Intraperitoneal aerosol chemotherapy administration device

Abstract

The invention relates to the technical field of medical equipment, and provides an intraperitoneal aerosol chemotherapy dosing device which comprises a liquid medicine tube, a piston rod is slidably arranged in the middle of the liquid medicine tube, a piston is slidably arranged in the liquid medicine tube, the end of the piston rod and the piston are fixedly installed, and a hose communicated with the liquid medicine tube is arranged at the end, away from the piston rod, of the liquid medicine tube. The intraperitoneal aerosol chemotherapy administration device comprises a hose, an injection tube communicated with the hose is fixedly mounted at the end of the hose, a rotary joint communicated with the injection tube is fixedly mounted at the bottom end of the injection tube, and a vertical tube is rotatably arranged on the rotary joint. The contact area and probability of drugs and dispersive tumor cells are effectively improved, dispersive tumor areas with hidden positions and irregular shapes are included, the limitation of a traditional needle or fixed nozzle drug delivery mode is overcome, comprehensive and deep drug contact is achieved, and the treatment effect is remarkably improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, in particular to an intraperitoneal aerosol chemotherapy drug delivery device. Background Art

[0002] Colorectal cancer is a common malignant tumor of the digestive tract. According to the American Cancer Society's 2020 Global Cancer Statistics Report, its incidence and mortality rate rank third and second respectively worldwide. Metastatic disease is the main cause of death in patients with colorectal cancer, among which peritoneal metastasis (PM) is the second most common metastatic site of colorectal cancer after liver metastasis. According to the statistical report of the National Cancer Center of China, there were approximately 376,300 new cases of colorectal cancer in China in 2015. Studies have shown that approximately 11.2% of colorectal cancer patients have peritoneal metastases. Even with active treatment, most patients with colorectal cancer peritoneal metastases (CPM) still die within 1 year.

[0003] In order to improve the prognosis of patients with peritoneal metastasis, foreign research teams have proposed pressurized intraperitoneal aerosol chemotherapy (PIPAC). As a new way of intraperitoneal administration, PIPAC pressurizes the drug and delivers it into the abdominal cavity in the form of aerosol, allowing the drug to directly contact the peritoneum and act on cancer cells. Currently, researchers in nearly 30 countries have conducted a large number of studies related to PIPAC.

[0004] PIPAC is essentially an intraperitoneal chemotherapy (IPC). IPC is a treatment method that allows drugs to directly interact with cancer cells in the peritoneal cavity, thereby killing cancer cells. Its principles include: the "peritoneum-plasma" barrier can maintain the intraperitoneal drug concentration at a high level for a long time, increase the direct cytotoxicity of chemotherapy drugs to peritoneal metastases, and reduce systemic adverse reactions. When administered intraperitoneally, chemotherapy drugs are absorbed by the mesentery and enter the liver through the portal vein, which can kill tumor cells in the portal vein and metastatic lesions in the liver parenchyma. The first-pass effect in the liver can reduce the amount of chemotherapy drugs entering the systemic circulation, thereby reducing the systemic toxic side effects of the drugs.

[0005] PIPAC is a treatment method based on physical principles to optimize intraperitoneal chemotherapy, mainly including: improving the distribution of drugs in the abdominal cavity in the form of aerosols; increasing intra-abdominal pressure by establishing pneumoperitoneum to counteract the fluid pressure in the tumor tissue space; limiting peritoneal blood circulation during drug administration; and improving drug utilization by controlling environmental parameters in the abdominal cavity. Compared with other chemotherapy methods, PIPAC has the following advantages: good tolerance; few adverse reactions; high drug utilization; can induce histological regression of chemotherapy-resistant peritoneal cancer; laparoscopy can be performed during treatment to evaluate the treatment effect, monitor the degree of disease progression, and guide subsequent treatment

[0006] The Chinese patent application number is: 201922325761.5. A drug administration and pressurizing device for intraperitoneal chemotherapy, a piston rod is arranged inside the transparent syringe, and a pressure relief assembly is arranged on the top of the transparent syringe, a pressurizing assembly is connected to the left side of the transparent syringe, a first connector is connected to the right end of the liquid outlet, a long catheter is fixedly connected to the right end of the first connector, and a second connector is fixedly connected to one end of the long catheter, and the pressurizing assembly is arranged on the left side of the transparent syringe, a pull rod in the assembly is connected to the piston rod, and when the pull rod is pulled toward the arc-shaped support plate, the piston rod can be pushed toward the inside of the transparent syringe, so as to pressurize the medicine liquid inside the syringe, so that the medicine liquid can be injected into the patient's abdominal cavity more quickly, and the pressure relief assembly is arranged on the top of the right end of the transparent syringe, and when the syringe extracts the medicine liquid from the negative pressure vacuum ampoule, the needle is inserted into the ampoule bottle, so that the medicine liquid can be easily extracted from the ampoule bottle.

[0007] However, in the prior art, drug administration through a needle or a fixed nozzle is limited by the distribution range of drug release. Needle administration can usually only deliver drugs in local areas and is difficult to cover the entire abdominal cavity. For diffuse tumors, the drug cannot be widely exposed to all tumor cells, resulting in limited treatment effects. Although fixed nozzles can spray drugs within a certain range, it is also difficult to ensure that the drugs are distributed to every corner of the abdominal cavity, especially for diffuse tumors that are more concealed or irregularly shaped. It is difficult to achieve comprehensive and effective drug contact, thus affecting the treatment effect.

[0008] In summary, the present invention provides an intraperitoneal aerosol chemotherapy drug delivery device to solve the above problems. Summary of the invention

[0009] The purpose of the present invention is to provide an intraperitoneal aerosol chemotherapy drug delivery device to solve the problems raised in the above-mentioned background technology.

[0010] In order to achieve the above-mentioned purpose, the present invention adopts the following technical scheme: an intraperitoneal aerosol chemotherapy drug delivery device, comprising a drug liquid tube, the middle part of which is slidably arranged on a piston rod, a piston is slidably arranged in the drug liquid tube, the end of the piston rod is fixedly installed with the piston, a hose connected to the drug liquid tube is arranged at one end away from the piston rod, an injection tube connected to the drug liquid tube is fixedly installed at the end of the hose, a rotating joint connected to the drug liquid tube is fixedly installed at the bottom end of the injection tube, a vertical tube is rotatably arranged on the rotating joint, a liquid dispensing head connected to the drug liquid tube is fixedly installed at the bottom end of the vertical tube, and the liquid dispensing head side Evenly distributed rotating tubes are arranged while rotating, and the rotating tubes are connected with the liquid dispensing head. Active tubes connected with the active tubes are fixedly installed on the rotating tubes, and nozzles connected with the active tubes are fixedly installed on the bottom ends of the active tubes. A micro cylinder is arranged in the liquid dispensing head, and the end of the micro cylinder output shaft passes through the bottom of the liquid dispensing head, and evenly distributed active rods are rotatably arranged on the end of the micro cylinder output shaft. The number of groups of active rods is the same as the number of groups of active tubes, and the side of the active tube is rotatably arranged near one end of the active tube, and a rotating part for driving multiple groups of nozzles to rotate and spray simultaneously is arranged at the bottom of the injection tube.

[0011] As a further description of the above scheme: by setting up the coordination between the medicine liquid tube, piston rod, piston, hose, injection tube, rotary joint, vertical tube, dispensing head, rotating tube, movable tube, nozzle, micro cylinder, movable rod and rotating parts, it is not only possible to drive multiple groups of nozzles to adjust the angle to spray the medicine, but also possible to drive multiple groups of nozzles to rotate to spray the medicine, so that the medicine can be widely and evenly sprayed on the diffuse tumor, effectively increasing the contact area and probability between the medicine and the diffuse tumor cells, including the diffuse tumor areas with hidden positions and irregular shapes, overcoming the limitations of traditional needle or fixed nozzle drug delivery methods, achieving comprehensive and in-depth drug contact, and significantly improving the treatment effect.

[0012] Preferably, the rotating member includes a mounting box fixedly mounted on the bottom end of the injection tube, a micro motor fixedly mounted in the mounting box, and gear 1 and gear 2 arranged in the mounting box.

[0013] As a further description of the above scheme: the elements within the rotating part are described.

[0014] Preferably, the end of the micromotor output shaft is fixedly mounted on the middle of gear one, the rotary joint is arranged on the top of the installation box, the vertical tube is rotatably arranged on the installation box, the gear two is fixedly mounted on the outer wall of the vertical tube, and the gear one is meshed and transmission-connected with the gear two.

[0015] As a further description of the above scheme: the positional relationship of the components within the rotating part is described.

[0016] Preferably, a sphere is provided on the injection tube, a disc is provided on the outer wall of the sphere, and the sphere is rotatably provided on the disc.

[0017] As a further description of the above scheme: by setting a disc, the injection tube can be limited on the patient's body, and the ball is rotatably set on the disc, so that the angle of the injection tube can be adjusted, and then the spraying direction of the nozzle can be easily adjusted, further improving the applicability of the device.

[0018] Preferably, the ball is slidably arranged on the injection tube, and a damper is arranged between the ball and the injection tube, and a scale is arranged on the outer wall of the injection tube.

[0019] As a further description of the above scheme: a ball sliding on the injection tube can be set to adjust the depth of the nozzle in the patient's body, and a scale is set to facilitate the operator to observe the depth of the nozzle entering the patient's body.

[0020] Preferably, a driving motor is fixedly mounted on the outer wall of the medicine liquid tube, a screw is fixedly mounted on the end of the output shaft of the driving motor, a movable block is threadedly connected to the screw, a connecting rod is fixedly mounted on the movable block, and the end of the connecting rod is fixedly mounted to the outer end of the piston rod.

[0021] As a further description of the above scheme: by setting the cooperation between the driving motor, the screw, the movable block, the connecting rod, the piston rod and the piston, the piston rod and the piston can be electrically driven to achieve automatic injection of the drug, saving time and effort.

[0022] Preferably, the hose is configured as a rubber telescopic tube.

[0023] As a further description of the above solution: the hose is configured as a rubber telescopic tube, so that the hose is not only elastic but also has telescopic functions, thereby improving the flexibility of the injection tube.

[0024] Preferably, a medicine inlet pipe connected to the medicine liquid pipe is fixedly installed on the side thereof, and a one-way valve is provided on the medicine inlet pipe.

[0025] As a further description of the above solution: it is convenient to add medicine into the medicine tube, and the one-way valve can avoid the phenomenon of backflow during the process of drug injection.

[0026] Preferably, a protection box is fixedly installed in the liquid dispensing head, and the micro cylinder is fixedly installed in the protection box.

[0027] As a further description of the above solution: providing a protection box can protect the micro cylinder in the liquid dispensing head and increase the service life of the micro cylinder.

[0028] Preferably, a handle is fixedly mounted on the bottom of the bottom medicine liquid tube, and a controller is provided on the handle. The controller is electrically connected to the micro cylinder, the micro motor, and the drive motor respectively.

[0029] As a further description of the above scheme: a handle is provided to facilitate the operator to hold the medicine liquid tube, and a controller is provided on the handle to facilitate the operator to automatically control various components of the device, thereby improving the convenience of drug administration.

[0030] In summary, compared with the prior art, the present invention has the following beneficial effects:

[0031] 1. The present invention can not only drive multiple groups of nozzles to adjust the angle of spraying drugs, but also drive multiple groups of nozzles to rotate and spray drugs by arranging the coordination between the drug liquid tube, piston rod, piston, hose, injection tube, rotary joint, vertical tube, dispensing head, rotating tube, movable tube, nozzle, micro cylinder, movable rod and rotating parts, so that the drug can be widely and evenly sprayed on diffuse tumors, effectively increasing the contact area and probability between the drug and diffuse tumor cells, including diffuse tumor areas with hidden positions and irregular shapes, overcoming the limitations of traditional needle or fixed nozzle drug administration methods, achieving comprehensive and in-depth drug contact, and significantly improving the treatment effect.

[0032] 2. In the present invention, a disc is provided to limit the position of the injection tube on the patient's body, and a ball sliding on the injection tube can adjust the depth of the nozzle in the patient's body. The ball is rotatably arranged on the disc, so that the angle of the injection tube can be adjusted, and then the spraying direction of the nozzle can be easily adjusted, thereby further improving the applicability of the device.

[0033] 3. In the present invention, by setting the cooperation between the driving motor, the screw rod, the movable block, the connecting rod, the piston rod and the piston, the piston rod and the piston can be electrically driven to realize the automatic injection of the drug, saving time and labor. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 It is a three-dimensional structural diagram of the present invention;

[0035] Figure 2 The piston rod, piston, and connecting rod structure diagram of the present invention;

[0036] Figure 3 The structure diagram of the injection tube, the liquid dispensing head, and the nozzle of the present invention;

[0037] Figure 4 It is a side plan view of the injection tube, the liquid dispensing head, and the nozzle of the present invention;

[0038] Figure 5 It is a bottom view of the structure of the liquid dispensing head and the spray head of the present invention;

[0039] Figure 6 It is a side cross-sectional structural diagram of the liquid dispensing head and the nozzle of the present invention;

[0040] Figure 7 It is a side cross-sectional structural diagram of the installation box of the present invention.

[0041] Legend:

[0042] 1. Medicine liquid tube; 2. Piston rod; 3. Piston; 4. Hose; 5. Injection tube; 6. Rotary joint; 7. Vertical tube; 8. Dispensing head; 9. Rotating tube; 10. Movable tube; 11. Spray nozzle; 12. Micro cylinder; 13. Movable rod; 14. Rotating part; 141. Mounting box; 142. Micro motor; 143. Gear 1; 144. Gear 2; 15. Ball; 16. Disc; 17. Driving motor; 18. Screw; 19. Movable block; 20. Connecting rod; 21. Medicine inlet tube; 22. One-way valve; 23. Handle. DETAILED DESCRIPTION

[0043] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0044] See also Figure 1-7 , the present invention provides a technical solution:

[0045] A device for administering intraperitoneal aerosol chemotherapy comprises a drug liquid tube 1, wherein the middle part of the drug liquid tube 1 is slidably arranged on a piston rod 2, a piston 3 is slidably arranged in the drug liquid tube 1, the end of the piston rod 2 is fixedly installed with the piston 3, the drug liquid tube 1 is provided with a hose 4 connected to the piston rod 2 at one end away from the piston rod 2, an injection tube 5 connected to the hose 4 is fixedly installed at the end, a rotating joint 6 connected to the injection tube 5 is fixedly installed at the bottom end, a vertical tube 7 is rotatably arranged on the rotating joint 6, a liquid dispensing head 8 connected to the vertical tube 7 is fixedly installed at the bottom end, the liquid dispensing head 8 is rotatably arranged with evenly distributed rotating tubes 9, the rotating tubes 9 are connected to the liquid dispensing head 8, movable tubes 10 connected to the movable tubes 10 are fixedly installed on the movable tubes 10, a nozzle 11 connected to the movable tubes 10 is fixedly installed at the bottom end, a micro cylinder 12 is arranged in the liquid dispensing head 8, and the end of the output shaft of the micro cylinder 12 penetrates The bottom of the liquid-penetrating head 8 and the end of the output shaft of the micro-cylinder 12 are rotatably provided with evenly distributed movable rods 13. The number of groups of the movable rods 13 is the same as the number of groups of the movable tubes 10, and the movable rods 13 are rotatably provided on the side of the movable tube 10 near one end of the movable tube 10. The bottom of the injection tube 5 is provided with a rotating member 14 for driving multiple groups of nozzles 11 to rotate and spray simultaneously. The rotating member 14 includes a mounting box 141 fixedly installed at the bottom of the injection tube 5, a micro-motor 142 fixedly installed in the mounting box 141, and a gear 143 and a gear 2 144 arranged in the mounting box 141. The end of the output shaft of the micro-motor 142 is fixedly installed with the middle part of the gear 1 143. The rotary joint 6 is arranged at the top of the mounting box 141. The vertical tube 7 is rotatably arranged on the mounting box 141. The gear 2 144 is fixedly installed on the outer wall of the vertical tube 7. The gear 1 143 is meshed and transmitted with the gear 2 144.

[0046] In the intraperitoneal aerosol chemotherapy drug delivery device, the drug solution is first stored in the drug solution tube 1. When intraperitoneal aerosol chemotherapy drug delivery is required, the medical staff first inserts the spray head 11, the liquid dispensing head 8, and the injection tube 5 into the patient's abdominal cavity, and drives the sliding cooperation of the piston rod 2 and the piston 3 to push the drug solution along the drug solution tube 1 toward the hose 4, and guides the drug solution into the injection tube 5 and the liquid dispensing head 8. The drug solution then enters the rotating tube 9 and the movable rod 13 respectively through the liquid dispensing head 8, and finally sprays the drug on the patient's diffuse tumor through the spray head 11;

[0047] The rotary joint 6 at the bottom end of the injection tube 5 allows the vertical tube 7 to rotate without affecting the liquid supply. The micro motor 142 in the installation box 141 is started, and the output shaft of the micro motor 142 drives the gear 1 143 to rotate. Since the gear 1 143 is meshed and connected with the gear 2 144, and the gear 2 144 is fixedly installed on the outer wall of the vertical tube 7, the vertical tube 7 is driven to rotate, and the liquid separation head 8 at the bottom end of the vertical tube 7 and the rotating tube 9, the movable tube 10 and the nozzle 11 connected to the liquid separation head 8 are also rotated accordingly, and the liquid medicine is rotated and sprayed uniformly; at the same time, when it is necessary to adjust the angle of the nozzle 11 to spray the medicine, the micro cylinder 12 in the liquid separation head 8 is started, and the output shaft of the micro cylinder 12 is extended to push the movable rod 13 to move. Since one end of the movable rod 13 is rotatably connected to the output shaft of the micro cylinder 12, and the other end is rotatably connected to the side of the movable tube 10, the movement of the movable rod 13 drives the movable tube 10 and the nozzle 11 to deflect around the rotating tube 9, so as to adjust the angle of the nozzle 11;

[0048] The intraperitoneal aerosol chemotherapy drug delivery device can not only drive multiple groups of nozzles 11 to adjust the angle of spraying drugs, but also drive multiple groups of nozzles 11 to rotate and spray drugs, so that the drugs can be widely and evenly sprayed on diffuse tumors, effectively increasing the contact area and probability between drugs and diffuse tumor cells, including diffuse tumor areas with hidden locations and irregular shapes, overcoming the limitations of traditional needle or fixed nozzle 11 drug delivery methods, achieving comprehensive and in-depth drug contact, and significantly improving the treatment effect.

[0049] A ball 15 is arranged on the injection tube 5, a disc 16 is arranged on the outer wall of the ball 15, and the ball 15 is rotatably arranged on the disc 16, the ball 15 is slidably arranged on the injection tube 5, and a damper is arranged between the ball 15 and the injection tube 5, and a scale is arranged on the outer wall of the injection tube 5;

[0050] During use, the disc 16 can limit the injection tube 5 on the patient's body. The ball 15 is slidably set on the injection tube 5 and has damping between the injection tube 5. By adjusting the position of the injection tube 5 on the ball 15, the depth of the nozzle 11 in the patient's body can be adjusted. At the same time, the ball 15 is rotatably set on the disc 16. When the operator pushes the injection tube 5 to drive the ball 15 to rotate on the disc 16, the nozzle 11 at the bottom end of the injection tube 5 can be driven to deflect in direction, so that the spraying direction of the nozzle 11 can be easily adjusted, thereby improving the applicability of the device.

[0051] A driving motor 17 is fixedly mounted on the outer wall of the liquid medicine tube 1, a screw rod 18 is fixedly mounted on the end of the output shaft of the driving motor 17, a movable block 19 is threadedly connected to the screw rod 18, a connecting rod 20 is fixedly mounted on the movable block 19, and the end of the connecting rod 20 is fixedly mounted on the outer end of the piston rod 2;

[0052] When drug injection is required, the drive motor 17 fixedly installed on the outer wall of the medicine liquid tube 1 is started, and the output shaft of the drive motor 17 drives the screw rod 18 to rotate. The movable block 19 threadedly connected to the screw rod 18 moves along the screw rod 18 under the rotation of the screw rod 18, and the connecting rod 20 fixedly installed on the movable block 19 drives the piston rod 2 to move. Since the end of the piston rod 2 is fixedly installed with the piston 3 slidably arranged in the medicine liquid tube 1, the piston 3 is pushed to move in the medicine liquid tube 1, so as to realize automatic injection of the drug, saving time and effort.

[0053] The hose 4 is configured as a rubber telescopic tube;

[0054] The hose 4 is configured as a rubber telescopic tube, so that the hose 4 is not only elastic but also has telescopic functions, thereby improving the flexibility of the injection tube 5 .

[0055] A medicine inlet pipe 21 connected to the medicine liquid pipe 1 is fixedly installed on the side thereof, and a one-way valve 22 is arranged on the medicine inlet pipe 21;

[0056] When injecting medicine into the medicine liquid tube 1, the medicine enters the medicine liquid tube 1 through the medicine inlet tube 21 fixedly installed on the side of the medicine liquid tube 1 and connected thereto. A one-way valve 22 is provided on the medicine inlet tube 21 to ensure that the medicine can only flow into the medicine liquid tube 1 in one direction to prevent the medicine from flowing back.

[0057] A protective box is fixedly installed in the liquid dispensing head 8, and the micro cylinder 12 is fixedly installed in the protective box;

[0058] The protection box can protect the micro cylinder 12 in the liquid dispensing head 8 and increase the service life of the micro cylinder 12 .

[0059] A handle 23 is fixedly mounted at the bottom of the bottom medicine tube 1, and a controller is arranged on the handle 23, and the controller is electrically connected to the micro cylinder 12, the micro motor 142, and the drive motor 17 respectively;

[0060] The handle 23 is provided to facilitate the operator to hold the drug solution tube 1, and the controller is provided on the handle 23 to facilitate the operator to automatically control various components of the device, thereby improving the convenience of drug administration.

[0061] Working principle:

[0062] In the intraperitoneal aerosol chemotherapy drug delivery device, the drug solution is first stored in the drug solution tube 1. When intraperitoneal aerosol chemotherapy drug delivery is required, the medical staff first inserts the spray head 11, the liquid dispensing head 8, and the injection tube 5 into the patient's abdominal cavity, and drives the sliding cooperation of the piston rod 2 and the piston 3 to push the drug solution along the drug solution tube 1 toward the hose 4, and guides the drug solution into the injection tube 5 and the liquid dispensing head 8. The drug solution then enters the rotating tube 9 and the movable rod 13 respectively through the liquid dispensing head 8, and finally sprays the drug on the patient's diffuse tumor through the spray head 11;

[0063] The rotary joint 6 at the bottom end of the injection tube 5 allows the vertical tube 7 to rotate without affecting the liquid supply. The micro motor 142 in the installation box 141 is started, and the output shaft of the micro motor 142 drives the gear 1 143 to rotate. Since the gear 1 143 is meshed and connected with the gear 2 144, and the gear 2 144 is fixedly installed on the outer wall of the vertical tube 7, the vertical tube 7 is driven to rotate, and the liquid separation head 8 at the bottom end of the vertical tube 7 and the rotating tube 9, the movable tube 10 and the nozzle 11 connected to the liquid separation head 8 are also rotated accordingly, and the liquid medicine is rotated and sprayed uniformly; at the same time, when it is necessary to adjust the angle of the nozzle 11 to spray the medicine, the micro cylinder 12 in the liquid separation head 8 is started, and the output shaft of the micro cylinder 12 is extended to push the movable rod 13 to move. Since one end of the movable rod 13 is rotatably connected to the output shaft of the micro cylinder 12, and the other end is rotatably connected to the side of the movable tube 10, the movement of the movable rod 13 drives the movable tube 10 and the nozzle 11 to deflect around the rotating tube 9, so as to adjust the angle of the nozzle 11;

[0064] During use, the disc 16 can limit the syringe 5 on the patient's body. The ball 15 is slidably arranged on the syringe 5, and there is damping between the ball 15 and the syringe 5. By adjusting the position of the syringe 5 on the ball 15, the depth of the nozzle 11 in the patient's body can be adjusted. At the same time, the ball 15 is rotatably arranged on the disc 16. When the operator pushes the syringe 5 to drive the ball 15 to rotate on the disc 16, the nozzle 11 at the bottom of the syringe 5 can be driven to deflect in direction, and the spraying direction of the nozzle 11 can be easily adjusted, thereby improving the applicability of the device.

[0065] When injecting medicine, the driving motor 17 fixedly installed on the outer wall of the medicine liquid tube 1 can be started, and the output shaft of the driving motor 17 drives the screw rod 18 to rotate. The movable block 19 threadedly connected to the screw rod 18 moves along the screw rod 18 under the rotation of the screw rod 18, and the connecting rod 20 fixedly installed on the movable block 19 drives the piston rod 2 to move. Since the end of the piston rod 2 is fixedly installed with the piston 3 slidably arranged in the medicine liquid tube 1, the piston 3 is pushed to move in the medicine liquid tube 1, so that the automatic injection of the medicine is realized, which saves time and effort;

[0066] The intraperitoneal aerosol chemotherapy drug delivery device can not only drive multiple groups of nozzles 11 to adjust the angle of spraying drugs, but also drive multiple groups of nozzles 11 to rotate and spray drugs, so that the drugs can be widely and evenly sprayed on diffuse tumors, effectively increasing the contact area and probability between drugs and diffuse tumor cells, including diffuse tumor areas with hidden locations and irregular shapes, overcoming the limitations of traditional needle or fixed nozzle 11 drug delivery methods, achieving comprehensive and in-depth drug contact, and significantly improving the treatment effect.

[0067] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. An intraperitoneal aerosol chemotherapy drug delivery device, comprising a drug liquid tube (1), characterized in that: The middle part of the medicine liquid tube (1) is slidably arranged on the piston rod (2), a piston (3) is slidably arranged in the medicine liquid tube (1), the end of the piston rod (2) is fixedly installed with the piston (3), the medicine liquid tube (1) is provided with a hose (4) connected to the piston rod (2) at one end away from the piston rod (2), an injection tube (5) connected to the injection tube (4) is fixedly installed at the end, a rotating joint (6) connected to the injection tube (5) is fixedly installed at the bottom end, a vertical tube (7) is rotatably arranged on the rotating joint (6), a liquid dispensing head (8) connected to the vertical tube (7) is fixedly installed at the bottom end, and a rotating tube (9) evenly distributed is rotatably arranged on the side of the liquid dispensing head (8), and the rotating tube (9) is connected to the liquid dispensing head (8). The rotating tube (9) is fixedly provided with a movable tube (10) connected thereto, and the bottom end of the movable tube (10) is fixedly provided with a nozzle (11) connected thereto, and a micro cylinder (12) is arranged inside the liquid dispensing head (8), and the end of the output shaft of the micro cylinder (12) passes through the bottom of the liquid dispensing head (8), and the end of the output shaft of the micro cylinder (12) is rotatably provided with evenly distributed movable rods (13), the number of groups of the movable rods (13) is the same as the number of groups of the movable tubes (10), and the movable rods (13) are rotatably provided on the side of the movable tube (10) close to one end of the movable tube (10), and a rotating part (14) for driving multiple groups of nozzles (11) to rotate and spray simultaneously is arranged at the bottom end of the injection tube (5).

2. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: The rotating member (14) comprises a mounting box (141) fixedly mounted on the bottom end of the injection tube (5), a micro motor (142) fixedly mounted in the mounting box (141), and a gear 1 (143) and a gear 2 (144) arranged in the mounting box (141).

3. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 2, characterized in that: The end of the output shaft of the micro motor (142) is fixedly mounted on the middle of the gear 1 (143), the rotary joint (6) is arranged on the top of the installation box (141), the vertical tube (7) is rotatably arranged on the installation box (141), the gear 2 (144) is fixedly mounted on the outer wall of the vertical tube (7), and the gear 1 (143) is meshed and transmission-connected with the gear 2 (144).

4. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: A sphere (15) is arranged on the injection tube (5), a disc (16) is arranged on the outer wall of the sphere (15), and the sphere (15) is rotatably arranged on the disc (16).

5. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 4, characterized in that: The spherical ball (15) is slidably arranged on the injection tube (5), and a damper is arranged between the spherical ball (15) and the injection tube (5), and the outer wall of the injection tube (5) is provided with a scale.

6. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: A driving motor (17) is fixedly mounted on the outer wall of the drug liquid tube (1), a screw rod (18) is fixedly mounted on the end of the output shaft of the driving motor (17), a movable block (19) is threadedly connected to the screw rod (18), a connecting rod (20) is fixedly mounted on the movable block (19), and the end of the connecting rod (20) is fixedly mounted on the outer end of the piston rod (2).

7. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: The hose (4) is configured as a rubber telescopic tube.

8. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: A medicine inlet pipe (21) connected to the medicine liquid pipe (1) is fixedly installed on the side thereof, and a one-way valve (22) is arranged on the medicine inlet pipe (21).

9. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: A protection box is fixedly installed in the liquid dispensing head (8), and the micro cylinder (12) is fixedly installed in the protection box.

10. The intraperitoneal aerosol chemotherapy drug delivery device according to claim 1, characterized in that: A handle (23) is fixedly mounted on the bottom of the bottom medicine liquid tube (1), and a controller is arranged on the handle (23). The controller is electrically connected to the micro cylinder (12), the micro motor (142), and the drive motor (17) respectively.

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