Water dropper, production system and production method for preparing multi-layer pill dropping agent

Abstract

The invention discloses a water dropper, a production system and a production method for preparing multi-layer dripping pills, and relates to the technical field of multi-layer dripping pill preparation. The water dropper comprises an inner-layer material guide pipe, a middle-layer material guide pipe and an outer-layer material guide pipe; a middle-layer material conveying channel is arranged between the middle-layer material guide pipe and the inner-layer material guide pipe, and an outer-layer material conveying channel is arranged between the outer-layer material guide pipe and the middle-layer material guide pipe; the inner-layer material guide pipe is communicated with the inner-layer material conveying pipe, and the inner-layer material conveying pipe is arranged in the inner-layer constant-temperature liquid heat preservation cavity; the middle-layer material conveying channel is communicated with a middle-layer material conveying pipe, and the middle-layer material conveying pipe is arranged in the middle-layer constant-temperature liquid heat preservation cavity; the outer-layer material conveying channel is communicated with an outer-layer material conveying pipe, and the outer-layer material conveying pipe is arranged in the outer-layer constant-temperature liquid heat preservation cavity. According to the invention, the temperature of each layer of material can be kept different and constant, each layer of material with uniform and reasonable proportion can synchronously flow out at the water dropper outlet, and a multi-layer pill dropping agent with a better effect can be produced.

Description

Technical Field

[0001] The invention relates to the technical field of multi-layer drop pill preparation, and in particular to a dropper, a production system and a production method for preparing the multi-layer drop pill. Background Art

[0002] At present, there are many studies on the physical and chemical encapsulation and controlled release of bioactive substances (probiotics, intestinal flora) at home and abroad, and most of them use a single or two-layer aqueous phase system for encapsulation and controlled release. For example, polysaccharides such as sodium alginate and chitosan are used, and proteins such as soy protein and gelatin are used for encapsulation; there are also oil substances such as propolis, shellac, hardened oils, animal and plant oils; there are also technologies such as the combination of two or more substances such as polysaccharide compounding, protein compounding, polysaccharide protein compounding, lipid and protein compounding; in addition, there are also technologies such as chemical modification to hydrophobicize hydrophilic substances such as polysaccharides and proteins, and the speed of controlled release is controlled by controlling the degree of hydrophobic modification. Most of these technologies use hydrophilic systems to disperse bioactive substances (such as probiotics and intestinal flora), which has a great impact on the stability and vitality of bioactive substances, greatly affecting the effect and yield, and increasing the cost; some technologies have more complicated processes, more steps, and are difficult to industrialize; in addition, most of these hydrophilic systems use single-layer single-phase or double-layer double-phase aqueous phase dispersion systems, which are difficult to ensure that bioactive substances (such as probiotics) are not activated, thereby affecting their stability. In addition, since bioactive substances are generally sensitive to gastric acid, the above processes have limited protective effects on active substances.

[0003] Dropping pills are a high-end dosage form in the field of pharmacy. Due to their special structure, they can give special properties to medicines. Dropping pills are small pill-shaped preparations made by heating, melting and mixing solid or liquid drugs with appropriate substances (generally called matrix), dropping them into immiscible condensate, shrinking and condensing, and are mainly used for oral administration. From the composition and preparation method of the drop pill, it has the following characteristics: 1. Simple equipment, convenient operation, conducive to labor protection, short process cycle and high productivity; 2. The process conditions are easy to control, the quality is stable, the dosage is accurate, the heating time is short, and the stability of easily oxidized and volatile drugs can be increased after being dissolved in the matrix; 3. The matrix can accommodate a large amount of liquid drugs, so the liquid drugs can be solidified, such as the rue oil drop pills with an oil content of up to 83.5%; 4. The drop pills prepared by solid dispersion technology have the characteristics of rapid absorption and high bioavailability. For example, the effective dose of griseofulvin drop pills is 1 / 4 of 100 mesh fine powder and 1 / 2 of micro powder (particle size below 5 microns); 5. New dosage forms for ear and eye drugs have been developed. Otorhinolaryngology preparations are mostly liquid or semi-solid dosage forms, and the action time is not long-lasting. The drop pills can have a prolonged effect.

[0004] Drop pills have the advantage of "three effects", which refer to rapid effect, high efficiency and long-term effect. Drop pills are mostly taken sublingually. The drug is directly absorbed through the sublingual mucosa and enters the blood circulation, avoiding the first-pass effect of the liver caused by swallowing and the degradation loss of the drug in the stomach, so that the drug can reach the target organ at a high concentration and take effect quickly. Generally, it will take effect within 5-15 minutes of sublingual administration, and no more than 30 minutes at most. Some also add sustained-release agents, which can significantly prolong the half-life of the drug and achieve the purpose of long-term effect. When needed, just hold it in your mouth.

[0005] The current types of pills are mainly as follows:

[0006] Fast-acting and high-efficiency dripping pills: The dripping pills are prepared using solid dispersion technology. When the matrix dissolves, the drug in the body is released in the form of fine crystals, amorphous particles or molecules, so it dissolves quickly, absorbs quickly, acts quickly, and has high bioavailability. A typical example of this type of product is the fast-acting heartache dripping pill.

[0007] Sustained-release and controlled-release pills: Sustained-release means that the drug in the pills dissolves slowly over a long period of time to achieve a long-lasting effect; controlled-release means that the drug dissolves at a constant rate in the pills, and its effect can last for more than several days, such as chloramphenicol controlled-release eye pills.

[0008] Solution drop pills: The lubricants and disintegrants used in tablets are mostly water-insoluble, so tablets cannot usually be used to prepare clear solutions. However, drop pills can be prepared with water-soluble matrices and can disintegrate into clear solutions in water. For example, Xibitai drop pills can be used for drinking water disinfection.

[0009] Suppository pills: Like water-soluble suppositories, pills can use water-soluble bases such as polyethylene glycol, and when used in the cavity, they are dissolved by body fluids to produce effects. Such as norfloxacin ear pills, metronidazole tooth pills, etc. Pills can also be used in the rectum, and can also be absorbed by the rectum and directly act on the whole body. They have the characteristics of high bioavailability and fast action.

[0010] Hard capsule pellets: pellets with different solubility can be loaded into hard capsules to form sustained-release pellet capsules with required solubility, such as hard capsule pellets of bifenthrin.

[0011] Coated pills: Like tablets and pills, they need to be coated with sugar or film, such as bifenthrin pills.

[0012] Liposome pellets: Liposomes are a suspension liquid and can be made into a solid dosage form using polyethylene glycol. Liposomes are added to molten polyethylene glycol 4000 under constant stirring to form a suspension, which is then poured into a mold to condense and form.

[0013] Dry-pressed coated pills: With the pill as the center, a coating composed of other drugs is pressed on it, which combines the advantages of two dosage forms, such as the antitussive and expectorant Kebiqing potassium chloride dry-pressed coated tablets. The former is the pill and the latter is the coating.

[0014] Classic dripping pills are not layered, and the dripping pills are a uniform mixture from the inside to the outside. With the development of preparations, there is a strong demand for the development of multi-layer dripping pills (such as three-layer dripping pills). The preparation process of these multi-layer dripping pills, such as double-layer dripping pills, is different from the soft capsules produced by the dripping method, because the contents of the soft capsules are liquid, while the internal components of the multi-layer dripping pills, such as three-layer dripping pills, are basically solid at room temperature. Therefore, the soft capsule production equipment / process cannot be applied to multi-layer dripping pills (such as three-layer dripping pills).

[0015] Based on this, there is an urgent need in the art for a device and / or its components that can drip into multi-layer, especially three-layer, dripping pills, and such a device can ensure the production effect of the dripping pills. Summary of the invention

[0016] The purpose of the present invention is to provide a dripper, a production system and a production method for preparing multi-layer drop pills, so as to solve the problems existing in the above-mentioned prior art, and can keep the temperature of each layer of materials different and constant during the drip production process, and can synchronously flow out uniform and reasonably proportioned layers of materials at the outlet of the dripper, so that the middle layer and the outer layer materials completely wrap the inner layer materials; can stably control the temperature of the coolant and the flow rate in the coolant circulation pipeline, and provide stable environmental conditions for the pill-making process; can stably dry and deoil the drop pills in a short time, and keep the roundness of the drop pills and the activity of the internal microorganisms or effective ingredients; thereby producing multi-layer drop pills with better effects.

[0017] To achieve the above object, the present invention provides the following solutions:

[0018] In one embodiment, a dripper for preparing multi-layer drop pills is introduced, comprising an inner material conduit, a middle material conduit and an outer material conduit which are sequentially sleeved on a coaxial line from inside to outside;

[0019] An annular middle-layer material conveying channel is formed between the middle-layer material conduit and the inner-layer material conduit, and an annular outer-layer material conveying channel is formed between the outer-layer material conduit and the middle-layer material conduit;

[0020] The inlet end of the inner material conduit is connected to the inner material conveying pipe, and the inner material conveying pipe is arranged in the inner constant temperature liquid insulation cavity;

[0021] The inlet end of the middle-layer material conveying channel is connected to the middle-layer material conveying pipe, and the middle-layer material conveying pipe is arranged in the middle-layer constant temperature liquid insulation cavity;

[0022] The inlet end of the outer material conveying channel is communicated with the outer material conveying pipe, and the outer material conveying pipe is arranged in the outer constant temperature liquid insulation cavity.

[0023] In one embodiment, the wall thickness of the outer material conduit is 1.0-6.0 mm, the wall thickness of the middle material conduit is 0.1-1.2 mm, the wall thickness of the inner material conduit is 0.1-1.2 mm, the inner radius r of the inner material conduit is 0.25-5.0 mm, the gap h1 between the middle material conduit and the inner material conduit is 0.2-2.0 mm, the gap h2 between the outer material conduit and the middle material conduit is 0.2-2.0 mm, and the ratio of h2, h1 and r is 1:(0.5-2):(1-4).

[0024] In one embodiment, the inner edge of the outlet end of the outer material conduit is chamfered.

[0025] In another embodiment, a multi-layered drop pill production system is introduced, including a material supply device, a dripper, a circulating cooling device, a pill-liquid separation device, and a drying and de-oiling machine;

[0026] The dripper is the dripper for preparing multi-layer dripping pills as described above;

[0027] The material supply device comprises an inner layer material supply device, a middle layer material supply device and an outer layer material supply device;

[0028] The discharge port of the inner layer material supply device is in communication with the inner layer material conveying pipe, and is used to convey the inner layer material to the inner layer material conduit through the inner layer material conveying pipe;

[0029] The discharge port of the middle-layer material supply device is in communication with the middle-layer material conveying pipe, and is used to convey the middle-layer material to the middle-layer material conveying channel through the middle-layer material conveying pipe;

[0030] The discharge port of the outer layer material supply device is in communication with the outer layer material conveying pipe, and is used to convey the outer layer material to the outer layer material conveying channel through the outer layer material conveying pipe;

[0031] The outlet end of the dripper leads to the circulating cooling device, and the material dripping from the dripper solidifies in the cooling liquid of the circulating cooling device to form three-layer drop pills, and the drop pills are transported to the pill-liquid separation device along with the circulating cooling liquid to separate the drop pills from the cooling liquid;

[0032] The drying and deoiling machine is used for drying and deoiling the separated dropping pills.

[0033] In one embodiment, the inner layer material supply device is provided with an inner layer material constant temperature spacer, and the inner layer material constant temperature spacer is connected to the inner layer constant temperature liquid insulation cavity;

[0034] The middle-layer material supply device is provided with a middle-layer material constant temperature spacer outside, and the middle-layer material constant temperature spacer is connected with the middle-layer constant temperature liquid insulation cavity;

[0035] The outer layer material supply device is provided with an outer layer material constant temperature isolation jacket outside, and the outer layer material constant temperature isolation jacket is communicated with the outer layer constant temperature liquid insulation cavity.

[0036] In one embodiment, the drying and deoiling machine includes a sealed box and a drying cage assembly, the top of the sealed box is provided with an openable sealing cover, one side of the sealed box is provided with an air inlet for introducing dry air, and the other side is provided with an exhaust port, the drying cage assembly is arranged in the sealed box, the drying cage assembly includes a drying cage, a cage drive motor, an air collecting box and a fan, the drying cage is rotatably connected in the sealed box and driven to rotate by the cage drive motor, the air collecting box is arranged under the drying cage and connected to the fan, the air collecting box is used to guide the air generated by the fan into the drying cage, and a deoiling cloth is placed in the drying cage for deoiling the pills.

[0037] In one embodiment, the inner layer material supply device includes an inner layer material tank, the inner layer material tank is fixedly installed in the inner layer material constant temperature jacket, the inner layer material constant temperature jacket is placed on the inner layer material weighing sensor, the bottom discharge port of the inner layer material tank is connected to the inner layer material conveying pipe, and the inner layer material conveying pipe is provided with an inner layer material tank bottom valve and an inner layer material pump;

[0038] The middle-layer material supply device comprises a middle-layer material tank, which is fixedly installed in the middle-layer material constant temperature spacer, and the middle-layer material constant temperature spacer is placed on the middle-layer material weighing sensor. The bottom discharge port of the middle-layer material tank is connected to the middle-layer material conveying pipe, and the middle-layer material conveying pipe is provided with a middle-layer material tank bottom valve and a middle-layer material pump;

[0039] The outer layer material supply device comprises an outer layer material tank, the outer layer material tank is fixedly installed in the outer layer material constant temperature isolation jacket, the bottom discharge port of the outer layer material tank is connected to the outer layer material conveying pipe, and the outer layer material conveying pipe is provided with an outer layer material tank bottom valve and an outer layer material pump;

[0040] The inner material tank and the middle material tank are both provided with homogenizing stirring paddles, the homogenizing stirring paddles are provided with homogenizing stirring sleeves outside, the outer material tank is provided with stirring paddles, and the homogenizing stirring paddles and the stirring paddles are respectively driven to rotate by driving motors.

[0041] In one embodiment, the homogenizing stirring paddle includes a driving rod, a stator and a rotor, the output shaft of the driving motor is connected to one end of the driving rod, the other end of the driving rod is connected to the rotor, and the stator is sleeved outside the rotor.

[0042] In one embodiment, the pill-liquid separation device includes a pill-liquid separation filter and a coolant recovery tray arranged below the pill-liquid separation filter, the circulating cooling device includes a cooling box, a coolant circulation pipeline, a coolant refrigeration storage box and a refrigeration stirring device, the outlet end of the dripper leads to the cooling box, one end of the coolant circulation pipeline is connected to the cooling box, and the other end leads to the pill-liquid separation filter, the coolant outlet of the coolant recovery tray leads to the coolant refrigeration storage box, the refrigeration stirring device is connected to the coolant refrigeration storage box, and is used to cool and stir the coolant in the coolant refrigeration storage box, the coolant refrigeration storage box is connected to the cooling box through a coolant supply pipeline, and a coolant circulation pump is provided on the coolant supply pipeline.

[0043] In one embodiment, the refrigeration stirring device includes a coolant stirring device, a cooling coil and a refrigerator, the cooling coil is arranged in the coolant refrigeration storage box, and the two ports of the cooling coil are connected to the refrigerator; the coolant stirring device includes a coolant stirring paddle, a driving connecting rod and a stirring driving motor, the output shaft of the stirring driving motor is connected to one end of the driving connecting rod, and the other end of the driving connecting rod is connected to the coolant stirring paddle, and the coolant stirring paddle is arranged in the internal space formed by the cooling coil.

[0044] In another embodiment, a multi-layered drop pill production method is introduced, based on the multi-layered drop pill production system described above, comprising the following steps:

[0045] The outer material constant temperature spacer and the insulating liquid in the outer constant temperature liquid insulation cavity are temperature-controlled, the middle material constant temperature spacer and the insulating liquid in the middle constant temperature liquid insulation cavity are temperature-controlled, and the inner material constant temperature spacer and the insulating liquid in the inner constant temperature liquid insulation cavity are temperature-controlled;

[0046] Put the outer layer material into the outer layer material tank, the middle layer material into the middle layer material tank, and the inner layer material into the inner layer material tank;

[0047] The outer layer material in the outer layer material tank, the middle layer material in the middle layer material tank, and the inner layer material in the inner layer material tank are transported to the dripper, and the materials of each layer flow into the coolant simultaneously from the outlet end of the dripper;

[0048] The outer layer material, the middle layer material and the inner layer material are solidified in the cooling liquid to obtain three-layer pellets, and then the pellets and the cooling liquid are separated by the pellet-liquid separation device;

[0049] The separated pellets are dried and deoiled by the drying and deoiling machine.

[0050] Compared with the prior art, the present invention has achieved the following technical effects:

[0051] The dripper for preparing multi-layer drop pills provided by the present invention can make the temperatures of the inner layer material, the middle layer material and the outer layer material different by respectively controlling the constant temperature of the insulation liquid in the inner layer constant temperature liquid insulation cavity, the middle layer constant temperature liquid insulation cavity and the outer layer constant temperature liquid insulation cavity, and the temperature of each layer of material is kept constant, thereby improving the stability of the drop pills during molding, thereby producing drop pills with better effects.

[0052] The multi-layered drop pill production system and production method provided by the present invention can make the temperatures of the inner layer material, the middle layer material and the outer layer material different, and keep the temperature of each layer of material constant, thereby improving the stability of the drop pill during molding, and can stabilize the temperature of the coolant during the drop pill molding through a circulating cooling device, and the drop pills after cooling and molding are separated from the coolant through a pill-liquid separation device, and then dried and deoiled through a drying and deoiling machine, thereby producing drop pills with better effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0054] Figure 1 This is a schematic diagram of the structure of Huanglong Drop Pills;

[0055] Figure 2 This is a cross-sectional view of Huanglong Drop Pills;

[0056] Figure 3 is a schematic structural diagram of a dripper according to one or more embodiments;

[0057] Figure 4 is a schematic structural diagram of a three-layer material conduit in a dripper according to one or more embodiments;

[0058] Figure 5 for Figure 4 A partial enlarged schematic diagram of part A;

[0059] Figure 6 is a schematic cross-sectional view of a three-layer material conduit in a dripper according to one or more embodiments;

[0060] Figure 7 A schematic diagram of the working principle of a multi-layered drop pill production system according to one or more embodiments;

[0061] Figure 8 is a schematic structural diagram of a homogenizing and stirring device according to one or more embodiments;

[0062] Fig. 9 is a schematic diagram of an exploded structure of a homogenizing and stirring device according to one or more embodiments;

[0063] Fig.10 is a schematic structural diagram of a refrigeration stirring device according to one or more embodiments;

[0064] Fig.11 A schematic diagram of the working principle of a dry deoiling machine according to one or more embodiments;

[0065] Fig.12 is a schematic structural diagram of a dry deoiling machine according to one or more embodiments;

[0066] Fig.13 is a schematic structural diagram of a drying cage assembly according to one or more embodiments;

[0067] Fig.14 It is a schematic structural diagram of a sealed box according to one or more embodiments.

[0068] In the figure: 100-drip head, 200-multi-layer drip pill production system, 300-Huanglong drip pill, 301-inner layer, 302-middle layer, 303-outer layer, 1-inner layer material conduit, 2-middle layer material conduit, 3-outer layer material conduit, 4-middle layer material conveying channel, 5-outer layer material conveying channel, 6-inner layer material conveying pipe, 7-inner layer constant temperature liquid insulation cavity, 8-middle layer material conveying pipe, 9-middle layer constant temperature liquid insulation cavity, 10-outer layer material conveying pipe, 11-outer layer constant temperature liquid insulation cavity, 12-chamfer, 1 3-Material supply device, 131-Inner material supply device, 1310-Inner material tank, 132-Middle material supply device, 1320-Middle material tank, 133-Outer material supply device, 1330-Outer material tank, 14-Circulating cooling device, 141-Cooling box, 142-Cooling liquid circulation pipeline, 143-Cooling liquid refrigeration storage box, 144-Refrigeration stirring device, 1440-Cooling liquid stirring device, 14401-Cooling liquid stirring paddle, 14402-Drive connecting rod, 14403-Stirring Drive motor, 1441-cooling coil, 1442-refrigeration machine, 145-coolant supply pipeline, 146-coolant circulation pump, 15-pill-liquid separation device, 151-pill-liquid separation filter, 152-coolant recovery plate, 16-inner material constant temperature spacer, 17-middle material constant temperature spacer, 18-outer material constant temperature spacer, 19-pill, 20-drying deoiling machine, 210-sealed box, 211-sealed cover, 212-air inlet, 213-exhaust port, 220-drying cage assembly, 221-dry Drying cage, 222-cage driving motor, 223-wind collecting box, 224-fan, 225-frame, 21-inner material weighing sensor, 22-inner material tank bottom valve, 23-inner material pump, 24-middle material weighing sensor, 25-middle material tank bottom valve, 26-middle material pump, 27-outer material tank bottom valve, 28-outer material pump, 29-homogeneous stirring paddle, 291-driving rod, 292-stator, 293-rotor, 30-driving motor, 31-homogeneous stirring sleeve, 32-stirring paddle. DETAILED DESCRIPTION

[0069] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0070] The purpose of the present invention is to provide a dripper, a production system and a production method for preparing multi-layer drop pills, so as to solve the problems existing in the prior art, keep the material temperature constant during the drip production process, and produce drop pills with better effects.

[0071] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0072] Embodiment 1

[0073] like Figure 3-Figure 6 As shown, this embodiment provides a dripper 100 for preparing multi-layer dripping pills, which can be prepared Figure 1-Figure 2 The Huanglong Pill 300 shown in the figure has a three-layer structure, with the inner layer 301 being the fecal bacteria raw material, the middle layer 302 being the protective layer, and the outer layer 303 being the membrane, which is resistant to gastric acid and bile and can deliver the live bacteria in the fecal bacteria raw material to the intestinal tract for release, thereby achieving the effect of fecal bacteria transplantation.

[0074] In some embodiments, the dripper 100 for preparing multi-layer drop pills includes an inner material conduit 1, a middle material conduit 2, and an outer material conduit 3 which are coaxially arranged in sequence from inside to outside;

[0075] The inlet end of the inner material conduit 1 is higher than the inlet ends of the middle material conduit 2 and the outer material conduit 3, and the inlet end of the middle material conduit 2 is higher than the inlet end of the outer material conduit 3;

[0076] An annular middle-layer material conveying channel 4 is formed between the middle-layer material conduit 2 and the inner-layer material conduit 1, and an annular outer-layer material conveying channel 5 is formed between the outer-layer material conduit 3 and the middle-layer material conduit 2;

[0077] The inlet end of the inner material conduit 1 is connected to the inner material conveying pipe 6, and the inner material conveying pipe 6 is arranged in the inner constant temperature liquid insulation cavity 7;

[0078] The inlet end of the middle-layer material conveying channel 4 is connected to the middle-layer material conveying pipe 8, and the middle-layer material conveying pipe 8 is arranged in the middle-layer constant temperature liquid insulation cavity 9;

[0079] The inlet end of the outer material conveying channel 5 is communicated with the outer material conveying pipe 10 , and the outer material conveying pipe 10 is arranged in the outer constant temperature liquid insulation cavity 11 .

[0080] By providing an inner constant temperature liquid insulation cavity 7, a middle constant temperature liquid insulation cavity 9 and an outer constant temperature liquid insulation cavity 11, each cavity can be filled with insulation liquid. When preparing multi-layered dropping pills, by respectively controlling the insulation liquids in the inner constant temperature liquid insulation cavity 7, the middle constant temperature liquid insulation cavity 9 and the outer constant temperature liquid insulation cavity 11, the temperatures of the inner layer material, the middle layer material and the outer layer material can be different, and the temperature of each layer of material can be kept constant, thereby improving the stability of the dropping pills during molding, thereby producing dropping pills with better effects.

[0081] In some embodiments, the wall thickness of the outer material conduit 3 is 1.0-6.0 mm, the wall thickness of the middle material conduit 2 is 0.1-1.2 mm, the wall thickness of the inner material conduit 1 is 0.1-1.2 mm, the inner radius r of the inner material conduit 1 is 0.25-5.0 mm, the gap h1 between the middle material conduit 2 and the inner material conduit 1 is 0.2-2.0 mm, the gap h2 between the outer material conduit 3 and the middle material conduit 2 is 0.2-2.0 mm, and the ratio of h2, h1 and r is 1:(0.5-2):(1-4).

[0082] In some embodiments, the wall thickness of the outer material conduit 3 is 2 mm, the wall thickness of the middle material conduit 2 is 0.4 mm, the wall thickness of the inner material conduit 1 is 0.4 mm, the inner radius r of the inner material conduit 1 is 1.2 mm, the gap h1 between the middle material conduit 2 and the inner material conduit 1 is 0.9 mm, the gap h2 between the outer material conduit 3 and the middle material conduit 2 is 0.6 mm, and the ratio of h2, h1 and r is 1:1.5:2.

[0083] The size of the dripper mainly refers to the inner radius of the outer material conduit 3. The inner radius of the outer material conduit 3 will affect the particle size of the pellets. Generally speaking, the larger the dripper, the larger the particle size of the produced pellets. Similarly, the size of the gap (h1 and h2) affects the thickness of the current layer. In order to produce reasonable pellets, it is generally necessary to set appropriate gaps between each layer. In actual production, the various parameter values ​​of the dripper can be set accordingly according to the specifications of the pellets to be prepared.

[0084] In some embodiments, a chamfer 12 is provided at the inner edge of the outlet end of the outer material conduit 3. By setting the chamfer 12, the size of the outlet end of the outer material conveying channel 5 can be increased, so that the material can flow into the coolant more smoothly, avoiding the accumulation of material at the outlet end due to part processing burrs or material adhesion, and reducing the resistance of the material when it flows out into the coolant, avoiding a certain point at the outlet of the outer material conveying channel 5 from being blocked or the gap being narrowed to affect the wrapping effect of the outer material during pilling, thereby improving the uniformity of material distribution and thus improving the molding effect of the drop pills.

[0085] Embodiment 2

[0086] like Figure 7-Figure 14 As shown, this embodiment provides a multi-layer drop pill production system 200, including a material supply device 13, a dripper 100 for preparing multi-layer drop pills as described in the first embodiment, a circulating cooling device 14, a pill-liquid separation device 15 and a drying and de-oiling machine 20;

[0087] The material supply device 13 includes an inner material supply device 131, a middle material supply device 132 and an outer material supply device 133;

[0088] The discharge port of the inner layer material supply device 131 is communicated with the inner layer material conveying pipe 6, and is used to convey the inner layer material to the inner layer material conduit 1 through the inner layer material conveying pipe 6;

[0089] The discharge port of the middle-layer material supply device 132 is communicated with the middle-layer material conveying pipe 8, and is used to convey the middle-layer material to the middle-layer material conveying channel 4 through the middle-layer material conveying pipe 8;

[0090] The discharge port of the outer layer material supply device 133 is in communication with the outer layer material conveying pipe 10, and is used to convey the outer layer material to the outer layer material conveying channel 5 through the outer layer material conveying pipe 10;

[0091] The outlet end of the dripper 100 leads to the circulating cooling device 14, and the material dripped from the dripper 100 solidifies in the coolant of the circulating cooling device 14 to form a three-layer drop pill 19, and the drop pill 19 is transported to the pill-liquid separation device 15 along with the circulating coolant to separate the drop pill from the coolant;

[0092] The drying and de-oiling machine 20 is used to dry and de-oil the separated pellets 19 .

[0093] In some embodiments, the inner layer material supply device 131 is provided with an inner layer material constant temperature spacer 16 outside, and the inner layer material constant temperature spacer 16 is connected to the inner layer constant temperature liquid insulation cavity 7;

[0094] The middle-layer material supply device 132 is provided with a middle-layer material constant temperature spacer 17 outside, and the middle-layer material constant temperature spacer 17 is connected with the middle-layer constant temperature liquid insulation cavity 9;

[0095] An outer layer material constant temperature spacer 18 is disposed outside the outer layer material supply device 133 , and the outer layer material constant temperature spacer 18 is communicated with the outer layer constant temperature liquid insulation cavity 11 .

[0096] During the production process, by respectively performing constant temperature control on the interconnected inner layer material constant temperature spacer 16 and inner layer constant temperature liquid insulation cavity 7, the interconnected middle layer material constant temperature spacer 17 and middle layer constant temperature liquid insulation cavity 9, and the interconnected outer layer material constant temperature spacer 18 and outer layer constant temperature liquid insulation cavity 11, the temperatures of the inner layer material, the middle layer material and the outer layer material can be different, and the temperature of each layer of material can be kept constant, thereby improving the stability during the molding of the drop pills, and the circulating cooling device can stabilize the temperature of the coolant during the molding of the drop pills, the cooled and shaped drop pills 19 are separated from the coolant by the pill-liquid separation device 15, the separated coolant re-enters the circulating cooling device for recycling, and the separated drop pills 19 are dried and deoiled by a drying and deoiling machine, thereby producing drop pills 19 with better effects.

[0097] In some embodiments, the dryer and de-oiler 20 includes a sealed box 210 and a drying cage assembly 220. The top of the sealed box 210 is provided with an openable sealed cover 211 to facilitate operation of the interior. One side of the sealed box 210 is provided with an air inlet 212, and three groups of air inlets 212 can be optionally provided to allow dry air (humidity less than 2%) to enter. The other side of the sealed box 210 opposite to the air inlet 212 is provided with an exhaust port 213 to exhaust humid air during gas replacement. The valve of the exhaust port 213 is controlled by a cylinder push rod and can be opened and closed. Closed operation, the drying cage assembly 220 is arranged in the sealed box 210, and the drying cage assembly 220 includes a drying cage 221, a cage driving motor 222, an air collecting box 223 and a fan 224. The drying cage 221 is rotatably connected in the sealed box 210 and driven to rotate by the cage driving motor 222. The air collecting box 223 is arranged below the drying cage 221 and connected to the fan 224. The air collecting box 223 is used to guide the air volume generated by the fan 224 into the drying cage 221. A deoiling cloth is placed in the drying cage 221 for deoiling the pills 19.

[0098] The outer layer of the pill 19 (such as Huanglong pill) uses a water-phase substance, which contains water when it is just produced, and has coolant oil (i.e., oily coolant) on the surface. A dryer must be used to remove the water and the coolant oil on the surface. The dry de-oiling machine 20 provided in this embodiment introduces dry gas through the air inlet 212, and discharges the internal humid air from the exhaust port 213, and continuously replaces it with dry air, so that the relative humidity inside the sealed box 210 can be reduced to 5%. The drying cage 221 inside the sealed box 210 is a cylindrical structure with ventilation holes, wherein the aperture of the ventilation holes is smaller than the particle size of the pills 19. A door panel is provided on the drying cage 221, through which the pills 19 and the degreased cloth can be placed inside the drying cage 221. A fan 224 is provided outside the drying cage 221, and the air outlet of the fan 224 is connected to the air collecting box 223. The air volume is guided to the drying cage 221 through the air collecting box 223 (or air guide plates, air guide pipes and other guide components). The sealed box 210 A frame 225 is fixed inside, and a cage driving motor 222, a drying cage 221, an air collecting box 223 and a fan 224 are all installed on the frame 225. The pellets 19 and the de-oiled cloth are put into the drying cage 221 together. During the rotation of the drying cage 221, the pellets 19 and the de-oiled cloth inside are constantly rolling and swept by the wind, gradually evaporating the moisture on the surface of the pellets 19. During the rolling process, the de-oiled cloth contacts the pellets 19 and gradually absorbs the coolant oil on the surface of the pellets 19, achieving the effect of drying and de-oiling. The drying and de-oiling machine 20 provided in this embodiment creates a low-humidity environment by setting a closed sealed box 210 and introducing dry air, which can improve the drying speed and drying effect.

[0099] The following is a comparative experiment of drying the pills 19 by the drying and de-oiling machine 20 in the embodiment with and without the sealed box 210 .

[0100] As shown in Table 1, there are three common drying processes when the drying and de-oiling machine 20 is not equipped with a sealing box 210. The pellets 19 to be dried are put into the drying cage 221, and the cage drive motor 222 is turned on at an ambient humidity of 45-65% and an ambient temperature of 22°C-26°C. The drying cage 221 rotates at a speed of 5-30RPM, and the fan 224 is turned on to introduce the air in the environment into the drying cage 221 through the air collecting box 223 to dry the pellets 19. The three common processes last for 240 minutes, 360 minutes, and 480 minutes respectively.

[0101] Table 1 Ordinary drying process (without sealed box)

[0102] Total drying time min Ambient humidity % Ambient temperature ℃ Ordinary process 1 240 45-65 22-26 Ordinary Craft 2 360 45-65 22-26 Ordinary process 3 480 45-65 22-26

[0103] As shown in Table 2, the drying improvement process 1 for the drying de-oiling machine 20 with the sealed box 210. The pills 19 to be dried are put into the drying cage 221, the blower 224 is turned on, the cage drive motor 222 is turned on, and the cage drive motor 222 drives the drying cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 50-60% (i.e., dry air is passed when the humidity is higher than 60%, and the humidity is lower than 50% and the dry air is stopped), and it lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is set to be controlled at 40-50% (i.e., dry air is passed when the humidity is higher than 50%, and the humidity is lower than 40% and the dry air is stopped), and it lasts for 30 minutes. By analogy, the drying process of each stage is carried out successively, until the time of each stage is completed. At each stage, the temperature inside the sealed box 210 is controlled to keep the temperature inside the sealed box 210 at 22° C.-26° C. The temperature control relies on a small refrigerator and a PTC heating unit for cooling and heating.

[0104] Table 2 Drying Improvement Process 1 (with sealed box)

[0105] Time min Humidity control% Temperature control℃ Phase 1 60 50-60 22-26 Phase 2 30 40-50 22-26 Phase 3 30 30-40 22-26 Phase 4 30 20-30 22-26 Phase 5 60 10-20 22-26 Total time 210

[0106] As shown in Table 3, the drying improvement process 2 of the drying de-oiling machine 20 with the sealed box 210. The pellets 19 to be dried are put into the drying cage 221, the fan 224 is turned on, the cage drive motor 222 is turned on, and the cage drive motor 222 drives the drying cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 40-50% (i.e., dry air is introduced when the humidity is higher than 50%, and the introduction of dry air is stopped when the humidity is lower than 40%), and it lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is set to be controlled at 30-40% (i.e., dry air is introduced when the humidity is higher than 40%, and the introduction of dry air is stopped when the humidity is lower than 30%), and it lasts for 30 minutes. By analogy, the drying process of each stage is carried out in sequence until the time of each stage is completed. At each stage, the temperature in the sealed box 210 is controlled so that the temperature in the sealed box 210 is maintained at 22°C-26°C.

[0107] Table 3 Drying Improvement Process 2 (with sealed box)

[0108] Time min Humidity control% Temperature control℃ Phase 1 60 40-50 22-26 Phase 2 30 30-40 22-26 Phase 3 30 20-30 22-26 Phase 4 30 10-20 22-26 Phase 5 60 5-10 22-26 Total time 210

[0109] As shown in Table 4, the drying improvement process 3 of the drying de-oiling machine 20 with the sealed box 210. The pellets 19 to be dried are put into the drying cage 221, the fan 224 is turned on, the cage drive motor 222 is turned on, and the cage drive motor 222 drives the drying cage 221 to rotate. In the initial stage 1, the humidity in the sealed box 210 is controlled at 40-50% (i.e., dry air is introduced when the humidity is higher than 50%, and the introduction of dry air is stopped when the humidity is lower than 40%), and it lasts for 60 minutes. After the time is up, the humidity in the sealed box 210 is set to be controlled at 25-35% (i.e., dry air is introduced when the humidity is higher than 35%, and the introduction of dry air is stopped when the humidity is lower than 25%), and it lasts for 60 minutes. By analogy, the drying process of each stage is carried out in sequence until the time of each stage is completed. In each stage, the temperature in the sealed box 210 is controlled so that the temperature in the sealed box 210 is maintained at 22°C-26°C.

[0110] Table 4 Drying Improvement Process 3 (with sealed box)

[0111] Time min Humidity control% Temperature control℃ Phase 1 60 40-50 22-26 Phase 2 60 25-35 22-26 Phase 3 60 10-15 22-26 Phase 4 60 5-10 22-26 Total time 240

[0112] As shown in Table 5, the effects of the ordinary drying process (without a sealed box) and the improved drying process (with a sealed box) are compared.

[0113] Table 5 Comparison of drying effects between ordinary process and improved process

[0114] Total time min Moisture content (%) Water activity Aw Ordinary process 1 240 6.15 0.609 Ordinary Craft 2 360 5.75 0.512 Ordinary process 3 480 4.02 0.463 Improved process 1 210 3.10 0.321 Improved process 2 210 2.61 0.251 Improved process 3 240 1.90 0.180

[0115] According to the effect comparison in Table 5, it can be found that after adding the sealed box 210, the drying time is significantly shortened, and the moisture content and water activity are significantly reduced. With the same drying time (the total drying time of the ordinary process 1 and the improved process 3 is the same), the moisture content of the improved process 3 is reduced by 4.25% and the water activity is reduced by 0.429Aw compared with the ordinary process 1, showing a good effect.

[0116] In some embodiments, the inner material supply device 131 includes an inner material tank 1310, which is fixedly installed in an inner material constant temperature spacer 16, and the inner material constant temperature spacer 16 is placed on an inner material weighing sensor 21. The bottom discharge port of the inner material tank 1310 is connected to an inner material conveying pipe 6, and the inner material conveying pipe 6 is provided with an inner material tank bottom valve 22 and an inner material pump 23;

[0117] The middle-layer material supply device 132 includes a middle-layer material tank 1320, which is fixedly installed in a middle-layer material constant temperature spacer 17, and the middle-layer material constant temperature spacer 17 is placed on a middle-layer material weighing sensor 24. The bottom discharge port of the middle-layer material tank 1320 is connected to a middle-layer material conveying pipe 8, and the middle-layer material conveying pipe 8 is provided with a middle-layer material tank bottom valve 25 and a middle-layer material pump 26;

[0118] The outer material supply device 133 includes an outer material tank 1330, which is fixedly installed in the outer material constant temperature spacer 18, and the bottom discharge port of the outer material tank 1330 is connected to the outer material conveying pipe 10, and the outer material conveying pipe 10 is provided with an outer material tank bottom valve 27 and an outer material pump 28; wherein the rotation speed of the inner material pump 23 is in direct proportion to the feeding speed of the inner material, the rotation speed of the middle material pump 26 is in direct proportion to the feeding speed of the middle material, and the rotation speed of the outer material pump 28 is in direct proportion to the feeding speed of the outer material;

[0119] The inner material tank 1310 and the middle material tank 1320 are both provided with a homogenizing stirring paddle 29, and the homogenizing stirring paddle 29 is provided with a homogenizing stirring sleeve 31 outside. The outer material tank 1330 is provided with a stirring paddle 32, and the homogenizing stirring paddle 29 and the stirring paddle 32 are driven to rotate by a driving motor 30 respectively.

[0120] During the dripping production process, as the inner layer material is continuously transported to the dripper 100 by the inner layer material pump 23, the middle layer material is continuously transported to the dripper 100 by the middle layer material pump 26, the weight of the materials in the inner layer material tank 1310 and the middle layer material tank 1320 decreases, which is detected by the inner layer material weighing sensor 21 and the middle layer material weighing sensor 24 respectively. The controller starts to control the corresponding drive motor 30 to synchronously reduce the speed, which can better maintain the homogeneous state of the material, so that the uniformity of the active ingredients and the uniformity of the particle size of the dripping pills are significantly improved.

[0121] In some embodiments, the homogenizing stirring paddle 29 includes a driving rod 291, a stator 292 and a rotor 293, the output shaft of the driving motor 30 is connected to one end of the driving rod 291, the other end of the driving rod 291 is connected to the rotor 293, and the stator 292 is sleeved outside the rotor 293. The stator 292 is fixed to the corresponding material tank body, or fixed to the support plate of the driving motor 30, and locked with the support plate by a connecting rod and a screw. The rotor 293 is driven to rotate by the driving motor 30 to achieve a homogenizing stirring effect. The stirring paddle 32 can be an ordinary stirring paddle.

[0122] In some embodiments, the pill-liquid separation device 15 includes a pill-liquid separation filter 151 and a coolant recovery tray 152 disposed below the pill-liquid separation filter 151, the circulating cooling device 14 includes a cooling box 141, a coolant circulation pipeline 142, a coolant refrigeration storage box 143 and a refrigeration stirring device 144, the outlet end of the dripper 100 leads to the cooling box 141, one end of the coolant circulation pipeline 142 is connected to the cooling box 141, and the other end leads to the pill-liquid separation filter 151, the coolant outlet of the coolant recovery tray 152 leads to the coolant refrigeration storage box 143, and the pill-liquid separation filter 151 is used to separate the shaped droplets The separated coolant flows into the coolant recovery tray 152, and then flows back from the coolant outlet of the coolant recovery tray 152 to the coolant refrigeration storage tank 143 for recycling. The refrigeration stirring device 144 is connected to the coolant refrigeration storage tank 143, and is used to refrigerate and stir the coolant in the coolant refrigeration storage tank 143. The coolant refrigeration storage tank 143 is connected to the cooling tank 141 through a coolant supply pipe 145. A coolant circulation pump 146 is provided on the coolant supply pipe 145. The coolant in the coolant refrigeration storage tank 143 is pumped into the cooling tank 141 through the coolant circulation pump 146.

[0123] The inner layer material is conveyed to the feed port of the inner layer material conduit 1 of the dripper 100 through the inner layer material conveying pipe 6, the middle layer material is conveyed to the feed port of the middle layer material conveying channel 4 of the dripper 100 through the middle layer material conveying pipe 8, and the outer layer material is conveyed to the feed port of the outer layer material conveying channel 5 of the dripper 100 through the outer layer material conveying pipe 10. Through the guiding effect of the inner layer material conduit 1, the middle layer material conveying channel 4 and the outer layer material conveying channel 5, it finally flows out from the three concentric material outlets at the same time and drips into the coolant below. The material flowing out of the dripper 100, the outermost layer belongs to the water phase material, which is formed into a spherical structure under the action of surface tension in the oil phase liquid of the coolant, and the middle layer and inner layer materials are seamlessly wrapped inside the spherical structure. It is condensed and fixed during the flow in the coolant circulation pipeline 142 to obtain a three-layer pill 19.

[0124] In some embodiments, the refrigeration stirring device 144 includes a coolant stirring device 1440, a cooling coil 1441 and a refrigerator 1442, the cooling coil 1441 is a spiral coil, the cooling coil 1441 is arranged in the coolant refrigeration storage box 143, and the two ports of the cooling coil 1441 are connected to the refrigerator 1442; the coolant stirring device 1440 includes a coolant stirring paddle 14401, a driving connecting rod 14402 and a stirring driving motor 14403, the output shaft of the stirring driving motor 14403 is connected to one end of the driving connecting rod 14402, and the other end of the driving connecting rod 14402 is connected to the coolant stirring paddle 14401, and the coolant stirring paddle 14401 is arranged in the internal space formed by the cooling coil 1441.

[0125] In the pelleting process, the coolant generally uses oily liquid paraffin or dimethyl silicone oil and other food or medicinal processing aids. They are both polymer liquid oils and have the characteristic of increasing viscosity as the temperature decreases. During the refrigeration process, due to the high viscosity and poor fluidity of the coolant, the temperature of the coolant at the bottom of the coolant refrigeration storage box 143 will be low, while the temperature of the coolant at the top will be high. Due to the uneven temperature, the temperature of the pumped coolant (i.e., the coolant entering the cooling box 141) is also unstable, resulting in unstable pelleting effect. In this embodiment, by setting a cooling coil 1441, the refrigerator 1442 continuously sends the refrigerant (chilled water or high-pressure refrigerant) into the inlet of the cooling coil 1441 and withdraws it from the outlet, so as to promote the cooling coil 1441 to cool down, and a coolant stirring paddle 14401 is set in the internal space formed by the winding of the cooling coil 1441. Through the rotation of the coolant stirring paddle 14401, the coolant temperature inside the coolant refrigeration storage box 143 is made uniform, thereby stabilizing the coolant temperature during the pellet forming process and improving the pelleting performance.

[0126] Embodiment 3

[0127] This embodiment provides a method for producing multi-layered drop pills, which is produced using the multi-layered drop pill production system described in Embodiment 2, and includes the following steps:

[0128] Add insulation liquid into the outer material constant temperature spacer 18 and the outer constant temperature liquid insulation cavity 11 and perform constant temperature control, and the constant temperature is 40°C ~ 80°C; add insulation liquid into the middle material constant temperature spacer 17 and the middle constant temperature liquid insulation cavity 9 and perform constant temperature control, and the constant temperature is 35°C ~ 45°C; add insulation liquid into the inner material constant temperature spacer 16 and the inner constant temperature liquid insulation cavity 7 and perform constant temperature control, and the constant temperature is 38°C ~ 43°C; a temperature sensor and a heater are provided in each insulation liquid, and the temperature detected by the temperature sensor is compared with the set temperature, and the PID proportional integral differential control algorithm is adopted to control the output power of the heater to ensure that the temperature of the insulation liquid is stable at the set temperature; turn on the refrigerator 1442, the coolant circulation pump 146 and the stirring drive motor 14403 to control the coolant temperature to be uniform and stable;

[0129] Place the outer layer material into the outer layer material tank 1330, the middle layer material into the middle layer material tank 1320, and the inner layer material into the inner layer material tank 1310;

[0130] After the temperature of each layer of material is balanced, the outer layer material tank bottom valve 27, the outer layer material pump 28, the middle layer material tank bottom valve 25, the middle layer material pump 26, the inner layer material tank bottom valve 22 and the inner layer material pump 23 are opened, and each layer of material is transported to the dripper 100, and flows into the coolant at the same time from the outlet end of the dripper 100;

[0131] In the coolant, the outer layer material is formed into a spherical structure by the surface tension, and the middle layer and inner layer materials are wrapped inside the spherical structure, and then gradually solidified to obtain a three-layer drop pill 19, and then the drop pill 19 and the coolant are separated by a pill-liquid separation filter 151 until the material is exhausted;

[0132] The separated pills 19 and deoiled cloth are arranged in a drying cage 221, and dry air is introduced into the sealed box 210 from the air inlet 212. The cage drive motor 222 and the fan 224 are turned on. During the rotation of the drying cage 221, the pills 19 and deoiled cloth inside are tumbled continuously and swept by the wind at the same time, and the moisture on the surface of the pills 19 is gradually evaporated. During the tumbling process, the deoiled cloth contacts the pills 19 and gradually absorbs the coolant on the surface of the pills 19, thereby achieving drying and deoiling of the pills 19.

[0133] After the outer layer material is placed in the outer layer material tank 1330, the outer layer material tank 1330 is pumped with negative pressure to eliminate bubbles in the outer layer material. The negative pressure pumping time is 10 to 60 minutes until there are no obvious bubbles visually.

[0134] The speed of the outer material pump 28 is adjustable from 5 to 800 RPM, the speed of the middle material pump 26 is adjustable from 5 to 800 RPM, and the speed of the inner material pump 23 is adjustable from 5 to 800 RPM. The refrigeration temperature of the coolant by the refrigerator 1442 is adjustable from 3°C to 25°C, the frequency of the coolant circulation pump 146 is adjustable from 5 to 50HZ, and the homogenization stirring time of the inner material in the inner material tank 1310 is 1 to 30 minutes.

[0135] As shown in Table 6, there are three process embodiments for preparing Huanglong Drop Pills using the multi-layer drop pill production method of this embodiment.

[0136] Table 6 Huanglong dripping pills preparation process

[0137]

[0138]

[0139] The middle layer homogenization stirring speed weight ratio refers to the ratio of the speed of homogenization stirring in the middle layer material tank 1320 to the weight of the remaining material in the tank; the inner layer homogenization stirring speed weight ratio refers to the ratio of the speed of homogenization stirring in the inner layer material tank 1310 to the weight of the remaining material in the tank. The outer layer material temperature, the middle layer material temperature and the inner layer material temperature are kept stable by thermostatically controlling the temperature of the corresponding insulation liquid.

[0140] As shown in Table 7, the pelleting effects of the three processes in Table 6 are compared.

[0141] Table 7 Comparison of the effects of pelleting by drop production process

[0142]

[0143] Among them, the production yield refers to the ratio of qualified pellets obtained through pellet production to the raw materials used in pellet production. The calculation formula is:

[0144]

[0145] Among them: a is the production yield, c is the weight of qualified pills, and b is the weight of the raw materials used in the production of pills; the qualified pills are the finished products after drying and sieving, and the weight of the raw materials used in the production of pills does not include water.

[0146] Particle size uniformity refers to randomly sampling 10 to 100 (n) pellets and measuring the diameter (x i ), and then calculate the relative standard deviation (RSD), the calculation formula is as follows:

[0147]

[0148] Where: S is the standard deviation, is the average value.

[0149] Uniformity of active ingredients: refers to sampling the pellets produced in the early, middle and late stages of production during the production process, testing the bifidobacterium content (CFU) therein, and then calculating the RSD values ​​of the three samples.

[0150] Different process parameters in dripping production will produce different production results. It can be seen from Table 7 that when the feed rate ratio of the outer layer material, the middle layer material, and the inner layer material is 5:3:3 and the coolant temperature is 10°C, the dripping pill production yield and other indicators are better.

[0151] The present invention adopts a dynamic homogenization process in the dripping process. Dynamic homogenization means that the rotation speed of the material homogenization is not fixed, but is adjusted according to the weight of the remaining material in the material tank. The adjustment algorithm is that the rotation speed is proportional to the weight of the remaining material in the tank, that is, as the weight of the material pumped out of the tank decreases, the homogenization speed will also decrease, thereby optimizing the homogenization effect and avoiding excessive homogenization speed when the material is relatively small, which causes the material to be excessively stirred to generate bubbles and temperature increase.

[0152] The present invention adopts a gradient drying method in the process of drying the pills. The so-called gradient drying method mainly refers to that after a sealed box is set, the humidity in the sealed box can be controlled by controlling the introduction of dry gas. In the process of drying the pills, the humidity in the sealed box is set to decrease in a gradient, which is divided into multiple stages, and the humidity in the sealed box is gradually reduced, thereby improving the drying efficiency and saving energy. More importantly, the moisture in the pills can also be evaporated, avoiding the problem of rapid drying causing the surface to be dry while the moisture is still locked inside.

[0153] By adopting the multi-layer dropping pill production system and production method provided by the present invention, three-layer dropping pills (including Huanglong dropping pills) with better effects can be produced, and the production yield, particle size uniformity and active ingredient uniformity of the three-layer dropping pills are improved.

[0154] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only used to help understand the method and core ideas of the present invention. At the same time, for those skilled in the art, according to the ideas of the present invention, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A dripper for preparing multi-layer dripping pills, characterized in that: It comprises an inner material conduit, a middle material conduit and an outer material conduit which are sequentially sleeved on a coaxial line from the inside to the outside; An annular middle-layer material conveying channel is formed between the middle-layer material conduit and the inner-layer material conduit, and an annular outer-layer material conveying channel is formed between the outer-layer material conduit and the middle-layer material conduit; The inlet end of the inner material conduit is connected to the inner material conveying pipe, and the inner material conveying pipe is arranged in the inner constant temperature liquid insulation cavity; The inlet end of the middle-layer material conveying channel is connected to the middle-layer material conveying pipe, and the middle-layer material conveying pipe is arranged in the middle-layer constant temperature liquid insulation cavity; The inlet end of the outer material conveying channel is communicated with the outer material conveying pipe, and the outer material conveying pipe is arranged in the outer constant temperature liquid insulation cavity.

2. The dripper for preparing multi-layered dripping pills according to claim 1, characterized in that: The wall thickness of the outer material conduit is 1.0-6.0 mm, the wall thickness of the middle material conduit is 0.1-1.2 mm, the wall thickness of the inner material conduit is 0.1-1.2 mm, the inner radius r of the inner material conduit is 0.25-5.0 mm, the gap h1 between the middle material conduit and the inner material conduit is 0.2-2.0 mm, the gap h2 between the outer material conduit and the middle material conduit is 0.2-2.0 mm, and the ratio of h2, h1 and r is 1:(0.5-2):(1-4).

3. The dripper for preparing multi-layered dripping pills according to claim 1, characterized in that: The inner edge of the outlet end of the outer material conduit is chamfered.

4. A multi-layered pill production system, characterized in that: It includes material supply device, dripper, circulating cooling device, pill-liquid separation device and drying and deoiling machine; The dripper is a dripper for preparing multi-layered drop pills as described in any one of claims 1 to 3; The material supply device comprises an inner layer material supply device, a middle layer material supply device and an outer layer material supply device; The discharge port of the inner layer material supply device is in communication with the inner layer material conveying pipe, and is used to convey the inner layer material to the inner layer material conduit through the inner layer material conveying pipe; The discharge port of the middle-layer material supply device is in communication with the middle-layer material conveying pipe, and is used to convey the middle-layer material to the middle-layer material conveying channel through the middle-layer material conveying pipe; The discharge port of the outer layer material supply device is in communication with the outer layer material conveying pipe, and is used to convey the outer layer material to the outer layer material conveying channel through the outer layer material conveying pipe; The outlet end of the dripper leads to the circulating cooling device, and the material dripping from the dripper solidifies in the cooling liquid of the circulating cooling device to form three-layer drop pills, and the drop pills are transported to the pill-liquid separation device along with the circulating cooling liquid to separate the drop pills from the cooling liquid; The drying and deoiling machine is used for drying and deoiling the separated dropping pills.

5. The multi-layered pill production system according to claim 4, characterized in that: The inner layer material supply device is provided with an inner layer material constant temperature spacer outside, and the inner layer material constant temperature spacer is connected with the inner layer constant temperature liquid insulation cavity; The middle-layer material supply device is provided with a middle-layer material constant temperature spacer outside, and the middle-layer material constant temperature spacer is connected with the middle-layer constant temperature liquid insulation cavity; The outer layer material supply device is provided with an outer layer material constant temperature isolation jacket outside, and the outer layer material constant temperature isolation jacket is communicated with the outer layer constant temperature liquid insulation cavity.

6. The multi-layered pill production system according to claim 4, characterized in that: The drying and oil-removing machine includes a sealed box body and a drying cage assembly. The top of the sealed box body is provided with an openable sealing cover. One side of the sealed box body is provided with an air inlet for introducing dry air, and the other side is provided with an exhaust port. The drying cage assembly is arranged in the sealed box body. The drying cage assembly includes a drying cage, a cage driving motor, an air collecting box and a fan. The drying cage is rotatably connected in the sealed box body and driven to rotate by the cage driving motor. The air collecting box is arranged under the drying cage and connected to the fan. The air collecting box is used to guide the air generated by the fan into the drying cage. A deoiling cloth is placed in the drying cage for deoiling the pills.

7. The multi-layered pill production system according to claim 5, characterized in that: The inner layer material supply device comprises an inner layer material tank, the inner layer material tank is fixedly installed in the inner layer material constant temperature spacer, the inner layer material constant temperature spacer is placed on the inner layer material weighing sensor, the bottom discharge port of the inner layer material tank is connected to the inner layer material conveying pipe, and the inner layer material conveying pipe is provided with an inner layer material tank bottom valve and an inner layer material pump; The middle-layer material supply device comprises a middle-layer material tank, which is fixedly installed in the middle-layer material constant temperature spacer, and the middle-layer material constant temperature spacer is placed on the middle-layer material weighing sensor. The bottom discharge port of the middle-layer material tank is connected to the middle-layer material conveying pipe, and the middle-layer material conveying pipe is provided with a middle-layer material tank bottom valve and a middle-layer material pump; The outer layer material supply device comprises an outer layer material tank, the outer layer material tank is fixedly installed in the outer layer material constant temperature isolation jacket, the bottom discharge port of the outer layer material tank is connected to the outer layer material conveying pipe, and the outer layer material conveying pipe is provided with an outer layer material tank bottom valve and an outer layer material pump; The inner material tank and the middle material tank are both provided with homogenizing stirring paddles, the homogenizing stirring paddles are provided with homogenizing stirring sleeves outside, the outer material tank is provided with stirring paddles, and the homogenizing stirring paddles and the stirring paddles are respectively driven to rotate by driving motors.

8. The multi-layered pill production system according to claim 4, characterized in that: The pill-liquid separation device includes a pill-liquid separation filter and a coolant recovery tray arranged below the pill-liquid separation filter, the circulating cooling device includes a cooling box, a coolant circulation pipeline, a coolant refrigeration storage box and a refrigeration stirring device, the outlet end of the dripper leads to the cooling box, one end of the coolant circulation pipeline is connected to the cooling box, and the other end leads to the pill-liquid separation filter, the coolant outlet of the coolant recovery tray leads to the coolant refrigeration storage box, the refrigeration stirring device is connected to the coolant refrigeration storage box, and is used to cool and stir the coolant in the coolant refrigeration storage box, the coolant refrigeration storage box is connected to the cooling box through a coolant supply pipeline, and a coolant circulation pump is provided on the coolant supply pipeline.

9. The multi-layered pill production system according to claim 8, characterized in that: The refrigeration stirring device includes a coolant stirring device, a cooling coil and a refrigerator, the cooling coil is arranged in the coolant refrigeration storage box, and the two ports of the cooling coil are connected to the refrigerator; the coolant stirring device includes a coolant stirring paddle, a driving connecting rod and a stirring driving motor, the output shaft of the stirring driving motor is connected to one end of the driving connecting rod, and the other end of the driving connecting rod is connected to the coolant stirring paddle, and the coolant stirring paddle is arranged in the internal space formed by the cooling coil.

10. A method for producing multi-layered dripping pills, characterized in that: The multi-layered pill production system according to any one of claims 4 to 9 comprises the following steps: The outer material constant temperature spacer and the insulating liquid in the outer constant temperature liquid insulation cavity are temperature-controlled, the middle material constant temperature spacer and the insulating liquid in the middle constant temperature liquid insulation cavity are temperature-controlled, and the inner material constant temperature spacer and the insulating liquid in the inner constant temperature liquid insulation cavity are temperature-controlled; Put the outer layer material into the outer layer material tank, the middle layer material into the middle layer material tank, and the inner layer material into the inner layer material tank; The outer layer material in the outer layer material tank, the middle layer material in the middle layer material tank, and the inner layer material in the inner layer material tank are transported to the dripper, and the materials of each layer flow into the coolant simultaneously from the outlet end of the dripper; The outer layer material, the middle layer material and the inner layer material are solidified in the cooling liquid to obtain three-layer pellets, and then the pellets and the cooling liquid are separated by the pellet-liquid separation device; The separated pellets are dried and deoiled by the drying and deoiling machine.

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