Preparation process of compound cacumen biotae cream for improving alopecia
By using the combination of active ingredient extracts and cream ingredients in Orchidaceae leaves, dried ginger and erectile dysfunction, the problem of major side effects of existing drugs for treating hair loss is solved, and a kind of natural ingredients, low toxicity and good therapeutic effect is prepared. Hair growth creams have achieved the effect of improving hair loss and promoting hair growth.
Patent Information
- Application Number
- CN202411469309.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-21
- Publication Date
- 2025-02-07
AI Technical Summary
The existing drugs for treating hair loss have greater side effects, while natural plant-based drugs are low in toxicity and have good results. There is a lack of a natural hair-growth cream preparation method that can effectively improve hair loss.
Use active ingredient extracts from Orchidaceae leaves, dried ginger and erectile syrup, combined with white petroleum, stearic acid, glyceryl monostearate, liquid paraffin, glycerol, polyoxyethylene sorbitol monooleate and deionized Compound creams are prepared by ultrasonic extraction, extraction and rotary evaporation.
It improves the content of active ingredients in hair growth products, has anti-inflammatory, antibacterial, antioxidant, and blood circulation effects, improves scalp condition, relieves itching, promotes hair growth and development, and prevents hair loss. The product is stable and easy to use.
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of preparation of hair growth creams, and more specifically discloses a preparation method of a compound Platycladus orientalis leaf cream for improving hair loss. Background Art
[0002] Hair loss is medically defined as abnormal hair loss caused by factors such as genetics, immunity, stress, taking certain drugs, and endocrine disorders. It is a common clinical skin disease in modern society. Although it does not threaten human life, it brings great psychological anxiety and mental pressure to patients. Hair problems have received widespread attention, so the development of a hair growth product has a good market prospect. Existing therapeutic drugs have large side effects, while natural plant-based drugs are low in toxicity and have good effects. The extract of Platycladus orientalis leaves in the Compendium of Materia Medica can promote local blood circulation and enhance the metabolic function of hair follicles. Dried ginger and Eclipta prostrata have the effects of nourishing the liver and kidneys, nourishing blood, and preventing hair loss.
[0003] Creams have good stability and adhere to the application site, which can greatly improve drug utilization and efficacy. By utilizing the medicinal ingredients of Platycladus orientalis leaves, dried ginger, and Eclipta prostrata to develop a hair growth cream, a new option is provided for patients with hair loss.
[0004] Therefore, developing a preparation method for a compound Platycladus orientalis leaf ointment for improving hair loss is a technical problem that current researchers need to overcome. Summary of the invention
[0005] In view of this, the present invention provides a method for preparing a compound Platycladus orientalis leaf ointment for improving hair loss.
[0006] In order to achieve the above object, the present invention adopts the following technical solution: The invention provides a compound Platycladus orientalis leaf cream for improving hair loss. The cream is prepared from the following raw materials in parts by weight: 3-5 parts by weight of active ingredient extracts of Platycladus orientalis leaves, dried ginger and Eclipta prostrata, an oil phase comprising 3-5 parts by weight of white vaseline, 6 parts by weight of stearic acid, 7-12 parts by weight of glyceryl monostearate, 7-12 parts by weight of liquid paraffin, an aqueous phase comprising 12 parts by weight of glycerol, 3-5 parts by weight of polyoxyethylene sorbitan monooleate, 47-52 parts by weight of deionized water and 2 parts by weight of natural pigment.
[0007] Furthermore, the above-mentioned compound Platycladus orientalis leaf cream for improving hair loss is prepared from the following raw materials in parts by weight: 4 parts by weight of active ingredient extracts from Platycladus orientalis leaves, dried ginger, and Eclipta prostrata, an oil phase including 5 parts by weight of white vaseline, 6 parts by weight of stearic acid, 9 parts by weight of glyceryl monostearate, 9 parts by weight of liquid paraffin, an aqueous phase including 12 parts by weight of glycerol, 5 parts by weight of polyoxyethylene sorbitan monooleate, and 50 parts by weight of deionized water.
[0008] The present invention also provides a method for preparing a compound Platycladus orientalis leaf cream for improving hair loss, comprising the following steps: weighing an oil phase, including white vaseline, stearic acid, glyceryl monostearate, and liquid paraffin, heating the weighed oil phase in a water bath to completely dissolve it and maintain the temperature; adding weighed active ingredient extracts of Platycladus orientalis leaves, dried ginger, and Eclipta prostrata to the oil phase, and stirring to mix evenly; weighing an aqueous phase in a beaker, including glycerol, polyoxyethylene sorbitan monooleate, deionized water, and natural pigments, heating the weighed aqueous phase in a water bath and stirring evenly, using a magnetic stirrer in the aqueous phase, and adding the oil phase dropwise to the aqueous phase and stirring evenly; taking out the beaker, stirring it at a uniform speed with a glass rod to make it into a creamy state, and naturally cooling it to room temperature to obtain the ointment.
[0009] Furthermore, the preparation method of the active ingredient extracts from the above-mentioned Platycladus orientalis leaves, dried ginger, and Eclipta prostrata comprises the following steps: (1) Weigh Platycladus orientalis leaves, dried ginger, and Eclipta prostrata, grind each into powder, and mix them. Add ethanol to the mixture at a specific material-liquid ratio, extract under ultrasound, filter the residue, repeat the process, and combine the extracts. (2) further filtering the extract using a filtration device to obtain a filtrate; (3) Using a rotary evaporator, the filtrate is evaporated to an extract, extracted with ethyl acetate, and the upper layer is taken and the operation is repeated to obtain an ethyl acetate extract; (4) The ethyl acetate extract was rotary evaporated into an extract using a rotary evaporator to obtain an extract of the active ingredients in Platycladus orientalis leaves, dried ginger, and Eclipta prostrata.
[0010] Furthermore, in step (1), the ratio of the Platycladus orientalis leaves, dried ginger and Eclipta prostrata is 2:1:1, the solid-liquid ratio is 1:10, the ethanol concentration is 70%, the ultrasonic extraction power is 400 W, the extraction time is 1 h, and the operation is repeated once.
[0011] Furthermore, in step (3), the temperature of the rotary evaporation is 60-70° C., the extraction time is 20 min, and the operation is repeated 3 times.
[0012] Furthermore, the rotary evaporation temperature in step (4) is 35-45°C.
[0013] Furthermore, the temperature of the oil phase water bath heating is 80°C.
[0014] Furthermore, the water phase is heated in a water bath at a temperature of 80°C.
[0015] Furthermore, the rotation speed of the magnetic stirrer is 1000 rpm, and the stirring time is 30 min.
[0016] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. As a natural plant-based hair growth product, the present invention has good anti-inflammatory, antibacterial, antioxidant, blood circulation effects, and the effects of promoting hair growth and development and preventing hair loss.
[0017] 2. The present invention can increase the content of active ingredients of plant components in the hair growth product by adding powders of Platycladus orientalis leaves, dried ginger and Eclipta prostrata to a specific solvent in proportion, and performing a series of steps including ultrasonic extraction, extraction and rotary evaporation.
[0018] 3. The active ingredient extracts of Platycladus orientalis leaves, dried ginger and Eclipta prostrata in the present invention can improve scalp conditions, relieve itching, promote scalp blood circulation, stimulate hair growth and other effects.
[0019] 4. As a hair growth cream product, the present invention is easy to use, adheres to the medication site, is easy to spread and absorb, greatly improves the drug utilization rate, and the raw material source is natural and safe, without side effects. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] Figure 1 Illustration of creams made with six different formulation ratios; Figure 2 Illustration of the cream centrifugation test; Figure 3 Illustration of the cream cold resistance test; Figure 4 Illustration of the heat resistance test of cream; Figure 5 Comprehensive sensory scores of each formulation. DETAILED DESCRIPTION
[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0022] Preparation method of active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata: (1) Weigh Platycladus orientalis leaves, dried ginger, and Eclipta prostrata in a ratio of 2:1:1, grind each into powder and mix them, add 70% ethanol to the mixture at a solid-liquid ratio of 1:10, and perform ultrasonic extraction at a power of 400 W for 1 h. Filter the residue, repeat the operation once, and combine the extracts; (2) further filtering the extract using a filtration device to obtain a filtrate; (3) Using a rotary evaporator, evaporate the filtrate at 60-70°C to obtain an extract, extract with ethyl acetate for 20 min, take the upper layer, and repeat the operation three times to obtain an ethyl acetate extract; (4) Using a rotary evaporator, the ethyl acetate extract was rotary evaporated to an extract at a temperature of 35-45°C to obtain an extract of active ingredients from Platycladus orientalis leaves, dried ginger, and Eclipta prostrata.
[0023] Six formulations were developed according to the ratios. The oil phase was weighed according to the formula, including white vaseline, stearic acid, glyceryl monostearate, and liquid paraffin. The weighed oil phase was heated to 80°C in a water bath to dissolve completely and maintain the temperature. The weighed active ingredient extracts of Platycladus orientalis leaves, dried ginger, and Eclipta prostrata were added to the oil phase, and stirred to mix evenly. The water phase was weighed in a beaker, including glycerol, polyoxyethylene sorbitan monooleate, deionized water, and natural pigments. The weighed water phase was heated to 80°C in a water bath and stirred evenly. A magnetic stirrer was used in the water phase at 1000 rpm, and the oil phase was added dropwise to the water phase and stirred for 30 minutes. The beaker was taken out and stirred at a uniform speed with a glass rod to make it into a cream, which was naturally cooled to room temperature. The specific formulation ratios are shown in Table 1.
[0024] Table 1 Proportions of six formulations of Platycladus orientalis, dried ginger, and Eclipta prostrata creams.
[0025] name Recipe 1 (servings) Recipe 2 (servings) Recipe 3 (servings) Recipe 4 (servings) Recipe 5 (servings) Recipe 6 (servings) Extracts 3 4 5 3 4 5 White Vaseline 5 5 5 3 3 3 Stearic acid 6 6 6 6 6 6 Glyceryl Monostearate 11 9 7 8 10 12 Liquid paraffin 7 9 11 12 10 8 glycerin 12 12 12 12 12 12 Polyoxyethylene sorbitan monooleate 5 5 5 3 3 3 Deionized water 49 50 47 51 52 49 natural pigments 2 0 2 2 0 2 Gardenia Blue none Algae blue Cochineal none <![CDATA[VB 12 ]]>
[0026] Example 1 The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 3 parts, white vaseline was 5 parts, stearic acid was 6 parts, glyceryl monostearate was 11 parts, liquid paraffin was 7 parts, glycerol was 12 parts, polyoxyethylene sorbitan monooleate was 5 parts, deionized water was 49 parts, and gardenia blue pigment was 2 parts. The cream was prepared according to the above steps. Example
[0027] The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 4 parts, white vaseline was added in an amount of 5 parts, stearic acid was added in an amount of 6 parts, glyceryl monostearate was added in an amount of 9 parts, liquid paraffin was added in an amount of 9 parts, glycerol was added in an amount of 12 parts, polyoxyethylene sorbitan monooleate was added in an amount of 5 parts and deionized water was added in an amount of 50 parts, and a cream was prepared according to the above steps. Example
[0028] The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 5 parts, white vaseline was 5 parts, stearic acid was 6 parts, glyceryl monostearate was 7 parts, liquid paraffin was 11 parts, glycerol was 12 parts, polyoxyethylene sorbitan monooleate was 5 parts, deionized water was 47 parts, and phycocyanin was 2 parts. A cream was prepared according to the above steps. Example
[0029] The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 3 parts, white vaseline was 3 parts, stearic acid was 6 parts, glyceryl monostearate was 8 parts, liquid paraffin was 12 parts, glycerol was 12 parts, polyoxyethylene sorbitan monooleate was 3 parts, deionized water was 51 parts, and cochineal red pigment was 2 parts. A cream was prepared according to the above steps. Example
[0030] The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 4 parts, white vaseline was added in an amount of 3 parts, stearic acid was added in an amount of 6 parts, glyceryl monostearate was added in an amount of 10 parts, liquid paraffin was added in an amount of 10 parts, glycerol was added in an amount of 12 parts, polyoxyethylene sorbitan monooleate was added in an amount of 3 parts and deionized water was added in an amount of 52 parts, and a cream was prepared according to the above steps.
[0031] Example 6 The active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata were added in an amount of 5 parts, white vaseline was 3 parts, stearic acid was 6 parts, glyceryl monostearate was 12 parts, liquid paraffin was 8 parts, glycerol was 12 parts, polyoxyethylene sorbitan monooleate was 3 parts, deionized water was 49 parts, and VB12 pigment was 2 parts. The cream was prepared according to the above steps.
[0032] 30 evaluation members were invited to evaluate the importance of evaluation indicators such as color, smell, texture and stability in the cream evaluation criteria, and the weight set C = (0.2, 0.3, 0.3, 0.2) was obtained from the importance of the evaluation indicators, and the total weight was 1.
[0033] In order to obtain the best formula, 30 subjects evaluated the creams prepared in Examples 1-6 in terms of color, smell, texture, and stability by scoring. The specific details are shown in Table 2.
[0034] Table 2 Sensory scoring criteria for creams.
[0035]
[0036] The experimental results are as follows Figure 1 As shown: According to the analysis of the experimental results, the optimal proportion of the cream formula of the present invention is 4 parts of active ingredient extracts from Platycladus orientalis leaves, dried ginger, and Eclipta prostrata, 5 parts of white vaseline, 6 parts of stearic acid, 9 parts of glyceryl monostearate, 9 parts of liquid paraffin, 12 parts of glycerol, 5 parts of polyoxyethylene sorbitan monooleate, and 50 parts of deionized water. The cream prepared by the present invention has good stability, is not easy to separate oil and water, has good texture, is easy to spread and absorb, is easy to store, and has good use effect.
[0037] The disclosed embodiments are described to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A compound Platycladus orientalis leaf cream for improving hair loss, characterized in that: The invention is prepared from the following raw materials in parts by weight: 3-5 parts by weight of active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata, an oil phase comprising 3-5 parts by weight of white vaseline, 6 parts by weight of stearic acid, 7-12 parts by weight of glyceryl monostearate, 7-12 parts by weight of liquid paraffin, an aqueous phase comprising 12 parts by weight of glycerol, 3-5 parts by weight of polyoxyethylene sorbitan monooleate, 47-52 parts by weight of deionized water and 2 parts by weight of natural pigment.
2. A compound Platycladus orientalis leaf cream for improving hair loss according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 4 parts by weight of active ingredient extracts from Platycladus orientalis leaves, dried ginger and Eclipta prostrata, an oil phase comprising 5 parts by weight of white vaseline, 6 parts by weight of stearic acid, 9 parts by weight of glyceryl monostearate, 9 parts by weight of liquid paraffin, and an aqueous phase comprising 12 parts by weight of glycerol, 5 parts by weight of polyoxyethylene sorbitan monooleate and 50 parts by weight of deionized water.
3. A method for preparing a compound Platycladus orientalis leaf ointment for improving hair loss according to claim 2, characterized in that: The following steps are involved: The method comprises the following steps: weighing an oil phase, including white vaseline, stearic acid, monostearate glyceryl, and liquid paraffin, heating the weighed oil phase in a water bath to completely dissolve the oil phase and maintaining the temperature; adding weighed active ingredient extracts of Platycladus orientalis leaves, dried ginger, and Eclipta prostrata to the oil phase, and stirring the mixture to make the mixture uniform; weighing an aqueous phase, including glycerin, polyoxyethylene sorbitan monooleate, deionized water, and natural pigment in a beaker, heating the weighed aqueous phase in a water bath and stirring the mixture to make the mixture uniform; using a magnetic stirrer in the aqueous phase, and adding the oil phase dropwise to the aqueous phase and stirring the mixture to make the mixture uniform; taking out the beaker, stirring the mixture at a uniform speed with a glass rod to make it into a creamy paste, and naturally cooling the mixture to room temperature to obtain the product.
4. A method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 3, characterized in that: The method for preparing the active ingredient extract from Platycladus orientalis leaves, dried ginger and Eclipta prostrata comprises the following steps: (1) Weigh Platycladus orientalis leaves, dried ginger, and Eclipta prostrata, grind each into powder, and mix them. Add ethanol to the mixture at a specific material-liquid ratio, extract under ultrasound, filter the residue, repeat the operation, and combine the extracts. (2) further filtering the extract using a filtration device to obtain a filtrate; (3) Using a rotary evaporator, the filtrate is evaporated to an extract, extracted with ethyl acetate, and the upper layer is taken and the operation is repeated to obtain an ethyl acetate extract; (4) The ethyl acetate extract was rotary evaporated into an extract using a rotary evaporator to obtain an extract of the active ingredients in Platycladus orientalis leaves, dried ginger, and Eclipta prostrata.
5. A method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 4, characterized in that: In step (1), the ratio of Platycladus orientalis leaves, dried ginger and Eclipta prostrata is 2:1:1, the solid-liquid ratio is 1:10, the ethanol concentration is 70%, the ultrasonic extraction power is 400 W, the extraction time is 1 h, and the operation is repeated once.
6. A method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 4, characterized in that: The temperature of the rotary evaporation in step (3) is 60-70° C., the extraction time is 20 min, and the operation is repeated 3 times.
7. A method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 4, characterized in that: The rotary evaporation temperature in step (4) is 35-45°C.
8. The method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 3, characterized in that: The temperature of the oil phase water bath heating is 80°C.
9. The method for preparing a compound Platycladus orientalis leaf ointment for improving hair loss according to claim 3, characterized in that: The temperature of the water phase water bath heating is 80°C.
10. The method for preparing a compound Platycladus orientalis leaf cream for improving hair loss according to claim 3, characterized in that: The rotation speed of the magnetic stirrer is 1000 rpm, and the stirring time is 30 min.