Nanoemulsion water-based insecticidal aerosol and preparation method thereof
By using surfactants in water-based insecticidal aerosols to form a stable nanoemulsion phase, combined with propellant, the problem of liquid phase stratification and poor efficacy is solved, and nano-level stability and significant biological stability are achieved The efficacy of the drug reduces the VOCs content and cost.
Patent Information
- Application Number
- CN202411321442.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-23
- Publication Date
- 2025-01-07
AI Technical Summary
The existing water-based insecticide aerosol is easily delaminated during storage and spraying, and the efficacy is not significant, and a large amount of cosolvent is required, resulting in high VOCs content, high cost and unfriendly environment.
The insecticidal components are dispersed in a system with water as a continuous phase by suitable surfactants to form a stable nanoemulsion phase, and combined with the propellant, a nanoemulsion-based insecticidal aerosol is prepared to avoid the use of co-solvents.
It has achieved a stable and uniform liquid phase system at the nano level, significantly improved the efficacy of biopharmaceuticals, reduced the VOCs content and cost, and is suitable for the prevention and control of domestic sanitary pests.
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Abstract
Description
Technical Field
[0001] The present application relates to the technical field of insecticides, and in particular to a nanoemulsion water-based insecticide aerosol and a preparation method thereof. Background Art
[0002] At present, household hygienic insecticide aerosol products are mainly divided into three types: oil-based aerosol, alcohol-based aerosol, and water-based aerosol. Among them, oil-based aerosol has the advantages of significant effect and ready to use, so most insecticide aerosol products on the market are oil-based insecticide aerosols with solvent oil as the carrier, while alcohol-based aerosols and water-based aerosols are relatively rare. However, in daily use scenarios, oil-based aerosols are easy to leave oil marks on the surface of objects after spraying. Although alcohol-based aerosols will not leave obvious oil marks on the surface of objects after use, they have the same composition as oil-based aerosols, have high VOCs content, are not environmentally friendly, and belong to Class 1 dangerous goods (according to GB30000.4-2013 "Chemical Classification and Labeling Specifications Part 4: Aerosols"), and have problems such as flammability and explosion. These problems make oil-based and alcohol-based insecticide aerosols face huge challenges in production, transportation, storage, sales, use, environmental protection, and sustainability.
[0003] In order to solve the shortcomings of oil-based and alcohol-based insecticide aerosols and adapt to the needs of green and sustainable development, insecticide aerosol manufacturers have invested in the development of water-based insecticide aerosol products. However, most water-based aerosols on the market are emulsions, which are thermally unstable systems and the liquid phase is prone to stratification after long-term storage. They are inconvenient to use and have relatively insignificant efficacy.
[0004] There are methods to improve the pain points of water-based aerosols. For example, there is a method that provides a homogeneous transparent water-based aerosol, which solubilizes the active ingredients through cosolvents such as alcohols to form a relatively stable microemulsion. On the one hand, this method contains too many alcohol solvents, with high VOCs content and low water content; on the other hand, it cannot achieve the desired nano-level efficacy, and is even inferior to the efficacy of water-based emulsions in traditional oil-in-water systems. The main reason is that aerosol spraying is a process of strong pressure and drastic temperature changes. In this process, the microemulsion is at risk of instability, and its liquid phase demulsifies during the spraying process to form an unstable emulsion, making the efficacy less than expected.
[0005] There are also methods to improve the excessive alcohol solvent content, using surfactants to form microemulsions to achieve a solubilization effect. Although this method reduces the content of alcohol solvents, the content of co-solvents used is still high, and there are also disadvantages such as high VOCs content and instability of the microemulsion during spraying, which reduces the efficacy of the drug. Summary of the invention
[0006] Based on this, the present application provides a nanoemulsion water-based insecticidal aerosol and a preparation method thereof which does not require the use of a cosolvent and has good stability during storage and spraying of the nano-microemulsion and good insecticidal effect.
[0007] In a first aspect of the present application, a nanoemulsion water-based insecticidal aerosol is provided, comprising a nanoemulsion and a propellant, wherein the continuous phase of the nanoemulsion is water, and the preparation raw materials further comprise components having the following mass percentages in the nanoemulsion water-based insecticidal aerosol: 0.1% to 2% of an insecticidal active ingredient and 0.01% to 2% of a nonionic surfactant;
[0008] The nonionic surfactant includes one or more of styrene acrylic acid polyether ester copolymer, polyoxyethylene alcohol ether, modified polycarboxylate, isomeric alcohol ether, sorbitan isostearate, sorbitan monooleate, laurel sorbitan, cetearyl alcohol polyether and stearyl alcohol polyether.
[0009] In one embodiment, the nonionic surfactant includes a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and sorbitan monooleate, a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and lauric sorbitan, a combination of isomeric alcohol ether, cetearyl alcohol polyether and sorbitan monooleate, or a combination of isomeric alcohol ether, stearyl alcohol polyether and sorbitan monooleate.
[0010] In one embodiment, the raw materials for preparing the nanoemulsion further include an anionic surfactant, and the mass percentage of the anionic surfactant in the nanoemulsion water-based insecticide aerosol is 0.01% to 2%.
[0011] In one embodiment, the anionic surfactant includes one or more of ethylene sulfonic acid copolymer sodium salt, itaconic acid-acrylic acid copolymer sodium salt, methyl vinyl ether-maleic anhydride copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
[0012] In one embodiment, the anionic surfactant includes a combination of ethylene sulfonic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, and a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
[0013] In one embodiment, the average particle size of the nanoemulsion is ≤100 nm.
[0014] In one embodiment, the mass percentage of the propellant in the nanoemulsion water-based insecticide aerosol is 40% to 50%.
[0015] In one embodiment, the insecticidal active ingredients include one or more of pyrethroid insecticides and nicotinoid insecticides.
[0016] The second aspect of the present application provides a method for preparing the nanoemulsion water-based insecticide aerosol, comprising the following steps:
[0017] Mixing raw materials for preparing the nanoemulsion and emulsifying to prepare the nanoemulsion;
[0018] The nanoemulsion and the propellant are loaded into an aerosol device.
[0019] In one embodiment, the steps of preparing the nanoemulsion include:
[0020] Mixing the insecticidal active ingredient with the nonionic surfactant to prepare a first mixture;
[0021] Add part of the water to the first mixture, heat to 80° C. to 90° C., stir and keep warm, to prepare a second mixture;
[0022] The remaining water is adjusted to a temperature of 10° C. to 20° C., and is added to the second mixture that is kept warm. When the temperature reaches 50° C. to 75° C., the addition is stopped, and stirring is continued for 5 min. to 15 min. The remaining water is then added to prepare the nanoemulsion.
[0023] or,
[0024] The insecticidal active ingredient is mixed with the nonionic surfactant and the anionic surfactant, and then melted and kept warm to prepare an oil phase;
[0025] The water is kept at a temperature of 40° C. to 95° C. and is added to the heat-insulated oil phase under stirring to prepare the nanoemulsion.
[0026] In order to solve the problems of liquid phase stratification during storage of traditional water-based nanoemulsion aerosols, liquid phase instability during aerosol spraying, poor biological efficacy of aerosols, and the use of a large amount of VOCs as solvents and cosolvents, etc. The present application uses a suitable type of surfactant to disperse the insecticide component in a system with water as a continuous phase to form a stable and uniform nanoemulsion phase, which is then combined with a propellant to form a nanoemulsion water-based insecticidal aerosol. The nanoemulsion water-based insecticidal aerosol has at least the following advantages:
[0027] (1) When the traditional aerosol uses water emulsion as the liquid phase, the dispersed droplets have the problem of thermal instability, and the water emulsion as the liquid phase is easy to separate into two phases during the storage of the aerosol, making the product inconvenient to use. In addition, the microemulsion is composed of droplets stabilized by the surfactant interface film, which is a thermodynamically stable isotropic liquid, but it can only maintain dynamic stability under specific composition ratios and environments, and the aerosol spraying process is a process of atomization and temperature change. The nanoemulsion water-based insecticidal aerosol described in the present application has a stable and uniform liquid phase system, and also has good stability when sprayed.
[0028] (2) The nanoemulsion water-based insecticide aerosol described in the present application does not require cosolvents, organic solvents and other substances, which solves the problem that a certain amount of solubilizers must be added when the traditional aerosol uses water emulsions and microemulsions as the liquid phase. Compared with the traditional method of water emulsions and microemulsions, which require the addition of a large amount of organic solvents and cosolvents during the preparation process, and the addition of solvent composition affects its HLB value to meet the formulation requirements, the present application can disperse the oil phase droplets to form a uniform system by means of phase inversion and phase transition temperature under suitable surfactant conditions. No solvent or cosolvent needs to be added in the intermediate process, the water content is high, the cost is low, and it is more environmentally friendly.
[0029] (3) The nanoemulsion water-based insecticide aerosol described in the present application has a significant effect on pest control, and the combination of nanoemulsion and aerosol significantly improves its biological efficacy. For contact insecticides, the atomization effect and the particle size of the active ingredient in the droplets are important factors affecting the efficacy. Generally speaking, the smaller the particle size of the active ingredient droplets, the larger the specific surface area, the larger the contact area, and the more significant the efficacy. Compared with the water emulsion (particle size is usually 0.3μm~5μm) of the coarse dispersion system in the traditional method, or other water-based aerosols of water emulsion type on the market (particle size is usually 10μm~20μm), and the microemulsion in the traditional method also has the risk of instability during the aerosol spraying process. After the microemulsion is unstable, it will form a coarse dispersion system similar to the emulsion. The droplets aggregate under the action of the free energy between the hydrophobic groups, and the particle size is further increased. The present application is nanometer-level, and in some embodiments it can be 10nm~100nm, and the particle size is significantly smaller. Moreover, the aerosol atomization particle size (aerosol atomization particle size is 20μm~50μm) is also smaller than the general application method (constant spray), so the pest control effect is more significant, and it is suitable for the control of common pests in household hygiene.
[0030] (4) The nanoemulsion water-based insecticidal aerosol described in the present application has good compatibility with different propellant systems. Since a non-ionic surfactant with a dual chemical structure is added to the nanoemulsion phase, it can be adapted to highly hydrophobic propellant systems such as propane and butane, and can maintain a mixed state for a certain period of time. Compared with traditional nanoemulsions, since a large amount of surfactants need to be added, the system is highly hydrophilic, which makes it more difficult to mix highly hydrophobic substances such as propane and butane in the aerosol, and the uniformity is very poor, which affects the overall efficacy of the aerosol, so the compatibility is poor. DETAILED DESCRIPTION
[0031] The nanoemulsion water-based insecticidal aerosol of the present application and its preparation method are further described in detail below in conjunction with specific examples. The present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.
[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.
[0033] As used herein, "one or more" refers to any one, any two, or any two or more of the listed items.
[0034] In this application, "the first aspect", "the second aspect", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or quantity, nor can they be understood as implicitly indicating the importance or quantity of the indicated technical features. Moreover, "the first", "the second", etc. only serve the purpose of non-exhaustive enumeration and description, and it should be understood that they do not constitute a closed limitation on quantity.
[0035] In the present application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.
[0036] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.
[0037] The percentage contents involved in this application, unless otherwise specified, refer to mass percentage for solid-liquid mixing and solid-solid mixing, and refer to volume percentage for liquid-liquid mixing.
[0038] The percentage concentrations mentioned in this application, unless otherwise specified, refer to the final concentration, which refers to the percentage of the added component in the system after the addition of the component.
[0039] The temperature parameters in this application, unless otherwise specified, allow for both constant temperature treatment and treatment within a certain temperature range. The constant temperature treatment allows the temperature to fluctuate within the accuracy range of instrument control.
[0040] The room temperature in this application generally refers to 4°C~30°C, preferably 20±5°C.
[0041] In some examples of the present application, a nanoemulsion water-based insecticidal aerosol is provided, comprising a nanoemulsion and a propellant, wherein the continuous phase of the nanoemulsion is water, and the preparation raw materials also include components having the following mass percentages in the nanoemulsion water-based insecticidal aerosol: 0.1% to 2% of an insecticidal active ingredient and 0.01% to 2% of a nonionic surfactant;
[0042] The nonionic surfactant includes one or more of styrene acrylic acid polyether ester copolymer, polyoxyethylene alcohol ether, modified polycarboxylate, isomeric alcohol ether, sorbitan isostearate, sorbitan monooleate, laurel sorbitan, cetearyl alcohol polyether and stearyl alcohol polyether.
[0043] Without limitation, the polyoxyethylene alcohol ether may include polyoxyethylene lauryl alcohol ether, polyoxyethylene (20) cetearyl alcohol ether, and the like.
[0044] Specifically, the mass percentage of the insecticidal active ingredient includes, but is not limited to, 0.1%, 0.3%, 0.5%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.7%, 2% or a range between any two of the foregoing.
[0045] Specifically, the mass percentage of the nonionic surfactant includes but is not limited to: 0.01%, 0.02%, 0.05%, 0.1%, 0.15%, 0.35%, 0.5%, 0.7%, 0.9%, 1%, 1.1%, 1.4%, 1.5%, 1.7%, 2% or a range between any two of the foregoing.
[0046] In some of these examples, the nonionic surfactant includes a combination of two, three or more of styrene acrylic acid polyether copolymer, polyoxyethylene alcohol ether, modified polycarboxylate, isomeric alcohol ether, sorbitan isostearate, sorbitan monooleate, laurel sorbitan, cetearyl alcohol polyether and stearyl alcohol polyether. Further, the nonionic surfactant includes a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and sorbitan monooleate, a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and laurel sorbitan, a combination of isomeric alcohol ether, cetearyl alcohol polyether and sorbitan monooleate, or a combination of isomeric alcohol ether, stearyl alcohol polyether and sorbitan monooleate. Through the reasonable combination of nonionic surfactants, a stable and uniform nanoemulsion phase can be effectively formed, and it also has good stability when sprayed, and the pest control effect is good.
[0047] In some of the examples, the raw materials for preparing the nanoemulsion also include anionic surfactants, and the mass percentage of the anionic surfactants in the nanoemulsion water-based insecticidal aerosol is 0.01% to 2%. Specifically, the mass percentage of the anionic surfactants includes but is not limited to: 0.01%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.5%, 2% or a range between any two of the foregoing. Through the reasonable combination of nonionic surfactants and anionic surfactants, a stable and uniform nanoemulsion phase can be effectively formed, and it also has good stability when sprayed, and has a good pest control effect.
[0048] In some examples, the anionic surfactant includes one or more of ethylene sulfonic acid copolymer sodium salt, itaconic acid-acrylic acid copolymer sodium salt, methyl vinyl ether-maleic anhydride copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
[0049] In some examples, the anionic surfactant includes a combination of two, three or more of ethylene sulfonic acid copolymer sodium salt, itaconic acid-acrylic acid copolymer sodium salt, methyl vinyl ether-maleic anhydride copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt. Further, the anionic surfactant includes a combination of ethylene sulfonic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, and a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
[0050] In some of the examples, the average particle size of the nanoemulsion is ≤100nm. Further, the average particle size of the nanoemulsion is 5nm~100nm. Specifically, the average particle size of the nanoemulsion includes but is not limited to: 5nm, 10nm, 15nm, 20nm, 25nm, 30nm, 35nm, 40nm, 45nm, 50nm, 55nm, 60nm, 65nm, 70nm, 75nm, 80nm, 85nm, 90nm, 95nm, 100nm or a range between any two of the foregoing. In some of the examples, the average particle size of the nanoemulsion is 5nm~90nm. In other examples, the average particle size of the nanoemulsion is 5nm~70nm. Without limitation, the average particle size refers to the average particle size obtained by the zata test.
[0051] In some examples, the dispersion index (PDI) of the nanoemulsion is ≤0.3. Further, the dispersion index (PDI) of the nanoemulsion is ≤0.2. Further, the dispersion index (PDI) of the nanoemulsion is ≤0.1.
[0052] In some examples, the mass percentage of the propellant in the nanoemulsion water-based insecticide aerosol is 40% to 50%. Without limitation, the propellant may include one or more of dimethyl ether, inert gas, propane and butane, etc.
[0053] In some examples, the insecticidal active ingredient includes one or more of pyrethroid insecticides and neonicotinoid insecticides.
[0054] Some other examples of the present application provide a method for preparing the nanoemulsion water-based insecticide aerosol, comprising the following steps:
[0055] Mixing raw materials for preparing the nanoemulsion and emulsifying to prepare the nanoemulsion;
[0056] The nanoemulsion and the propellant are loaded into an aerosol device.
[0057] In some examples, when only the nonionic surfactant is included, the steps of preparing the nanoemulsion include:
[0058] Mixing the insecticidal active ingredient with the nonionic surfactant to prepare a first mixture;
[0059] Add part of the water to the first mixture, heat to 80° C. to 90° C., stir and keep warm, to prepare a second mixture;
[0060] The remaining water is adjusted to a temperature of 10° C. to 20° C., and is added to the second mixture that is kept warm. When the temperature reaches 50° C. to 75° C., the addition is stopped, and stirring is continued for 5 min. to 15 min. The remaining water is then added to prepare the nanoemulsion.
[0061] In some examples, when the nonionic surfactant and the anionic surfactant are included, the insecticidal active ingredient is mixed with the nonionic surfactant and the anionic surfactant, and then melted and kept warm to prepare the oil phase;
[0062] The water is kept at a temperature of 40° C. to 95° C. and is added to the heat-insulated oil phase under stirring to prepare the nanoemulsion.
[0063] It can be understood that the method for preparing the nanoemulsion is a phase inversion emulsification method.
[0064] Without limitation, the temperature of the melt treatment is 50°C to 120°C.
[0065] For experimental parameters not specified in the following specific embodiments, reference is made to the instructions given in the present application document, and reference may also be made to experimental manuals in the art or other experimental methods known in the art, or to experimental conditions recommended by manufacturers.
[0066] The raw materials and reagents involved in the following specific examples can be obtained from commercial sources, or can be prepared by those skilled in the art according to known methods.
[0067] Example 1
[0068] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0069] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin, 0.4 g of ethylene sulfonic acid copolymer sodium salt, 0.6 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 0.1 g of polyoxyethylene lauryl alcohol ether were added to a stirring kettle, heated to 75° C. with stirring, to obtain 2.1 g of an oil phase.
[0070] (2) Deionized water was heated to 80°C and stirred thoroughly to obtain 107.9 g of aqueous phase.
[0071] (3) The 80°C water phase was added to a stirred kettle containing a 75°C oil phase while stirring to obtain 110 g of a liquid phase.
[0072] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and after inserting a valve, the can was sealed. 45 g of dimethyl ether was flushed into the aerosol can to obtain Sample Example 1.
[0073] Example 2
[0074] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0075] (1) 0.2 g of permethrin, 0.1 g of ethylene sulfonic acid copolymer sodium salt, 0.1 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 0.02 g of sorbitan isostearate were added to a stirring kettle, heated to 50° C. and stirred to obtain 0.42 g of an oil phase.
[0076] (2) Deionized water was heated to 70°C and stirred thoroughly to obtain 109.58 g of aqueous phase.
[0077] (3) The 70°C water phase was added to a stirred kettle containing a 50°C oil phase while stirring to obtain 110 g of a liquid phase.
[0078] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and after inserting a valve, the can was sealed. 45 g of propane and butane were then poured into the aerosol can to obtain Sample Example 2.
[0079] Example 3
[0080] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0081] (1) 2 g of imiprolin, 0.2 g of ethylene sulfonic acid copolymer sodium salt, 1.4 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 1 g of sorbitan isostearate were added to a stirring kettle, heated to 55° C. and stirred to obtain 4.6 g of an oil phase.
[0082] (2) Deionized water was heated to 65°C and stirred thoroughly to dissolve to obtain 105.4 g of aqueous phase.
[0083] (3) The 65°C water phase was added to a stirred kettle containing a 55°C oil phase while stirring to obtain 110 g of a liquid phase.
[0084] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and after inserting a valve, the can was sealed. 45 g of inert gas was flushed into the aerosol can to obtain Sample Example 3.
[0085] Example 4
[0086] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0087] (1) 2 g of cypermethrin, 2 g of permethrin, 2.2 g of itaconic acid-acrylic acid copolymer sodium salt, 1.8 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 0.4 g of sorbitan isostearate were added to a stirring kettle, heated to 90° C. with stirring, to obtain 5.8 g of an oil phase.
[0088] (2) Deionized water was heated to 85°C and stirred thoroughly to dissolve to obtain 104.2 g of aqueous phase.
[0089] (3) The 85°C water phase was added to a stirred kettle containing a 69°C oil phase while stirring to obtain 110 g of a liquid phase.
[0090] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and after inserting a valve, the can was sealed. 45 g of propane and butane were then poured into the aerosol can to obtain Sample Example 4.
[0091] Example 5
[0092] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0093] (1) 1.2 g of metofluthrin, 1.8 g of permethrin, 0.8 g of ethylene sulfonic acid copolymer sodium salt, 1.2 g of styrene-maleic anhydride copolymer sodium salt, and 0.2 g of sorbitan isostearate were added to a stirring kettle, heated to 69° C. with stirring, to obtain 5.2 g of an oil phase.
[0094] (2) Deionized water was heated to 85°C and stirred thoroughly to dissolve to obtain 94.8 g of aqueous phase.
[0095] (3) The 85°C water phase was added to a stirred kettle containing a 69°C oil phase while stirring to obtain 100 g of a liquid phase.
[0096] (4) Take 50 g of the liquid phase prepared in step (3) and pour it into an aerosol can. After inserting a valve, seal the can and flush 50 g of propane and butane into the aerosol can to obtain Sample Example 5.
[0097] Example 6
[0098] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0099] (1) 0.05 g of chlorfluanidine, 0.55 g of cypermethrin, 0.4 g of itaconic acid-acrylic acid copolymer sodium salt, 0.2 g of styrene-maleic anhydride copolymer sodium salt, and 0.3 g of sorbitan monooleate were added to a stirring kettle, heated to 55° C. with stirring, to obtain 1.5 g of an oil phase.
[0100] (2) Deionized water was heated to 60°C and stirred thoroughly to dissolve to obtain 98.5 g of aqueous phase.
[0101] (3) The 60°C water phase was added to a stirred kettle containing a 55°C oil phase while stirring to obtain 100 g of a liquid phase.
[0102] (4) Take 50 g of the liquid phase prepared in step (3) and pour it into an aerosol can. After inserting a valve, seal the can and flush 50 g of dimethyl ether into the aerosol can to obtain Sample Example 6.
[0103] Example 7
[0104] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0105] (1) 0.85 g of dextrorotatory phenothrin, 0.95 g of dextrorotatory phenothrin, 0.2 g of sodium salt of ethylene sulfonic acid copolymer, 0.2 g of sodium salt of styrene-maleic anhydride copolymer, 1.6 g of polyoxyethylene lauryl alcohol ether, and 0.4 g of sorbitan monooleate were added to a stirring vessel respectively, and the mixture was heated to 90° C. and stirred to obtain 4.2 g of an oil phase.
[0106] (2) Deionized water was heated to 80°C and stirred thoroughly to dissolve to obtain 95.8 g of aqueous phase.
[0107] (3) The 80°C water phase was added to a stirred kettle containing a 90°C oil phase while stirring to obtain 100 g of a liquid phase.
[0108] (4) Take 50 g of the liquid phase prepared in step (3) and pour it into an aerosol can. After inserting a valve, seal the can and flush 50 g of dimethyl ether into the aerosol can to obtain Sample Example 7.
[0109] Example 8
[0110] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0111] (1) 0.8 g of transfluthrin, 1.4 g of d-cypermethrin, 1.8 g of itaconic acid-acrylic acid copolymer sodium salt, 1.2 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 0.2 g of sorbitan monooleate were added to a stirring kettle, heated to 72° C. with stirring, to obtain 5.4 g of an oil phase.
[0112] (2) Deionized water was heated to 60°C and stirred thoroughly to dissolve to obtain 114.6 g of aqueous phase.
[0113] (3) The 60°C water phase was added to a stirred kettle containing a 72°C oil phase while stirring to obtain 120 g of a liquid phase.
[0114] (4) 60 g of the liquid phase prepared in step (3) was poured into an aerosol can, and after inserting a valve, the can was sealed. 40 g of dimethyl ether was flushed into the aerosol can to obtain Sample Example 8.
[0115] The key indicators and average particle sizes of the nanoemulsion water-based insecticidal aerosols of Examples 1-8 are summarized in Table 1 below:
[0116] Table 1
[0117]
[0118] Note: The average particle size test equipment is Malvern Nano ZS90 particle size potential analyzer.
[0119] Example 9
[0120] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0121] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin, 0.8 g of polyoxyethylene (20) cetostearyl alcohol ether, 0.4 g of stearyl alcohol polyether-21, 0.2 g of sorbitan monooleate and 40 g of deionized water were added to a stirring kettle, heated to 80° C. and stirred to obtain 42.6 g of a mixed solution A.
[0122] (2) Cool 12 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 54.6 g of mixed solution B, which is then stirred at 65° C. for 10 min.
[0123] (3) 55.4 g of 15° C. deionized water was added to the stirred tank containing the mixed solution B prepared in step (2) at 65° C. with stirring to obtain 110 g of a liquid phase.
[0124] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of propane and butane were poured into the aerosol can to obtain Sample Example 9.
[0125] Example 10
[0126] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0127] (1) 1 g of permethrin, 1 g of d-phenothrin, 1.8 g of polyoxyethylene (20) cetostearyl alcohol ether, 0.2 g of stearyl alcohol polyether-12, 0.2 g of sorbitan laurate and 40 g of deionized water were added into a stirring kettle, heated to 90° C. and stirred to obtain 44.2 g of a mixed solution A.
[0128] (2) Cool 30 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 74.2 g of mixed solution B, which is then kept at 60° C. and stirred for 10 min.
[0129] (3) 35.8 g of 15°C deionized water was added to the stirred tank containing the mixed solution B of step (2) at 60°C while stirring to obtain 110 g of liquid phase.
[0130] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of dimethyl ether was poured into the aerosol can to obtain Sample Example 10.
[0131] Embodiment 11
[0132] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0133] (1) 2 g of permethrin, 2 g of dinotefuran, 2 g of polyoxyethylene (20) cetearyl alcohol ether, 1.2 g of steareth-25, 0.2 g of sorbitan laurate and 40 g of deionized water were added into a stirring kettle, heated to 75° C. and stirred to obtain 45.4 g of a mixed solution A.
[0134] (2) Cool 33 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 78.4 g of mixed solution B. Maintain stirring at 50° C. for 10 min.
[0135] (3) Add 21.6 g of 15°C deionized water to the stirred tank containing the mixed solution B of step (2) at 50°C while stirring to obtain 100 g of liquid phase.
[0136] (4) 50 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 50 g of dimethyl ether was poured into the aerosol can to obtain Sample Example 11.
[0137] Example 12
[0138] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0139] (1) 2 g of cyfluthrin, 2 g of d-cypermethrin, 2 g of isomeric alcohol ether, 1.8 g of cetearyl alcohol polyether-25, 0.2 g of sorbitan monooleate and 35 g of deionized water were added to a stirring kettle, heated to 65° C. and stirred to obtain 41 g of a mixed solution A.
[0140] (2) Cool 41 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) of Example 12 to obtain 82 g of mixed solution B. Maintain the mixture at 40° C. and stir for 10 min.
[0141] (3) 18 g of 15°C deionized water was added to a stirred kettle containing the mixed solution B prepared in step (2) of Example 12 at 40°C while stirring to obtain 100 g of a liquid phase.
[0142] (4) 50 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 50 g of inert gas was flushed into the aerosol can to obtain Sample Example 12.
[0143] Embodiment 13
[0144] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0145] (1) 0.1 g of cyfluthrin, 0.1 g of permethrin, 0.1 g of isomeric alcohol ether, 0.05 g of ceteareth-20, 0.05 g of sorbitan monooleate and 30 g of deionized water were added to a stirring tank, heated to 80° C. with stirring, to obtain 30.4 g of a mixed solution A.
[0146] (2) Cool 20 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 50.4 g of mixed solution B, which is then kept at 60° C. and stirred for 10 min.
[0147] (3) 49.6 g of 15°C deionized water was added to the stirred tank containing the mixed solution B of step (2) at 60°C while stirring to obtain 100 g of liquid phase.
[0148] (4) 50 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 50 g of propane and butane were poured into the aerosol can to obtain Sample Example 13.
[0149] Embodiment 14
[0150] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0151] (1) 1.1 g of cyfluthrin, 1.9 g of permethrin, 1.9 g of isomeric alcohol ether, 0.7 g of ceteareth-20, 0.2 g of sorbitan monooleate and 30 g of deionized water were added to a stirring vessel, heated to 88° C. with stirring, to obtain 35.8 g of a mixed solution A.
[0152] (2) Cool 52 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 87.8 g of mixed solution B. Maintain stirring at 45° C. for 10 min.
[0153] (3) 32.2 g of 15°C deionized water was added to the stirred tank containing the mixed solution B of step (2) at 45°C while stirring to obtain 120 g of liquid phase.
[0154] (4) 60 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 40 g of propane and butane were poured into the aerosol can to obtain Sample Example 14.
[0155] Embodiment 15
[0156] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0157] (1) 0.9 g of imiprolin, 0.7 g of permethrin, 1 g of isomeric alcohol ether, 0.7 g of ceteareth-30, 0.1 g of sorbitan monooleate and 30 g of deionized water were added to a stirring kettle, heated to 95° C. with stirring, to obtain 33.4 g of a mixed solution A.
[0158] (2) Cool 16 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 49.4 g of mixed solution B, which is then stirred at 70° C. for 10 min.
[0159] (3) 70.6 g of 15°C deionized water was added to the stirred tank containing the mixed solution B of step (2) at 70°C while stirring to obtain 120 g of liquid phase.
[0160] (4) 60 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 40 g of inert gas was flushed into the aerosol can to obtain Sample Example 15.
[0161] Example 16
[0162] This embodiment provides a nanoemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0163] (1) 0.2 g of prallethrin, 0.4 g of dextrorotatory phenothrin, 0.3 g of isomeric alcohol ether, 0.2 g of stearyl alcohol polyether-21, 0.2 g of sorbitan monooleate and 30 g of deionized water were added to a stirring tank, heated to 85° C. with stirring, to obtain 31.3 g of a mixed solution A.
[0164] (2) Cool 18 g of deionized water to 15° C. and slowly add it to the mixed solution A in step (1) to obtain 49.3 g of mixed solution B, which is then kept at 60° C. and stirred for 10 min.
[0165] (3) 70.7 g of 15°C deionized water was added to the stirred tank containing the mixed solution B of step (2) at 60°C while stirring to obtain 120 g of liquid phase.
[0166] (4) 60 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 40 g of dimethyl ether was poured into the aerosol can to obtain Sample Example 16.
[0167] The key indicators and average particle sizes of the nanoemulsion water-based insecticide aerosols of Examples 9-16 are summarized in Table 2 below:
[0168] Table 2
[0169]
[0170] Note: The average particle size test equipment is Malvern Nano ZS90 particle size potential analyzer.
[0171] Comparative Example 1
[0172] This comparative example provides a microemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0173] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin and 2.6 g of fatty alcohol polyoxyethylene (9) ether were added to a stirred tank to obtain 23.6 g of an oil phase.
[0174] (2) Weigh deionized water to obtain 86.4 g of aqueous phase.
[0175] (3) The aqueous phase was added to the stirred tank containing the oil phase while stirring to obtain 110 g of a liquid phase.
[0176] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of dimethyl ether was poured into the aerosol can to obtain Comparative Example 1.
[0177] Comparative Example 2
[0178] This comparative example provides a microemulsion water-based aerosol, and the preparation method thereof comprises the following steps:
[0179] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin, 20 g of ethanol, and 2.6 g of fatty alcohol polyoxyethylene (9) ether were added to a stirred tank to obtain 23.6 g of an oil phase.
[0180] (2) Weigh deionized water to obtain 86.4 g of aqueous phase.
[0181] (3) The aqueous phase was added to the stirred tank containing the oil phase while stirring to obtain 110 g of a liquid phase.
[0182] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of dimethyl ether was poured into the aerosol can to obtain Comparative Example 2.
[0183] Comparative Example 3
[0184] This comparative example provides a water-based emulsion aerosol, and its preparation method comprises the following steps:
[0185] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin, 0.15 g of Tween 80, 0.2 g of Span 60, and 25 g of isopropyl myristate were added to a stirred tank, heated to 69° C. and stirred to obtain 26.35 g of an oil phase.
[0186] (2) Weigh deionized water to obtain 83.65 g of aqueous phase.
[0187] (3) The aqueous phase was added to the stirred tank containing the oil phase while stirring to obtain 110 g of liquid phase.
[0188] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of propane and butane were poured into the aerosol can to obtain Comparative Example 3.
[0189] Comparative Example 4
[0190] This comparative example provides a water-based aerosol emulsion, the preparation method of which comprises the following steps:
[0191] (1) 2 g of cyfluthrin, 2 g of d-cypermethrin, 0.05 g of Tween 80, 0.95 g of Span 60, and 45 g of isopropyl myristate were added to a stirred tank, heated to 69° C. and stirred to obtain 47.2 g of an oil phase.
[0192] (2) Weigh deionized water to obtain 62.8 g of aqueous phase.
[0193] (3) The aqueous phase was added to the stirred tank containing the oil phase while stirring to obtain 110 g of liquid phase.
[0194] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of dimethyl ether was poured into the aerosol can to obtain Comparative Example 4.
[0195] Comparative Example 5
[0196] This comparative example provides a nanoemulsion water-based aerosol, and its preparation method comprises the following steps:
[0197] (1) 0.50 g of prallethrin, 0.50 g of cypermethrin, 0.4 g of ethylene sulfonic acid copolymer sodium salt, 0.6 g of methyl vinyl ether-maleic anhydride copolymer sodium salt, and 0.1 g of polyoxyethylene lauryl alcohol ether were added to a stirring kettle, heated to 75° C. with stirring, to obtain 2.1 g of an oil phase.
[0198] (2) Deionized water was heated to 80°C and stirred thoroughly to obtain 107.9 g of aqueous phase.
[0199] (3) The 80°C water phase was added to a stirred kettle containing a 75°C oil phase while stirring to obtain 110 g of a liquid phase.
[0200] (4) Take 55 g of the liquid phase prepared in step (3) and place it in a normal spray bottle. Add 45 g of deionized water and screw the cap to obtain Comparative Example 5.
[0201] Comparative Example 6
[0202] This comparative example provides a traditional water-based aerosol, and its preparation method comprises the following steps:
[0203] (1) 0.32 g of prallethrin, 0.10 g of cypermethrin, 0.05 g of Tween 80, 0.2 g of Span 60, and 25 g of isopropyl myristate were added to a stirred tank, respectively, and stirred for 20 min to obtain 25.67 g of an oil phase.
[0204] (2) Weigh deionized water to obtain 84.33 g of aqueous phase.
[0205] (3) The aqueous phase was added to the stirred tank containing the oil phase while stirring to obtain 110 g of liquid phase.
[0206] (4) 55 g of the liquid phase prepared in step (3) was poured into an aerosol can, and the can was sealed after inserting a valve. 45 g of propane and butane were poured into the aerosol can to obtain Comparative Example 6.
[0207] Test Example 1 Homogeneous Stability Verification
[0208] The samples of Examples 1-8, 9-16 and Comparative Examples 1-4 were fully shaken and injected into glass aerosol can test tubes respectively, and then observed after standing for 24 hours. The observation results are shown in Table 3.
[0209] Table 3
[0210]
[0211] From the results in Table 3, it can be seen that the liquid phases of Examples 1-8 and 9-16 are all homogeneous liquids, and the results are compared with the more intuitive Examples 1, 9 and Comparative Examples:
[0212] After 24 hours of rest, the sample of Comparative Example 1 showed obvious stratification. The possible reason is that it could not directly emulsify the effective ingredients, resulting in stratification of the water phase and the oil phase.
[0213] Compared with Comparative Example 1, a certain amount of co-solvent was added in Comparative Example 2 to achieve the emulsification effect; compared with Example 1 and Example 9, Comparative Example 2 had a significantly higher VOCs content; after the aerosol was sprayed, the liquid of Comparative Example 2 was stationary for 24 hours, and the sample showed obvious stratification. The possible reasons are: the liquid of Comparative Example 1 is a microemulsion, and the temperature of the microemulsion changes greatly during the aerosol spraying process, resulting in stratification of the water phase and the oil phase.
[0214] Compared with Comparative Examples 3 and 4 and Example 12, the liquid phase and the gas phase of Example 12 are easier to mix, and the liquid phase will not become unstable due to the addition of propane and butane.
[0215] Test Example 2: Flammability Verification
[0216] Examples 1-8, 9-16 and Comparative Examples 1-4 were tested according to GB20578-2006 “Safety Specification for Classification, Warning Labels and Warning Statements of Chemicals - Flammable Aerosols”. The results are shown in Table 4.
[0217] Table 4 Sample flammability test
[0218]
[0219] From the results in Table 4, it can be seen that Examples 1, 2, 9, and 12 are all non-flammable, while Comparative Examples 1, 2, 3, and 4 have lower water contents and use a larger amount of ethanol, and the results show that the samples are flammable.
[0220] Test Example 3: Drug Efficacy Verification
[0221] Examples 1-5 and Comparative Examples 5-6 were tested for efficacy according to GB / T 13917.2-2009 “Indoor efficacy test and evaluation of public health insecticides for registered pesticides Part 2: Aerosols”, and the results are shown in Table 5.
[0222] Table 5
[0223]
[0224] From the results in Table 5, it can be seen that although Examples 1, 2, 9, and 12 have different active ingredients, they are all newer pyrethroids, have low resistance to insects, and their efficacy meets the standard requirements, and are better than Comparative Example 6 (traditional water-based aerosol). Compared with Example 1, Comparative Example 5 has similar ingredients, but the particle size of the constant spray droplets is larger, and the effect is significantly reduced compared with Example 1.
[0225] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0226] The above-described embodiments only express several implementation methods of the present application, which is convenient for understanding the technical solution of the present application in detail, but it cannot be understood as limiting the scope of protection of the patent application. It should be pointed out that for ordinary technicians in this field, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the scope of protection of the present application. It should be understood that the technical solutions obtained by those skilled in the art through logical analysis, reasoning or limited experiments on the basis of the technical solutions provided in the present application are all within the scope of protection of the claims attached to the present application. Therefore, the scope of protection of the patent of this application shall be based on the content of the attached claims, and the description can be used to interpret the content of the claims.
Claims
1. A nanoemulsion water-based insecticide aerosol, characterized in that: The invention comprises a nanoemulsion and a propellant, wherein the continuous phase of the nanoemulsion is water, and the preparation raw materials also include components having the following mass percentages in the nanoemulsion water-based insecticidal aerosol: 0.1% to 2% of an insecticidal active ingredient and 0.01% to 2% of a non-ionic surfactant; The nonionic surfactant includes one or more of styrene acrylic acid polyether ester copolymer, polyoxyethylene alcohol ether, modified polycarboxylate, isomeric alcohol ether, sorbitan isostearate, sorbitan monooleate, laurel sorbitan, cetearyl alcohol polyether and stearyl alcohol polyether.
2. The nanoemulsion water-based insecticide aerosol according to claim 1, characterized in that: The nonionic surfactant includes a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and sorbitan monooleate, a combination of polyoxyethylene alcohol ether, stearyl alcohol polyether and lauric sorbitan, a combination of isomeric alcohol ether, cetearyl alcohol polyether and sorbitan monooleate, or a combination of isomeric alcohol ether, stearyl alcohol polyether and sorbitan monooleate.
3. The nanoemulsion water-based insecticide aerosol according to claim 1, characterized in that: The raw materials for preparing the nanoemulsion also include anionic surfactants, and the mass percentage of the anionic surfactants in the nanoemulsion water-based insecticide aerosol is 0.01% to 2%.
4. The nanoemulsion water-based insecticide aerosol according to claim 3, characterized in that: The anionic surfactant includes one or more of ethylene sulfonic acid copolymer sodium salt, itaconic acid-acrylic acid copolymer sodium salt, methyl vinyl ether-maleic anhydride copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
5. The nanoemulsion water-based insecticidal aerosol according to claim 4, characterized in that: The anionic surfactant includes a combination of ethylene sulfonic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and methyl vinyl ether-maleic anhydride copolymer sodium salt, a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, a combination of itaconic acid-acrylic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt, and a combination of ethylene sulfonic acid copolymer sodium salt and styrene-maleic anhydride copolymer sodium salt.
6. The nanoemulsion water-based insecticide aerosol according to any one of claims 1 to 5, characterized in that: The average particle size of the nanoemulsion is ≤100 nm.
7. The nanoemulsion water-based insecticide aerosol according to any one of claims 1 to 5, characterized in that: The mass percentage of the propellant in the nanoemulsion water-based insecticide aerosol is 40% to 50%.
8. The nanoemulsion water-based insecticide aerosol according to any one of claims 1 to 5, characterized in that: The insecticidal active ingredients include one or more of pyrethroid insecticides and nicotine insecticides.
9. The method for preparing the nanoemulsion water-based insecticidal aerosol according to any one of claims 1 to 8, characterized in that: The steps include: Mixing raw materials for preparing the nanoemulsion and emulsifying to prepare the nanoemulsion; The nanoemulsion and the propellant are loaded into an aerosol device.
10. The method for preparing the nanoemulsion water-based insecticidal aerosol according to claim 9, characterized in that: The steps of preparing the nanoemulsion include: Mixing the insecticidal active ingredient with the nonionic surfactant to prepare a first mixture; Add part of the water to the first mixture, heat to 80° C. to 90° C., stir and keep warm, to prepare a second mixture; The remaining water is adjusted to a temperature of 10° C. to 20° C., and is added to the second mixture that is kept warm. When the temperature reaches 50° C. to 75° C., the addition is stopped, and stirring is continued for 5 min. to 15 min. The remaining water is then added to prepare the nanoemulsion. or, The insecticidal active ingredient is mixed with the nonionic surfactant and the anionic surfactant, and then melted and kept warm to prepare an oil phase; The water is kept at a temperature of 40° C. to 95° C. and is added to the heat-insulated oil phase under stirring to prepare the nanoemulsion.