Repair type hydrogel mask with high toughness and low bleeding rate and preparation method thereof

Abstract

The invention discloses a repairing type hydrogel mask with high toughness and low bleeding rate and a preparation method of the repairing type hydrogel mask, and belongs to the technical field of cosmetics. The hydrogel mask takes polyvinyl alcohol (PVA) and sodium alginate as matrixes, and is combined with flexibility and moisture retention enhancers such as carbomer, sodium hyaluronate, glycerol and polyethylene glycol (PEG-400) as well as soothing and repairing components such as chamomile extract, centella asiatica extract and small molecular weight fibronectin. By optimizing the formula proportion and the preparation process, the toughness and fitness of the hydrogel mask are remarkably improved, the bleeding rate is reduced, the long-acting moisturizing and repairing effects can be provided, and the hydrogel mask is suitable for various skin types and particularly suitable for sensitive skin.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a repairing hydrogel mask with high toughness and low water separation rate and a preparation method thereof. Background Art

[0002] With the continuous development of cosmetic technology, hydrogels are widely used in the preparation of facial masks due to their excellent moisturizing, film-forming properties and good skin adhesion. In particular, facial masks that provide long-lasting moisturizing and repairing effects have become the focus of skin care product development. Existing hydrogel facial masks mostly use polymer materials such as polyvinyl alcohol (PVA) or sodium alginate as the matrix, and form a gel network structure by cross-linking or thickening. However, traditional hydrogel facial masks have some defects, especially the high water extraction rate, which makes the facial mask unable to maintain a long-term moisturizing effect. In addition, insufficient toughness also affects its fit with the face and reduces the user experience. The hydrogel facial mask in the prior art has a poor feel due to the high water extraction rate and insufficient toughness, especially the inability to lock in moisture for a long time. In addition, the facial mask often separates from the facial skin during long-term wear. On this basis, technicians have developed various improvement measures, but the effect is still unsatisfactory. In order to overcome such defects, providing a hydrogel facial mask with high toughness and low water extraction rate has become an urgent problem to be solved in this field. Summary of the invention

[0003] In order to solve the problems of weak water retention, high water separation rate, insufficient toughness, and inability to fit the skin well in the prior art hydrogel masks, and to repair the damaged skin barrier, the present invention aims to provide a repairing hydrogel mask with high toughness and low water separation rate.

[0004] Another object of the present invention is to provide a method for preparing the above-mentioned high-toughness, low-water separation rate repairing hydrogel mask.

[0005] The purpose of the present invention is achieved through the following scheme: a high-toughness, low-water-separation-rate repairing hydrogel mask, which uses polyvinyl alcohol (PVA) and sodium alginate as a matrix, combines flexibility and moisturizing enhancers such as carbomer, sodium hyaluronate, glycerin and polyethylene glycol (PEG-400), as well as soothing and repairing ingredients chamomile extract, Centella asiatica extract and low-molecular-weight fibronectin, and contains the following components by mass percentage: polyvinyl alcohol 5-15%, sodium alginate 1-5%, carbomer 0.05-1%, sodium hyaluronate 0.1-1%, glycerin 3-10%, PEG-400 2-6%, chamomile extract 0.5-2%, Centella asiatica extract 0.5-2%, fibronectin 1-3%, and the balance is water.

[0006] The present invention also provides a method for preparing a high-toughness, low-water-separation-rate repairing hydrogel facial mask, comprising the following preparation steps: Step 1: Thoroughly disinfect all equipment with 75% ethanol to ensure a clean and sterile operating environment. Weigh each ingredient according to the recipe and prepare sufficient deionized water for subsequent operations; Step 2: Heat deionized water to about 80-90°C, slowly add PVA powder, and stir with a high-speed stirrer (500-800 rpm) for about 1 hour until PVA is completely dissolved to form a transparent and viscous matrix, then cool to 60°C for later use; Step 3: When the temperature drops to 60°C, slowly add the sodium alginate solution prepared in advance and continue stirring for 30 minutes to form a uniform mixed matrix; Step 4: slowly add the carbomer dispersion into the mixture obtained in step 3, and stir until uniformly dispersed to increase the viscosity and thickness of the matrix; Step 5: When the mixture is cooled to below 40°C, add sodium hyaluronate, glycerin, PEG-400, chamomile extract, Centella asiatica extract, and fibronectin of different molecular weights, and stir slowly until completely dissolved; Step: 6: Adjust the pH of the mixed solution obtained in step 5 to 5.0-5.5, cool it to room temperature, pour it into a mold, place it in a freezing environment for freeze molding, then transfer it to room temperature for slow thawing and solidification, and freeze-thaw cycles 3-8 times.

[0007] The mask uses polyvinyl alcohol (PVA) and sodium alginate, combined with the thickening effect of carbomer and sodium hyaluronate, and forms a three-dimensional network structure with high toughness and low water separation rate through multiple freezing cross-linking. The mask has a low water separation rate after long-term wear, thus providing long-lasting moisturizing effect. The mask has excellent toughness and facial fit, suitable for long-term use. The chamomile extract, centella asiatica extract and fibronectin have calming, repairing and anti-inflammatory effects, suitable for sensitive skin.

[0008] The beneficial effects of the present invention are as follows: The hydrogel mask provided by the present invention achieves significant high toughness and low water separation rate characteristics by optimizing the proportion of ingredients and the preparation process, so that the mask can provide a moisturizing effect for a long time. In addition, the added chamomile extract, Centella asiatica extract and low molecular weight fibronectin significantly improve the soothing and repairing effects, and is suitable for use on sensitive skin. The hydrogel mask obtained by the present invention has good adhesion, can be stably attached to the face for a long time, and significantly improves the user experience of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Attached Figure 1 This is a test diagram of the flexibility of the hydrogel repairing facial mask in Example 2; Attached Figure 2 This is a test chart of water retention rate of the hydrogel mask in Example 2; Attached Figure 3 and 4 This is a test diagram of the hydrogel mask fit in Example 2; Attached Figure 5 This is a test chart of the moisture content of the skin stratum corneum in Example 2; Attached Figure 6 This is a test chart of the transepidermal water loss TEWL value of the skin in Example 2. Specific embodiments

[0010] The technical solution of the present invention is further described below through specific embodiments. The present invention is further described without limiting the scope of the present invention.

[0011] Example 1 A high-toughness, low-water-separation repair hydrogel mask is prepared according to the following steps: Step 1: Use 75% ethanol to disinfect tools such as stirrers, molds, and heating equipment, ensure that the work surface is clean and sterile, then weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and keep the temperature constant. Then, turn on the stirrer and adjust the speed to 500-800 rpm, add 35 g of PVA powder, stir while adding to prevent agglomeration, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent and viscous matrix, and cool to 60°C for use; Step 3: Add 35 ml of deionized water to another container, heat it to 60°C, weigh 2 g of sodium alginate, slowly add it into the water, and stir it with a stirrer for 30 minutes until a uniform colloid is formed; then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixed solution is evenly dispersed; Step 4: Add 15 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained above to below 40°C, and sequentially add 0.08% oligomeric sodium hyaluronate (molecular weight 8,000), 0.03% sodium hyaluronate (molecular weight 200,000-400,000), 0.04% sodium hyaluronate (molecular weight 1.3 million), 3% glycerol, 5% PEG-400, 1% chamomile extract, 1% Centella asiatica extract, and 1.5% fibronectin by mass fraction, and slowly stir until completely dissolved; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.5 to ensure the mildness and stability of the mask. After the adjusted mask matrix is ​​cooled to room temperature, pour it into a pre-sterilized mold and place it in a frozen environment (-20°C) for freeze molding for 3 hours, then transfer it to room temperature (25°C) for slow thawing and curing for 1 hour. After that, in order to further enhance the toughness and stability of the mask, repeat the freeze-thaw cycle 3 times, and check the appearance and performance of the mask after each cycle to ensure that it meets the requirements.

[0012] Example 2 A high-toughness, low-water-separation-rate repairing hydrogel mask is prepared according to the following steps: Step 1: Use 75% ethanol to disinfect tools such as stirrers, molds, and heating equipment, ensure that the work surface is clean and sterile, then weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and keep the temperature constant. Then, turn on the stirrer (500-800 rpm), add 40 g of PVA powder, stir while adding to prevent caking, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent and viscous matrix, and cool to 60°C for use; Step 3: Add 40 ml of deionized water to another container, heat it to 60°C, weigh 3 g of sodium alginate, slowly add it to the water, and stir it with a stirrer for 30 minutes until a uniform colloid is formed. Then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixture is evenly dispersed; Step 4: Add 10 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained above to below 40°C, and sequentially add 0.05% oligomeric sodium hyaluronate (molecular weight 8,000), 0.02% sodium hyaluronate (molecular weight 200,000-400,000), 0.03% sodium hyaluronate (molecular weight 1.3 million), 3% glycerol, 5% PEG-400, 1% chamomile extract, 1% Centella asiatica extract, and 1.5% fibronectin by mass fraction, and slowly stir until completely dissolved; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.5 to ensure the mildness and stability of the mask. After the adjusted mask matrix is ​​cooled to room temperature, pour it into a pre-sterilized mold and place it in a frozen environment (-20°C) for freeze molding for 3 hours, then transfer it to room temperature (25°C) for slow thawing and curing for 1 hour. After that, in order to further enhance the toughness and stability of the mask, repeat the freeze-thaw cycle 4 times, and check the appearance and performance of the mask after each cycle to ensure that it meets the requirements.

[0013] Example 3 A high-toughness, low-water-separation repair hydrogel mask is prepared according to the following steps: Step 1: Use 75% ethanol to disinfect tools such as stirrers, molds, and heating equipment, ensure that the work surface is clean and sterile, then weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and keep the temperature constant. Then, turn on the stirrer (500-800 rpm), add 45 g of PVA powder, stir while adding to prevent caking, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent and viscous matrix, and cool to 60°C for use; Step 3: Add 30 ml of deionized water to another container, heat it to 60°C, weigh 2.5 g of sodium alginate, slowly add it to the water, and stir it with a stirrer for 30 minutes until a uniform colloid is formed. Then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixture is evenly dispersed; Step 4: Add 20 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained above to below 40°C, and sequentially add 0.1% oligomeric sodium hyaluronate (molecular weight 8,000), 0.04% sodium hyaluronate (molecular weight 200,000-400,000), 0.03% sodium hyaluronate (molecular weight 1.3 million), 3% glycerol, 5% PEG-400, 1% chamomile extract, 1% Centella asiatica extract, and 1.5% fibronectin by mass fraction, and slowly stir until completely dissolved; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.5 to ensure the mildness and stability of the mask. After the adjusted mask matrix is ​​cooled to room temperature, pour it into a pre-sterilized mold and place it in a frozen environment (-20°C) for freeze molding for 3 hours, then transfer it to room temperature (25°C) for slow thawing and solidification for 1 hour. After that, in order to further enhance the toughness and stability of the mask, repeat the freeze-thaw cycle 5 times, and check the appearance and performance of the mask after each cycle to ensure that it meets the requirements.

[0014] Mask performance test: 1. Toughness test In order to evaluate the physical toughness and structural stability of the hydrogel mask of the embodiment, we conducted tensile tests on the hydrogel mask by twisting and knotting, such as Figure 1The test results show that under such high-intensity pulling and twisting, the mask material can still maintain its structural integrity without any material breakage or separation, proving that it has high physical toughness.

[0015] 2. Water retention test The prepared hydrogel mask was dried at room temperature (25°C) for 1 hour, and the mask weight was weighed every 15 minutes. The water retention rate was calculated as Wr(%)=Wt / W0*100% (W0 and Wt represent the initial mass of the mask and the mass at different intervals, respectively). Figure 2 It can be seen that after being placed at room temperature for one hour, although the water retention rate of the hydrogel mask showed a downward trend with the gradual extension of the drying time, the final water retention rate of the mask still remained at 94.3%, which indicates its excellent moisturizing performance and low water separation rate.

[0016] 3. Skin fit test The fit between the hydrogel mask and the skin was observed by applying the mask to different parts of the hand and under different gestures, and photographed and recorded. Figure 3-4 As shown, the homemade hydrogel did not fall off on either the wrist or the back of the hand, nor did it produce wrinkles or gaps due to changes in gestures, showing excellent fit and adhesion.

[0017] 4. Efficacy test Fifteen volunteers with sensitive skin were selected and asked to use only the hydrogel mask once every two days for 15-20 minutes within two weeks. The stratum corneum water content (Courage+Khazaka skin moisture tester) and the transepidermal water loss TEWL value (Courage+Khazaka skin moisture loss test probe) of the observed parts of the subjects were measured before and after using the sample.

[0018] 5. Evaluation criteria: The larger the measured value of the moisture content of the skin stratum corneum, the higher the moisture content of the skin stratum corneum; The smaller the measured value of transepidermal water loss, the less transepidermal water loss per unit time and per unit cross-sectional area.

[0019] 6. Test results: Depend on Figure 5 It can be seen that after the subjects used the sample for 14 days, the water content of the stratum corneum of the skin increased by 17%, indicating that the test sample has a significant moisturizing effect. Figure 6The test results showed that the TEWL value of the test subjects' skin decreased by 9.7%, indicating that the TEWL of the test sample was significantly reduced after 14 days of use. In summary, the hydrogel mask has obvious repair and moisturizing effects.

Claims

1. A high-toughness, low-water-separation repair hydrogel mask, characterized in that The hydrogel mask uses polyvinyl alcohol (PVA) and sodium alginate as a matrix, and is combined with flexibility and moisturizing enhancers including at least carbomer, sodium hyaluronate, glycerin and polyethylene glycol PEG-400, as well as soothing and repairing ingredients chamomile extract, Centella asiatica extract and low-molecular-weight fibronectin. The hydrogel mask contains the following components by mass percentage: 5-15% polyvinyl alcohol, 1-5% sodium alginate, 0.05-1% carbomer, 0.1-1% sodium hyaluronate, 3-10% glycerin, 2-6% PEG-400, 0.5-2% chamomile extract, 0.5-2% Centella asiatica extract, 1-3% fibronectin, and the balance is water.

2. The high-toughness, low-water-separation repair hydrogel facial mask according to claim 1, characterized in that The molecular weight of the fibronectin is 29 kd.

3. The method for preparing the high-toughness, low-water-separation-rate repairing hydrogel facial mask according to any one of claims 1-2, characterized in that The method comprises the following steps: Step 1: Thoroughly disinfect all equipment with 75% ethanol to ensure a clean and sterile operating environment. Weigh each ingredient according to the recipe and prepare sufficient deionized water for subsequent operations. Step 2: Heat the deionized water to 80-90°C, slowly add PVA powder, stir at high speed until it is completely dissolved to form a transparent viscous liquid, and cool to 60°C for later use. Step 3: When the temperature drops to 60°C, slowly add the sodium alginate solution to the PVA solution obtained in step 2 and continue stirring to form a uniformly dispersed mixed matrix. Step 4: Slowly add the carbomer dispersion into the mixed colloid obtained in step 3, and stir until uniformly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture to below 40°C, add sodium hyaluronate of different molecular weights, glycerin, PEG-400, chamomile extract, Centella asiatica extract, and fibronectin, and stir slowly until completely dissolved; Step 6: Adjust the pH of the mixed solution obtained in step 5 to 5.0-5.5, cool it to room temperature, pour it into a mold, place it in a freezing environment for freeze molding, then transfer it to room temperature for slow thawing and solidification, and perform freeze-thaw cycles 3-8 times.

4. The method for preparing the high-toughness, low-water-separation-rate repairing hydrogel facial mask according to claim 3, characterized in that Said, prepared according to the following steps: Step 1: Use 75% ethanol to disinfect the mixer, mold, and heating equipment tools to ensure that the work surface is clean and sterile. Then, weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and maintain a constant temperature; then, turn on the stirrer and adjust the speed to 500-800 rpm, add 35 g of PVA powder, stir while adding, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent viscous matrix, and cool to 60°C to obtain a PVA solution for use; Step 3: Add 35 ml of deionized water to another container, heat it to 60°C, weigh 2 g of sodium alginate, slowly add it into the water, and stir it with a stirrer for 30 minutes until a uniform colloidal sodium alginate solution is formed; then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixed solution is evenly dispersed to obtain a mixed matrix; Step 4: Add 15 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained in the above step 4 to below 40°C, and sequentially add 0.08% by mass fraction of 8000 molecular weight oligomeric sodium hyaluronate, 0.03% by mass fraction of 200,000-400,000 molecular weight sodium hyaluronate, 0.04% by mass fraction of 1.3 million molecular weight sodium hyaluronate, 3% by mass fraction of glycerol, 5% by mass fraction of PEG-400, 1% by mass fraction of chamomile extract, 1% by mass fraction of Centella asiatica extract, and 1.5% by mass fraction of fibronectin, and slowly stir until completely dissolved to obtain a facial mask matrix; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.

5. After cooling the adjusted mask matrix to room temperature, pour it into a pre-sterilized mold and place it in a -20°C freezing environment for freeze molding for 3 hours. Transfer it to room temperature for slow thawing and solidification for 1 hour. Freeze-thaw cycles are repeated 3 times to obtain a repairing hydrogel mask with high toughness and low water separation rate.

5. The method for preparing the high-toughness, low-water-separation-rate repairing hydrogel facial mask according to claim 3, characterized in that Said, prepared according to the following steps: Step 1: After using 75% ethanol to sterilize the agitator, mold, and heating equipment tools, weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and maintain a constant temperature; then, turn on the stirrer to a speed of 500-800 rpm, add 40 g of PVA powder, stir while adding to prevent caking, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent and viscous matrix, and obtain a PVA solution, which is cooled to 60°C for use; Step 3: Add 40 ml of deionized water to another container, heat it to 60°C, weigh 3 g of sodium alginate, slowly add it into the water, and stir it with a stirrer for 30 minutes until a uniform colloidal sodium alginate solution is formed; then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixed solution is evenly dispersed to obtain a mixed matrix; Step 4: Add 10 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained in the above step 4 to below 40°C, and sequentially add 0.05% by mass fraction of 8000 molecular weight oligomeric sodium hyaluronate, 0.02% by mass fraction of 200,000-400,000 molecular weight sodium hyaluronate, 0.03% by mass fraction of 1.3 million molecular weight sodium hyaluronate, 3% by mass fraction of glycerol, 5% by mass fraction of PEG-400, 1% by mass fraction of chamomile extract, 1% by mass fraction of Centella asiatica extract, and 1.5% by mass fraction of fibronectin, and slowly stir until completely dissolved to obtain a mask matrix; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.

5. After cooling the adjusted mask matrix to room temperature, pour it into a pre-sterilized mold and place it in a -20°C freezing environment for freeze molding for 3 hours, then transfer it to room temperature of 25°C for slow thawing and curing for 1 hour. Freeze-thaw cycles are performed 4 times to obtain a repairing hydrogel mask product with high toughness and low water separation rate.

6. The method for preparing the high-toughness, low-water-separation-rate repairing hydrogel facial mask according to claim 3, characterized in that Said, prepared according to the following steps: Step 1: Use 75% ethanol to disinfect the agitator, mold, and heating equipment tools. After ensuring that the work surface is clean and sterile, weigh the required ingredients according to the recipe and prepare sufficient deionized water; Step 2: Add 450 ml of deionized water to a heat-resistant container, heat to 80-90°C, and maintain a constant temperature; then, turn on the stirrer to a speed of 500-800 rpm, add 45 g of PVA powder, stir while adding to prevent caking, continue stirring and heating for 1 hour, stop heating when the solution is completely dissolved to form a transparent and viscous matrix, and obtain a PVA solution, which is cooled to 60°C for use; Step 3: Add 30 ml of deionized water to another container, heat it to 60°C, weigh 2.5 g of sodium alginate, slowly add it into the water, and stir it with a stirrer for 30 minutes until a uniform colloidal sodium alginate solution is formed; then slowly pour the sodium alginate solution into the PVA solution prepared in step 2, and continue stirring until the mixed solution is evenly dispersed to obtain a mixed matrix; Step 4: Add 20 ml of 2.5% carbomer dispersion, slowly dropwise add it into the mixed matrix obtained in step 3, and stir until evenly dispersed to increase the viscosity and thickness of the matrix; Step 5: Cool the mixture obtained above to below 40°C, and sequentially add 0.1% by mass fraction of 8000 molecular weight oligomeric sodium hyaluronate, 0.04% by mass fraction of 200,000-400,000 molecular weight sodium hyaluronate, 0.03% by mass fraction of 1.3 million molecular weight sodium hyaluronate, 3% by mass fraction of glycerol, 5% by mass fraction of PEG-400, 1% by mass fraction of chamomile extract, 1% by mass fraction of Centella asiatica extract, and 1.5% by mass fraction of fibronectin, and slowly stir until completely dissolved to obtain a mask matrix; Step 6: Adjust the pH value of the mask matrix obtained above to 5.0-5.5, cool the adjusted mask matrix to room temperature, pour it into a pre-sterilized mold and place it in a -20°C freezing environment for freeze molding for 3 hours, then transfer it to 25°C room temperature for slow thawing and solidification for 1 hour; then repeat the freeze-thaw cycle 5 times, check the appearance and performance of the mask after each cycle, and obtain a repairing hydrogel mask product with high toughness and low water separation rate.

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