Preparation method of gingiva protecting composition

Abstract

The invention relates to the technical field of oral care treatment, in particular to a preparation method of a gingival protecting composition, and the gingival protecting composition comprises the following raw materials: a saffron crocus extract, ganoderma lucidum spore oil and a ginger extract; the preparation method comprises the steps of obtaining preparation raw materials; respectively extracting to obtain a saffron crocus extract, ganoderma lucidum spore oil and a ginger extract; obtaining the content corresponding to a plurality of characteristic components in each raw material, and determining a key ratio according to the content of each characteristic component; the preparation method comprises the following steps: stirring and mixing the saffron crocus extract, the ganoderma lucidum spore oil and the ginger extract according to a key ratio to obtain a premixed gingiva protecting composition, and standing; determining an emulsion stability characterization value of the gingival protecting composition; and adjusting ultrasonic emulsification stirring parameters based on the emulsification stability characterization value and a preset target stable duration to obtain the emulsified liquid of the homogenized gingival protecting composition. The preparation efficiency of the gingival protecting composition can be improved, and the gingival protecting capability is improved.

Description

Technical Field

[0001] The invention relates to the technical field of oral care, and in particular to a preparation method of a gum protection composition. Background Art

[0002] Periodontitis (periodontal disease, gum disease) is a chronic inflammatory disease and progressive destruction of the bone that attaches to the teeth, primarily due to dental plaque and its bacteria. Approximately 90% of people worldwide suffer from gingivitis, a superficial inflammation with bleeding gums, which, if left uncontrolled, may progress to periodontitis, a deep-rooted inflammation of the gums that destroys the bone that holds the teeth in place. This chronic disease causes gum recession in more than 30% of adults, which has a significant impact on aging, nutrition, self-confidence, smiles, and the severity of several other conditions.

[0003] Chinese patent publication number CN114053332 discloses a gum-protecting and antibacterial composition, a tooth-healthy and gum-protecting toothpaste, an application and a preparation method. The gum-protecting and antibacterial composition comprises the following ingredients in parts by weight: 0.05 to 0.3 parts of a Forsythia suspensa extract, 0.05 to 0.3 parts of a honeysuckle extract, 0.02 to 0.1 parts of a Rhodiola rosea extract and 1 to 3 parts of sodium lauroyl sarcosinate. The preparation method of the Rhodiola rosea extract comprises the following steps: crushing the Rhodiola rosea, adding water equivalent to 6 to 8 times the mass of the Rhodiola rosea, performing microwave extraction for 10 to 15 minutes at a power of 1500 to 1600 W and a temperature of 40 to 50° C., then adding cellulase equivalent to 1.5 to 2.5% of the mass of the Rhodiola rosea, performing enzymolysis at 40 to 50° C. for 2 to 3 hours, heating to 90 to 95° C. and maintaining for 5 to 10 minutes to inactivate the enzyme, filtering to obtain an enzymolysis solution and a filter residue; adding a 35 to 55% v / v ethanol aqueous solution equivalent to 4 to 6 times the mass of the filter residue to the filter residue, performing ultrasonic extraction for 20 to 30 minutes at a frequency of 50 to 70 kHz, and then performing ultrasonic extraction for 20 to 30 minutes at a frequency of 20 to 30 kHz, filtering to obtain an ultrasonic extract; combining the enzymolysis solution and the ultrasonic extract, and concentrating to 1.2 to 1.3 g / ml to obtain the Rhodiola rosea extract.

[0004] It can be seen that the above invention has the following problems: the preparation process is relatively complicated, resulting in a relatively low preparation efficiency of the gum protection composition. Summary of the invention

[0005] To this end, the present invention provides a method for preparing a gum protection composition, so as to overcome the problem of relatively low preparation efficiency of the gum protection composition in the prior art.

[0006] To achieve the above object, the present invention provides a method for preparing a gum protection composition, comprising:

[0007] The raw materials of the gum protection composition include saffron extract, ganoderma lucidum spore oil and ginger extract;

[0008] The preparation method of the gum protection composition comprises:

[0009] Step S1, obtaining raw materials for preparation; the raw materials for preparation include saffron, ganoderma lucidum spore powder and ginger;

[0010] Step S2, extracting saffron, ganoderma lucidum spore powder and ginger respectively to obtain the saffron extract, the ganoderma lucidum spore oil and the ginger extract;

[0011] Step S3, obtaining the corresponding contents of several characteristic components in each raw material, and determining the key ratio according to the contents of each characteristic component;

[0012] Step S4, stirring and mixing the saffron extract, the ganoderma lucidum spore oil and the ginger extract according to the key ratio to obtain a premixed gum protection composition, and letting it stand;

[0013] Step S5, obtaining a layered image of the gum protection composition after standing, and determining an emulsion stability characterization value of the gum protection composition;

[0014] Step S6, adjusting ultrasonic emulsification stirring parameters based on the emulsion stability characterization value and the preset target stability time to obtain a homogenized emulsion of the gum protection composition.

[0015] Furthermore, in step S2, the step of extracting the saffron extract comprises:

[0016] Step S21, pre-treating the screened saffron, and crushing and grinding the pre-treated saffron into powder;

[0017] Step S22, mixing saffron powder and a water-based extractant in a first ratio to obtain a first liquid;

[0018] Step S23, ultrasonically extracting the first liquid at a preset temperature, and separating the residue after the ultrasonic extraction to obtain a saffron extract.

[0019] Furthermore, the step S22 includes:

[0020] Step S221, obtaining the average particle size of the saffron powder to obtain a first particle size;

[0021] Step S222, comparing the first particle size with a first preset particle size threshold, and determining the first ratio according to the comparison result;

[0022] Step S223, mixing the saffron powder and the water-based extractant according to the first ratio to obtain a first liquid.

[0023] Furthermore, the step S23 includes:

[0024] Step S231, determining the extraction time and ultrasonic frequency of ultrasonic extraction according to the first ratio;

[0025] Step S232, performing ultrasonic extraction on the first liquid at a preset temperature according to the determined ultrasonic extraction time and ultrasonic frequency;

[0026] Step S233, separating the residue after ultrasonic extraction to obtain saffron extract.

[0027] Furthermore, in the step S5, the emulsion stability characterization value is determined based on the grayscale difference between the layers of the layered image.

[0028] Furthermore, in step S6, adjusting the ultrasonic emulsification stirring parameters based on the emulsification stability characterization value and the preset target stability time includes:

[0029] Step S61, comparing the emulsion stability characterization value with a preset stability characterization value to determine a first comparison value;

[0030] Step S62, determining a first target stable duration according to the first comparison value and a preset stable duration comparison table;

[0031] Step S63, comparing the first target stable time with the preset target stable time, and determining the adjustment amount of each ultrasonic emulsification stirring parameter according to the comparison result; the ultrasonic emulsification stirring parameters include stirring time and ultrasonic frequency.

[0032] Furthermore, in step S2, the step of extracting the Ganoderma lucidum spore oil comprises:

[0033] Step S24, performing a wall-breaking pretreatment on the Ganoderma lucidum spore powder;

[0034] Step S25, putting the ganoderma lucidum spore powder after the cell wall breaking pretreatment into an extraction reactor for extraction to obtain the ganoderma lucidum spore oil.

[0035] Furthermore, in the step S24, the cell wall breaking pretreatment includes:

[0036] Step S241, vacuum drying the Ganoderma lucidum spore powder;

[0037] Step S242, embrittle the vacuum-dried Ganoderma lucidum spore powder;

[0038] Step S243, breaking the embrittled Ganoderma lucidum spore powder according to a preset breaking method.

[0039] Furthermore, the step S25 includes:

[0040] Step S251, obtaining an average particle size of the Ganoderma lucidum spore powder after the wall-breaking pretreatment to obtain a second particle size;

[0041] Step S252, placing the Ganoderma lucidum spore powder after cell wall breaking pretreatment into the extraction reactor;

[0042] Step S253, introducing supercritical CO2 fluid into the extraction reactor, and adjusting the pressure and temperature in the extraction reactor according to the second particle size to perform extraction;

[0043] Step S254, passing the third liquid obtained by extraction into a separation kettle for separation to obtain Ganoderma lucidum spore oil.

[0044] Furthermore, in step S3, determining the key ratio according to the content of each characteristic component includes:

[0045] If the total content of each of the characteristic components is equal to the corresponding characteristic component content threshold, then determining the key ratio to be the first preset ratio;

[0046] If the total content of each characteristic component is greater than the corresponding characteristic component content threshold, the content of the preset characteristic component in the saffron extract is compared with the preset content threshold; if the content of the preset characteristic component is greater than or equal to the preset content threshold, the content of the ginger extract in the first preset ratio is increased to obtain a second preset ratio; if the content of the preset characteristic component is less than the preset content threshold, the content of the saffron extract in the first preset ratio is increased to obtain a third preset ratio.

[0047] Compared with the prior art, the beneficial effect of the present invention is that the present invention can improve the extraction efficiency and yield of each raw material by extracting saffron, ganoderma lucidum spore powder and ginger to obtain saffron extract, ganoderma lucidum spore oil and ginger extract. By obtaining the content of the characteristic components of each raw material to determine the key ratio, the gum protection ability and preparation efficiency of the gum protection composition can be improved. By determining the emulsification stability characterization value according to the layered image after the pre-mixed gum protection composition is allowed to stand, and adjusting the ultrasonic emulsification stirring parameters in combination with the preset target stable time to stir the pre-mixed gum protection composition again, the stability and gum protection ability of the prepared gum protection composition can be improved.

[0048] Furthermore, the present invention can improve the extraction efficiency of saffron by pretreating the saffron and crushing and grinding it into powder, and can improve the extraction efficiency and yield of saffron by mixing the saffron powder with a water-based extractant in proportion and performing ultrasonic extraction at a preset temperature.

[0049] Furthermore, the present invention can improve the mixing uniformity of saffron powder and water-based extractant by determining the first mixing ratio according to the average particle size of saffron powder and the concentration of water-based extractant, thereby improving the extraction efficiency and yield of saffron.

[0050] Furthermore, the present invention can improve the yield and preparation efficiency of ultrasonic extraction by determining the extraction time and extraction frequency of ultrasonic extraction according to the first ratio and the mass of the first liquid.

[0051] Furthermore, the present invention can improve the accuracy of ultrasonic emulsification stirring and the stability of the gingival protection composition by determining the emulsification stability characterization value according to the grayscale difference between each layer of images, and determining the ultrasonic emulsification stirring parameters based on the emulsification stability characterization value and the preset target stabilization time.

[0052] Furthermore, the present invention can improve the extraction efficiency and yield of Ganoderma lucidum spore oil by pre-treating the Ganoderma lucidum spore powder by breaking the wall.

[0053] Furthermore, the present invention can improve the extraction efficiency and yield by adjusting the pressure and temperature in the extraction reactor according to the average particle size of the Ganoderma lucidum spore powder after the wall-breaking pretreatment and performing extraction through supercritical CO2 fluid. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Figure 1 This is a flow chart of a method for preparing a gum protection composition according to an embodiment of the present invention;

[0055] Figure 2 This is a schematic diagram of the process of extracting the saffron extract according to an embodiment of the present invention;

[0056] Figure 3 Schematic diagram of the process of step S22 of the embodiment of the present invention;

[0057] Figure 4 Schematic diagram of the process of step S23 of the embodiment of the present invention;

[0058] Figure 5 A schematic diagram of a process for adjusting stirring parameters of ultrasonic emulsification according to an embodiment of the present invention;

[0059] Figure 6 The present invention is a schematic diagram of the process of extracting the Ganoderma lucidum spore oil according to an embodiment of the present invention;

[0060] Figure 7This is a schematic diagram of the process of cell wall breaking pretreatment according to an embodiment of the present invention;

[0061] Figure 8 Schematic diagram of the process of step S25 of the embodiment of the present invention. DETAILED DESCRIPTION

[0062] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0063] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0064] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0065] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0066] See also Figure 1 As shown, it is a flow chart of the preparation method of the gum protection composition of the present invention; the present invention provides a preparation method of the gum protection composition, comprising:

[0067] The raw materials of the gum protection composition include saffron extract, ganoderma lucidum spore oil and ginger extract;

[0068] The preparation method of the gum protection composition comprises:

[0069] Step S1, obtaining raw materials for preparation; the raw materials for preparation include saffron, ganoderma lucidum spore powder and ginger;

[0070] Step S2, extracting saffron, ganoderma lucidum spore powder and ginger respectively to obtain the saffron extract, the ganoderma lucidum spore oil and the ginger extract;

[0071] See also Figure 2 As shown, it is a schematic diagram of the process of extracting the saffron extract according to an embodiment of the present invention; specifically, in step S2, the step of extracting the saffron extract includes:

[0072] Step S21, pre-treating the screened saffron, and crushing and grinding the pre-treated saffron into powder;

[0073] In practice, the pretreatment includes selection, washing, drying, etc. Saffron of good quality is selected and washed, and the saffron is placed in a 45°C oven and dried for 10 to 12 hours.

[0074] Step S22, mixing saffron powder and a water-based extractant in a first ratio to obtain a first liquid;

[0075] In practice, the water-based extractant can be any extractant with water as the main component that does not react with saffron powder, such as propylene glycol solution, ethanol solution, etc. Preferably, the mass fraction of the water-based extractant is 40% to 70%.

[0076] See also Figure 3 As shown, it is a schematic diagram of the process of step S22 of an embodiment of the present invention; specifically, step S22 includes:

[0077] Step S221, obtaining the average particle size of the saffron powder to obtain a first particle size;

[0078] It should be noted that those skilled in the art know that any method in the prior art that can calculate the average particle size of saffron powder falls within the scope of protection of the present invention and will not be repeated here. The first particle size in the present invention is the average particle size of saffron powder.

[0079] Step S222, comparing the first particle size with a first preset particle size threshold, and determining the first ratio according to the comparison result;

[0080] In implementation, the first intermediate value is determined based on the ratio of the first particle size to the first preset particle size threshold. If the first particle size is greater than or equal to the first preset particle size threshold, the first ratio is determined based on the product of the first intermediate value and the preset ratio. If the first particle size is less than the first preset particle size threshold, the first ratio is determined based on the product of the square of the first intermediate value and the preset ratio.

[0081] Specifically, the actual implementers can set the first preset particle size threshold according to the actual situation or based on the average of the average particle sizes of saffron powder that have passed the qualification test in historical data. Preferably, the value range of the first preset particle size threshold is set to 30μm to 60μm.

[0082] It is understandable that the actual implementer can set the preset ratio according to the actual situation or based on the mass fraction of the water-based extractant. Preferably, the preset ratio is set in the range of 1 / 4 to 1 / 6.

[0083] For example, if the measured first particle size is 20 μm, the first preset particle size threshold is 50 μm, the preset ratio is 1 / 4, and the first particle size is smaller than the first preset particle size threshold, then (20 / 50) 2 ×(1 / 4)=1 / 25, the first ratio is 1:25, that is, the mass ratio of saffron powder to water-based extractant is 1:25; if the first particle size is measured to be 60μm, the first preset particle size threshold is 50μm, the preset ratio is 1 / 4, and the first particle size is greater than the first preset particle size threshold, then 60 / 50×(1 / 4)=3 / 10, the first ratio is 3:10, that is, the mass ratio of saffron powder to water-based extractant is 3:10.

[0084] Step S223, mixing the saffron powder and the water-based extractant according to the first ratio to obtain a first liquid.

[0085] The present invention can improve the mixing uniformity of saffron powder and water-based extractant by determining the first mixing ratio according to the average particle size of saffron powder and the concentration of water-based extractant, thereby improving the extraction efficiency and yield of saffron.

[0086] Step S23, ultrasonically extracting the first liquid at a preset temperature, and separating the residue after the ultrasonic extraction to obtain a saffron extract.

[0087] In implementation, the actual implementer can set the preset temperature according to the actual situation or the average value of the ultrasonic extraction temperature of the saffron extract that has passed the qualification test in historical data. Preferably, the preset temperature value range is set to 40°C to 60°C.

[0088] See also Figure 4 As shown, it is a flow chart of step S23 of an embodiment of the present invention; specifically, step S23 includes:

[0089] Step S231, determining the extraction time and ultrasonic frequency of ultrasonic extraction according to the first ratio;

[0090] In implementation, if the first ratio is greater than the first preset threshold, the second intermediate value is determined according to the product of the first ratio and the standard extraction time, and the extraction time of ultrasonic extraction is determined according to the sum of the second intermediate value and the standard extraction time, the third intermediate value is determined according to the product of the first ratio and the standard ultrasonic frequency, and the ultrasonic frequency of ultrasonic extraction is determined according to the sum of the third intermediate value and the standard ultrasonic frequency; if the first ratio is less than or equal to the first preset threshold, the extraction time of ultrasonic extraction is determined to be the standard extraction time, and the extraction frequency of ultrasonic extraction is determined to be the standard extraction frequency.

[0091] Specifically, the actual implementers can determine the standard extraction time according to the actual situation or based on the mean extraction time of the ultrasonic extraction corresponding to the saffron extract that has passed the qualification test in the historical data. Preferably, the standard extraction time ranges from 40min to 60min; the actual implementers can determine the standard extraction frequency according to the actual situation or based on the mean extraction frequency of the ultrasonic extraction corresponding to the saffron extract that has passed the qualification test in the historical data. Preferably, the standard extraction frequency ranges from 20Hz to 60Hz.

[0092] The present invention can improve the yield and preparation efficiency of ultrasonic extraction by determining the extraction time and extraction frequency of ultrasonic extraction according to the first ratio, the standard extraction time and the standard extraction frequency.

[0093] Step S232, performing ultrasonic extraction on the first liquid at a preset temperature according to the determined ultrasonic extraction time and ultrasonic frequency;

[0094] Step S233, separating the residue after ultrasonic extraction to obtain saffron extract.

[0095] In practice, the residue after ultrasonic extraction can be separated by filtration.

[0096] The present invention can improve the extraction efficiency of saffron by pretreating saffron and crushing and grinding it into powder, and can improve the extraction efficiency and yield of saffron by mixing saffron powder with a water-based extractant in proportion and performing ultrasonic extraction at a preset temperature.

[0097] See also Figure 6 As shown, it is a schematic diagram of the process of extracting the Ganoderma lucidum spore oil according to an embodiment of the present invention; specifically, in step S2, the step of extracting the Ganoderma lucidum spore oil includes:

[0098] Step S24, performing a wall-breaking pretreatment on the Ganoderma lucidum spore powder;

[0099] See also Figure 7As shown, it is a schematic diagram of the process of cell wall breaking pretreatment in an embodiment of the present invention; specifically, in the step S24, the cell wall breaking pretreatment includes:

[0100] Step S241, vacuum drying the Ganoderma lucidum spore powder;

[0101] It should be noted that those skilled in the art know that any method in the prior art that can vacuum dry the Ganoderma lucidum spore powder falls within the scope of protection of the present invention and will not be described in detail herein. For example: lower the temperature to -50°C to -60°C, start and maintain the vacuum degree at 10Pa to 20Pa for 10 to 12 hours; then raise the temperature to 18°C ​​to 28°C and maintain for 1 to 2 hours to obtain the vacuum dried Ganoderma lucidum spore powder.

[0102] Step S242, embrittle the vacuum-dried Ganoderma lucidum spore powder;

[0103] It should be noted that those skilled in the art know that any method in the prior art that can embrittle the Ganoderma lucidum spore powder falls within the protection scope of the present invention and will not be described in detail herein. For example, the embrittlement conditions are adjusted to a embrittlement temperature of 100° C., a vacuum drying temperature of 80° C., and a vacuum drying time of 1 hour.

[0104] Step S243, breaking the embrittled Ganoderma lucidum spore powder according to a preset breaking method.

[0105] In implementation, the preset wall breaking methods include ultrafine grinding method and ultrasonic wall breaking method.

[0106] The invention can improve the extraction efficiency and yield of ganoderma spore oil by vacuum drying, embrittlement and wall breaking of ganoderma spore powder.

[0107] Step S25, putting the ganoderma lucidum spore powder after the cell wall breaking pretreatment into an extraction reactor for extraction to obtain the ganoderma lucidum spore oil.

[0108] See also Figure 8 As shown, it is a schematic diagram of the process of step S25 of an embodiment of the present invention; specifically, step S25 includes:

[0109] Step S251, obtaining an average particle size of the Ganoderma lucidum spore powder after the wall-breaking pretreatment to obtain a second particle size;

[0110] Step S252, placing the Ganoderma lucidum spore powder after cell wall breaking pretreatment into the extraction reactor;

[0111] Step S253, introducing supercritical CO2 fluid into the extraction reactor, and adjusting the pressure and temperature in the extraction reactor according to the second particle size to perform extraction;

[0112] In implementation, the second particle size is the average particle size of the Ganoderma lucidum spore powder after wall-breaking pretreatment. The fourth intermediate value is determined according to the ratio of the second particle size to the second preset particle size threshold. If the second particle size is greater than the second preset particle size threshold, the extraction pressure in the current extraction reactor is determined according to the product of the fourth intermediate value and the standard extraction pressure, and the extraction temperature in the current extraction reactor is determined according to the product of the fourth intermediate value and the standard extraction temperature. If the second particle size is less than or equal to the second preset particle size threshold, the extraction pressure in the current extraction reactor is determined to be the standard extraction pressure, and the extraction temperature in the current extraction reactor is determined to be the standard extraction temperature.

[0113] Specifically, the actual implementers can set the second preset particle size threshold value according to the actual situation or based on the mean of the average particle size of the Ganoderma lucidum spore powder that has passed the qualification test in the historical data. Preferably, the value range of the second preset particle size threshold value is set to 10μm~30μm; the actual implementers can determine the standard extraction pressure according to the actual situation or based on the mean of the extraction pressure corresponding to the Ganoderma lucidum spore oil that has passed the qualification test in the historical data. Preferably, the value range of the standard extraction pressure is 15MPa~40MPa; the actual implementers can determine the standard extraction temperature according to the actual situation or based on the mean of the extraction temperature corresponding to the Ganoderma lucidum spore oil that has passed the qualification test in the historical data. Preferably, the value range of the standard extraction temperature is 35℃~55℃.

[0114] Step S254, passing the third liquid obtained by extraction into a separation kettle for separation to obtain Ganoderma lucidum spore oil.

[0115] The invention adjusts the pressure and temperature in the extraction reaction kettle according to the average particle size of the ganoderma lucidum spore powder after wall-breaking pretreatment, and extracts through supercritical CO2 fluid, thereby improving the extraction efficiency and yield.

[0116] Step S3, obtaining the corresponding contents of several characteristic components in each raw material, and determining the key ratio according to the contents of each characteristic component;

[0117] In implementation, the characteristic components include polyphenols, amino acids, proteins, vitamins, unsaturated fatty acids, ginger essential oil, terpenoids, etc.; the characteristic components of saffron extract include polyphenols, amino acids, proteins, vitamins, terpenoids, the characteristic components of Ganoderma lucidum spore oil include unsaturated fatty acids and terpenoids; the characteristic components of ginger extract include polyphenols, ginger essential oil, and terpenoids.

[0118] Specifically, in step S3, determining the key ratio according to the content of each characteristic component includes:

[0119] If the total content of each of the characteristic components is equal to the corresponding characteristic component content threshold, then determining the key ratio to be the first preset ratio;

[0120] If the total content of each characteristic component is greater than the corresponding characteristic component content threshold, the content of the preset characteristic component in the saffron extract is compared with the preset content threshold; if the content of the preset characteristic component is greater than or equal to the preset content threshold, the content of the ginger extract in the first preset ratio is increased to obtain a second preset ratio; if the content of the preset characteristic component is less than the preset content threshold, the content of the saffron extract in the first preset ratio is increased to obtain a third preset ratio.

[0121] Specifically, the preset characteristic components are characteristic components common to saffron extract and ginger extract, such as polyphenols.

[0122] It should be noted that the increase in the content of ginger extract and saffron extract in the first preset ratio is determined according to the product of the ratio of the content of the preset characteristic component to the preset content threshold and the original content in the first preset ratio.

[0123] It is understandable that the actual implementer can set the preset content threshold based on the average content of the preset characteristic component in the gum protection composition that has passed the qualification test in the historical data. Preferably, the preset content threshold value range is set to 1 mg / kg to 1.8 mg / kg.

[0124] In implementation, the actual implementers can set the characteristic component content threshold corresponding to each characteristic component according to the actual situation or based on the mean value of each characteristic component in the gum protection composition that has passed the qualification test in historical data. Preferably, the characteristic component content threshold value range corresponding to polyphenols is set to 2mg / kg~2.5mg / kg; the characteristic component content threshold value range corresponding to amino acids is set to 0.5mg / kg~1.5mg / kg; the characteristic component content threshold value range corresponding to proteins is set to 4mg / kg~7mg / kg; the characteristic component content threshold value range corresponding to vitamins is set to 3mg / kg~5mg / kg; the characteristic component content threshold value range corresponding to unsaturated fatty acids is set to 0.5mg / kg~2mg / kg; the characteristic component content threshold value range corresponding to ginger essential oil is set to 0.1mg / kg~1mg / kg; the characteristic component content threshold value range corresponding to terpenoid compounds is set to 1mg / kg~2.5mg / kg.

[0125] It is understandable that the actual implementers can set the first preset ratio, the second preset ratio, and the third preset ratio based on the test results of the gum protection composition that has passed the qualification test in the historical data or according to the actual requirements for each characteristic component in the actual application.

[0126] Step S4, stirring and mixing the saffron extract, the ganoderma lucidum spore oil and the ginger extract according to the key ratio to obtain a premixed gum protection composition, and letting it stand;

[0127] Step S5, obtaining a layered image of the gum protection composition after standing, and determining an emulsion stability characterization value of the gum protection composition;

[0128] Specifically, in the step S5, the emulsion stability characterization value is determined based on the grayscale difference between the layers of the layered image.

[0129] Specifically, the image may be divided into layers based on gray value threshold, edge-based segmentation, region-based segmentation, and other algorithms, which will not be described in detail here.

[0130] It should be noted that those skilled in the art are aware that any method in the prior art that can calculate the grayscale value of the layered image of the gum protection composition falls within the protection scope of the present invention and will not be described in detail herein.

[0131] In implementation, the grayscale differences between the layers of the layered image are calculated, and the emulsion stability characterization value is determined according to the ratio of the maximum grayscale difference to the minimum grayscale difference.

[0132] Step S6, adjusting ultrasonic emulsification stirring parameters based on the emulsion stability characterization value and the preset target stability time to obtain a homogenized emulsion of the gum protection composition.

[0133] It can be understood that the emulsion stability characterization value is calculated from the layered image obtained after a preset standing time. The preset standing time is generally between 30 minutes and 120 minutes. The preset target stability time is generally taken as the maximum transit time from the preparation of the prepared gingival protection composition to the addition to each matrix (toothpaste, mouthwash, gargle, etc.). Depending on the specific application scenario, there may be raw material transit inventory time. The specific preset target stability time is determined according to the production scenario and is not limited here.

[0134] The present invention extracts saffron, ganoderma lucidum spore powder and ginger to obtain saffron extract, ganoderma lucidum spore oil and ginger extract, thereby improving the extraction efficiency and yield of each raw material. By obtaining the content of characteristic components of each raw material to determine the key ratio, the gum protection ability and preparation efficiency of the gum protection composition can be improved. By determining the emulsification stability characterization value according to the layered image of the premixed gum protection composition after standing, and adjusting the ultrasonic emulsification stirring parameters in combination with the preset target stable time to stir the premixed gum protection composition again, the stability and gum protection ability of the prepared gum protection composition can be improved.

[0135] See also Figure 5As shown, it is a schematic diagram of the process of adjusting the ultrasonic emulsification stirring parameters according to an embodiment of the present invention; specifically, in the step S6, the ultrasonic emulsification stirring parameters are adjusted based on the emulsification stability characterization value and the preset target stability time, including:

[0136] Step S61, comparing the emulsion stability characterization value with a preset stability characterization value to determine a first comparison value;

[0137] In implementation, actual implementers can set a preset stability characterization value based on actual conditions or based on the average of the ratios of the maximum grayscale difference to the minimum grayscale difference between the grayscale differences of each layer of the gingival protection composition layered images that have passed the qualification test in historical data. Preferably, the preset stability characterization value is set in the range of 1.5 to 3.

[0138] Specifically, the first comparison value is the ratio of the emulsification stability characterization value to the preset stability characterization value.

[0139] Step S62, determining a first target stable duration according to the first comparison value and a preset stable duration comparison table;

[0140] In implementation, the actual implementers can set a preset stability time comparison table based on the actual situation or based on the emulsification stability characterization values ​​of the gingival protection composition that has passed the qualification test in historical data and its corresponding target stability time. Preferably, the preset stability time comparison table includes the value range of the first comparison value: 0-1 (excluding 0), 1-3 (excluding 1), 3-5 (excluding 3), 5-10 (excluding 5), and the target stability time value range corresponding to each first comparison value range is set to: 200h-180h, 150h-120h, 100h-80h, 60h-40h.

[0141] Step S63, comparing the first target stable time with the preset target stable time, and determining the adjustment amount of each ultrasonic emulsification stirring parameter according to the comparison result; the ultrasonic emulsification stirring parameters include stirring time and ultrasonic frequency.

[0142] In implementation, the fifth intermediate value is determined based on the ratio of the first target stable time and the preset target stable time, the adjustment amount of the ultrasonic emulsification stirring time is determined based on the product of the fifth intermediate value and the standard stirring time, and the adjustment amount of the ultrasonic emulsification ultrasonic frequency is determined based on the product of the fifth intermediate value and the standard ultrasonic frequency.

[0143] Specifically, the actual implementer can set the standard stirring time according to the actual situation or the average stirring time of the ultrasonic emulsification of the gum protection composition that has passed the qualification test in the historical data. Preferably, the value range of the standard stirring time is set to 5h to 10h; the actual implementer can set the standard ultrasonic frequency according to the actual situation or the average ultrasonic frequency of the ultrasonic emulsification of the gum protection composition that has passed the qualification test in the historical data. Preferably, the value range of the standard ultrasonic frequency is set to 30Hz to 50Hz;

[0144] The present invention determines the emulsification stability characterization value according to the grayscale difference between each layer of images, and determines the ultrasonic emulsification stirring parameter based on the emulsification stability characterization value and the preset target stabilization time, thereby improving the accuracy of ultrasonic emulsification stirring and the stability of the gum protection composition.

[0145] Specifically, the raw materials of the gum protection composition also include dipotassium glycyrrhizinate. The actual implementers can determine the addition ratio of dipotassium glycyrrhizinate according to actual needs. Preferably, the content of each component in the gum protection composition can be 0.1 to 5 parts of saffron extract, 0.01 to 2 parts of Ganoderma lucidum spore oil, 0 to 0.8 parts of dipotassium glycyrrhizinate, and 0.001 to 0.3 parts of ginger extract.

[0146] Embodiment 1:

[0147] The present embodiment provides a gum protection composition prepared by the preparation method of the gum protection composition of the present invention, wherein the key ratio is the first preset ratio (the mass ratio of saffron extract, ganoderma lucidum spore oil and ginger extract is 1:0.5:0.01), and the tested gum protection effect and stability are shown in Table 1 below.

[0148] Embodiment 2:

[0149] The present embodiment provides a gum protection composition prepared by the preparation method of the gum protection composition of the present invention, the key ratio is the second preset ratio (the mass ratio of saffron extract, Ganoderma lucidum spore oil and ginger extract is 3:1.5:0.2), and the tested gum protection effect and stability are shown in Table 1 below.

[0150] Embodiment 3:

[0151] The present embodiment provides a gum protection composition prepared by the preparation method of the gum protection composition of the present invention, the key ratio is the third preset ratio (the mass ratio of saffron extract, Ganoderma lucidum spore oil and ginger extract is 2:1.5:0.1), and the tested gum protection effect and stability are shown in Table 1 below.

[0152] Embodiment 4:

[0153] The present embodiment provides a gum protection composition prepared by the preparation method of the gum protection composition of the present invention, wherein the mass ratio of saffron extract, ganoderma lucidum spore oil, dipotassium glycyrrhizinate and ginger extract is 0.2:0.11:0.3:0.0011, and the tested gum protection effect and stability are shown in Table 1 below.

[0154] Table 1 Gum protection effect and stability

[0155]

[0156] Table 1 shows that the gum protection composition prepared by the present invention has good stability, can enhance the healing ability of cells, and has a good gum protection effect.

[0157] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

Claims

1. A method for preparing a gum protection composition, characterized in that: The raw materials of the gum protection composition include saffron extract, ganoderma lucidum spore oil and ginger extract; The preparation method of the gum protection composition comprises: Step S1, obtaining raw materials for preparation; the raw materials for preparation include saffron, ganoderma lucidum spore powder and ginger; Step S2, extracting saffron, ganoderma lucidum spore powder and ginger respectively to obtain the saffron extract, the ganoderma lucidum spore oil and the ginger extract; Step S3, obtaining the corresponding contents of several characteristic components in each raw material, and determining the key ratio according to the contents of each characteristic component; Step S4, stirring and mixing the saffron extract, the ganoderma lucidum spore oil and the ginger extract according to the key ratio to obtain a premixed gum protection composition, and letting it stand; Step S5, obtaining a layered image of the gum protection composition after standing, and determining an emulsion stability characterization value of the gum protection composition; Step S6, adjusting ultrasonic emulsification stirring parameters based on the emulsion stability characterization value and the preset target stability time to obtain a homogenized emulsion of the gum protection composition.

2. The method for preparing the gum protection composition according to claim 1, characterized in that: In step S2, the step of extracting the saffron extract comprises: Step S21, pre-treating the screened saffron, and crushing and grinding the pre-treated saffron into powder; Step S22, mixing saffron powder and a water-based extractant in a first ratio to obtain a first liquid; Step S23, ultrasonically extracting the first liquid at a preset temperature, and separating the residue after the ultrasonic extraction to obtain a saffron extract.

3. The method for preparing the gum protection composition according to claim 2, characterized in that: The step S22 comprises: Step S221, obtaining the average particle size of the saffron powder to obtain a first particle size; Step S222, comparing the first particle size with a first preset particle size threshold, and determining the first ratio according to the comparison result; Step S223, mixing the saffron powder and the water-based extractant according to the first ratio to obtain a first liquid.

4. The method for preparing the gum protection composition according to claim 3, characterized in that: The step S23 comprises: Step S231, determining the extraction time and ultrasonic frequency of ultrasonic extraction according to the first ratio; Step S232, performing ultrasonic extraction on the first liquid at a preset temperature according to the determined ultrasonic extraction time and ultrasonic frequency; Step S233, separating the residue after ultrasonic extraction to obtain saffron extract.

5. The method for preparing the gum protection composition according to claim 4, characterized in that: In the step S5, the emulsion stability characterization value is determined based on the grayscale difference between the layer images of the layered image.

6. The method for preparing the gum protection composition according to claim 5, characterized in that: In the step S6, adjusting the ultrasonic emulsification stirring parameters based on the emulsification stability characterization value and the preset target stability time includes: Step S61, comparing the emulsion stability characterization value with a preset stability characterization value to determine a first comparison value; Step S62, determining a first target stable duration according to the first comparison value and a preset stable duration comparison table; Step S63, comparing the first target stable time with the preset target stable time, and determining the adjustment amount of each ultrasonic emulsification stirring parameter according to the comparison result; the ultrasonic emulsification stirring parameters include stirring time and ultrasonic frequency.

7. The method for preparing the gum protection composition according to claim 6, characterized in that: In step S2, the step of extracting the Ganoderma lucidum spore oil comprises: Step S24, performing a wall-breaking pretreatment on the Ganoderma lucidum spore powder; Step S25, putting the ganoderma lucidum spore powder after the cell wall breaking pretreatment into an extraction reactor for extraction to obtain the ganoderma lucidum spore oil.

8. The method for preparing the gum protection composition according to claim 7, characterized in that: In the step S24, the cell wall breaking pretreatment includes: Step S241, vacuum drying the Ganoderma lucidum spore powder; Step S242, embrittle the vacuum-dried Ganoderma lucidum spore powder; Step S243, breaking the embrittled Ganoderma lucidum spore powder according to a preset breaking method.

9. The method for preparing the gum protection composition according to claim 8, characterized in that: The step S25 comprises: Step S251, obtaining an average particle size of the Ganoderma lucidum spore powder after the wall-breaking pretreatment to obtain a second particle size; Step S252, placing the Ganoderma lucidum spore powder after cell wall breaking pretreatment into the extraction reactor; Step S253, introducing supercritical CO2 fluid into the extraction reactor, and adjusting the pressure and temperature in the extraction reactor according to the second particle size to perform extraction; Step S254, passing the third liquid obtained by extraction into a separation kettle for separation to obtain Ganoderma lucidum spore oil.

10. The method for preparing the gum protection composition according to claim 9, characterized in that: In step S3, determining the key ratio according to the content of each characteristic component includes: If the total content of each of the characteristic components is equal to the corresponding characteristic component content threshold, the key ratio is determined to be the first preset ratio; If the total content of each characteristic component is greater than the corresponding characteristic component content threshold, the content of the preset characteristic component in the saffron extract is compared with the preset content threshold; if the content of the preset characteristic component is greater than or equal to the preset content threshold, the content of the ginger extract in the first preset ratio is increased to obtain a second preset ratio; if the content of the preset characteristic component is less than the preset content threshold, the content of the saffron extract in the first preset ratio is increased to obtain a third preset ratio.

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