Novel high-strength biocompatible tissue compensation glue

Abstract

The invention discloses novel high-strength biocompatible tissue compensation glue which is prepared from the following raw materials in parts by mass: modified SEBS (Styrene-Ethylene-Butylene-Styrene), naphthenic oil, a light stabilizer, an antioxidant, an antibacterial agent, a thickening agent and an anti-ultraviolet absorbent, the invention relates to an anti-ultraviolet plastic which is prepared from the following components in parts by weight: 5-10 parts of modified SEBS, 15-80 parts of naphthenic oil, 0.5-1 part of a light stabilizer, 0.5-1 part of an antioxidant, 1-1.5 parts of an antibacterial agent, 0.5-1 part of a thickening agent and 0-0.5 part of an anti-ultraviolet absorbent. According to the invention, the transparency is high, the accurate positioning of radiotherapy is ensured, the self-adhesion is strong, the tensile property is good, and the radiation dose uniformity is ensured by seamlessly fitting with any irradiated part of a human body.

Description

Technical Field

[0001] The invention relates to the field of medical radiotherapy and chemotherapy, and in particular to a novel high-strength biocompatible tissue compensation glue. Background Art

[0002] Radiotherapy has become an important means of cancer treatment. After high-energy radiation enters the human body, within a certain initial depth range, its depth dose gradually increases to form a dose build-up effect; tissue compensation glue is a special jelly designed to improve the effect of radiotherapy.

[0003] Traditional tissue compensation glue has slightly low transparency, poor tensile strength, and low skin adhesion, resulting in gaps between the tissue compensation glue and the skin, causing high-energy rays to cause secondary construction effects on the skin, aggravating skin damage. The colloid of the present invention has the characteristics of high transparency, strong self-adhesion, good tensile strength, etc., so that it can fit well to specific parts of the human body, such as the breast, head and other curved parts of the human body, providing better adhesion, thereby accurately positioning the radiotherapy area and calculating the dose, and enhancing the radiotherapy effect. Summary of the invention

[0004] The purpose of the invention is to provide a novel high-strength biocompatible tissue compensation glue with high transparency, high tensile strength and uniform density.

[0005] The object of the present invention is achieved as follows: a novel high-strength biocompatible tissue compensation glue, characterized in that the compensation glue comprises the following preparation raw materials by weight: modified SEBS, cyclohexane oil, light stabilizer, antioxidant, antibacterial agent, thickener, anti-ultraviolet absorber;

[0006] Modified SEBS: 5-10 parts;

[0007] Naphthenic oil: 15-80 parts;

[0008] Light stabilizer: 0.5-1 part;

[0009] Antioxidant: 0.5-1 part;

[0010] Antimicrobial agent: 1-1.5 parts;

[0011] Thickener: 0.5-1 part;

[0012] Anti-ultraviolet absorber: 0-0.5 parts.

[0013] Preferably, the antioxidant is nano-sized titanium dioxide.

[0014] Preferably, nanoparticles are added to the cycloalkane oil; and the antibacterial agent is nanosilver particles.

[0015] Preferably, the mass of the added cyclohexane oil is 3-8 times that of the modified SEBS.

[0016] A novel high-strength biocompatible tissue compensation glue, the preparation method of which is as follows:

[0017] S1: Weigh the following raw materials according to a specific mass ratio: modified SEBS, naphthenic oil, light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber;

[0018] S2: First, stir the modified SEBS and naphthenic oil evenly in a closed stirring container, slowly heat to 140-150°C, and stir to dissolve for half an hour;

[0019] S3: Add light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber, continue stirring and heat to 170-180° C., place in a reaction kettle, and obtain a reaction solution;

[0020] S4: placing the reaction solution in a vacuum degassing machine for air extraction and degassing to obtain a membrane preformed solution;

[0021] S5: The membrane prefabricated liquid is connected through an insulation pipe and transported to a special insulation mold with a nylon mesh cloth, and is formed into a set shape and size through hot pressing;

[0022] S6: After the incubator cools down to room temperature, the finished product is taken out of the hot press to obtain the final product, tissue compensation glue.

[0023] In the above composition, the use of cyclohexane oil innovatively replaces the traditional paraffin and white oil components, which can effectively improve the high transparency of the formed tissue compensation glue; adding nanoparticles to cyclohexane oil can not only greatly improve the softness, fit, transparency, but also increase the radiation resistance, stability and durability of the material; using titanium dioxide as an antioxidant to increase the service life of the tissue compensation glue; using a hot pressing process to bond the nylon mesh cloth to the tissue compensation glue greatly improves the tensile resistance. The combination of these components and the proportion of the components are obtained through a large number of experiments. The above combination and the proportion of the components make the tissue compensation glue formed by the present invention have the above-mentioned excellent properties of high transparency, strong self-adhesion and good tensile resistance. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a physical diagram of the present invention.

[0025] Figure 2 This is an enlarged view of the nylon mesh cloth structure of the present invention. DETAILED DESCRIPTION

[0026] The present invention is further illustrated by the following examples and comparative examples.

[0027] Example 1

[0028] S1: Weigh the following raw materials according to a specific mass ratio: 5 parts of modified SEBS, 15 parts of naphthenic oil, 0.8 parts of light stabilizer, 0.5 parts of antioxidant, 1.1 parts of antibacterial agent, 0.7 parts of thickener, and 0.4 parts of anti-ultraviolet absorber;

[0029] S2: First, stir the modified SEBS and naphthenic oil evenly in a closed stirring container, slowly heat to 140-150°C, and stir to dissolve for half an hour;

[0030] S3: Add light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber, continue stirring and heat to 170-180°C, place in a reaction kettle, and obtain a reaction solution;

[0031] S4: placing the reaction solution in a vacuum degassing machine for air extraction and degassing to obtain a membrane preformed solution;

[0032] S5: The membrane prefabricated liquid is connected through an insulation pipe and transported to a special insulation mold with a nylon mesh cloth, and is formed into a set shape and size through hot pressing;

[0033] S6: After the incubator cools down to room temperature, the finished product is taken out of the hot press to obtain the final product, tissue compensation glue.

[0034] Example 2

[0035] S1: Weigh the following raw materials according to a specific mass ratio: 6 parts of modified SEBS, 30 parts of naphthenic oil, 0.7 parts of light stabilizer, 0.5 parts of antioxidant, 1.1 parts of antibacterial agent, 0.7 parts of thickener, and 0.4 parts of anti-ultraviolet absorber;

[0036] S2: First, stir the modified SEBS and naphthenic oil evenly in a closed stirring container, slowly heat to 140-150°C, and stir to dissolve for half an hour;

[0037] S3: Add light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber, continue stirring and heat to 170-180° C., place in a reaction kettle, and obtain a reaction solution;

[0038] S4: placing the reaction solution in a vacuum degassing machine for air extraction and degassing to obtain a membrane preformed solution;

[0039] S5: The membrane prefabricated liquid is connected through an insulation pipe and transported to a special insulation mold with a nylon mesh cloth, and is formed into a set shape and size through hot pressing;

[0040] S6: After the incubator cools down to room temperature, the finished product is taken out of the hot press to obtain the final product, tissue compensation glue.

[0041] Example 3

[0042] S1: Weigh the following raw materials according to a specific mass ratio: 10 parts of modified SEBS, 80 parts of naphthenic oil, 0.7 parts of light stabilizer, 0.5 parts of antioxidant, 1 part of antibacterial agent, 0.7 parts of thickener, and 0.4 parts of anti-ultraviolet absorber;

[0043] S2: First, stir the modified SEBS and naphthenic oil evenly in a closed stirring container, slowly heat to 140-150°C, and stir to dissolve for half an hour;

[0044] S3: Add light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber, continue stirring and heat to 170-180° C., place in a reaction kettle, and obtain a reaction solution;

[0045] S4: placing the reaction solution in a vacuum degassing machine for air extraction and degassing to obtain a membrane preformed solution;

[0046] S5: The membrane prefabricated liquid is connected through an insulation pipe and transported to a special insulation mold with a nylon mesh cloth, and is formed into a set shape and size through hot pressing;

[0047] S6: After the incubator cools down to room temperature, the finished product is taken out of the hot press to obtain the final product, tissue compensation glue.

[0048] Comparative Example 1

[0049] Commercially available tissue compensation glue contains white oil or paraffin as filler.

[0050] Comparative Example 2

[0051] The preparation method of the tissue compensation glue of Comparative Example 2 refers to Example 2, except that there is no nylon mesh cloth in step S5, and the tissue compensation glue is directly taken out and cooled to room temperature.

[0052] The following performance tests were performed on the tissue compensation glue obtained in Examples 1-3 and Comparative Examples 1 and 2:

[0053] The tissue compensation glue was cut into 40mm×40mm blocks. The light transmittance of the tissue compensation glue was tested according to the national standard GB / T2410-2008. The sample thickness was 5mm. Three points were tested in the experiment and the average value was taken. The tensile strength of the tissue compensation glue was tested according to the national standard GB / T1701-2001. The sample thickness was 5mm. Three groups were tested in the experiment and the average value was taken. The tissue compensation glue was tested according to the national standards such as rubber density (GB 4472-84), initial viscosity (GB / T4852-2002), and peel viscosity (GB╱T 2792-2014). The test data are shown in Table 1:

[0054] Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Transmittance (%T) 93.3 93.4 93.4 91.6 93.5 Tensile strength(Mpa) 6.4 6.5 6.5 3.7 4.3 Density(g / cm3) 0.93 0.99 0.95 0.89 0.97 Initial adhesion(#) 10 12 11 6 11 Peel viscosity (g / cm) 14.4 16.3 15.7 5.6 16.0 Nylon mesh have have have none none

[0055] From the test results in Table 1, we can see that

[0056] Light transmittance: The light transmittances of Example 1, Example 2, and Example 3 are all high and close to each other. The light transmittances of Comparative Example 1 and Comparative Example 2 are also high, but slightly different from those of the embodiments. Comprehensive data show that the tissue compensation glue described in the present invention is superior to the compensation glue on the market in terms of light transmittance, thanks to the material composition and preparation process of the present application.

[0057] Tensile strength: The tensile strengths of Example 1, Example 2 and Example 3 are basically the same, and significantly higher than those of Comparative Example 1 and Comparative Example 2, which indicates that the materials in the examples have stronger tensile resistance, i.e., better mechanical strength. Thanks to the nylon mesh cloth hot pressing process of the present application, the tensile strength is further improved to avoid damage.

[0058] Density: The densities of Example 1, Example 2, and Example 3 are relatively close, and are all around 1.0, indicating that their density characteristics are relatively consistent. The density of Comparative Example 1 is slightly lower than that of the Example, and Comparative Example 2 is close to that of the Example, with little overall difference.

[0059] Initial tack: Example 2 has the highest initial tack, Example 1, Example 3, and Comparative Example 2 are slightly lower, and Comparative Example 1 has the lowest initial tack.

[0060] Peel viscosity: the peel viscosity of Example 1, Example 2 and Example 3 is relatively close, and significantly higher than that of Comparative Example 1. The peel viscosity of Comparative Example 2 is also relatively high, second only to that of Example 2. The peel viscosity reflects the ability of a material to resist separation during the peeling process. A higher peel viscosity generally means stronger adhesion and a longer-lasting adhesion effect.

[0061] In summary, the materials in the embodiments show better performance in terms of light transmittance, tensile strength, initial tack and peel viscosity than those in comparative example 1, and have high structural stability; comparative example 1 has weaker performance in light transmittance and peel viscosity, especially in tensile strength and initial tack, where the performance disadvantages are more obvious.

[0062] The above-described embodiments are merely descriptions of preferred implementations of the present invention, and are not intended to limit the concept and scope of the present invention. Without departing from the design concept of the present invention, various modifications and improvements made by ordinary persons in the art to the technical solution of the present invention should fall within the protection scope of the present invention, and the technical contents for which protection is sought in the present invention have been fully recorded in the claims.

Claims

1. A novel high-strength biocompatible tissue compensation glue, characterized in that: The compensating glue comprises the following raw materials by weight: modified SEBS, naphthenic oil, light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber; Modified SEBS: 5-10 parts; Naphthenic oil: 15-80 parts; Light stabilizer: 0.5-1 part; Antioxidant: 0.5-1 part; Antimicrobial agent: 1-1.5 parts; Thickener: 0.5-1 part; Anti-ultraviolet absorber: 0-0.5 parts.

2. A novel high-strength biocompatible tissue compensation glue according to claim 1, characterized in that: The antioxidant is nano-sized titanium dioxide.

3. The novel high-strength biocompatible tissue compensation glue according to claim 1, characterized in that: Nanoparticles are added into the naphthenic oil, and the nanoparticles are one or more of TiN, TiC and SiC nanoparticles; and the antibacterial agent is nanosilver particles.

4. The novel high-strength biocompatible tissue compensation glue according to claim 1, characterized in that: The mass of the added cyclohexane oil is 3-8 times that of the modified SEBS.

5. A method for preparing a novel high-strength biocompatible tissue compensation glue, characterized in that: The following steps are involved: S1: Weigh the following raw materials according to a specific mass ratio: modified SEBS, naphthenic oil, light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber; S2: First, stir the modified SEBS and naphthenic oil evenly in a closed stirring container, slowly heat to 140-150°C, and stir to dissolve for half an hour; S3: Add light stabilizer, antioxidant, antibacterial agent, thickener, and anti-ultraviolet absorber, continue stirring and heat to 170-180° C., place in a reaction kettle, and obtain a reaction solution; S4: placing the reaction solution in a vacuum degassing machine for air extraction and degassing to obtain a membrane preformed solution; S5: The membrane prefabricated liquid is connected through an insulation pipe and transported to a special insulation mold with a nylon mesh cloth, and is formed into a set shape and size through hot pressing; S6: After the incubator cools down to room temperature, the finished product is taken out of the hot press to obtain the final product, tissue compensation glue.

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