Nitrogen-containing heterocyclic ring synthesis device and method

Abstract

The synthesis device comprises a base, a supporting rod is fixedly connected to the base, a plurality of irradiation lamps are fixedly connected to the supporting rod, and a plurality of box bodies corresponding to the irradiation lamps respectively are fixedly connected to the supporting rod; a fixing assembly and an overturning assembly are arranged between the box body and the supporting rod, the fixing assembly comprises a rotating part arranged on the supporting rod and a fixing plate fixedly connected to the box body, the fixing plate and the rotating part are each provided with two sets of fixing holes, and fixing buckles are inserted into the fixing holes; the fixing assembly comprises a fixing part fixedly connected to the fixing plate, and a fixing groove matched with the fixing part is formed in the rotating part. Compared with the prior art, the device and the method for synthesizing the nitrogen-containing heterocyclic ring have the advantages that the nitrogen-containing heterocyclic ring aromatic hydrocarbon compound can fully receive illumination, and the illumination is more comprehensive.

Description

Technical Field

[0001] The invention belongs to the technical field of nitrogen-containing heterocyclic compounds, and particularly relates to a synthesis device and method of nitrogen-containing heterocyclic compounds. Background Art

[0002] Nitrogen-containing heterocyclic aromatic compounds are widely used in the fields of medicine, pesticides and materials science. Usually, the arylation of N-heterocyclic aromatics is achieved by the construction of halogenated aromatics, including nucleophilic substitution reactions of electron-deficient halogenated aromatics, transition metal palladium catalysis, amination and copper-catalyzed coupling reactions.

[0003] Existing nitrogen-containing heterocyclic aromatic hydrocarbon compounds need to be irradiated by an irradiation device during the synthesis process. Generally, the nitrogen-containing heterocyclic aromatic hydrocarbon compounds are placed in a box, and an irradiation lamp is set above the box for irradiation. The box is generally high, so the light is not easy to irradiate the bottom of the compound, resulting in the nitrogen-containing heterocyclic aromatic hydrocarbon compounds cannot fully receive light, thereby affecting the reaction effect of synthesizing the nitrogen-containing heterocyclic aromatic hydrocarbon compounds. Summary of the invention

[0004] The object of the present invention is to provide a synthesis device and method for nitrogen-containing heterocycles, which can enable nitrogen-containing heterocyclic aromatic hydrocarbon compounds to fully receive light, and the light exposure is more comprehensive.

[0005] In order to achieve the above purpose, the technical solution provided by a specific embodiment of the present invention is as follows:

[0006] A synthesis device for nitrogen-containing heterocycles comprises a base, to which a support rod is fixedly connected, to which a plurality of irradiation lamps are fixedly connected, to which a plurality of boxes respectively corresponding to the irradiation lamps are fixedly connected, and a fixing component and a flipping component are arranged between the box and the support rod.

[0007] In one or more embodiments of the present invention, the fixing assembly includes a rotating portion disposed on the support rod and a fixing plate fixedly connected to the box body.

[0008] In one or more embodiments of the present invention, two groups of fixing holes are respectively formed on the fixing plate and the rotating part, and fixing buckles are inserted into the fixing holes.

[0009] In one or more embodiments of the present invention, the fixing assembly includes a fixing portion fixedly connected to the fixing plate, and a fixing groove matching the fixing portion is formed in the rotating portion.

[0010] In one or more embodiments of the present invention, the fixing portion is a shaft rod, and the support rod is provided with a rotation groove matching the rotating portion.

[0011] In one or more embodiments of the present invention, a handle is fixedly connected to the box.

[0012] In one or more embodiments of the present invention, the flip assembly includes a first limiting groove opened at the upper end of the box body and a second limiting groove opened at the lower end of the box body.

[0013] In one or more embodiments of the present invention, the flip assembly includes a first limiting plate and a second limiting plate.

[0014] In one or more embodiments of the present invention, the turnover assembly includes a sealing plate, a plurality of pins are provided on the box body, and a baffle is provided on the pins.

[0015] A method for synthesizing a nitrogen-containing heterocycle comprises the following steps:

[0016] (1) Laying nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box;

[0017] (2) Turn on the irradiation lamp to irradiate the nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box for the first time;

[0018] (3) Adjust the box to the other side of the support rod through the fixing assembly and the flipping assembly;

[0019] (4) Turning over the box body by means of the fixing assembly and the flipping assembly;

[0020] (5) Adjust the turned box to the bottom of the irradiation lamp for secondary irradiation;

[0021] (6) After irradiation is completed, remove the box.

[0022] Compared with the prior art, the nitrogen-containing heterocyclic synthesis device and method of the present invention can allow nitrogen-containing heterocyclic aromatic hydrocarbon compounds to fully receive light, and the light exposure is more comprehensive. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 This is a schematic structural diagram of a synthesis device for nitrogen-containing heterocycles in one embodiment of the present invention;

[0025] Figure 2 This is a partial structural schematic diagram of a synthesis device for nitrogen-containing heterocycles in one embodiment of the present invention;

[0026] Figure 3A schematic diagram of the side view of a synthesis device of a nitrogen-containing heterocycle in one embodiment of the present invention Figure 1 ;

[0027] Figure 4 A schematic diagram of the side view of a synthesis device of a nitrogen-containing heterocycle in one embodiment of the present invention Figure 2 ;

[0028] Figure 5 A partial cross-sectional view of a synthesis device of a nitrogen-containing heterocycle in one embodiment of the present invention;

[0029] Figure 6 The present invention is a flow chart of a method for synthesizing a nitrogen-containing heterocycle in one embodiment of the present invention.

[0030] Description of main reference numerals:

[0031] 11. Base; 12. Support rod; 13. Illumination lamp; 21. Rotation slot; 22. Rotation part; 31. Box body; 32. Fixing plate; 33. Fixing hole; 34. Fixing buckle; 35. Fixing slot; 36. Fixing part; 41. Handle; 42. First limiting slot; 43. Second limiting slot; 44. Sealing plate; 51. First limiting plate; 52. Second limiting plate; 61. Pin shaft; 62. Baffle. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0033] like Figures 1 to 5 As shown, a synthesis device of nitrogen-containing heterocycles in one embodiment of the present invention includes a base 11, a support rod 12 is fixedly connected to the base 11, a plurality of irradiation lamps 13 are fixedly connected to the support rod 12, a plurality of boxes 31 corresponding to the irradiation lamps 13 are fixedly connected to the support rod 12, and a fixing component and a flipping component are arranged between the box 31 and the support rod 12.

[0034] Specifically, there are three irradiation lamps 13 and three boxes 31. Nitrogen-containing heterocyclic aromatic hydrocarbon compounds are placed in the boxes 31. The nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the boxes 31 can be irradiated by the irradiation lamps 13. The irradiation lamps 13 are prior art, and their specific structure and working principle are not repeated here.

[0035] The nitrogen-containing heterocyclic aromatic compounds in the original higher box are transferred into each box 31, respectively corresponding to the upper, middle and lower parts of the nitrogen-containing heterocyclic aromatic compounds in the original higher box, and can be irradiated at the same time, shortening the irradiation time and making the irradiation more comprehensive.

[0036] The fixing assembly includes a rotating part 22 arranged on the support rod 12 and a fixing plate 32 fixedly connected to the box body 31. Two groups of fixing holes 33 are respectively opened on the fixing plate 32 and the rotating part 22. A fixing buckle 34 is inserted into the fixing hole 33. Both ends of the fixing buckle 34 can be respectively inserted into the fixing hole 33, so as to facilitate the installation and removal of the box body 31.

[0037] The fixing assembly includes a fixing portion 36 fixedly connected to the fixing plate 32 . A fixing groove 35 matching the fixing portion 36 is provided in the rotating portion 22 . The fixing portion 36 can be inserted into the fixing groove 35 to increase the stability between the fixing plate 32 and the rotating portion 22 .

[0038] The fixing part 36 is an axle rod, and a rotating groove 21 matching the rotating part 22 is opened on the support rod 12. The rotating part 22 includes a fixing ring matching the rotating groove 21, that is, the box body 31 can rotate on the support rod 12, so that the box body 31 can be adjusted to the opposite side of the irradiation lamp 13, and the box body 31 can be installed and disassembled.

[0039] A handle 41 is fixedly connected to the box body 31 , and the box body 31 is easily rotated by the handle 41 .

[0040] The flip assembly includes a first limit groove 42 opened at the upper end of the box body 31 and a second limit groove 43 opened at the lower end of the box body 31, and the flip assembly includes a first limit plate 51 and a second limit plate 52. The flip assembly includes a sealing plate 44, and a plurality of pins 61 are provided on the box body 31, and a baffle 62 is provided on the pins 61.

[0041] Specifically, the second limiting plate 52 can be magnetically attracted to the upper and lower end surfaces of the box body 31, and the first limiting plate 51 and the second limiting plate 52 can be respectively inserted into the first limiting groove 42 and the second limiting groove 43, and the bottom of the box body 31 can be sealed by one of the first limiting plate 51 and the second limiting plate 52, and the baffle 62 can abut against the first limiting plate 51 or the second limiting plate 52 to prevent separation. The sealing plate 44 can seal the first limiting groove 42 and the second limiting groove 43 to prevent light leakage.

[0042] Furthermore, after irradiating the nitrogen-containing heterocyclic aromatic compounds in the box 31, the box 31 is rotated to the opposite side of the irradiation lamp 13, and the second limiting plate 52 is inserted into the first limiting groove 42. At this time, the nitrogen-containing heterocyclic aromatic compounds in the box 31 are located between the first limiting plate 51 and the second limiting plate 52. Pull out the fixing buckle 34, rotate the box 31 by the handle 41, turn the box 31 180°, and turn over the nitrogen-containing heterocyclic aromatic compounds in the box 31. After the flipping is completed, reinsert the fixing buckle 34 into the fixing hole 33, pull out the upper first limiting plate 51, and magnetically absorb the first limiting plate 51 on the bottom end surface of the box 31, and readjust the box 31 to the bottom of the irradiation lamp 13, so that both sides of the nitrogen-containing heterocyclic aromatic compounds can be irradiated respectively, shortening the irradiation time and making the irradiation more comprehensive.

[0043] like Figure 6 As shown, a method for synthesizing a nitrogen-containing heterocycle in one embodiment of the present invention comprises the following steps:

[0044] 1. Laying nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box 31;

[0045] 2. Turn on the irradiation lamp 13 to irradiate the nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box 31 for the first time;

[0046] 3. Adjust the box 31 to the other side of the support rod 12 through the fixing assembly and the flipping assembly;

[0047] 4. Turn over the box body 31 by means of the fixing assembly and the turning assembly;

[0048] 5. Adjust the turned box 31 to the bottom of the irradiation lamp 13 for secondary irradiation;

[0049] 6. After the irradiation is completed, the box 31 is removed.

[0050] Compared with the prior art, the nitrogen-containing heterocyclic synthesis device and method of the present invention can allow nitrogen-containing heterocyclic aromatic hydrocarbon compounds to fully receive light, and the light exposure is more comprehensive.

[0051] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0052] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A synthesis device for nitrogen-containing heterocycles, characterized in that: It comprises a base, the base is fixedly connected with a support rod, the support rod is fixedly connected with a plurality of irradiation lamps, the support rod is fixedly connected with a plurality of boxes respectively corresponding to the irradiation lamps, and a fixing component and a flipping component are arranged between the box and the support rod.

2. A synthesis device for nitrogen-containing heterocycles according to claim 1, characterized in that: The fixing assembly comprises a rotating part arranged on the supporting rod and a fixing plate fixedly connected to the box body.

3. A synthesis device for nitrogen-containing heterocycles according to claim 2, characterized in that: Two groups of fixing holes are respectively provided on the fixing plate and the rotating part, and fixing buckles are inserted into the fixing holes.

4. A synthesis device for nitrogen-containing heterocycles according to claim 2, characterized in that: The fixing assembly comprises a fixing part fixedly connected to the fixing plate, and a fixing groove matching with the fixing part is arranged in the rotating part.

5. A synthesis device for nitrogen-containing heterocycles according to claim 4, characterized in that: The fixing part is a shaft rod, and the supporting rod is provided with a rotating groove matching the rotating part.

6. A synthesis device for nitrogen-containing heterocycles according to claim 1, characterized in that: A handle is fixedly connected to the box body.

7. A synthesis device for nitrogen-containing heterocycles according to claim 1, characterized in that: The flip assembly includes a first limiting groove opened at the upper end of the box body and a second limiting groove opened at the lower end of the box body.

8. A synthesis device for nitrogen-containing heterocycles according to claim 7, characterized in that: The flip assembly includes a first limiting plate and a second limiting plate.

9. A synthesis device for nitrogen-containing heterocycles according to claim 1, characterized in that: The turnover assembly comprises a sealing plate, a plurality of pins are arranged on the box body, and a baffle is arranged on the pins.

10. A method for synthesizing a nitrogen-containing heterocycle according to any one of claims 1 to 9, characterized in that: The following steps are involved: (1) Laying nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box; (2) Turn on the irradiation lamp to irradiate the nitrogen-containing heterocyclic aromatic hydrocarbon compounds in the box for the first time; (3) Adjust the box to the other side of the support rod through the fixing assembly and the flipping assembly; (4) Turning over the box body by means of the fixing assembly and the flipping assembly; (5) Adjust the turned box to the bottom of the irradiation lamp for secondary irradiation; (6) After irradiation is completed, remove the box.

Images