Anti-inflammatory toothpaste and preparation method thereof

Abstract

The invention discloses anti-inflammatory toothpaste and a preparation method thereof. The anti-inflammatory toothpaste is prepared from the following raw material components in parts by weight: 0.05 to 0.5 part of a plantain fruit extract, 0.1 to 2.0 parts of a mulberry bark extract, 0.01 to 0.2 part of a stephania tetrandra extract, 0.1 to 0.5 part of a witch hazel extract, 0.1 to 1 part of a commeline communis extract, 35 to 45 parts of calcium carbonate, 2 to 8 parts of silicon dioxide, 2 to 5 parts of polyethylene glycol, 20 to 30 parts of sorbitol, 0.2 to 0.5 part of methylparaben, 0.5 to 0.8 part of sodium lauryl sulfate, 0.5 to 0.8 part of carboxymethyl cellulose sodium and 0.1 to 0.4 part of xanthan gum. The hand sanitizer comprises the following components in parts by weight: 0.1-0.5 part of benzyl alcohol, 0.2-0.5 part of saccharin sodium salt, 0.1-0.2 part of propyl hydroxybenzoate, 0.8-1.2 parts of essence and 15-25 parts of water. By adding the compound herbal extract into the toothpaste formula, the anti-inflammatory effect of the toothpaste is improved, meanwhile, the preparation method is optimized and improved, and the stability of the product quality is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of toothpaste, and particularly relates to an anti-inflammatory toothpaste and a preparation method thereof. Background Art

[0002] Toothpaste is a necessity for cleaning teeth in daily life. Toothpaste should have a good effect of cleaning the oral cavity and the surrounding environment, be non-toxic, non-irritating, have good stability, be easy to clean teeth and toothbrushes, be easy to use, and have a comfortable fragrance and a refreshing feeling. In order to meet the needs of different groups of people, toothpastes with different functions are launched on the market. For example, sweeteners and flavorings were added to toothpaste in the early days to improve the taste and encourage children to use it more, or whitening toothpaste with whitening ingredients. With the continuous development of science and technology, more functional products have emerged, such as natural toothpaste, anti-inflammatory toothpaste, gum care toothpaste, and fluoride toothpaste to prevent caries.

[0003] At present, the formulas of toothpastes with anti-inflammatory effects on the market are mostly added with certain chemical drugs and antibiotics, such as fluoride. As consumers favor natural ingredients, anti-inflammatory toothpastes that do not contain SLS (sodium lauryl sulfate), preservatives, or fluoride are gradually becoming popular in the market. For example, herbal or plant extracts are added to the toothpaste formula, but usually only one or two plant extracts are added, and their anti-inflammatory effect is not as good as that of chemical toothpaste. Moreover, due to the influence of processing conditions such as the extraction method, the content of active ingredients in Chinese herbal extracts varies greatly, which affects the stability of product quality. Summary of the invention

[0004] In view of the above-mentioned shortcomings, the present invention discloses an anti-inflammatory toothpaste and a preparation method thereof, which improves the anti-inflammatory effect of the toothpaste by adding a composite herbal extract into the toothpaste formula, and at the same time optimizes and improves the preparation method to improve the stability of product quality.

[0005] The present invention is achieved by adopting the following technical solutions: An anti-inflammatory toothpaste comprises the following raw material components in parts by weight: 0.05-0.5 parts of plantain fruit extract, 0.1-2.0 parts of mulberry bark extract, 0.01-0.2 parts of stephania tetrandra extract, 0.1-0.5 parts of witch hazel extract, 0.1-1 parts of euphorbia pulegosa extract, 35-45 parts of calcium carbonate, 2-8 parts of silicon dioxide, 2-5 parts of polyethylene glycol, 20-30 parts of sorbitol, 0.2-0.5 parts of methylparaben, 0.5-0.8 parts of sodium lauryl sulfate, 0.5-0.8 parts of sodium hydroxymethylcellulose, 0.1-0.4 parts of xanthan gum, 0.1-0.5 parts of benzyl alcohol, 0.2-0.5 parts of sodium saccharin, 0.1-0.2 parts of propylparaben, 0.8-1.2 parts of flavor and 15-25 parts of water.

[0006] Furthermore, the preparation method of the banana fruit extract is as follows: firstly crush the banana fruit, then extract it twice with 50% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, then stand overnight, then take the supernatant and pass it through a macroporous adsorption resin, then elute it with deionized water until it is colorless, then elute impurities with 20% to 40% ethanol, finally elute it with 60 to 80% ethanol and collect the eluate, decompress and concentrate the collected eluate and dry it to obtain the banana fruit extract; The plantain fruit is the fruit of Musa sapientum, which has a straight shape, obvious edges and corners, a thick and tough peel, an apricot-yellow flesh, and a sweet and sour taste.

[0007] The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the Stephania tetrandra extract is as follows: firstly crush the Stephania tetrandra, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the Stephania tetrandra extract.

[0008] The preparation method of the witch hazel extract is as follows: crushing the witch hazel, then extracting it twice with an extractant, combining the extracts and adding 70% ethanol to extract, so as to obtain a precipitate and a supernatant A, then adding 80% ethanol to the precipitate for extraction twice, combining the supernatants to obtain a supernatant B, and evenly mixing the supernatant A and the supernatant B and concentrating them under reduced pressure until there is no alcohol taste, so as to obtain the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1;.

[0009] The preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate them, then precipitate with 70% ethanol, filter and recover the ethanol solution and add water to precipitate, and filter and remove water to obtain the duckweed extract.

[0010] Furthermore, the content of plantain fruit saponin in the plantain fruit extract is ≥20%; the content of solid matter (i.e., water-insoluble substances) in the mulberry bark extract is ≥2%; the content of tetrandrin in the stephencirias extract is ≥0.5%; the content of tannin in the witch hazel extract is ≥4.3 mg / kg; and the content of extract in the ophiopogonis extract is ≥20%.

[0011] Furthermore, the anti-inflammatory toothpaste includes the following raw material components in parts by weight: 40 parts of calcium carbonate, 4 parts of silicon dioxide, 4 parts of polyethylene glycol, 25 parts of sorbitol, 0.2 parts of methylparaben, 2.5 parts of sodium lauryl sulfate, 0.8 parts of sodium hydroxymethylcellulose, 0.3 parts of xanthan gum, 0.3 parts of benzyl alcohol, 0.3 parts of sodium saccharin, 0.1 parts of propylparaben, 1.0 parts of flavor, and 20 parts of water.

[0012] The preparation method of the anti-inflammatory toothpaste comprises the following steps: (1) weighing raw material components according to proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogonis extract, saccharin sodium and water to obtain a premix; (2) mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, and sorbitol with the premix obtained in step (1) to obtain an intermediate material A; (3) mixing the intermediate material A obtained in step (2) with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain intermediate material B; (4) The intermediate material B obtained in step (3) is mixed with flavor to obtain a finished product.

[0013] Furthermore, the conditions in the mixing process in step (1) are: the stirring mixing time is 5 to 15 minutes, and the stirring speed is 20 to 25 r / min.

[0014] Furthermore, the conditions in the mixing process in step (2) are: the stirring mixing time is 5 to 15 minutes, and the stirring speed is 20 to 25 r / min.

[0015] Furthermore, the conditions in the mixing process in step (3) are: vacuum degree of -0.06 to -0.09 MPa, temperature of 35 to 50°C, stirring and mixing at a speed of 35 to 45 r / min for 20 to 30 min, and then high-speed dispersion at a speed of 960 r / min for 20 to 30 min.

[0016] Furthermore, the conditions in the mixing process in step (4) are: vacuum degree of -0.06 to -0.09 MPa, temperature controlled below 40°C, stirring and mixing at a speed of 35 to 45 r / min for 20 to 30 min, and then high-speed dispersion at a speed of 960 r / min for 20 to 30 min.

[0017] Compared with the prior art, this technical solution has the following beneficial effects: 1. The present invention adds banana fruit extract, mulberry bark extract, fennel extract, witch hazel extract and dactylophora extract in a specific ratio to the toothpaste formula. The compound use of these herbal components can improve the anti-inflammatory and fire-removing effect of the toothpaste paste, reduce the use of chemical drugs and antibiotics, and meet people's requirements for green and safe toothpaste. In addition, the present invention strictly controls the content of active ingredients in banana fruit extract, mulberry bark extract, fennel extract, witch hazel extract and dactylophora extract, ensuring that these herbal components can fully play their role after being compounded and added into the toothpaste, so that the toothpaste has a good anti-inflammatory effect.

[0018] 2. The toothpaste and herbal extract raw material preparation method of the present invention are simple to operate, highly controllable, and suitable for large-scale production of products with stable quality. DETAILED DESCRIPTION

[0019] The present invention is further described by the following examples, but is not intended to be limiting of the present invention. Specific experimental conditions and methods not specified in the following examples are conventional methods known to those skilled in the art.

[0020] Embodiment 1: An anti-inflammatory toothpaste, comprising the following raw material components in parts by weight: 0.2 parts of plantain fruit extract, 1.0 parts of mulberry bark extract, 0.1 parts of stephania tetrandra extract, 0.3 parts of witch hazel extract, 0.6 parts of scutellaria baicalensis extract, 40 parts of calcium carbonate, 4 parts of silicon dioxide, 4 parts of polyethylene glycol, 25 parts of sorbitol, 0.2 parts of methylparaben, 2.5 parts of sodium lauryl sulfate, 0.8 parts of sodium hydroxymethylcellulose, 0.3 parts of xanthan gum, 0.3 parts of benzyl alcohol, 0.3 parts of sodium saccharin, 0.1 parts of propylparaben, 1.0 parts of flavor, and 20 parts of water; The preparation method of the banana fruit extract is as follows: firstly, the banana fruit is crushed, then, it is extracted twice with 50% ethanol, the extracts are combined and concentrated under reduced pressure until there is no alcohol taste, then, it is left to stand overnight, then, the supernatant is passed through a macroporous adsorption resin, then, it is eluted with deionized water until it is colorless, then, impurities are eluted with 30% ethanol, finally, it is eluted with 75% ethanol and the eluate is collected, and the collected eluate is concentrated under reduced pressure and dried to obtain the banana fruit extract; The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the powder stephenci extract is to first crush the powder stephenci, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the powder stephenci extract; The preparation method of the witch hazel extract comprises the following steps: crushing the witch hazel, extracting the mixture twice with an extractant, combining the extracts and adding 70% ethanol to extract the mixture, obtaining a precipitate and a supernatant A, adding 80% ethanol to the precipitate for extraction twice, combining the supernatants to obtain a supernatant B, uniformly mixing the supernatant A and the supernatant B, and concentrating the mixture under reduced pressure until there is no alcohol taste, thereby obtaining the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1; The preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate them, then precipitate with 70% ethanol, filter and recover the ethanol solution and add water to precipitate, and filter and remove water to obtain the duckweed extract; The content of plantain fruit saponin in the plantain fruit extract is 22%; the content of solids in the mulberry bark extract is 3%; the content of tetrandrin in the stephencirias extract is 0.6%; the content of tannin in the witch hazel extract is 5.2 mg / kg; the content of extract in the scutellaria extract is 21%; The preparation method of the anti-inflammatory toothpaste described in this embodiment comprises the following steps: (1) Weighing raw material components according to proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogonis extract, saccharin sodium and water to obtain a premix; the mixing process is carried out under the conditions of: stirring mixing time of 10 minutes and stirring speed of 22 r / min; (2) Mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, sorbitol and the premix obtained in step (1) to obtain an intermediate material A; the conditions in the mixing process are: stirring mixing time is 10 minutes, and stirring speed is 22 r / min; (3) The intermediate material A obtained in step (2) is mixed with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain an intermediate material B; the conditions in the mixing process are: vacuum degree of -0.08 MPa, temperature of 40°C, stirring and mixing at a speed of 40 r / min for 25 min, and then high-speed dispersion at a speed of 960 r / min for 25 min; (4) The intermediate material B obtained in step (3) is mixed with the essence to obtain a finished product; the conditions in the mixing process are: vacuum degree is -0.08 MPa, temperature is controlled at 35°C, stirring and mixing is first performed at a speed of 40 r / min for 25 min, and then high-speed dispersion is performed at a speed of 960 r / min for 25 min.

[0021] Embodiment 2: An anti-inflammatory toothpaste, comprising the following raw material components in parts by weight: 0.05 parts of plantain fruit extract, 0.1 parts of mulberry bark extract, 0.01 parts of ground wormwood extract, 0.1 parts of witch hazel extract, 0.1 parts of scutellaria baicalensis extract, 35 parts of calcium carbonate, 2 parts of silicon dioxide, 2 parts of polyethylene glycol, 20 parts of sorbitol, 0.2 parts of methylparaben, 0.5 parts of sodium lauryl sulfate, 0.5 parts of sodium hydroxymethylcellulose, 0.1 parts of xanthan gum, 0.1 parts of benzyl alcohol, 0.2 parts of sodium saccharin, 0.1 parts of propylparaben, 0.8 parts of flavor, and 15 parts of water; The preparation method of the banana fruit extract is as follows: firstly, the banana fruit is crushed, then, it is extracted twice with 50% ethanol, the extracts are combined and concentrated under reduced pressure until there is no alcohol taste, then, it is left to stand overnight, then, the supernatant is passed through a macroporous adsorption resin, then, it is eluted with deionized water until it is colorless, then, impurities are eluted with 20% ethanol, finally, it is eluted with 60% ethanol and the eluate is collected, and the collected eluate is concentrated under reduced pressure and dried to obtain the banana fruit extract; The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the powder stephenci extract is to first crush the powder stephenci, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the powder stephenci extract; The preparation method of the witch hazel extract comprises the following steps: crushing the witch hazel, extracting the mixture twice with an extractant, combining the extracts and adding 70% ethanol to extract the mixture, obtaining a precipitate and a supernatant A, adding 80% ethanol to the precipitate for extraction twice, combining the supernatants to obtain a supernatant B, uniformly mixing the supernatant A and the supernatant B, and concentrating the mixture under reduced pressure until there is no alcohol taste, thereby obtaining the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1; The preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate them, then precipitate with 70% ethanol, filter and recover the ethanol solution and add water to precipitate, and filter and remove water to obtain the duckweed extract; The content of plantain fruit saponin in the plantain fruit extract is 20%; the content of solids in the mulberry bark extract is 2%; the content of tetrandrin in the stephencirias extract is 0.5%; the content of tannin in the witch hazel extract is 4.3 mg / kg; the content of extract in the scutellaria extract is 20%; The preparation method of the anti-inflammatory toothpaste described in this embodiment comprises the following steps: (1) Weighing raw material components in proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogon japonicus extract, saccharin sodium and water to obtain a premix; the mixing process is carried out under the conditions of: stirring mixing time of 5 minutes and stirring speed of 25 r / min; (2) Mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, sorbitol and the premix obtained in step (1) to obtain an intermediate material A; the conditions in the mixing process are: stirring mixing time is 5 minutes, and stirring speed is 25 r / min; (3) The intermediate material A obtained in step (2) is mixed with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain an intermediate material B; the conditions in the mixing process are: vacuum degree of -0.06 MPa, temperature of 50°C, stirring and mixing at a speed of 45 r / min for 20 min, and then high-speed dispersion at a speed of 960 r / min for 20 min; (4) The intermediate material B obtained in step (3) is mixed with the essence to obtain a finished product; the conditions in the mixing process are: vacuum degree of -0.06 MPa, temperature of 40°C, stirring and mixing at a speed of 45 r / min for 20 min, and then high-speed dispersion at a speed of 960 r / min for 20 min.

[0022] Embodiment 3: An anti-inflammatory toothpaste, comprising the following raw material components in parts by weight: 0.4 parts of plantain fruit extract, 1.5 parts of mulberry bark extract, 0.15 parts of stephania tetrandra extract, 0.35 parts of witch hazel extract, 0.8 parts of euphorbia pulegosa extract, 42 parts of calcium carbonate, 4 parts of silicon dioxide, 3 parts of polyethylene glycol, 25 parts of sorbitan, 0.25 parts of methylparaben, 0.6 parts of sodium lauryl sulfate, 0.6 parts of sodium hydroxymethylcellulose, 0.3 parts of xanthan gum, 0.15 parts of benzyl alcohol, 0.3 parts of sodium saccharin, 0.12 parts of propylparaben, 0.9 parts of flavor, and 23 parts of water; The preparation method of the banana fruit extract is as follows: firstly, the banana fruit is crushed, then, it is extracted twice with 50% ethanol, the extracts are combined and concentrated under reduced pressure until there is no alcohol taste, then, it is left to stand overnight, then, the supernatant is passed through a macroporous adsorption resin, then, it is eluted with deionized water until it is colorless, then, impurities are eluted with 30% ethanol, finally, it is eluted with 75% ethanol and the eluate is collected, and the collected eluate is concentrated under reduced pressure and dried to obtain the banana fruit extract; The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the powder stephenci extract is to first crush the powder stephenci, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the powder stephenci extract; The preparation method of the witch hazel extract comprises the following steps: crushing the witch hazel, extracting the mixture twice with an extractant, combining the extracts and adding 70% ethanol to extract the mixture, obtaining a precipitate and a supernatant A, adding 80% ethanol to the precipitate for extraction twice, combining the supernatants to obtain a supernatant B, uniformly mixing the supernatant A and the supernatant B, and concentrating the mixture under reduced pressure until there is no alcohol taste, thereby obtaining the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1; The preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate them, then precipitate with 70% ethanol, filter and recover the ethanol solution and add water to precipitate, and filter and remove water to obtain the duckweed extract; The content of plantain fruit saponin in the plantain fruit extract is 21%; the content of solids in the mulberry bark extract is 2.8%; the content of tetrandrin in the stephencirias extract is 0.6%; the content of tannin in the witch hazel extract is 4.9 mg / kg; the content of extract in the scutellaria extract is 21%; The preparation method of the anti-inflammatory toothpaste described in this embodiment comprises the following steps: (1) Weighing raw material components in proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogon japonicus extract, sodium saccharin and water to obtain a premix; the mixing process is carried out under the conditions of: stirring mixing time of 10 minutes and stirring speed of 25 r / min; (2) Mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, sorbitol and the premix obtained in step (1) to obtain an intermediate material A; the conditions in the mixing process are: stirring mixing time is 10 minutes, and stirring speed is 25 r / min; (3) The intermediate material A obtained in step (2) is mixed with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain an intermediate material B; the conditions in the mixing process are: vacuum degree of -0.07 MPa, temperature of 48°C, stirring and mixing at a speed of 40 r / min for 25 min, and then high-speed dispersion at a speed of 960 r / min for 25 min; (4) The intermediate material B obtained in step (3) is mixed with the essence to obtain a finished product; the conditions in the mixing process are: vacuum degree of -0.07 MPa, temperature of 30°C, stirring and mixing at a speed of 40 r / min for 25 min, and then high-speed dispersion at a speed of 960 r / min for 25 min.

[0023] Embodiment 4: An anti-inflammatory toothpaste, comprising the following raw material components in parts by weight: 0.5 parts of plantain fruit extract, 2.0 parts of mulberry bark extract, 0.2 parts of stephania tetrandra extract, 0.5 parts of witch hazel extract, 1 part of scutellaria baicalensis extract, 45 parts of calcium carbonate, 8 parts of silicon dioxide, 5 parts of polyethylene glycol, 30 parts of sorbitol, 0.5 parts of methylparaben, 0.8 parts of sodium lauryl sulfate, 0.8 parts of sodium hydroxymethylcellulose, 0.4 parts of xanthan gum, 0.5 parts of benzyl alcohol, 0.5 parts of sodium saccharin, 0.2 parts of propylparaben, 1.2 parts of flavor, and 25 parts of water; The preparation method of the banana fruit extract is as follows: firstly, the banana fruit is crushed, then, it is extracted twice with 50% ethanol, the extracts are combined and concentrated under reduced pressure until there is no alcohol taste, then, it is left to stand overnight, then, the supernatant is passed through a macroporous adsorption resin, then, it is eluted with deionized water until it is colorless, then, impurities are eluted with 40% ethanol, finally, it is eluted with 80% ethanol and the eluate is collected, and the collected eluate is concentrated under reduced pressure and dried to obtain the banana fruit extract; The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the powder stephenci extract is to first crush the powder stephenci, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the powder stephenci extract; The preparation method of the witch hazel extract is as follows: crush the witch hazel, then extract it twice with an extractant, combine the extracts and add 70% ethanol to extract, obtain a precipitate and a supernatant A, then add 80% ethanol to the precipitate for extraction twice, combine the supernatants to obtain a supernatant B, evenly mix the supernatant A and the supernatant B, and then concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1; the preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate, then precipitate with 70% ethanol, filter and recover the ethanol solution, add water to precipitate, and filter and remove water to obtain the duckweed extract; The content of plantain fruit saponin in the plantain fruit extract is 21%; the content of solids in the mulberry bark extract is 2.3%; the content of tetrandrin in the stephencirias extract is 0.52%; the content of tannin in the witch hazel extract is 4.3 mg / kg; the content of extract in the scutellaria extract is 22%; The preparation method of the anti-inflammatory toothpaste described in this embodiment comprises the following steps: (1) Weighing raw material components in proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogon japonicus extract, saccharin sodium and water to obtain a premix; the mixing process is carried out under the conditions of: stirring mixing time of 15 minutes and stirring speed of 20 r / min; (2) Mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, sorbitol and the premix obtained in step (1) to obtain an intermediate material A; the conditions in the mixing process are: stirring mixing time is 15 minutes, and stirring speed is 20 r / min; (3) The intermediate material A obtained in step (2) is mixed with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain an intermediate material B; the conditions in the mixing process are: vacuum degree of -0.09 MPa, temperature of 35°C, stirring and mixing at a speed of 35 r / min for 30 min, and then high-speed dispersion at a speed of 960 r / min for 30 min; (4) The intermediate material B obtained in step (3) is mixed with the essence to obtain a finished product; the conditions in the mixing process are: vacuum degree of -0.09 MPa, temperature of 30°C, stirring and mixing at a speed of 35 r / min for 30 min, and then high-speed dispersion at a speed of 960 r / min for 30 min.

[0024] Comparative Example 1: The anti-inflammatory toothpaste described in this comparative example is different from the toothpaste described in Example 1 only in that the anti-inflammatory toothpaste does not include Stephania tetrandra extract and Hamamelis virginiana extract, and the preparation method is the same as the preparation method described in Example 1.

[0025] Comparative Example 2: The anti-inflammatory toothpaste described in this comparative example is different from the toothpaste described in Example 1 only in that the anti-inflammatory toothpaste does not include plantain fruit extract and witch hazel extract, and the preparation method is the same as the preparation method described in Example 1.

[0026] Comparative Example 3: The anti-inflammatory toothpaste described in this comparative example is different from the toothpaste described in Example 1 only in that the anti-inflammatory toothpaste does not include Dactylum japonica extract and Hamamelis virginiana extract, and the preparation method is the same as the preparation method described in Example 1.

[0027] Comparative Example 4: The anti-inflammatory toothpaste described in this comparative example is different from the toothpaste described in Example 1 only in that the anti-inflammatory toothpaste does not include the Dactylum japonicum extract, and the preparation method is the same as the preparation method described in Example 1.

[0028] Comparative Example 5: The anti-inflammatory toothpaste described in this comparative example is different from the toothpaste described in Example 1 only in that, in the anti-inflammatory toothpaste, the content of plantain fruit saponin in the plantain fruit extract is 19%; the content of solids in the mulberry bark extract is 2.2%; the content of tetrandrin in the stephania tetrandra extract is 0.45%; the content of tannin in the witch hazel extract is 4.0 mg / kg; the content of extract in the ophiopogonis extract is 18%, and the preparation method is the same as the preparation method described in Example 1.

[0029] Comparative Example 6: The only difference between the anti-inflammatory toothpaste described in this comparative example and the toothpaste described in Example 1 is that in the anti-inflammatory toothpaste, the content of plantain fruit saponin in the plantain fruit extract is 20%; the content of solids in the mulberry bark extract is 1.9%; the content of tetrandrin in the stephania tetrandra extract is 0.55%; the content of tannin in the witch hazel extract is 3.9 mg / kg; the content of extract in the ophiopogonis extract is 18%, and the preparation method is the same as the preparation method described in Example 1.

[0030] Comparative Example 7: The only difference between the anti-inflammatory toothpaste described in this comparative example and the toothpaste described in Example 1 is that in the anti-inflammatory toothpaste, the content of plantain fruit saponin in the plantain fruit extract is 22%; the content of solids in the mulberry bark extract is 2.5%; the content of tetrandrin in the stephania tetrandra extract is 0.5%; the content of tannin in the witch hazel extract is 4.0 mg / kg; the content of extract in the ophiopogonis extract is 18%, and the preparation method is the same as the preparation method described in Example 1.

[0031] Experimental example: Anti-inflammatory toothpaste was prepared according to the preparation method described in Examples 1 to 4 and Comparative Examples 1 to 7, and the anti-inflammatory effect was tested on them. First, the prepared anti-inflammatory toothpaste was tested on mice, wherein the experimental animals and the breeding environment were SPF-grade KM mice, male, 18 to 22 g, provided by the Guangdong Medical Experimental Animal Center, with an experimental animal production license of SCXK (Guangdong) 2018-0002, quality certificate number: N0.44007200098195, and feed was provided by the Guangdong Medical Experimental Animal Center; the animals were raised in a barrier environment animal room after purchase and used after passing the quarantine, with an experimental animal use license number of SYXK (Guangdong) 8018-0137; the temperature of the animal room was 20°C to 26°C, and the humidity was 40% to 70%; instruments and reagents were prepared at the same time, the main instruments included a Sartorius electronic balance and a puncher, and the reagents included xylene; The test method specifically includes the following steps: (1) SPF KM mice that passed the quarantine were randomly divided into two groups, 12 mice in each group, namely the test substance group and the model control group; (2) After the mice were quarantined and grouped, the left ear was left untreated as the background value, and 30 μL of xylene solution was applied to both sides of the right ear (the model control group was not treated). 30 minutes later, 0.1 g of the tested anti-inflammatory toothpaste was applied to both sides of the right ear of the mice in the test group. One hour after the application, the mice were killed by cervical dislocation and the test substance was wiped off. Both ears were cut off, and the ear pieces with a diameter of 8 mm (the same part of the left and right ears) were weighed and recorded. The weight difference between the left and right ears of the same animal was the swelling degree. Swelling degree = weight of right ear piece - weight of left ear piece; Swelling inhibition rate = (average swelling degree of model control group - average swelling degree of test substance group) / average swelling degree of model control group × 100%; (3) Statistical analysis: The experimental data were expressed as mean ± standard deviation (±S), and the independent sample T test was performed using SPSS software. The inhibitory effects of the experimental results compared with those of the model control group are shown in Table 1.

[0032] Table 1 Test results of anti-inflammatory toothpaste prepared by different preparation methods

[0033] It can be seen from the data in Table 1 that the ear swelling of the mice in the test group using the toothpaste prepared by the method of the present invention was significantly reduced, and the difference was statistically significant (P<0.05), indicating that the toothpaste of the present invention has a good anti-inflammatory and heat-removing effect.

[0034] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. An anti-inflammatory toothpaste, characterized in that: The invention comprises the following raw material components in parts by weight: 0.05-0.5 parts of plantain fruit extract, 0.1-2.0 parts of mulberry bark extract, 0.01-0.2 parts of stephania tetrandra extract, 0.1-0.5 parts of witch hazel extract, 0.1-1 parts of euphorbia pulegosa extract, 35-45 parts of calcium carbonate, 2-8 parts of silicon dioxide, 2-5 parts of polyethylene glycol, 20-30 parts of sorbitol, 0.2-0.5 parts of methylparaben, 0.5-0.8 parts of sodium lauryl sulfate, 0.5-0.8 parts of sodium hydroxymethylcellulose, 0.1-0.4 parts of xanthan gum, 0.1-0.5 parts of benzyl alcohol, 0.2-0.5 parts of sodium saccharin, 0.1-0.2 parts of propylparaben, 0.8-1.2 parts of flavor and 15-25 parts of water.

2. The anti-inflammatory toothpaste according to claim 1, characterized in that: The preparation method of the banana fruit extract is as follows: firstly, the banana fruit is crushed, then, it is extracted twice with 50% ethanol, the extracts are combined and concentrated under reduced pressure until there is no alcohol taste, then, it is left to stand overnight, then, the supernatant is passed through a macroporous adsorption resin, then, it is eluted with deionized water until it is colorless, then, impurities are eluted with ethanol with a concentration of 20% to 40%, finally, it is eluted with ethanol with a concentration of 60 to 80%, and the eluate is collected, and the collected eluate is concentrated under reduced pressure and dried to obtain the banana fruit extract; The preparation method of the mulberry bark extract comprises the following steps: crushing the mulberry bark, extracting it with water twice, combining the extracts and concentrating them, precipitating them with 95% ethanol, filtering and recovering the ethanol solution, adding water for precipitation, filtering and removing water to obtain the mulberry bark extract; The preparation method of the powder stephenci extract is to first crush the powder stephenci, then extract it twice with 70% ethanol, combine the extracts and concentrate them under reduced pressure until there is no alcohol taste, so as to obtain the powder stephenci extract; The preparation method of the witch hazel extract comprises the following steps: crushing the witch hazel, extracting the mixture twice with an extractant, combining the extracts and adding 70% ethanol to extract the mixture, obtaining a precipitate and a supernatant A, adding 80% ethanol to the precipitate for extraction twice, combining the supernatants to obtain a supernatant B, uniformly mixing the supernatant A and the supernatant B, and concentrating the mixture under reduced pressure until there is no alcohol taste, thereby obtaining the witch hazel extract; the extractant is obtained by mixing water and boric acid, and the mass ratio of water to boric acid is 100:1; The preparation method of the duckweed extract is to extract the duckweed twice with water, combine the extracts and concentrate them, then precipitate with 70% ethanol, filter and recover the ethanol solution and add water to precipitate, and filter and remove water to obtain the duckweed extract.

3. The anti-inflammatory toothpaste according to claim 1, characterized in that: The content of plantain fruit saponin in the plantain fruit extract is ≥20%; the content of solids in the mulberry bark extract is ≥2%; the content of tetrandrin in the stephencirias extract is ≥0.5%; the content of tannin in the witch hazel extract is ≥4.3 mg / kg; and the content of extract in the ophiopogonis extract is ≥20%.

4. The anti-inflammatory toothpaste according to claim 1, characterized in that: The anti-inflammatory toothpaste comprises the following raw material components in parts by weight: 40 parts of calcium carbonate, 4 parts of silicon dioxide, 4 parts of polyethylene glycol, 25 parts of sorbitol, 0.2 parts of methylparaben, 2.5 parts of sodium lauryl sulfate, 0.8 parts of sodium hydroxymethylcellulose, 0.3 parts of xanthan gum, 0.3 parts of benzyl alcohol, 0.3 parts of sodium saccharin, 0.1 parts of propylparaben, 1.0 parts of flavor and 20 parts of water.

5. The method for preparing the anti-inflammatory toothpaste according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) weighing raw material components according to proportion, and then mixing plantain fruit extract, mulberry bark extract, Stephania tetrandra extract, witch hazel extract, ophiopogonis extract, saccharin sodium and water to obtain a premix; (2) mixing polyethylene glycol, benzyl alcohol, methylparaben, propylparaben, and sorbitol with the premix obtained in step (1) to obtain an intermediate material A; (3) mixing the intermediate material A obtained in step (2) with calcium carbonate, silicon dioxide, sodium lauryl sulfate, sodium hydroxymethyl cellulose and xanthan gum to obtain intermediate material B; (4) The intermediate material B obtained in step (3) is mixed with flavor to obtain a finished product.

6. The method for preparing the anti-inflammatory toothpaste according to claim 5, characterized in that: The conditions in the mixing process in step (1) are: stirring mixing time is 5 to 15 minutes, and stirring speed is 20 to 25 r / min.

7. The method for preparing the anti-inflammatory toothpaste according to claim 5, characterized in that: The conditions in the mixing process in step (2) are: stirring mixing time is 5 to 15 minutes, and stirring speed is 20 to 25 r / min.

8. The method for preparing the anti-inflammatory toothpaste according to claim 5, characterized in that: The conditions in the mixing process in step (3) are: vacuum degree of -0.06 to -0.09 MPa, temperature of 35 to 50°C, stirring and mixing at a speed of 35 to 45 r / min for 20 to 30 min, and then high-speed dispersion at a speed of 960 r / min for 20 to 30 min.

9. The method for preparing the anti-inflammatory toothpaste according to claim 5, characterized in that: The conditions in the mixing process in step (4) are: vacuum degree of -0.06 to -0.09 MPa, temperature controlled below 40°C, stirring and mixing at a speed of 35 to 45 r / min for 20 to 30 min, and then high-speed dispersion at a speed of 960 r / min for 20 to 30 min.

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