PH response release mask and preparation method thereof

Abstract

The invention discloses a pH response release mask and a preparation method thereof, and relates to the technical field of masks. Comprising the following steps: step 1, preparing basic liposome by adopting a film hydration method, and encapsulating functional components in the basic liposome to obtain functional liposome; and step 2, gluing the functional liposome to one side of a mask cloth, and coating the other side of the mask cloth with a hydrophobic layer to obtain the pH response release mask. According to the pH acid response release facial mask, enough essence can be firmly hung on the mask cloth, redundant essence does not need to be left in a package, sufficient wetting of the mask cloth is achieved, meanwhile, the acid response can release component factors at the moment when the facial mask is attached to the skin, the facial mask can be released immediately after being used, the freshness of functional components is kept, and the facial mask is free of side effects. And the transportation pressure is also reduced by the lighter package.

Description

Technical Field

[0001] The invention relates to the technical field of facial masks, and in particular to a pH responsive release facial mask and a preparation method thereof. Background Art

[0002] Traditional facial masks simply cover the essence ingredients on the mask cloth, which may cause leakage during use, and the effective ingredients will inevitably be lost during transportation. At the same time, transportation is also a burden. Therefore, it is necessary to protect the active ingredients so that they can remain active throughout the various commercial processes.

[0003] The pH acid response release mask can firmly hang enough essence on the mask cloth, without leaving excess essence in the package to fully moisten the mask cloth. At the same time, the acid response can release the ingredient factors the moment the mask fits the skin. It can be used and released immediately, maintaining the freshness of the effective ingredients. The lighter packaging also reduces the pressure of transportation.

[0004] Therefore, in order to solve the common problem of inactivation of active ingredients in traditional facial masks on the market and decreased user experience due to dripping, a facial mask that changes the structure of the carrier material according to the pH value of the environment to release active factors is designed, so that the effective ingredients can be released immediately after use, reducing the risk of inactivation of the effective ingredients during transportation. This is an issue that the present invention urgently needs to solve. Summary of the invention

[0005] The present invention provides a pH-responsive release facial mask and a preparation method thereof, which are intended to solve the common problems of inactivation of active ingredients in traditional facial masks and decreased user experience due to dripping in the above-mentioned background technology, fill the gap and improve the freshness of the effective ingredients of the facial mask.

[0006] In order to achieve the above technical objectives, the present invention mainly adopts the following technical solutions:

[0007] The present invention provides a method for preparing a pH-responsive release facial mask, comprising the following steps:

[0008] Step 1, preparing basic liposomes by thin film hydration method, and then encapsulating effective components in the basic liposomes to obtain effective liposomes;

[0009] Step 2: Adhere the functional liposome to one side of the membrane cloth, and coat a hydrophobic layer on the other side of the membrane cloth to obtain the pH-responsive release mask.

[0010] In a preferred embodiment of the present invention, in step 1, the preparation method of the functional liposome is:

[0011] Step 1.1, add hydrogenated soybean lecithin into a glass bottle containing an organic solvent and dissolve it by ultrasonication;

[0012] Step 1.2, removing the organic solvent by rotary evaporation, so that the soy hydrogenated lecithin film adheres to the glass bottle;

[0013] Step 1.3, dissolve the active ingredients in water and add it into the glass bottle with the film attached, then add PBS solution, stir, and sonicate to obtain the active liposome.

[0014] In a preferred embodiment of the present invention, in step 1.1, the organic solvent is chloroform, and 1 mg of the hydrogenated soybean lecithin is added to 0.5-1 ml of chloroform.

[0015] In a preferred embodiment of the present invention, in step 1.2, the rotary evaporation conditions are: at 20-30°C, a vacuum degree of 0.05-0.1 mPa, and a rotation speed of 4-10 rpm, and the rotary evaporation is for 1.5-3 hours.

[0016] In a preferred embodiment of the present invention, in step 1.3, the effective ingredient is selected from ceramide, the pH of the PBS solution is 7.4, and the stirring and ultrasonic conditions are: at 40-60°C, magnetic stirring and hydration for 40-50 minutes, and ultrasonication for 10-20 minutes.

[0017] In a preferred embodiment of the present invention, in step 2, the method of gluing the functional liposomes to the membrane cloth comprises the following steps:

[0018] Step 2.1, preparing a sodium alginate aqueous solution of a set concentration;

[0019] Step 2.2, apply the sodium alginate aqueous solution on the membrane cloth by spin coating; and then add functional liposomes on the membrane cloth on the side coated with the sodium alginate aqueous solution.

[0020] Preferably, in step 2.1, the concentration of the sodium alginate aqueous solution is 25-35 mg / ml.

[0021] In a preferred embodiment of the present invention, in step 2.2, the method of applying the sodium alginate aqueous solution on the membrane cloth is: the membrane cloth is soaked in water and adsorbed on a glass sheet, and the sodium alginate is spread on the membrane cloth by rotation, and the rotation speed is increased to make the sodium alginate layer thinner, and the rotation is stopped, liposomes are added, and then the single layer is spread by rotation.

[0022] In a preferred embodiment of the present invention, in step 2, the hydrophobic layer is a zein aqueous solution.

[0023] The present invention also provides a pH-responsive release facial mask prepared by the above-mentioned preparation method.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. The present invention changes the structure of the functional liposome according to the environmental pH value. The liposome is connected to (2-ethyl-2-oxazoline) or PEOz. The unique tertiary amide structure in the main chain makes PEOz have a pKa close to physiological pH, and the pKa value decreases with the increase of polymerization degree, so it is adjustable. When the environmental pH is lower than pKa, the tertiary amino group in the main chain is protonated, or the carbonyl group in the side chain is oxidized to H + The combined electron transfer makes the N in the chain ionized, inducing the main chain to be positively charged. The increase in charge density changes the chain from hydrophilic to hydrophobic, thus showing pH sensitivity and releasing active factors, making the active ingredients ready for use, reducing the risk of inactivation of the active ingredients during transportation. Liposomes have good targeted delivery and release effects. The use of liposomes in cosmetics has significant effects, is green and non-toxic, easy to obtain, and has good market prospects.

[0026] 2. The pH acid-responsive release mask provided by the present invention can firmly hang sufficient essence on the membrane cloth without leaving excess essence in the package, thereby achieving sufficient moistening of the membrane cloth. At the same time, the acid response can release the ingredient factors at the moment the mask fits the skin, which can be used and released immediately, maintaining the freshness of the effective ingredients. The lighter packaging also reduces the pressure of transportation.

[0027] 3. The release rate of the active ingredients encapsulated by liposomes in this process is much slower at pH = 7.4 than at pH = 5.5. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a preparation process diagram of the functional liposome of the present invention;

[0029] Figure 2 This is a preparation process diagram of the pH-responsive release facial mask of the present invention;

[0030] Figure 3 This is a working principle diagram of the pH response release facial mask of the present invention;

[0031] Figure 4 The figure is a comparison chart of the release rate of the active ingredient encapsulated by the liposome of the present invention under the environmental conditions of pH=7.4 and pH=5.5. DETAILED DESCRIPTION

[0032] The present invention is further described in detail below in conjunction with the examples and drawings, but the embodiments of the present invention are not limited thereto. The raw materials involved in the present invention can be purchased directly from the market. For process parameters not particularly noted, conventional techniques can be used.

[0033] Example 1

[0034] This embodiment adopts the thin film hydration method to prepare liposomes and perform encapsulation and hydrophobic processing, which specifically includes the following steps:

[0035] 1) Preparation of liposomes and encapsulation of ceramide

[0036] Take 4 mg of hydrogenated soybean lecithin and dissolve it in a glass bottle containing 2 ml of chloroform. Ultrasonicate for 10 minutes to completely dissolve the lecithin. Remove the organic solvent by rotary evaporation. Make sure that the organic solvent is completely evaporated and there is no residue in the bottle. Generally, rotary evaporation is used: 25°C, vacuum degree 0.08 mPa, speed 6 rpm, rotary evaporation for 2 hours, so that a film is evenly attached to the glass bottle.

[0037] After ceramide was dissolved in water, it was added to a glass bottle with a film evenly attached, and 2 ml of PBS solution (pH=7.4) was added. The solution was hydrated at 50°C with magnetic stirring for 45 minutes, and ultrasonicated for 15 minutes (30 seconds on and 30 seconds off) to obtain functional liposomes loaded with ceramide.

[0038] 2) Prepare sodium alginate solution and adhere functional liposomes to the membrane cloth

[0039] Take 0.6g of sodium alginate powder, dissolve it in 20ml of deionized water, add a magnetic bar, stir at 1000 rpm for 45 minutes to fully dissolve the sodium alginate, and prepare a sodium alginate solution with a concentration of about 30mg / ml. Use sodium alginate to stick the functional liposomes and the membrane cloth together.

[0040] Use spin coating to wet the membrane cloth and adsorb it on the glass slide. Spin at a low speed to spread the sodium alginate on the membrane cloth. Increase the speed to make the sodium alginate layer as thin as possible. After stopping the rotation, add liposomes to the membrane cloth coated with sodium alginate and spin at a high speed to spread a single layer.

[0041] 3) Applying the hydrophobic layer

[0042] The zein was dissolved in water and then applied to the other side of the membrane cloth to obtain a pH-responsive release mask.

[0043] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A method for preparing a pH-responsive release facial mask, characterized in that: The steps include: Step 1, preparing basic liposomes by thin film hydration method, and then encapsulating effective components in the basic liposomes to obtain effective liposomes; Step 2: Adhere the functional liposome to one side of the membrane cloth, and coat a hydrophobic layer on the other side of the membrane cloth to obtain the pH-responsive release mask.

2. The method for preparing the pH responsive release facial mask according to claim 1, characterized in that: In step 1, the preparation method of the functional liposome is: Step 1.1, add hydrogenated soybean lecithin into a glass bottle containing an organic solvent and dissolve it by ultrasonication; Step 1.2, removing the organic solvent by rotary evaporation, so that the soy hydrogenated lecithin film adheres to the glass bottle; Step 1.3, dissolve the active ingredients in water and add it into the glass bottle with the film attached, then add PBS solution, stir, and sonicate to obtain the active liposome.

3. The method for preparing the pH responsive release facial mask according to claim 2, characterized in that: In step 1.1, the organic solvent is chloroform, and 1 mg of the hydrogenated soybean lecithin is added to 0.5-1 ml of chloroform.

4. The method for preparing the pH responsive release facial mask according to claim 2, characterized in that: In step 1.2, the rotary evaporation conditions are: at 20-30° C., a vacuum degree of 0.05-0.1 mPa, and a rotation speed of 4-10 rpm, and the rotary evaporation is performed for 1.5-3 h.

5. The method for preparing the pH responsive release facial mask according to claim 2, characterized in that: In step 1.3, the effective ingredient is selected from ceramide, the pH of the PBS solution is 7.4, and the stirring and ultrasonic conditions are: at 40-60° C., magnetic stirring and hydration for 40-50 minutes, and ultrasonication for 10-20 minutes.

6. The method for preparing the pH responsive release facial mask according to claim 1, characterized in that: In step 2, the method for adhering the functional liposomes to the membrane cloth comprises the following steps: Step 2.1, preparing a sodium alginate aqueous solution of a set concentration; Step 2.2, apply the sodium alginate aqueous solution on the membrane cloth by spin coating; and then add functional liposomes on the membrane cloth on the side coated with the sodium alginate aqueous solution.

7. The method for preparing the pH responsive release facial mask according to claim 6, characterized in that: In step 2.1, the concentration of the sodium alginate aqueous solution is 25-35 mg / ml.

8. The method for preparing the pH responsive release facial mask according to claim 6, characterized in that: In step 2.2, the method of applying the sodium alginate aqueous solution on the membrane cloth is as follows: the membrane cloth is soaked in water and adsorbed on a glass slide, and the sodium alginate is spread on the membrane cloth by rotation, and the rotation speed is increased to make the sodium alginate layer thinner, and the rotation is stopped, liposomes are added, and then the single layer is spread by rotation.

9. The method for preparing the pH responsive release facial mask according to claim 1, characterized in that: In step 2, the hydrophobic layer is a zein aqueous solution.

10. A pH responsive release facial mask prepared by the preparation method according to any one of claims 1 to 9.

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