall of the fluororubber ring 12 is fixedly connected to the connection box 13.

[0056] The monitoring component includes a first contact sensor 14. The first contact sensor 14 is fixedly installed on the top of the hole box 11. The second contact sensor 15 compatible with the first contact sensor 14 is fixedly installed on the top of the connection box 13. The first contact sensor 14 and the second contact sensor 15 are both electrically connected to the controller 4. The models of the first contact sensor 14 and the second contact sensor 15 are MTS series sensors respectively. The first contact sensor 14 and the second contact sensor 15 cooperate with each other and can send a signal to the controller 4 when the connection box 13 is placed in or leaves the hole box 11, so that the controller 4 can record the interval of the skin piece being taken out of the inner box 5 and transferred to the constant temperature water bath 3.

[0057] The scraping assembly includes a fixed rod 16, which is fixedly connected to the bottom of the connecting box 13 and near the left and right edges. The front and rear inner walls of the hole box 11 are rotatably connected with a rotating shaft 17, and the outer walls of the two rotating shafts 17 and the middle are respectively fixedly connected with a scraper 18, and the outer wall of the rotating shaft 17 and the left and right sides of the scraper 18 are respectively fixedly connected with a fixing ring 19, and the two ends of the rotating shaft 17 are respectively sleeved with a torsion spring 20, and the two ends of the torsion spring 20 are respectively fixedly connected to the outer wall of the fixing ring 19 and the inner wall of the hole box 11. The fixing ring 19 makes the corresponding scraper 18 close to the packaging bag 39, so as to facilitate the scraping of liquid nitrogen on the packaging bag 39. The skin treated with antifreeze and disinfectant is laid flat in the packaging bag 39 according to specifications, and the packaging bag 39 is sealed.

[0058] The protection and fixing assembly includes a rotating rod 21. Two rotating rods 21 are rotatably connected to the inner wall of the connecting box 13. A fixing ring 22 is fixedly connected to the middle of the rotating rod 21. Gears 23 are fixedly connected to the outer wall of the rotating rod 21 and located on both sides of the middle. A plurality of racks 24 are slidably connected to the inner wall of the connecting box 13. The gears 23 are meshed with the outer walls of the racks 24. A protection rod 25 is fixedly connected to the outer wall of the fixing ring 22. The protection rod 25 assists the operator in taking out the connecting box 13 to reduce the risk of frostbite on the operator's hands caused by liquid nitrogen. The folded protection rod 25 can also protect the pressing block 31 to reduce the risk of accidental pressing of the pressing block 31 during storage and transportation, thereby improving the safety of the device and the stability of transportation.

[0059] The limiting component includes a fixed shell 26, and the top of the connecting box 13 and the two sides of the middle are fixedly connected with the fixed shell 26 respectively. The inner wall of the fixed shell 26 is slidably connected with a pull rod 27, and the bottom end of the pull rod 27 is fixedly connected with a limiting tooth 28 adapted to the gear 23, and the bottom of the limiting tooth 28 has a tooth adapted to the corresponding gear 23. The outer wall of the pull rod 27 is fixedly connected with a sliding plate 29, and the sliding plate 29 is slidably connected to the inner wall of the fixed shell 26. The outer sleeve of the pull rod 27 is provided with a first spring 30, and the two ends of the first spring 30 are respectively fixedly connected to the inner wall of the fixed shell 26 and the outer wall of the sliding plate 29. A pull ring for easy pulling can be set on the top of the pull rod 27.

[0060] The pressing assembly includes a pressing block 31, the inner wall of the connection box 13 is slidably connected with a pressing block 31 adapted to the protection rod 25, the outer wall of the pressing block 31 is fixedly connected with support plates 32 on the front and rear sides respectively, the bottom of the support plate 32 is fixedly connected with a plurality of sliding rods 33, the sliding rods 33 are slidably connected to the inner wall of the connection box 13, the outer part of the sliding rods 33 is sleeved with a second spring 34, and the two ends of the second spring 34 are fixedly connected to the outer wall of the support plate 32 and the inner wall of the connection box 13 respectively.

[0061] The extrusion assembly includes a connecting plate 35, and the bottom of the pressing block 31 is rotatably connected to two connecting plates 35, and the bottom ends of the two connecting plates 35 are respectively rotatably connected to extrusion blocks 36, and the two extrusion blocks 36 are respectively slidably connected to the inner wall of the connection box 13. The sides of the two extrusion blocks 36 away from each other are respectively fixedly connected with multiple third springs 37, and the ends of the multiple third springs 37 away from the extrusion blocks 36 are all fixedly connected to the inner wall of the connection box 13, and the tops of the two extrusion blocks 36 are respectively fixedly installed with third contact sensors 38, and the two third contact sensors 38 are adapted to each other, and the two third contact sensors 38 are both electrically connected to the controller 4. The side of the two extrusion blocks 36 close to each other is tightly attached to a packaging bag 39, and the models of the two third contact sensors 38 are MTS series sensors.

[0062] The detection component includes a measuring instrument 40, the inner wall of the connection box 13 is fixedly connected to the measuring instrument 40, the inner wall of the measuring instrument 40 is electrically connected to a platinum resistance sensor 41, the platinum resistance sensor 41 is located in the packaging bag 39, the model of the platinum resistance sensor 41 can be RTD-100 or PT1000-insulation board 2, and the model of the measuring instrument 40 can be Data Logger DL-120.

[0063] The two gears 23 are then rotated, and the two corresponding racks 24 are thereby made to slide inside the connecting box 13, and finally the racks 24 are moved into the connecting box 13. Then the pull rod 27 is released, so that the pull rod 27 drives the limiting teeth 28 downward under the action of the elastic force of the first spring 30, so that the limiting teeth 28 are stuck on the corresponding gears 23 to limit the rotation of the rotating rod 21. After both the protecting rods 25 are pulled up, the connecting box 13 can be lifted up by the protecting rods 25, and then it can be quickly inserted into the appropriate position in the constant temperature water bath 3. After the packaging bag 39 is placed in the constant temperature water bath 3, the pull rod 27 can be pulled to rotate the protection rod 25 to the initial position. When the rewarmed skin graft needs to be taken out for transplantation, the protection rod 25 is unfolded and the rack 24 is retracted into the connection box 13. Then, the protection rod 25 is held to take the connection box 13 out of the constant temperature water bath 3. Then, the pressing block 31 is pressed down to drive the support plate 32 to slide inside the connection box 13, so that the sliding rod 33 at the bottom of the support plate 32 slides inside the connection box 13. Then, the second spring 34 is deformed, and the descent of the pressing block 31 drives the two connection plates 35 to push the extrusion blocks 36 away from each other under the restriction of the connection box 13. In this process, the third spring 37 is deformed, and the third contact sensor 38 is separated from the two extrusion blocks 36. Then, the packaging bag 39 can be taken out, and then the skin graft can be taken out from the packaging bag 39.

[0064] Embodiment 2:

[0065] The portable skin storage and rewarming system for batch burn treatment provided in Example 1 is further optimized. Specifically, Figure 3 As shown, the stirring mechanism 8 includes a driver 9 , the driver 9 is fixedly mounted on the outer wall of the constant temperature water bath 3 , the inner wall of the constant temperature water bath 3 is rotatably connected with a magnetic rotor 10 , and the driver 9 is adapted to the magnetic rotor 10 .

[0066] Through the above structural design, when the skin piece needs to be reheated, the temperature of the water inside the constant temperature water bath 3 is adjusted first, and then the driver 9 is controlled to drive the magnetic rotor 10 to rotate inside the constant temperature water bath 3, thereby driving the water inside the constant temperature water bath 3 to flow, so that the water temperature is uniform.

Claims

1. A portable skin storage and rewarming system for batch burn treatment, characterized in that: include: Liquid nitrogen freezing area, thawing area and intelligent control IoT area; The liquid nitrogen freezing area is used for freezing and preserving skin slices, and the liquid nitrogen freezing area comprises a liquid nitrogen freezing box (1) and a temperature insulation board (2), the outer wall of the liquid nitrogen freezing box (1) is fixedly connected to the temperature insulation board (2), the inner wall of the liquid nitrogen freezing box (1) is fixedly installed with a controller (4), the inner wall of the liquid nitrogen freezing box (1) is fixedly connected to an inner box (5), a plurality of storage mechanisms (6) are arranged in the inner box (5), and a pressure relief valve (7) is fixedly installed on the inner wall of the inner box (5); The rewarming zone is used to thaw and rewarm the frozen skin slices, and the rewarming zone comprises a constant temperature water bath (3). The side of the insulation board (2) away from the liquid nitrogen freezing box (1) is fixedly connected to the constant temperature water bath (3). A plurality of storage mechanisms (6) are arranged in the constant temperature water bath (3), and a stirring mechanism (8) is arranged on the constant temperature water bath (3); The intelligent control IoT area includes a storage entry and exit recording module, a real-time monitoring module, a location tracking module, an operation recording module, and an information function recording module; The entry and exit recording module records the time when the skin slice enters and leaves the skin tissue bank respectively; the real-time monitoring module monitors the water temperature in the constant temperature water bath (3), the water temperature is 4 to 37°C; the position tracking module tracks and monitors the storage and transportation position of the skin slice in real time; the operation recording module records the time when the skin slice is transferred from the liquid nitrogen freezing box (1) to the constant temperature water bath (3), and records the time period from the start of rewarming to the start of surgical transplantation, and records the time when the instantaneous rewarming temperature of the skin slice reaches the target rewarming temperature; the information function module records the number of the skin slice, the time of ex vivo removal and the storage conditions.

2. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 1 is characterized in that: The storage mechanism (6) comprises a hole box (11), a fluororubber ring (12), a connection box (13), a monitoring component, a scraping component, a protection and fixing component, a limiting component, a pressing component, an extrusion component, and a detection component. The inner wall of the hole box (11) is tightly attached to the fluororubber ring (12), and the inner wall of the fluororubber ring (12) is fixedly connected to the connection box (13).

3. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2 is characterized in that: The monitoring component comprises a first contact sensor (14), the top of the hole box (11) is fixedly mounted with the first contact sensor (14), the top of the connection box (13) is fixedly mounted with a second contact sensor (15) adapted to the first contact sensor (14), and the first contact sensor (14) and the second contact sensor (15) are both electrically connected to the controller (4).

4. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2 is characterized in that: The scraping assembly comprises a fixing rod (16), the fixing rod (16) is fixedly connected to the bottom of the connecting box (13) and near the left and right edges respectively, the front and rear inner walls of the hole box (11) are rotatably connected to the rotating shaft (17), the outer walls of the two rotating shafts (17) and the scrapers (18) are fixedly connected in the middle respectively, the outer walls of the rotating shafts (17) and the left and right sides of the scrapers (18) are fixedly connected respectively, and the two ends of the rotating shaft (17) are respectively sleeved with torsion springs (20), and the two ends of the torsion spring (20) are respectively fixedly connected to the outer wall of the fixing ring (19) and the inner wall of the hole box (11).

5. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2 is characterized in that: The protective fixing assembly comprises a rotating rod (21), the inner wall of the connecting box (13) is rotatably connected to two rotating rods (21), the middle part of the rotating rod (21) is fixedly connected to a fixing ring (22), the outer wall of the rotating rod (21) and the two sides of the middle part are respectively fixedly connected to gears (23), the inner wall of the connecting box (13) is slidably connected to a plurality of racks (24), the gears (23) are meshed on the outer wall of the racks (24), and the outer wall of the fixing ring (22) is fixedly connected to a protective rod (25).

6. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2 is characterized in that: The limiting component includes a fixed shell (26), the top of the connecting box (13) and the two sides of the middle part are fixedly connected with the fixed shell (26), the inner wall of the fixed shell (26) is slidably connected with a pull rod (27), the bottom end of the pull rod (27) is fixedly connected with a limiting tooth (28) adapted to the gear (23), the outer wall of the pull rod (27) is fixedly connected with a sliding plate (29), the sliding plate (29) is slidably connected to the inner wall of the fixed shell (26), the outer part of the pull rod (27) is provided with a first spring (30), and the two ends of the first spring (30) are respectively fixedly connected to the inner wall of the fixed shell (26) and the outer wall of the sliding plate (29).

7. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2 is characterized in that: The pressing assembly comprises a pressing block (31), the inner wall of the connection box (13) is slidably connected with a pressing block (31) adapted to the protection rod (25), the outer wall of the pressing block (31) is fixedly connected with support plates (32) at the front and rear sides respectively, the bottom of the support plate (32) is fixedly connected with a plurality of sliding rods (33), the sliding rods (33) are slidably connected to the inner wall of the connection box (13), the outer part of the sliding rods (33) is sleeved with a second spring (34), and the two ends of the second spring (34) are fixedly connected to the outer wall of the support plate (32) and the inner wall of the connection box (13), respectively.

8. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 7, characterized in that: The extrusion assembly comprises a connecting plate (35), the bottom of the pressing block (31) is rotatably connected to two connecting plates (35), the bottom ends of the two connecting plates (35) are respectively rotatably connected to extrusion blocks (36), the two extrusion blocks (36) are respectively slidably connected to the inner wall of the connection box (13), the sides of the two extrusion blocks (36) away from each other are respectively fixedly connected to a plurality of third springs (37), the ends of the plurality of third springs (37) away from the extrusion blocks (36) are all fixedly connected to the inner wall of the connection box (13), the tops of the two extrusion blocks (36) are respectively fixedly installed with third contact sensors (38), the two third contact sensors (38) are adapted to each other, and the two third contact sensors (38) are both electrically connected to the controller (4), and the sides of the two extrusion blocks (36) close to each other are tightly attached to a packaging bag (39).

9. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 2, characterized in that: The detection component comprises a measuring instrument (40), the inner wall of the connection box (13) is fixedly connected to the measuring instrument (40), the inner wall of the measuring instrument (40) is electrically connected to a platinum resistance sensor (41), and the platinum resistance sensor (41) is located in the packaging bag (39).

10. The portable skin storage, transportation and rewarming system for batch burn treatment according to claim 1, characterized in that: The stirring mechanism (8) comprises a driver (9), the driver (9) is fixedly mounted on the outer wall of the constant temperature water bath (3), the inner wall of the constant temperature water bath (3) is rotatably connected to a magnetic rotor (10), and the driver (9) is adapted to the magnetic rotor (10).

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