Light-enhanced mass spectrum detection and acquisition system and method

Abstract

The invention belongs to the technical field of mass spectrum detection, and particularly relates to a light-enhanced mass spectrum detection acquisition system and method.The light-enhanced mass spectrum detection acquisition system comprises a main control module serving as a system control center, a man-machine interaction module used for achieving a man-machine interaction function, a vacuum environment construction module used for constructing a vacuum detection environment and a sample injection module, the sample conveying module is used for conveying samples, the ion source module is used for converting sample molecules into charged ions, the mass analysis module is used for carrying out mass spectrum separation, the signal detection module is used for detecting and amplifying collected mass spectrum signals, and the data processing module is used for processing and analyzing the detected mass spectrum signals. According to the invention, non-contact control on ions is realized by using a light pressure effect, so that ion loss can be effectively reduced, and the mass spectrum separation efficiency of the ions in the mass spectrum separation process is remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry detection, and in particular to a light-enhanced mass spectrometry detection acquisition system and method. Background Art

[0002] Mass spectrometry is an important analytical method widely used in the fields of chemistry, biology, medicine and environmental monitoring. It determines the mass-to-charge ratio by measuring the motion behavior of charged particles in an electric field or magnetic field, thereby realizing qualitative and quantitative analysis of sample components. With the continuous development of science and technology, mass spectrometry has made significant progress in sensitivity, resolution and detection speed, providing strong support for scientific research and practical applications. In the process of mass spectrometry detection, sample collection and separation are key links. The existing mass spectrometry acquisition method mainly relies on the guidance and focusing of ions by electric or magnetic fields, which has the following defects: First, due to factors such as ion energy dispersion, ion source instability or high sample complexity, the existing acquisition method is difficult to achieve efficient ion collection; second, the existing voltage acquisition circuit cannot meet the needs of high-precision mass spectrometry signal acquisition; third, mass spectrometry data often contains a lot of noise, and the existing mass spectrometry detection acquisition system generally uses filters or statistical methods for denoising, which has limited ability to handle complex noise and cannot achieve ideal denoising effect. Therefore, a light-enhanced mass spectrometry detection acquisition system and method are invented. Summary of the invention

[0003] In view of the above-mentioned problems and / or the problems existing in the existing light-enhanced mass spectrometry detection and acquisition system and method, the present invention is proposed.

[0004] Therefore, the object of the present invention is to provide a light-enhanced mass spectrometry detection and acquisition system and method, which can solve the above-mentioned existing problems.

[0005] To solve the above technical problems, according to one aspect of the present invention, the present invention provides the following technical solutions:

[0006] A light-enhanced mass spectrometry detection and acquisition system, comprising:

[0007] It is the main control module of the system control center;

[0008] Human-computer interaction module, used to realize human-computer interaction function;

[0009] Vacuum environment building module, used to build a vacuum detection environment;

[0010] A sample injection module, used for delivering samples;

[0011] An ion source module, used to convert sample molecules into charged ions;

[0012] A mass analysis module for mass spectrometry separation;

[0013] A signal detection module, used to detect and amplify the collected mass spectrometry signal;

[0014] A data processing module is used to process and analyze the detected mass spectrometry signals and extract useful information;

[0015] The light pressure enhancement module is used to non-contactly manipulate ions through the light pressure effect to improve the collection efficiency of ions during mass spectrometry separation;

[0016] A collection circuit module, used for collecting voltage signals;

[0017] The main control module is electrically connected to the human-computer interaction module, the vacuum environment construction module, the sampling module, the ion source module, the mass analysis module, the signal detection module, the data processing module, the light pressure enhancement module and the acquisition circuit module respectively.

[0018] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition system described in the present invention, the data processing module includes:

[0019] A preprocessing unit for denoising the data;

[0020] Feature extraction unit, used to extract meaningful features from complex mass spectrometry data;

[0021] Data alignment unit, used to align features based on mass-to-charge ratio and retention time to eliminate drift and offset;

[0022] Data cleaning unit, used to remove abnormal peaks and fill missing peaks;

[0023] Data analysis unit, used for differential expression analysis, cluster analysis and metabolic pathway analysis;

[0024] The preprocessing unit establishes a data connection with the feature extraction unit, the feature extraction unit establishes a data connection with the data alignment unit, the data alignment unit establishes a data connection with the data cleaning unit, and the data cleaning unit establishes a data connection with the data analysis unit.

[0025] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition system described in the present invention, the light pressure enhancement module includes:

[0026] A control unit, used to control the magnitude and direction of the light pressure effect so that the ions are gathered in the collection area;

[0027] A light source unit, used to generate a high-energy, high-directional light source;

[0028] A focusing unit, used for focusing the light beam emitted by the light source into a collection area;

[0029] A monitoring unit is used to monitor the influence of light pressure effect on ion behavior and provide data support for the control unit;

[0030] An interface unit, used to realize connection with a main control module;

[0031] The control unit is electrically connected to the light source unit, the focusing unit, the monitoring unit and the interface unit respectively.

[0032] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition system described in the present invention, the acquisition circuit module includes:

[0033] A voltage collection circuit, used for collecting voltage data;

[0034] A voltage isolation circuit, used to realize a voltage isolation function;

[0035] The voltage collection circuit and the voltage isolation circuit establish an electrical connection;

[0036] The voltage isolation circuit comprises:

[0037] An input unit, used to receive the input signal and convert it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit;

[0038] An optical coupling transmission unit, used to realize linear transmission from input signal to output signal;

[0039] An output unit, used to convert the optical signal back into an electrical signal and output a voltage signal having a precise linear relationship with the input voltage;

[0040] A noise reduction unit, used to reduce the output noise of the circuit;

[0041] Protection unit to avoid circuit damage;

[0042] The optical coupling transmission unit is electrically connected to the input unit, the output unit, the noise reduction unit and the protection unit respectively.

[0043] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition system described in the present invention, wherein: the input unit includes a transistor Q1 and an operational amplifier U1;

[0044] The optical coupling transmission unit includes a light emitting diode LED, a photodiode PD1 and a photodiode PD2, and the optical coupling transmission unit adopts a HCNR201 optical coupler;

[0045] The output unit includes an operational amplifier U2 and a potentiometer R1;

[0046] The noise reduction unit includes a capacitor C1 and a capacitor C2;

[0047] The protection unit is a diode D1;

[0048] Pin 6 of the operational amplifier U1 and pin 7 of the operational amplifier U1 are connected in series through capacitor C1, pin 7 of the operational amplifier U1 is connected to the base of transistor Q1, the collector of the transistor Q1 is connected to the input end of the light emitting diode LED, the input end of the diode LED is connected to the output end of the diode D1, the output end of the diode LED is connected to the input end of the diode D1, pin 6 of the operational amplifier U1 is connected to the input end of the photodiode PD1, pin 6 of the operational amplifier U2 is connected to the input end of the photodiode PD2, the output end of the photodiode PD2 is connected to pin 5 of the operational amplifier U2, pin 6 of the operational amplifier U2 and pin 7 of the operational amplifier U2 are connected in parallel with potentiometer R1 and capacitor C2, and the models of the operational amplifier U1 and the operational amplifier U2 are OP27.

[0049] A light-enhanced mass spectrometry detection and collection method comprises the following specific steps:

[0050] Step 1: sample introduction: the sample to be tested is introduced into the detection environment through the sample introduction module, and the vacuum environment construction module is used to create a vacuum in the detection environment;

[0051] Step 2, ionization: using the ion source module to convert sample molecules into charged ions;

[0052] Step 3, mass analysis: using the mass analysis module to separate the charged ions by mass spectrometry according to the mass-to-charge ratio;

[0053] Step 4: Data processing: Use the signal detection module to detect and amplify the collected mass spectrometry signal, and use the data processing module to process and analyze the detected mass spectrometry signal to extract useful information.

[0054] As a preferred scheme of the light-enhanced mass spectrometry detection and acquisition method described in the present invention, wherein: in the step three, during the mass spectrometry separation process, the light pressure enhancement module is used to enhance the ion collection efficiency, and high-precision voltage collection is achieved through the collection circuit module to ensure the accurate acquisition of the mass spectrometry signal.

[0055] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition method described in the present invention, the specific principle of the light pressure enhancement module is: using the light source unit to generate a high-energy, high-directional light source, using the focusing unit to focus the light beam emitted by the light source to the collection area, using the control unit to control the size and direction of the light pressure effect so that the ions gather in the collection area, using the monitoring unit to monitor the influence of the light pressure effect on the behavior of the ions, providing data support for the control unit, and using the interface unit to achieve connection with the main control module.

[0056] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition method described in the present invention, the specific principle of the voltage isolation circuit in the acquisition circuit module is: using an input unit to receive an input signal and convert it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit, using an optical coupling transmission unit to achieve linear transmission from input signal to output signal, using an output unit to convert the optical signal back into an electrical signal, and outputting a voltage signal with a precise linear relationship with the input voltage, using a noise reduction unit to reduce the output noise of the circuit, and using a protection unit to avoid circuit damage.

[0057] As a preferred solution of the light-enhanced mass spectrometry detection and acquisition method described in the present invention, wherein: in the step four, the data processing module uses a preprocessing unit to denoise the data, and the denoising process is implemented by a deep learning model. The deep learning model uses the mass spectrometry data with added noise as input and the original noise-free mass spectrometry data as the target output, and is trained in this way.

[0058] Compared with existing technologies:

[0059] The present invention realizes non-contact manipulation of ions by utilizing the photopressure effect, which can effectively reduce ion loss and significantly improve the ion in the mass spectrometry separation process; the present invention adopts a voltage acquisition isolation circuit based on a high-precision linear optocoupler, which can reduce the influence of environmental noise and realize low-noise and high-sensitivity acquisition of signals; the present invention realizes data denoising function through a deep learning model, and has better denoising effect on nonlinear, non-Gaussian distributed or time-varying complex noise. BRIEF DESCRIPTION OF THE DRAWINGS

[0060] Figure 1 is a system structure block diagram of the present invention;

[0061] Figure 2 It is a structural block diagram of the data processing module of the present invention;

[0062] Figure 3 This is a structural block diagram of the light pressure enhancement module of the present invention;

[0063] Figure 4 It is a structural block diagram of the acquisition circuit module of the present invention;

[0064] Figure 5 It is a schematic diagram of a voltage isolation circuit of the present invention;

[0065] Figure 6 The present invention is a flow chart of the method.

[0066] In the figure: 1. main control module; 2. human-computer interaction module; 3. vacuum environment construction module; 4. injection module; 5. ion source module; 6. mass analysis module; 7. signal detection module; 8. data processing module; 81. preprocessing unit; 82. feature extraction unit; 83. data alignment unit; 84. data cleaning unit; 85. data analysis unit; 9. light pressure enhancement module; 91. control unit; 92. light source unit; 93. focusing unit; 94. monitoring unit; 95. interface unit; 10. acquisition circuit module; 101. voltage acquisition circuit; 102. voltage isolation circuit; 1021. input unit; 1022. optical coupling transmission unit; 1023. output unit; 1024. noise reduction unit; 1025. protection unit. DETAILED DESCRIPTION

[0067] In order to make the objectives, technical solutions and advantages of the present invention more clear, the embodiments of the present invention will be further described in detail below with reference to the accompanying drawings.

[0068] The present invention provides a light-enhanced mass spectrometry detection and acquisition system, please refer to Figure 1-Figure 6 ;

[0069] It includes: a main control module 1 for the system control center, a human-computer interaction module 2 for realizing the human-computer interaction function, a vacuum environment construction module 3 for constructing a vacuum detection environment, a sample injection module 4 for transporting samples, an ion source module 5 for converting sample molecules into charged ions, a mass analysis module 6 for performing mass spectrometry separation, a signal detection module 7 for detecting and amplifying the collected mass spectrometry signals, a data processing module 8 for processing and analyzing the detected mass spectrometry signals to extract useful information, a light pressure enhancement module 9 for non-contact manipulation of ions through light pressure effect to improve the collection efficiency of ions in the mass spectrometry separation process, and a collection circuit module 10 for collecting voltage signals;

[0070] The main control module 1 establishes electrical connections with the human-computer interaction module 2, the vacuum environment construction module 3, the sampling module 4, the ion source module 5, the mass analysis module 6, the signal detection module 7, the data processing module 8, the light pressure enhancement module 9 and the acquisition circuit module 10 respectively.

[0071] The data processing module 8 includes: a preprocessing unit 81 for denoising the data, a feature extraction unit 82 for extracting meaningful features from complex mass spectrometry data, a data alignment unit 83 for aligning features according to their mass-to-charge ratio and retention time to eliminate drift and offset, a data cleaning unit 84 for removing abnormal peaks and filling missing peaks, and a data analysis unit 85 for performing differential expression analysis, cluster analysis, and metabolic pathway analysis;

[0072] The preprocessing unit 81 establishes a data connection with the feature extraction unit 82 , the feature extraction unit 82 establishes a data connection with the data alignment unit 83 , the data alignment unit 83 establishes a data connection with the data cleaning unit 84 , and the data cleaning unit 84 establishes a data connection with the data analysis unit 85 .

[0073] The light pressure enhancement module 9 includes: a control unit 91, which is used to control the size and direction of the light pressure effect so that the ions are gathered in the collection area, a light source unit 92, which is used to generate a high-energy, high-directional light source, a focusing unit 93, which is used to focus the light beam emitted by the light source into the collection area, a monitoring unit 94, which is used to monitor the influence of the light pressure effect on the behavior of the ions and provide data support for the control unit 91, and an interface unit 95, which is used to achieve connection with the main control module 1;

[0074] The control unit 91 establishes electrical connections with the light source unit 92 , the focusing unit 93 , the monitoring unit 94 and the interface unit 95 respectively.

[0075] The acquisition circuit module 10 includes: a voltage acquisition circuit 101 for acquiring voltage data, a voltage isolation circuit 102 for realizing a voltage isolation function, an electrical connection between the voltage acquisition circuit 101 and the voltage isolation circuit 102, the voltage isolation circuit 102 includes: an input unit 1021 for receiving an input signal and converting it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit, an optical coupling transmission unit 1022 for realizing a linear transmission from an input signal to an output signal, an output unit 1023 for converting the optical signal back into an electrical signal and outputting a voltage signal having a precise linear relationship with the input voltage, a noise reduction unit 1024 for reducing the output noise of the circuit, and a protection unit 1025 for preventing the circuit from being damaged;

[0076] The optical coupling transmission unit 1022 establishes electrical connections with the input unit 1021 , the output unit 1023 , the noise reduction unit 1024 and the protection unit 1025 , respectively.

[0077] The input unit 1021 includes a transistor Q1 and an operational amplifier U1; the optical coupling transmission unit 1022 includes a light emitting diode LED, a photodiode PD1 and a photodiode PD2, and the optical coupling transmission unit 1022 adopts a HCNR201 optical coupler; the output unit 1023 includes an operational amplifier U2 and a potentiometer R1; the noise reduction unit 1024 includes a capacitor C1 and a capacitor C2; the protection unit 1025 is a diode D1;

[0078] Pin 6 of op amp U1 and pin 7 of op amp U1 are connected in series through capacitor C1, pin 7 of op amp U1 is connected to the base of transistor Q1, the collector of transistor Q1 is connected to the input end of light emitting diode LED, the input end of diode LED is connected to the output end of diode D1, the output end of diode LED is connected to the input end of diode D1, pin 6 of op amp U1 is connected to the input end of photodiode PD1, pin 6 of op amp U2 is connected to the input end of photodiode PD2, the output end of photodiode PD2 is connected to pin 5 of op amp U2, pin 6 of op amp U2 and pin 7 of op amp U2 are connected in parallel with potentiometer R1 and capacitor C2, and the models of op amp U1 and op amp U2 are OP27.

[0079] A light-enhanced mass spectrometry detection and collection method comprises the following specific steps:

[0080] Step 1: sample introduction: the sample to be tested is introduced into the detection environment through the sample introduction module 4, and the vacuum environment construction module 3 is used to create a vacuum in the detection environment;

[0081] Step 2, ionization: using the ion source module 5 to convert sample molecules into charged ions;

[0082] Step 3, mass analysis: The charged ions are separated by mass spectrometry according to the mass-to-charge ratio using the mass analysis module 6. During the mass spectrometry separation process, the light pressure enhancement module 9 is used to enhance the ion collection efficiency, and the collection circuit module 10 is used to achieve high-precision voltage collection to ensure accurate acquisition of mass spectrometry signals;

[0083] in:

[0084] The specific principle of the light pressure enhancement module 9 is as follows: using the light source unit 92 to generate a high-energy, high-directional light source, using the focusing unit 93 to focus the light beam emitted by the light source to the collection area, using the control unit 91 to control the size and direction of the light pressure effect so that the ions gather in the collection area, using the monitoring unit 94 to monitor the influence of the light pressure effect on the behavior of the ions, providing data support for the control unit 91, and using the interface unit 95 to achieve connection with the main control module 1;

[0085] The specific principle of the voltage isolation circuit 102 in the acquisition circuit module 10 is as follows: using the input unit 1021 to receive the input signal and convert it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit, using the optical coupling transmission unit 1022 to achieve linear transmission from the input signal to the output signal, using the output unit 1023 to convert the optical signal back into an electrical signal, and output a voltage signal with a precise linear relationship with the input voltage, using the noise reduction unit 1024 to reduce the output noise of the circuit, and using the protection unit 1025 to avoid circuit damage;

[0086] Step 4, data processing: the collected mass spectrometry signal is detected and amplified by the signal detection module 7, and the detected mass spectrometry signal is processed and analyzed by the data processing module 8 to extract useful information, wherein the data processing module 8 uses the preprocessing unit 81 to denoise the data, and the denoising process is implemented by a deep learning model, which uses the mass spectrometry data with added noise as input and the original noise-free mass spectrometry data as the target output, and is trained in this way. Specifically, it can be expressed as:

[0087]

[0088] Where n represents the number of samples. i ) is the input mass spectrum data containing white noise. i is the original noise-free mass spectrum data. P(Y|N(X)) is the conditional probability distribution of generating the corresponding noise-free mass spectrum data Y given the noisy mass spectrum data N(X).

[0089] Based on the above, the advantage of the present invention is that when the present invention is used, the sample to be tested is first introduced into the detection environment through the sample injection module 4, the vacuum environment construction module 3 is used to create a vacuum in the detection environment, and then the sample molecules are converted into charged ions by the ion source module 5, and then the charged ions are subjected to mass spectrometry separation according to the mass-to-charge ratio by the mass analysis module 6. At the same time, the light pressure enhancement module 9 is used to enhance the collection efficiency of the ions, and the high-precision voltage collection is achieved through the collection circuit module 10 to ensure the accurate acquisition of the mass spectrum signal. Finally, the signal detection module 7 is used to detect and amplify the collected mass spectrum signal, and the data processing module 8 is used to process the detected mass spectrum signal. Process and analyze to extract useful information; the light pressure enhancement module 9 uses the light source unit 92 to generate a high-energy, high-directional light source, uses the focusing unit 93 to focus the light beam emitted by the light source to the collection area, uses the control unit 91 to control the size and direction of the light pressure effect, so that the ions gather in the collection area, uses the monitoring unit 94 to monitor the influence of the light pressure effect on the behavior of the ions, provides data support for the control unit 91, uses the interface unit 95 to achieve connection with the main control module 1, the acquisition circuit module 10 uses the voltage acquisition circuit 101 to collect voltage data, uses the voltage isolation circuit 102 to achieve the voltage isolation function, and the voltage isolation circuit 102 The input unit 1021 is used to receive the input signal and convert it into an optical signal, and a negative feedback mechanism is formed to ensure the stability and linearity of the circuit. The optical coupling transmission unit 1022 is used to realize the linear transmission from the input signal to the output signal. The output unit 1023 is used to convert the optical signal back into an electrical signal, and output a voltage signal with a precise linear relationship with the input voltage. The noise reduction unit 1024 is used to reduce the output noise of the circuit, and the protection unit 1025 is used to avoid circuit damage. Specifically, when the input voltage changes, under the action of the operational amplifier U1, the LED current IF is adjusted accordingly; the physical structure of the optocoupler determines that PD1 is linearly proportional to the LED. , so the current IPD1 flowing through PD1 changes with the input voltage; PD2 is in strict proportional relationship with PD1, and IPD2 also changes with the input voltage. IPD2 is converted into output voltage through operational amplifier U2 and potentiometer R1, and finally a precise linear relationship between output voltage and input voltage is achieved. Compensation capacitors C1 and C2 are used to improve circuit stability, reduce circuit output noise and limit the circuit's operating bandwidth to about 10kHz; diode D1 plays a freewheeling role to prevent excessive reverse voltage from being applied to both ends of the LED when the LED is completely turned off; main control module 1 is the control center of the system, and human-computer interaction module 2 is used for data visualization and command input;After receiving the data, the data processing module 8 uses the preprocessing unit 81 to denoise the data. The preprocessing unit 81 is constructed based on deep learning technology, and uses the feature extraction unit 82 to extract meaningful features from complex mass spectrometry data. The data alignment unit 83 aligns the features according to their mass-to-charge ratio and retention time to eliminate drift and offset. The data cleaning unit 84 removes abnormal peaks and fills in missing peaks. The data analysis unit 85 performs differential expression analysis, cluster analysis, and metabolic pathway analysis. ;

[0090] Although the present invention has been described above with reference to the embodiments, various modifications may be made thereto and parts thereof may be replaced by equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the various features in the embodiments disclosed in the present invention may be used in combination with each other in any manner, and the fact that these combinations are not exhaustively described in this specification is only for the sake of omitting space and saving resources. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A light-enhanced mass spectrometry detection and acquisition system, characterized in that: include: A main control module (1) of the system control center; A human-computer interaction module (2), used to realize a human-computer interaction function; A vacuum environment building module (3), used for building a vacuum detection environment; A sample injection module (4), used for delivering a sample; An ion source module (5), used for converting sample molecules into charged ions; A mass analysis module (6), used for performing mass spectrometry separation; A signal detection module (7), used for detecting and amplifying the collected mass spectrometry signal; A data processing module (8) is used to process and analyze the detected mass spectrometry signals to extract useful information; A light pressure enhancement module (9) is used for non-contact manipulation of ions through light pressure effect, thereby improving the collection efficiency of ions in the mass spectrometry separation process; A collection circuit module (10), used for collecting voltage signals; The main control module (1) is electrically connected to the human-computer interaction module (2), the vacuum environment construction module (3), the sampling module (4), the ion source module (5), the mass analysis module (6), the signal detection module (7), the data processing module (8), the light pressure enhancement module (9) and the acquisition circuit module (10).

2. The light-enhanced mass spectrometry detection and acquisition system according to claim 1, characterized in that: The data processing module (8) comprises: A preprocessing unit (81), used for denoising the data; A feature extraction unit (82), used to extract meaningful features from complex mass spectrometry data; A data alignment unit (83) for performing alignment according to the mass-to-charge ratio and retention time of the features to eliminate drift and offset; A data cleaning unit (84) for removing abnormal peaks and filling missing peaks; A data analysis unit (85), used for differential expression analysis, cluster analysis and metabolic pathway analysis; The preprocessing unit (81) establishes a data connection with the feature extraction unit (82), the feature extraction unit (82) establishes a data connection with the data alignment unit (83), the data alignment unit (83) establishes a data connection with the data cleaning unit (84), and the data cleaning unit (84) establishes a data connection with the data analysis unit (85).

3. The light-enhanced mass spectrometry detection and acquisition system according to claim 1, characterized in that: The light pressure enhancement module (9) comprises: A control unit (91) for controlling the magnitude and direction of the light pressure effect so that the ions are gathered in the collection area; A light source unit (92) for generating a high-energy, high-directional light source; A focusing unit (93), used for focusing the light beam emitted by the light source onto a collection area; A monitoring unit (94), used to monitor the influence of the light pressure effect on the behavior of the ions and provide data support for the control unit (91); An interface unit (95) for realizing connection with a main control module (1); The control unit (91) establishes electrical connections with the light source unit (92), the focusing unit (93), the monitoring unit (94) and the interface unit (95) respectively.

4. The light-enhanced mass spectrometry detection and acquisition system according to claim 1, characterized in that: The acquisition circuit module (10) comprises: A voltage collection circuit (101), used for collecting voltage data; A voltage isolation circuit (102), used to implement a voltage isolation function; The voltage collection circuit (101) and the voltage isolation circuit (102) establish an electrical connection; The voltage isolation circuit (102) comprises: An input unit (1021) is used to receive an input signal and convert it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit; An optical coupling transmission unit (1022), used to realize linear transmission from an input signal to an output signal; An output unit (1023) for converting the optical signal back into an electrical signal and outputting a voltage signal having a precise linear relationship with the input voltage; A noise reduction unit (1024), used to reduce output noise of the circuit; A protection unit (1025) for preventing circuit damage; The optical coupling transmission unit (1022) establishes electrical connections with the input unit (1021), the output unit (1023), the noise reduction unit (1024) and the protection unit (1025) respectively.

5. The light-enhanced mass spectrometry detection and collection system according to claim 4, characterized in that: The input unit (1021) comprises a transistor Q1 and an operational amplifier U1; The optical coupling transmission unit (1022) comprises a light emitting diode LED, a photodiode PD1 and a photodiode PD2, and the optical coupling transmission unit (1022) adopts a HCNR201 optical coupler; The output unit (1023) includes an operational amplifier U2 and a potentiometer R1; The noise reduction unit (1024) comprises a capacitor C1 and a capacitor C2; The protection unit (1025) is a diode D1; Pin 6 of the operational amplifier U1 and pin 7 of the operational amplifier U1 are connected in series through capacitor C1, pin 7 of the operational amplifier U1 is connected to the base of transistor Q1, the collector of the transistor Q1 is connected to the input end of the light emitting diode LED, the input end of the diode LED is connected to the output end of the diode D1, the output end of the diode LED is connected to the input end of the diode D1, pin 6 of the operational amplifier U1 is connected to the input end of the photodiode PD1, pin 6 of the operational amplifier U2 is connected to the input end of the photodiode PD2, the output end of the photodiode PD2 is connected to pin 5 of the operational amplifier U2, pin 6 of the operational amplifier U2 and pin 7 of the operational amplifier U2 are connected in parallel with potentiometer R1 and capacitor C2, and the models of the operational amplifier U1 and the operational amplifier U2 are OP27.

6. A light-enhanced mass spectrometry detection and collection method, characterized in that: The specific steps are as follows: Step 1, sample introduction: introducing the sample to be tested into the detection environment through the sample introduction module (4), and creating a vacuum in the detection environment using the vacuum environment construction module (3); Step 2, ionization: using the ion source module (5) to convert sample molecules into charged ions; Step 3, mass analysis: using the mass analysis module (6) to separate the charged ions by mass spectrometry according to the mass-to-charge ratio; Step 4: Data processing: The signal detection module (7) is used to detect and amplify the collected mass spectrometry signal, and the data processing module (8) is used to process and analyze the detected mass spectrometry signal to extract useful information.

7. The light-enhanced mass spectrometry detection and collection method according to claim 6, characterized in that: In the step three, during the mass spectrometry separation process, the light pressure enhancement module (9) is used to enhance the ion collection efficiency, and the collection circuit module (10) is used to achieve high-precision voltage collection, thereby ensuring accurate acquisition of mass spectrometry signals.

8. The light-enhanced mass spectrometry detection and collection method according to claim 7, characterized in that: The specific principle of the light pressure enhancement module (9) is as follows: a light source unit (92) is used to generate a high-energy, high-directional light source; a focusing unit (93) is used to focus the light beam emitted by the light source onto a collection area; a control unit (91) is used to control the size and direction of the light pressure effect so that ions are gathered into the collection area; a monitoring unit (94) is used to monitor the influence of the light pressure effect on the behavior of the ions and provide data support for the control unit (91); and an interface unit (95) is used to achieve connection with the main control module (1).

9. The light-enhanced mass spectrometry detection and collection method according to claim 8, characterized in that: The specific principle of the voltage isolation circuit (102) in the acquisition circuit module (10) is as follows: an input unit (1021) is used to receive an input signal and convert it into an optical signal, while forming a negative feedback mechanism to ensure the stability and linearity of the circuit; an optical coupling transmission unit (1022) is used to realize the linear transmission from the input signal to the output signal; an output unit (1023) is used to convert the optical signal back into an electrical signal and output a voltage signal having a precise linear relationship with the input voltage; a noise reduction unit (1024) is used to reduce the output noise of the circuit; and a protection unit (1025) is used to avoid circuit damage.

10. The light-enhanced mass spectrometry detection and collection method according to claim 6, characterized in that: In the step 4, the data processing module (8) uses the preprocessing unit (81) to denoise the data. The denoising process is implemented by a deep learning model. The deep learning model uses the mass spectrometry data with added noise as input and the original noise-free mass spectrometry data as the target output, and is trained in this way.

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