Traditional Chinese medicine composition for maintaining and conditioning intestines and stomach as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for maintaining and conditioning intestines and stomach. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 4-8 parts of a traditional Chinese medicine extract A, 2-8 parts of a traditional Chinese medicine extract B, 4-6 parts of a traditional Chinese medicine extract C and 6-12 parts of a traditional Chinese medicine extract D. According to the traditional Chinese medicine composition, coix seeds, almonds, Chinese yams, lotus seeds, gordon euryale seeds and hericium erinaceus are used as a formula, the components are extracted, separated, enriched and purified through different methods to obtain extracts of different components, the extracts are reasonably proportioned, and the prepared traditional Chinese medicine composition can obviously relieve hyperacidity and abnormal intestinal peristalsis (too fast or too slow), and has the effects of improving the immunity and improving the immunity. Therefore, acute and chronic gastroenteritis reactions such as abdominal distension, diarrhea and constipation are caused, and the effects of maintaining and conditioning the stomach and the intestine are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for gastrointestinal care and conditioning, and a preparation method and application thereof. Background Art

[0002] Bazhenfen is a Chinese medicine prescription. It has the effect of nourishing the spleen and stomach, replenishing qi and strengthening the middle. It is mainly used to treat weak spleen and stomach, indigestion, reduced appetite, yellow face and fatigue. It is composed of lotus seeds, raw white atractylodes, poria, Euryale ferox, yam, coix seed, lentil and codonopsis.

[0003] The disadvantages of the prior art are that the process is relatively backward and the dosage is large. Therefore, it is very necessary to provide a Chinese medicine composition that has obvious anti-inflammatory, stomach pain relief, defecation improvement, and stomach function improvement effects while having a small dosage. Summary of the invention

[0004] In view of this, the technical problem to be solved by the present invention is to provide a Chinese medicine composition. The gastrointestinal care and conditioning composition provided by the present invention has the effects of anti-inflammatory, relieving stomach pain, improving defecation and / or improving gastric function.

[0005] The present invention provides a traditional Chinese medicine composition for gastrointestinal care and conditioning, characterized in that it comprises the following raw materials in parts by weight:

[0006] 4-8 parts of Chinese herbal medicine extract A, 2-8 parts of Chinese herbal medicine extract B, 4-6 parts of Chinese herbal medicine extract C, and 6-12 parts of Chinese herbal medicine extract D;

[0007] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0008] 4 parts of Chinese herbal medicine extract A, 2 parts of Chinese herbal medicine extract B, 4 parts of Chinese herbal medicine extract C, and 6 parts of Chinese herbal medicine extract D.

[0009] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0010] 4 parts of Chinese herbal medicine extract A, 5 parts of Chinese herbal medicine extract B, 5 parts of Chinese herbal medicine extract C, and 9 parts of Chinese herbal medicine extract D.

[0011] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0012] 4 parts of Chinese herbal medicine extract A, 8 parts of Chinese herbal medicine extract B, 6 parts of Chinese herbal medicine extract C, and 12 parts of Chinese herbal medicine extract D.

[0013] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0014] 6 parts of Chinese herbal medicine extract A, 2 parts of Chinese herbal medicine extract B, 5 parts of Chinese herbal medicine extract C, and 12 parts of Chinese herbal medicine extract D.

[0015] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0016] 6 parts of Chinese herbal medicine extract A, 5 parts of Chinese herbal medicine extract B, 6 parts of Chinese herbal medicine extract C, and 6 parts of Chinese herbal medicine extract D.

[0017] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0018] 6 parts of Chinese herbal medicine extract A, 8 parts of Chinese herbal medicine extract B, 4 parts of Chinese herbal medicine extract C, and 9 parts of Chinese herbal medicine extract D.

[0019] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0020] 8 parts of Chinese herbal medicine extract A, 2 parts of Chinese herbal medicine extract B, 6 parts of Chinese herbal medicine extract C, and 9 parts of Chinese herbal medicine extract D.

[0021] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0022] 8 parts of Chinese herbal medicine extract A, 5 parts of Chinese herbal medicine extract B, 4 parts of Chinese herbal medicine extract C, and 12 parts of Chinese herbal medicine extract D.

[0023] In one preferred embodiment of the present invention, the Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight:

[0024] 8 parts of Chinese herbal medicine extract A, 8 parts of Chinese herbal medicine extract B, 5 parts of Chinese herbal medicine extract C, and 6 parts of Chinese herbal medicine extract D.

[0025] According to the present invention, the preparation method of the Chinese medicine extract A comprises: squeezing coix seeds and almonds to obtain oil and mixed powder after squeezing; freeze-drying the oil to obtain freeze-dried powder; mixing the mixed powder after squeezing and the freeze-dried powder to obtain the Chinese medicine extract A;

[0026] Preferably, the preparation method of the Chinese medicine extract A comprises:

[0027] S1) crushing coix seeds and almonds, drying, pressing oil, filtering, and obtaining oil and pressed mixed powder; the mass ratio of coix seeds to almonds is 10:15; the drying is performed at 50° C. for 4 hours; the filtering is performed by filtering through a 400-mesh filter cloth;

[0028] S2) freeze-drying the oil to obtain freeze-dried powder; the freeze-drying parameters include:

[0029] The freeze-drying curve is: pre-freezing stage 0 to 6 hours, freezing temperature is -40 to -45°C; sublimation drying stage, A: 7 to 10 hours, freezing temperature is -10 to -12°C; B: 10 to 30 hours, freezing temperature is -5 to 0°C; C: 30 to 40 hours, freezing temperature is 15 to 20°C; analytical drying 40 to 50 hours, temperature is 25 to 30°C.

[0030] S3) drying the squeezed mixed powder and mixing it with the freeze-dried powder to obtain the Chinese medicine extract A; the drying is performed at 70° C. for 8 hours.

[0031] The preparation method of the Chinese medicine extract A of the present invention comprises the following steps: firstly, crushing coix seeds and almonds; drying at 50°C for 4 hours, placing the crushed coix seeds and almonds in an XZ-Z600 type cold press, pressing the crushed coix seeds at a fourth gear speed, removing impurities through a 400-mesh filter cloth, and obtaining oil and mixed powder after pressing.

[0032] The oil is freeze-dried to obtain freeze-dried powder; the freeze-drying parameters include: a pre-freezing stage of 0 to 6 hours, a freezing temperature of -40 to -45°C; a sublimation drying stage, A: 7 to 10 hours, a freezing temperature of -10 to -12°C; B: 10 to 30 hours, a freezing temperature of -5 to 0°C; C: 30 to 40 hours, a freezing temperature of 15 to 20°C; and analytical drying for 40 to 50 hours at a temperature of 25 to 30°C.

[0033] The squeezed mixed powder is dried and then mixed with the freeze-dried powder to obtain the Chinese medicine extract A; the drying step is drying at 70° C. for 8 hours.

[0034] The preparation method of the Chinese medicine extract B comprises: extracting yam and lotus seeds with water to obtain an extract, namely the Chinese medicine extract B. More preferably, yam and lotus seeds are extracted twice with 10 times the amount of water, each time for 1 hour, the decoctions are combined, filtered, and concentrated to an extract with a relative density of 1.05 to 1.10.

[0035] According to the present invention, the mass ratio of yam to lotus seeds is 8:4; the solid-liquid ratio of water extraction is 1:10-20; and the relative density of the extract is 1.05-1.10.

[0036] The preparation method of the traditional Chinese medicine extract C of the invention comprises: extracting coix seeds, euryale seeds and almonds by steam distillation, collecting volatile oil, and freeze-drying to obtain the extract.

[0037] The mass ratio of coix seeds, euryale seeds and apricot kernels is 7:10:7; the solid-liquid ratio of steam distillation extraction is 1:10; the soaking time is 1 hour; and the steam distillation extraction time is 6 hours.

[0038] The freeze-drying parameters of the present invention include: a pre-freezing stage of 0 to 6 hours, a freezing temperature of -40 to -45°C; a sublimation drying stage, A: 7 to 10 hours, a freezing temperature of -10 to -12°C; B: 10 to 30 hours, a freezing temperature of -5 to 0°C; C: 30 to 40 hours, a freezing temperature of 15 to 20°C; and analytical drying for 40 to 50 hours at a temperature of 25 to 30°C.

[0039] The preparation method of the traditional Chinese medicine extract D comprises: extracting Hericium erinaceus with water and drying the extract.

[0040] According to the present invention, the preparation method of the Chinese medicine extract D comprises: soaking Hericium erinaceus in water, extracting, and drying to obtain Hericium erinaceus. Soaking Hericium erinaceus in water, extracting with water, combining the decoctions, concentrating, and spray drying to obtain Hericium erinaceus.

[0041] Specifically, the mass ratio of Hericium erinaceus to water is 1:10; the soaking time is 1 hour; the number of extractions is 2 times; and the extraction time is 1 hour.

[0042] The present invention also provides a method for preparing the Chinese medicine composition for gastrointestinal care and conditioning according to any one of the above technical solutions, comprising the following steps:

[0043] The Chinese herbal medicine extract A, the Chinese herbal medicine extract B, the Chinese herbal medicine extract C and the Chinese herbal medicine extract D are mixed to obtain the product.

[0044] The present invention has clearly described the above-mentioned Chinese herbal extract A, Chinese herbal extract B, Chinese herbal extract C and Chinese herbal extract D, which will not be repeated here. The present invention does not limit the specific mixing method, which is well known to those skilled in the art.

[0045] The present invention also provides the use of any of the above-mentioned compositions or compositions prepared by any of the above-mentioned preparation methods in the preparation of products for treating gastrointestinal health care and conditioning.

[0046] The gastrointestinal care and conditioning of the present invention includes anti-inflammation, relieving stomach pain, improving bowel movements and / or improving gastric function.

[0047] Among them, anti-inflammatory effects include reduced ear swelling, increased ear swelling inhibition rate, and reduced TNF-α and IL-6 levels.

[0048] Improving bowel movements includes: increasing the propulsion rate of the small intestine.

[0049] Improving gastric function includes: lowering gastric acid pH, and significantly increasing the levels of pepsin and gastrin.

[0050] The present invention also provides a gastrointestinal care and conditioning medicine, comprising any one of the above-mentioned compositions or a composition prepared by the above-mentioned preparation method.

[0051] The medicine of the present invention also includes excipients commonly used in the pharmaceutical field. The dosage form of the present invention includes but is not limited to tablets, powders, granules, pills, etc.

[0052] The Chinese medicine prescription provided by the present invention is organized into a prescription under the guidance of traditional Chinese medicine theory through dialectical argumentation and according to the needs of the disease, and the clinical efficacy is improved through the compatibility. The prescription uses yam and lotus seed water extract as the main ingredients, which can invigorate the spleen and stomach, nourish the kidney and benefit the essence, and replenish the spleen. The hericium erinaceus water extract is used as the minister, which can invigorate the stomach and harmonize the middle, benefit the five internal organs, aid digestion, benefit the positive energy, and replenish the deficiency. Coix seed and almond oil; coix seed, Euryale ferox, and almond volatile oil are used as the messenger, which can promote the upper-jiao lung qi, moisten the intestines and relieve constipation, and consolidate the lower-jiao kidney qi, and promote water and moisture. All the medicines are used together to play the effect of invigorating the spleen and stomach.

[0053] The beneficial effects of the present invention are: the Chinese medicine composition of the present invention has obvious anti-inflammatory, stomach pain relief, defecation improvement, and gastric function improvement effects, and compared with the Chinese medicine positive drug group, the effect is equivalent, and under the same dosage condition, it is better than the food group (P<0.05), and better than other Chinese medicine composition groups. It shows that the Chinese medicine composition of the present invention can significantly relieve hyperacidity and abnormal intestinal peristalsis (too fast or too slow), thereby causing acute and chronic gastroenteritis reactions such as abdominal distension, diarrhea, and constipation, thereby achieving the effect of gastrointestinal care and conditioning. DETAILED DESCRIPTION

[0054] The present invention provides a Chinese medicine composition for gastrointestinal care and conditioning, and a preparation method and application thereof. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve it. It should be particularly pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they all fall within the scope of protection of the present invention. The methods and applications of the present invention have been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications of this article without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0055] It should be understood that in the various embodiments of the present application, the size of the serial numbers of the above-mentioned processes does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0056] The numerical ranges and parameters involved in the present invention have presented the relevant numerical values ​​in the specific embodiments as accurately as possible. However, any numerical value essentially inevitably contains standard deviations due to individual testing methods. Therefore, unless otherwise explicitly stated, it should be understood that all numerical ranges or specific data used in this disclosure may have certain reasonable deviations within a certain range, for example: within 1% or 0.5%.

[0057] Some cases are recorded in the embodiments and comparative examples of the present invention, wherein the embodiments show certain implementation modes of the present invention. However, this does not mean that the effects of the present invention can only be achieved in these cases.

[0058] To further illustrate the present invention, a Chinese medicine composition for gastrointestinal care and conditioning provided by the present invention, as well as a preparation method and application thereof are described in detail below in conjunction with examples.

[0059] Embodiment 1:

[0060] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0061] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0062] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0063] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0064] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0065] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0066] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0067] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0068] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated, as shown in Tables 1 and 2.

[0069] Embodiment 2:

[0070] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0071] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0072] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0073] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0074] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0075] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0076] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0077] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0078] 4 parts of a Chinese herbal extract A with gastrointestinal care and conditioning

[0079] 5 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0080] 5 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0081] A Chinese medicine extract D with gastrointestinal care and conditioning 9 parts

[0082] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0083] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0084] Embodiment 3:

[0085] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0086] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0087] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0088] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0089] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0090] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0091] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0092] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0093] 4 parts of a Chinese herbal extract A with gastrointestinal care and conditioning

[0094] 8 portions of Chinese herbal extract B with gastrointestinal care and conditioning

[0095] A Chinese herbal extract C with gastrointestinal care and conditioning 6 parts

[0096] A Chinese herbal extract D with gastrointestinal care and conditioning 12 parts

[0097] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0098] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0099] Embodiment 4:

[0100] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0101] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0102] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0103] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0104] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0105] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0106] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0107] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0108] A Chinese herbal extract with gastrointestinal care and conditioning A 6 parts

[0109] 2 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0110] 5 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0111] A Chinese herbal extract D with gastrointestinal care and conditioning 12 parts

[0112] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0113] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0114] Embodiment 5:

[0115] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0116] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0117] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0118] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0119] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0120] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0121] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0122] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0123] A Chinese herbal extract with gastrointestinal care and conditioning A 6 parts

[0124] 5 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0125] A Chinese herbal extract C with gastrointestinal care and conditioning 6 parts

[0126] A Chinese herbal extract D with gastrointestinal care and conditioning 6 parts

[0127] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0128] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0129] Embodiment 6:

[0130] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0131] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0132] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0133] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0134] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0135] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0136] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0137] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0138] A Chinese herbal extract with gastrointestinal care and conditioning A 6 parts

[0139] 8 portions of Chinese herbal extract B with gastrointestinal care and conditioning

[0140] 4 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0141] A Chinese medicine extract D with gastrointestinal care and conditioning 9 parts

[0142] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0143] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0144] Embodiment 7:

[0145] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0146] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0147] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0148] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0149] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0150] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0151] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0152] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0153] 8 portions of Chinese herbal extract A with gastrointestinal care and conditioning

[0154] 2 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0155] A Chinese herbal extract C with gastrointestinal care and conditioning 6 parts

[0156] A Chinese medicine extract D with gastrointestinal care and conditioning 9 parts

[0157] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0158] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0159] Embodiment 8:

[0160] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0161] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0162] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0163] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0164] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0165] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0166] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0167] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0168] 8 portions of Chinese herbal extract A with gastrointestinal care and conditioning

[0169] 5 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0170] 4 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0171] A Chinese herbal extract D with gastrointestinal care and conditioning 12 parts

[0172] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0173] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Tables 1 and 2.

[0174] Embodiment 9:

[0175] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0176] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0177] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0178] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0179] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0180] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0181] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0182] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0183] 8 portions of Chinese herbal extract A with gastrointestinal care and conditioning

[0184] 8 portions of Chinese herbal extract B with gastrointestinal care and conditioning

[0185] 5 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0186] A Chinese herbal extract D with gastrointestinal care and conditioning 6 parts

[0187] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0188] Take a Chinese herbal extract A, a Chinese herbal extract B, a Chinese herbal extract C, and a Chinese herbal extract D that have gastrointestinal care and conditioning, take the number of A, B, C, and D as factors, and determine three levels for each factor to design an orthogonal test table 1. Mix the Chinese herbal extracts according to the proportions of the above embodiments 1 to 9, and prepare nine groups of extracts, Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅵ, Ⅶ, Ⅷ, and Ⅸ, in sequence for pharmacodynamic research, comprehensively evaluate their gastrointestinal care and conditioning effects, and screen out the best group of extracts.

[0189] 4 parts of a Chinese herbal extract A with gastrointestinal care and conditioning

[0190] 2 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0191] 4 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0192] A Chinese herbal extract D with gastrointestinal care and conditioning 6 parts

[0193] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0194] Table 1

[0195]

[0196]

[0197] Table 2

[0198]

[0199] Table 3

[0200]

[0201] Comparative Example 1:

[0202] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0203] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0204] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0205] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0206] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0207] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0208] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0209] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0210] A Chinese herbal extract with gastrointestinal care and conditioning A 2 parts

[0211] 9 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0212] 4 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0213] A Chinese herbal extract D with gastrointestinal care and conditioning 12 parts

[0214] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0215] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Table 3.

[0216] Comparative Example 2:

[0217] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0218] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0219] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0220] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0221] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0222] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0223] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0224] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0225] A Chinese herbal extract with gastrointestinal care and conditioning A 6 parts

[0226] 2 parts of Chinese herbal extract B with gastrointestinal care and conditioning

[0227] 7 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0228] 4 parts of a Chinese herbal extract D with gastrointestinal care and conditioning

[0229] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0230] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Table 3.

[0231] Comparative Example 3:

[0232] A Chinese herbal extract A with gastrointestinal care and conditioning effects:

[0233] Take 10 parts of coix seeds and 15 parts of almonds, grind them into fine powder, dry them at 50°C for 4 hours, put them into XZ-Z600 cold press, press them at four gears, pass through 400 mesh filter cloth to remove impurities, obtain mixed oil, freeze-dry and set aside. Dry the pressed mixed powder at 70°C for 8 hours and mix it evenly with the freeze-dried powder, to obtain a Chinese medicine extract A with gastrointestinal care and conditioning.

[0234] A Chinese herbal extract B with gastrointestinal care and conditioning effects:

[0235] Take 8 parts of yam and 4 parts of lotus seeds, add 10 times the amount of water, extract twice, each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.05-1.10, and freeze-dry to obtain a Chinese medicine extract B with gastrointestinal care and conditioning.

[0236] A Chinese herbal extract C with gastrointestinal care and conditioning effects:

[0237] Take 7 parts of coix seeds, 10 parts of Euryale ferox and 7 parts of almonds, grind them into fine powder, add 10 times the amount of water and soak them for 1 hour, use steam distillation to extract volatile oil for 6 hours, collect the volatile oil, freeze-dry, and obtain a Chinese medicine extract C with gastrointestinal care and conditioning.

[0238] A Chinese herbal extract D with gastrointestinal care and conditioning effects:

[0239] Take 15 parts of Hericium erinaceus, soak for 1 hour, add 10 times the amount of water to extract twice, each time for 1 hour, combine the decoctions, concentrate to 10 parts of Hericium erinaceus medicinal materials per liter of solution, spray dry, and obtain a Chinese medicine extract D with gastrointestinal care and conditioning.

[0240] 5 parts of a Chinese herbal extract with gastrointestinal care and conditioning

[0241] 10 portions of Chinese herbal extract B with gastrointestinal care and conditioning

[0242] 7 parts of Chinese herbal extract C with gastrointestinal care and conditioning

[0243] 8 portions of Chinese herbal extract D with gastrointestinal care and conditioning

[0244] Mix evenly according to the above proportions, add appropriate amount of lactose, and make 1000 tablets.

[0245] The Chinese herbal extracts were mixed according to the above ratios and their gastrointestinal conditioning effects were evaluated. See Table 3.

[0246] E. Comparative experimental study on the pharmacodynamics of the extracts of the present invention and the comparative examples

[0247] Gastrointestinal discomfort may be related to a variety of lifestyles: 1. Irregular diet: Eating at irregular times and in irregular quantities may cause hunger or overfullness in the intestines, thereby interfering with the normal movement of the intestines and increasing the gastrointestinal burden in the long run. 2. Eating too fast: Eating quickly may lead to inadequate chewing of food, affecting the mixing of digestive juices and food, leading to indigestion and damage to the intestines. 3. Unhygienic diet: Intake of unhygienic food may cause intestinal infection, produce toxins, and trigger gastrointestinal diseases such as acute gastroenteritis. 4. Too greasy diet: A high-fat diet may be difficult to digest, change the balance of intestinal flora, and is not conducive to the survival of beneficial bacteria. Long-term intake of too much greasy food may lead to depletion of digestive enzymes. 5. Insufficient water and fiber intake: This may cause constipation and increase the risk of colon cancer.

[0248] These bad habits may cause physiological problems including excessive stomach acid and abnormal intestinal motility (too fast or too slow), which can lead to acute and chronic gastroenteritis such as bloating, diarrhea, and constipation. During acute and chronic gastroenteritis, proinflammatory cytokines (such as IL-6 and TNF-α) are released, leading to decreased levels of pepsin and gastrin. Pepsin and gastrin are key indicators for evaluating gastric function, and changes in their levels can reflect the health of gastric function. Therefore, monitoring these indicators is crucial for diagnosis and treatment of gastrointestinal discomfort and related diseases.

[0249] Gastrointestinal care and conditioning are essential for maintaining overall health. A healthy digestive system not only ensures that the body absorbs nutrients effectively and supports the normal functioning of various body functions, but also helps eliminate waste and toxins, prevent constipation and gastrointestinal diseases. In addition, good gastrointestinal health is closely related to the strength of the immune system, which helps to resist disease and infection. With the accelerated pace of modern life, irregular eating habits, high stress and unhealthy dietary choices often put a burden on the stomach and intestines. Therefore, taking appropriate maintenance measures is significantly necessary to promote gastrointestinal health and prevent related diseases, enhance gastrointestinal function, reduce inflammation, and maintain the balance of intestinal flora, thereby improving the quality of life and reducing the need for medical intervention.

[0250] Experimental methods

[0251] 1. Gastrointestinal propulsion function

[0252] ICR mice, half male and half female, with a body weight of 18-22g, were randomly divided into a blank group, a model group, a food group 1 (Bazhen powder, a dose of 20g / kg), a food group 2 (Sishen decoction, a dose of 20g / kg), a Chinese medicine positive group (Shenling Baizhu powder, a dose of 0.48g / kg), a Chinese medicine composition group 1, a Chinese medicine composition group 2, a Chinese medicine composition group 3, a Chinese medicine composition group 4, a Chinese medicine composition group 5, a Chinese medicine composition group 6, a Chinese medicine composition group 7, a Chinese medicine composition group 8, a Chinese medicine composition group 9, a comparative example group 1, a comparative example group 2, and a comparative example group 3, with 10 mice in each group. The drug was administered by gavage once a day for 7 consecutive days. 30 minutes after the last drug administration, 3 mg / kg loperamide was administered by gavage to all other groups except the blank group. Before sampling, the mice were fasted but not water-deprived for 16 hours, and then gavaged with 0.8 mL of carbon powder semi-solid paste. After 15 minutes, the eyeballs were removed to collect blood and separate serum. Small intestinal propulsion rate determination The small intestine was separated and cut from the pylorus to the end of the ileum, and it was naturally laid flat on white glossy paper to measure the total length of the small intestine. The length from the pylorus to the front end of the carbon powder was measured to calculate the small intestinal propulsion rate, which was used to evaluate the gastrointestinal propulsion function. Small intestinal propulsion rate (%) = propulsion length of carbon powder semi-solid paste / total length of small intestine × 100%. The model group is specifically as follows: Functional dyspepsia model (loperamide modeling) Loperamide was prepared to a concentration of 3 mg / kg and administered orally once a day for 7 consecutive days.

[0253] 2. Analgesic effect

[0254] ICR mice, half male and half female, with a body weight of 18-22g, were randomly divided into a blank group, a food group 1 (Bazhen powder, a dose of 20g / kg), a food group 2 (Sishen decoction, a dose of 20g / kg), a Chinese medicine positive group (Shenling Baizhu powder, a dose of 0.48g / kg), a Chinese medicine composition group 1, a Chinese medicine composition group 2, a Chinese medicine composition group 3, a Chinese medicine composition group 4, a Chinese medicine composition group 5, a Chinese medicine composition group 6, a Chinese medicine composition group 7, a Chinese medicine composition group 8, a Chinese medicine composition group 9, a comparative example group 1, a comparative example group 2, and a comparative example group 3, with 10 mice in each group. The drugs were administered orally once a day at a dose of 20g / kg for 7 consecutive days. One hour after the last dose, 0.6% glacial acetic acid (0.1 mL / 10 g) was injected intraperitoneally. The number of writhing times of the mice within 15 minutes after administration was recorded, and the writhing inhibition rate was calculated: writhing inhibition rate (%) = (number of writhing times in the blank group - number of writhing times in the drug administration group) / number of writhing times in the blank group × 100%.

[0255] 3. Anti-inflammatory Effect

[0256] ICR mice, half male and half female, with a body weight of 18-22g, were randomly divided into a blank group, food group 1 (Bazhen powder, dose of 20g / kg), food group 2 (Sishen decoction, dose of 20g / kg), Chinese medicine positive group (Shenling Baizhu powder, dose of 0.48g / kg), Chinese medicine composition group 1, Chinese medicine composition group 2, Chinese medicine composition group 3, Chinese medicine composition group 4, Chinese medicine composition group 5, Chinese medicine composition group 6, Chinese medicine composition group 7, Chinese medicine composition group 8, Chinese medicine composition group 9, comparative example group 1, comparative example group 2, comparative example group 3, 10 mice in each group. The mice were given oral administration once a day at a dose of 20g / kg for 7 consecutive days. One hour after the last administration, 50uL of xylene was applied to both sides of the left ear of the mouse to cause inflammation, and physiological saline was applied to the same position on the right side. After 15 minutes, blood was collected from the eyeballs, and the animals were killed by dislocation of the neck. The same discs of the left and right ears were punched with an 8mm puncher, and the mass was weighed. The swelling degree and swelling inhibition rate were calculated according to the following formula. Swelling degree = mass of the left ear disc - mass of the right ear disc. Ear swelling inhibition rate (%) = (blank group ear swelling degree - drug group ear swelling degree) / blank group ear swelling degree × 100%. The collected blood samples were immediately centrifuged at 3000rpm / min at 4℃ for 15min, and the supernatant was taken and stored in a -20℃ refrigerator. The ELISA method was used to detect the TNF-α and IL-6 levels in the serum.

[0257] 4. Detection of gastric acid pH in mice

[0258] ICR mice, half male and half female, with a body weight of 18-22g, were randomly divided into a blank group, a model group, a food group 1 (Bazhen powder, a dose of 20g / kg), a food group 2 (Sishen decoction, a dose of 20g / kg), a Chinese medicine positive drug group (Shenling Baizhu powder, a dose of 0.48g / kg), a Chinese medicine composition group 1, a Chinese medicine composition group 2, a Chinese medicine composition group 3, a Chinese medicine composition group 4, a Chinese medicine composition group 5, a Chinese medicine composition group 6, a Chinese medicine composition group 7, a Chinese medicine composition group 8, a Chinese medicine composition group 9, a comparative example group 1, a comparative example group 2, and a comparative example group 3, with 10 mice in each group. The mice were given intragastric administration once a day at a dose of 4.68g crude drug / kg for 7 consecutive days. 30 minutes after the last drug administration, all the other groups except the blank group were given 3mg / kg loperamide by intragastric administration. Gastric juice volume determination: After the last administration, mice were fasted but not watered for 16 h. Blood was collected from the mouse eyeballs, and the mice were killed by cervical dislocation. The whole stomach was cut out and the gastric contents were poured out. The total acidity of the gastric juice was obtained by testing with precision pH test paper and comparing with colorimetric cards.

[0259] The model group was specifically: loperamide modeling; specifically, loperamide was prepared into a concentration of 3 mg / kg and administered orally once a day for 7 consecutive days.

[0260] 5. Detection of pepsin and gastrin content in mouse serum

[0261] Blood was collected from the eyeballs of the mice in the above groups, and centrifuged at 3500 r / min for 10 min to separate the serum, which was stored in a -20°C refrigerator and tested according to the instructions of the pepsin and gastrin test kits.

[0262] 6. Statistical Analysis

[0263] Excel statistical analysis was used for data analysis. Data were expressed as x ± s, and one-way analysis of variance was used to compare the sample means among multiple groups. P < 0.05, P < 0.01, P < 0.001 were considered statistically significant.

[0264] Experimental Results

[0265] 1. Gastrointestinal motility function results

[0266] Compared with the blank group, the small intestinal propulsion rate of mice in the model group was significantly decreased (P<0.05). Compared with the model group, the small intestinal propulsion rate of mice in the Chinese medicine combination group was significantly increased (P<0.05). The small intestinal propulsion rate of mice in Chinese medicine combination groups 1-9 was significantly increased (P<0.01). From the results of the small intestinal propulsion rate, it can be seen that among the 9 groups of Chinese medicine combinations, Chinese medicine combination group 4 was superior to the Chinese medicine positive drug group, food group and control group, as shown in Table 1.

[0267] Table 1 Small intestinal propulsion rate of mice in each group (`x±s, n=10)

[0268]

[0269]

[0270] Note: The shoulder marks represent the results of analysis of variance-pairwise comparison. Different letters in the same column represent significant differences (P<0.05), while the same letters in the same column represent insignificant differences (P>0.05).

[0271] 2. Results of analgesic effect

[0272] Compared with the blank group, the number of writhing times of mice in food group 1, Chinese medicine positive drug group and Chinese medicine combination groups 1-9 was significantly reduced (P<0.05). From the results of writhing inhibition rate, it can be seen that among the 9 groups of Chinese medicine combinations, Chinese medicine combination group 4 was superior to the Chinese medicine positive drug group, food group and control group. See Table 2.

[0273] Table 2 Number of writhing times and writhing inhibition rate of mice in each group (`x±s, n=10)

[0274]

[0275] Note: The shoulder marks represent the results of analysis of variance-pairwise comparison. Different letters in the same column represent significant differences (P<0.05), while the same letters in the same column represent insignificant differences (P>0.05).

[0276] 3. Anti-inflammatory effect results

[0277] Compared with the blank group, the ear swelling of mice in the food group, the Chinese medicine positive drug group and the Chinese medicine composition groups 1-9 was significantly reduced (P<0.05). From the results of the ear swelling inhibition rate, it can be seen that among the 9 groups of Chinese medicine compositions, the Chinese medicine composition group 4 was better than the Chinese medicine positive drug group, the food group and the control group, as shown in Table 3.

[0278] Table 3 Ear swelling degree and ear swelling inhibition rate of mice in each group (`x±s, n=10)

[0279]

[0280] Note: The shoulder marks represent the results of analysis of variance-pairwise comparison. Different letters in the same column represent significant differences (P<0.05), while the same letters in the same column represent insignificant differences (P>0.05).

[0281] Compared with the blank group, the TNF-α and IL-6 levels in the serum of the mice in the model group were significantly increased (P<0.05, P<0.05); compared with the model group, the TNF-α and IL-6 levels in the food group 1, food group 2, Chinese medicine positive drug group and Chinese medicine composition groups 1-9 were significantly reduced (P<0.05). Among the 9 groups of Chinese medicine compositions, Chinese medicine composition group 4 was superior to the Chinese medicine positive drug group, food group and control group, as shown in Table 4.

[0282] Table 4 TNF-α and IL-6 levels in serum of mice in each group (`x±s, n=10)

[0283]

[0284] Note: The shoulder marks represent the results of analysis of variance-pairwise comparison. Different letters in the same column represent significant differences (P<0.05), while the same letters in the same column represent insignificant differences (P>0.05).

[0285] 4. Results of gastric acid pH, serum pepsin and gastrin in mice

[0286] Compared with the blank group, the gastric acid pH, serum pepsin and gastrin content of mice in the model group decreased significantly (P<0.05); compared with the model group, the gastric acid pH, serum pepsin and gastrin content of food group 1 and food group 2, Chinese medicine positive drug group, Chinese medicine composition group 1-9 increased significantly (P<0.05, P<0.05). Among the 9 groups of Chinese medicine compositions, Chinese medicine composition group 4 was superior to the Chinese medicine positive drug group, food group and control group, as shown in Table 5.

[0287] Table 5 Gastric acid pH, serum pepsin and gastrin content in each group of mice (`x±s, n=10)

[0288]

[0289] Note: The shoulder marks represent the results of analysis of variance-pairwise comparison. Different letters in the same column represent significant differences (P<0.05), while the same letters in the same column represent insignificant differences (P>0.05).

[0290] in conclusion

[0291] According to the above data results, the four groups of Chinese medicine compositions of the present invention have obvious anti-inflammatory, stomach pain relief, defecation improvement, and gastric function improvement effects. Compared with the positive Chinese medicine group, the effects are significantly different, and the same dosage conditions show significant differences with the food group (P<0.05), which is better than other Chinese medicine composition groups.

[0292] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for gastrointestinal care and conditioning, characterized in that: The invention comprises the following raw materials in parts by weight: 4-8 parts of Chinese herbal medicine extract A, 2-8 parts of Chinese herbal medicine extract B, 4-6 parts of Chinese herbal medicine extract C, and 6-12 parts of Chinese herbal medicine extract D; The preparation method of the Chinese medicine extract A comprises: squeezing coix seeds and almonds to obtain oil and a mixed powder after squeezing; freeze-drying the oil to obtain a freeze-dried powder; mixing the mixed powder after squeezing and the freeze-dried powder to obtain the Chinese medicine extract A; The preparation method of the Chinese medicine extract B comprises: extracting yam and lotus seeds with water to obtain an extract, namely the Chinese medicine extract B; The preparation method of the Chinese medicine extract C comprises: extracting coix seeds, Euryale ferox and apricot kernel by steam distillation, collecting volatile oil, and freeze-drying to obtain; The preparation method of the traditional Chinese medicine extract D comprises: extracting Hericium erinaceus with water and drying the extract.

2. The composition according to claim 1, characterized in that The Chinese medicine composition for gastrointestinal care and conditioning comprises the following raw materials in parts by weight: 6 parts of Chinese medicine extract A, 2 parts of Chinese medicine extract B, 5 parts of Chinese medicine extract C, and 12 parts of Chinese medicine extract D.

3. The composition according to claim 1 or 2, characterized in that The preparation method of the Chinese medicine extract A comprises: S1) crushing coix seeds and almonds, drying, pressing oil, filtering, and obtaining oil and pressed mixed powder; the mass ratio of coix seeds to almonds is 10:15; the drying is performed at 50° C. for 4 hours; the filtering is performed by filtering through a 400-mesh filter cloth; S2) freeze-drying the oil to obtain a freeze-dried powder; S3) drying the squeezed mixed powder and mixing it with the freeze-dried powder to obtain the Chinese medicine extract A; the drying is performed at 70° C. for 8 hours.

4. The composition according to claim 1 or 2, characterized in that In the preparation method of the Chinese medicine extract B: The mass ratio of yam to lotus seed is 8:4; the solid-liquid ratio of water extraction is 1:10-20; the water extraction is performed twice, and the time of each extraction is 1 hour; the relative density of the extract is 1.05-1.

10.

5. The composition according to claim 1 or 2, characterized in that In the preparation method of the traditional Chinese medicine extract C: coix seed, euryale ferox and almond are soaked in water and extracted by steam distillation; the mass ratio of coix seed, euryale ferox and almond is 7:10:7; the solid-liquid ratio of steam distillation extraction is 1:10; the soaking time is 1 hour; and the steam distillation extraction time is 6 hours.

6. The composition according to claim 2, characterized in that The preparation method of the traditional Chinese medicine extract D comprises: soaking Hericium erinaceus in water, extracting, and drying to obtain the extract; the mass ratio of Hericium erinaceus to water is 1:10; the soaking time is 1 hour; the extraction times are 2 times; and the extraction time is 1 hour.

7. A method for preparing the Chinese medicine composition for gastrointestinal care and conditioning according to any one of claims 1 to 6, characterized in that: The steps include: The Chinese herbal medicine extract A, the Chinese herbal medicine extract B, the Chinese herbal medicine extract C and the Chinese herbal medicine extract D are mixed to obtain the product.

8. Use of the composition according to any one of claims 1 to 6 or the composition prepared by the preparation method according to claim 8 in the preparation of gastrointestinal care and conditioning products.

9. The use according to claim 8, characterized in that: The gastrointestinal care and conditioning include anti-inflammation, relieving stomach pain, improving bowel movements and / or improving gastric function.

10. A medicine for gastrointestinal care and conditioning, characterized in that: The invention comprises the composition according to any one of claims 1 to 7 or the composition prepared by the preparation method according to claim 8.

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